miRTarBase - #MIRT686937


—
pre-miRNA Information
pre-miRNA hsa-mir-4280   
Genomic Coordinates chr5: 87114879 - 87114954
Description Homo sapiens miR-4280 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4280
Sequence 11| GAGUGUAGUUCUGAGCAGAGC |31
Evidence Experimental
Experiments SOLiD
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1267452683 6 dbSNP
rs921418201 13 dbSNP
rs975577876 15 dbSNP
rs562687273 20 dbSNP
rs968639930 21 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol SFT2D3   
Synonyms -
Description SFT2 domain containing 3
Transcript NM_032740   
Expression
Putative miRNA Targets on SFT2D3
3'UTR of SFT2D3
(miRNA target sites are highlighted)		 
>SFT2D3|NM_032740|3'UTR
   1 GGACCTCGCGCCCTCGCCGCTGGGGAAGTACGCGGAGCCAGCGCCGTCGGAGACCGCGCCGGCCGAGCTGAGGACTGCAC
  81 GCCGCTGTGCGGAAGCCCGTGGCGAAGGCCCTGCCCTAACAGCCTGCGAGTCTAATCCGGGAGCGGCTGCTGCCAGCGGA
 161 GGCGACAGCAGCGTTGGGAGCTCCTCGATGTCAGCTTTTTGTGCTGGACTTGGCACACGCTCTGAAAACTGAGATTTTGT
 241 CATTGAACTGGTGACAGGATGTGAGACGGTTATTAGAAGTTGCTTTCGAAGTAACTGTGGTCTTAGGTTCGGCTGAGTAA
 321 AGAAAAAGGATTTTTCTTCGAGTTAGCTGCTCTTGTGATTTTTCTCAGGCTGTTTTGTCATTTTAAAATCCAGTGGTAGA
 401 TGTAGCTTAGCGACGGTAGTTTTTTGTTTTGGCTATACTAAGACTTGGAAATTATTCTCTCCAGTGTCAGCGAATCCAGA
 481 AGGGTATCAGATTAAACACCGAATTCAGCCACTGGACTTTTAAAAGTACTTAAGATGGTTTATCTCGGGTTTTTTCTTCA
 561 GTTAACAAAATCATAAATATGGTGCCTTATAACATGAAAGGAAAATTAGTTGTGTATTTCACGACGAAAGCGACGGACCA
 641 AAAGAAATTTCCTGCCCCAAGAAGCATGGGATCCAGGAAGGGGCGCGTAGATGCTTAACGGTCTCTTCGGAAATCCTGCA
 721 AATAGAAAGATAATTCTAGATCCGGAATACCTGTATCTGGTGGAAACCATGGATTTCTACAAGCTCGAATTATTCCTCAT
 801 TGTATAGCCTGCTTTGTAAACTAGTTTACAATTTGCAGGCTGATCTTAAGATTTTTTTATATCTAATTGCTGCTGCCTTC
 881 ATTTTAGGTTCAGCAGTTACTTTTAACTACCTTAATTTATTGCCAGAAGGTATGAGCCTAACATTCTGATGAGTCCAGAA
 961 AACTACGTTTTGTCAGTAGCAATACACTAGGAAGTAAAATATATTTAGAATTTAAACATTGTGTGCCAGTGGTCCTCGCG
1041 CTTGACTGCACATCAGTTACTTGAAGAGCCACACCTCAGATCAATGCAGTCAGAACCTGGGAAGTAGGTCCCAGACATCA
1121 GGACCTTTTTAAAGCTCCCCAAGTGATTCTACGTTCCCCAAGTTTGAGGACCACTTTTCTGTGCATTGGCTTGCACAATT
1201 TGAAAATAATGCTTTTCCTGAGCTGGATCCCAGTGTTGCCTTAACAGGGTGTCTGTCGTGCCGCAGTAGAGCACTGCTGC
1281 TTCCTCCAACCCCAAAATTTATGTTCCTAAGTAAGTCAGGTCCCTAAGCCCCGTCCCAAGAAGTGACACAAGTGGCCAAC
1361 ATCCACACTGTAGGCTTGCAGGCTACCCGCCCTGAGATTTGGTAAAGAACACTGCCTTGTTCCCCATCAGTAAACAAGGT
1441 TACCTACCTCAGGAGGCTGCTTGTGAGAGAGCAAATGCAGTATCTTCAGAATGATTTATTTTTTTAATTAATTGTAAAGA
1521 CTTGTGCCATTGGCTGCTCTTTCTAGTCCCCTAAATTTCTGTTCTAGTTTTAAATTTCTCTAGAACTTGCAATAGTTGGG
1601 GGTTTTATAATGATGTTTTACAATGTTTATTTCTTAAATAAAAACTTAAAAATTCAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' cgAGACGAGUCUUGAUGUGAg 5'
            |:||:|: | :|||:||| 
Target 5' ttTTTGTTTTG-GCTATACTa 3'
 421 - 440 142.00 -12.40
2 
miRNA  3' cgagaCGAGUCUUGAUGUGag 5'
               ||| ||:|||:|||  
Target 5' gccgaGCTGAGGACTGCACgc 3'
 62 - 82 132.00 -19.10
3 
miRNA  3' cgAGACGA-----GUC--UUGAUGUGAg 5'
            |||| |     |||  ||||||::| 
Target 5' atTCTGATGAGTCCAGAAAACTACGTTt 3'
 943 - 970 129.00 -14.20
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN28193564 87 COSMIC
COSN30177219 117 COSMIC
COSN28192302 149 COSMIC
COSN30172230 160 COSMIC
COSN31555252 199 COSMIC
COSN31584359 207 COSMIC
COSN30129393 323 COSMIC
COSN31486021 351 COSMIC
COSN31539941 413 COSMIC
COSN30113746 502 COSMIC
COSN28015611 557 COSMIC
COSN31566040 631 COSMIC
COSN31519507 645 COSMIC
COSN27148463 701 COSMIC
COSN31597181 756 COSMIC
