pre-miRNA Information
pre-miRNA hsa-mir-6737   
Genomic Coordinates chr1: 153962351 - 153962420
Description Homo sapiens miR-6737 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-6737-5p
Sequence 6| UUGGGGUGGUCGGCCCUGGAG |26
Evidence Experimental
Experiments Meta-analysis
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs766338599 4 dbSNP
rs765728788 7 dbSNP
rs757341439 9 dbSNP
rs539511149 11 dbSNP
rs764259486 12 dbSNP
rs988937601 21 dbSNP
Putative Targets

Gene Information
Gene Symbol ATXN2   
Synonyms ATX2, SCA2, TNRC13
Description ataxin 2
Transcript NM_002973   
Expression
Putative miRNA Targets on ATXN2
3'UTR of ATXN2
(miRNA target sites are highlighted)
>ATXN2|NM_002973|3'UTR
   1 GGCTGCCCTGGAGGAACCGAAAGGCCAAATTCCCTCCTCCCTTCTACTGCTTCTACCAACTGGAAGCACAGAAAACTAGA
  81 ATTTCATTTATTTTGTTTTTAAAATATATATGTTGATTTCTTGTAACATCCAATAGGAATGCTAACAGTTCACTTGCAGT
 161 GGAAGATACTTGGACCGAGTAGAGGCATTTAGGAACTTGGGGGCTATTCCATAATTCCATATGCTGTTTCAGAGTCCCGC
 241 AGGTACCCCAGCTCTGCTTGCCGAAACTGGAAGTTATTTATTTTTTAATAACCCTTGAAAGTCATGAACACATCAGCTAG
 321 CAAAAGAAGTAACAAGAGTGATTCTTGCTGCTATTACTGCTAAAAAAAAAAAAAAAAAAAAATCAAGACTTGGAACGCCC
 401 TTTTACTAAACTTGACAAAGTTTCAGTAAATTCTTACCGTCAAACTGACGGATTATTATTTATAAATCAAGTTTGATGAG
 481 GTGATCACTGTCTACAGTGGTTCAACTTTTAAGTTAAGGGAAAAACTTTTACTTTGTAGATAATATAAAATAAAAACTTA
 561 AAAAAAATTTAAAAAATAAAAAAAGTTTTAAAAACTGAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' gaGGUCCC--GGC--UGGUGGGGUu 5'
            :||| |  |||  : :|||||| 
Target 5' ttTCAGAGTCCCGCAGGTACCCCAg 3'
227 - 251 135.00 -20.50
2
miRNA  3' gaGGUCCCGGCUGGUGGGGUu 5'
            |: |||  |:|:|::||| 
Target 5' aaCTTGGG--GGCTATTCCAt 3'
194 - 212 111.00 -16.40
3
miRNA  3' gaGGUCCCGG--CUGGUGGGGuu 5'
            :|| | |:  || |:|||:  
Target 5' aaTCAAGACTTGGAACGCCCTtt 3'
381 - 403 101.00 -11.20
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30543130 7 COSMIC
COSN26465583 9 COSMIC
COSN1080549 11 COSMIC
COSN31505690 18 COSMIC
COSN30152089 49 COSMIC
COSN30499534 50 COSMIC
COSN30519869 80 COSMIC
COSN18747062 95 COSMIC
COSN21007807 197 COSMIC
COSN31579511 239 COSMIC
COSN31542503 263 COSMIC
COSN31485168 314 COSMIC
COSN32061887 362 COSMIC
COSN31596800 448 COSMIC
COSN26637046 468 COSMIC
COSN26573003 551 COSMIC
rs11348701 382 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs141600110 1 dbSNP
rs745432430 2 dbSNP
rs778382731 5 dbSNP
rs757254794 6 dbSNP
rs376658853 11 dbSNP
rs375359382 18 dbSNP
rs372412953 19 dbSNP
rs752500419 24 dbSNP
rs767667906 27 dbSNP
rs763583124 28 dbSNP
rs1245974951 36 dbSNP
rs1374158325 39 dbSNP
rs774613038 43 dbSNP
rs759777495 44 dbSNP
rs1393845256 49 dbSNP
rs751743550 51 dbSNP
rs375430831 56 dbSNP
rs763058339 66 dbSNP
rs1368614280 72 dbSNP
rs1167178992 73 dbSNP
rs773868096 79 dbSNP
rs1370468037 83 dbSNP
rs1424752622 85 dbSNP
rs1335605269 88 dbSNP
rs10661 95 dbSNP
rs771301346 96 dbSNP
rs1215606329 100 dbSNP
rs749052489 101 dbSNP
rs770285250 101 dbSNP
rs1423425514 107 dbSNP
rs1252635605 108 dbSNP
rs1184366839 111 dbSNP
rs769796175 112 dbSNP
rs777714896 112 dbSNP
rs762115985 115 dbSNP
rs777032616 120 dbSNP
rs538038973 123 dbSNP
