pre-miRNA Information
pre-miRNA hsa-mir-16-2   
Genomic Coordinates chr3: 160404745 - 160404825
Description Homo sapiens miR-16-2 stem-loop
Comment This entry represents a second putative hairpin precursor sequence for miR-16, located on chromosome 3 (see also MIR:MI0000070). The sequence was previously named mir-16-3 here and in references .
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-16-2-3p
Sequence 53| CCAAUAUUACUGUGCUGCUUUA |74
Evidence Experimental
Experiments Cloned
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN30477465 2 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs746992239 2 dbSNP
rs775368833 4 dbSNP
rs373202341 10 dbSNP
rs768780684 13 dbSNP
rs1341798864 22 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol AGMAT   
Synonyms -
Description agmatinase
Transcript NM_024758   
Expression
Putative miRNA Targets on AGMAT
3'UTR of AGMAT
(miRNA target sites are highlighted)
>AGMAT|NM_024758|3'UTR
   1 GTCTTGTGCTCTTCAAGACAAAACAGATTGCGTCGCTGACAAGTTCTCAAGAAGAACTTATGAGTAAGCAGTCTGAGAAC
  81 TAAAGAGTTTATGCCAAGAAAACTTTCTGCTGAAAGTGTCATTGCTGGCTGTGAAGTCGGGATAATCAGTAGAATTCTCA
 161 CCCAAACAGCAACATTTCTAAGGAACTTGGATTAATTGGGGGAAAAAAAAAGGAGTACTTGTACTGCTTTGATTTTTTTT
 241 CCTTTGATGAAAGATGGAGGATAAAGGGGAAGTGAGGAGAATTTCTTTCAAGATTATCTAAACATTAGAAACATGACATT
 321 TAAAAAAACTATGAAATAATACTGTATAAGCATTCCATATTTCTATATCTTCCTTTTAAACATTTTTTTTTTTGAGATAG
 401 AGTTTTGCTTGTCACCCAGGCTGGAGTGCAATGGCATGATCTCGGTTCATTGCAACCTCCGCCTCCCGAGTTCAATCGAT
 481 TCTCCTGCCTCAGCCTCCTGAGTACCTGGGATTACAGGTGCCTGCCACCACGCCTGGCTAATTTTTGTATTTTTAGTAGA
 561 GACAGGGTTTCACCACATTGGCCAGGCTGGTCTTGAACTCCTGACCTAAGGTGATCCGCCCGCCTCAGCCTCCTTAAAGT
 641 GCTGGGATTACAGGCATGAGCCACCGCACCCAGCCGCTTTTTAAAATTTTGATGATCTGCTTCCTAGAGTATTGAGTATC
 721 TTCCTTTAAACTACAGCTCCTCCTCGGACGCTGCAGTGAGCTGAGATCGCACCACTGCACTCCAGCCTGGGTGCCAGAGC
 801 AAGACTCCATCTCAAAAAAAAAAAAAAAAAATACAGCTTCTCCTATGAGGTGCTTAGGGCTGCATCTTGGTTTTAGGACC
 881 ACTGTGAACGTAAGTAAAAAGTATAAAGTAACACGGAGAGCCTAATGAAGAAACTTCTTGCTCAGAGGCCTAGAAGGGTA
 961 CACAAAATGTCTTCTAAACTAGAAAACCTAAGGCTGGACACGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGGGGCGG
1041 AGGTGGGCAGATCACTTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGTGAAAACCCATCTCTACTGAAAATACA
1121 GAAGTTAGCTGGGCGTGGTGGCGCGTGCCTATAGTCCCAGCTACTCAGGAAGCTGAGGCAGGGGCATTGCTTGAACCCGG
1201 GAGGTGGAGGTTGCAGTGAGCTGAGGTCATGCCACTACACTCCAGCCTGGGTGACAGAGTGAGACTCCGTCTCCAAAAAA
1281 AAAAAAAAAAAAAAAAAAGCAGGCCGGACCCAGTGGCTCACGCCTGTAATCCCAGGCCTAGGCGGGAGGATCACCTGAGG
1361 TCAGGAGTTCAAGACCAGCCTGGCCAACATGGTGAAACCCCGTCTCTACTAAAAAACAAAACAAAACAAAACAAAACAAA
1441 AAAACCCCAGAAAACAAAACAAAACTGGAAAATGTCAGCTGGGCTTTTTTTTTTTTTTTTTTTTCTGAGATGGAGTCTCG
1521 CTCTGTCCCCCAGGCTGGAGTGCAGTGGCCCGATCTTAGCTCACTGCAATCTCCGCCTCCTGGGTTCAAGCAATTCTGCT
1601 GCCTCAGCCTCCTGAGTAGCTAGAATTACAGTCATGCGTCACCACGCCCGGCTAATTTTTGTATTTTTAGTAGAGACGGG
1681 GTTTCACCATGTTGGCCAGGCTGGCAGCTGGGCTCTTAATGTTACTTATTGTAACTCACTTCCTGTAAGACTCAATCTAC
1761 TCTTCAAGTTGATGTACCCTCTATGACTGTAATTCCTGAAATCTGCAGTTATGCTGTGGTGATCTTAAGCGTGTCTTGAG
1841 TTCCATGCAAATTCAATTCTGTTGATAATGTGTCCATAATCAAATCATCATCTTGCAATGCAAGGGCTACCCCATAATTA
1921 TCAGACATTAAAATAGTTTATTTCTTTTTCCA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' auuuCGUCGUGUCAUUAUAACc 5'
              ||  | :|| |:||||| 
Target 5' atctGCTTCCTAG-AGTATTGa 3'
695 - 715 133.00 -6.30
2
miRNA  3' auuUCGUCGUGUC----AUUAUAAcc 5'
             :|||||  :|    ||||:||  
Target 5' gctGGCAGCTGGGCTCTTAATGTTac 3'
