pre-miRNA Information
pre-miRNA hsa-mir-3911   
Genomic Coordinates chr9: 127690687 - 127690795
Description Homo sapiens miR-3911 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-3911
Sequence 12| UGUGUGGAUCCUGGAGGAGGCA |33
Evidence Experimental
Experiments Illumina
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
431152 7 ClinVar
COSM3847691 15 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs943029638 2 dbSNP
rs780635543 3 dbSNP
rs371437556 6 dbSNP
rs1135401819 7 dbSNP
rs748706130 14 dbSNP
rs1403241180 15 dbSNP
rs779344153 17 dbSNP
rs755366929 21 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol RHOG   
Synonyms ARHG
Description ras homolog family member G
Transcript NM_001665   
Expression
Putative miRNA Targets on RHOG
3'UTR of RHOG
(miRNA target sites are highlighted)
>RHOG|NM_001665|3'UTR
   1 CCCTGGCACTTGGCTTGGAGGCTGCCCCTGCCCTCCCCCCACCAGTTGTGCCTTGGTGCCTTGTCCGCCTCAGCTGTGCC
  81 TTAAGGACTAATTCTGGCACCCCTTTCCAGGGGGTTCCCTGAATGCCTTTTTCTCTGAGTGCCTTTTTCTCCTTAAGGAG
 161 GCCTGCAGAGAAAGGGGCTTTGGGCTCTGCCCCCCTCTGCTTGGGAACACTGGGTATTCTCATGAGCTCATCCAAGCCAA
 241 GGTTGGACCCCTCCCCAAGAGGCCAACCCAGTGCCCCCTCCCATTTTCCGCTACTGACCAGTTCATCCAGCTTTCCACAC
 321 AGTTGTTGCTGCCTATTGTGGTGCCGCCTCAGGTTAGGGGCTCTCAGCCATCTCTAACCTCTGCCCTCGCTGCTCTTGGA
 401 ATTGCGCCCCCAAGATGCTCTCTCCCTTCTCCAATGAGGGAGCCACAGAATCCTGAGAAGGTGAATGTGCCCTAACCTGC
 481 TCCTCTGTGCCTAGGCCTTACGCATTTGCTGACTGACTCAGCCCCCATGCTTCTGGGGACCTTTCCTACCCCCATCAGCA
 561 TCAATAAAACCTCCTGTCTCCAGTGAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' acgGAGGAGGUC-CUAGGUGUGu 5'
             :|| |||||   ||||||| 
Target 5' cagTTCATCCAGCTTTCCACACa 3'
299 - 321 159.00 -21.60
2
miRNA  3' acGGAGGAGGU-----CCUAGGUGUgu 5'
            |||:|||||     ||| |||||  
Target 5' tcCCTTCTCCAATGAGGGAGCCACAga 3'
423 - 449 128.00 -24.30
3
miRNA  3' acGGAGGA-GGUCCUAGGUG-UGu 5'
            || ||| |||   |||:| || 
Target 5' tgCCCCCTCCCATTTTCCGCTACt 3'
272 - 295 112.00 -20.20
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN20825005 12 COSMIC
COSN30176348 38 COSMIC
COSN30156498 71 COSMIC
COSN30505470 90 COSMIC
COSN31482857 117 COSMIC
COSN25520378 415 COSMIC
COSN27138595 520 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1170663499 1 dbSNP
rs1398886064 3 dbSNP
rs1476341912 6 dbSNP
rs1424303928 9 dbSNP
rs1192260688 12 dbSNP
rs1476571472 13 dbSNP
rs779425938 21 dbSNP
rs1259121703 22 dbSNP
rs1210406328 25 dbSNP
rs756646376 27 dbSNP
rs1278361808 28 dbSNP
rs751022683 32 dbSNP
rs763609205 33 dbSNP
rs1259316980 35 dbSNP
rs752463502 36 dbSNP
rs1338535366 38 dbSNP
rs759428207 39 dbSNP
rs192991095 40 dbSNP
rs755710814 41 dbSNP
rs760698096 41 dbSNP
rs897394634 41 dbSNP
rs1340157108 43 dbSNP
rs748083712 44 dbSNP
rs1266013935 50 dbSNP
rs773357127 51 dbSNP
rs1236092025 56 dbSNP
rs902539446 58 dbSNP
rs111984062 62 dbSNP
rs1013558993 63 dbSNP
rs1192035907 64 dbSNP