COSN31480176 843 COSMIC
COSN30122387 859 COSMIC
COSN31546925 890 COSMIC
COSN31562987 923 COSMIC
COSN30172246 927 COSMIC
COSN30135313 999 COSMIC
COSN31961711 1108 COSMIC
COSN30110645 1155 COSMIC
COSN9079433 1213 COSMIC
COSN15626263 1241 COSMIC
COSN30526858 1261 COSMIC
COSN22314687 1263 COSMIC
COSN31539246 1264 COSMIC
COSN14929628 1333 COSMIC
COSN31481507 1389 COSMIC
COSN31584356 1397 COSMIC
COSN30526915 1492 COSMIC
COSN30511714 1494 COSMIC
COSN30177171 1544 COSMIC
COSN26637290 1547 COSMIC
COSN30113021 1555 COSMIC
COSN4909703 1697 COSMIC
COSN26505518 1754 COSMIC
COSN6676893 1807 COSMIC
COSN24041257 1903 COSMIC
COSN26640217 1965 COSMIC
COSN15626264 1972 COSMIC
COSN5781122 2081 COSMIC
COSN30172598 2110 COSMIC
COSN25434741 2150 COSMIC
COSN30136497 2221 COSMIC
COSN29232426 2239 COSMIC
COSN31555589 2251 COSMIC
COSN31584348 2254 COSMIC
COSN30128601 2265 COSMIC
COSN31551024 2281 COSMIC
COSN30139742 2346 COSMIC
COSN30172534 2399 COSMIC
COSN26586805 2413 COSMIC
COSN29610159 2452 COSMIC
COSN30530851 2467 COSMIC
COSN30531978 2521 COSMIC
COSN30529760 2611 COSMIC
COSN31518513 2645 COSMIC
COSN31554872 2665 COSMIC
COSN24902841 2799 COSMIC
COSN22509344 2828 COSMIC
COSN7336066 2837 COSMIC
COSN6207956 2877 COSMIC
COSN17220190 3054 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs925447844 5 dbSNP
rs1267716677 7 dbSNP
rs1457159854 7 dbSNP
rs993333326 8 dbSNP
rs958468327 12 dbSNP
rs1424377928 13 dbSNP
rs748604528 16 dbSNP
rs1170815266 17 dbSNP
rs1195437042 18 dbSNP
rs770152287 19 dbSNP
rs770599033 20 dbSNP
rs887512005 30 dbSNP
rs760219913 34 dbSNP
rs1205978223 35 dbSNP
rs926524590 36 dbSNP
rs1276587745 41 dbSNP
rs1221490950 42 dbSNP
rs1415954007 43 dbSNP
rs937972561 45 dbSNP
rs537438338 50 dbSNP
rs548233828 57 dbSNP
rs1004461760 62 dbSNP
rs568143475 65 dbSNP
rs1036440379 66 dbSNP
rs530734616 71 dbSNP
rs1331594300 77 dbSNP
rs755620471 80 dbSNP
rs553575474 81 dbSNP
rs1376496184 82 dbSNP
rs1158180907 83 dbSNP
rs1471457294 84 dbSNP
rs988307884 88 dbSNP
rs913991344 91 dbSNP
rs1235857814 93 dbSNP
rs946773251 93 dbSNP
rs979407987 96 dbSNP
rs997497478 97 dbSNP
rs1030363901 99 dbSNP
rs953515558 104 dbSNP
rs1007788645 109 dbSNP
rs1033010553 110 dbSNP
rs958200349 111 dbSNP
rs1377947708 113 dbSNP
rs988304546 114 dbSNP
rs1449517716 117 dbSNP
rs1359690053 119 dbSNP
rs1319736113 122 dbSNP
rs1389569552 124 dbSNP
rs1437022733 125 dbSNP
rs913651320 127 dbSNP
rs1390639118 132 dbSNP
rs753373953 136 dbSNP
rs1423503301 139 dbSNP
rs1411847631 145 dbSNP
rs13405026 153 dbSNP
rs539278146 156 dbSNP
rs1473128269 159 dbSNP
rs778455046 160 dbSNP
rs926281584 164 dbSNP
rs1187288798 165 dbSNP
rs1466620541 170 dbSNP
rs887535523 175 dbSNP
rs1005936454 176 dbSNP
rs758993845 177 dbSNP
rs558979569 184 dbSNP
rs1276492329 187 dbSNP
rs1287237105 188 dbSNP
rs1229546499 192 dbSNP
rs1379352602 203 dbSNP
rs1296213011 209 dbSNP
rs1048272931 217 dbSNP
rs1367234108 220 dbSNP
rs13431323 221 dbSNP
rs1457176836 222 dbSNP
rs1348363098 223 dbSNP
rs1167255055 226 dbSNP
rs1166759018 230 dbSNP
rs1268388797 230 dbSNP
rs1389682551 230 dbSNP
rs1451911159 235 dbSNP
rs1249132983 244 dbSNP
rs1190991765 255 dbSNP
rs1035702319 256 dbSNP
rs139261767 260 dbSNP
rs1223393342 262 dbSNP
rs1036888488 269 dbSNP
rs1273339454 271 dbSNP
rs1451583730 272 dbSNP
rs1200224970 273 dbSNP
rs1298174821 276 dbSNP
rs1386137254 279 dbSNP
rs1365299260 284 dbSNP
rs554578460 292 dbSNP
