pre-miRNA Information
pre-miRNA hsa-mir-4699   
Genomic Coordinates chr12: 81158388 - 81158461
Description Homo sapiens miR-4699 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4699-3p
Sequence 46| AAUUUACUCUGCAAUCUUCUCC |67
Evidence Experimental
Experiments Illumina
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN20804631 9 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1419816940 6 dbSNP
rs919201645 9 dbSNP
rs950685323 11 dbSNP
rs985212635 14 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol POLR3F   
Synonyms RPC39, RPC6
Description RNA polymerase III subunit F
Transcript NM_006466   
Expression
Putative miRNA Targets on POLR3F
3'UTR of POLR3F
(miRNA target sites are highlighted)
>POLR3F|NM_006466|3'UTR
   1 TAGAGAGCTATGAACTTTATTGACATTTTGCAAATGAAGTTACTTAGGGAGCAGATAATTTAATTCATGATGGAACACGA
  81 AATCTCCTTGAAAGCAAACTTCACAATAATGGACGTAGACTTGCTGCTATGAAAACATATTTTTTTTATTTATGAAGACT
 161 AAATTTATATTGGTAAAATAGCCAGTAGAATATGAAAGAAATAAGGTTAGTAGTGAAATTCATTCTTCAATAAATAAAAC
 241 ACTTTGAAACTCCGGAGGACCACATCTTTCAAGACTTCTGATGGGTCAAGGAAAAAGATGCCAACATACCCGTATTTACC
 321 AAGTACTATGATAATGGCTAGAGTATAAAAATGTTCTTTTTAAAGTTATTTATTAAGTTCTTCATTGGAAGTTTTTTTTT
 401 ATATCTGGTTCACTACCACCATTTTCTGTTTCCTACTTTCTCAGTGGTTTCATTGAAAAGAAATTAGAAGGGGTTAAAGG
 481 CAGGAATAGCAAAGAGTGCAAACTTGGGGTATGACTGGGGGAGAGTGGAACATGCCTTTTCCGCACAATATTAATTCCTT
 561 TTTGTATCAGAAATGTTCTTTTAGGAGATTATGCTACCATACTTACTTCAAACCCAATGACTACTGTCAAGGACATATTT
 641 TCAGTACATAAATACTATCATTTTCATTCTAAAGAATATTTTCACTGTTCCTTCTTTCTTAAAGTCTTATGTTTCACTCT
 721 TTAACTCAAATGTATTCTTTGTTAGAATTTACCCTAGATTCTTATTTAATGTCTGCAGTAGACTGAATGTTTGTGTGCCC
 801 CCAGAATTCTAATGTTGAAATCTCATTTCCAATGTGATGGTATTTGGAGGTGGGGCTTTTGGTAAGTGATAGGTCAGGAG
 881 AGTAACAGCGCTCATGAATGGGATTAGTGCCCTTATATAAAGAGACCCAGAGAGCTCCATCACCCCTTCTGCCATGTGAA
 961 AGGGAGAAGACAAACATCCACGAACCAGGAAGTGGGTCCTCACCAGAAAACAAATCTGTAAGCACCTTGATCTTGGACTT
1041 CCCAGCCTCCAGAATTGTGAGAAATAAATTTCTGTTGTTGATAAACCACC
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' ccUCUUCUAACGUC-UCA-UUUAa 5'
            | |||:||  || ||| |||| 
Target 5' aaATAAGGTT--AGTAGTGAAATt 3'
199 - 220 128.00 -8.20
2
miRNA  3' ccUCUUCUAACG-UC-UCAUUUAa 5'
            |||  ||||: || | ||||| 
Target 5' ccAGA--ATTGTGAGAAATAAATt 3'
1049 - 1070 128.00 -5.60
3
miRNA  3' ccuCU-UCUA-ACGUCUCAUUuaa 5'
             || ||:|  | |||||||   
Target 5' agtGATAGGTCAGGAGAGTAAcag 3'
865 - 888 119.00 -8.72
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSM5699858 1 COSMIC
COSN26989861 24 COSMIC
COSN31535786 31 COSMIC
COSN30468981 38 COSMIC
COSN30512278 66 COSMIC
COSN30159926 70 COSMIC
COSN31527278 79 COSMIC
COSN31573322 80 COSMIC
COSN31577635 95 COSMIC
COSN16132474 103 COSMIC
COSN31530014 147 COSMIC
COSN1245977 160 COSMIC
