pre-miRNA Information
pre-miRNA hsa-mir-1303   
Genomic Coordinates chr5: 154685776 - 154685861
Synonyms MIRN1303, hsa-mir-1303, MIR1303
Description Homo sapiens miR-1303 stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-1303
Sequence 52| UUUAGAGACGGGGUCUUGCUCU |73
Evidence Experimental
Experiments Illumina
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 4 5 + 154685830 23291724, 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs370437195 6 dbSNP
rs1195001383 7 dbSNP
rs546614687 8 dbSNP
rs762579883 9 dbSNP
rs766041486 10 dbSNP
rs751079975 12 dbSNP
rs888516744 13 dbSNP
rs566454487 14 dbSNP
rs766973220 15 dbSNP
rs1474274822 17 dbSNP
rs753222192 18 dbSNP
rs1230907999 19 dbSNP
rs756552638 22 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol LARS   
Synonyms HSPC192, ILFS1, LARS1, LEURS, LEUS, LFIS, LRS, PIG44, RNTLS, hr025Cl
Description leucyl-tRNA synthetase
Transcript NM_020117   
Expression
Putative miRNA Targets on LARS
3'UTR of LARS
(miRNA target sites are highlighted)
>LARS|NM_020117|3'UTR
   1 ACTCATGCACATTGGAGATTTATCCTGGTTTCTTAGGAATACTACTACTCTGATTGTGTCTACTGATTGGCTATCAGAAC
  81 CTTAGGCTGGACCTAAATAGATTGATTTCATTTCTAACCATCCAATTCTGCATGTATTCATAATTCTATCAAGTCATCTT
 161 TGATTCCTGGACCTAATAAATTTTTTTTCCCTTTCTTTGGGTGTCCAAGAGAAATGGTTTTTGCCAAACTCTTTTTAAAA
 241 AACAAATTGTTGCTATTTCCTAGAAGTTTCTGGTTTTTAAGATGAACATAAAAGTGTCAGTATGCTTCTTTTATGAGGTG
 321 TACTTTATACTTTGATGAAGGCTAAGGTGTACCTAACAGCTTTTTATAGTATATTCATTTATGGAGTTAGCTGTATTTTT
 401 TTTTAAAAAAGAAAAGTAGTAAATTAGCAGCTTTTTTTTTTAAATGAAGAGAACTTCATGATGATTTAAAAGAACTAATG
 481 AGAATATTTTGACTTGACTTCAATTACTAAGTATTTTGTATAAAGAACAAATAGGTCCTGCATTTTATAAGACTTTTTAA
 561 AGCTTTAATTATTCAACTAAGAACCAATAATGGCTTCTTCAAGGCTAATATCAATAGTTTATAAGCAGTATATTTCACCT
 641 ACACTAAATATGGGCATTTTAAAAGAAGATTCCCCCCTTCCCCCCCAGAAATCTGCATTTACTAAATTTGTCTTAAGTCC
 721 AATTGTGTTTAAAGGTCATGCTGGTCGGGTGTGGTGGCTCACACCTATAATCCCAGCACTTTGGGAGGCCAAGGTGGGCA
 801 GTCACCTGAGGTCAGGAGTTTGAGACCAGCCTGACCAACATGGTGAAACCCCGTCTCTACTAAAAATACAAAAATTAGCT
 881 TGGCATGGTGGCGGGTACCTGTAATCCCAGCTGCTTGGGAGTGTGAGGCAGGAGAATCGCTTGAACCTGGGAGACCGAGG
 961 TTGCAGTGAGCTGAAACCGTGCCATTGCACTCCAGCTTAGGCAACAAGAGTGAAACTCTGTCTCAATCAATCCATCAATC
1041 AATCAATAAAATAGAGGTCATGCTGACTATTACAGATTTAAAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' ucUCGUUCUGGGGCAGAGAUuu 5'
            :|::| ||||||||||||  
Target 5' atGGTGAAACCCCGTCTCTAct 3'
840 - 861 160.00 -21.80
2
miRNA  3' ucUCGUUCUGGGGCAGAGAUUu 5'
            ||   ||:::| |:||||| 
Target 5' atAGATTGATTTCATTTCTAAc 3'
97 - 118 140.00 -9.60
3
miRNA  3' ucUCGUUCUGGGG-CAGAGAUUu 5'
            || ||| ::|: ||:|:||| 
Target 5' ctAG-AAGTTTCTGGTTTTTAAg 3'
260 - 281 127.00 -10.40
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
1207166 147 ClinVar
COSN30155519 4 COSMIC
COSN30128081 8 COSMIC
COSN26982206 63 COSMIC
COSN30533687 76 COSMIC
COSN30190603 100 COSMIC
COSN31596605 108 COSMIC
COSN30481274 109 COSMIC
COSN30525882 122 COSMIC
COSN30106354 148 COSMIC
COSN30155510 155 COSMIC
COSN31599776 197 COSMIC
COSN8204796 272 COSMIC
COSN7879184 404 COSMIC
COSN20102007 431 COSMIC
COSN20102006 767 COSMIC