rs774065199 296 dbSNP
rs574560397 297 dbSNP
rs897897723 298 dbSNP
rs997571126 312 dbSNP
rs1431638993 314 dbSNP
rs540351895 317 dbSNP
rs910623863 318 dbSNP
rs1051868734 323 dbSNP
rs964706178 325 dbSNP
rs1427762271 338 dbSNP
rs1192108875 339 dbSNP
rs1458991056 350 dbSNP
rs1291621682 358 dbSNP
rs976086823 365 dbSNP
rs889085770 383 dbSNP
rs1007982715 388 dbSNP
rs1032590403 389 dbSNP
rs1232505022 391 dbSNP
rs866094735 392 dbSNP
rs958572046 394 dbSNP
rs1417135571 396 dbSNP
rs1325454430 397 dbSNP
rs376261004 406 dbSNP
rs1021109272 408 dbSNP
rs970884352 409 dbSNP
rs1408755026 410 dbSNP
rs532218252 411 dbSNP
rs1302317206 415 dbSNP
rs1048025682 420 dbSNP
rs1033854218 425 dbSNP
rs1177275795 430 dbSNP
rs1472436670 431 dbSNP
rs1242129372 436 dbSNP
rs959061446 439 dbSNP
rs765172495 445 dbSNP
rs905590025 446 dbSNP
rs909780119 452 dbSNP
rs1482246451 455 dbSNP
rs1257627349 460 dbSNP
rs1204060783 469 dbSNP
rs1328303156 489 dbSNP
rs547945821 489 dbSNP
rs939946049 492 dbSNP
rs1482351640 494 dbSNP
rs752509757 496 dbSNP
rs759339312 498 dbSNP
rs972656846 505 dbSNP
rs1405003571 514 dbSNP
rs1252601226 524 dbSNP
rs1303871501 545 dbSNP
rs1457163615 547 dbSNP
rs1473586959 548 dbSNP
rs546024315 549 dbSNP
rs558726637 556 dbSNP
rs562617396 559 dbSNP
rs933816608 560 dbSNP
rs1458235338 564 dbSNP
rs1186237151 567 dbSNP
rs896738218 573 dbSNP
rs531664739 581 dbSNP
rs1051825220 586 dbSNP
rs542900117 587 dbSNP
rs889235661 590 dbSNP
rs1428997024 595 dbSNP
rs1266062276 601 dbSNP
rs1210321414 605 dbSNP
rs1351700735 606 dbSNP
rs1308159804 617 dbSNP
rs1351817713 619 dbSNP
rs943384158 620 dbSNP
rs1315792232 621 dbSNP
rs548171166 622 dbSNP
rs1435060526 623 dbSNP
rs1054221179 624 dbSNP
rs767357597 626 dbSNP
rs1311576025 631 dbSNP
rs1340642890 633 dbSNP
rs1385222943 635 dbSNP
rs568084794 639 dbSNP
rs745329228 642 dbSNP
rs527334471 645 dbSNP
rs1340728748 646 dbSNP
rs968220881 653 dbSNP
rs1369748908 658 dbSNP
rs1163636861 659 dbSNP
rs1448828313 663 dbSNP
rs1000970695 667 dbSNP
rs1447298228 669 dbSNP
rs1017661337 670 dbSNP
rs1021181587 673 dbSNP
rs1208336373 674 dbSNP
rs547523956 685 dbSNP
rs763776141 695 dbSNP
rs570566267 699 dbSNP
rs1255813583 700 dbSNP
rs1424613760 701 dbSNP
rs1185241101 706 dbSNP
rs1228783560 709 dbSNP
rs1330942279 710 dbSNP
rs1321966593 719 dbSNP
rs1388061979 720 dbSNP
rs923259431 723 dbSNP
rs556160182 724 dbSNP
rs1169172295 726 dbSNP
rs13394108 727 dbSNP
rs983788706 728 dbSNP
rs751848845 737 dbSNP
rs1388255163 739 dbSNP
rs1170486169 743 dbSNP
rs79885549 744 dbSNP
rs1376896644 745 dbSNP
rs1196430360 751 dbSNP
rs1453561528 754 dbSNP
rs1269798028 756 dbSNP
rs781515873 758 dbSNP
rs1482151417 774 dbSNP
rs569433989 780 dbSNP
rs780121815 785 dbSNP
rs922523151 788 dbSNP
rs933806708 790 dbSNP
rs941863442 796 dbSNP
rs1235825402 797 dbSNP
rs1347022579 802 dbSNP
rs985739448 805 dbSNP
rs1294885394 818 dbSNP
rs927040744 822 dbSNP
rs1330274314 824 dbSNP
rs1363507064 829 dbSNP
rs370070374 832 dbSNP
rs760707882 835 dbSNP
rs1429726667 846 dbSNP
rs891499744 847 dbSNP
rs1010309651 851 dbSNP
rs1254126358 851 dbSNP
rs1208196473 852 dbSNP
rs1255460620 859 dbSNP
rs1277057564 863 dbSNP
rs1202549329 868 dbSNP
rs1324803156 874 dbSNP
rs1267879429 882 dbSNP
rs1483731175 885 dbSNP
rs1205829320 888 dbSNP
rs1348194798 893 dbSNP
rs865925972 900 dbSNP
rs1280805115 901 dbSNP
rs1053889601 904 dbSNP
rs1246374475 909 dbSNP
rs1448644793 912 dbSNP
rs893786066 914 dbSNP