1700 - 1725 121.00 -7.30
3
miRNA  3' auuUCGU-CGUGUC-AUUAUAAcc 5'
             | || || |:| |||| ||  
Target 5' gtcACCACGCCCGGCTAATTTTtg 3'
1638 - 1661 107.00 -7.10
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN31483685 17 COSMIC
COSN31560268 28 COSMIC
COSN26579987 31 COSMIC
COSN31501584 34 COSMIC
COSN31603778 35 COSMIC
COSN31528785 51 COSMIC
COSN31483671 54 COSMIC
COSN31560460 69 COSMIC
COSN30481145 75 COSMIC
COSN31553109 85 COSMIC
COSN30495165 121 COSMIC
COSN31610383 202 COSMIC
COSN28840131 203 COSMIC
COSN30528433 203 COSMIC
COSN16120370 317 COSMIC
COSN6507759 326 COSMIC
COSN20094380 382 COSMIC
COSN27734056 394 COSMIC
COSN20090149 462 COSMIC
COSN27989768 663 COSMIC
COSN21818721 1017 COSMIC
COSN25722848 1355 COSMIC
COSN5732609 1402 COSMIC
COSN5732606 1842 COSMIC
COSN31529583 1933 COSMIC
rs571122175 393 GWAS
rs141398135 666 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1228887176 10 dbSNP
rs748405733 12 dbSNP
rs1282299631 16 dbSNP
rs370420853 20 dbSNP
rs1351144337 24 dbSNP
rs376236435 29 dbSNP
rs554047745 31 dbSNP
rs780613590 32 dbSNP
rs756519417 33 dbSNP
rs751102238 34 dbSNP
rs373488895 35 dbSNP
rs1020068542 38 dbSNP
rs762531374 39 dbSNP
rs752456386 40 dbSNP
rs1443675900 41 dbSNP
rs1183969597 43 dbSNP
rs1481867234 47 dbSNP
rs190399856 61 dbSNP
rs540255778 63 dbSNP
rs1421710876 71 dbSNP
rs1378255922 75 dbSNP
rs929812485 76 dbSNP
rs1429241044 77 dbSNP
rs1255537752 80 dbSNP
rs1182005830 83 dbSNP
rs1239124071 84 dbSNP
rs1184827240 85 dbSNP
rs1441317027 87 dbSNP
rs1261759105 98 dbSNP
rs1462789465 99 dbSNP
rs1487068225 112 dbSNP
rs1032545187 113 dbSNP
rs1244129766 116 dbSNP
rs918404444 117 dbSNP
rs1286439266 118 dbSNP
rs1243189307 122 dbSNP
rs1001088608 127 dbSNP
rs868213035 129 dbSNP
rs1479853479 138 dbSNP
rs549405171 139 dbSNP
rs1297420848 141 dbSNP
rs529205678 145 dbSNP
rs1415933999 150 dbSNP
rs1161417728 154 dbSNP
rs572726688 164 dbSNP
rs761118302 165 dbSNP
rs1195146370 167 dbSNP
rs1476669367 169 dbSNP
rs1047165877 170 dbSNP
rs1216397612 184 dbSNP
rs547257359 184 dbSNP
rs919769673 196 dbSNP
rs55654724 202 dbSNP
rs527506857 203 dbSNP
rs538739214 203 dbSNP
rs1022279224 204 dbSNP
rs1243326357 211 dbSNP
rs111577791 212 dbSNP
rs554869216 215 dbSNP
rs956420885 220 dbSNP
rs1035821334 224 dbSNP
rs565118624 227 dbSNP
rs1336969077 235 dbSNP
rs375350467 241 dbSNP
rs779628959 243 dbSNP
rs544863399 252 dbSNP
rs1397109870 256 dbSNP
rs1394033398 259 dbSNP
rs186331666 266 dbSNP
rs1476537974 267 dbSNP
rs988552091 271 dbSNP
rs1199733397 272 dbSNP
rs778117600 280 dbSNP
rs906273555 284 dbSNP
rs1001036171 289 dbSNP
rs1044792467 292 dbSNP
rs1446683883 293 dbSNP
rs1011901837 302 dbSNP
rs888091511 314 dbSNP
rs748226692 316 dbSNP
rs1178249949 325 dbSNP
rs181507186 326 dbSNP
rs1253074576 329 dbSNP
rs758186793 332 dbSNP
rs1018566602 354 dbSNP
rs750280711 356 dbSNP
rs1272920659 358 dbSNP
rs918425158 365 dbSNP
rs1040849551 369 dbSNP
rs1336320022 379 dbSNP
rs34201882 382 dbSNP
rs71572165 383 dbSNP
rs542645314 384 dbSNP
rs985457048 388 dbSNP
rs898293538 391 dbSNP
rs1360970427 393 dbSNP
rs1239115468 394 dbSNP
rs1415877466 394 dbSNP
rs1422610377 394 dbSNP
rs36051155 394 dbSNP
rs397979324 394 dbSNP
rs571122175 394 dbSNP
rs1216508674 398 dbSNP
rs1038219453 400 dbSNP
rs1181091162 400 dbSNP
rs1237661669 403 dbSNP
rs1237854389 403 dbSNP
rs937193113 406 dbSNP
rs969133450 407 dbSNP
rs573637851 410 dbSNP
rs71572164 413 dbSNP
