pre-miRNA Information
pre-miRNA hsa-mir-3622b   
Genomic Coordinates chr8: 27701673 - 27701767
Description Homo sapiens miR-3622b stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-3622b-3p
Sequence 58| UCACCUGAGCUCCCGUGCCUG |78
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1232922758 2 dbSNP
rs530939348 5 dbSNP
rs1439657384 10 dbSNP
rs1157333896 12 dbSNP
rs66683138 14 dbSNP
rs1044808718 15 dbSNP
rs946438979 19 dbSNP
rs551845360 21 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol ZNF708   
Synonyms KOX8, ZNF15, ZNF15L1
Description zinc finger protein 708
Transcript NM_021269   
Expression
Putative miRNA Targets on ZNF708
3'UTR of ZNF708
(miRNA target sites are highlighted)
>ZNF708|NM_021269|3'UTR
   1 TGTGTCAAATCCTTTAGTGTATTTTCAACTTTTATTAAAACACAAGATAATTCATACTGGAGAGAAATCCTACAAATGTG
  81 ATAAATGTGGCAAAGCCTTTAACTGGCTCTTAATCCTTATGAAACAAAAGATAATTCATACTAGAGAGAAACCCTACAAA
 161 TGTAAAGAATGTGGCAAAGCATTTAACTGGTCCCTAAATCTTACTAAACATAAAAAAACTTAAACTGGAGAGAAACTACA
 241 AAGCTGGAAGACATCACAGTAATTCTGACAACACCTCAAACTTTTCTAAACATAAAATAAATCATACTGGTGAGGAACTT
 321 TAAAAATGCGAAAAATGTGACAAAATCTTTAAATGATTGTCACACTTGATTGTAGGTAAGATAATTCTTACTAGAAAAAC
 401 TCTTACAAGTGTGAAGAATGTGGCAAAATTTTTAATGAATACTCACACCTTATTGCCAGGAAAGCATTTATACTTGAGAA
 481 AAATTGTACCAATATAAAGACTGTGAAAAAGCCATTAATGTCTGCTCACATCTTACTCAACATCAGAGAGTACTTAAAAA
 561 AAGTATTATAAATTTAATTACTGTCAAAAAGTATTTCAGAAAATATAAGCTTTTAAAGTATTTATTTTGAAGACAAACAT
 641 TACAAATAAAAGAGGATTGTAATACCTTTATTTGTATCACAGATCTTATTGTACACATTTTGTACTAGAGAAAACCCTGA
 721 AGCAGTTACTTAAACTTTGTTCAACATCAGGGAATTCAGATTGGAGAAAAACCCTGCAAATGTAATAAATTTGAAAAAAA
 801 AGTTTTCCAAAACTACAACTTAGACAACACCAGAGGGTTCATACTGAGATATATTTTTGCAGATGCAGTATATATTTAAA
 881 ACATTTAATCCAAAATAAGTCTATGTAAATATCAGAGAATTCACAGTGGAAATATCTAAGGTAGGGCCGGGCATGGTGGC
 961 TCACGCCTGTAATGCCAGCACTTTGGGAGGCTGAGGTGGGCAGATCATGAGGTCAACAGATTGAGACCATCCTGGTCAAC
1041 ATGGTAAAACCCTGTCTCTACTAAAAATACAAAAATTAGCTGGGCGTGGCGGCACGTGCCTGTAGTCTCAGCTACTTGGG
1121 ACGCTGAGGCAGGAAAATCCGTTGAACCCAGGAGGCAGAGGTTGTAGTGAGCCGAGATTGCACCACTGCACTCCAGCCGG
1201 GTGACAGAGTGAGACTCCATCTCAAAAACAAACAAACTAAGGTATGGATGCTTCAGACATTACACTATATCAAAGTGCTG
1281 ACTGTTAAAAATGATCCCAAACTAACGGTAGATAAATTTATTTGTACATAACTTTAAAAGGAGTAGAAGATTTTTTGGAA
1361 GTTTGTAATTACATTCAAAGTATACTTTTTTTGTTTGTTTGTTTTCCTTGAGACAGAGTCTCTCTCTGTCGTCCAGGCTG
1441 GAGTGCAGTGGCACAATCTCAGCTCGCTGCAACCTCTGCCTCCTGGGTTCAAGCAATTCTCCTGCCTCAGCCTACTGAGT
1521 AGCTGAGATTACAGGTGCACACCACCACGTCCGGCTGACTTTTGTATTTTTAGTAGGGACGGGGTTTCACCATATTGGTC
1601 AGGGTAGTCTTGAACTCCTGACCTCATGCTCTGCCCAGCTTGGCTTCCCAAAGTGCTGTGATTACAGGCTTAAGCCACAG
1681 CGCCCGGCCCAAAGTGTTCTTTTTTCCTTGAAAAGAAGTACAGATTTTTTAAAAAGCTAATATTGCTGTGATTCAACTCT
1761 CTAGTTACTTGATGCTATTTCTTCATTTCTATTGTATTCACATGTGAAAGCATGTGATCAGTTGTCACGGCATCAAAGAT
