pre-miRNA Information
pre-miRNA hsa-mir-3622b   
Genomic Coordinates chr8: 27701673 - 27701767
Description Homo sapiens miR-3622b stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-3622b-3p
Sequence 58| UCACCUGAGCUCCCGUGCCUG |78
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1232922758 2 dbSNP
rs530939348 5 dbSNP
rs1439657384 10 dbSNP
rs1157333896 12 dbSNP
rs66683138 14 dbSNP
rs1044808718 15 dbSNP
rs946438979 19 dbSNP
rs551845360 21 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol MMP17   
Synonyms MMP-17, MT4-MMP, MT4MMP, MTMMP4
Description matrix metallopeptidase 17
Transcript NM_016155   
Expression
Putative miRNA Targets on MMP17
3'UTR of MMP17
(miRNA target sites are highlighted)
>MMP17|NM_016155|3'UTR
   1 CACACAGCGCGAGCCCATGAGAGGACAGAGGCGGTGGGACAGCCTGGCCACAGAGGGCAAGGACTGTGCCGGAGTCCCTG
  81 GGGGAGGTGCTGGCGCGGGATGAGGACGGGCCACCCTGGCACCGGAAGGCCAGCAGAGGGCACTGCCCGCCAGGGCTGGG
 161 CAGGCTCAGGTGGCAAGGACGGAGCTGTCCCCTAGTGAGGGACTGTGTTGACTGACGAGCCGAGGGGTGGCCGCTCCAGA
 241 AGGGTGCCCAGTCAGGCCGCACCGCCGCCAGCCTCCTCCGGCCCTGGAGGGAGCATCTCGGGCTGGGGGCCCACCCCTCT
 321 CTGTGCCGGCGCCACCAACCCCACCCACACTGCTGCCTGGTGCTCCCGCCGGCCCACAGGGCCTCCGTCCCCAGGTCCCC
 401 AGTGGGGCAGCCCTCCCCACAGACGAGCCCCCCACATGGTGCCGCGGCACGTCCCCCCTGTGACGCGTTCCAGACCAACA
 481 TGACCTCTCCCTGCTTT
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' guCCGUGCCC--UCGAGUCCACu 5'
            ||| :|||  :||||||||| 
Target 5' agGGC-TGGGCAGGCTCAGGTGg 3'
152 - 173 164.00 -28.30
2
miRNA  3' guCCGUG----CCCUC---GAGUCC-ACu 5'
            ||| |    |||||   |||:|| || 
Target 5' ccGGCCCTGGAGGGAGCATCTCGGGCTGg 3'
278 - 306 113.00 -21.00
3
miRNA  3' guccgUGCCCUCG----AGUCCacu 5'
               | ||| ||    |||||   
Target 5' tccagAAGGGTGCCCAGTCAGGccg 3'
235 - 259 110.00 -13.42
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30742373 2 COSMIC
COSN24490460 10 COSMIC
COSN30745496 12 COSMIC
COSN31538539 62 COSMIC
COSN4727980 84 COSMIC
COSN15662863 259 COSMIC
COSN24774459 332 COSMIC
COSN20077714 425 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1407484848 1 dbSNP
rs753123184 2 dbSNP
rs1161160480 6 dbSNP
rs1415352225 7 dbSNP
rs1203138449 8 dbSNP
rs1460691703 10 dbSNP
rs531146846 11 dbSNP
rs1051708948 12 dbSNP
rs1486466869 15 dbSNP
rs1263039175 18 dbSNP
rs750326609 24 dbSNP
rs1198093388 27 dbSNP
rs1234730035 28 dbSNP
rs1353245235 29 dbSNP
rs200157527 33 dbSNP
rs571678418 34 dbSNP
rs995465558 46 dbSNP
rs1374766923 48 dbSNP
rs904238056 56 dbSNP
rs1429684393 62 dbSNP
rs1266619140 63 dbSNP
rs1350269942 65 dbSNP
rs999915606 71 dbSNP
rs539143522 72 dbSNP
rs561631467 73 dbSNP
rs1429228490 75 dbSNP
rs530374840 79 dbSNP
rs368843547 82 dbSNP
rs1035527639 87 dbSNP
rs1188894827 88 dbSNP
rs1254011765 90 dbSNP
rs1423931440 91 dbSNP
rs958823857 94 dbSNP
rs1215982594 95 dbSNP
rs1218670776 96 dbSNP
rs991345759 96 dbSNP
rs980473434 97 dbSNP
rs914267829 98 dbSNP
rs968458536 108 dbSNP
rs977028661 109 dbSNP
rs1324000635 111 dbSNP
rs924307120 125 dbSNP
rs1325480099 135 dbSNP
rs10751704 145 dbSNP
rs7136508 147 dbSNP
rs766236427 149 dbSNP
rs565936588 150 dbSNP
rs1467443240 154 dbSNP
rs942827076 163 dbSNP
rs1251921892 166 dbSNP
rs1196032515 168 dbSNP
rs1039873287 172 dbSNP
rs1249109294 174 dbSNP
rs911759069 181 dbSNP
rs898557001 182 dbSNP
rs943308886 191 dbSNP
rs995602790 192 dbSNP
rs1369993922 199 dbSNP
rs532351410 206 dbSNP
rs1329099357 207 dbSNP
rs1309780453 208 dbSNP
rs1392173445 217 dbSNP
rs1047077711 218 dbSNP
rs887148357 220 dbSNP
rs1002786286 222 dbSNP
rs1219018073 223 dbSNP
rs552267937 226 dbSNP
