miRTarBase - #MIRT693737


—
pre-miRNA Information
pre-miRNA hsa-mir-378f   
Genomic Coordinates chr1: 23929070 - 23929147
Description Homo sapiens miR-378f stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-378f
Sequence 52| ACUGGACUUGGAGCCAGAAG |71
Evidence Experimental
Experiments Illumina
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 18 1 + 23929138 29233923 MiREDiBase
A-to-I 19 1 + 23929139 29233923 MiREDiBase
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol ACACA   
Synonyms ACAC, ACACAD, ACC, ACC1, ACCA
Description acetyl-CoA carboxylase alpha
Transcript NM_198834   
Other Transcripts NM_198836 , NM_198837 , NM_198838 , NM_198839   
Expression
Putative miRNA Targets on ACACA
3'UTR of ACACA
(miRNA target sites are highlighted)		 
>ACACA|NM_198834|3'UTR
   1 GAAGAGCTTCCTGCCTGTCCCTGCCCTGTCTCTGGAGAAAAGGGCTAGAGCTGCCTTTTACAACTGTAACCACTGTAATG
  81 AGAAGGCACAGGAGACCCAGCACTGGAGTCAAATGGCATTTTACTTCCTCTCGTTTCAGGTTATGCATGACATCCTGGGA
 161 TGTAAGATCACAGAATCCCCCTCCAGCCCACCAGTCACACCTACCCCATTCAGTATTTATTACCCTGGCCAGGCCTAGTC
 241 CTCCACTCCCTGCACAGGACTGAGAAGGCAATGAAAGGTACAAACATGTACCATGAGGTCTTACTAACCAAAGTAGGGCT
 321 GCCCCTCCTGTCCTGACAGCCCCTTGGCCTCCCAGCATGGGGAAGCGTGAGGAGTTGCCCAGCAGTGAGCAGCCCCCCTC
 401 ACTCCTGGCCCCATGAGCCGCAGCCACAGGCAGCAGAGGAGGGCTAAGGAGAGGAGGAAGCCTCAAGTCCATTGTTTATT
 481 ACCCCGACTCTTAGCCCAGCACACAGTAGGCACTGGAGAGGAATGATTCCCAGTTTAACCACACTACGGTACCTTTTATG
 561 AAGAAAAATTAGAGCATAAAATCTACTACAAGCTCCATAGGAACTCAAAGATGAGGGCAAAACTGTGAGCCAAGAAGCAG
 641 AGAAAGAAAATAGAACCAGTTATTCTTGATTTAGGGGACCTCAACCTTGGGTTCAGTCTCTGAGGACAAAGGGAAAGGTA
 721 GTTGTTGGCCTGCCTCTCGCCTGCACGTCACTGCTGGACTAGCTGTCGCATGTGGCTGGGAGCTGCAAGGCCAGTGCTTG
 801 AGGGGCCCCAGCAGTTCCACAGGTGGTGAAGCCTGAGTTGGCAGAGGAGGAGCCAGAAGAGAACTGCCCTTTCTGCACTG
 881 GTGGAAACTAGTTATTTATGCCATGTGGAGAGCCAGTGAGATAGATAGATAGTCTGTTTGTTTTGAGGACTTGGAAAGTT
 961 GTTCCTATGAAGCCTGGAGCTTGGATGGTTTTGAGAGGTTAATGGTGCCTCCACACTCACTCTTCCCTAGTTCCAGGATT
1041 ACTGTCCTAGCAGCTAACGGTTCTACTCTCTTCCCCAGAGTGTAGACAGGCAGCAGGTCTCCCCACAGCTCTGAAAGGAC
1121 CCTGGTGACAGCTACACCCTCAGCACCAGGAGCTGGCCTTCCTGATGAGGGAGGCTTCCAGGAAACACAGAATCCACATG
1201 ACCTTAAGATTATTTACAACTCAGTCATGGTGCTGCTGTCCTCCAGGCTTACTGGCCCCTCCTGACTGGCATCAGGGGCT
1281 TCCTCAGGTGGTGGAGAGAGTTTACTTTCAACAACTAGTTTATTCAAGAAAAGAACTTACTGATTCCTCTGTTCCTAAAG
1361 CAAGAGTGGCAGGTGATCAGGGCTGGTGTAGCATCCGGTTCCTTTAGTGCAGCTAACTGCATTTGTCACTGATGACCAAG
1441 GAGGAAATCACTAAGACATTTGAGAAGCAGTGGTATGAACGTTCTTGGACAAGCCACAGTTCTGAGCCTTAACCCTGTAG
1521 TTTGCACACAAGAACGAGCTCCACCTCCCCTTCTTCAGGAGGAATCTGTGCGGATAGATTGGCTGGACTTTTCAATGGTT
1601 CTGGGTTGCAGGTGGGCACTGTATGGCTGGGTATGGAGCGGACAGCCCCCAGGAGTCAGAGCCTCAGCCCGGCTGCCCTG