1841 AGGAGAGTTTCTTTTTTTTTAGGTGGGCATTATTTATGACCTTTTCTTTGGAAGAGTAAGGACATTAAAATGTAACATGC
1921 ATGATGAAAATCTAAGTGGAGATGGTATTTGTGGTTAATTATGATATTGAGTGGTGCATGAGGTAGGTGTTTAGAGTAAT
2001 ATTCTTTTGCATTATAGTAAGAACATTTAAGTTTTGTTAAAATTAAAAAATTAGTACGTTATTTTACTATTTGTACTTTT
2081 ATGTAATAAAATGCAGTACATTTTTAAATTTTC
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' gucCGUG---CCCU-CGAGUCCACu 5'
             ||||   |||| ||| ||||| 
Target 5' ccaGCACTTTGGGAGGCTGAGGTGg 3'
975 - 999 138.00 -24.10
2
miRNA  3' gucCGUGCCCUCGAGUCCACu 5'
             |||:| ||  |||| || 
Target 5' aaaGCATGTGA--TCAGTTGt 3'
1807 - 1825 126.00 -10.70
3
miRNA  3' guccgugcccucGAGUCCACu 5'
                      :|:||||| 
Target 5' agtttcttttttTTTAGGTGg 3'
1846 - 1866 125.00 -9.70
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN29461212 5 COSMIC
COSN31497833 13 COSMIC
COSN30498756 24 COSMIC
COSN30458245 69 COSMIC
COSN31581739 72 COSMIC
COSN30128956 75 COSMIC
COSN27006439 82 COSMIC
COSN27006438 83 COSMIC
COSN8257298 94 COSMIC
COSN30541835 115 COSMIC
COSN30527585 129 COSMIC
COSN8605327 130 COSMIC
COSN27006437 143 COSMIC
COSN31505441 155 COSMIC
COSN30114962 211 COSMIC
COSN30474632 212 COSMIC
COSN31521328 235 COSMIC
COSN28690895 282 COSMIC
COSN31996565 532 COSMIC
COSN1762779 581 COSMIC
COSN8552270 771 COSMIC
COSN27137712 964 COSMIC
COSN28357564 974 COSMIC
COSN24902808 1036 COSMIC
COSN7118169 1141 COSMIC
COSN16718294 1493 COSMIC
COSN16447642 1693 COSMIC
COSN15150858 1723 COSMIC
COSN29679511 1852 COSMIC
COSN20115630 2051 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1459107255 2 dbSNP
rs1296302462 5 dbSNP
rs1399288210 8 dbSNP
rs759200177 9 dbSNP
rs1304715616 10 dbSNP
rs1456126823 12 dbSNP
rs1019424636 19 dbSNP
rs181100343 26 dbSNP
rs374803496 28 dbSNP
rs746471956 31 dbSNP
rs778394299 32 dbSNP
rs1193642888 36 dbSNP
rs371204394 37 dbSNP
rs368086999 39 dbSNP
rs779133798 41 dbSNP
rs553780567 44 dbSNP
rs1348477869 46 dbSNP
rs780385540 47 dbSNP
rs533868517 50 dbSNP
rs994762612 60 dbSNP
rs79205479 62 dbSNP
rs189532403 72 dbSNP
rs1323355866 73 dbSNP
rs1248364176 77 dbSNP
rs1289881717 82 dbSNP
rs769317696 91 dbSNP
rs948790275 93 dbSNP
rs1205993843 103 dbSNP
rs1225190097 106 dbSNP
rs917436135 120 dbSNP
rs925263935 123 dbSNP
rs551582864 128 dbSNP
rs1228846162 132 dbSNP
rs143269680 134 dbSNP
rs775646551 135 dbSNP
rs1169915517 141 dbSNP
rs1352324522 142 dbSNP
rs772643384 143 dbSNP
rs1345762647 146 dbSNP
rs1380998078 151 dbSNP
rs1450211303 154 dbSNP
rs1230951926 155 dbSNP
rs924845768 162 dbSNP
rs375087864 164 dbSNP
rs978429446 171 dbSNP
rs975775364 172 dbSNP
rs947006852 174 dbSNP
rs1389695095 181 dbSNP
rs1204353256 183 dbSNP
rs1168247447 210 dbSNP