rs945385986 918 dbSNP
rs554519039 920 dbSNP
rs1042610284 930 dbSNP
rs1158101210 934 dbSNP
rs1455873203 935 dbSNP
rs1188899592 937 dbSNP
rs1410382639 938 dbSNP
rs1177872444 941 dbSNP
rs1472470577 947 dbSNP
rs184208687 950 dbSNP
rs756199455 954 dbSNP
rs1003647794 955 dbSNP
rs1055727750 956 dbSNP
rs780776037 957 dbSNP
rs1267926434 962 dbSNP
rs1431363506 964 dbSNP
rs1001003241 968 dbSNP
rs1285834769 975 dbSNP
rs1005688538 995 dbSNP
rs1223984998 1001 dbSNP
rs1355104227 1002 dbSNP
rs1016684544 1003 dbSNP
rs373548780 1013 dbSNP
rs1470648755 1027 dbSNP
rs960999830 1032 dbSNP
rs1281899092 1038 dbSNP
rs187518193 1039 dbSNP
rs1387382233 1040 dbSNP
rs1216401097 1041 dbSNP
rs1383389291 1042 dbSNP
rs1319672440 1048 dbSNP
rs1432565448 1049 dbSNP
rs540291918 1054 dbSNP
rs1160194283 1055 dbSNP
rs1404974502 1058 dbSNP
rs1411783638 1061 dbSNP
rs993870061 1075 dbSNP
rs1445789473 1081 dbSNP
rs1321641963 1085 dbSNP
rs1187072606 1087 dbSNP
rs1029584471 1090 dbSNP
rs955301228 1098 dbSNP
rs1243037373 1100 dbSNP
rs115991695 1101 dbSNP
rs911018415 1102 dbSNP
rs957246706 1108 dbSNP
rs1287167721 1109 dbSNP
rs143249179 1117 dbSNP
rs191676235 1119 dbSNP
rs1296700604 1125 dbSNP
rs1226078583 1128 dbSNP
rs147504822 1135 dbSNP
rs1289208623 1136 dbSNP
rs1436080491 1137 dbSNP
rs1042393146 1142 dbSNP
rs1305044949 1145 dbSNP
rs1425304057 1150 dbSNP
rs950779283 1153 dbSNP
rs1167321792 1154 dbSNP
rs1225353415 1165 dbSNP
rs1266483100 1170 dbSNP
rs1190932719 1175 dbSNP
rs1420714676 1175 dbSNP
rs928203850 1175 dbSNP
rs983430089 1181 dbSNP
rs939569257 1182 dbSNP
rs769110913 1183 dbSNP
rs1266258560 1184 dbSNP
rs1224081494 1186 dbSNP
rs1016205256 1187 dbSNP
rs895264362 1199 dbSNP
rs1202997792 1201 dbSNP
rs800859 1207 dbSNP
rs1487492331 1209 dbSNP
rs1218365136 1210 dbSNP
rs1190579720 1213 dbSNP
rs1267892886 1224 dbSNP
rs1038119225 1225 dbSNP
rs748501290 1227 dbSNP
rs938510582 1236 dbSNP
rs992626151 1246 dbSNP
rs1464005367 1247 dbSNP
rs1355571903 1248 dbSNP
rs1410859213 1250 dbSNP
rs770588621 1252 dbSNP
rs1029364864 1259 dbSNP
rs1160357055 1262 dbSNP
rs776208515 1263 dbSNP
rs955040352 1264 dbSNP
rs759051142 1284 dbSNP
rs542148397 1288 dbSNP
rs1018195614 1290 dbSNP
rs561626167 1298 dbSNP
rs1481581867 1300 dbSNP
rs1251747354 1303 dbSNP
rs1434709080 1307 dbSNP
rs1209328423 1308 dbSNP
rs1293461044 1308 dbSNP
rs957423481 1314 dbSNP
rs527268102 1323 dbSNP
rs547464003 1326 dbSNP
rs1042674151 1329 dbSNP
rs1393155491 1332 dbSNP
rs563965146 1333 dbSNP
rs570432910 1334 dbSNP
rs1286560589 1340 dbSNP
rs1408827100 1341 dbSNP
rs1177566535 1344 dbSNP
rs1319709184 1350 dbSNP
rs1410710737 1356 dbSNP
rs1220485738 1357 dbSNP
rs1247279638 1360 dbSNP
rs758511562 1364 dbSNP
rs1039260856 1366 dbSNP
rs966793239 1369 dbSNP
rs775553872 1370 dbSNP
rs1244778208 1374 dbSNP
rs1204007051 1379 dbSNP
rs546733945 1383 dbSNP
rs978160405 1386 dbSNP
rs1328767882 1390 dbSNP
rs1472607509 1391 dbSNP
rs561235933 1393 dbSNP
rs939368815 1402 dbSNP
rs1178604843 1404 dbSNP
rs1055749709 1417 dbSNP
rs900704527 1423 dbSNP
rs1312067667 1424 dbSNP
rs1451152610 1425 dbSNP
rs916874424 1427 dbSNP
rs764055191 1430 dbSNP
rs1411089433 1431 dbSNP
rs941523121 1439 dbSNP
rs1164497862 1448 dbSNP
rs751333821 1452 dbSNP
rs1386899850 1453 dbSNP
rs896894840 1455 dbSNP
rs929685514 1456 dbSNP
rs184880795 1464 dbSNP
rs569459223 1465 dbSNP
rs1006567810 1468 dbSNP
rs1018604067 1470 dbSNP
rs1281504377 1480 dbSNP