rs1183075564 229 dbSNP
rs1267518814 232 dbSNP
rs1420471524 234 dbSNP
rs1248040025 244 dbSNP
rs1483126500 252 dbSNP
rs1485715753 257 dbSNP
rs117299843 259 dbSNP
rs1208620805 260 dbSNP
rs1347142336 263 dbSNP
rs891958700 264 dbSNP
rs1249478430 265 dbSNP
rs1014416698 267 dbSNP
rs958653027 268 dbSNP
rs113512489 281 dbSNP
rs906078171 296 dbSNP
rs1375415217 300 dbSNP
rs1433399601 300 dbSNP
rs554512851 301 dbSNP
rs1361638982 302 dbSNP
rs1180660902 305 dbSNP
rs1403806412 307 dbSNP
rs1021472384 310 dbSNP
rs968427490 311 dbSNP
rs1185208119 313 dbSNP
rs374447846 314 dbSNP
rs1476819538 318 dbSNP
rs1284893817 319 dbSNP
rs977163005 326 dbSNP
rs1206636690 327 dbSNP
rs924277386 328 dbSNP
rs568234055 329 dbSNP
rs533875432 331 dbSNP
rs780812264 332 dbSNP
rs1449484405 334 dbSNP
rs1295173137 335 dbSNP
rs912764661 339 dbSNP
rs942982019 343 dbSNP
rs1340342468 347 dbSNP
rs1319563013 349 dbSNP
rs554083097 355 dbSNP
rs1286321498 360 dbSNP
rs1383242426 361 dbSNP
rs1354734763 365 dbSNP
rs975956647 367 dbSNP
rs1226236399 368 dbSNP
rs115918518 369 dbSNP
rs1342472229 370 dbSNP
rs931384041 371 dbSNP
rs371911316 372 dbSNP
rs1437150553 373 dbSNP
rs1474614497 382 dbSNP
rs573568372 387 dbSNP
rs887200884 388 dbSNP
rs1188242776 395 dbSNP
rs911743173 402 dbSNP
rs1445273704 403 dbSNP
rs1471713826 406 dbSNP
rs1214141573 419 dbSNP
rs1335702202 423 dbSNP
rs1275310404 425 dbSNP
rs1231457027 426 dbSNP
rs1355743339 427 dbSNP
rs1270905318 430 dbSNP
rs545783397 433 dbSNP
rs938643082 434 dbSNP
rs1320275711 435 dbSNP
rs1057151109 444 dbSNP
rs894355506 445 dbSNP
rs1390973296 446 dbSNP
rs1404186472 447 dbSNP
rs1431880264 451 dbSNP
rs1419600645 452 dbSNP
rs1169216621 454 dbSNP
rs1474368507 455 dbSNP
rs1372482806 456 dbSNP
rs974712106 458 dbSNP
rs1166784904 459 dbSNP
rs868634645 465 dbSNP
rs556306169 466 dbSNP
rs1415516972 467 dbSNP
rs79040389 468 dbSNP
rs1339250856 478 dbSNP
rs1447710293 479 dbSNP
rs904402277 485 dbSNP
rs1298801915 486 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions Hela
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1048187. RNA binding protein: AGO2. Condition:Hela_AGO2_CLIP_control ...

- Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al., 2013, Cell.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' gucCGUGCCCUCGAGUCC-ACu 5'
             |||:|  :| ||||| || 
Target 5' --aGCAUGUUGG-UCAGGCUGg 3'
1 - 19
Article - Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al.
- Cell, 2013
The induction of pluripotency or trans-differentiation of one cell type to another can be accomplished with cell-lineage-specific transcription factors. Here, we report that repression of a single RNA binding polypyrimidine-tract-binding (PTB) protein, which occurs during normal brain development via the action of miR-124, is sufficient to induce trans-differentiation of fibroblasts into functional neurons. Besides its traditional role in regulated splicing, we show that PTB has a previously undocumented function in the regulation of microRNA functions, suppressing or enhancing microRNA targeting by competitive binding on target mRNA or altering local RNA secondary structure. A key event during neuronal induction is the relief of PTB-mediated blockage of microRNA action on multiple components of the REST complex, thereby derepressing a large array of neuronal genes, including miR-124 and multiple neuronal-specific transcription factors, in nonneuronal cells. This converts a negative feedback loop to a positive one to elicit cellular reprogramming to the neuronal lineage.
