pre-miRNA Information
pre-miRNA hsa-mir-4666a   
Genomic Coordinates chr1: 228462074 - 228462152
Description Homo sapiens miR-4666a stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4666a-5p
Sequence 10| AUACAUGUCAGAUUGUAUGCC |30
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1288210208 3 dbSNP
rs1333314792 5 dbSNP
rs562096649 7 dbSNP
rs1324809033 10 dbSNP
rs1027635037 13 dbSNP
rs1351630778 15 dbSNP
rs1034879562 18 dbSNP
rs1383267208 21 dbSNP
Putative Targets

Gene Information
Gene Symbol C21orf58   
Synonyms -
Description chromosome 21 open reading frame 58
Transcript NM_058180   
Expression
Putative miRNA Targets on C21orf58
3'UTR of C21orf58
(miRNA target sites are highlighted)
>C21orf58|NM_058180|3'UTR
   1 GTGTGAGTCACAGAGACCCTGGCCGGGGCACCCTCCACCCCCAGGCTTCCTCAGGGCTGTGGGCTGTGGCGGGACTATGG
  81 AAGGGAGCAGGGAGAGACCCTGCCACCACCCGGAGTGGCTACGCGAGTGTGGACTGCAGGCTCCTCCTGGGGAAGCTGGG
 161 CAGGCTCGCTTTCTGGTCACGGGGCCATTCCAGGGGGCATCCCTTGCTCCGGGTCCCCTGCAGTGAGGGGCCTGTGAACC
 241 CCACCAGGGCAACAGCCCCTCCCAGGGACCCCTCCTTTCCTGTAGGGCGGCGCCGGCCCACCTGGGAGCCTCAGATCCCC
 321 CTCTTCCATCACGGAGGTAAAGTTGAGGCCGTGGACGCCACCAGCCTGATGAAATAAAGATTTCATCCAGAAAGAGTTTA
 401 AGAAAATCTCAGCTCAGGAGCCAGAACAGAAAAGATCAATAGCTTTAGCCACATGGAAGTGTGAACATCCTGATGGGGAA
 481 AATACCACAAAGTCTAATTTAATAACTAGGGACACCTGTGTGCCACAGCTGTGGCACAGACTCCCACTAAAGAAGTAGGG
 561 GTGCATGGCTCATGCCTGTAATCCCAGCACTTTAAGAGGCTGAGGCAGGAGGATCACTTGAGCTCAGGAATTCGAGACCA
 641 GCCTGGGTCACATAGCAAGACCCCGTCTCTACAAAAAATAAATTTAAAAAACTAGCCAGGTGTGGTGATATGCGCCTGTT
 721 ATCTCAGCAGCTCTGGGGGCTGAGGTGGGAGGATTGCTTGAGCCCAGGAGTTAGAAGCTGCAGTGAGCTCTGATGGAACC
 801 ACTGCACTATAGCCTGGACCACAGAGCAGGCCCCTGTCTCAAAAAATAAAATAAAAAAGTGAAAGAAGCAAAAAAAAAAA
 881 AAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' ccGUAUGUUAGACUGUACAUa 5'
            |||: : ||  :| |||| 
Target 5' tgCATG-GCTCATGCCTGTAa 3'
562 - 581 102.00 -7.40
2
miRNA  3' ccgUAUGUUA--GA---CUGU--ACAUa 5'
             || :|||  ||   ||||  |||: 
Target 5' ctaATTTAATAACTAGGGACACCTGTGt 3'
494 - 521 100.00 -5.60
3
miRNA  3' ccGUAUGUUAGACUGUACaua 5'
            || :::   |||:|||   
Target 5' gcCAGGTGTGGTGATATGcgc 3'
695 - 715 95.00 -7.12
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30510472 22 COSMIC
COSN28868819 39 COSMIC
COSN1257843 69 COSMIC
COSN8012508 75 COSMIC
COSN26564467 98 COSMIC
COSN19483898 470 COSMIC
COSN20117098 521 COSMIC
COSN24049113 859 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs773503440 1 dbSNP