rs1045675072 414 dbSNP
rs188083413 416 dbSNP
rs956280624 424 dbSNP
rs912912179 436 dbSNP
rs1035893265 437 dbSNP
rs757282233 443 dbSNP
rs1301200192 444 dbSNP
rs925737625 451 dbSNP
rs1357116925 457 dbSNP
rs753910644 460 dbSNP
rs1023376768 461 dbSNP
rs1366237062 467 dbSNP
rs540900142 468 dbSNP
rs964267012 475 dbSNP
rs1380221053 476 dbSNP
rs111441028 477 dbSNP
rs1484266188 478 dbSNP
rs1048025438 482 dbSNP
rs987083570 483 dbSNP
rs955532765 484 dbSNP
rs994527614 491 dbSNP
rs111820574 492 dbSNP
rs898575088 500 dbSNP
rs1229911576 505 dbSNP
rs1202189174 515 dbSNP
rs1376378701 521 dbSNP
rs1301685147 522 dbSNP
rs1400242970 523 dbSNP
rs1040882231 525 dbSNP
rs943863645 531 dbSNP
rs1204222290 532 dbSNP
rs1001757774 533 dbSNP
rs775760521 535 dbSNP
rs1166142291 562 dbSNP
rs1348022881 565 dbSNP
rs1262280538 577 dbSNP
rs889585680 578 dbSNP
rs1478307397 583 dbSNP
rs1344630982 587 dbSNP
rs1214241436 603 dbSNP
rs1487852044 611 dbSNP
rs1281343954 612 dbSNP
rs538052488 616 dbSNP
rs569339147 617 dbSNP
rs538988089 618 dbSNP
rs1311463380 621 dbSNP
rs1399188134 622 dbSNP
rs947453399 630 dbSNP
rs183502615 645 dbSNP
rs891420076 655 dbSNP
rs1398958556 657 dbSNP
rs1384743124 660 dbSNP
rs1459947436 665 dbSNP
rs141398135 666 dbSNP
rs1465892697 667 dbSNP
rs11587541 668 dbSNP
rs928852685 675 dbSNP
rs117761427 676 dbSNP
rs970232350 677 dbSNP
rs1487503695 681 dbSNP
rs1023100833 686 dbSNP
rs1191770034 690 dbSNP
rs1198784919 692 dbSNP
rs911412829 696 dbSNP
rs1444762217 711 dbSNP
rs1217642245 717 dbSNP
rs1263488526 718 dbSNP
rs1205319771 721 dbSNP
rs987419948 728 dbSNP
rs1388853665 744 dbSNP
rs1260969174 745 dbSNP
rs990985118 746 dbSNP
rs1324101701 749 dbSNP
rs952488870 750 dbSNP
rs1025936255 759 dbSNP
rs1428802779 768 dbSNP
rs1328244641 776 dbSNP
rs972727254 783 dbSNP
rs1378420999 786 dbSNP
rs1178016108 804 dbSNP
rs1431209322 806 dbSNP
rs1319287925 811 dbSNP
rs75693268 813 dbSNP
rs1404406176 814 dbSNP
rs1458987669 814 dbSNP
rs1027107088 827 dbSNP
rs1178951769 828 dbSNP
rs1470598939 831 dbSNP
rs1197450098 832 dbSNP
rs1241521158 832 dbSNP
rs1257368391 832 dbSNP
rs1310840526 832 dbSNP
rs1340581638 832 dbSNP
rs549770999 832 dbSNP
rs58974289 832 dbSNP
rs144631679 833 dbSNP
rs1423612428 834 dbSNP
rs1379747262 842 dbSNP
rs1166654778 847 dbSNP
rs962730222 849 dbSNP
rs1390861694 852 dbSNP
rs993832627 855 dbSNP
rs1474162585 858 dbSNP
rs1017020069 861 dbSNP
rs1464702096 862 dbSNP
rs1394258824 865 dbSNP
rs148293156 874 dbSNP
rs1019505399 877 dbSNP
rs905671310 883 dbSNP
rs191355230 889 dbSNP
rs6700212 890 dbSNP
rs1277503565 891 dbSNP
rs1280138806 892 dbSNP
rs1482690253 892 dbSNP
rs1205392559 897 dbSNP
rs1241322331 904 dbSNP
rs891710306 907 dbSNP
rs1052988237 914 dbSNP
rs935654392 915 dbSNP
rs1461600537 926 dbSNP
rs1272256423 930 dbSNP
rs1341181943 934 dbSNP
rs1314863674 938 dbSNP
rs904209195 939 dbSNP
rs1375061513 943 dbSNP
rs573446725 945 dbSNP
rs1421260589 952 dbSNP
rs1358335333 954 dbSNP
rs1157958810 957 dbSNP
rs1473047207 963 dbSNP
rs189133613 976 dbSNP
rs371023363 980 dbSNP
rs1270807140 983 dbSNP
rs1184761477 986 dbSNP
rs1474715708 986 dbSNP
rs144408882 987 dbSNP
rs773777895 992 dbSNP
rs1489489154 996 dbSNP
rs1053552384 999 dbSNP
rs1380788104 1001 dbSNP
rs149637641 1005 dbSNP
rs377636574 1009 dbSNP
rs1267370438 1011 dbSNP
rs934193311 1015 dbSNP
rs1355115276 1020 dbSNP
rs928590846 1023 dbSNP
rs981693566 1025 dbSNP
rs918825835 1027 dbSNP
rs1453915515 1030 dbSNP