rs1001459090 131 dbSNP
rs963166082 136 dbSNP
rs1422390964 137 dbSNP
rs1164857901 138 dbSNP
rs1354736150 149 dbSNP
rs753800860 149 dbSNP
rs1461544227 153 dbSNP
rs1166461979 158 dbSNP
rs1330400155 159 dbSNP
rs1016121249 170 dbSNP
rs1005628737 175 dbSNP
rs996816394 176 dbSNP
rs763808537 177 dbSNP
rs150319790 182 dbSNP
rs1047057175 198 dbSNP
rs1420700009 203 dbSNP
rs1175846381 204 dbSNP
rs1470000765 205 dbSNP
rs1235282792 206 dbSNP
rs1233832206 209 dbSNP
rs1040373022 210 dbSNP
rs1184169670 219 dbSNP
rs1004981165 221 dbSNP
rs1482507947 222 dbSNP
rs1187638963 225 dbSNP
rs1258906932 232 dbSNP
rs141258927 239 dbSNP
rs555358153 247 dbSNP
rs1416810812 262 dbSNP
rs1049611990 270 dbSNP
rs552206037 271 dbSNP
rs1170771999 275 dbSNP
rs901183152 278 dbSNP
rs1464418350 284 dbSNP
rs931187900 292 dbSNP
rs1040320670 297 dbSNP
rs1416545324 304 dbSNP
rs752377658 305 dbSNP
rs1045001694 316 dbSNP
rs942973776 317 dbSNP
rs1282132437 319 dbSNP
rs542542891 320 dbSNP
rs926093911 321 dbSNP
rs1298049714 327 dbSNP
rs191226454 329 dbSNP
rs917585912 333 dbSNP
rs1373700226 336 dbSNP
rs34618076 337 dbSNP
rs1486835873 339 dbSNP
rs1281097479 348 dbSNP
rs1242025347 353 dbSNP
rs543478848 353 dbSNP
rs945780634 353 dbSNP
rs1186589516 360 dbSNP
rs1421284244 361 dbSNP
rs1172561753 362 dbSNP
rs1452205510 362 dbSNP
rs913010867 362 dbSNP
rs1369852394 369 dbSNP
rs1316190238 377 dbSNP
rs1325956552 377 dbSNP
rs11348701 383 dbSNP
rs1290693029 383 dbSNP
rs1344500573 383 dbSNP
rs1431657381 383 dbSNP
rs1491363617 383 dbSNP
rs574744097 383 dbSNP
rs992497705 383 dbSNP
rs1442554375 384 dbSNP
rs1491163890 384 dbSNP
rs186620842 384 dbSNP
rs1397310833 387 dbSNP
rs1448072258 387 dbSNP
rs907553702 397 dbSNP
rs1157484730 398 dbSNP
rs1192639189 405 dbSNP
rs956365031 412 dbSNP
rs1400643356 416 dbSNP
rs768641797 418 dbSNP
rs1407239434 435 dbSNP
rs979573014 436 dbSNP
rs1161114436 437 dbSNP
rs565866101 438 dbSNP
rs767142167 439 dbSNP
rs979990347 449 dbSNP
rs963321307 450 dbSNP
rs746077387 455 dbSNP
rs1279356180 456 dbSNP
rs117066377 470 dbSNP
rs532249038 471 dbSNP
rs1288286497 480 dbSNP
rs1332090782 484 dbSNP
rs995301657 485 dbSNP
rs898348329 486 dbSNP
rs1469833278 493 dbSNP
rs1469521852 495 dbSNP
rs1179152194 496 dbSNP
rs1365108199 506 dbSNP
rs1232095645 513 dbSNP
rs1470366696 519 dbSNP
rs1178929686 531 dbSNP
rs1415542670 536 dbSNP
rs1461050085 546 dbSNP
rs1182047801 549 dbSNP
rs1165735038 552 dbSNP
rs576986079 560 dbSNP
rs1214931577 562 dbSNP
rs1408436529 567 dbSNP
rs1026115774 568 dbSNP
rs1336751741 568 dbSNP
rs1355377704 568 dbSNP
rs896440401 568 dbSNP
rs947979602 568 dbSNP
rs998284181 571 dbSNP
rs1286061402 577 dbSNP
rs1231856593 581 dbSNP
rs1346696941 584 dbSNP
rs1193747998 585 dbSNP
rs1271826110 585 dbSNP
rs1438225200 585 dbSNP
rs762184183 585 dbSNP
rs901146235 586 dbSNP
rs1206356699 590 dbSNP
rs1255391505 594 dbSNP
rs1474849233 595 dbSNP
rs1018289769 597 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions Hela
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1048187. RNA binding protein: AGO2. Condition:Hela_AGO2_CLIP_control ...

- Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al., 2013, Cell.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' gaggucccGGCU-GGUGGGGUu 5'
                  || | |||||||| 
Target 5' -----auaCCAACCCACCCCAc 3'
1 - 17
Article - Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al.
- Cell, 2013
The induction of pluripotency or trans-differentiation of one cell type to another can be accomplished with cell-lineage-specific transcription factors. Here, we report that repression of a single RNA binding polypyrimidine-tract-binding (PTB) protein, which occurs during normal brain development via the action of miR-124, is sufficient to induce trans-differentiation of fibroblasts into functional neurons. Besides its traditional role in regulated splicing, we show that PTB has a previously undocumented function in the regulation of microRNA functions, suppressing or enhancing microRNA targeting by competitive binding on target mRNA or altering local RNA secondary structure. A key event during neuronal induction is the relief of PTB-mediated blockage of microRNA action on multiple components of the REST complex, thereby derepressing a large array of neuronal genes, including miR-124 and multiple neuronal-specific transcription factors, in nonneuronal cells. This converts a negative feedback loop to a positive one to elicit cellular reprogramming to the neuronal lineage.
LinkOut: [PMID: 23313552]
CLIP-seq Support 1 for dataset GSM1048187
Method / RBP HITS-CLIP / AGO2
Cell line / Condition Hela / Hela_AGO2_CLIP_control
Location of target site ENST00000550104.1 | 3UTR | auaccaacccaccccacauggcccacguaccucagg
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23313552 / GSE42701
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
67 hsa-miR-6737-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT066215 MARCH9 membrane associated ring-CH-type finger 9 2 2
MIRT074413 TNRC6A trinucleotide repeat containing 6A 2 2
MIRT125300 MID1IP1 MID1 interacting protein 1 2 2
MIRT153951 NCOA3 nuclear receptor coactivator 3 2 2
MIRT452776 FAM136A family with sequence similarity 136 member A 2 2
MIRT452977 CABP4 calcium binding protein 4 2 2
MIRT454128 FOXRED2 FAD dependent oxidoreductase domain containing 2 2 2
MIRT455242 DDX39B DExD-box helicase 39B 2 10
MIRT459007 UQCRH ubiquinol-cytochrome c reductase hinge protein 2 2
MIRT459463 MUC17 mucin 17, cell surface associated 2 4
MIRT460871 UBE2S ubiquitin conjugating enzyme E2 S 2 2
MIRT461264 COX10 COX10, heme A:farnesyltransferase cytochrome c oxidase assembly factor 2 2
MIRT464540 UBTF upstream binding transcription factor, RNA polymerase I 2 2
MIRT465268 TRIM28 tripartite motif containing 28 2 2
MIRT465871 TMEM43 transmembrane protein 43 2 4
MIRT466228 TMED10 transmembrane p24 trafficking protein 10 2 2
MIRT468417 SETD1B SET domain containing 1B 2 2
MIRT468684 SEC22C SEC22 homolog C, vesicle trafficking protein 2 4
MIRT473399 MDM4 MDM4, p53 regulator 2 2
MIRT473517 MAX MYC associated factor X 2 2
MIRT474511 KLHDC8A kelch domain containing 8A 2 2
MIRT475801 HDGF heparin binding growth factor 2 2
MIRT479493 CDH6 cadherin 6 2 2
