pre-miRNA Information
pre-miRNA hsa-mir-6871   
Genomic Coordinates chr20: 41169023 - 41169078
Description Homo sapiens miR-6871 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-6871-3p
Sequence 35| CAGCACCCUGUGGCUCCCACAG |56
Evidence Experimental
Experiments Meta-analysis
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN16670239 4 COSMIC
COSN1872096 9 COSMIC
COSM1741616 16 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs545076040 1 dbSNP
rs1273348199 2 dbSNP
rs1202373059 5 dbSNP
rs1340707970 7 dbSNP
rs372994756 8 dbSNP
rs869070782 15 dbSNP
rs931272568 16 dbSNP
rs1333765165 18 dbSNP
Putative Targets

Gene Information
Gene Symbol ZNF850
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions Hela
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1048187. RNA binding protein: AGO2. Condition:Hela_AGO2_CLIP_control ...

- Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al., 2013, Cell.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' gacacccuCGG-UGUCCCACGac 5'
                  |||  | |||| |  
Target 5' caaccucuGCCUCCUGGGUUCa- 3'
19 - 40
2
miRNA  3' gacacccucggugucccACGAc 5'
                           |||| 
Target 5' -----------------UGCUa 3'
1 - 5
Article - Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al.
- Cell, 2013
The induction of pluripotency or trans-differentiation of one cell type to another can be accomplished with cell-lineage-specific transcription factors. Here, we report that repression of a single RNA binding polypyrimidine-tract-binding (PTB) protein, which occurs during normal brain development via the action of miR-124, is sufficient to induce trans-differentiation of fibroblasts into functional neurons. Besides its traditional role in regulated splicing, we show that PTB has a previously undocumented function in the regulation of microRNA functions, suppressing or enhancing microRNA targeting by competitive binding on target mRNA or altering local RNA secondary structure. A key event during neuronal induction is the relief of PTB-mediated blockage of microRNA action on multiple components of the REST complex, thereby derepressing a large array of neuronal genes, including miR-124 and multiple neuronal-specific transcription factors, in nonneuronal cells. This converts a negative feedback loop to a positive one to elicit cellular reprogramming to the neuronal lineage.
LinkOut: [PMID: 23313552]
CLIP-seq Support 1 for dataset GSM1048187
Method / RBP HITS-CLIP / AGO2
Cell line / Condition Hela / Hela_AGO2_CLIP_control
Location of target site ENST00000591344.1 | 3UTR | UGCUAUCUUGGCUCACUGCAACCUCUGCCUCCUGGGUUCA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23313552 / GSE42701
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
88 hsa-miR-6871-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT061678 BTG2 BTG anti-proliferation factor 2 2 4
MIRT116181 NUFIP2 NUFIP2, FMR1 interacting protein 2 2 2
MIRT150139 MIDN midnolin 2 2
MIRT197058 NKIRAS2 NFKB inhibitor interacting Ras like 2 2 2
MIRT225108 GOLGA7 golgin A7 2 2
MIRT376288 CALM3 calmodulin 3 2 2
MIRT454810 NEDD9 neural precursor cell expressed, developmentally down-regulated 9 2 2
MIRT464228 VEGFA vascular endothelial growth factor A 2 6
MIRT466961 STAT3 signal transducer and activator of transcription 3 2 2
MIRT468219 SGK1 serum/glucocorticoid regulated kinase 1 2 2
MIRT472460 NASP nuclear autoantigenic sperm protein 2 2
MIRT474203 LEPRE1 prolyl 3-hydroxylase 1 1 1
MIRT475836 HDGF heparin binding growth factor 2 4
MIRT478667 CTC1 CST telomere replication complex component 1 2 14
MIRT478707 CSRNP2 cysteine and serine rich nuclear protein 2 2 2
MIRT478982 COMMD2 COMM domain containing 2 2 2
MIRT479693 CCNT2 cyclin T2 2 6
MIRT488440 ULBP2 UL16 binding protein 2 2 2
MIRT492511 RAET1L retinoic acid early transcript 1L 2 2
MIRT492975 NCS1 neuronal calcium sensor 1 2 2
MIRT494158 COL4A1 collagen type IV alpha 1 chain 2 6
MIRT495934 SLC7A5P2 solute carrier family 7 member 5 pseudogene 2 2 2