rs1446619062 7 dbSNP
rs1355484406 8 dbSNP
rs771723398 15 dbSNP
rs1417709158 17 dbSNP
rs1359677696 21 dbSNP
rs1159547583 23 dbSNP
rs371284029 24 dbSNP
rs540148246 25 dbSNP
rs1180242674 28 dbSNP
rs768697079 29 dbSNP
rs1258268276 31 dbSNP
rs1190703967 32 dbSNP
rs1487563147 36 dbSNP
rs1048621519 38 dbSNP
rs865961391 39 dbSNP
rs757640474 42 dbSNP
rs1216952997 47 dbSNP
rs994169154 55 dbSNP
rs1464328914 57 dbSNP
rs1188141861 69 dbSNP
rs892409760 70 dbSNP
rs1174487581 71 dbSNP
rs1040226903 75 dbSNP
rs1008771718 88 dbSNP
rs1169785260 91 dbSNP
rs888962339 99 dbSNP
rs1049798301 101 dbSNP
rs112580445 111 dbSNP
rs554157967 112 dbSNP
rs1341429495 115 dbSNP
rs1429621311 116 dbSNP
rs1172557545 117 dbSNP
rs1366748339 121 dbSNP
rs927380444 122 dbSNP
rs1044254496 123 dbSNP
rs535508261 124 dbSNP
rs1440492833 125 dbSNP
rs914529566 132 dbSNP
rs1038806707 135 dbSNP
rs568525856 140 dbSNP
rs1446161682 148 dbSNP
rs1208378018 161 dbSNP
rs1246342610 167 dbSNP
rs114795895 168 dbSNP
rs530612884 171 dbSNP
rs3747007 174 dbSNP
rs551219687 175 dbSNP
rs533281423 176 dbSNP
rs1174782786 178 dbSNP
rs559419014 180 dbSNP
rs541008804 181 dbSNP
rs1017272717 183 dbSNP
rs1318143082 195 dbSNP
rs1390459690 198 dbSNP
rs767795510 210 dbSNP
rs968228757 211 dbSNP
rs952880137 215 dbSNP
rs1027218725 229 dbSNP
rs528925294 236 dbSNP
rs1349688389 240 dbSNP
rs1206523435 241 dbSNP
rs3747006 252 dbSNP
rs543546185 270 dbSNP
rs1311920749 278 dbSNP
rs1412770225 279 dbSNP
rs1266794235 280 dbSNP
rs772813904 282 dbSNP
rs375064539 285 dbSNP
rs372060109 288 dbSNP
rs149602754 289 dbSNP
rs1057446815 291 dbSNP
rs1018842211 292 dbSNP
rs558400929 294 dbSNP
rs1457488887 295 dbSNP
rs546150709 296 dbSNP
rs567375370 297 dbSNP
rs1387933559 298 dbSNP
rs1324138731 300 dbSNP
rs375800033 309 dbSNP
rs1050699920 311 dbSNP
rs371322944 313 dbSNP
rs1335156176 314 dbSNP
rs572676692 332 dbSNP
rs1368453141 333 dbSNP
rs1163307690 337 dbSNP
rs554202030 350 dbSNP
rs1038370138 351 dbSNP
rs914394228 355 dbSNP
rs190655683 356 dbSNP
rs1483038949 357 dbSNP
rs908551594 364 dbSNP
rs976160702 365 dbSNP
rs943040897 384 dbSNP
rs1163638798 391 dbSNP
rs1366287420 392 dbSNP
rs1056617846 396 dbSNP
rs984488071 399 dbSNP
rs1197105362 405 dbSNP
rs776608644 417 dbSNP
rs1480668711 420 dbSNP
rs952911170 424 dbSNP
rs568406662 425 dbSNP
rs939617173 437 dbSNP
rs1309736516 440 dbSNP
rs1027124077 450 dbSNP
rs556189321 452 dbSNP
rs537957106 456 dbSNP