COSN29291183 892 COSMIC
COSN31962485 939 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1023558176 2 dbSNP
rs531865973 5 dbSNP
rs1338448468 18 dbSNP
rs762347420 25 dbSNP
rs1288993646 27 dbSNP
rs777071439 28 dbSNP
rs1426850253 34 dbSNP
rs768857847 41 dbSNP
rs761065138 43 dbSNP
rs1378598535 46 dbSNP
rs775050925 47 dbSNP
rs1489043762 48 dbSNP
rs1210000371 49 dbSNP
rs563000111 50 dbSNP
rs745446896 51 dbSNP
rs896337197 56 dbSNP
rs1423783928 63 dbSNP
rs1052291100 81 dbSNP
rs1044791209 84 dbSNP
rs935055736 92 dbSNP
rs903639360 104 dbSNP
rs1382356052 119 dbSNP
rs1158147015 120 dbSNP
rs1363267481 125 dbSNP
rs1043409919 130 dbSNP
rs931670465 131 dbSNP
rs935233403 138 dbSNP
rs923878505 142 dbSNP
rs148479269 147 dbSNP
rs529331221 156 dbSNP
rs1322630113 158 dbSNP
rs1238816133 168 dbSNP
rs878983328 169 dbSNP
rs1284802536 174 dbSNP
rs752747618 178 dbSNP
rs946505503 180 dbSNP
rs1218392814 188 dbSNP
rs1263271316 189 dbSNP
rs976376289 193 dbSNP
rs1165875474 195 dbSNP
rs1485093931 198 dbSNP
rs563786309 199 dbSNP
rs1258190495 208 dbSNP
rs1424135154 211 dbSNP
rs944848287 223 dbSNP
rs1378295831 225 dbSNP
rs1421748614 229 dbSNP
rs1159537062 231 dbSNP
rs974816897 235 dbSNP
rs1192542338 237 dbSNP
rs908033767 238 dbSNP
rs1305065729 241 dbSNP
rs966533255 243 dbSNP
rs983615948 246 dbSNP
rs544711340 252 dbSNP
rs983453898 255 dbSNP
rs952124723 278 dbSNP
rs1307494953 282 dbSNP
rs185108838 288 dbSNP
rs950947603 290 dbSNP
rs373058785 291 dbSNP
rs1027696627 296 dbSNP
rs1191697793 300 dbSNP
rs1311035621 305 dbSNP
rs1467839304 306 dbSNP
rs1027889941 307 dbSNP
rs1257640211 308 dbSNP
rs1483524728 316 dbSNP
rs1178013675 317 dbSNP
rs1253364867 318 dbSNP
rs1215390664 319 dbSNP
rs980474806 322 dbSNP
rs1441326926 327 dbSNP
rs776262874 328 dbSNP
rs1394735551 330 dbSNP
rs1431458487 331 dbSNP
rs1178293879 341 dbSNP
rs1359863063 347 dbSNP
rs995063742 356 dbSNP
rs182725018 367 dbSNP
rs1023556191 371 dbSNP
rs1309480753 373 dbSNP
rs1366498638 378 dbSNP
rs1023948721 403 dbSNP
rs12188941 404 dbSNP
rs1197869185 405 dbSNP
rs1312324603 405 dbSNP
rs192275064 405 dbSNP
rs1458892563 406 dbSNP
rs1370958783 411 dbSNP
rs1245956797 419 dbSNP
rs187320736 424 dbSNP
rs1030831296 425 dbSNP
rs1326968040 428 dbSNP
rs1425948929 433 dbSNP
rs1388944563 441 dbSNP
rs1169085613 442 dbSNP
rs35861595 442 dbSNP
rs397757858 442 dbSNP
rs1325625362 448 dbSNP
rs1348544078 451 dbSNP
rs1294939138 453 dbSNP
rs1367610668 458 dbSNP
rs564354454 474 dbSNP
rs116288959 481 dbSNP
rs1167557396 482 dbSNP
rs70998054 485 dbSNP
rs1276168731 501 dbSNP
rs1470848542 503 dbSNP
rs1319882439 507 dbSNP
rs1219211874 510 dbSNP
rs1462506737 513 dbSNP
rs903565857 516 dbSNP
rs1043504248 518 dbSNP
rs1223979922 519 dbSNP
rs996217658 521 dbSNP
rs900185661 522 dbSNP
rs1487981448 524 dbSNP
rs1253613767 528 dbSNP
rs371857458 532 dbSNP
rs1435873344 538 dbSNP
rs1478417669 550 dbSNP
rs946621420 556 dbSNP
rs556255628 558 dbSNP
rs1412001202 559 dbSNP
rs1407439499 572 dbSNP
rs1166418493 577 dbSNP
rs921751429 579 dbSNP
rs1196041334 585 dbSNP
rs933533086 590 dbSNP
rs1039311999 605 dbSNP
rs944804375 611 dbSNP
