pre-miRNA Information
pre-miRNA hsa-mir-758   
Genomic Coordinates chr14: 101026020 - 101026107
Synonyms MIRN758, hsa-mir-758, MIR758
Description Homo sapiens miR-758 stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-758-5p
Sequence 15| GAUGGUUGACCAGAGAGCACAC |36
Evidence Experimental
Experiments SOLiD
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 16 14 + 101026049 29233923 MiREDiBase
A-to-I 21 14 + 101026054 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs372417522 1 dbSNP
rs748092616 2 dbSNP
rs1270901332 4 dbSNP
rs1364206491 5 dbSNP
rs1483583954 8 dbSNP
rs770931807 10 dbSNP
rs776760808 11 dbSNP
rs1360350664 12 dbSNP
rs759742151 13 dbSNP
rs1002938972 15 dbSNP
rs770107042 17 dbSNP
rs369242818 20 dbSNP
rs1217090272 21 dbSNP
rs763341052 22 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol ZNF83   
Synonyms HPF1, ZNF816B
Description zinc finger protein 83
Transcript NM_001105549   
Other Transcripts NM_001105550 , NM_001105551 , NM_001105552 , NM_018300   
Expression
Putative miRNA Targets on ZNF83
3'UTR of ZNF83
(miRNA target sites are highlighted)
>ZNF83|NM_001105549|3'UTR
   1 TGTGGCAGAGTGTTCAGTTAGCATTAAAGCCTTGTAAGACATACAATAATTTATACTGGAGAAAAACTTTGCAAGTATAA
  81 TGAATGTAGCAGAGCCTTTAGTTTTTGTTCAAGGCTTAATAACCGTTAGCTAGACCATAGAGGACAGAAACTTTACTAAT
 161 GTACTGAATGTGGCAAGGTCTTAAGGTAAAATCTGAGACCAGGATTCTTCAAAGAATTCTTGCTGGTGAGAAACCTAACA
 241 AATGTAATGAATGTGGCAAGGTCTTCTGGCACAATTCTCACATTGTACAATATTGCAAAAATTCATGCTTGAGAGAAACA
 321 AAAACACTGAGAGTGGGAAACCATTATGACTTCAAACATTCATCAACATCAGAGAATCCATACTAAAGAGCATTTATAAT
 401 AATTATATGTGATAGAGATTTTCCGCAGGCCAAAGTCTCACTAGGCATCAAAAACTTTTTTGATGAAACCATACAAATGT
 481 AACGTGCATGCTTAAGCTTTTACCCAGGCATCAAAACCGGAACATCACAGGGTTTATACTGGAGAGTAACTACACAAAGA
 561 TAATGTAATAAGCCTTTCAGTGTAATATTCATGATTTTGTCGTGAGAGATCCACTCAATAAAAACCAGGCAAATGTAGTG
 641 AATCTGGAAAAAAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' cacacGAGAGACCA-GUUGGUAg 5'
               :|:|:|| |  |||||| 
Target 5' aaaacTTTTTTGATGAAACCATa 3'
451 - 473 125.00 -9.40
2
miRNA  3' cacacgagagaccagUUGGUAg 5'
                         |||||| 
Target 5' acactgagagtgggaAACCATt 3'
324 - 345 120.00 -11.10
3
miRNA  3' cacACGAG---AGACCAGUUGGUAg 5'
             ||:||    ||   :||||:| 
Target 5' tttTGTTCAAGGCTTAATAACCGTt 3'
103 - 127 115.00 -9.90
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN20079425 30 COSMIC
COSN30530802 37 COSMIC
COSN31486894 41 COSMIC
COSN31570059 43 COSMIC
COSN4891648 46 COSMIC
COSN30534056 54 COSMIC
COSN18716512 125 COSMIC
COSN7448891 162 COSMIC
COSN8975507 320 COSMIC
COSN22620017 553 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs765927489 2 dbSNP
rs1397031613 4 dbSNP
rs1169416430 7 dbSNP
rs200247745 10 dbSNP
rs1368049635 11 dbSNP
rs1318928500 17 dbSNP
rs772811659 22 dbSNP
rs927531991 30 dbSNP
rs1045985127 31 dbSNP
rs186220396 35 dbSNP
rs761459864 42 dbSNP
rs768769071 44 dbSNP
rs1188784429 45 dbSNP
rs768473445 46 dbSNP
rs1182170953 48 dbSNP
rs972726171 69 dbSNP
rs1026396662 70 dbSNP
rs994629893 71 dbSNP
rs1424815765 77 dbSNP
rs1468929921 82 dbSNP
rs963465291 83 dbSNP
rs1173820766 86 dbSNP
rs1407586073 88 dbSNP