COSN20093694 255 COSMIC
COSN32064322 781 COSMIC
COSN24485542 852 COSMIC
COSN30083318 979 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1397721178 1 dbSNP
rs764258090 4 dbSNP
rs932287034 8 dbSNP
rs202010170 11 dbSNP
rs914312036 12 dbSNP
rs1475239270 15 dbSNP
rs1336884275 16 dbSNP
rs752056097 21 dbSNP
rs938997816 23 dbSNP
rs1450817842 26 dbSNP
rs990855528 31 dbSNP
rs762350326 37 dbSNP
rs377200298 40 dbSNP
rs1219679949 45 dbSNP
rs1169433109 50 dbSNP
rs750811574 52 dbSNP
rs1365066129 56 dbSNP
rs985247763 62 dbSNP
rs1459673232 69 dbSNP
rs1229462493 70 dbSNP
rs1416793749 79 dbSNP
rs902755165 80 dbSNP
rs935594412 83 dbSNP
rs912308293 89 dbSNP
rs943752486 95 dbSNP
rs756819329 97 dbSNP
rs1315557275 101 dbSNP
rs779918772 115 dbSNP
rs560133385 116 dbSNP
rs527940667 120 dbSNP
rs1197999417 122 dbSNP
rs1333118572 130 dbSNP
rs1272828677 132 dbSNP
rs1023695725 137 dbSNP
rs552600808 139 dbSNP
rs1441481708 140 dbSNP
rs75195416 140 dbSNP
rs79286991 140 dbSNP
rs995338155 140 dbSNP
rs1472174142 148 dbSNP
rs1330795235 149 dbSNP
rs750863074 163 dbSNP
rs936966858 172 dbSNP
rs1182430489 173 dbSNP
rs1053945135 177 dbSNP
rs1326289499 179 dbSNP
rs895187504 180 dbSNP
rs1012193512 183 dbSNP
rs1405276694 186 dbSNP
rs1157492909 194 dbSNP
rs1470196861 198 dbSNP
rs746764867 199 dbSNP
rs986711422 202 dbSNP
rs1181013240 206 dbSNP
rs549163757 216 dbSNP
rs778756558 216 dbSNP
rs869243242 216 dbSNP
rs1252783007 236 dbSNP
rs1024896085 242 dbSNP
rs1417197953 251 dbSNP
rs906628302 254 dbSNP
rs963644295 255 dbSNP
rs1005354792 284 dbSNP
rs1421760366 286 dbSNP
rs914300339 292 dbSNP
rs1055175 293 dbSNP
rs1311286334 297 dbSNP
rs1351464584 309 dbSNP
rs1281255716 311 dbSNP
rs768509734 312 dbSNP
rs1374987883 313 dbSNP
rs1448819909 330 dbSNP
rs947155312 331 dbSNP
rs6111985 333 dbSNP
rs924146878 341 dbSNP
rs961491975 352 dbSNP
rs1400819690 357 dbSNP
rs1371849175 360 dbSNP
rs1386532075 360 dbSNP
rs1223667783 362 dbSNP
rs1310463978 364 dbSNP
rs974043706 371 dbSNP
rs1453126966 382 dbSNP
rs1394935517 383 dbSNP
rs1194727962 384 dbSNP
rs1479200343 385 dbSNP
rs113243239 386 dbSNP
rs953726848 389 dbSNP
rs948050312 392 dbSNP
rs1208747659 393 dbSNP
rs538046870 400 dbSNP
rs776365282 401 dbSNP
rs965170412 406 dbSNP
rs146172510 409 dbSNP
rs1468550255 419 dbSNP
rs1431037804 425 dbSNP
rs886906616 446 dbSNP
rs139124260 447 dbSNP
rs1019469307 457 dbSNP
rs1375433070 458 dbSNP
rs1055177 472 dbSNP
rs1416556170 474 dbSNP
rs1053998986 482 dbSNP
rs916838134 484 dbSNP
rs1172061757 488 dbSNP
rs1475873296 491 dbSNP
rs975095016 492 dbSNP
rs553768449 494 dbSNP
rs1185987216 499 dbSNP
rs1485380597 505 dbSNP
rs1281018275 508 dbSNP
rs1415216456 518 dbSNP
rs948266534 519 dbSNP
rs1336268911 522 dbSNP