1681 GTGGAAGGTACAGGTGTTCAGCACCTTCAGAAAAGGGCATAAAGTGGTGGGGGACAATTCTCAGTCCAGGAAAATGCATT
1761 GACCATTGCTGGCTATTTGCTTACCTAGTAAGAATTGGATTCATTTTTGACCAGATTATTCTTCTATGCTTTTTTGCAAT
1841 AAATCAAATCCCACATATCTACAAGTGGTATGAAGTCCTGCACCCCCCAGGAGGCCTGTCCAGGCATGTCTTCAGAGGCA
1921 GGGTGGGTTACACTCATTTACCTCCCCTCTCCCCACCAAATTATGACACAAACGAGTATGTTTCCTCTCTAGAACCCTGT
2001 AATGCCTCCTCCCCCATCCCCAGAGCTCCTTACTGTAGGTCTTACCCTGGACAAGGATTTTTTCAAGTTGGAGGCACAGA
2081 ACATGAGCAATCTGACATTCCCACAGCCCCTCAAACATGCAAGGCTACTAAGGCAGGAGGAGTATAAATGATGGATATTG
2161 ACCAAGACCTGCTTGGACGGAGACCGCCATATTATCTGTTCTCTTCGTTCACAAAACAGCCTTCACTTGTCTCAGAATTT
2241 GATGGACACATACTGTGATGAGCAGGAGCTTCAGATGCACTCTTTACACATTTTGTTGAAATAAACCTCTACATTTGTAG
2321 AAGAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' gaagaccGAGGUUCAGGUCa 5'
                 :||: ||||||| 
Target 5' gggacaaTTCTCAGTCCAGg 3'
 1731 - 1750 149.00 -13.80
2 
miRNA  3' gaagacCGAGGUUCAGGUca 5'
                || :||||||||  
Target 5' gaggaaGCCTCAAGTCCAtt 3'
 454 - 473 138.00 -14.00
3 
miRNA  3' gaaGAC---CGAGGUUCAGGUCa 5'
             |||   ||| |||| |||| 
Target 5' tggCTGGGAGCTGCAAGGCCAGt 3'
 773 - 795 133.00 -19.40
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1368630960 1 dbSNP
rs372217087 8 dbSNP
rs368526859 19 dbSNP
rs1228870482 21 dbSNP
rs748601714 23 dbSNP
rs969982926 27 dbSNP
rs781130249 30 dbSNP
rs1178776238 31 dbSNP
rs1426131143 32 dbSNP
rs1438877673 35 dbSNP
rs1478170520 35 dbSNP
rs1253334520 42 dbSNP
rs1170121570 43 dbSNP
rs772052399 47 dbSNP
rs1488372925 48 dbSNP
rs1371792970 55 dbSNP
rs944971901 59 dbSNP
rs1173450241 63 dbSNP
rs1349962455 66 dbSNP
rs1401932590 71 dbSNP
rs3197958 72 dbSNP
rs1313511468 75 dbSNP
rs201465790 79 dbSNP
rs3214149 79 dbSNP
rs2285654 80 dbSNP
rs780241087 80 dbSNP
rs139313088 81 dbSNP
rs1342045769 83 dbSNP
rs1400028750 85 dbSNP
rs779304055 90 dbSNP
rs1305627798 93 dbSNP
rs1225016142 100 dbSNP
rs569166182 101 dbSNP
rs138971831 104 dbSNP
rs755267058 107 dbSNP
rs756703260 108 dbSNP
rs555455642 117 dbSNP
rs1385952609 118 dbSNP
rs1391190609 125 dbSNP
rs541868192 126 dbSNP
rs185993557 127 dbSNP
rs751020783 133 dbSNP
rs763781086 144 dbSNP
rs778415830 145 dbSNP
rs1366010655 147 dbSNP
rs1488750833 150 dbSNP
rs1197391083 154 dbSNP
rs775328483 158 dbSNP
rs973849357 159 dbSNP
rs1202123053 164 dbSNP
rs1200201371 169 dbSNP
rs1487420593 171 dbSNP
rs1285611414 177 dbSNP
rs962436929 179 dbSNP
rs1160850518 181 dbSNP
rs1352949288 185 dbSNP
rs1254102629 186 dbSNP
rs1232432797 191 dbSNP
rs1346136732 192 dbSNP
rs1015695615 195 dbSNP
rs1397957673 198 dbSNP
rs1339401955 200 dbSNP
rs1419934692 202 dbSNP
rs1287722982 206 dbSNP