rs948917082 1031 dbSNP
rs185733928 1033 dbSNP
rs1160993175 1038 dbSNP
rs984975166 1038 dbSNP
rs1423661987 1039 dbSNP
rs952595815 1049 dbSNP
rs1026723504 1068 dbSNP
rs972868669 1071 dbSNP
rs1412083477 1072 dbSNP
rs1398048147 1073 dbSNP
rs1452764054 1077 dbSNP
rs962676337 1084 dbSNP
rs192890093 1094 dbSNP
rs1383071911 1099 dbSNP
rs575716843 1100 dbSNP
rs1008104870 1103 dbSNP
rs555853943 1107 dbSNP
rs1024847609 1109 dbSNP
rs1269446854 1119 dbSNP
rs145057318 1122 dbSNP
rs1202395448 1123 dbSNP
rs535583705 1129 dbSNP
rs138508310 1131 dbSNP
rs904158180 1132 dbSNP
rs1463789700 1134 dbSNP
rs1418348673 1135 dbSNP
rs1167745617 1138 dbSNP
rs112209125 1142 dbSNP
rs188851811 1143 dbSNP
rs1038703914 1144 dbSNP
rs893238513 1145 dbSNP
rs890209547 1147 dbSNP
rs1246956434 1151 dbSNP
rs1436329034 1157 dbSNP
rs1053221687 1171 dbSNP
rs1373080405 1175 dbSNP
rs1272537348 1179 dbSNP
rs1051974408 1180 dbSNP
rs1346899328 1181 dbSNP
rs998900110 1191 dbSNP
rs539442121 1198 dbSNP
rs1233497181 1199 dbSNP
rs934135686 1200 dbSNP
rs112486069 1205 dbSNP
rs59513462 1206 dbSNP
rs948989994 1208 dbSNP
rs1334434010 1228 dbSNP
rs1423497607 1230 dbSNP
rs560327297 1237 dbSNP
rs540325591 1238 dbSNP
rs1454273033 1240 dbSNP
rs1381436804 1246 dbSNP
rs1180644019 1257 dbSNP
rs780692514 1257 dbSNP
rs1479712578 1259 dbSNP
rs1232333783 1261 dbSNP
rs868657825 1268 dbSNP
rs1406988142 1272 dbSNP
rs1175211458 1273 dbSNP
rs1471034561 1274 dbSNP
rs33990724 1275 dbSNP
rs1233450019 1276 dbSNP
rs1354378828 1290 dbSNP
rs1198556435 1296 dbSNP
rs1311396791 1297 dbSNP
rs1491200238 1298 dbSNP
rs866938016 1298 dbSNP
rs1161007335 1299 dbSNP
rs1182510159 1299 dbSNP
rs1255637458 1299 dbSNP
rs1341529545 1299 dbSNP
rs1361518421 1299 dbSNP
rs1373233036 1299 dbSNP
rs1407370217 1299 dbSNP
rs1417784579 1299 dbSNP
rs1424359005 1299 dbSNP
rs1434464317 1299 dbSNP
rs1473937333 1299 dbSNP
rs1488510438 1299 dbSNP
rs1491118307 1299 dbSNP
rs781149544 1299 dbSNP
rs941598917 1299 dbSNP
rs1290942842 1301 dbSNP
rs191893417 1305 dbSNP
rs1223538095 1306 dbSNP
rs34414168 1315 dbSNP
rs751034169 1321 dbSNP
rs1415711275 1322 dbSNP
rs970484811 1324 dbSNP
rs1265132908 1327 dbSNP
rs1225890965 1334 dbSNP
rs1485524875 1335 dbSNP
rs1247192044 1336 dbSNP
rs1374474566 1337 dbSNP
rs1283263759 1340 dbSNP
rs917326762 1341 dbSNP
rs916147973 1342 dbSNP
rs1403587583 1343 dbSNP
rs1319544158 1344 dbSNP
rs1343133355 1344 dbSNP
rs1304364846 1347 dbSNP
rs1436772159 1348 dbSNP
rs1344302262 1350 dbSNP
rs1049726587 1355 dbSNP
rs1402276180 1356 dbSNP
rs1412412626 1357 dbSNP
rs1175646753 1359 dbSNP
rs879793291 1371 dbSNP
rs993333910 1383 dbSNP
rs1191785547 1385 dbSNP
rs1392387419 1389 dbSNP
rs1485577376 1393 dbSNP
rs919398937 1395 dbSNP
rs1240621192 1398 dbSNP
rs972510242 1400 dbSNP
rs1374971554 1401 dbSNP
rs549176757 1402 dbSNP
rs1317920139 1412 dbSNP
rs1192855678 1417 dbSNP
rs1425558768 1417 dbSNP
rs1467040524 1422 dbSNP
rs1262865353 1428 dbSNP
rs1222224529 1432 dbSNP
rs1249242518 1437 dbSNP
rs912261521 1438 dbSNP
rs1284465441 1440 dbSNP
rs1000035063 1442 dbSNP
rs1017979022 1442 dbSNP
rs1302341275 1442 dbSNP
rs567517488 1442 dbSNP
rs567655345 1442 dbSNP
rs1398666230 1444 dbSNP
rs1007208873 1445 dbSNP
rs113730136 1445 dbSNP
rs1296698476 1445 dbSNP
rs529033090 1445 dbSNP
rs890148002 1445 dbSNP
rs1051496744 1447 dbSNP
rs968496345 1450 dbSNP
rs953986412 1452 dbSNP
rs398073797 1465 dbSNP
rs75849790 1465 dbSNP
rs1028227413 1466 dbSNP