MIRT496210 PLEKHG2 pleckstrin homology and RhoGEF domain containing G2 2 2
MIRT496356 PPY pancreatic polypeptide 2 2
MIRT496385 ZC3H6 zinc finger CCCH-type containing 6 2 2
MIRT496463 DCTN5 dynactin subunit 5 2 2
MIRT497642 GLDN gliomedin 2 2
MIRT498496 FRK fyn related Src family tyrosine kinase 2 2
MIRT501928 MCL1 MCL1, BCL2 family apoptosis regulator 2 8
MIRT513286 PDPK1 3-phosphoinositide dependent protein kinase 1 2 2
MIRT514767 RBM4B RNA binding motif protein 4B 2 2
MIRT514916 MDM2 MDM2 proto-oncogene 2 6
MIRT515669 LRRC27 leucine rich repeat containing 27 2 2
MIRT520367 UBE2G2 ubiquitin conjugating enzyme E2 G2 2 2
MIRT523960 DYNLT1 dynein light chain Tctex-type 1 2 4
MIRT526859 KIFC1 kinesin family member C1 2 2
MIRT527673 CASP8 caspase 8 2 2
MIRT527828 TMEM74B transmembrane protein 74B 2 2
MIRT529553 EI24 EI24, autophagy associated transmembrane protein 2 2
MIRT530547 SYNPO synaptopodin 2 2
MIRT531725 TARS threonyl-tRNA synthetase 2 2
MIRT533340 UNC119B unc-119 lipid binding chaperone B 2 2
MIRT533620 TNFRSF13C TNF receptor superfamily member 13C 2 2
MIRT537226 GAN gigaxonin 2 2
MIRT544430 ZNF460 zinc finger protein 460 2 4
MIRT546905 PTP4A1 protein tyrosine phosphatase type IVA, member 1 2 2
MIRT547102 PLAG1 PLAG1 zinc finger 2 2
MIRT547820 ISG20L2 interferon stimulated exonuclease gene 20 like 2 2 2
MIRT548236 FEM1B fem-1 homolog B 2 2
MIRT550034 WWTR1 WW domain containing transcription regulator 1 2 2
MIRT554337 SH3GLB1 SH3 domain containing GRB2 like, endophilin B1 2 4
MIRT565483 SPRTN SprT-like N-terminal domain 2 2
MIRT568200 CBX6 chromobox 6 2 2
MIRT569754 C2orf71 chromosome 2 open reading frame 71 2 2
MIRT571369 ZNF45 zinc finger protein 45 2 2
MIRT609886 CLASP1 cytoplasmic linker associated protein 1 2 4
MIRT640543 C3orf36 chromosome 3 open reading frame 36 2 2
MIRT640885 ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1 2 2
MIRT643494 LRCH3 leucine rich repeats and calponin homology domain containing 3 2 2
MIRT643627 YY2 YY2 transcription factor 2 2
MIRT644384 ZNF286A zinc finger protein 286A 2 2
MIRT646126 SLC26A9 solute carrier family 26 member 9 2 2
MIRT655939 NDUFA4P1 NDUFA4, mitochondrial complex associated pseudogene 1 2 2
MIRT656057 MYLK4 myosin light chain kinase family member 4 2 2
MIRT658767 EIF4EBP2 eukaryotic translation initiation factor 4E binding protein 2 2 2
MIRT661583 EPHX2 epoxide hydrolase 2 2 2
MIRT664285 RNMTL1 mitochondrial rRNA methyltransferase 3 2 2
MIRT689391 ZNF850 zinc finger protein 850 2 2
MIRT694530 TRIM72 tripartite motif containing 72 2 2
MIRT694626 ZFPM1 zinc finger protein, FOG family member 1 2 2
MIRT695133 PRY2 PTPN13-like, Y-linked 2 2 2
MIRT695150 PRY PTPN13-like, Y-linked 2 2
MIRT697468 ZC3H4 zinc finger CCCH-type containing 4 2 2
MIRT701919 MLXIP MLX interacting protein 2 2
MIRT704548 CNBP CCHC-type zinc finger nucleic acid binding protein 2 2
MIRT704791 CDK6 cyclin dependent kinase 6 2 2
MIRT705696 ANKRD13A ankyrin repeat domain 13A 2 2
MIRT707992 OTUD4 OTU deubiquitinase 4 2 2
MIRT708739 FAM71F2 family with sequence similarity 71 member F2 2 2
MIRT713401 FAM179A TOG array regulator of axonemal microtubules 2 2 2
MIRT713846 FAM3D family with sequence similarity 3 member D 2 2
MIRT716998 ARL6IP4 ADP ribosylation factor like GTPase 6 interacting protein 4 2 2
MIRT718511 DIRAS1 DIRAS family GTPase 1 2 2
MIRT718698 BTBD9 BTB domain containing 9 2 2
MIRT719578 TYRO3 TYRO3 protein tyrosine kinase 2 2
MIRT720892 CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 2 2
MIRT722633 C8A complement C8 alpha chain 2 2
MIRT723333 DGAT1 diacylglycerol O-acyltransferase 1 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-6871-3p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-6871-3p Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-6871-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-6871-3p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)

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