rs1400524601 615 dbSNP
rs536342228 618 dbSNP
rs983403300 625 dbSNP
rs766657420 627 dbSNP
rs944965942 628 dbSNP
rs908171301 632 dbSNP
rs1290801488 636 dbSNP
rs1304891013 666 dbSNP
rs1353231085 669 dbSNP
rs1214773804 670 dbSNP
rs573884156 675 dbSNP
rs920613243 676 dbSNP
rs1236264970 678 dbSNP
rs973585369 678 dbSNP
rs970750567 679 dbSNP
rs535955773 680 dbSNP
rs1023132639 685 dbSNP
rs960474519 686 dbSNP
rs1284541910 687 dbSNP
rs1450187301 687 dbSNP
rs572413685 687 dbSNP
rs1375965077 697 dbSNP
rs1238169768 714 dbSNP
rs1311745010 715 dbSNP
rs181773158 720 dbSNP
rs999297000 721 dbSNP
rs17104247 722 dbSNP
rs534088039 746 dbSNP
rs1211519259 747 dbSNP
rs773405601 748 dbSNP
rs917244221 758 dbSNP
rs56864252 763 dbSNP
rs147125041 764 dbSNP
rs139105220 765 dbSNP
rs139958604 767 dbSNP
rs16742 769 dbSNP
rs1171460514 772 dbSNP
rs58132111 783 dbSNP
rs1399485535 788 dbSNP
rs960611300 794 dbSNP
rs1030926236 798 dbSNP
rs1337376414 802 dbSNP
rs890307622 805 dbSNP
rs1444343509 812 dbSNP
rs551633976 813 dbSNP
rs1232855726 814 dbSNP
rs1273144347 815 dbSNP
rs1347286081 818 dbSNP
rs1220257522 821 dbSNP
rs144287258 822 dbSNP
rs138954063 834 dbSNP
rs189158554 835 dbSNP
rs995923939 843 dbSNP
rs1239223282 850 dbSNP
rs900280846 852 dbSNP
rs1040034653 853 dbSNP
rs1008980445 869 dbSNP
rs1177018919 888 dbSNP
rs1202725000 892 dbSNP
rs886656355 893 dbSNP
rs948981234 899 dbSNP
rs916178380 901 dbSNP
rs549505368 905 dbSNP
rs529325162 906 dbSNP
rs1240285986 923 dbSNP
rs560547413 926 dbSNP
rs1332842170 930 dbSNP
rs1291674988 931 dbSNP
rs993108444 936 dbSNP
rs1047977606 938 dbSNP
rs930787277 939 dbSNP
rs1376167849 946 dbSNP
rs960462616 947 dbSNP
rs1336049797 948 dbSNP
rs920743988 949 dbSNP
rs1044986121 953 dbSNP
rs1264865111 956 dbSNP
rs138184888 957 dbSNP
rs917360524 959 dbSNP
rs58569901 960 dbSNP
rs1458678761 964 dbSNP
rs1337985564 978 dbSNP
rs956033508 979 dbSNP
rs781245864 984 dbSNP
rs923826309 989 dbSNP
rs978022273 990 dbSNP
rs778236182 1005 dbSNP
rs1238673167 1007 dbSNP
rs1393180151 1008 dbSNP
rs200960270 1008 dbSNP
rs1280010610 1009 dbSNP
rs199851408 1009 dbSNP
rs3836839 1010 dbSNP
rs753478800 1010 dbSNP
rs1297624537 1013 dbSNP
rs1338609441 1016 dbSNP
rs1402385321 1022 dbSNP
rs1011009955 1024 dbSNP
rs1352877176 1030 dbSNP
rs1022118250 1031 dbSNP
rs1267654680 1032 dbSNP
rs185520886 1033 dbSNP
rs1017909462 1035 dbSNP
rs1284664157 1037 dbSNP
rs1008834095 1038 dbSNP
rs1195667733 1040 dbSNP
rs890246625 1042 dbSNP
rs1422980069 1045 dbSNP
rs1047561473 1046 dbSNP
rs1370021755 1048 dbSNP
rs1425530540 1055 dbSNP
rs1331677223 1056 dbSNP
rs1358641250 1067 dbSNP
rs1421599125 1071 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions Hela
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1048187. RNA binding protein: AGO2. Condition:Hela_AGO2_CLIP_control ...

- Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al., 2013, Cell.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' ucUCGUUCUGGGGCAGAgauuu 5'
            :|::| |||||||||     
Target 5' auGGUGAAACCCCGUCU----- 3'
24 - 40
Article - Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al.