rs1183976412 1481 dbSNP
rs189387315 1494 dbSNP
rs1227600281 1495 dbSNP
rs1264973080 1496 dbSNP
rs1486301282 1496 dbSNP
rs959928323 1497 dbSNP
rs1362241490 1498 dbSNP
rs17533356 1499 dbSNP
rs1361568011 1504 dbSNP
rs912994013 1505 dbSNP
rs568456979 1506 dbSNP
rs566863623 1511 dbSNP
rs978400611 1513 dbSNP
rs1385163957 1515 dbSNP
rs1292445745 1524 dbSNP
rs1422141999 1530 dbSNP
rs1366891382 1532 dbSNP
rs1164199964 1533 dbSNP
rs1273780882 1534 dbSNP
rs967202159 1546 dbSNP
rs1448772001 1550 dbSNP
rs1371167822 1553 dbSNP
rs925663104 1558 dbSNP
rs942364498 1566 dbSNP
rs1205931357 1568 dbSNP
rs978107906 1568 dbSNP
rs1035074564 1573 dbSNP
rs960985131 1577 dbSNP
rs1205121473 1582 dbSNP
rs551628606 1587 dbSNP
rs900735814 1591 dbSNP
rs1228536172 1600 dbSNP
rs756323871 1601 dbSNP
rs559693321 1607 dbSNP
rs780262565 1616 dbSNP
rs916800159 1625 dbSNP
rs749838604 1630 dbSNP
rs1366953369 1631 dbSNP
rs1181677046 1634 dbSNP
rs1386227258 1635 dbSNP
rs755467804 1639 dbSNP
rs1169443854 1644 dbSNP
rs886531058 1646 dbSNP
rs1446772029 1655 dbSNP
rs1197593378 1668 dbSNP
rs1481521524 1671 dbSNP
rs1004930475 1678 dbSNP
rs1181486872 1679 dbSNP
rs533908252 1680 dbSNP
rs941650269 1681 dbSNP
rs899197713 1682 dbSNP
rs1001522379 1683 dbSNP
rs1370423964 1686 dbSNP
rs1344823135 1692 dbSNP
rs779424048 1704 dbSNP
rs1221349009 1713 dbSNP
rs974337789 1714 dbSNP
rs1034293627 1716 dbSNP
rs13397670 1723 dbSNP
rs577230624 1726 dbSNP
rs1330881390 1727 dbSNP
rs771125191 1730 dbSNP
rs1447549031 1751 dbSNP
rs1173934869 1756 dbSNP
rs1471091182 1763 dbSNP
rs1430177068 1764 dbSNP
rs184551746 1770 dbSNP
rs774440830 1771 dbSNP
rs1384769248 1774 dbSNP
rs7584783 1775 dbSNP
rs978516658 1777 dbSNP
rs890916339 1782 dbSNP
rs1339975376 1783 dbSNP
rs189280554 1785 dbSNP
rs963706039 1790 dbSNP
rs1205922084 1796 dbSNP
rs975463077 1798 dbSNP
rs1197102679 1804 dbSNP
rs7575478 1807 dbSNP
rs933532662 1808 dbSNP
rs1441535883 1818 dbSNP
rs202129381 1822 dbSNP
rs1011424663 1860 dbSNP
rs1020160554 1868 dbSNP
rs1334460368 1871 dbSNP
rs940830594 1872 dbSNP
rs902989724 1874 dbSNP
rs13411917 1878 dbSNP
rs1399154319 1880 dbSNP
rs1410311676 1881 dbSNP
rs1159180181 1882 dbSNP
rs1444586763 1883 dbSNP
rs1035513666 1885 dbSNP
rs13411924 1888 dbSNP
rs1462099852 1889 dbSNP
rs1247769066 1910 dbSNP
rs200130869 1914 dbSNP
rs200765488 1917 dbSNP
rs1214678504 1918 dbSNP
rs1444878809 1924 dbSNP
rs1285770049 1925 dbSNP
rs1223797911 1926 dbSNP
rs1056166932 1933 dbSNP
rs1358647587 1934 dbSNP
rs745505552 1936 dbSNP
rs1023607223 1939 dbSNP
rs1476010576 1945 dbSNP
rs1169779537 1950 dbSNP
rs963053964 1956 dbSNP
rs1014627679 1958 dbSNP
rs1319084902 1961 dbSNP
rs1424028127 1962 dbSNP
rs775954309 1964 dbSNP
rs1363788107 1974 dbSNP
rs541012684 1980 dbSNP
rs13387380 1985 dbSNP
rs1413943833 1988 dbSNP
rs1419284813 1996 dbSNP
rs770352653 2004 dbSNP
rs1474228048 2006 dbSNP
rs763604884 2011 dbSNP
rs918852180 2012 dbSNP
rs1032744291 2017 dbSNP
rs1288929090 2018 dbSNP
rs1408492550 2022 dbSNP
rs1224684459 2023 dbSNP
rs542734990 2026 dbSNP
rs745552255 2028 dbSNP
rs1212531408 2030 dbSNP
rs532860482 2030 dbSNP
rs1364361557 2031 dbSNP
rs1271063472 2032 dbSNP
rs1319636172 2032 dbSNP
rs1343776603 2034 dbSNP
rs1304986811 2040 dbSNP
rs986988369 2043 dbSNP
rs912283846 2045 dbSNP
rs942434469 2047 dbSNP
rs769335264 2049 dbSNP
rs922219934 2050 dbSNP
rs1420651787 2051 dbSNP
rs774895750 2052 dbSNP