LinkOut: [PMID: 23313552]
CLIP-seq Support 1 for dataset GSM1048187
Method / RBP HITS-CLIP / AGO2
Cell line / Condition Hela / Hela_AGO2_CLIP_control
Location of target site ENST00000535291.1 | 3UTR | AGCAUGUUGGUCAGGCUGGUCUCGAACUCCUGACCUCA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23313552 / GSE42701
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
THCA -0.263 0.28 -0.143 0.38 7 Click to see details
THCA -0.263 0.28 -0.143 0.38 7 Click to see details
THCA -0.263 0.28 -0.143 0.38 7 Click to see details
THCA -0.263 0.28 -0.143 0.38 7 Click to see details
THCA -0.263 0.28 -0.143 0.38 7 Click to see details
THCA -0.263 0.28 -0.143 0.38 7 Click to see details
102 hsa-miR-3622b-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT076713 NUFIP2 NUFIP2, FMR1 interacting protein 2 2 2
MIRT080212 PRKACB protein kinase cAMP-activated catalytic subunit beta 2 2
MIRT081398 GTPBP3 GTP binding protein 3, mitochondrial 2 2
MIRT107158 ZBTB43 zinc finger and BTB domain containing 43 2 2
MIRT254071 BACH1 BTB domain and CNC homolog 1 2 2
MIRT409790 FOXO3 forkhead box O3 2 2
MIRT448679 MAPK9 mitogen-activated protein kinase 9 2 2
MIRT450206 ABHD15 abhydrolase domain containing 15 2 2
MIRT486621 PDK3 pyruvate dehydrogenase kinase 3 2 2
MIRT489267 TTLL1 tubulin tyrosine ligase like 1 2 2
MIRT493117 MKNK2 MAP kinase interacting serine/threonine kinase 2 2 4
MIRT494570 BAK1 BCL2 antagonist/killer 1 2 2
MIRT497395 RALY RALY heterogeneous nuclear ribonucleoprotein 2 2
MIRT504900 CCDC86 coiled-coil domain containing 86 2 2
MIRT505192 USP46 ubiquitin specific peptidase 46 2 4
MIRT506522 MSANTD4 Myb/SANT DNA binding domain containing 4 with coiled-coils 2 6
MIRT508162 ABCC5 ATP binding cassette subfamily C member 5 2 8
MIRT508545 PARVG parvin gamma 2 4
MIRT509850 BIRC5 baculoviral IAP repeat containing 5 2 6
MIRT510088 PPWD1 peptidylprolyl isomerase domain and WD repeat containing 1 2 8
MIRT512094 CRK CRK proto-oncogene, adaptor protein 2 4
MIRT515381 RPL7 ribosomal protein L7 2 2
MIRT519176 SCO1 SCO1, cytochrome c oxidase assembly protein 2 2
MIRT519964 ZCCHC8 zinc finger CCHC-type containing 8 2 2
MIRT522292 NKAP NFKB activating protein 2 2
MIRT523160 HMGB2 high mobility group box 2 2 4
MIRT525314 FANCA Fanconi anemia complementation group A 2 2
MIRT528194 PLEKHM2 pleckstrin homology and RUN domain containing M2 2 2
MIRT532885 ZNF451 zinc finger protein 451 2 2
MIRT538209 CYR61 cysteine rich angiogenic inducer 61 2 2
MIRT539497 ACTN4 actinin alpha 4 2 2
MIRT554600 RRAGC Ras related GTP binding C 2 2
MIRT562444 DCTN6 dynactin subunit 6 2 2
MIRT562748 AOC3 amine oxidase, copper containing 3 2 2
MIRT565798 SEC14L5 SEC14 like lipid binding 5 2 2
MIRT565838 SCML2 Scm polycomb group protein like 2 2 2
MIRT566072 RCC2 regulator of chromosome condensation 2 2 2
MIRT566104 RBPJ recombination signal binding protein for immunoglobulin kappa J region 2 2
MIRT572407 MRPS14 mitochondrial ribosomal protein S14 2 2
MIRT576198 Vsig2 V-set and immunoglobulin domain containing 2 2 2
MIRT576313 Acbd7 acyl-Coenzyme A binding domain containing 7 2 2
MIRT576651 Mill2 MHC I like leukocyte 2 1 1
MIRT576859 Socs6 suppressor of cytokine signaling 6 2 2
MIRT606819 BICD2 BICD cargo adaptor 2 2 2
MIRT610738 NUDT16 nudix hydrolase 16 2 4
MIRT614798 RORA RAR related orphan receptor A 2 2
