pre-miRNA Information | |
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pre-miRNA | hsa-mir-4796 |
Genomic Coordinates | chr3: 114743445 - 114743525 |
Description | Homo sapiens miR-4796 stem-loop |
Comment | None |
RNA Secondary Structure |
Mature miRNA Information | ||||||||||
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Mature miRNA | hsa-miR-4796-5p | |||||||||
Sequence | 9| UGUCUAUACUCUGUCACUUUAC |30 | |||||||||
Evidence | Experimental | |||||||||
Experiments | Illumina | |||||||||
SNPs in miRNA |
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Putative Targets |
miRNA Expression profile | |
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Human miRNA Tissue Atlas | |
Circulating MicroRNA Expression Profiling |
Gene Information | |||||||||||||||||||||
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Gene Symbol | INPP5B | ||||||||||||||||||||
Synonyms | 5PTase | ||||||||||||||||||||
Description | inositol polyphosphate-5-phosphatase B | ||||||||||||||||||||
Transcript | NM_005540 | ||||||||||||||||||||
Expression | |||||||||||||||||||||
Putative miRNA Targets on INPP5B | |||||||||||||||||||||
3'UTR of INPP5B (miRNA target sites are highlighted) |
>INPP5B|NM_005540|3'UTR 1 GCCTCTCTCTCCTCCTATTTTACTTGAGGCTGCCAATTACCAGCCCCACCTGTTTCAGCTCAAGAGATGCCTTAAGATAA 81 TTATGTGAGGCCACTTGGTAGCAAGAATGGCAGCTATTTCCTGAGCCTAGTACCCCAATTAAGCCCACCATTGGTTAGCA 161 CACTCAGCGCTGTGAGTCGTGAAGACACGGGAGAAAATCCACCATAATAAAACTGACATTCAATTTTCAACTTTAGTTAT 241 TTAACACAGATTTTTTTATTTTTTATTTTTTTTTATTTTGAGACGGAGTTTTGCTCTGTCGCGCAGGGTGGAGTGCGGTG 321 GCACGATCTCGGCTCACTGCAACCTCTGCCTCCTGGGTGCAAGCAATTATCCTGCCTCAGCCTCCCGAGTAGCTGGGACT 401 GCAGGCACACACTGCCACGCCCAGCTAATTTTTTGCATTTTAGTAGAGACGGGGTTTCACCGTGTTGCCCAGGCTGTTCT 481 AAAACTCCTGAACTCAGGTAATCTGCCTGCCTCGGCCTCCCCAAGTGCTAGGATTACAGATGTGAGCCACCACGCCCGGC 561 CTTTTTTTTTTTTTTTTCTTTTTTGAGATGGAGTTTCACTCTTGTTGCCCAGGCTGGAGTGCGTTGGCGTGGTCTTGGCT 641 CACTGCAACCTCTGCCTCCTTGGTTCAAGCAATTCTCCTGCCTCAGCCTCTCGAGTAGCTGGGATTATAGGCGTCCGCCA 721 CCATGCCTGGCTAATTTTTTTGTGTGTTTTTAGTATAGACACGGTTTCACCATGTTGGCCAGGCTGGTCTCGAATGCCTG 801 GCCTCAGGTGATCCACCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGCATGAACCACCACGCCTGGCCTAAAATGTT 881 TTTAAATAACTGTACTTGTACTCACTCACCCTACCTCCAGGGCATAGTCAGTCTGGGCTGAGATCCCCATGATCAGATAT 961 TTGATGGAAAGTCCTGAAAGGCCAATGAGTTGGATGGCAAGAATGCAGGCAGAAGCTGCTGGATAAAATAGGCTACAGCC 1041 ACCTCAGATGCTTTCAGTGCTCTGTCTGAGGATGTGTATATGCATATGCAAACTCGACCCCCGTTCCTGCCCAGATAATG 1121 GCTCAATAACTCTGAGGCTGGTTGCTCAGCCTCTGAGGGCAATACAGGCATTTAAAAAATTAAAATGACCAGGCACAGTG 1201 GCTCACGCCTGTAATCTCGGCACTTTGGGAGACTGAGGTGGGAGCATCACTTGAGACCAGGAGTTTGGGACCAGGCTGGG 1281 CAACACAGGGAGACCCCCTCTCTACAAAAACATTTTTAAAAAATTAGCTGGGTGTGGTGATGCATGCCTGTGGTCCCAGT 1361 TACTTGGGAGGCTGACGTGGGTGGCTCACTTGAGCACAGGAGTTTGAGGCTGCAGTGACCTATGACCACATCACTGTACG 1441 CCAGCCCGGGTGAGAGAGGGAGACCCCGTCTCTAAAAATAAAATGTAAAATCACTGAAAAAATGAGTGTTCGGTGAAACA 1521 AGTGGGATTTTCTGGGCCAGCAAGTCTTCCAAACTGTATATGATGCATCCTGTCTCCATGTGTAATATATTTTAATGATA 1601 AATGTATTTTTAACAGTGAAAAAAAAAAAAAAA Target sites
Provided by authors
Predicted by miRanda
DRVs
SNPs
DRVs & SNPs
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miRNA-target interactions (Predicted by miRanda) |
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DRVs in gene 3'UTRs | |||||||||||||||||||||
SNPs in gene 3'UTRs |
Experimental Support 1 for Functional miRNA-Target Interaction | |
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miRNA:Target | ---- |
Validation Method |
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Conditions | Hela |
Location of target site | 3'UTR |
Tools used in this research | TargetScan , miRTarCLIP , Piranha |
Original Description (Extracted from the article) |
...