rs1479888976 2060 dbSNP
rs762476954 2062 dbSNP
rs1343712812 2076 dbSNP
rs1488774748 2080 dbSNP
rs1250627805 2091 dbSNP
rs1223533130 2097 dbSNP
rs550604709 2099 dbSNP
rs1041607499 2100 dbSNP
rs1326640030 2104 dbSNP
rs908111196 2109 dbSNP
rs1223163355 2111 dbSNP
rs940863057 2115 dbSNP
rs1285283629 2119 dbSNP
rs1247776471 2120 dbSNP
rs1405559314 2120 dbSNP
rs1372694482 2121 dbSNP
rs1447895049 2121 dbSNP
rs1195998928 2125 dbSNP
rs562901356 2125 dbSNP
rs181949103 2126 dbSNP
rs1002644080 2136 dbSNP
rs1444963231 2136 dbSNP
rs1477745365 2145 dbSNP
rs1355519610 2146 dbSNP
rs1056993585 2147 dbSNP
rs1468989684 2156 dbSNP
rs937383875 2158 dbSNP
rs774282551 2171 dbSNP
rs1433337852 2174 dbSNP
rs1249197206 2175 dbSNP
rs770206655 2182 dbSNP
rs1175464547 2185 dbSNP
rs1481559661 2185 dbSNP
rs1238582240 2191 dbSNP
rs1202732083 2199 dbSNP
rs1321673779 2217 dbSNP
rs1012311890 2223 dbSNP
rs895840070 2227 dbSNP
rs1304921684 2230 dbSNP
rs375889084 2231 dbSNP
rs1336504184 2233 dbSNP
rs567524152 2244 dbSNP
rs962671353 2245 dbSNP
rs186051321 2266 dbSNP
rs1338366459 2269 dbSNP
rs1466215620 2273 dbSNP
rs1385429404 2274 dbSNP
rs1383664029 2282 dbSNP
rs568397485 2284 dbSNP
rs867736626 2285 dbSNP
rs534234972 2286 dbSNP
rs1380760880 2287 dbSNP
rs761771083 2291 dbSNP
rs767410907 2305 dbSNP
rs1459857964 2313 dbSNP
rs1244721199 2314 dbSNP
rs777105185 2316 dbSNP
rs1201285775 2322 dbSNP
rs535885636 2322 dbSNP
rs903087798 2327 dbSNP
rs1405099242 2335 dbSNP
rs995542550 2337 dbSNP
rs1025882054 2339 dbSNP
rs1326700357 2346 dbSNP
rs951636298 2358 dbSNP
rs148709568 2359 dbSNP
rs570828202 2364 dbSNP
rs1385501758 2376 dbSNP
rs79003209 2385 dbSNP
rs1396285631 2393 dbSNP
rs997038377 2395 dbSNP
rs190818716 2406 dbSNP
rs143710582 2412 dbSNP
rs535623724 2413 dbSNP
rs1360587725 2414 dbSNP
rs1490327348 2415 dbSNP
rs760946791 2419 dbSNP
rs1271111514 2425 dbSNP
rs1471621810 2433 dbSNP
rs975155500 2437 dbSNP
rs546174820 2442 dbSNP
rs982449691 2442 dbSNP
rs914339884 2443 dbSNP
rs1259836275 2449 dbSNP
rs1207116111 2450 dbSNP
rs1488693420 2451 dbSNP
rs1291106626 2452 dbSNP
rs1364534646 2453 dbSNP
rs748834041 2455 dbSNP
rs1266414697 2462 dbSNP
rs1015203323 2467 dbSNP
rs1325042487 2477 dbSNP
rs555636659 2482 dbSNP
rs1401437506 2484 dbSNP
rs962254485 2486 dbSNP
rs1301947717 2487 dbSNP
rs1389978193 2488 dbSNP
rs947051215 2491 dbSNP
rs973571657 2492 dbSNP
rs920803072 2501 dbSNP
rs766579945 2502 dbSNP
rs774526771 2509 dbSNP
rs1478254887 2512 dbSNP
rs1268313904 2520 dbSNP
rs1348124678 2527 dbSNP
rs1197308746 2533 dbSNP
rs1408622339 2533 dbSNP
rs1490984156 2534 dbSNP
rs1268741515 2535 dbSNP
rs753883232 2538 dbSNP
rs755023128 2551 dbSNP
rs763974438 2570 dbSNP
rs924519125 2571 dbSNP
rs1337143724 2573 dbSNP
rs938573181 2574 dbSNP
rs1332317266 2576 dbSNP
rs1324194303 2577 dbSNP
rs1390730654 2581 dbSNP
rs566261910 2583 dbSNP
rs894273110 2584 dbSNP
rs1172506714 2610 dbSNP
rs572336287 2611 dbSNP
rs1428770742 2619 dbSNP
rs541340918 2620 dbSNP
rs1223909511 2625 dbSNP
rs563881524 2626 dbSNP
rs950114764 2630 dbSNP
rs758819978 2631 dbSNP
rs1060316 2632 dbSNP
rs1436537407 2636 dbSNP
rs1253129999 2639 dbSNP
rs1199601203 2641 dbSNP
rs1457938255 2647 dbSNP
rs1262193334 2651 dbSNP
rs995491925 2652 dbSNP
rs903114118 2653 dbSNP
rs146826165 2654 dbSNP
rs1025620241 2657 dbSNP
rs1274894612 2662 dbSNP
rs1251598756 2664 dbSNP
rs1421073894 2670 dbSNP
rs778086590 2684 dbSNP