rs1194882881 1466 dbSNP
rs1247762164 1466 dbSNP
rs1257020644 1469 dbSNP
rs1011878818 1472 dbSNP
rs957246443 1478 dbSNP
rs1031888543 1479 dbSNP
rs560286438 1483 dbSNP
rs1337618295 1485 dbSNP
rs993267068 1485 dbSNP
rs1304890616 1490 dbSNP
rs1391098802 1502 dbSNP
rs897290524 1504 dbSNP
rs1276139046 1505 dbSNP
rs1314539224 1505 dbSNP
rs1361616680 1505 dbSNP
rs1374577644 1505 dbSNP
rs1432610439 1505 dbSNP
rs1455226873 1505 dbSNP
rs560322313 1505 dbSNP
rs866714139 1505 dbSNP
rs1389151667 1506 dbSNP
rs1218005993 1507 dbSNP
rs1279974841 1507 dbSNP
rs1353455400 1508 dbSNP
rs1335764801 1513 dbSNP
rs1468181827 1516 dbSNP
rs1431431368 1518 dbSNP
rs1238384947 1519 dbSNP
rs1176698203 1520 dbSNP
rs112090737 1523 dbSNP
rs941546651 1527 dbSNP
rs1298564198 1528 dbSNP
rs553297412 1528 dbSNP
rs1188536041 1530 dbSNP
rs370368036 1531 dbSNP
rs910114743 1536 dbSNP
rs187236868 1542 dbSNP
rs907284457 1551 dbSNP
rs564818499 1552 dbSNP
rs1162354085 1557 dbSNP
rs1202231953 1558 dbSNP
rs376685319 1574 dbSNP
rs948719228 1575 dbSNP
rs1257133404 1592 dbSNP
rs1194344252 1603 dbSNP
rs1227320169 1613 dbSNP
rs1260237141 1629 dbSNP
rs1216748091 1631 dbSNP
rs1335586696 1632 dbSNP
rs1012910709 1633 dbSNP
rs894440434 1635 dbSNP
rs577739659 1637 dbSNP
rs1278648540 1638 dbSNP
rs1432607832 1639 dbSNP
rs1324418636 1640 dbSNP
rs11587005 1641 dbSNP
rs575874145 1645 dbSNP
rs1049338947 1646 dbSNP
rs561981842 1649 dbSNP
rs919438976 1650 dbSNP
rs924732374 1654 dbSNP
rs1423858311 1660 dbSNP
rs1168906006 1669 dbSNP
rs978562585 1673 dbSNP
rs1036479205 1677 dbSNP
rs542012508 1678 dbSNP
rs1469261507 1680 dbSNP
rs1408002311 1685 dbSNP
rs867669861 1687 dbSNP
rs1211857144 1706 dbSNP
rs1468241109 1715 dbSNP
rs968547050 1720 dbSNP
rs912294062 1721 dbSNP
rs1303380045 1728 dbSNP
rs111845799 1729 dbSNP
rs1269317344 1737 dbSNP
rs758014443 1740 dbSNP
rs1373093346 1755 dbSNP
rs1300679902 1759 dbSNP
rs920905670 1767 dbSNP
rs1439495337 1769 dbSNP
rs1352841698 1773 dbSNP
rs1400334862 1777 dbSNP
rs954380781 1778 dbSNP
rs1394804938 1782 dbSNP
rs990091011 1784 dbSNP
rs1167691462 1788 dbSNP
rs1450148369 1813 dbSNP
rs1455112969 1818 dbSNP
rs1397400386 1823 dbSNP
rs1192249487 1830 dbSNP
rs757929643 1831 dbSNP
rs1233461934 1833 dbSNP
rs1206905197 1836 dbSNP
rs1436277492 1838 dbSNP
rs1030416491 1846 dbSNP
rs1272112491 1846 dbSNP
rs993214848 1852 dbSNP
rs1301190676 1857 dbSNP
rs1233427534 1873 dbSNP
rs745605365 1884 dbSNP
rs957507636 1890 dbSNP
rs115545913 1899 dbSNP
rs1016042773 1900 dbSNP
rs998669296 1910 dbSNP
rs1334768944 1914 dbSNP
rs971499297 1914 dbSNP
rs1257246043 1920 dbSNP
rs1302668668 1921 dbSNP
rs888623416 1924 dbSNP
rs1044627419 1933 dbSNP
rs553000494 1934 dbSNP
rs137976827 1940 dbSNP
rs549660449 1944 dbSNP
rs1468857056 1948 dbSNP
rs1232504212 1950 dbSNP
rs531065162 1952 dbSNP
rs1188848816 1953 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions Hela
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1048187. RNA binding protein: AGO2. Condition:Hela_AGO2_CLIP_control HITS-CLIP data was present in GSM1048188. RNA binding protein: AGO2. Condition:Hela_AGO2_CLIP_ptb_knockdown ...

- Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al., 2013, Cell.

Article - Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al.
- Cell, 2013