rs765000699 208 dbSNP
rs759311736 214 dbSNP
rs1399443301 224 dbSNP
rs1171559355 227 dbSNP
rs1465970723 229 dbSNP
rs1430679163 233 dbSNP
rs921138295 234 dbSNP
rs1477057198 238 dbSNP
rs756875275 241 dbSNP
rs1354596317 243 dbSNP
rs753432515 244 dbSNP
rs1259240091 246 dbSNP
rs1489489714 248 dbSNP
rs770857212 252 dbSNP
rs1191899480 254 dbSNP
rs1449022156 255 dbSNP
rs1453152667 263 dbSNP
rs79037131 267 dbSNP
rs1199992293 272 dbSNP
rs908636473 274 dbSNP
rs1034902251 278 dbSNP
rs1344137197 283 dbSNP
rs1324145349 286 dbSNP
rs1264962193 288 dbSNP
rs1216518369 291 dbSNP
rs1317084957 293 dbSNP
rs1157908948 296 dbSNP
rs145093664 298 dbSNP
rs1458975369 302 dbSNP
rs1432457498 303 dbSNP
rs1393584351 304 dbSNP
rs1227282260 305 dbSNP
rs960709265 308 dbSNP
rs1311103820 313 dbSNP
rs181048852 314 dbSNP
rs189795985 319 dbSNP
rs1432536798 324 dbSNP
rs1383756938 329 dbSNP
rs981467629 332 dbSNP
rs969574051 341 dbSNP
rs1459015960 342 dbSNP
rs1022849301 344 dbSNP
rs1366133893 346 dbSNP
rs1239390714 357 dbSNP
rs1011081334 359 dbSNP
rs1175896537 361 dbSNP
rs957084779 365 dbSNP
rs1163519326 375 dbSNP
rs1425218761 377 dbSNP
rs141429307 378 dbSNP
rs1416537009 378 dbSNP
rs1333276718 389 dbSNP
rs1401008515 391 dbSNP
rs568215321 398 dbSNP
rs375404463 399 dbSNP
rs548245041 399 dbSNP
rs1250362613 400 dbSNP
rs1010968630 408 dbSNP
rs892527265 413 dbSNP
rs1052877457 416 dbSNP
rs1008860250 419 dbSNP
rs1038573822 420 dbSNP
rs1437782678 420 dbSNP
rs890449084 421 dbSNP
rs537939001 424 dbSNP
rs1188201792 435 dbSNP
rs1256445205 436 dbSNP
rs1473928737 437 dbSNP
rs932206938 440 dbSNP
rs1172223868 444 dbSNP
rs1409310314 449 dbSNP
rs1424207013 449 dbSNP
rs1167987880 458 dbSNP
rs1047164657 460 dbSNP
rs920783841 467 dbSNP
rs756170515 472 dbSNP
rs1312469249 476 dbSNP
rs1353852310 477 dbSNP
rs751985413 485 dbSNP
rs1339224518 486 dbSNP
rs927986869 486 dbSNP
rs1291061338 506 dbSNP
rs752652228 507 dbSNP
rs980801798 518 dbSNP
rs941118742 528 dbSNP
rs1281416194 539 dbSNP
rs1313142376 541 dbSNP
rs1210662408 542 dbSNP
rs569265548 547 dbSNP
rs982860655 548 dbSNP
rs1195132951 549 dbSNP
rs960444979 553 dbSNP
rs552285895 556 dbSNP
rs1342781569 563 dbSNP
rs927613686 567 dbSNP
rs1184704478 569 dbSNP
rs1299599088 570 dbSNP
rs1414801884 586 dbSNP
rs948263517 587 dbSNP
rs1373824752 588 dbSNP
rs980685290 589 dbSNP
rs1325589055 590 dbSNP
rs1323812964 595 dbSNP
rs1325913199 597 dbSNP
rs969260410 600 dbSNP
rs1428798198 609 dbSNP
rs1388090312 612 dbSNP
rs1368946697 613 dbSNP
rs1233973529 615 dbSNP
rs1301713332 637 dbSNP
rs184202779 639 dbSNP
rs1301983502 640 dbSNP
rs1430990575 641 dbSNP
rs1218325697 642 dbSNP