rs549016806 213 dbSNP
rs1182103068 219 dbSNP
rs1421373880 219 dbSNP
rs184160345 223 dbSNP
rs139345174 226 dbSNP
rs1269883728 228 dbSNP
rs975182593 248 dbSNP
rs986300494 254 dbSNP
rs781176955 260 dbSNP
rs115298258 271 dbSNP
rs1176642591 291 dbSNP
rs1360858034 295 dbSNP
rs1450053334 302 dbSNP
rs1335813298 303 dbSNP
rs1389178385 304 dbSNP
rs114881279 305 dbSNP
rs994160575 308 dbSNP
rs897803832 318 dbSNP
rs1302122498 321 dbSNP
rs192657519 324 dbSNP
rs1342169393 328 dbSNP
rs544370999 329 dbSNP
rs575762098 330 dbSNP
rs1465635653 336 dbSNP
rs1014336171 339 dbSNP
rs1240026705 340 dbSNP
rs1026874454 341 dbSNP
rs1474772764 342 dbSNP
rs894588297 346 dbSNP
rs1430852266 352 dbSNP
rs994819557 353 dbSNP
rs1433894836 354 dbSNP
rs2997224 362 dbSNP
rs1022910547 366 dbSNP
rs1412346189 368 dbSNP
rs542159870 371 dbSNP
rs1320476523 372 dbSNP
rs1343682165 388 dbSNP
rs895897175 391 dbSNP
rs1430342529 399 dbSNP
rs1294181880 400 dbSNP
rs1392914266 419 dbSNP
rs1222150749 422 dbSNP
rs868092865 429 dbSNP
rs779651113 436 dbSNP
rs903687451 436 dbSNP
rs575933247 449 dbSNP
rs1330522639 452 dbSNP
rs1225866445 455 dbSNP
rs1043626386 458 dbSNP
rs771042227 460 dbSNP
rs945298540 474 dbSNP
rs913553905 475 dbSNP
rs1430123181 476 dbSNP
rs749350613 483 dbSNP
rs903446032 488 dbSNP
rs1174368298 503 dbSNP
rs1252475927 506 dbSNP
rs1471014560 514 dbSNP
rs944454824 517 dbSNP
rs910333934 519 dbSNP
rs368133511 527 dbSNP
rs952210105 536 dbSNP
rs1028258630 547 dbSNP
rs972314934 550 dbSNP
rs1303035026 552 dbSNP
rs1288949590 555 dbSNP
rs1351610161 556 dbSNP
rs962638167 558 dbSNP
rs1278131370 563 dbSNP
rs1350493687 563 dbSNP
rs947599854 563 dbSNP
rs1024294392 567 dbSNP
rs1293505546 567 dbSNP
rs1377283447 571 dbSNP
rs920959528 574 dbSNP
rs1014304913 589 dbSNP
rs1182996949 591 dbSNP
rs894556890 595 dbSNP
rs1439481974 604 dbSNP
rs1179661449 606 dbSNP
rs1459327664 610 dbSNP
rs975074068 616 dbSNP
rs1184390404 618 dbSNP
rs1387350113 645 dbSNP
rs1423020914 649 dbSNP
rs1162986701 653 dbSNP
rs598959 656 dbSNP
rs1327440519 657 dbSNP
rs1335482609 659 dbSNP
rs537034763 674 dbSNP
rs912280226 683 dbSNP
rs553475653 689 dbSNP
rs775410342 698 dbSNP
rs1380078372 707 dbSNP
rs983035445 716 dbSNP
rs1274727825 737 dbSNP
rs1043980732 739 dbSNP
rs1193947967 739 dbSNP
rs951224911 743 dbSNP
rs1442748667 747 dbSNP
rs892420146 749 dbSNP
rs1040007550 761 dbSNP
rs1442994089 766 dbSNP
rs1781871 778 dbSNP
rs7246339 779 dbSNP
rs1279702508 786 dbSNP
rs557905957 788 dbSNP
rs1374318241 790 dbSNP
rs1330391283 794 dbSNP
rs1166609963 796 dbSNP
rs969270410 801 dbSNP
rs1050160855 802 dbSNP
rs930404647 802 dbSNP
rs780794548 806 dbSNP
rs1408193383 810 dbSNP
rs1295871636 816 dbSNP
rs1336322934 819 dbSNP