HITS-CLIP data was present in GSM1048187. RNA binding protein: AGO2. Condition:Hela_AGO2_CLIP_control
... - Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al., 2013, Cell. |
Article |
- Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al. - Cell, 2013
The induction of pluripotency or trans-differentiation of one cell type to another can be accomplished with cell-lineage-specific transcription factors. Here, we report that repression of a single RNA binding polypyrimidine-tract-binding (PTB) protein, which occurs during normal brain development via the action of miR-124, is sufficient to induce trans-differentiation of fibroblasts into functional neurons. Besides its traditional role in regulated splicing, we show that PTB has a previously undocumented function in the regulation of microRNA functions, suppressing or enhancing microRNA targeting by competitive binding on target mRNA or altering local RNA secondary structure. A key event during neuronal induction is the relief of PTB-mediated blockage of microRNA action on multiple components of the REST complex, thereby derepressing a large array of neuronal genes, including miR-124 and multiple neuronal-specific transcription factors, in nonneuronal cells. This converts a negative feedback loop to a positive one to elicit cellular reprogramming to the neuronal lineage.
LinkOut: [PMID: 23313552]
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CLIP-seq Support 1 for dataset GSM1048187 | |
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Method / RBP | HITS-CLIP / AGO2 |
Cell line / Condition | Hela / Hela_AGO2_CLIP_control |
Location of target site | ENST00000373027.1 | 3UTR | AGACACGGUUUCACC |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 23313552 / GSE42701 |
CLIP-seq Viewer | Link |
MiRNA-Target Expression Profile | |||||||
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MiRNA-Target Expression Profile (TCGA) | |||||||
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29 hsa-miR-4796-5p Target Genes:
Functional analysis:
ID | Target | Description | Validation methods | |||||||||
Strong evidence | Less strong evidence | |||||||||||
MIRT446014 | VNN1 | vanin 1 | 2 | 2 | ||||||||
MIRT493828 | FRS2 | fibroblast growth factor receptor substrate 2 | 2 | 6 | ||||||||
MIRT506324 | ONECUT2 | one cut homeobox 2 | 2 | 2 | ||||||||
MIRT515488 | PRKCD | protein kinase C delta | 2 | 4 | ||||||||
MIRT515543 | KRT222 | keratin 222 | 2 | 4 | ||||||||
MIRT518502 | DEPTOR | DEP domain containing MTOR interacting protein | 2 | 6 | ||||||||
MIRT519278 | DDX55 | DEAD-box helicase 55 | 2 | 2 | ||||||||
MIRT528638 | SENP6 | SUMO1/sentrin specific peptidase 6 | 2 | 2 | ||||||||
MIRT532130 | NOL11 | nucleolar protein 11 | 2 | 2 | ||||||||
MIRT558240 | EDA2R | ectodysplasin A2 receptor | 2 | 2 | ||||||||
MIRT562293 | GLO1 | glyoxalase I | 2 | 2 | ||||||||
MIRT575346 | Cacul1 | CDK2 associated, cullin domain 1 | 2 | 2 | ||||||||
MIRT610250 | SLC35B4 | solute carrier family 35 member B4 | 2 | 2 | ||||||||
MIRT616752 | SVOP | SV2 related protein | 2 | 2 | ||||||||
MIRT627810 | PTCHD1 | patched domain containing 1 | 2 | 4 | ||||||||
MIRT643062 | CCDC149 | coiled-coil domain containing 149 | 2 | 2 | ||||||||
MIRT652031 | LINC00598 | long intergenic non-protein coding RNA 598 | 2 | 2 | ||||||||
MIRT658708 | EMB | embigin | 2 | 2 | ||||||||
MIRT687624 | LRRC40 | leucine rich repeat containing 40 | 2 | 2 | ||||||||
MIRT692723 | INPP5B | inositol polyphosphate-5-phosphatase B | 2 | 2 | ||||||||
MIRT697508 | ZBTB7A | zinc finger and BTB domain containing 7A | 2 | 2 | ||||||||
MIRT702301 | LAMP3 | lysosomal associated membrane protein 3 | 2 | 2 | ||||||||
MIRT718288 | MINA | ribosomal oxygenase 2 | 2 | 2 | ||||||||
MIRT755767 | BRCC3 | BRCA1/BRCA2-containing complex subunit 3 | 5 | 1 | ||||||||
MIRT755769 | BARD1 | BRCA1 associated RING domain 1 | 5 | 1 | ||||||||
MIRT755770 | ATM | ATM serine/threonine kinase | 5 | 1 | ||||||||
MIRT755771 | PARP14 | poly(ADP-ribose) polymerase family member 14 | 5 | 1 | ||||||||
MIRT755775 | PARP2 | poly(ADP-ribose) polymerase 2 | 5 | 1 | ||||||||
MIRT755777 | PARP11 | poly(ADP-ribose) polymerase family member 11 | 5 | 1 |
miRNA-Drug Resistance Associations | ||||||||||||||||||||||||||||||||||||||||
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