pre-miRNA Information
pre-miRNA hsa-mir-6752   
Genomic Coordinates chr11: 67490245 - 67490315
Description Homo sapiens miR-6752 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-6752-3p
Sequence 51| UCCCUGCCCCCAUACUCCCAG |71
Evidence Experimental
Experiments Meta-analysis
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs760443460 2 dbSNP
rs746450218 4 dbSNP
rs897972135 4 dbSNP
rs766020814 10 dbSNP
Putative Targets

miRNA Expression profile
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol HNRNPA1L2   
Synonyms -
Description heterogeneous nuclear ribonucleoprotein A1-like 2
Transcript NM_001011724   
Other Transcripts NM_001011725   
Expression
Putative miRNA Targets on HNRNPA1L2
3'UTR of HNRNPA1L2
(miRNA target sites are highlighted)
>HNRNPA1L2|NM_001011724|3'UTR
   1 TTAGGAAACAAAGCTTAGCAGGAGAGGAGAGCCAGAGAAGTGACAGGGAAGCTACAGGTTACAACAGATTTGTGAACTCA
  81 GCCAAGCACAGTGGTGGCAGGGCCTAGCTGCTACAAAGAAGACATGTTTTAGACAAATACTCATGTGTATGGGCAAAAAA
 161 CTCGAGGACTGTATTTGTGACTAATTGTATAACAGGTTATTTTAGTTTCTGTTCTGTGGAAAGTGTAAAGCATTCCAACA
 241 AAGTGTTTTAATGTAGATTTTTTTTTTTGCACCCATGCTGTTGATTGCTAAATGTAATAGTCTGATTGTGACGCTGAATA
 321 AATGTCTCT
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' gacCCUCAUACCCCCGUCCCu 5'
             | |  :||| ||||||| 
Target 5' caaGCACAGTGGTGGCAGGGc 3'
83 - 103 154.00 -18.50
2
miRNA  3' gaccCUCAUACCCCCGUCCCu 5'
              ||| |  | | ||||| 
Target 5' gccaGAGAA--GTGACAGGGa 3'
31 - 49 117.00 -10.70
3
miRNA  3' gacccucauaccccCGUCCcu 5'
                        |||||  
Target 5' ggaaacaaagcttaGCAGGag 3'
4 - 24 100.00 -7.40
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN19666060 23 COSMIC
COSN30535901 63 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs760477749 1 dbSNP
rs531688506 20 dbSNP
rs201514314 23 dbSNP
rs1274490414 29 dbSNP
rs1340634012 45 dbSNP
rs1488127944 46 dbSNP
rs949421147 66 dbSNP
rs1212099086 73 dbSNP
rs1298039469 75 dbSNP
rs1283655084 93 dbSNP
rs1046413699 94 dbSNP
rs1248873879 101 dbSNP
rs1316162469 119 dbSNP
rs571905739 125 dbSNP
rs1359222563 132 dbSNP
rs1226233571 139 dbSNP
rs897241109 142 dbSNP
rs1344338592 143 dbSNP
rs1324001968 146 dbSNP
rs1274699267 148 dbSNP
rs534919764 154 dbSNP
rs554539104 164 dbSNP
rs1477899450 165 dbSNP
rs574591439 172 dbSNP
rs1425153394 176 dbSNP
rs888626674 186 dbSNP
rs1477302771 192 dbSNP
rs1462595497 195 dbSNP
rs149918578 197 dbSNP
rs1201512937 206 dbSNP
rs1018946202 223 dbSNP
rs1289878809 226 dbSNP
rs145252852 238 dbSNP
rs1161639397 240 dbSNP
rs551845012 241 dbSNP
rs2575975 245 dbSNP
rs1368623925 253 dbSNP
rs559797574 254 dbSNP
rs149175417 255 dbSNP
rs1329270420 258 dbSNP
rs978520944 258 dbSNP
rs925784872 268 dbSNP
rs796921596 269 dbSNP
rs1455021674 270 dbSNP
rs1338010933 271 dbSNP
rs1382428600 274 dbSNP
rs958788142 274 dbSNP
rs1446318323 279 dbSNP
rs1193285099 280 dbSNP
rs1271519340 287 dbSNP
rs1313287631 288 dbSNP
rs1369775492 289 dbSNP
rs1252782667 291 dbSNP
rs1179760451 298 dbSNP
rs991385147 307 dbSNP
rs1236401143 308 dbSNP
rs1198147292 309 dbSNP
rs143691199 310 dbSNP
rs1281072517 311 dbSNP
rs527814646 313 dbSNP
rs1389293609 314 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions Hela
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1048187. RNA binding protein: AGO2. Condition:Hela_AGO2_CLIP_control ...

- Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al., 2013, Cell.

Article - Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al.