- Cell, 2013
The induction of pluripotency or trans-differentiation of one cell type to another can be accomplished with cell-lineage-specific transcription factors. Here, we report that repression of a single RNA binding polypyrimidine-tract-binding (PTB) protein, which occurs during normal brain development via the action of miR-124, is sufficient to induce trans-differentiation of fibroblasts into functional neurons. Besides its traditional role in regulated splicing, we show that PTB has a previously undocumented function in the regulation of microRNA functions, suppressing or enhancing microRNA targeting by competitive binding on target mRNA or altering local RNA secondary structure. A key event during neuronal induction is the relief of PTB-mediated blockage of microRNA action on multiple components of the REST complex, thereby derepressing a large array of neuronal genes, including miR-124 and multiple neuronal-specific transcription factors, in nonneuronal cells. This converts a negative feedback loop to a positive one to elicit cellular reprogramming to the neuronal lineage.
LinkOut: [PMID: 23313552]
CLIP-seq Support 1 for dataset GSM1048187
Method / RBP HITS-CLIP / AGO2
Cell line / Condition Hela / Hela_AGO2_CLIP_control
Location of target site ENST00000394434.2 | 3UTR | AGUUUGAGACCAGCCUGACCAACAUGGUGAAACCCCGUCU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23313552 / GSE42701
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE32688 Pancreatic cancer 0.577 2.7e-4 0.673 1.2e-5 32 Click to see details
GSE28544 Breast cancer 0.559 2.3e-3 0.583 1.4e-3 24 Click to see details
GSE28260 Renal cortex and medulla 0.648 8.3e-3 0.577 1.9e-2 13 Click to see details
GSE38226 Liver fibrosis -0.356 5.7e-2 -0.347 6.2e-2 21 Click to see details
GSE42095 Differentiated embryonic stem cells 0.281 9.7e-2 0.397 3.0e-2 23 Click to see details
GSE26953 Aortic valvular endothelial cells -0.137 2.6e-1 -0.186 1.9e-1 24 Click to see details
GSE38974 Chronic obstructive pulmonary disease 0.014 4.7e-1 -0.194 1.8e-1 25 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
186 hsa-miR-1303 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT035871 SOAT1 sterol O-acyltransferase 1 1 1
MIRT035872 FHOD3 formin homology 2 domain containing 3 1 1
MIRT035873 RPL7A ribosomal protein L7a 1 1
MIRT035874 NCAPD2 non-SMC condensin I complex subunit D2 1 1
MIRT035875 RPS8 ribosomal protein S8 1 1
MIRT035876 AHNAK AHNAK nucleoprotein 1 1
MIRT035877 ACTB actin beta 1 1
MIRT035878 DEF8 differentially expressed in FDCP 8 homolog 1 1
MIRT035879 MET MET proto-oncogene, receptor tyrosine kinase 1 1
MIRT035880 MED13 mediator complex subunit 13 1 1
MIRT035881 FAT3 FAT atypical cadherin 3 1 1
MIRT035882 HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 1 1
MIRT035883 RPS16 ribosomal protein S16 1 1
MIRT035884 CDK6 cyclin dependent kinase 6 1 1
MIRT035885 GEMIN5 gem nuclear organelle associated protein 5 1 1
MIRT035886 PITRM1 pitrilysin metallopeptidase 1 1 1
MIRT035887 PRRC2A proline rich coiled-coil 2A 1 1
MIRT035888 KIAA0226 RUN and cysteine rich domain containing beclin 1 interacting protein 1 1
MIRT035889 MLLT6 MLLT6, PHD finger containing 1 1
MIRT035890 EIF3I eukaryotic translation initiation factor 3 subunit I 1 1
MIRT035891 FASN fatty acid synthase 1 1
MIRT035892 LEPREL4 prolyl 3-hydroxylase family member 4 (non-enzymatic) 1 1
MIRT035893 HSCB HscB mitochondrial iron-sulfur cluster cochaperone 1 1
MIRT035894 PSME4 proteasome activator subunit 4 1 1
MIRT035895 FRS2 fibroblast growth factor receptor substrate 2 1 1
MIRT035896 ZNF264 zinc finger protein 264 1 1
MIRT035897 HYLS1 HYLS1, centriolar and ciliogenesis associated 1 1