MIRT480770 BMP2 bone morphogenetic protein 2 2 2
MIRT481418 ASB6 ankyrin repeat and SOCS box containing 6 2 2
MIRT482966 CSTF2 cleavage stimulation factor subunit 2 2 2
MIRT483380 SPATA6 spermatogenesis associated 6 2 4
MIRT483677 CYP11A1 cytochrome P450 family 11 subfamily A member 1 2 2
MIRT484328 EPN1 epsin 1 2 4
MIRT484963 UCK1 uridine-cytidine kinase 1 2 2
MIRT485908 PGPEP1 pyroglutamyl-peptidase I 2 4
MIRT488149 PRRC2B proline rich coiled-coil 2B 2 4
MIRT488943 CYP2W1 cytochrome P450 family 2 subfamily W member 1 2 6
MIRT491835 ZBTB7A zinc finger and BTB domain containing 7A 2 4
MIRT493026 NAA50 N(alpha)-acetyltransferase 50, NatE catalytic subunit 2 2
MIRT499374 PLCG2 phospholipase C gamma 2 2 11
MIRT499723 USH1G USH1 protein network component sans 2 4
MIRT500349 ZNF385A zinc finger protein 385A 2 2
MIRT509574 HIST2H2AB histone cluster 2 H2A family member b 2 4
MIRT512794 GLRX glutaredoxin 2 2
MIRT513291 SETBP1 SET binding protein 1 2 2
MIRT515697 ZNF321P zinc finger protein 321, pseudogene 2 2
MIRT518255 LEAP2 liver enriched antimicrobial peptide 2 2 2
MIRT522026 PAQR3 progestin and adipoQ receptor family member 3 2 4
MIRT523169 HIST3H3 histone cluster 3 H3 2 2
MIRT524036 DNAJC8 DnaJ heat shock protein family (Hsp40) member C8 2 2
MIRT533476 TRIM71 tripartite motif containing 71 2 2
MIRT541488 ADM adrenomedullin 2 2
MIRT553987 SRPR SRP receptor alpha subunit 2 2
MIRT571445 YKT6 YKT6 v-SNARE homolog 2 2
MIRT574889 Plcg2 phospholipase C, gamma 2 2 7
MIRT607544 GLI2 GLI family zinc finger 2 2 2
MIRT607688 MAPK10 mitogen-activated protein kinase 10 2 2
MIRT610072 CRLF1 cytokine receptor like factor 1 2 2
MIRT610573 CACUL1 CDK2 associated cullin domain 1 2 2
MIRT614041 THBS2 thrombospondin 2 2 2
MIRT626318 LRTOMT leucine rich transmembrane and O-methyltransferase domain containing 2 2
MIRT634005 RIF1 replication timing regulatory factor 1 2 2
MIRT639619 FGF19 fibroblast growth factor 19 2 2
MIRT647343 RPH3AL rabphilin 3A like (without C2 domains) 2 2
MIRT689704 ATXN2 ataxin 2 2 2
MIRT691170 APOL6 apolipoprotein L6 2 2
MIRT693165 NPR1 natriuretic peptide receptor 1 2 2
MIRT711727 NUPL2 nucleoporin like 2 2 2
MIRT711806 ELN elastin 2 2
MIRT721546 FXN frataxin 2 2
MIRT722979 GDE1 glycerophosphodiester phosphodiesterase 1 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-6737 Ceritinib 57379345 NSC776422 approved sensitive High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-mir-6737 Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)
hsa-miR-6737-5p Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-6737-5p Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-miR-6737-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-6737-5p Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)
hsa-miR-6737-5p Paclitaxel 36314 NSC125973 approved resistant cell line (A2780)
hsa-miR-6737-5p Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)
hsa-miR-6737-5p Docetaxel+Cisplatin+5-Fluorouracil resistant tissue (hypopharyngeal squamous cell carcinoma)

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