rs1310298324 461 dbSNP
rs926796940 472 dbSNP
rs1247221409 474 dbSNP
rs796349615 475 dbSNP
rs1336809644 477 dbSNP
rs967819486 489 dbSNP
rs746400019 492 dbSNP
rs961935027 505 dbSNP
rs1293731320 507 dbSNP
rs915006645 516 dbSNP
rs34014831 521 dbSNP
rs111446685 522 dbSNP
rs11399715 522 dbSNP
rs796126812 522 dbSNP
rs112418156 523 dbSNP
rs72562362 523 dbSNP
rs1331112124 524 dbSNP
rs1035913678 527 dbSNP
rs1425225427 530 dbSNP
rs1187757651 534 dbSNP
rs1389050920 536 dbSNP
rs1003321420 538 dbSNP
rs987899738 544 dbSNP
rs956323084 546 dbSNP
rs1371153644 553 dbSNP
rs1390113835 555 dbSNP
rs758569668 563 dbSNP
rs1300906500 568 dbSNP
rs1381042820 570 dbSNP
rs1398027618 575 dbSNP
rs569475471 582 dbSNP
rs1018641279 583 dbSNP
rs550952174 584 dbSNP
rs1299898151 589 dbSNP
rs953448625 592 dbSNP
rs1343578764 593 dbSNP
rs138422828 598 dbSNP
rs1028808243 601 dbSNP
rs1471812428 606 dbSNP
rs146323299 607 dbSNP
rs565957610 616 dbSNP
rs547425355 617 dbSNP
rs185168883 632 dbSNP
rs1016934540 633 dbSNP
rs180951536 636 dbSNP
rs1390225188 644 dbSNP
rs1419235701 645 dbSNP
rs1004271325 652 dbSNP
rs1432572574 659 dbSNP
rs8129883 663 dbSNP
rs866409909 664 dbSNP
rs1337652459 667 dbSNP
rs1388249429 682 dbSNP
rs1433159563 684 dbSNP
rs11089057 685 dbSNP
rs1469796145 689 dbSNP
rs1362720472 691 dbSNP
rs905479771 699 dbSNP
rs1273728552 713 dbSNP
rs1207936447 714 dbSNP
rs934477124 715 dbSNP
rs1224573446 734 dbSNP
rs901790781 735 dbSNP
rs1045226084 737 dbSNP
rs1210187266 738 dbSNP
rs1248131521 743 dbSNP
rs946842711 755 dbSNP
rs915417393 764 dbSNP
rs943054133 766 dbSNP
rs116209545 769 dbSNP
rs1427105966 774 dbSNP
rs987867089 777 dbSNP
rs189267812 779 dbSNP
rs984393036 780 dbSNP
rs1409446675 802 dbSNP
rs1455885034 803 dbSNP
rs1322746954 805 dbSNP
rs377177348 808 dbSNP
rs1345869535 812 dbSNP
rs1240067477 825 dbSNP
rs911547837 828 dbSNP
rs1291847396 834 dbSNP
rs1370449361 835 dbSNP
rs869170014 839 dbSNP
rs11443408 845 dbSNP
rs201855232 845 dbSNP
rs397801377 845 dbSNP
rs869180095 845 dbSNP
rs199725472 846 dbSNP
rs1229887750 850 dbSNP
rs1284434260 851 dbSNP
rs1320604124 854 dbSNP
rs1218815080 867 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions Hela
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1048187. RNA binding protein: AGO2. Condition:Hela_AGO2_CLIP_control ...

- Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al., 2013, Cell.

Article - Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al.