MIRT035898 USP54 ubiquitin specific peptidase 54 1 1
MIRT035899 L1TD1 LINE1 type transposase domain containing 1 1 1
MIRT035900 OR51E2 olfactory receptor family 51 subfamily E member 2 1 1
MIRT053762 CLDN18 claudin 18 3 1
MIRT060730 RPS3 ribosomal protein S3 2 2
MIRT083986 RAB22A RAB22A, member RAS oncogene family 2 2
MIRT098550 TBPL1 TATA-box binding protein like 1 2 6
MIRT134983 TWF1 twinfilin actin binding protein 1 2 4
MIRT136956 FNDC3A fibronectin type III domain containing 3A 2 2
MIRT222065 PURB purine rich element binding protein B 2 2
MIRT239574 UBN2 ubinuclein 2 2 4
MIRT261820 BUB3 BUB3, mitotic checkpoint protein 2 2
MIRT264698 C11ORF57 chromosome 11 open reading frame 57 2 4
MIRT308476 GXYLT2 glucoside xylosyltransferase 2 2 2
MIRT377481 NDUFB5 NADH:ubiquinone oxidoreductase subunit B5 2 2
MIRT442304 NEU3 neuraminidase 3 2 2
MIRT446083 SLC30A10 solute carrier family 30 member 10 2 2
MIRT449606 PRPF4 pre-mRNA processing factor 4 2 2
MIRT453767 NUCB1 nucleobindin 1 2 10
MIRT455603 SRSF3 serine and arginine rich splicing factor 3 2 2
MIRT455913 KIF2C kinesin family member 2C 2 2
MIRT460091 ZYG11B zyg-11 family member B, cell cycle regulator 2 4
MIRT460866 UBE2S ubiquitin conjugating enzyme E2 S 2 2
MIRT461339 NUP133 nucleoporin 133 2 2
MIRT463769 YOD1 YOD1 deubiquitinase 2 2
MIRT466368 THAP1 THAP domain containing 1 2 4
MIRT467168 SPTY2D1 SPT2 chromatin protein domain containing 1 2 2
MIRT468703 SDHD succinate dehydrogenase complex subunit D 2 2
MIRT469122 RNF126 ring finger protein 126 2 2
MIRT472426 NCBP2 nuclear cap binding protein subunit 2 2 4
MIRT479420 CDKN1B cyclin dependent kinase inhibitor 1B 2 8
MIRT484260 FAM177A1 family with sequence similarity 177 member A1 2 2
MIRT485468 IL6ST interleukin 6 signal transducer 2 10
MIRT490237 H2AFZ H2A histone family member Z 2 6
MIRT491002 ATF7IP activating transcription factor 7 interacting protein 2 2
MIRT492127 SUMO2 small ubiquitin-like modifier 2 2 2
MIRT499169 RBPJL recombination signal binding protein for immunoglobulin kappa J region like 2 2
MIRT499825 PCSK9 proprotein convertase subtilisin/kexin type 9 2 8
MIRT501794 NRAS NRAS proto-oncogene, GTPase 2 2
MIRT503441 GINS4 GINS complex subunit 4 2 4
MIRT503688 MAVS mitochondrial antiviral signaling protein 2 5
MIRT506926 IGDCC4 immunoglobulin superfamily DCC subclass member 4 2 6
MIRT511430 HOXA10 homeobox A10 2 6
MIRT512415 LAYN layilin 2 4
MIRT513791 NIPAL3 NIPA like domain containing 3 2 4
MIRT516163 NTMT1 N-terminal Xaa-Pro-Lys N-methyltransferase 1 2 4
MIRT516513 PARK2 parkin RBR E3 ubiquitin protein ligase 2 2
MIRT516915 HINFP histone H4 transcription factor 2 2
MIRT517102 NDUFV3 NADH:ubiquinone oxidoreductase subunit V3 2 2
MIRT517350 NLRP9 NLR family pyrin domain containing 9 2 2
MIRT518019 ABHD15 abhydrolase domain containing 15 2 2
MIRT520945 SRSF10 serine and arginine rich splicing factor 10 2 2
MIRT525250 RNF213 ring finger protein 213 2 2
MIRT530634 PPIC peptidylprolyl isomerase C 2 4
MIRT530671 CHRNB1 cholinergic receptor nicotinic beta 1 subunit 2 4
MIRT531563 ILDR1 immunoglobulin like domain containing receptor 1 2 2
MIRT538205 CYR61 cysteine rich angiogenic inducer 61 2 2
MIRT538419 COLEC10 collectin subfamily member 10 2 2
MIRT541964 ZNF485 zinc finger protein 485 2 2
MIRT543088 KNSTRN kinetochore localized astrin/SPAG5 binding protein 2 2
MIRT543257 ZNF662 zinc finger protein 662 2 2
MIRT543589 KIAA1549 KIAA1549 2 2
MIRT543955 RNF20 ring finger protein 20 2 2
MIRT544043 C9orf64 chromosome 9 open reading frame 64 2 4
MIRT548064 GIGYF1 GRB10 interacting GYF protein 1 2 2
MIRT548240 FBXW7 F-box and WD repeat domain containing 7 2 2