rs895739402 66 dbSNP
rs777472747 67 dbSNP
rs933842080 69 dbSNP
rs745458014 79 dbSNP
rs1160198098 93 dbSNP
rs530419637 99 dbSNP
rs1361095587 101 dbSNP
rs922409106 107 dbSNP
rs559725496 108 dbSNP
rs955978510 113 dbSNP
rs1311361702 115 dbSNP
rs925858589 116 dbSNP
rs577525898 133 dbSNP
rs970093595 139 dbSNP
rs1022715616 140 dbSNP
rs541211871 142 dbSNP
rs774372954 149 dbSNP
rs1288524915 151 dbSNP
rs1354846396 152 dbSNP
rs778641269 155 dbSNP
rs909704881 158 dbSNP
rs1453449690 166 dbSNP
rs11558507 168 dbSNP
rs1222340086 171 dbSNP
rs1194274944 178 dbSNP
rs1452742803 178 dbSNP
rs1180294880 191 dbSNP
rs576990389 193 dbSNP
rs756935448 194 dbSNP
rs1209002094 196 dbSNP
rs1405475941 199 dbSNP
rs1442587406 203 dbSNP
rs1322232163 211 dbSNP
rs929727116 212 dbSNP
rs1280162476 213 dbSNP
rs749103114 214 dbSNP
rs976393713 223 dbSNP
rs1309527587 238 dbSNP
rs1035211376 243 dbSNP
rs558648984 249 dbSNP
rs1278184133 259 dbSNP
rs777601046 264 dbSNP
rs566693769 269 dbSNP
rs1210519767 289 dbSNP
rs897447107 290 dbSNP
rs547722642 292 dbSNP
rs1200798994 296 dbSNP
rs12289989 301 dbSNP
rs1457168605 304 dbSNP
rs149587143 318 dbSNP
rs1370123983 326 dbSNP
rs767545528 335 dbSNP
rs1000052163 336 dbSNP
rs368590748 339 dbSNP
rs1359922618 344 dbSNP
rs966792743 345 dbSNP
rs1408330526 346 dbSNP
rs1025025938 356 dbSNP
rs1399631212 358 dbSNP
rs1399033466 360 dbSNP
rs1013611367 361 dbSNP
rs1049386 363 dbSNP
rs1327196706 366 dbSNP
rs922668872 372 dbSNP
rs895120921 376 dbSNP
rs1246248572 377 dbSNP
rs1467061567 384 dbSNP
rs1056147338 388 dbSNP
rs1001442416 389 dbSNP
rs1415420086 394 dbSNP
rs1181024058 398 dbSNP
rs934486150 405 dbSNP
rs554937920 406 dbSNP
rs1179207018 415 dbSNP
rs1317451189 417 dbSNP
rs1049388 420 dbSNP
rs1258063551 434 dbSNP
rs1442782955 444 dbSNP
rs1186802922 445 dbSNP
rs969769186 450 dbSNP
rs1478529733 453 dbSNP
rs1170728662 458 dbSNP
rs1422482328 467 dbSNP
rs568321334 476 dbSNP
rs1048214588 481 dbSNP
rs1173957453 482 dbSNP
rs915591174 482 dbSNP
rs552923586 484 dbSNP
rs17173879 499 dbSNP
rs751677591 501 dbSNP
rs918336977 502 dbSNP
rs1380326948 518 dbSNP
rs959817517 522 dbSNP
rs1286236522 525 dbSNP
rs1225602614 529 dbSNP
rs1049391 533 dbSNP
rs1257947527 535 dbSNP
rs1345514903 542 dbSNP
rs1444840455 544 dbSNP
rs1376264015 548 dbSNP
rs184104321 550 dbSNP
rs1040744876 552 dbSNP
rs534885741 554 dbSNP
rs766632844 555 dbSNP
rs961807163 564 dbSNP
rs1392248435 570 dbSNP
rs910875381 571 dbSNP
rs1017206476 572 dbSNP
rs1006185856 576 dbSNP
rs1377790918 580 dbSNP
rs1466899496 582 dbSNP
rs1405798161 584 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions Hela
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1048187. RNA binding protein: AGO2. Condition:Hela_AGO2_CLIP_control ...

- Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al., 2013, Cell.

Article - Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al.