- Cell, 2013
The induction of pluripotency or trans-differentiation of one cell type to another can be accomplished with cell-lineage-specific transcription factors. Here, we report that repression of a single RNA binding polypyrimidine-tract-binding (PTB) protein, which occurs during normal brain development via the action of miR-124, is sufficient to induce trans-differentiation of fibroblasts into functional neurons. Besides its traditional role in regulated splicing, we show that PTB has a previously undocumented function in the regulation of microRNA functions, suppressing or enhancing microRNA targeting by competitive binding on target mRNA or altering local RNA secondary structure. A key event during neuronal induction is the relief of PTB-mediated blockage of microRNA action on multiple components of the REST complex, thereby derepressing a large array of neuronal genes, including miR-124 and multiple neuronal-specific transcription factors, in nonneuronal cells. This converts a negative feedback loop to a positive one to elicit cellular reprogramming to the neuronal lineage.
LinkOut: [PMID: 23313552]
CLIP-seq Support 1 for dataset GSM1048187
Method / RBP HITS-CLIP / AGO2
Cell line / Condition Hela / Hela_AGO2_CLIP_control
Location of target site ENST00000397683.1 | 3UTR | AUUAGCCAGGUGUGGUGGCACACAC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23313552 / GSE42701
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
83 hsa-miR-4666a-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT057266 FAM35A family with sequence similarity 35 member A 2 2
MIRT059969 PATL1 PAT1 homolog 1, processing body mRNA decay factor 2 6
MIRT079031 TNRC6C trinucleotide repeat containing 6C 2 2
MIRT079631 DNAJB4 DnaJ heat shock protein family (Hsp40) member B4 2 2
MIRT086974 LANCL1 LanC like 1 2 2
MIRT091804 GOLGA4 golgin A4 2 2
MIRT229501 EIF1AX eukaryotic translation initiation factor 1A, X-linked 2 4
MIRT255972 WDR17 WD repeat domain 17 2 2
MIRT262975 ADO 2-aminoethanethiol dioxygenase 2 2
MIRT264774 PAFAH1B2 platelet activating factor acetylhydrolase 1b catalytic subunit 2 2 2
MIRT334169 CCND1 cyclin D1 2 6
MIRT345868 SRSF2 serine and arginine rich splicing factor 2 2 2
MIRT452477 DDX4 DEAD-box helicase 4 2 2
MIRT455764 TSPAN6 tetraspanin 6 2 4
MIRT461627 DCAF15 DDB1 and CUL4 associated factor 15 2 4
MIRT465169 TRPV2 transient receptor potential cation channel subfamily V member 2 2 4
MIRT468950 RPS14 ribosomal protein S14 2 6
MIRT483236 C2orf72 chromosome 2 open reading frame 72 2 8
MIRT498544 TMEM30B transmembrane protein 30B 2 2
MIRT500633 TXNIP thioredoxin interacting protein 2 4
MIRT504113 GPR158 G protein-coupled receptor 158 2 2
MIRT504428 ZNF85 zinc finger protein 85 2 6
MIRT505036 ZNF451 zinc finger protein 451 2 2
MIRT506526 MRPL17 mitochondrial ribosomal protein L17 2 6
MIRT508773 GSG1 germ cell associated 1 2 2
MIRT517297 ELF4 E74 like ETS transcription factor 4 2 6
MIRT519353 OBFC1 STN1, CST complex subunit 2 4
MIRT523891 ENPP6 ectonucleotide pyrophosphatase/phosphodiesterase 6 2 6
MIRT527509 ZNF134 zinc finger protein 134 2 2
MIRT531218 IFNGR2 interferon gamma receptor 2 2 2