rs183356999 96 dbSNP
rs1033388827 97 dbSNP
rs1391275612 102 dbSNP
rs1414603755 107 dbSNP
rs963078768 115 dbSNP
rs909975485 123 dbSNP
rs112408119 124 dbSNP
rs552094689 125 dbSNP
rs1223063356 128 dbSNP
rs1191892137 135 dbSNP
rs1281627343 138 dbSNP
rs1325741584 143 dbSNP
rs533924025 145 dbSNP
rs1231423440 160 dbSNP
rs1046707583 161 dbSNP
rs559722737 169 dbSNP
rs1218597037 173 dbSNP
rs1264264561 174 dbSNP
rs1204115061 179 dbSNP
rs372097471 182 dbSNP
rs1010218040 184 dbSNP
rs1196825526 189 dbSNP
rs190358999 200 dbSNP
rs1157532553 204 dbSNP
rs1046648 207 dbSNP
rs965970823 220 dbSNP
rs936654020 244 dbSNP
rs1298733739 259 dbSNP
rs377307964 260 dbSNP
rs1388051471 279 dbSNP
rs1301518929 282 dbSNP
rs1039740906 283 dbSNP
rs1234271976 284 dbSNP
rs1278994546 286 dbSNP
rs10383 289 dbSNP
rs772261150 292 dbSNP
rs1371566906 294 dbSNP
rs1287441316 306 dbSNP
rs1310313845 319 dbSNP
rs1433391600 320 dbSNP
rs1054252742 323 dbSNP
rs1451767157 323 dbSNP
rs1180681119 325 dbSNP
rs575518895 329 dbSNP
rs1470886426 330 dbSNP
rs556973863 332 dbSNP
rs1159166731 336 dbSNP
rs1176825409 337 dbSNP
rs1422479617 348 dbSNP
rs1435000123 348 dbSNP
rs1391229287 364 dbSNP
rs1387500563 369 dbSNP
rs929206228 373 dbSNP
rs1334048231 378 dbSNP
rs1449182091 390 dbSNP
rs1187560337 395 dbSNP
rs1310595107 396 dbSNP
rs906058952 402 dbSNP
rs371761063 404 dbSNP
rs571126369 404 dbSNP
rs1267562693 406 dbSNP
rs950277452 407 dbSNP
rs545314278 408 dbSNP
rs1248049453 413 dbSNP
rs1253687083 417 dbSNP
rs13103 424 dbSNP
rs1046679 425 dbSNP
rs879469146 426 dbSNP
rs909953240 426 dbSNP
rs1165401629 427 dbSNP
rs1368769721 428 dbSNP
rs1033439716 430 dbSNP
rs954284806 437 dbSNP
rs921739339 438 dbSNP
rs980501406 442 dbSNP
rs1234724516 446 dbSNP
rs1382162578 455 dbSNP
rs970911248 461 dbSNP
rs1315450680 462 dbSNP
rs1341433251 466 dbSNP
rs1025563826 470 dbSNP
rs1009858126 471 dbSNP
rs975916879 475 dbSNP
rs965920465 476 dbSNP
rs534340330 479 dbSNP
rs4664 482 dbSNP
rs1261897651 483 dbSNP
rs186042957 484 dbSNP
rs537240795 489 dbSNP
rs1228621452 490 dbSNP
rs376645460 491 dbSNP
rs1352015886 512 dbSNP
rs1427674157 514 dbSNP
rs1010316342 518 dbSNP
rs570274859 519 dbSNP
rs1033161355 523 dbSNP
rs1001260649 526 dbSNP
rs1171653729 528 dbSNP
rs1405361948 531 dbSNP
rs35120053 533 dbSNP
rs1468349151 539 dbSNP
rs905636652 542 dbSNP
rs1045836824 543 dbSNP
rs1381985967 546 dbSNP
rs1293818053 553 dbSNP
rs777402558 555 dbSNP
rs1218801211 558 dbSNP
rs1282305602 560 dbSNP
rs1320792804 564 dbSNP
rs551762850 567 dbSNP
rs1394681466 569 dbSNP
rs558457118 576 dbSNP
rs1014383804 582 dbSNP
rs899815763 583 dbSNP
rs1402056161 587 dbSNP
rs1303945158 590 dbSNP
rs897403976 590 dbSNP
rs755750209 593 dbSNP
rs944123699 599 dbSNP
rs1264974838 601 dbSNP
rs1037284496 602 dbSNP
rs1428936037 606 dbSNP
rs1431480091 606 dbSNP
rs941346297 608 dbSNP
rs890321687 615 dbSNP
rs1287646092 616 dbSNP
rs540159045 618 dbSNP
rs1401063093 634 dbSNP
rs1158595104 636 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions Hela
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1048187. RNA binding protein: AGO2. Condition:Hela_AGO2_CLIP_control ...

- Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al., 2013, Cell.

Article - Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al.
- Cell, 2013
The induction of pluripotency or trans-differentiation of one cell type to another can be accomplished with cell-lineage-specific transcription factors. Here, we report that repression of a single RNA binding polypyrimidine-tract-binding (PTB) protein, which occurs during normal brain development via the action of miR-124, is sufficient to induce trans-differentiation of fibroblasts into functional neurons. Besides its traditional role in regulated splicing, we show that PTB has a previously undocumented function in the regulation of microRNA functions, suppressing or enhancing microRNA targeting by competitive binding on target mRNA or altering local RNA secondary structure. A key event during neuronal induction is the relief of PTB-mediated blockage of microRNA action on multiple components of the REST complex, thereby derepressing a large array of neuronal genes, including miR-124 and multiple neuronal-specific transcription factors, in nonneuronal cells. This converts a negative feedback loop to a positive one to elicit cellular reprogramming to the neuronal lineage.
LinkOut: [PMID: 23313552]
CLIP-seq Support 1 for dataset GSM1048187
Method / RBP HITS-CLIP / AGO2
Cell line / Condition Hela / Hela_AGO2_CLIP_control
Location of target site ENST00000594682.2 | 3UTR | ggauucauacuggagagaaac
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23313552 / GSE42701
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
62 hsa-miR-758-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT085323 MORC3 MORC family CW-type zinc finger 3 2 2
MIRT089441 STAMBP STAM binding protein 2 2
MIRT089456 TET3 tet methylcytosine dioxygenase 3 2 2
MIRT111856 CCND1 cyclin D1 2 2
MIRT184933 ZNF268 zinc finger protein 268 2 2
MIRT215288 CREBRF CREB3 regulatory factor 2 2
MIRT237300 LPP LIM domain containing preferred translocation partner in lipoma 2 2
MIRT238446 MYO10 myosin X 2 4
MIRT273827 RPL41 ribosomal protein L41 2 2
MIRT282703 HOOK1 hook microtubule tethering protein 1 2 2
MIRT347970 ZNF850 zinc finger protein 850 2 2
MIRT371076 KLF3 Kruppel like factor 3 2 2
MIRT464339 USP6NL USP6 N-terminal like 2 2
MIRT470034 PTP4A1 protein tyrosine phosphatase type IVA, member 1 2 2
MIRT477506 ELL2 elongation factor for RNA polymerase II 2 2 2
MIRT482886 CACNA2D3 calcium voltage-gated channel auxiliary subunit alpha2delta 3 2 2
MIRT492606 POLR3E RNA polymerase III subunit E 2 2
MIRT502294 GNG12 G protein subunit gamma 12 2 6
MIRT507600 DCTN4 dynactin subunit 4 2 4
MIRT510728 SON SON DNA binding protein 2 6
MIRT514065 KCNJ6 potassium voltage-gated channel subfamily J member 6 2 8
MIRT519718 ZNF512B zinc finger protein 512B 2 4
MIRT520890 STRN striatin 2 2
MIRT521760 PPIL1 peptidylprolyl isomerase like 1 2 6
MIRT526874 ERCC8 ERCC excision repair 8, CSA ubiquitin ligase complex subunit 2 2
MIRT530232 WSB2 WD repeat and SOCS box containing 2 2 2
MIRT532003 ACTR2 ARP2 actin related protein 2 homolog 2 2
MIRT533371 UBE2D4 ubiquitin conjugating enzyme E2 D4 (putative) 2 4