rs935878901 2688 dbSNP
rs543094084 2692 dbSNP
rs538345209 2693 dbSNP
rs563396308 2705 dbSNP
rs976025187 2711 dbSNP
rs1165403253 2717 dbSNP
rs1425999044 2721 dbSNP
rs1368572072 2723 dbSNP
rs1428617329 2726 dbSNP
rs181243557 2729 dbSNP
rs1014201723 2741 dbSNP
rs1365990405 2748 dbSNP
rs1179810057 2749 dbSNP
rs1298242690 2749 dbSNP
rs1241662532 2751 dbSNP
rs1278742977 2754 dbSNP
rs1398228724 2754 dbSNP
rs374258272 2754 dbSNP
rs1393905391 2755 dbSNP
rs1311504167 2758 dbSNP
rs968469961 2760 dbSNP
rs1203983226 2762 dbSNP
rs140589041 2763 dbSNP
rs74466242 2764 dbSNP
rs1240753422 2765 dbSNP
rs578115825 2766 dbSNP
rs1312592709 2781 dbSNP
rs13401332 2789 dbSNP
rs1317731474 2804 dbSNP
rs1424569944 2811 dbSNP
rs992727656 2812 dbSNP
rs1362524931 2813 dbSNP
rs1226839474 2823 dbSNP
rs1015229686 2833 dbSNP
rs962368890 2838 dbSNP
rs915849739 2847 dbSNP
rs779700577 2853 dbSNP
rs548079413 2872 dbSNP
rs1183917105 2875 dbSNP
rs1473584904 2876 dbSNP
rs530695764 2884 dbSNP
rs1183264446 2886 dbSNP
rs537603899 2889 dbSNP
rs1444826032 2890 dbSNP
rs1037965314 2891 dbSNP
rs1027897416 2896 dbSNP
rs1481631317 2903 dbSNP
rs1358579928 2908 dbSNP
rs1289338021 2909 dbSNP
rs899010912 2909 dbSNP
rs931359467 2910 dbSNP
rs545991451 2913 dbSNP
rs1269891716 2930 dbSNP
rs1198983189 2945 dbSNP
rs1242693375 2952 dbSNP
rs991650103 2962 dbSNP
rs917337438 2975 dbSNP
rs1185190077 2985 dbSNP
rs1424613435 2990 dbSNP
rs1167361636 2999 dbSNP
rs1364193501 2999 dbSNP
rs1406371075 3005 dbSNP
rs748753352 3011 dbSNP
rs1388316347 3014 dbSNP
rs533357571 3033 dbSNP
rs1264730111 3046 dbSNP
rs1383434772 3051 dbSNP
rs879794241 3053 dbSNP
rs1490167217 3059 dbSNP
rs1244978333 3061 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions Hela
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1048188. RNA binding protein: AGO2. Condition:Hela_AGO2_CLIP_ptb_knockdown ...

- Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al., 2013, Cell.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' cgAGACGAGUC-U--UGAUGUGAg 5'
            |:|| |||| |  | |||||| 
Target 5' guUUUG-UCAGUAGCAAUACACUa 3'
 		7 - 29
2 
miRNA  3' cgagacgagucUUGAUGugag 5'
                     ||||||    
Target 5' -----------AACUACguuu 3'
 		1 - 10
Article - Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al.
- Cell, 2013
The induction of pluripotency or trans-differentiation of one cell type to another can be accomplished with cell-lineage-specific transcription factors. Here, we report that repression of a single RNA binding polypyrimidine-tract-binding (PTB) protein, which occurs during normal brain development via the action of miR-124, is sufficient to induce trans-differentiation of fibroblasts into functional neurons. Besides its traditional role in regulated splicing, we show that PTB has a previously undocumented function in the regulation of microRNA functions, suppressing or enhancing microRNA targeting by competitive binding on target mRNA or altering local RNA secondary structure. A key event during neuronal induction is the relief of PTB-mediated blockage of microRNA action on multiple components of the REST complex, thereby derepressing a large array of neuronal genes, including miR-124 and multiple neuronal-specific transcription factors, in nonneuronal cells. This converts a negative feedback loop to a positive one to elicit cellular reprogramming to the neuronal lineage.