The induction of pluripotency or trans-differentiation of one cell type to another can be accomplished with cell-lineage-specific transcription factors. Here, we report that repression of a single RNA binding polypyrimidine-tract-binding (PTB) protein, which occurs during normal brain development via the action of miR-124, is sufficient to induce trans-differentiation of fibroblasts into functional neurons. Besides its traditional role in regulated splicing, we show that PTB has a previously undocumented function in the regulation of microRNA functions, suppressing or enhancing microRNA targeting by competitive binding on target mRNA or altering local RNA secondary structure. A key event during neuronal induction is the relief of PTB-mediated blockage of microRNA action on multiple components of the REST complex, thereby derepressing a large array of neuronal genes, including miR-124 and multiple neuronal-specific transcription factors, in nonneuronal cells. This converts a negative feedback loop to a positive one to elicit cellular reprogramming to the neuronal lineage.
LinkOut: [PMID: 23313552]
CLIP-seq Support 1 for dataset GSM1048187
Method / RBP HITS-CLIP / AGO2
Cell line / Condition Hela / Hela_AGO2_CLIP_control
Location of target site ENST00000375826.3 | 3UTR | UGAUAAUCCCAGCACUUUGGGAGGCCAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23313552 / GSE42701
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1048188
Method / RBP HITS-CLIP / AGO2
Cell line / Condition Hela / Hela_AGO2_CLIP_ptb_knockdown
Location of target site ENST00000375826.3 | 3UTR | UGAUAAUCCCAGCACUUUGGGAGGCC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23313552 / GSE42701
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE28544 Breast cancer -0.545 2.9e-3 -0.615 6.9e-4 24 Click to see details
GSE28260 Renal cortex and medulla -0.573 2.0e-2 -0.692 4.4e-3 13 Click to see details
GSE42095 Differentiated embryonic stem cells 0.422 2.2e-2 0.420 2.3e-2 23 Click to see details
GSE35602 Colorectal cancer stromal tissue 0.385 2.9e-2 0.278 8.9e-2 25 Click to see details
GSE19536 Breast cancer 0.148 7.1e-2 0.122 1.1e-1 100 Click to see details
GSE19783 ER- ER- breast cancer 0.161 7.8e-2 0.144 1.0e-1 79 Click to see details
GSE19783 ER+ ER+ breast cancer 0.229 1.7e-1 0.156 2.6e-1 20 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis -0.188 2.1e-1 -0.155 2.6e-1 20 Click to see details
GSE21687 Ependynoma primary tumors 0.073 2.8e-1 0.001 5.0e-1 64 Click to see details
GSE19350 CNS germ cell tumors 0.183 2.8e-1 0.259 2.1e-1 12 Click to see details
GSE38974 Chronic obstructive pulmonary disease -0.077 3.6e-1 -0.073 3.6e-1 25 Click to see details
GSE21032 Prostate cancer 0.033 3.8e-1 0.018 4.4e-1 83 Click to see details
GSE26953 Aortic valvular endothelial cells -0.061 3.9e-1 -0.014 4.7e-1 24 Click to see details
GSE15076 Monocyte-derived dendritic cells 0.104 4.0e-1 0.417 1.3e-1 9 Click to see details
GSE32688 Pancreatic cancer 0.042 4.1e-1 0.027 4.4e-1 32 Click to see details
GSE38226 Liver fibrosis -0.023 4.6e-1 0.086 3.6e-1 21 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
STAD 0.62 0 0.622 0 31 Click to see details
PAAD 0.936 0.03 0.800 0.1 4 Click to see details
BLCA 0.442 0.03 0.356 0.07 18 Click to see details
CHOL -0.598 0.04 -0.383 0.15 9 Click to see details
KIRP -0.301 0.05 -0.167 0.18 32 Click to see details
LUAD 0.396 0.1 0.420 0.09 12 Click to see details
PRAD -0.172 0.12 -0.061 0.34 48 Click to see details
UCEC 0.275 0.13 0.330 0.08 19 Click to see details