rs1224651146 829 dbSNP
rs754989868 831 dbSNP
rs1269120980 833 dbSNP
rs920761430 835 dbSNP
rs537998160 836 dbSNP
rs1261015299 837 dbSNP
rs1460707881 838 dbSNP
rs1203205677 840 dbSNP
rs1262718604 850 dbSNP
rs1412770648 853 dbSNP
rs1191070152 863 dbSNP
rs972666451 866 dbSNP
rs1022959664 872 dbSNP
rs1159318480 872 dbSNP
rs1441961339 873 dbSNP
rs1378894808 876 dbSNP
rs1481049296 880 dbSNP
rs751585867 886 dbSNP
rs568960802 888 dbSNP
rs1427571225 890 dbSNP
rs895893851 898 dbSNP
rs1289046362 899 dbSNP
rs917540292 900 dbSNP
rs1380221366 901 dbSNP
rs1317007238 903 dbSNP
rs1345666165 926 dbSNP
rs1225194272 932 dbSNP
rs1281311598 933 dbSNP
rs189427913 935 dbSNP
rs1228806762 936 dbSNP
rs184676776 943 dbSNP
rs1353081919 946 dbSNP
rs958656730 948 dbSNP
rs999448198 949 dbSNP
rs1490538978 952 dbSNP
rs1202168527 955 dbSNP
rs1267424437 956 dbSNP
rs566791876 964 dbSNP
rs192140993 965 dbSNP
rs1365973234 968 dbSNP
rs533176028 981 dbSNP
rs1451174453 983 dbSNP
rs1157637122 987 dbSNP
rs1365596424 990 dbSNP
rs903374968 1005 dbSNP
rs1406266970 1016 dbSNP
rs1301169127 1027 dbSNP
rs1043233735 1028 dbSNP
rs187221407 1029 dbSNP
rs1308337935 1040 dbSNP
rs878915331 1046 dbSNP
rs796083763 1052 dbSNP
rs550667355 1053 dbSNP
rs1040226608 1054 dbSNP
rs1285611068 1061 dbSNP
rs865843302 1067 dbSNP
rs1314990863 1068 dbSNP
rs1360211936 1068 dbSNP
rs1224778962 1069 dbSNP
rs1396899380 1076 dbSNP
rs1445943729 1076 dbSNP
rs1339908537 1085 dbSNP
rs900047776 1086 dbSNP
rs1253014690 1088 dbSNP
rs1417717555 1090 dbSNP
rs531084796 1091 dbSNP
rs566087555 1093 dbSNP
rs1358839893 1095 dbSNP
rs562136934 1096 dbSNP
rs1426202353 1097 dbSNP
rs1008790264 1107 dbSNP
rs1158488178 1109 dbSNP
rs888756510 1111 dbSNP
rs1364471283 1114 dbSNP
rs766395338 1122 dbSNP
rs1050545382 1123 dbSNP
rs1370848859 1124 dbSNP
rs1390640407 1127 dbSNP
rs943690137 1128 dbSNP
rs542447610 1130 dbSNP
rs1383771687 1140 dbSNP
rs1248519031 1141 dbSNP
rs28688205 1141 dbSNP
rs1046837128 1142 dbSNP
rs1036526141 1148 dbSNP
rs929704843 1155 dbSNP
rs1479839374 1156 dbSNP
rs749943898 1160 dbSNP
rs373113613 1163 dbSNP
rs919795426 1173 dbSNP
rs866785976 1174 dbSNP
rs2992091 1178 dbSNP
rs1446067499 1180 dbSNP
rs1195198784 1190 dbSNP
rs917425836 1193 dbSNP
rs1384019698 1195 dbSNP
rs764943955 1197 dbSNP
rs1428621576 1198 dbSNP
rs1284783191 1199 dbSNP
rs1352663647 1202 dbSNP
rs916462303 1204 dbSNP
rs1337135232 1215 dbSNP
rs991909987 1225 dbSNP
rs1408113735 1229 dbSNP
rs1454722378 1233 dbSNP
rs958972062 1238 dbSNP
rs761310989 1239 dbSNP
rs1215269630 1241 dbSNP
rs1297862166 1241 dbSNP
rs775942523 1241 dbSNP
rs750000083 1246 dbSNP
rs927259783 1252 dbSNP
rs145809204 1255 dbSNP
rs998976586 1265 dbSNP
rs967446361 1267 dbSNP