rs1284602869 657 dbSNP
rs1445888687 660 dbSNP
rs1392539873 668 dbSNP
rs532393564 672 dbSNP
rs1248335443 678 dbSNP
rs560729222 689 dbSNP
rs181439255 690 dbSNP
rs1454679124 692 dbSNP
rs759242838 695 dbSNP
rs1167204891 696 dbSNP
rs1192702063 702 dbSNP
rs1475307871 709 dbSNP
rs1441371273 710 dbSNP
rs530288541 711 dbSNP
rs12451927 713 dbSNP
rs541943361 715 dbSNP
rs1325648248 720 dbSNP
rs1031123945 723 dbSNP
rs766517824 728 dbSNP
rs1379569448 734 dbSNP
rs890489574 737 dbSNP
rs189165169 738 dbSNP
rs996447233 739 dbSNP
rs899383834 740 dbSNP
rs7350920 741 dbSNP
rs1037878985 744 dbSNP
rs940832649 746 dbSNP
rs763119120 747 dbSNP
rs1291408261 757 dbSNP
rs1468814255 765 dbSNP
rs1029709337 767 dbSNP
rs908035890 768 dbSNP
rs1182315874 769 dbSNP
rs1046846154 774 dbSNP
rs1165022733 782 dbSNP
rs1418654028 790 dbSNP
rs1461049776 793 dbSNP
rs1275204402 803 dbSNP
rs1324435444 805 dbSNP
rs1403149284 806 dbSNP
rs1235043775 809 dbSNP
rs939086968 814 dbSNP
rs1328637212 822 dbSNP
rs1334736214 823 dbSNP
rs1439586264 830 dbSNP
rs927658918 832 dbSNP
rs7350918 833 dbSNP
rs996530981 839 dbSNP
rs1409924293 849 dbSNP
rs746334489 853 dbSNP
rs1371822493 861 dbSNP
rs146623741 864 dbSNP
rs969290079 866 dbSNP
rs1306727370 870 dbSNP
rs1196095060 875 dbSNP
rs1249576404 876 dbSNP
rs1016821163 877 dbSNP
rs1005330529 878 dbSNP
rs562548317 887 dbSNP
rs1474909637 904 dbSNP
rs915125720 906 dbSNP
rs1047125681 909 dbSNP
rs1462947059 910 dbSNP
rs1167642427 913 dbSNP
rs3177098 918 dbSNP
rs989354485 922 dbSNP
rs1394766461 923 dbSNP
rs1398221669 923 dbSNP
rs1403431555 926 dbSNP
rs1174677908 928 dbSNP
rs1491278006 931 dbSNP
rs1491356757 932 dbSNP
rs539123061 932 dbSNP
rs540396270 933 dbSNP
rs771292720 933 dbSNP
rs939402300 933 dbSNP
rs1228052958 935 dbSNP
rs956600186 938 dbSNP
rs1337168880 944 dbSNP
rs146529350 944 dbSNP
rs1202017124 954 dbSNP
rs1281248153 961 dbSNP
rs1485486826 962 dbSNP
rs1185809552 964 dbSNP
rs915465100 965 dbSNP
rs773299099 967 dbSNP
rs368239619 972 dbSNP
rs1009005897 980 dbSNP
rs1467877738 985 dbSNP
rs35451821 993 dbSNP
rs924140564 994 dbSNP
rs954933527 1003 dbSNP
rs112276413 1015 dbSNP
rs1433733059 1018 dbSNP
rs150058866 1020 dbSNP
rs1437158850 1023 dbSNP
rs899416231 1033 dbSNP
rs769838346 1042 dbSNP
rs1016568556 1053 dbSNP
rs1201937233 1058 dbSNP
rs1324642651 1059 dbSNP
rs1236174081 1066 dbSNP
rs1303881218 1068 dbSNP
rs1347351040 1069 dbSNP
rs1208982098 1074 dbSNP
rs1288507174 1078 dbSNP
rs879681227 1078 dbSNP
rs1486215167 1085 dbSNP
rs1204676460 1095 dbSNP
rs1321085635 1101 dbSNP
rs1260193032 1103 dbSNP
rs767461852 1104 dbSNP
rs1435453940 1106 dbSNP
rs1194596706 1121 dbSNP