CESC -0.908 0.14 -1.000 0.5 3 Click to see details
PCPG 0.872 0.16 1.000 0.5 3 Click to see details
ESCA 0.313 0.17 0.200 0.28 11 Click to see details
BRCA -0.069 0.27 -0.124 0.13 83 Click to see details
KIRC 0.074 0.27 0.074 0.27 68 Click to see details
THCA -0.054 0.34 0.014 0.46 59 Click to see details
LIHC -0.055 0.35 -0.034 0.41 49 Click to see details
LUSC -0.033 0.42 -0.136 0.21 38 Click to see details
KICH -0.035 0.43 -0.086 0.34 25 Click to see details
HNSC 0.017 0.46 -0.049 0.38 42 Click to see details
HNSC 0.017 0.46 -0.049 0.38 42 Click to see details
HNSC 0.017 0.46 -0.049 0.38 42 Click to see details
75 hsa-miR-16-2-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT004488 RARB retinoic acid receptor beta 3 1
MIRT038707 NUCKS1 nuclear casein kinase and cyclin dependent kinase substrate 1 1 1
MIRT057208 PPIF peptidylprolyl isomerase F 2 4
MIRT058726 RSBN1 round spermatid basic protein 1 2 8
MIRT074502 NFATC2IP nuclear factor of activated T-cells 2 interacting protein 2 4
MIRT081544 ZNF431 zinc finger protein 431 2 4
MIRT096893 ERBB2IP erbb2 interacting protein 2 2
MIRT105124 MYC MYC proto-oncogene, bHLH transcription factor 2 2
MIRT107898 PTAR1 protein prenyltransferase alpha subunit repeat containing 1 2 4
MIRT109432 KLHL15 kelch like family member 15 2 6
MIRT166742 PAPD7 poly(A) RNA polymerase D7, non-canonical 2 6
MIRT171257 YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma 2 2
MIRT192760 B2M beta-2-microglobulin 2 2
MIRT194905 RBBP6 RB binding protein 6, ubiquitin ligase 2 8
MIRT215599 SUB1 SUB1 homolog, transcriptional regulator 2 2
MIRT223632 ATP6V1C1 ATPase H+ transporting V1 subunit C1 2 4
MIRT241605 AMOTL1 angiomotin like 1 2 4
MIRT291174 SH3GLB1 SH3 domain containing GRB2 like, endophilin B1 2 2
MIRT444286 ABCG2 ATP binding cassette subfamily G member 2 (Junior blood group) 2 2
MIRT463285 ZFX zinc finger protein, X-linked 2 4
MIRT471759 NUS1 NUS1 dehydrodolichyl diphosphate synthase subunit 2 8
MIRT479611 CDC25A cell division cycle 25A 2 2
MIRT481497 ARL6IP1 ADP ribosylation factor like GTPase 6 interacting protein 1 2 8
MIRT483117 SH3BP5 SH3 domain binding protein 5 2 2
MIRT502279 GRPEL2 GrpE like 2, mitochondrial 2 8
MIRT507838 CCNT1 cyclin T1 2 2
MIRT508179 MTRNR2L6 MT-RNR2-like 6 2 4
MIRT510576 UBE2D3 ubiquitin conjugating enzyme E2 D3 2 6
MIRT517853 RPS4X ribosomal protein S4, X-linked 2 4
MIRT521690 PRKAA1 protein kinase AMP-activated catalytic subunit alpha 1 2 8
MIRT525070 FRK fyn related Src family tyrosine kinase 2 2
MIRT527082 UBE2E3 ubiquitin conjugating enzyme E2 E3 2 2
MIRT529552 EI24 EI24, autophagy associated transmembrane protein 2 2
MIRT530426 SULT1B1 sulfotransferase family 1B member 1 2 2
MIRT533909 TBC1D15 TBC1 domain family member 15 2 2
MIRT536627 IPO7 importin 7 2 2
MIRT537647 ERGIC2 ERGIC and golgi 2 2 4
MIRT538512 CLCN3 chloride voltage-gated channel 3 2 2
MIRT539219 ANP32E acidic nuclear phosphoprotein 32 family member E 2 6
MIRT539348 AGO2 argonaute 2, RISC catalytic component 2 4
MIRT539954 CCT4 chaperonin containing TCP1 subunit 4 2 2
MIRT541208 HOXA10 homeobox A10 2 2
MIRT543216 TMEM117 transmembrane protein 117 2 2
MIRT543399 DROSHA drosha ribonuclease III 2 2
MIRT546648 RPS6KA5 ribosomal protein S6 kinase A5 2 2
MIRT546852 RAB1A RAB1A, member RAS oncogene family 2 2
MIRT549917 MRPS30 mitochondrial ribosomal protein S30 2 2