rs1486014027 1269 dbSNP
rs764854684 1271 dbSNP
rs1021805935 1272 dbSNP
rs968821997 1273 dbSNP
rs1278976427 1275 dbSNP
rs1401914489 1280 dbSNP
rs1427848734 1295 dbSNP
rs1011718913 1306 dbSNP
rs1455701409 1307 dbSNP
rs1010320627 1316 dbSNP
rs900098681 1318 dbSNP
rs1334918517 1328 dbSNP
rs577724511 1349 dbSNP
rs1431806931 1351 dbSNP
rs141944629 1360 dbSNP
rs1360036617 1361 dbSNP
rs767736969 1365 dbSNP
rs890828156 1372 dbSNP
rs1326052194 1373 dbSNP
rs1222032342 1376 dbSNP
rs1278421310 1377 dbSNP
rs1405357022 1384 dbSNP
rs1420844432 1389 dbSNP
rs1047164004 1392 dbSNP
rs1487685311 1393 dbSNP
rs1476523852 1395 dbSNP
rs1262053949 1403 dbSNP
rs1199648424 1405 dbSNP
rs1270997230 1407 dbSNP
rs1008757800 1412 dbSNP
rs929782996 1424 dbSNP
rs543970079 1426 dbSNP
rs1161558508 1428 dbSNP
rs144961826 1431 dbSNP
rs555254264 1432 dbSNP
rs898840520 1445 dbSNP
rs1347916264 1450 dbSNP
rs756952528 1457 dbSNP
rs940440401 1460 dbSNP
rs535666875 1461 dbSNP
rs566625490 1465 dbSNP
rs947859255 1466 dbSNP
rs183369901 1478 dbSNP
rs1057342513 1482 dbSNP
rs371217744 1486 dbSNP
rs12984321 1488 dbSNP
rs1293374568 1496 dbSNP
rs1308070586 1499 dbSNP
rs1233175572 1505 dbSNP
rs937572952 1514 dbSNP
rs927568033 1529 dbSNP
rs979044007 1535 dbSNP
rs1220556934 1548 dbSNP
rs992112198 1552 dbSNP
rs539404141 1553 dbSNP
rs928685396 1557 dbSNP
rs1323498320 1561 dbSNP
rs1355431707 1564 dbSNP
rs774890894 1564 dbSNP
rs1220073562 1566 dbSNP
rs1375661206 1568 dbSNP
rs1369987595 1574 dbSNP
rs1292218551 1580 dbSNP
rs967464192 1581 dbSNP
rs570513048 1596 dbSNP
rs1021689982 1602 dbSNP
rs1355639522 1618 dbSNP
rs1011771002 1623 dbSNP
rs771418559 1625 dbSNP
rs964230307 1633 dbSNP
rs1273654756 1639 dbSNP
rs965465675 1658 dbSNP
rs550605952 1661 dbSNP
rs1333901817 1662 dbSNP
rs1202157085 1668 dbSNP
rs530898624 1676 dbSNP
rs1439315367 1677 dbSNP
rs1184450318 1678 dbSNP
rs1387109709 1681 dbSNP
rs1422348731 1682 dbSNP
rs1176490641 1685 dbSNP
rs891370977 1686 dbSNP
rs8112775 1687 dbSNP
rs1329706530 1696 dbSNP
rs1400105654 1706 dbSNP
rs1452827336 1707 dbSNP
rs1190410217 1713 dbSNP
rs1379877187 1720 dbSNP
rs993758446 1723 dbSNP
rs150315400 1724 dbSNP
rs1341372397 1730 dbSNP
rs1212805337 1739 dbSNP
rs111651784 1749 dbSNP
rs994768435 1756 dbSNP
rs1196631353 1757 dbSNP
rs489845 1762 dbSNP
rs1245238326 1764 dbSNP
rs895012176 1767 dbSNP
rs1186901043 1768 dbSNP
rs1056692340 1772 dbSNP
rs192594092 1773 dbSNP
rs939321449 1774 dbSNP
rs923820672 1782 dbSNP
rs1476670270 1789 dbSNP
rs1234050794 1790 dbSNP
rs1014619952 1801 dbSNP
rs532903506 1805 dbSNP
rs946006985 1806 dbSNP
rs564062365 1824 dbSNP
rs1318401347 1828 dbSNP
rs2928190 1828 dbSNP
rs1428487671 1829 dbSNP
rs11542488 1839 dbSNP
rs767976992 1842 dbSNP