MIRT548442 EIF1AX eukaryotic translation initiation factor 1A, X-linked 2 2
MIRT548623 DAZAP1 DAZ associated protein 1 2 4
MIRT548770 COLEC12 collectin subfamily member 12 2 2
MIRT549506 HDDC2 HD domain containing 2 2 4
MIRT551924 AKAP8 A-kinase anchoring protein 8 2 4
MIRT555656 PGRMC1 progesterone receptor membrane component 1 2 2
MIRT556286 MAP3K5 mitogen-activated protein kinase kinase kinase 5 2 2
MIRT557012 HOXD13 homeobox D13 2 4
MIRT563907 CLSPN claspin 2 2
MIRT565527 SON SON DNA binding protein 2 2
MIRT568000 COMMD2 COMM domain containing 2 2 2
MIRT569831 PLA2G16 phospholipase A2 group XVI 2 4
MIRT573905 PARP1 poly(ADP-ribose) polymerase 1 2 2
MIRT616589 KLHL9 kelch like family member 9 2 2
MIRT617137 ZNF556 zinc finger protein 556 2 2
MIRT617400 API5 apoptosis inhibitor 5 2 2
MIRT617455 CCS copper chaperone for superoxide dismutase 2 2
MIRT617799 ZNF793 zinc finger protein 793 2 2
MIRT618190 MACC1 MACC1, MET transcriptional regulator 2 2
MIRT618303 GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase 2 2
MIRT618329 ZNF813 zinc finger protein 813 2 2
MIRT618820 PHF20 PHD finger protein 20 2 2
MIRT619153 PPDPF pancreatic progenitor cell differentiation and proliferation factor 2 2
MIRT619530 ZNF708 zinc finger protein 708 2 2
MIRT619849 KIR3DX1 killer cell immunoglobulin like receptor, three Ig domains X1 2 2
MIRT620806 SLC26A2 solute carrier family 26 member 2 2 2
MIRT621312 YIPF4 Yip1 domain family member 4 2 2
MIRT621358 GUCA1B guanylate cyclase activator 1B 2 2
MIRT621366 ART4 ADP-ribosyltransferase 4 (Dombrock blood group) 2 2
MIRT621547 ZMYM1 zinc finger MYM-type containing 1 2 2
MIRT621883 TAOK1 TAO kinase 1 2 2
MIRT622451 RNF19B ring finger protein 19B 2 2
MIRT623404 KREMEN1 kringle containing transmembrane protein 1 2 2
MIRT623587 IPO9 importin 9 2 2
MIRT623974 FAM63A MINDY lysine 48 deubiquitinase 1 2 2
MIRT624086 DPP8 dipeptidyl peptidase 8 2 2
MIRT624108 DNAH10OS dynein axonemal heavy chain 10 opposite strand 2 2
MIRT632486 RNF8 ring finger protein 8 2 2
MIRT634057 PLIN3 perilipin 3 2 2
MIRT634657 GDE1 glycerophosphodiester phosphodiesterase 1 2 2
MIRT640682 MCUR1 mitochondrial calcium uniporter regulator 1 2 2
MIRT641242 CENPN centromere protein N 2 2
MIRT642260 ZNF677 zinc finger protein 677 2 2
MIRT642954 RELA RELA proto-oncogene, NF-kB subunit 2 2
MIRT644326 IPP intracisternal A particle-promoted polypeptide 2 2
MIRT644632 ICA1L islet cell autoantigen 1 like 2 2
MIRT645721 POLR3A RNA polymerase III subunit A 2 2
MIRT647850 LYPLA1 lysophospholipase I 2 2
MIRT649281 NEK8 NIMA related kinase 8 2 2
MIRT650038 VHL von Hippel-Lindau tumor suppressor 2 2
MIRT650354 RRP36 ribosomal RNA processing 36 2 2
MIRT651144 ZNF384 zinc finger protein 384 2 2
MIRT651778 UTP6 UTP6, small subunit processome component 2 2
MIRT652576 TLCD2 TLC domain containing 2 2 2
MIRT654621 PTPRJ protein tyrosine phosphatase, receptor type J 2 2
MIRT656023 MYO5A myosin VA 2 2
MIRT656105 MSRB3 methionine sulfoxide reductase B3 2 2
MIRT657749 GMEB1 glucocorticoid modulatory element binding protein 1 2 2
MIRT657924 GATSL2 cytosolic arginine sensor for mTORC1 subunit 2 2 2
MIRT658848 DUSP19 dual specificity phosphatase 19 2 2
MIRT659100 DENND6A DENN domain containing 6A 2 2
MIRT659153 DCX doublecortin 2 2
MIRT660870 ADRBK2 G protein-coupled receptor kinase 3 2 2
MIRT661941 FAHD1 fumarylacetoacetate hydrolase domain containing 1 2 2
MIRT663577 C10orf32 BLOC-1 related complex subunit 7 2 2
MIRT664625 WDPCP WD repeat containing planar cell polarity effector 2 4
MIRT666562 RHOBTB3 Rho related BTB domain containing 3 2 2
MIRT669992 GPR156 G protein-coupled receptor 156 2 4
MIRT670445 RSBN1L round spermatid basic protein 1 like 2 2
