pre-miRNA Information | |
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pre-miRNA | hsa-mir-6871 |
Genomic Coordinates | chr20: 41169023 - 41169078 |
Description | Homo sapiens miR-6871 stem-loop |
Comment | None |
RNA Secondary Structure | ![]() |
Mature miRNA Information | ||||||||||||||||||||||||||||
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Mature miRNA | hsa-miR-6871-3p | |||||||||||||||||||||||||||
Sequence | 35| CAGCACCCUGUGGCUCCCACAG |56 | |||||||||||||||||||||||||||
Evidence | Experimental | |||||||||||||||||||||||||||
Experiments | Meta-analysis | DRVs in miRNA |
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SNPs in miRNA |
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Putative Targets |
Gene Information | |
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Gene Symbol | ZNF850 |
Experimental Support 1 for Functional miRNA-Target Interaction | ||||||||||
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miRNA:Target | ---- | |||||||||
Validation Method |
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Conditions | Hela | |||||||||
Location of target site | 3'UTR | |||||||||
Tools used in this research | TargetScan , miRTarCLIP , Piranha | |||||||||
Original Description (Extracted from the article) |
...
HITS-CLIP data was present in GSM1048187. RNA binding protein: AGO2. Condition:Hela_AGO2_CLIP_control
... - Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al., 2013, Cell. |
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miRNA-target interactions (Provided by authors) |
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Article |
- Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al. - Cell, 2013
The induction of pluripotency or trans-differentiation of one cell type to another can be accomplished with cell-lineage-specific transcription factors. Here, we report that repression of a single RNA binding polypyrimidine-tract-binding (PTB) protein, which occurs during normal brain development via the action of miR-124, is sufficient to induce trans-differentiation of fibroblasts into functional neurons. Besides its traditional role in regulated splicing, we show that PTB has a previously undocumented function in the regulation of microRNA functions, suppressing or enhancing microRNA targeting by competitive binding on target mRNA or altering local RNA secondary structure. A key event during neuronal induction is the relief of PTB-mediated blockage of microRNA action on multiple components of the REST complex, thereby derepressing a large array of neuronal genes, including miR-124 and multiple neuronal-specific transcription factors, in nonneuronal cells. This converts a negative feedback loop to a positive one to elicit cellular reprogramming to the neuronal lineage.
LinkOut: [PMID: 23313552]
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CLIP-seq Support 1 for dataset GSM1048187 | |
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Method / RBP | HITS-CLIP / AGO2 |
Cell line / Condition | Hela / Hela_AGO2_CLIP_control |
Location of target site | ENST00000591344.1 | 3UTR | UGCUAUCUUGGCUCACUGCAACCUCUGCCUCCUGGGUUCA |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 23313552 / GSE42701 |
CLIP-seq Viewer | Link |
MiRNA-Target Expression Profile | |||||||
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MiRNA-Target Expression Profile (TCGA) | |||||||
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88 hsa-miR-6871-3p Target Genes:
Functional analysis:
ID![]() |
Target | Description | Validation methods |
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Strong evidence | Less strong evidence | |||||||||||
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MIRT061678 | BTG2 | BTG anti-proliferation factor 2 | ![]() |
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2 | 4 | ||||||
MIRT116181 | NUFIP2 | NUFIP2, FMR1 interacting protein 2 | ![]() |
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2 | 2 | ||||||
MIRT150139 | MIDN | midnolin | ![]() |
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2 | 2 | ||||||
MIRT197058 | NKIRAS2 | NFKB inhibitor interacting Ras like 2 | ![]() |
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2 | 2 | ||||||
MIRT225108 | GOLGA7 | golgin A7 | ![]() |
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2 | 2 | ||||||
MIRT376288 | CALM3 | calmodulin 3 | ![]() |
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2 | 2 | ||||||
MIRT454810 | NEDD9 | neural precursor cell expressed, developmentally down-regulated 9 | ![]() |
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2 | 2 | ||||||
MIRT464228 | VEGFA | vascular endothelial growth factor A | ![]() |
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2 | 6 | ||||||
MIRT466961 | STAT3 | signal transducer and activator of transcription 3 | ![]() |
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2 | 2 | ||||||
MIRT468219 | SGK1 | serum/glucocorticoid regulated kinase 1 | ![]() |
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2 | 2 | ||||||
MIRT472460 | NASP | nuclear autoantigenic sperm protein | ![]() |
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2 | 2 | ||||||