rs1394846751 1124 dbSNP
rs1262151489 1135 dbSNP
rs1029435667 1137 dbSNP
rs1171328477 1142 dbSNP
rs1346651967 1161 dbSNP
rs8073540 1166 dbSNP
rs886640471 1178 dbSNP
rs776998966 1180 dbSNP
rs1382613744 1190 dbSNP
rs1443025987 1190 dbSNP
rs1057479453 1193 dbSNP
rs963777156 1196 dbSNP
rs879833141 1203 dbSNP
rs1016790030 1210 dbSNP
rs939134698 1211 dbSNP
rs1309392617 1216 dbSNP
rs1238367921 1224 dbSNP
rs201930457 1228 dbSNP
rs867617118 1230 dbSNP
rs1442208009 1231 dbSNP
rs887032585 1233 dbSNP
rs1252969355 1241 dbSNP
rs140469577 1253 dbSNP
rs538385113 1256 dbSNP
rs1157660355 1259 dbSNP
rs866489252 1266 dbSNP
rs569242922 1269 dbSNP
rs552551327 1272 dbSNP
rs1462619416 1273 dbSNP
rs1165517944 1288 dbSNP
rs1393705851 1291 dbSNP
rs1438379572 1295 dbSNP
rs538611105 1295 dbSNP
rs1045180661 1297 dbSNP
rs1044718661 1298 dbSNP
rs948029520 1300 dbSNP
rs1160189563 1301 dbSNP
rs1234032490 1301 dbSNP
rs893852731 1301 dbSNP
rs567194123 1303 dbSNP
rs1206985232 1316 dbSNP
rs1409933426 1317 dbSNP
rs1480542837 1329 dbSNP
rs1176259353 1330 dbSNP
rs200592367 1336 dbSNP
rs1475887472 1341 dbSNP
rs1469607440 1342 dbSNP
rs947762986 1368 dbSNP
rs977642483 1374 dbSNP
rs914900093 1378 dbSNP
rs1417025738 1386 dbSNP
rs1189480448 1387 dbSNP
rs967269324 1387 dbSNP
rs924192715 1392 dbSNP
rs151241736 1396 dbSNP
rs1354895007 1397 dbSNP
rs1262217957 1403 dbSNP
rs1209033547 1404 dbSNP
rs1021935881 1406 dbSNP
rs1357627545 1412 dbSNP
rs923814500 1417 dbSNP
rs922334148 1429 dbSNP
rs987680263 1430 dbSNP
rs1354052633 1433 dbSNP
rs758292378 1433 dbSNP
rs1274401739 1441 dbSNP
rs1307245872 1443 dbSNP
rs1202920134 1452 dbSNP
rs1222684690 1454 dbSNP
rs1271978830 1458 dbSNP
rs954782321 1473 dbSNP
rs530400221 1476 dbSNP
rs1356378736 1480 dbSNP
rs974823879 1481 dbSNP
rs964040129 1484 dbSNP
rs1420199726 1489 dbSNP
rs1427650772 1493 dbSNP
rs1168101270 1497 dbSNP
rs575543282 1498 dbSNP
rs983751859 1499 dbSNP
rs1321635306 1507 dbSNP
rs1373702948 1519 dbSNP
rs1016262232 1533 dbSNP
rs561493986 1535 dbSNP
rs550891438 1536 dbSNP
rs1005159252 1537 dbSNP
rs1213135794 1538 dbSNP
rs886667533 1558 dbSNP
rs1349526163 1560 dbSNP
rs1035876490 1564 dbSNP
rs1158589586 1568 dbSNP
rs1003419451 1571 dbSNP
rs1279215354 1571 dbSNP
rs906295583 1572 dbSNP
rs1242591697 1580 dbSNP
rs756994304 1595 dbSNP
rs748928006 1597 dbSNP
rs1186381115 1617 dbSNP
rs777465712 1619 dbSNP
rs1454603795 1620 dbSNP
rs1442689452 1623 dbSNP
rs893496425 1625 dbSNP
rs11557526 1629 dbSNP
rs990084281 1632 dbSNP
rs562400530 1633 dbSNP
rs1319101593 1634 dbSNP
rs1345046051 1634 dbSNP
rs935274931 1638 dbSNP
rs559250231 1639 dbSNP
rs184778331 1640 dbSNP