rs1272039230 534 dbSNP
rs1021734646 535 dbSNP
rs572078486 537 dbSNP
rs968495059 543 dbSNP
rs977609693 544 dbSNP
rs188529932 549 dbSNP
rs143898119 557 dbSNP
rs1450843974 569 dbSNP
rs935462130 594 dbSNP
rs1170197471 600 dbSNP
rs1410877767 604 dbSNP
rs1426122342 618 dbSNP
rs1379647734 626 dbSNP
rs1004997396 631 dbSNP
rs74961603 633 dbSNP
rs1055179 634 dbSNP
rs753684560 644 dbSNP
rs1163032486 645 dbSNP
rs1474946434 657 dbSNP
rs1258339356 672 dbSNP
rs576324578 683 dbSNP
rs897027902 684 dbSNP
rs1479618668 697 dbSNP
rs1300852465 705 dbSNP
rs774386109 708 dbSNP
rs1205027675 711 dbSNP
rs1343887507 713 dbSNP
rs1319708152 718 dbSNP
rs762103478 720 dbSNP
rs759680785 721 dbSNP
rs41276440 724 dbSNP
rs1335022700 740 dbSNP
rs1280135056 756 dbSNP
rs1314266858 761 dbSNP
rs1435566578 763 dbSNP
rs373533784 771 dbSNP
rs948327731 772 dbSNP
rs1298093633 773 dbSNP
rs1238691136 780 dbSNP
rs1402875336 787 dbSNP
rs1026786944 791 dbSNP
rs1461129197 792 dbSNP
rs1418759171 794 dbSNP
rs1417385537 795 dbSNP
rs1247226396 797 dbSNP
rs1407228005 799 dbSNP
rs5867 800 dbSNP
rs1459003343 801 dbSNP
rs931336627 802 dbSNP
rs1133724 803 dbSNP
rs1266841522 809 dbSNP
rs1174465107 812 dbSNP
rs1213110859 818 dbSNP
rs1417539215 821 dbSNP
rs1465154730 835 dbSNP
rs1315792868 839 dbSNP
rs1172070141 843 dbSNP
rs1019317337 845 dbSNP
rs1403041902 847 dbSNP
rs1439286536 854 dbSNP
rs1241548884 862 dbSNP
rs1325672183 862 dbSNP
rs887213449 863 dbSNP
rs1391795030 871 dbSNP
rs965396390 874 dbSNP
rs150916085 883 dbSNP
rs1344717524 887 dbSNP
rs1436841521 888 dbSNP
rs1040887064 890 dbSNP
rs1393122755 891 dbSNP
rs1192849607 892 dbSNP
rs923677963 896 dbSNP
rs764554962 911 dbSNP
rs1184380278 913 dbSNP
rs1336940382 917 dbSNP
rs1485319712 925 dbSNP
rs560070831 927 dbSNP
rs572521522 929 dbSNP
rs1356546898 931 dbSNP
rs997206854 937 dbSNP
rs1234079407 943 dbSNP
rs139416012 954 dbSNP
rs1332008425 956 dbSNP
rs1303809446 959 dbSNP
rs1380766413 963 dbSNP
rs546220245 972 dbSNP
rs989609171 973 dbSNP
rs1319941049 982 dbSNP
rs1021284084 987 dbSNP
rs968756133 990 dbSNP
rs1266412616 992 dbSNP
rs150024222 999 dbSNP
rs1190702695 1011 dbSNP
rs1201348277 1015 dbSNP
rs948320692 1024 dbSNP
rs1046619335 1025 dbSNP
rs1240550440 1028 dbSNP
rs1261985180 1036 dbSNP
rs532059872 1039 dbSNP
rs1195284280 1041 dbSNP
rs2424214 1043 dbSNP
rs959805919 1047 dbSNP
rs6111986 1048 dbSNP
rs1258147291 1058 dbSNP
rs376365148 1058 dbSNP
rs992309126 1060 dbSNP
rs1425798906 1063 dbSNP
rs1460346792 1073 dbSNP
rs778130966 1084 dbSNP
rs918128427 1086 dbSNP
rs528955402 1087 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions Hela
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1048187. RNA binding protein: AGO2. Condition:Hela_AGO2_CLIP_control ...

- Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al., 2013, Cell.

Article - Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al.
- Cell, 2013
The induction of pluripotency or trans-differentiation of one cell type to another can be accomplished with cell-lineage-specific transcription factors. Here, we report that repression of a single RNA binding polypyrimidine-tract-binding (PTB) protein, which occurs during normal brain development via the action of miR-124, is sufficient to induce trans-differentiation of fibroblasts into functional neurons. Besides its traditional role in regulated splicing, we show that PTB has a previously undocumented function in the regulation of microRNA functions, suppressing or enhancing microRNA targeting by competitive binding on target mRNA or altering local RNA secondary structure. A key event during neuronal induction is the relief of PTB-mediated blockage of microRNA action on multiple components of the REST complex, thereby derepressing a large array of neuronal genes, including miR-124 and multiple neuronal-specific transcription factors, in nonneuronal cells. This converts a negative feedback loop to a positive one to elicit cellular reprogramming to the neuronal lineage.
LinkOut: [PMID: 23313552]
CLIP-seq Support 1 for dataset GSM1048187
Method / RBP HITS-CLIP / AGO2
Cell line / Condition Hela / Hela_AGO2_CLIP_control
Location of target site ENST00000377603.4 | 3UTR | GUGUUACCCAGCAUGCUGUUGGCAUUGUUGUAAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23313552 / GSE42701
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
88 hsa-miR-4699-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT056239 RAB18 RAB18, member RAS oncogene family 2 2
MIRT080536 PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 2 2
MIRT095600 NR3C1 nuclear receptor subfamily 3 group C member 1 2 2
MIRT128911 KMT2A lysine methyltransferase 2A 2 2
MIRT161904 FXR1 FMR1 autosomal homolog 1 2 4
MIRT177614 UBE2D1 ubiquitin conjugating enzyme E2 D1 2 4
MIRT231364 EDEM3 ER degradation enhancing alpha-mannosidase like protein 3 2 6
MIRT285164 SERBP1 SERPINE1 mRNA binding protein 1 2 2
MIRT307337 SEC22C SEC22 homolog C, vesicle trafficking protein 2 2
MIRT317083 DEK DEK proto-oncogene 2 2
MIRT347692 LSM14A LSM14A, mRNA processing body assembly factor 2 2
MIRT358438 STC2 stanniocalcin 2 2 2
MIRT362592 PURB purine rich element binding protein B 2 4
MIRT441441 HAVCR1 hepatitis A virus cellular receptor 1 2 2
MIRT445264 LOH12CR2 loss of heterozygosity, 12, chromosomal region 2 (non-protein coding) 2 4
MIRT447097 SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 2 2
MIRT449013 ANKRD17 ankyrin repeat domain 17 2 2
MIRT450358 SETD9 SET domain containing 9 2 2
MIRT454976 MYC MYC proto-oncogene, bHLH transcription factor 2 2
MIRT461922 NECAB3 N-terminal EF-hand calcium binding protein 3 2 2
MIRT465191 TRPS1 transcriptional repressor GATA binding 1 2 2
MIRT467685 SLC38A2 solute carrier family 38 member 2 2 4
MIRT468003 SKI SKI proto-oncogene 2 2
MIRT473127 MLLT10 MLLT10, histone lysine methyltransferase DOT1L cofactor 2 2
MIRT476370 GIGYF1 GRB10 interacting GYF protein 1 2 2
MIRT477067 FAM208B family with sequence similarity 208 member B 2 4
MIRT479950 CBX4 chromobox 4 2 4
MIRT481092 B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 2 2
MIRT481932 ANKRD11 ankyrin repeat domain 11 2 12
MIRT482239 AHCY adenosylhomocysteinase 2 2