- Cell, 2013
The induction of pluripotency or trans-differentiation of one cell type to another can be accomplished with cell-lineage-specific transcription factors. Here, we report that repression of a single RNA binding polypyrimidine-tract-binding (PTB) protein, which occurs during normal brain development via the action of miR-124, is sufficient to induce trans-differentiation of fibroblasts into functional neurons. Besides its traditional role in regulated splicing, we show that PTB has a previously undocumented function in the regulation of microRNA functions, suppressing or enhancing microRNA targeting by competitive binding on target mRNA or altering local RNA secondary structure. A key event during neuronal induction is the relief of PTB-mediated blockage of microRNA action on multiple components of the REST complex, thereby derepressing a large array of neuronal genes, including miR-124 and multiple neuronal-specific transcription factors, in nonneuronal cells. This converts a negative feedback loop to a positive one to elicit cellular reprogramming to the neuronal lineage.
LinkOut: [PMID: 23313552]
CLIP-seq Support 1 for dataset GSM1048187
Method / RBP HITS-CLIP / AGO2
Cell line / Condition Hela / Hela_AGO2_CLIP_control
Location of target site ENST00000342657.3 | 3UTR | GGUUACAACAGAUUUGUGAACUCAGCCAAGCACAGUGGUGGCAGGGCCUAGCUGCUACAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23313552 / GSE42701
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
110 hsa-miR-6752-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT152341 TNFSF9 TNF superfamily member 9 2 2
MIRT273594 SP1 Sp1 transcription factor 2 2
MIRT291927 TPM4 tropomyosin 4 2 4
MIRT311186 ANKRD33B ankyrin repeat domain 33B 2 4
MIRT378521 CDKN1A cyclin dependent kinase inhibitor 1A 2 4
MIRT452467 SORCS2 sortilin related VPS10 domain containing receptor 2 2 2
MIRT478636 CTDNEP1 CTD nuclear envelope phosphatase 1 2 2
MIRT496343 TMEM81 transmembrane protein 81 2 2
MIRT496646 MFAP3 microfibril associated protein 3 2 2
MIRT496711 DNAJC30 DnaJ heat shock protein family (Hsp40) member C30 2 2
MIRT499242 VAV3 vav guanine nucleotide exchange factor 3 2 4
MIRT519777 ZNF354B zinc finger protein 354B 2 6
MIRT520883 STX17 syntaxin 17 2 2
MIRT522476 ZAK mitogen-activated protein kinase kinase kinase 20 2 2
MIRT523587 G3BP2 G3BP stress granule assembly factor 2 2 6
MIRT525240 KCNJ12 potassium voltage-gated channel subfamily J member 12 2 2
MIRT527025 PABPN1L poly(A) binding protein nuclear 1 like, cytoplasmic 2 2
MIRT527709 IL17REL interleukin 17 receptor E like 2 2
MIRT530778 GPD1 glycerol-3-phosphate dehydrogenase 1 2 2
MIRT531883 SCN1B sodium voltage-gated channel beta subunit 1 2 2
MIRT533043 ZBTB46 zinc finger and BTB domain containing 46 2 2
MIRT535062 PPP2R5D protein phosphatase 2 regulatory subunit B'delta 2 4
MIRT536512 KCTD15 potassium channel tetramerization domain containing 15 2 2
MIRT543793 RALGAPB Ral GTPase activating protein non-catalytic beta subunit 2 2
MIRT563977 HCFC1 host cell factor C1 2 2
MIRT569472 MAN2A2 mannosidase alpha class 2A member 2 2 2
MIRT570600 NFIX nuclear factor I X 2 2
MIRT571402 MED4 mediator complex subunit 4 2 2
MIRT608418 PPIC peptidylprolyl isomerase C 2 6
MIRT608928 REXO2 RNA exonuclease 2 2 4
MIRT609357 ZNF664 zinc finger protein 664 2 2
MIRT611189 WBSCR17 polypeptide N-acetylgalactosaminyltransferase 17 2 4
MIRT615266 DPF2 double PHD fingers 2 2 2
MIRT615408 VDAC2 voltage dependent anion channel 2 2 2
MIRT616323 AGO3 argonaute 3, RISC catalytic component 2 2
MIRT616566 ZNF512B zinc finger protein 512B 2 2
MIRT616745 TAZ tafazzin 2 2
MIRT617316 MBOAT1 membrane bound O-acyltransferase domain containing 1 2 2
MIRT620030 NFAM1 NFAT activating protein with ITAM motif 1 2 2
MIRT621166 RTTN rotatin 2 2
MIRT623501 KCNQ3 potassium voltage-gated channel subfamily Q member 3 2 2
MIRT623524 KCNK10 potassium two pore domain channel subfamily K member 10 2 2
MIRT629683 TNFAIP8L1 TNF alpha induced protein 8 like 1 2 2