MIRT535957 MOGAT1 monoacylglycerol O-acyltransferase 1 2 2
MIRT537229 GALNT7 polypeptide N-acetylgalactosaminyltransferase 7 2 4
MIRT537337 FKBP5 FK506 binding protein 5 2 2
MIRT539125 ARHGEF17 Rho guanine nucleotide exchange factor 17 2 2
MIRT539910 ISPD isoprenoid synthase domain containing 2 2
MIRT541527 MGAT4C MGAT4 family member C 2 2
MIRT546119 USP25 ubiquitin specific peptidase 25 2 2
MIRT548846 CERCAM cerebral endothelial cell adhesion molecule 2 2
MIRT549892 LINC00955 long intergenic non-protein coding RNA 955 2 2
MIRT549898 ADH4 alcohol dehydrogenase 4 (class II), pi polypeptide 2 2
MIRT550763 ENOX2 ecto-NOX disulfide-thiol exchanger 2 2 4
MIRT553200 UBE2A ubiquitin conjugating enzyme E2 A 2 2
MIRT553970 SRSF10 serine and arginine rich splicing factor 10 2 2
MIRT554092 SMU1 DNA replication regulator and spliceosomal factor 2 2
MIRT555208 PROX1 prospero homeobox 1 2 4
MIRT555834 PAX5 paired box 5 2 4
MIRT556865 JAZF1 JAZF zinc finger 1 2 2
MIRT558594 CREBL2 cAMP responsive element binding protein like 2 2 2
MIRT559690 AGO2 argonaute 2, RISC catalytic component 2 4
MIRT563312 ORC4 origin recognition complex subunit 4 2 2
MIRT563585 FAM229B family with sequence similarity 229 member B 2 2
MIRT563853 ALYREF Aly/REF export factor 2 4
MIRT565146 TUBB2A tubulin beta 2A class IIa 2 2
MIRT565769 SEPHS1 selenophosphate synthetase 1 2 2
MIRT568317 BACH1 BTB domain and CNC homolog 1 2 2
MIRT575387 Unc5b unc-5 netrin receptor B 2 4
MIRT607728 BDH1 3-hydroxybutyrate dehydrogenase 1 2 8
MIRT612691 PLXNA4 plexin A4 2 4
MIRT615916 GDPD1 glycerophosphodiester phosphodiesterase domain containing 1 2 2
MIRT629792 P2RY1 purinergic receptor P2Y1 2 2
MIRT632119 FKBP9 FK506 binding protein 9 2 2
MIRT645554 ZDHHC15 zinc finger DHHC-type containing 15 2 4
MIRT651479 WWC3 WWC family member 3 2 2
MIRT654138 RPH3A rabphilin 3A 2 6
MIRT655191 PHAX phosphorylated adaptor for RNA export 2 2
MIRT665543 UNC5B unc-5 netrin receptor B 2 5
MIRT668057 GRIK3 glutamate ionotropic receptor kainate type subunit 3 2 2
MIRT678978 CERS4 ceramide synthase 4 2 4
MIRT679124 RBM3 RNA binding motif (RNP1, RRM) protein 3 2 2
MIRT686776 AZF1 azoospermia factor 1 2 2
MIRT687144 PTPN12 protein tyrosine phosphatase, non-receptor type 12 2 2
MIRT691453 C21orf58 chromosome 21 open reading frame 58 2 2
MIRT691469 FAM98B family with sequence similarity 98 member B 2 2
MIRT697031 UHRF1BP1 UHRF1 binding protein 1 2 2
MIRT698401 TM9SF3 transmembrane 9 superfamily member 3 2 2
MIRT702056 RNMT RNA guanine-7 methyltransferase 2 2
MIRT705903 ADAM9 ADAM metallopeptidase domain 9 2 2
MIRT707491 MMADHC methylmalonic aciduria and homocystinuria, cblD type 2 2
MIRT708080 KLHL23 kelch like family member 23 2 2
MIRT709738 TRIM27 tripartite motif containing 27 2 2
MIRT710056 RWDD2A RWD domain containing 2A 2 2
MIRT710226 KCNK1 potassium two pore domain channel subfamily K member 1 2 2
MIRT712043 STYK1 serine/threonine/tyrosine kinase 1 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-4666a Doxorubicin 31703 NSC123127 approved sensitive High Triple-Negative Breast Cancer cell line (MDA-MB-231, MDA-MB-468)

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