MIRT485804 ARPP19 cAMP regulated phosphoprotein 19 2 2
MIRT492026 TWF1 twinfilin actin binding protein 1 2 2
MIRT494389 CALM3 calmodulin 3 2 2
MIRT504115 GPR158 G protein-coupled receptor 158 2 2
MIRT506346 NUP54 nucleoporin 54 2 4
MIRT510081 PPWD1 peptidylprolyl isomerase domain and WD repeat containing 1 2 4
MIRT521019 SLC8A1 solute carrier family 8 member A1 2 2
MIRT524709 BTBD3 BTB domain containing 3 2 2
MIRT524989 AGO2 argonaute 2, RISC catalytic component 2 6
MIRT525003 ACVR1B activin A receptor type 1B 2 2
MIRT528064 OLAH oleoyl-ACP hydrolase 2 2
MIRT528865 C1orf147 chromosome 1 open reading frame 147 2 2
MIRT532182 DOCK7 dedicator of cytokinesis 7 2 2
MIRT533592 TOB1 transducer of ERBB2, 1 2 6
MIRT538835 C16orf70 chromosome 16 open reading frame 70 2 2
MIRT539488 ACVR1C activin A receptor type 1C 2 2
MIRT539542 ABCD2 ATP binding cassette subfamily D member 2 2 2
MIRT542123 VENTX VENT homeobox 2 2
MIRT542993 ELOVL5 ELOVL fatty acid elongase 5 2 2
MIRT543067 ATXN7L3B ataxin 7 like 3B 2 2
MIRT543370 CYB5B cytochrome b5 type B 2 2
MIRT545080 TSEN34 tRNA splicing endonuclease subunit 34 2 2
MIRT545258 TRIM36 tripartite motif containing 36 2 4
MIRT549144 BRIX1 BRX1, biogenesis of ribosomes 2 2
MIRT549403 AKAP1 A-kinase anchoring protein 1 2 2
MIRT552143 MRPL34 mitochondrial ribosomal protein L34 2 2
MIRT554781 RHEBP1 RHEB pseudogene 1 2 4
MIRT555991 NFYB nuclear transcription factor Y subunit beta 2 2
MIRT556425 LONRF3 LON peptidase N-terminal domain and ring finger 3 2 2
MIRT558325 DNAJC28 DnaJ heat shock protein family (Hsp40) member C28 2 4
MIRT561357 YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta 2 2
MIRT562240 HMGB1 high mobility group box 1 2 2
MIRT562269 GOLT1B golgi transport 1B 2 2
MIRT564020 FAM103A1 family with sequence similarity 103 member A1 2 2
MIRT564832 ZBTB16 zinc finger and BTB domain containing 16 2 2
MIRT565350 TMED2 transmembrane p24 trafficking protein 2 2 2
MIRT565678 SET SET nuclear proto-oncogene 2 2
MIRT576547 Txlna taxilin alpha 2 2
MIRT609358 ZNF664 zinc finger protein 664 2 2
MIRT610646 CTGF connective tissue growth factor 2 2
MIRT624681 ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 2 2
MIRT637118 AGTPBP1 ATP/GTP binding protein 1 2 2
MIRT639955 PRRC2B proline rich coiled-coil 2B 2 2
MIRT644051 WWC2 WW and C2 domain containing 2 2 2
MIRT650463 SLC35B1 solute carrier family 35 member B1 2 2
MIRT651094 ZNF516 zinc finger protein 516 2 2
MIRT655268 PER2 period circadian clock 2 2 2
MIRT657450 HEYL hes related family bHLH transcription factor with YRPW motif-like 2 2
MIRT692248 POLR3F RNA polymerase III subunit F 2 2
MIRT695239 PBK PDZ binding kinase 2 2
MIRT696024 NDUFS3 NADH:ubiquinone oxidoreductase core subunit S3 2 2
MIRT698486 TIAL1 TIA1 cytotoxic granule associated RNA binding protein like 1 2 2
MIRT700581 PRSS22 protease, serine 22 2 2
MIRT704540 CNEP1R1 CTD nuclear envelope phosphatase 1 regulatory subunit 1 2 2
MIRT704723 CEP135 centrosomal protein 135 2 2
MIRT705194 BTG1 BTG anti-proliferation factor 1 2 2
MIRT710286 CSNK1G3 casein kinase 1 gamma 3 2 2
MIRT719623 TUBGCP3 tubulin gamma complex associated protein 3 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-4699 Paclitaxel 36314 NSC125973 approved sensitive cell line (A2780)
hsa-miR-4699-3p Docetaxel+Cisplatin+5-Fluorouracil resistant tissue (hypopharyngeal squamous cell carcinoma)

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