MIRT630795 TGIF2 TGFB induced factor homeobox 2 2 2
MIRT634638 HIP1 huntingtin interacting protein 1 2 4
MIRT636788 RAB40B RAB40B, member RAS oncogene family 2 2
MIRT640332 DAAM2 dishevelled associated activator of morphogenesis 2 2 2
MIRT640557 SMCR8 Smith-Magenis syndrome chromosome region, candidate 8 2 2
MIRT643319 TMEM151B transmembrane protein 151B 2 2
MIRT643991 DUSP28 dual specificity phosphatase 28 2 2
MIRT644618 CD300E CD300e molecule 2 2
MIRT646445 XRCC2 X-ray repair cross complementing 2 2 2
MIRT648020 SLCO4C1 solute carrier organic anion transporter family member 4C1 2 2
MIRT648077 ZMIZ2 zinc finger MIZ-type containing 2 2 2
MIRT649618 ITPKC inositol-trisphosphate 3-kinase C 2 2
MIRT650414 ZNF442 zinc finger protein 442 2 2
MIRT650850 SEMA4G semaphorin 4G 2 2
MIRT654694 PSMB5 proteasome subunit beta 5 2 2
MIRT655512 PAIP2B poly(A) binding protein interacting protein 2B 2 2
MIRT657620 GRAP2 GRB2-related adaptor protein 2 2 2
MIRT658009 GALNT10 polypeptide N-acetylgalactosaminyltransferase 10 2 2
MIRT658329 FAM83F family with sequence similarity 83 member F 2 2
MIRT658832 SRCAP Snf2 related CREBBP activator protein 2 2
MIRT658920 DPY19L4 dpy-19 like 4 2 2
MIRT661058 RPL18A ribosomal protein L18a 2 2
MIRT662342 MYLK3 myosin light chain kinase 3 2 2
MIRT663451 FBXO2 F-box protein 2 2 2
MIRT676752 SGTB small glutamine rich tetratricopeptide repeat containing beta 2 4
MIRT684705 LRRD1 leucine rich repeats and death domain containing 1 2 2
MIRT687247 PDHB pyruvate dehydrogenase E1 beta subunit 2 2
MIRT693881 NT5C2 5'-nucleotidase, cytosolic II 2 2
MIRT693922 HNRNPA1L2 heterogeneous nuclear ribonucleoprotein A1-like 2 2 2
MIRT695921 ZNF174 zinc finger protein 174 2 2
MIRT702867 HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 2 2
MIRT708863 TMSB4X thymosin beta 4, X-linked 2 2
MIRT708936 CRY2 cryptochrome circadian clock 2 2 2
MIRT709476 FAXC failed axon connections homolog 2 2
MIRT709752 UBD ubiquitin D 2 2
MIRT710128 VANGL2 VANGL planar cell polarity protein 2 2 2
MIRT710274 FAM107A family with sequence similarity 107 member A 2 2
MIRT711146 TMEM174 transmembrane protein 174 2 2
MIRT712582 ATP2B4 ATPase plasma membrane Ca2+ transporting 4 2 2
MIRT712648 TXNL4A thioredoxin like 4A 2 2
MIRT713325 TMEM44 transmembrane protein 44 2 2
MIRT713413 PEX16 peroxisomal biogenesis factor 16 2 2
MIRT713891 RNF19B ring finger protein 19B 2 2
MIRT714549 COL14A1 collagen type XIV alpha 1 chain 2 2
MIRT714809 ARHGEF19 Rho guanine nucleotide exchange factor 19 2 2
MIRT714840 SCAMP2 secretory carrier membrane protein 2 2 2
MIRT715779 DDX42 DEAD-box helicase 42 2 2
MIRT715795 TBL3 transducin beta like 3 2 2
MIRT716088 RNF150 ring finger protein 150 2 2
MIRT716712 IMP4 IMP4, U3 small nucleolar ribonucleoprotein 2 2
MIRT716737 APOL6 apolipoprotein L6 2 2
MIRT717069 MTMR6 myotubularin related protein 6 2 2
MIRT718185 HLCS holocarboxylase synthetase 2 2
MIRT719386 SECTM1 secreted and transmembrane 1 2 2
MIRT720679 SLC39A13 solute carrier family 39 member 13 2 2
MIRT721315 FAM58A cyclin Q 2 2
MIRT721396 LDLRAD4 low density lipoprotein receptor class A domain containing 4 2 2
MIRT721896 ITPR2 inositol 1,4,5-trisphosphate receptor type 2 2 2
MIRT722442 ZBTB7B zinc finger and BTB domain containing 7B 2 2
MIRT723009 FADS1 fatty acid desaturase 1 2 2
MIRT723675 CTC1 CST telomere replication complex component 1 2 2
MIRT723774 ROBO4 roundabout guidance receptor 4 2 2
MIRT723814 OR1L8 olfactory receptor family 1 subfamily L member 8 2 2
MIRT723959 TMEM184A transmembrane protein 184A 2 2
MIRT724449 OPA3 OPA3, outer mitochondrial membrane lipid metabolism regulator 2 2
MIRT724798 C1D C1D nuclear receptor corepressor 2 2
MIRT725626 CAMKV CaM kinase like vesicle associated 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-6752-3p Cisplatin 5460033 NSC119875 approved resistant cell line (A549)
hsa-miR-6752-3p Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)

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