MIRT474203 | LEPRE1 | prolyl 3-hydroxylase 1 | ![]() |
1 | 1 | |||||||
MIRT475836 | HDGF | heparin binding growth factor | ![]() |
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2 | 4 | ||||||
MIRT478667 | CTC1 | CST telomere replication complex component 1 | ![]() |
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2 | 14 | ||||||
MIRT478707 | CSRNP2 | cysteine and serine rich nuclear protein 2 | ![]() |
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2 | 2 | ||||||
MIRT478982 | COMMD2 | COMM domain containing 2 | ![]() |
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2 | 2 | ||||||
MIRT479693 | CCNT2 | cyclin T2 | ![]() |
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2 | 6 | ||||||
MIRT488440 | ULBP2 | UL16 binding protein 2 | ![]() |
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2 | 2 | ||||||
MIRT492511 | RAET1L | retinoic acid early transcript 1L | ![]() |
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2 | 2 | ||||||
MIRT492975 | NCS1 | neuronal calcium sensor 1 | ![]() |
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2 | 2 | ||||||
MIRT494158 | COL4A1 | collagen type IV alpha 1 chain | ![]() |
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2 | 6 | ||||||
MIRT495934 | SLC7A5P2 | solute carrier family 7 member 5 pseudogene 2 | ![]() |
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2 | 2 | ||||||
MIRT496210 | PLEKHG2 | pleckstrin homology and RhoGEF domain containing G2 | ![]() |
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2 | 2 | ||||||
MIRT496356 | PPY | pancreatic polypeptide | ![]() |
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2 | 2 | ||||||
MIRT496385 | ZC3H6 | zinc finger CCCH-type containing 6 | ![]() |
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2 | 2 | ||||||
MIRT496463 | DCTN5 | dynactin subunit 5 | ![]() |
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2 | 2 | ||||||
MIRT497642 | GLDN | gliomedin | ![]() |
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2 | 2 | ||||||
MIRT498496 | FRK | fyn related Src family tyrosine kinase | ![]() |
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2 | 2 | ||||||
MIRT501928 | MCL1 | MCL1, BCL2 family apoptosis regulator | ![]() |
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2 | 8 | ||||||
MIRT513286 | PDPK1 | 3-phosphoinositide dependent protein kinase 1 | ![]() |
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2 | 2 | ||||||
MIRT514767 | RBM4B | RNA binding motif protein 4B | ![]() |
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2 | 2 | ||||||
MIRT514916 | MDM2 | MDM2 proto-oncogene | ![]() |
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2 | 6 | ||||||
MIRT515669 | LRRC27 | leucine rich repeat containing 27 | ![]() |
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2 | 2 | ||||||
MIRT520367 | UBE2G2 | ubiquitin conjugating enzyme E2 G2 | ![]() |
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2 | 2 | ||||||
MIRT523960 | DYNLT1 | dynein light chain Tctex-type 1 | ![]() |
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2 | 4 | ||||||
MIRT526859 | KIFC1 | kinesin family member C1 | ![]() |
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2 | 2 | ||||||
MIRT527673 | CASP8 | caspase 8 | ![]() |
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2 | 2 | ||||||
MIRT527828 | TMEM74B | transmembrane protein 74B | ![]() |
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2 | 2 | ||||||
MIRT529553 | EI24 | EI24, autophagy associated transmembrane protein | ![]() |
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2 | 2 | ||||||
MIRT530547 | SYNPO | synaptopodin | ![]() |
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2 | 2 | ||||||
MIRT531725 | TARS | threonyl-tRNA synthetase | ![]() |
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2 | 2 | ||||||
MIRT533340 | UNC119B | unc-119 lipid binding chaperone B | ![]() |
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2 | 2 | ||||||
MIRT533620 | TNFRSF13C | TNF receptor superfamily member 13C | ![]() |
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2 | 2 | ||||||
MIRT537226 | GAN | gigaxonin | ![]() |
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2 | 2 | ||||||
MIRT544430 | ZNF460 | zinc finger protein 460 | ![]() |
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2 | 4 | ||||||
MIRT546905 | PTP4A1 | protein tyrosine phosphatase type IVA, member 1 | ![]() |
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2 | 2 | ||||||
MIRT547102 | PLAG1 | PLAG1 zinc finger | ![]() |
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2 | 2 | ||||||
MIRT547820 | ISG20L2 | interferon stimulated exonuclease gene 20 like 2 | ![]() |
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2 | 2 | ||||||
MIRT548236 | FEM1B | fem-1 homolog B | ![]() |
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2 | 2 | ||||||
MIRT550034 | WWTR1 | WW domain containing transcription regulator 1 | ![]() |
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2 | 2 | ||||||
MIRT554337 | SH3GLB1 | SH3 domain containing GRB2 like, endophilin B1 | ![]() |
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2 | 4 | ||||||