LinkOut: [PMID: 23313552]
CLIP-seq Support 1 for dataset GSM1048188
Method / RBP HITS-CLIP / AGO2
Cell line / Condition Hela / Hela_AGO2_CLIP_ptb_knockdown
Location of target site ENST00000310981.4 | 3UTR | AACUACGUUUUGUCAGUAGCAAUACACUAGGAAGUA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23313552 / GSE42701
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
67 hsa-miR-4280 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT065612 DAZAP2 DAZ associated protein 2 2 10
MIRT084985 BACH1 BTB domain and CNC homolog 1 2 2
MIRT088053 UBXN2A UBX domain protein 2A 2 4
MIRT097327 SCAMP1 secretory carrier membrane protein 1 2 2
MIRT099148 MYLIP myosin regulatory light chain interacting protein 2 12
MIRT127042 FAM208B family with sequence similarity 208 member B 2 4
MIRT140479 BNIP2 BCL2 interacting protein 2 2 6
MIRT154889 GNAS GNAS complex locus 2 4
MIRT187983 MBD6 methyl-CpG binding domain protein 6 2 2
MIRT190440 EIF5 eukaryotic translation initiation factor 5 2 2
MIRT240673 GAPVD1 GTPase activating protein and VPS9 domains 1 2 2
MIRT295049 EVI5L ecotropic viral integration site 5 like 2 2
MIRT324749 ACER2 alkaline ceramidase 2 2 2
MIRT366075 FAM127A retrotransposon Gag like 8C 2 4
MIRT442625 LOX lysyl oxidase 2 2
MIRT445224 TYRP1 tyrosinase related protein 1 2 2
MIRT448967 CCNT2 cyclin T2 2 4
MIRT450137 PFN4 profilin family member 4 2 2
MIRT464350 USP46 ubiquitin specific peptidase 46 2 2
MIRT470460 PPP1R15B protein phosphatase 1 regulatory subunit 15B 2 2
MIRT473691 MAPK8 mitogen-activated protein kinase 8 2 4
MIRT480188 CALM2 calmodulin 2 2 6
MIRT486355 PCBD2 pterin-4 alpha-carbinolamine dehydratase 2 2 2
MIRT486708 TROVE2 TROVE domain family member 2 2 4
MIRT488337 SCD stearoyl-CoA desaturase 2 2
MIRT489322 PEX26 peroxisomal biogenesis factor 26 2 2
MIRT491791 ZNF24 zinc finger protein 24 2 2
MIRT491970 USP37 ubiquitin specific peptidase 37 2 2
MIRT492029 TWF1 twinfilin actin binding protein 1 2 4
MIRT492063 TMEM245 transmembrane protein 245 2 2
MIRT492247 SLC39A9 solute carrier family 39 member 9 2 2
MIRT492254 SLC35F5 solute carrier family 35 member F5 2 2
MIRT492592 PPIL4 peptidylprolyl isomerase like 4 2 2
MIRT493436 KAT7 lysine acetyltransferase 7 2 2
MIRT493470 IPMK inositol polyphosphate multikinase 2 2
MIRT493639 HECTD1 HECT domain E3 ubiquitin protein ligase 1 2 2
MIRT493919 FAM127B retrotransposon Gag like 8A 2 4
MIRT494639 ARNTL aryl hydrocarbon receptor nuclear translocator like 2 2
MIRT500032 ABCF2 ATP binding cassette subfamily F member 2 2 8
MIRT504589 ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide 2 4
MIRT505535 SP4 Sp4 transcription factor 2 6
MIRT507539 DNAJB6 DnaJ heat shock protein family (Hsp40) member B6 2 6
MIRT508846 TMCO1 transmembrane and coiled-coil domains 1 2 4
MIRT510488 YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta 2 2
MIRT511402 IFNAR2 interferon alpha and beta receptor subunit 2 2 6
MIRT523252 HIST1H2AH histone cluster 1 H2A family member h 2 2
MIRT525939 C11orf74 chromosome 11 open reading frame 74 2 2
MIRT531453 HSD17B12 hydroxysteroid 17-beta dehydrogenase 12 2 2
MIRT533317 UNKL unkempt family like zinc finger 2 2
MIRT541034 STRBP spermatid perinuclear RNA binding protein 2 8
MIRT546734 RNF217 ring finger protein 217 2 2
MIRT555125 PTPRJ protein tyrosine phosphatase, receptor type J 2 2
MIRT556105 MOAP1 modulator of apoptosis 1 2 2
MIRT560205 AK4 adenylate kinase 4 2 2
MIRT561087 LLPH LLP homolog, long-term synaptic facilitation 2 2
MIRT566967 LBR lamin B receptor 2 2
MIRT567344 H3F3B H3 histone family member 3B 2 2
MIRT567863 DCAF12 DDB1 and CUL4 associated factor 12 2 2
MIRT574449 SCML2 Scm polycomb group protein like 2 2 2
MIRT575700 Map1b microtubule-associated protein 1B 2 2
MIRT651432 YIPF6 Yip1 domain family member 6 2 2
MIRT659728 CCDC93 coiled-coil domain containing 93 2 2
MIRT686937 SFT2D3 SFT2 domain containing 3 2 2
MIRT699385 SLC30A6 solute carrier family 30 member 6 2 2
MIRT710287 CSNK1G3 casein kinase 1 gamma 3 2 2
MIRT715123 PANK3 pantothenate kinase 3 2 2
MIRT721847 VLDLR very low density lipoprotein receptor 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4280 Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)
hsa-miR-4280 Platinum 23939 resistant tissue
hsa-miR-4280 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-4280 Neoadjuvant chemotherapy resistant tissue (breast cancer)
hsa-miR-4280 Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)

Error report submission