MIRT619006 NTMT1 N-terminal Xaa-Pro-Lys N-methyltransferase 1 2 2
MIRT619420 NOS1AP nitric oxide synthase 1 adaptor protein 2 2
MIRT620405 MYO1H myosin IH 2 2
MIRT624869 ABHD13 abhydrolase domain containing 13 2 2
MIRT633527 ZFP30 ZFP30 zinc finger protein 2 2
MIRT633927 DNAH9 dynein axonemal heavy chain 9 2 2
MIRT636611 CLIC5 chloride intracellular channel 5 2 2
MIRT640616 MIOX myo-inositol oxygenase 2 2
MIRT642605 C14orf180 chromosome 14 open reading frame 180 2 2
MIRT644624 SRSF2 serine and arginine rich splicing factor 2 2 2
MIRT655113 PHLDA3 pleckstrin homology like domain family A member 3 2 2
MIRT658976 DNAJB5 DnaJ heat shock protein family (Hsp40) member B5 2 4
MIRT661495 CHMP1B charged multivesicular body protein 1B 2 2
MIRT662996 TMEM59 transmembrane protein 59 2 2
MIRT663075 SFR1 SWI5 dependent homologous recombination repair protein 1 2 2
MIRT665405 WEE1 WEE1 G2 checkpoint kinase 2 2
MIRT666106 SSR1 signal sequence receptor subunit 1 2 2
MIRT669562 ALDOA aldolase, fructose-bisphosphate A 2 2
MIRT670070 ZNF783 zinc finger family member 783 2 2
MIRT671192 ZNF891 zinc finger protein 891 2 2
MIRT675361 KLHL26 kelch like family member 26 2 2
MIRT678857 LINC00598 long intergenic non-protein coding RNA 598 2 2
MIRT679443 C19orf52 translocase of inner mitochondrial membrane 29 2 2
MIRT684163 ALDH1B1 aldehyde dehydrogenase 1 family member B1 2 2
MIRT684543 ZNF460 zinc finger protein 460 2 2
MIRT684674 SLC2A11 solute carrier family 2 member 11 2 2
MIRT684971 MINOS1 mitochondrial inner membrane organizing system 1 2 2
MIRT686006 NEK4 NIMA related kinase 4 2 2
MIRT687758 KIAA1328 KIAA1328 2 2
MIRT688961 ATXN3 ataxin 3 2 2
MIRT689409 UQCR11 ubiquinol-cytochrome c reductase, complex III subunit XI 2 2
MIRT690001 MMP17 matrix metallopeptidase 17 2 2
MIRT690165 ELP3 elongator acetyltransferase complex subunit 3 2 2
MIRT690202 C5orf45 MRN complex interacting protein 2 2
MIRT690477 ZNF33A zinc finger protein 33A 2 2
MIRT690566 MICA MHC class I polypeptide-related sequence A 2 2
MIRT692160 C10orf111 chromosome 10 open reading frame 111 2 2
MIRT693430 PLGLB2 plasminogen-like B2 2 2
MIRT693547 ZNF708 zinc finger protein 708 2 2
MIRT693697 PLGLB1 plasminogen-like B1 2 2
MIRT695006 HSPA6 heat shock protein family A (Hsp70) member 6 2 2
MIRT698525 TFRC transferrin receptor 2 2
MIRT699574 SIKE1 suppressor of IKBKE 1 2 2
MIRT703446 FYTTD1 forty-two-three domain containing 1 2 2
MIRT704397 CTSS cathepsin S 2 2
MIRT704485 CPT1A carnitine palmitoyltransferase 1A 2 2
MIRT709822 STPG1 sperm tail PG-rich repeat containing 1 2 2
MIRT710859 COQ7 coenzyme Q7, hydroxylase 2 2
MIRT711893 INSIG2 insulin induced gene 2 2 2
MIRT713796 CPLX2 complexin 2 2 2
MIRT718800 C1GALT1C1 C1GALT1 specific chaperone 1 2 2
MIRT719501 SEC24B SEC24 homolog B, COPII coat complex component 2 2
MIRT719722 PDE6B phosphodiesterase 6B 2 2
MIRT722204 URM1 ubiquitin related modifier 1 2 2
MIRT723523 CLPTM1L CLPTM1 like 2 2
MIRT725471 GRAP2 GRB2-related adaptor protein 2 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-3622b-3p Platinum 23939 sensitive tissue
hsa-miR-3622b-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-3622b-3p Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (1500 ng/ml)
hsa-miR-3622b-3p Paclitaxel/Docetaxel/Vinorelbine/Doxorubicin/Etoposide resistant cell line (Bads-200)

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