rs964120057 1845 dbSNP
rs1323944602 1846 dbSNP
rs188210297 1859 dbSNP
rs1343117198 1861 dbSNP
rs1400189065 1861 dbSNP
rs1043675483 1864 dbSNP
rs987336368 1881 dbSNP
rs947673976 1891 dbSNP
rs1302985176 1892 dbSNP
rs1467068376 1901 dbSNP
rs488125 1903 dbSNP
rs988799095 1904 dbSNP
rs1202027383 1918 dbSNP
rs1465174466 1929 dbSNP
rs377351660 1942 dbSNP
rs487991 1945 dbSNP
rs151184464 1963 dbSNP
rs1417357966 1971 dbSNP
rs1297090002 1977 dbSNP
rs898188401 1992 dbSNP
rs1346042871 1996 dbSNP
rs1016541405 1997 dbSNP
rs1011985728 1998 dbSNP
rs1439082219 1999 dbSNP
rs1261551440 2006 dbSNP
rs894884268 2016 dbSNP
rs953295367 2017 dbSNP
rs1243608888 2025 dbSNP
rs1056302243 2034 dbSNP
rs1028844221 2035 dbSNP
rs1285474370 2046 dbSNP
rs1484249680 2046 dbSNP
rs973700840 2047 dbSNP
rs1202232573 2048 dbSNP
rs1254520310 2049 dbSNP
rs200190623 2051 dbSNP
rs142936365 2054 dbSNP
rs138452031 2056 dbSNP
rs1157512213 2057 dbSNP
rs3051927 2057 dbSNP
rs79406182 2057 dbSNP
rs552799540 2058 dbSNP
rs939153992 2059 dbSNP
rs1291727238 2062 dbSNP
rs1288669411 2070 dbSNP
rs902447828 2072 dbSNP
rs1042351406 2073 dbSNP
rs1391789892 2075 dbSNP
rs1308928293 2092 dbSNP
rs1379367495 2096 dbSNP
rs1035399025 2099 dbSNP
rs111928703 2105 dbSNP
rs1001300529 2107 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions Hela
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1048187. RNA binding protein: AGO2. Condition:Hela_AGO2_CLIP_control ...

- Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al., 2013, Cell.

Article - Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al.
- Cell, 2013
The induction of pluripotency or trans-differentiation of one cell type to another can be accomplished with cell-lineage-specific transcription factors. Here, we report that repression of a single RNA binding polypyrimidine-tract-binding (PTB) protein, which occurs during normal brain development via the action of miR-124, is sufficient to induce trans-differentiation of fibroblasts into functional neurons. Besides its traditional role in regulated splicing, we show that PTB has a previously undocumented function in the regulation of microRNA functions, suppressing or enhancing microRNA targeting by competitive binding on target mRNA or altering local RNA secondary structure. A key event during neuronal induction is the relief of PTB-mediated blockage of microRNA action on multiple components of the REST complex, thereby derepressing a large array of neuronal genes, including miR-124 and multiple neuronal-specific transcription factors, in nonneuronal cells. This converts a negative feedback loop to a positive one to elicit cellular reprogramming to the neuronal lineage.