- Cell, 2013
The induction of pluripotency or trans-differentiation of one cell type to another can be accomplished with cell-lineage-specific transcription factors. Here, we report that repression of a single RNA binding polypyrimidine-tract-binding (PTB) protein, which occurs during normal brain development via the action of miR-124, is sufficient to induce trans-differentiation of fibroblasts into functional neurons. Besides its traditional role in regulated splicing, we show that PTB has a previously undocumented function in the regulation of microRNA functions, suppressing or enhancing microRNA targeting by competitive binding on target mRNA or altering local RNA secondary structure. A key event during neuronal induction is the relief of PTB-mediated blockage of microRNA action on multiple components of the REST complex, thereby derepressing a large array of neuronal genes, including miR-124 and multiple neuronal-specific transcription factors, in nonneuronal cells. This converts a negative feedback loop to a positive one to elicit cellular reprogramming to the neuronal lineage.
LinkOut: [PMID: 23313552]
CLIP-seq Support 1 for dataset GSM1048187
Method / RBP HITS-CLIP / AGO2
Cell line / Condition Hela / Hela_AGO2_CLIP_control
Location of target site ENST00000351018.4 | 3UTR | CAGUUGUUGCUGCCUA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23313552 / GSE42701
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
THCA -0.988 0.01 -0.800 0.1 4 Click to see details
BRCA 0.418 0.24 0.600 0.14 5 Click to see details
HNSC -0.219 0.32 -0.571 0.09 7 Click to see details
LUSC 0.256 0.37 -0.400 0.3 4 Click to see details
LUSC 0.256 0.37 -0.400 0.3 4 Click to see details
LUSC 0.256 0.37 -0.400 0.3 4 Click to see details
LUSC 0.256 0.37 -0.400 0.3 4 Click to see details
LUSC 0.256 0.37 -0.400 0.3 4 Click to see details
LUSC 0.256 0.37 -0.400 0.3 4 Click to see details
LUSC 0.256 0.37 -0.400 0.3 4 Click to see details
70 hsa-miR-3911 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT207399 MAT2A methionine adenosyltransferase 2A 2 6
MIRT284537 PDP2 pyruvate dehyrogenase phosphatase catalytic subunit 2 2 2
MIRT291946 TPM4 tropomyosin 4 2 2
MIRT293609 PVR poliovirus receptor 2 2
MIRT357688 PAIP2 poly(A) binding protein interacting protein 2 2 2
MIRT451607 MEIS3P1 Meis homeobox 3 pseudogene 1 2 2
MIRT452110 IFITM1 interferon induced transmembrane protein 1 2 2
MIRT457804 KLHL25 kelch like family member 25 2 2
MIRT462730 EFNB1 ephrin B1 2 2
MIRT463219 ZNF131 zinc finger protein 131 2 2
MIRT464141 VPS28 VPS28, ESCRT-I subunit 2 2
MIRT467582 SLC7A5 solute carrier family 7 member 5 2 6
MIRT470824 PLXND1 plexin D1 2 2
MIRT474230 LCLAT1 lysocardiolipin acyltransferase 1 2 2
MIRT478989 COLGALT1 collagen beta(1-O)galactosyltransferase 1 2 2
MIRT479462 CDK6 cyclin dependent kinase 6 2 2
MIRT483558 SYT2 synaptotagmin 2 2 2
MIRT484483 SLC9A1 solute carrier family 9 member A1 2 2
MIRT485224 PRICKLE1 prickle planar cell polarity protein 1 2 2
MIRT490356 DPYSL5 dihydropyrimidinase like 5 2 4
MIRT493177 MKNK2 MAP kinase interacting serine/threonine kinase 2 2 2
MIRT509802 CHAF1B chromatin assembly factor 1 subunit B 2 4
MIRT511815 HDGF heparin binding growth factor 2 2
MIRT512254 ARPP19 cAMP regulated phosphoprotein 19 2 6
MIRT513025 GPT2 glutamic--pyruvic transaminase 2 2 2
MIRT519640 ZNF772 zinc finger protein 772 2 4
MIRT531178 SIGLEC12 sialic acid binding Ig like lectin 12 (gene/pseudogene) 2 2
MIRT537870 EDA2R ectodysplasin A2 receptor 2 2
MIRT551914 IGLON5 IgLON family member 5 2 2
MIRT558359 DMTF1 cyclin D binding myb like transcription factor 1 2 2