MIRT565483 | SPRTN | SprT-like N-terminal domain | ![]() |
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2 | 2 | ||||||
MIRT568200 | CBX6 | chromobox 6 | ![]() |
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2 | 2 | ||||||
MIRT569754 | C2orf71 | chromosome 2 open reading frame 71 | ![]() |
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2 | 2 | ||||||
MIRT571369 | ZNF45 | zinc finger protein 45 | ![]() |
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2 | 2 | ||||||
MIRT609886 | CLASP1 | cytoplasmic linker associated protein 1 | ![]() |
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2 | 4 | ||||||
MIRT640543 | C3orf36 | chromosome 3 open reading frame 36 | ![]() |
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2 | 2 | ||||||
MIRT640885 | ENTPD1 | ectonucleoside triphosphate diphosphohydrolase 1 | ![]() |
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2 | 2 | ||||||
MIRT643494 | LRCH3 | leucine rich repeats and calponin homology domain containing 3 | ![]() |
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2 | 2 | ||||||
MIRT643627 | YY2 | YY2 transcription factor | ![]() |
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2 | 2 | ||||||
MIRT644384 | ZNF286A | zinc finger protein 286A | ![]() |
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2 | 2 | ||||||
MIRT646126 | SLC26A9 | solute carrier family 26 member 9 | ![]() |
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2 | 2 | ||||||
MIRT655939 | NDUFA4P1 | NDUFA4, mitochondrial complex associated pseudogene 1 | ![]() |
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2 | 2 | ||||||
MIRT656057 | MYLK4 | myosin light chain kinase family member 4 | ![]() |
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2 | 2 | ||||||
MIRT658767 | EIF4EBP2 | eukaryotic translation initiation factor 4E binding protein 2 | ![]() |
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2 | 2 | ||||||
MIRT661583 | EPHX2 | epoxide hydrolase 2 | ![]() |
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2 | 2 | ||||||
MIRT664285 | RNMTL1 | mitochondrial rRNA methyltransferase 3 | ![]() |
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2 | 2 | ||||||
MIRT689391 | ZNF850 | zinc finger protein 850 | ![]() |
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2 | 2 | ||||||
MIRT694530 | TRIM72 | tripartite motif containing 72 | ![]() |
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2 | 2 | ||||||
MIRT694626 | ZFPM1 | zinc finger protein, FOG family member 1 | ![]() |
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2 | 2 | ||||||
MIRT695133 | PRY2 | PTPN13-like, Y-linked 2 | ![]() |
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2 | 2 | ||||||
MIRT695150 | PRY | PTPN13-like, Y-linked | ![]() |
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2 | 2 | ||||||
MIRT697468 | ZC3H4 | zinc finger CCCH-type containing 4 | ![]() |
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2 | 2 | ||||||
MIRT701919 | MLXIP | MLX interacting protein | ![]() |
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2 | 2 | ||||||
MIRT704548 | CNBP | CCHC-type zinc finger nucleic acid binding protein | ![]() |
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2 | 2 | ||||||
MIRT704791 | CDK6 | cyclin dependent kinase 6 | ![]() |
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2 | 2 | ||||||
MIRT705696 | ANKRD13A | ankyrin repeat domain 13A | ![]() |
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2 | 2 | ||||||
MIRT707992 | OTUD4 | OTU deubiquitinase 4 | ![]() |
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2 | 2 | ||||||
MIRT708739 | FAM71F2 | family with sequence similarity 71 member F2 | ![]() |
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2 | 2 | ||||||
MIRT713401 | FAM179A | TOG array regulator of axonemal microtubules 2 | ![]() |
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2 | 2 | ||||||
MIRT713846 | FAM3D | family with sequence similarity 3 member D | ![]() |
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2 | 2 | ||||||
MIRT716998 | ARL6IP4 | ADP ribosylation factor like GTPase 6 interacting protein 4 | ![]() |
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2 | 2 | ||||||
MIRT718511 | DIRAS1 | DIRAS family GTPase 1 | ![]() |
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2 | 2 | ||||||
MIRT718698 | BTBD9 | BTB domain containing 9 | ![]() |
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2 | 2 | ||||||
MIRT719578 | TYRO3 | TYRO3 protein tyrosine kinase | ![]() |
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2 | 2 | ||||||
MIRT720892 | CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | ![]() |
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2 | 2 | ||||||
MIRT722633 | C8A | complement C8 alpha chain | ![]() |
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2 | 2 | ||||||
MIRT723333 | DGAT1 | diacylglycerol O-acyltransferase 1 | ![]() |
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2 | 2 |
miRNA-Drug Resistance Associations | ||||||||||||||||||||||||||||||||||||||||||||||||||
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