LinkOut: [PMID: 23313552]
CLIP-seq Support 1 for dataset GSM1048187
Method / RBP HITS-CLIP / AGO2
Cell line / Condition Hela / Hela_AGO2_CLIP_control
Location of target site ENST00000356929.3 | 3UTR | UGACCCACCCGCCUCGACCUCCC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23313552 / GSE42701
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
THCA -0.139 0.38 -0.143 0.38 7 Click to see details
THCA -0.139 0.38 -0.143 0.38 7 Click to see details
THCA -0.139 0.38 -0.143 0.38 7 Click to see details
THCA -0.139 0.38 -0.143 0.38 7 Click to see details
THCA -0.139 0.38 -0.143 0.38 7 Click to see details
THCA -0.139 0.38 -0.143 0.38 7 Click to see details
102 hsa-miR-3622b-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT076713 NUFIP2 NUFIP2, FMR1 interacting protein 2 2 2
MIRT080212 PRKACB protein kinase cAMP-activated catalytic subunit beta 2 2
MIRT081398 GTPBP3 GTP binding protein 3, mitochondrial 2 2
MIRT107158 ZBTB43 zinc finger and BTB domain containing 43 2 2
MIRT254071 BACH1 BTB domain and CNC homolog 1 2 2
MIRT409790 FOXO3 forkhead box O3 2 2
MIRT448679 MAPK9 mitogen-activated protein kinase 9 2 2
MIRT450206 ABHD15 abhydrolase domain containing 15 2 2
MIRT486621 PDK3 pyruvate dehydrogenase kinase 3 2 2
MIRT489267 TTLL1 tubulin tyrosine ligase like 1 2 2
MIRT493117 MKNK2 MAP kinase interacting serine/threonine kinase 2 2 4
MIRT494570 BAK1 BCL2 antagonist/killer 1 2 2
MIRT497395 RALY RALY heterogeneous nuclear ribonucleoprotein 2 2
MIRT504900 CCDC86 coiled-coil domain containing 86 2 2
MIRT505192 USP46 ubiquitin specific peptidase 46 2 4
MIRT506522 MSANTD4 Myb/SANT DNA binding domain containing 4 with coiled-coils 2 6
MIRT508162 ABCC5 ATP binding cassette subfamily C member 5 2 8
MIRT508545 PARVG parvin gamma 2 4
MIRT509850 BIRC5 baculoviral IAP repeat containing 5 2 6
MIRT510088 PPWD1 peptidylprolyl isomerase domain and WD repeat containing 1 2 8
MIRT512094 CRK CRK proto-oncogene, adaptor protein 2 4
MIRT515381 RPL7 ribosomal protein L7 2 2
MIRT519176 SCO1 SCO1, cytochrome c oxidase assembly protein 2 2
MIRT519964 ZCCHC8 zinc finger CCHC-type containing 8 2 2
MIRT522292 NKAP NFKB activating protein 2 2
MIRT523160 HMGB2 high mobility group box 2 2 4
MIRT525314 FANCA Fanconi anemia complementation group A 2 2
MIRT528194 PLEKHM2 pleckstrin homology and RUN domain containing M2 2 2
MIRT532885 ZNF451 zinc finger protein 451 2 2
MIRT538209 CYR61 cysteine rich angiogenic inducer 61 2 2
MIRT539497 ACTN4 actinin alpha 4 2 2
MIRT554600 RRAGC Ras related GTP binding C 2 2
MIRT562444 DCTN6 dynactin subunit 6 2 2
MIRT562748 AOC3 amine oxidase, copper containing 3 2 2
MIRT565798 SEC14L5 SEC14 like lipid binding 5 2 2
MIRT565838 SCML2 Scm polycomb group protein like 2 2 2
MIRT566072 RCC2 regulator of chromosome condensation 2 2 2
MIRT566104 RBPJ recombination signal binding protein for immunoglobulin kappa J region 2 2
MIRT572407 MRPS14 mitochondrial ribosomal protein S14 2 2
MIRT576198 Vsig2 V-set and immunoglobulin domain containing 2 2 2
MIRT576313 Acbd7 acyl-Coenzyme A binding domain containing 7 2 2
MIRT576651 Mill2 MHC I like leukocyte 2 1 1
MIRT576859 Socs6 suppressor of cytokine signaling 6 2 2
MIRT606819 BICD2 BICD cargo adaptor 2 2 2
MIRT610738 NUDT16 nudix hydrolase 16 2 4
MIRT614798 RORA RAR related orphan receptor A 2 2
MIRT619006 NTMT1 N-terminal Xaa-Pro-Lys N-methyltransferase 1 2 2