MIRT552998 USP46 ubiquitin specific peptidase 46 2 2
MIRT555254 PREPL prolyl endopeptidase-like 2 2
MIRT555956 NRIP1 nuclear receptor interacting protein 1 2 2
MIRT557095 HOXA9 homeobox A9 2 2
MIRT561396 TUBB2A tubulin beta 2A class IIa 2 2
MIRT561654 RNF219 ring finger protein 219 2 2
MIRT563101 PABPC4L poly(A) binding protein cytoplasmic 4 like 2 2
MIRT565979 RNF44 ring finger protein 44 2 2
MIRT572396 CCDC14 coiled-coil domain containing 14 2 2
MIRT574400 TM9SF3 transmembrane 9 superfamily member 3 2 2
MIRT607623 VSNL1 visinin like 1 2 2
MIRT610645 CTGF connective tissue growth factor 2 2
MIRT623379 LPP LIM domain containing preferred translocation partner in lipoma 2 2
MIRT624687 AR androgen receptor 2 2
MIRT632089 ALDH1A2 aldehyde dehydrogenase 1 family member A2 2 2
MIRT644216 CBS cystathionine-beta-synthase 2 2
MIRT647841 BID BH3 interacting domain death agonist 2 2
MIRT651649 WASF2 WAS protein family member 2 2 2
MIRT689064 AGMAT agmatinase 2 2
MIRT698150 TNPO1 transportin 1 2 2
MIRT700516 PTPN14 protein tyrosine phosphatase, non-receptor type 14 2 2
MIRT704081 DYRK2 dual specificity tyrosine phosphorylation regulated kinase 2 2 2
MIRT705970 ACBD5 acyl-CoA binding domain containing 5 2 2
MIRT715694 COMMD3-BMI1 COMMD3-BMI1 readthrough 2 2
MIRT717184 BMI1 BMI1 proto-oncogene, polycomb ring finger 2 2
MIRT724607 AP3B1 adaptor related protein complex 3 beta 1 subunit 2 2
MIRT724854 IGFBP5 insulin like growth factor binding protein 5 2 2
MIRT725401 LRIG2 leucine rich repeats and immunoglobulin like domains 2 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-16-2 Diethylstilbestrol approved 448537 Microarray mammosphere-derived epithelial cells (MDEC) 19549897 2009 down-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-16-2-3p Oxaliplatin 6857599 NSC266046 approved resistant High Colorectal Cancer cell line (HCT-116)
hsa-miR-16-2-3p Mitoxantrone 4212 NSC279836 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-miR-16-2-3p Cisplatin 5460033 NSC119875 approved sensitive Low Osteosarcoma cell line (HOS)
hsa-miR-16-2-3p Doxorubicin 31703 NSC123127 approved sensitive Low Osteosarcoma cell line (HOS)
hsa-miR-16-2-3p Paclitaxel 36314 NSC125973 approved sensitive High Non-Small Cell Lung Cancer cell line (H460)
hsa-miR-16-2-3p Bortezomib 387447 NSC681239 approved resistant Low Multiple Myeloma tissue
hsa-miR-16-2-3p Gefitinib 123631 NSC715055 approved sensitive cell line (HCC827)
hsa-miR-16-2-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (CAL-27) (cytosolic RNA)
hsa-miR-16-2-3p Cisplatin 5460033 NSC119875 approved resistant cell line (CAL-27) (total RNA)
hsa-miR-16-2-3p Vemurafenib 42611257 NSC761431 approved sensitive cell line (451Lu)
hsa-miR-16-2-3p Doxorubicin 31703 NSC123127 approved sensitive cell line (BAS)
hsa-miR-16-2-3p Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)
hsa-miR-16-2-3p Sunitinib 5329102 NSC750690 approved resistant tissue (CardB)
hsa-miR-16-2-3p Cisplatin 5460033 NSC119875 approved resistant cell line (HCT8)
hsa-miR-16-2-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (IGROV-1)
hsa-miR-16-2-3p Gemcitabine 60750 NSC613327 approved sensitive cell line (MDA-231)
hsa-miR-16-2-3p Cisplatin 5460033 NSC119875 approved resistant cell line (A549)
hsa-miR-16-2-3p Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR4)

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