MIRT670853 IFNAR1 interferon alpha and beta receptor subunit 1 2 4
MIRT671942 SPPL3 signal peptide peptidase like 3 2 2
MIRT674269 LMOD3 leiomodin 3 2 2
MIRT674424 MIOX myo-inositol oxygenase 2 4
MIRT674982 ATP5G1 ATP synthase, H+ transporting, mitochondrial Fo complex subunit C1 (subunit 9) 2 2
MIRT675038 BACE2 beta-site APP-cleaving enzyme 2 2 4
MIRT675309 C2orf68 chromosome 2 open reading frame 68 2 2
MIRT675641 TTPAL alpha tocopherol transfer protein like 2 2
MIRT688688 CPS1 carbamoyl-phosphate synthase 1 2 2
MIRT689369 ZNF101 zinc finger protein 101 2 2
MIRT689605 AKAP6 A-kinase anchoring protein 6 2 2
MIRT691715 LARS leucyl-tRNA synthetase 2 2
MIRT695473 TRAT1 T-cell receptor associated transmembrane adaptor 1 2 2
MIRT695530 MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2 2 2
MIRT695878 CACNG8 calcium voltage-gated channel auxiliary subunit gamma 8 2 2
MIRT696586 ORMDL2 ORMDL sphingolipid biosynthesis regulator 2 2 2
MIRT703007 HEATR5A HEAT repeat containing 5A 2 2
MIRT707942 PHKA1 phosphorylase kinase regulatory subunit alpha 1 2 2
MIRT709765 GPR183 G protein-coupled receptor 183 2 2
MIRT710332 ZNF669 zinc finger protein 669 2 2
MIRT713249 ZFP30 ZFP30 zinc finger protein 2 2
MIRT716613 RBM18 RNA binding motif protein 18 2 2
MIRT733414 BAG2 BCL2 associated athanogene 2 2 0
MIRT756135 THSD7A thrombospondin type 1 domain containing 7A 3 1
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-1 Anthocyanin NULL 145858 Microarray apoE−/− mice 22253797 2012 down-regulated
miR-1 Caffeic acid NULL 689043 Microarray apoE−/− mice 22253797 2012 down-regulated
miR-1 Catechin approved 9064 Microarray apoE−/− mice 22253797 2012 up-regulated
miR-1 Curcumin NULL 969516 Microarray apoE−/− mice 22253797 2012 down-regulated
miR-1 Ferulic acid NULL 445858 Microarray apoE−/− mice 22253797 2012 down-regulated
miR-1 Hesperidin NULL 10621 Microarray apoE−/− mice 22253797 2012 up-regulated
miR-1 Quercetin NULL 5280343 Microarray apoE−/− mice 22253797 2012 down-regulated
miR-1 Galactose NULL 6036 Quantitative real-time PCR lens 22736950 2012 up-regulated
miR-1 Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) NULL 8490 Microarray mouse brain 19270793 2009 down-regulated
miR-1 Trichostatin A (TSA) NULL 444732 Quantitative real-time PCR myocardial differentiation of mouse ES cells 19521018 2009 down-regulated
miR-1 Sulfonyl-hydrazone-1 (SHZ) NULL NULL Quantitative real-time PCR Murine broblast-derived Induced pluripotent stem cells 21445862 2011 up-regulated
miR-1 Cocaine NULL 446220 Next-generation sequencing ventral striatum 21708909 2011 up-regulated
miR-1 Atorvastatin approved 60823 Quantitative real-time PCR Cardiomyocyte 23860036 2013 down-regualted
miR-1 Glucose NULL 5793 Quantitative real-time PCR endothelial cells 24394957 2014 down-regulated
miR-1 Docosahexaenoic acid NULL 445580 Quantitative real-time PCR Caco-2 cells 24623846 2014 up-regulated
miR-1 Palmitic acid approved 985 Quantitative real-time PCR Caco-2 cells 24623846 2014 up-regulated
miR-1 17beta-estradiol (E2) approved 5757 Microarray MCF-7AKT breast cancer cells 19528081 2009 down-regulated
miR-1 Essential amino acids (EAA) NULL NULL Quantitative real-time PCR skeletal muscle of young adults 19828686 2009 up-regulated
miR-1 Hydrogen peroxide (H2O2) NULL 784 Quantitative real-time PCR Human umbilical vein endothelial cells 21527937 2011 down-regulated
miR-1 Trichostatin A (TSA) NULL 444732 Microarray apoptosis-resistant breast cancer cells 21971930 2011 up-regulated
miR-1 Arsenic trioxide approved 14888 Quantitative real-time PCR acute promyelocytic leukemia 22072212 2012 up-regulated
miR-1 5-Fluorouracil approved 3385 Microarray CNE cells 22614822 2012 up-regulated