MIRT619420 NOS1AP nitric oxide synthase 1 adaptor protein 2 2
MIRT620405 MYO1H myosin IH 2 2
MIRT624869 ABHD13 abhydrolase domain containing 13 2 2
MIRT633527 ZFP30 ZFP30 zinc finger protein 2 2
MIRT633927 DNAH9 dynein axonemal heavy chain 9 2 2
MIRT636611 CLIC5 chloride intracellular channel 5 2 2
MIRT640616 MIOX myo-inositol oxygenase 2 2
MIRT642605 C14orf180 chromosome 14 open reading frame 180 2 2
MIRT644624 SRSF2 serine and arginine rich splicing factor 2 2 2
MIRT655113 PHLDA3 pleckstrin homology like domain family A member 3 2 2
MIRT658976 DNAJB5 DnaJ heat shock protein family (Hsp40) member B5 2 4
MIRT661495 CHMP1B charged multivesicular body protein 1B 2 2
MIRT662996 TMEM59 transmembrane protein 59 2 2
MIRT663075 SFR1 SWI5 dependent homologous recombination repair protein 1 2 2
MIRT665405 WEE1 WEE1 G2 checkpoint kinase 2 2
MIRT666106 SSR1 signal sequence receptor subunit 1 2 2
MIRT669562 ALDOA aldolase, fructose-bisphosphate A 2 2
MIRT670070 ZNF783 zinc finger family member 783 2 2
MIRT671192 ZNF891 zinc finger protein 891 2 2
MIRT675361 KLHL26 kelch like family member 26 2 2
MIRT678857 LINC00598 long intergenic non-protein coding RNA 598 2 2
MIRT679443 C19orf52 translocase of inner mitochondrial membrane 29 2 2
MIRT684163 ALDH1B1 aldehyde dehydrogenase 1 family member B1 2 2
MIRT684543 ZNF460 zinc finger protein 460 2 2
MIRT684674 SLC2A11 solute carrier family 2 member 11 2 2
MIRT684971 MINOS1 mitochondrial inner membrane organizing system 1 2 2
MIRT686006 NEK4 NIMA related kinase 4 2 2
MIRT687758 KIAA1328 KIAA1328 2 2
MIRT688961 ATXN3 ataxin 3 2 2
MIRT689409 UQCR11 ubiquinol-cytochrome c reductase, complex III subunit XI 2 2
MIRT690001 MMP17 matrix metallopeptidase 17 2 2
MIRT690165 ELP3 elongator acetyltransferase complex subunit 3 2 2
MIRT690202 C5orf45 MRN complex interacting protein 2 2
MIRT690477 ZNF33A zinc finger protein 33A 2 2
MIRT690566 MICA MHC class I polypeptide-related sequence A 2 2
MIRT692160 C10orf111 chromosome 10 open reading frame 111 2 2
MIRT693430 PLGLB2 plasminogen-like B2 2 2
MIRT693547 ZNF708 zinc finger protein 708 2 2
MIRT693697 PLGLB1 plasminogen-like B1 2 2
MIRT695006 HSPA6 heat shock protein family A (Hsp70) member 6 2 2
MIRT698525 TFRC transferrin receptor 2 2
MIRT699574 SIKE1 suppressor of IKBKE 1 2 2
MIRT703446 FYTTD1 forty-two-three domain containing 1 2 2
MIRT704397 CTSS cathepsin S 2 2
MIRT704485 CPT1A carnitine palmitoyltransferase 1A 2 2
MIRT709822 STPG1 sperm tail PG-rich repeat containing 1 2 2
MIRT710859 COQ7 coenzyme Q7, hydroxylase 2 2
MIRT711893 INSIG2 insulin induced gene 2 2 2
MIRT713796 CPLX2 complexin 2 2 2
MIRT718800 C1GALT1C1 C1GALT1 specific chaperone 1 2 2
MIRT719501 SEC24B SEC24 homolog B, COPII coat complex component 2 2
MIRT719722 PDE6B phosphodiesterase 6B 2 2
MIRT722204 URM1 ubiquitin related modifier 1 2 2
MIRT723523 CLPTM1L CLPTM1 like 2 2
MIRT725471 GRAP2 GRB2-related adaptor protein 2 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-3622b-3p Platinum 23939 sensitive tissue
hsa-miR-3622b-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-3622b-3p Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (1500 ng/ml)
hsa-miR-3622b-3p Paclitaxel/Docetaxel/Vinorelbine/Doxorubicin/Etoposide resistant cell line (Bads-200)

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