rs193240763 1647 dbSNP
rs767373323 1649 dbSNP
rs1214583096 1661 dbSNP
rs148735368 1670 dbSNP
rs963440149 1675 dbSNP
rs1445977844 1680 dbSNP
rs1244502599 1688 dbSNP
rs1359309182 1695 dbSNP
rs1052055098 1696 dbSNP
rs1468730119 1702 dbSNP
rs1298862720 1720 dbSNP
rs933468762 1723 dbSNP
rs1471282399 1730 dbSNP
rs1159161784 1733 dbSNP
rs371481883 1735 dbSNP
rs754880790 1742 dbSNP
rs1407330412 1749 dbSNP
rs909234859 1758 dbSNP
rs1455770271 1761 dbSNP
rs1231102571 1763 dbSNP
rs188898277 1768 dbSNP
rs574391575 1769 dbSNP
rs951005594 1779 dbSNP
rs1328941616 1783 dbSNP
rs942424686 1784 dbSNP
rs368001706 1787 dbSNP
rs1349298882 1788 dbSNP
rs1226090996 1790 dbSNP
rs1036313397 1797 dbSNP
rs147411301 1809 dbSNP
rs1335421329 1810 dbSNP
rs1212767307 1814 dbSNP
rs751339613 1818 dbSNP
rs763293140 1823 dbSNP
rs1182792109 1826 dbSNP
rs1439401378 1826 dbSNP
rs184463978 1827 dbSNP
rs1023069516 1830 dbSNP
rs34866388 1836 dbSNP
rs1190191857 1838 dbSNP
rs1419129633 1839 dbSNP
rs1461394236 1842 dbSNP
rs1162041512 1843 dbSNP
rs370259948 1847 dbSNP
rs1422717088 1850 dbSNP
rs982089875 1858 dbSNP
rs970960075 1860 dbSNP
rs1407405394 1861 dbSNP
rs1294597992 1862 dbSNP
rs1355945680 1865 dbSNP
rs575697342 1880 dbSNP
rs546639219 1885 dbSNP
rs1232589674 1886 dbSNP
rs1023433986 1889 dbSNP
rs558755823 1890 dbSNP
rs1384516219 1895 dbSNP
rs1244636575 1903 dbSNP
rs1012496374 1908 dbSNP
rs953323756 1924 dbSNP
rs539038401 1927 dbSNP
rs773300335 1942 dbSNP
rs1028988547 1951 dbSNP
rs902171512 1956 dbSNP
rs1052151763 1965 dbSNP
rs1258303512 1973 dbSNP
rs1474962179 1976 dbSNP
rs933213346 1980 dbSNP
rs921787520 1995 dbSNP
rs1032442972 1996 dbSNP
rs192491438 2001 dbSNP
rs1167726795 2002 dbSNP
rs942107133 2010 dbSNP
rs1369478433 2013 dbSNP
rs999516175 2014 dbSNP
rs902541172 2017 dbSNP
rs374105562 2024 dbSNP
rs1247989716 2025 dbSNP
rs1219592220 2026 dbSNP
rs983474431 2031 dbSNP
rs1227807908 2034 dbSNP
rs1269392272 2035 dbSNP
rs1276009235 2048 dbSNP
rs538144619 2064 dbSNP
rs1281360921 2073 dbSNP
rs1485374803 2079 dbSNP
rs1198819067 2082 dbSNP
rs1264421849 2085 dbSNP
rs1448083017 2091 dbSNP
rs74331078 2093 dbSNP
rs1207828963 2098 dbSNP
rs997742917 2102 dbSNP
rs1388692243 2103 dbSNP
rs1306137555 2104 dbSNP
rs1295284226 2114 dbSNP
rs1220103840 2118 dbSNP
rs900752297 2121 dbSNP
rs1039177015 2123 dbSNP
rs144363574 2124 dbSNP
rs1382698900 2129 dbSNP
rs928639454 2136 dbSNP
rs1371201309 2138 dbSNP
rs1308567138 2140 dbSNP
rs1236286321 2141 dbSNP
rs1304382664 2142 dbSNP
rs1311857917 2143 dbSNP
rs981683367 2145 dbSNP
rs370351439 2147 dbSNP
rs1463411294 2153 dbSNP
rs553381230 2155 dbSNP
rs1351568567 2161 dbSNP