miR-1 Bicalutamide approved 2375 Microarray prostate 22674191 2012 up-regulated
miR-1 Arsenic trioxide approved 14888 Quantitative real-time PCR cardia 22889704 2012 up-regulated
miR-1 Perfluorooctane sulfonate NULL 74483 Microarray zebrafish embryos 20878907 2011 up-regulated
miR-1 Quinidine approved 441074 Quantitative real-time PCR myocardial infarction (MI) rats 19775284 2009 up-regulated
miR-1 Tanshinone IIA NULL 164676 Quantitative real-time PCR myocardial infarction (MI) rats 19775284 2009 down-regulated
miR-1 Tanshinone IIA NULL 164676 Quantitative real-time PCR post-infarction rat cardiomyocytes 21220930 2011 down-regulated
miR-1 Isoproterenol approved 3779 Quantitative real-time PCR heart 22847192 2012 down-regulated
miR-1 Dexamethasone approved 5743 Microarray adrenals and granulosa cells 24205079 2014 up-regulated
miR-1 Thiourea (TU) NULL 737139 Quantitative real-time PCR skeletal muscle and heart 22142802 2012 up-regulated
miR-1 Thiourea (TU) NULL 737139 Quantitative real-time PCR skeletal muscle and heart 22142802 2012 down-regulated
miR-1 Isoproterenol approved 3779 Quantitative real-time PCR heart 22847192 2012 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-1303 Oxaliplatin 6857599 NSC266046 approved sensitive High Colorectal Cancer cell line (RKO)
hsa-miR-1303 Oxaliplatin 6857599 NSC266046 approved resistant High Colorectal Cancer cell line (HT-29)
hsa-miR-1303 Imatinib 5291 NSC743414 approved sensitive High Gastrointestinal Stromal Tumor cell line (882R-NC, 882R-OE, 882R-KD)
hsa-miR-1303 Fulvestrant 17756771 NSC719276 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-miR-1303 Rituximab sensitive High Diffuse Large B-Cell Lymphoma cell line (DB, NU-DHL-1, NU-DUL-1, MC-116, SU-DHL-4, SU-DHL-5, FARAGE, HBL-1, OCI-Ly3, OCI-Ly7, OCI-Ly8, OCI-Ly19, RIVA, SU-DHL-8, U2932)
hsa-miR-1303 Etoposide 36462 NSC141540 approved resistant High Colorectal Cancer cell line (HCT8)
hsa-miR-1303 Doxorubicin 31703 NSC123127 approved resistant High Colorectal Cancer cell line (HCT8)
hsa-miR-1303 Vinorelbine 44424639 approved resistant High Colorectal Cancer cell line (HCT8)
hsa-miR-1303 Vincristine 5978 approved resistant High Colorectal Cancer cell line (HCT8)
hsa-miR-1303 Paclitaxel 36314 NSC125973 approved resistant High Colorectal Cancer cell line (HCT8)
hsa-mir-1303 Dabrafenib 44462760 NSC764134 approved sensitive cell line (A375)
hsa-mir-1303 Cisplatin 5460033 NSC119875 approved resistant cell line (W1)
hsa-mir-1303 Topotecan 60699 NSC609699 approved resistant cell line (W1)
hsa-mir-1303 Androstenedione+Letrozole resistant cell line (MCF-7)
hsa-miR-1303 Gefitinib 123631 NSC715055 approved sensitive cell line (HCC827)
hsa-miR-1303 Osimertinib 71496458 NSC779217 approved sensitive cell line (HCC827)
hsa-miR-1303 Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-1303 Vemurafenib 42611257 NSC761431 approved resistant cell line (451Lu)
hsa-miR-1303 Palbociclib 5330286 NSC758247 approved resistant tissue (breast cancer)
hsa-miR-1303 Cisplatin 5460033 NSC119875 approved sensitive cell line
hsa-miR-1303 Gefitinib 123631 NSC715055 approved sensitive cell line (HCC827)
hsa-miR-1303 Paclitaxel 36314 NSC125973 approved resistant cell line (BAS)
hsa-miR-1303 Doxorubicin 31703 NSC123127 approved resistant cell line (HS578T)
hsa-miR-1303 Cisplatin 5460033 NSC119875 approved resistant cell line (CP20)
hsa-miR-1303 Cisplatin 5460033 NSC119875 approved sensitive cell line (MGC-803)
hsa-miR-1303 Oxaliplatin 6857599 NSC266046 approved sensitive cell line (IGROV-1)
hsa-miR-1303 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)

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