MIRT559771 URGCP-MRPS24 URGCP-MRPS24 readthrough 2 4
MIRT559813 ZNF83 zinc finger protein 83 2 2
MIRT561999 LPP LIM domain containing preferred translocation partner in lipoma 2 2
MIRT565754 SERTAD2 SERTA domain containing 2 2 2
MIRT569423 DCAF8 DDB1 and CUL4 associated factor 8 2 2
MIRT569845 RGS5 regulator of G protein signaling 5 2 2
MIRT606928 CDK15 cyclin dependent kinase 15 2 2
MIRT607616 TMEM130 transmembrane protein 130 2 4
MIRT607629 TRIOBP TRIO and F-actin binding protein 2 2
MIRT607885 SATB1 SATB homeobox 1 2 2
MIRT607942 SSX2 SSX family member 2 2 4
MIRT608017 CARNS1 carnosine synthase 1 2 4
MIRT608036 UBLCP1 ubiquitin like domain containing CTD phosphatase 1 2 2
MIRT608063 SSX2B SSX family member 2B 2 4
MIRT608558 SBK1 SH3 domain binding kinase 1 2 6
MIRT608915 NCDN neurochondrin 2 6
MIRT615876 HIF1AN hypoxia inducible factor 1 alpha subunit inhibitor 2 4
MIRT618023 ELFN1 extracellular leucine rich repeat and fibronectin type III domain containing 1 2 2
MIRT620505 SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 2 2
MIRT628101 IL1RAPL1 interleukin 1 receptor accessory protein like 1 2 2
MIRT628700 ZNF548 zinc finger protein 548 2 2
MIRT630658 POU2F1 POU class 2 homeobox 1 2 2
MIRT643508 ZNF28 zinc finger protein 28 2 2
MIRT646379 SLC22A6 solute carrier family 22 member 6 2 2
MIRT660041 C15orf61 chromosome 15 open reading frame 61 2 2
MIRT687700 KRR1 KRR1, small subunit processome component homolog 2 2
MIRT688858 CAMKK2 calcium/calmodulin dependent protein kinase kinase 2 2 2
MIRT690443 REPIN1 replication initiator 1 2 2
MIRT690456 ZNF33A zinc finger protein 33A 2 2
MIRT693796 RHOG ras homolog family member G 2 2
MIRT694274 ZNF529 zinc finger protein 529 2 4
MIRT697697 WAC WW domain containing adaptor with coiled-coil 2 2
MIRT700242 RCC2 regulator of chromosome condensation 2 2 2
MIRT701836 MRPL37 mitochondrial ribosomal protein L37 2 2
MIRT704255 DHCR24 24-dehydrocholesterol reductase 2 2
MIRT707203 SDK2 sidekick cell adhesion molecule 2 2 2
MIRT710365 CREB5 cAMP responsive element binding protein 5 2 2
MIRT711943 WDFY1 WD repeat and FYVE domain containing 1 2 2
MIRT715496 MAZ MYC associated zinc finger protein 2 2
MIRT719250 MS4A1 membrane spanning 4-domains A1 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-3911 5-Fluorouracil approved 3385 Microarray CNE cells 22614822 2012 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-3911 Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-miR-3911 Platinum 23939 sensitive High Ovarian Cancer tissue
hsa-miR-3911 Dabrafenib 44462760 NSC764134 approved sensitive High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-3911 Vemurafenib 42611257 NSC761431 approved sensitive High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-3911 Fulvestrant 17756771 NSC719276 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-mir-3911 Vincristine 5978 approved resistant cell line (W1)
hsa-mir-3911 Androstenedione+Letrozole sensitive cell line (MCF-7)
hsa-miR-3911 Palbociclib 5330286 NSC758247 approved resistant tissue (breast cancer)
hsa-miR-3911 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-3911 Doxorubicin 31703 NSC123127 approved sensitive cell line (HS578T)
hsa-miR-3911 Tamoxifen+Fulvestrant sensitive cell line (LCC9)
hsa-miR-3911 Osimertinib 71496458 NSC779217 approved resistant cell line (H1975)
hsa-miR-3911 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-3911 Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-miR-3911 Paclitaxel/Docetaxel/Vinorelbine/Doxorubicin/Etoposide resistant cell line (Bads-200)

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