rs970259273 2166 dbSNP
rs766146063 2178 dbSNP
rs763207158 2179 dbSNP
rs747835965 2185 dbSNP
rs536991497 2186 dbSNP
rs17139041 2192 dbSNP
rs1365029862 2201 dbSNP
rs1453906958 2202 dbSNP
rs1158311888 2203 dbSNP
rs1386393986 2206 dbSNP
rs902207871 2206 dbSNP
rs1051422117 2207 dbSNP
rs997454734 2211 dbSNP
rs900393075 2212 dbSNP
rs1367098644 2219 dbSNP
rs957888223 2221 dbSNP
rs1032411879 2229 dbSNP
rs1336391302 2246 dbSNP
rs1251831497 2249 dbSNP
rs1227916303 2251 dbSNP
rs1266728172 2254 dbSNP
rs1038894463 2263 dbSNP
rs941804510 2267 dbSNP
rs978212011 2274 dbSNP
rs1214644056 2278 dbSNP
rs765366793 2278 dbSNP
rs1272932706 2279 dbSNP
rs1487748648 2280 dbSNP
rs1189073560 2282 dbSNP
rs1179519782 2286 dbSNP
rs1252293182 2286 dbSNP
rs1419105709 2287 dbSNP
rs909043876 2289 dbSNP
rs77998887 2290 dbSNP
rs1308610830 2305 dbSNP
rs140621531 2309 dbSNP
rs1211241051 2311 dbSNP
rs1165635614 2321 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions Hela
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1048187. RNA binding protein: AGO2. Condition:Hela_AGO2_CLIP_control ...

- Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al., 2013, Cell.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' gaagaccGAGGUUCAGGUCa 5'
                 :||: ||||||| 
Target 5' gggacaaUUCUCAGUCCAGg 3'
 		9 - 28
2 
miRNA  3' gaagaccgagguUCAgguca 5'
                      |||     
Target 5' ------------AGUggugg 3'
 		1 - 8
Article - Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al.
- Cell, 2013
The induction of pluripotency or trans-differentiation of one cell type to another can be accomplished with cell-lineage-specific transcription factors. Here, we report that repression of a single RNA binding polypyrimidine-tract-binding (PTB) protein, which occurs during normal brain development via the action of miR-124, is sufficient to induce trans-differentiation of fibroblasts into functional neurons. Besides its traditional role in regulated splicing, we show that PTB has a previously undocumented function in the regulation of microRNA functions, suppressing or enhancing microRNA targeting by competitive binding on target mRNA or altering local RNA secondary structure. A key event during neuronal induction is the relief of PTB-mediated blockage of microRNA action on multiple components of the REST complex, thereby derepressing a large array of neuronal genes, including miR-124 and multiple neuronal-specific transcription factors, in nonneuronal cells. This converts a negative feedback loop to a positive one to elicit cellular reprogramming to the neuronal lineage.