MIRT547106 PIGW phosphatidylinositol glycan anchor biosynthesis class W 2 2
MIRT548189 FOXA1 forkhead box A1 2 2
MIRT552935 VKORC1L1 vitamin K epoxide reductase complex subunit 1 like 1 2 2
MIRT560085 ZNF195 zinc finger protein 195 2 2
MIRT561726 PPP2CA protein phosphatase 2 catalytic subunit alpha 2 2
MIRT562713 ZNF415 zinc finger protein 415 2 2
MIRT562761 ZNF846 zinc finger protein 846 2 2
MIRT564159 ZNF117 zinc finger protein 117 2 2
MIRT565673 SETD5 SET domain containing 5 2 2
MIRT565718 SESN3 sestrin 3 2 2
MIRT566026 RFX1 regulatory factor X1 2 2
MIRT569048 ZNF655 zinc finger protein 655 2 2
MIRT570367 UBE2V1 ubiquitin conjugating enzyme E2 V1 2 2
MIRT570410 TMEM189-UBE2V1 TMEM189-UBE2V1 readthrough 2 2
MIRT570443 TMEM189 transmembrane protein 189 2 2
MIRT571738 RNF11 ring finger protein 11 2 2
MIRT575042 Tpgs2 tubulin polyglutamylase complex subunit 2 2 4
MIRT614330 ZDHHC22 zinc finger DHHC-type containing 22 2 2
MIRT617629 RAB3IP RAB3A interacting protein 2 2
MIRT621667 UBE4B ubiquitination factor E4B 2 2
MIRT639906 SRGAP2 SLIT-ROBO Rho GTPase activating protein 2 2 2
MIRT651436 XRCC5 X-ray repair cross complementing 5 2 2
MIRT683853 ZNF208 zinc finger protein 208 2 2
MIRT684841 TPGS2 tubulin polyglutamylase complex subunit 2 2 5
MIRT689347 ZNF83 zinc finger protein 83 2 2
MIRT692492 SPIN4 spindlin family member 4 2 2
MIRT695711 OLA1 Obg like ATPase 1 2 2
MIRT698219 TMEM248 transmembrane protein 248 2 2
MIRT711560 FAM20B FAM20B, glycosaminoglycan xylosylkinase 2 2
MIRT712867 TMEM67 transmembrane protein 67 2 2
MIRT722956 TSPAN1 tetraspanin 1 2 2
MIRT723622 SOBP sine oculis binding protein homolog 2 2
MIRT724176 ABCF2 ATP binding cassette subfamily F member 2 2 2
MIRT755363 LMBR1 limb development membrane protein 1 3 1
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-758 Hydroxycamptothecin (HCPT) NULL 97226 Microarray human Tenon's fibroblasts (HTFs) 24681041 2014 down-regulated
miR-758 Diethylstilbestrol approved 448537 Microarray mammosphere-derived epithelial cells (MDEC) 19549897 2009 up-regulated
miR-758 5-Fluorouracil approved 3385 Quantitative real-time PCR human squamous cell carcinoma cell line KYSE410 21743970 2011 up-regulated
miR-758 Reversine NULL 210332 Microarray C2C12 myoblast cells 24513286 2014 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-758 Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-mir-758 Fluorouracil 3385 NSC19893 approved resistant cell line (KYSE)
hsa-mir-758 Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-miR-758-5p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-758-5p Osimertinib 71496458 NSC779217 approved sensitive cell line (HCC827)
hsa-miR-758-5p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-758-5p Paclitaxel 36314 NSC125973 approved sensitive cell line (BAS)
hsa-miR-758-5p Doxorubicin 31703 NSC123127 approved sensitive cell line (BAS)
hsa-miR-758-5p Osimertinib 71496458 NSC779217 approved resistant cell line (H1975)
hsa-miR-758-5p Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (1500 ng/ml)
hsa-miR-758-5p Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)

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