LinkOut: [PMID: 23313552]
CLIP-seq Support 1 for dataset GSM1048187
Method / RBP HITS-CLIP / AGO2
Cell line / Condition Hela / Hela_AGO2_CLIP_control
Location of target site ENST00000353139.5 | 3UTR | AGUGGUGGGGGACAAUUCUCAGUCCAGGA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23313552 / GSE42701
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
27 hsa-miR-378f Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT463100 ZNF609 zinc finger protein 609 2 2
MIRT469371 REST RE1 silencing transcription factor 2 6
MIRT495441 KCNJ6 potassium voltage-gated channel subfamily J member 6 2 2
MIRT513606 VPS37B VPS37B, ESCRT-I subunit 2 2
MIRT520414 TXNL1 thioredoxin like 1 2 4
MIRT525111 PRKD2 protein kinase D2 2 2
MIRT525979 SPA17 sperm autoantigenic protein 17 2 2
MIRT527002 ARL8B ADP ribosylation factor like GTPase 8B 2 2
MIRT529215 CYP20A1 cytochrome P450 family 20 subfamily A member 1 2 2
MIRT529835 ARGFX arginine-fifty homeobox 2 2
MIRT532300 HAUS3 HAUS augmin like complex subunit 3 2 2
MIRT537577 ESYT2 extended synaptotagmin 2 2 2
MIRT543140 AKT1 AKT serine/threonine kinase 1 2 2
MIRT554924 RAP1B RAP1B, member of RAS oncogene family 2 2
MIRT564970 WTAP WT1 associated protein 2 2
MIRT570115 CACNG8 calcium voltage-gated channel auxiliary subunit gamma 8 2 2
MIRT652734 TGFB2 transforming growth factor beta 2 2 2
MIRT655948 NDST1 N-deacetylase and N-sulfotransferase 1 2 2
MIRT655997 MYRF myelin regulatory factor 2 2
MIRT684875 P4HB prolyl 4-hydroxylase subunit beta 2 2
MIRT692969 LGSN lengsin, lens protein with glutamine synthetase domain 2 2
MIRT693737 ACACA acetyl-CoA carboxylase alpha 2 2
MIRT710991 PPARGC1B PPARG coactivator 1 beta 2 2
MIRT712247 RCC2 regulator of chromosome condensation 2 2 2
MIRT718602 DCTPP1 dCTP pyrophosphatase 1 2 2
MIRT723499 WDR33 WD repeat domain 33 2 2
MIRT725448 HIPK3 homeodomain interacting protein kinase 3 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-378f Gemcitabine 60750 NSC613327 approved resistant High Pancreatic Cancer cell line (PANC-1)
hsa-miR-378f Fluorouracil 3385 NSC19893 approved resistant High Pancreatic Cancer cell line (PANC-1)
hsa-miR-378f Doxorubicin 31703 NSC123127 approved sensitive High Triple-Negative Breast Cancer cell line (MDA-MB-231, MDA-MB-468)
hsa-miR-378f Oxaliplatin 6857599 NSC266046 approved sensitive High Colorectal Cancer cell line (SW480, HCT-116)
hsa-miR-378f Erlotinib 176870 NSC718781 approved resistant High Head And Neck Squamous Cell Carcinoma cell line (HN6)
hsa-mir-378f Androstenedione+Anastrozole sensitive cell line (MCF-7)
hsa-miR-378f Osimertinib 71496458 NSC779217 approved sensitive cell line (PC9)
hsa-miR-378f Doxorubicin 31703 NSC123127 approved sensitive cell line (BAS)
hsa-miR-378f Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)
hsa-miR-378f Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (1500 ng/ml)
hsa-miR-378f Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR4)
hsa-miR-378f Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR3)

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