miRTarBase - #MIRT694006


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pre-miRNA Information
pre-miRNA hsa-mir-3160-1   
Genomic Coordinates chr11: 46451805 - 46451889
Description Homo sapiens miR-3160-1 stem-loop
Comment None
RNA Secondary Structure
pre-miRNA hsa-mir-3160-2   
Genomic Coordinates chr11: 46451807 - 46451887
Description Homo sapiens miR-3160-2 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-3160-3p
Sequence 54| AGAGCUGAGACUAGAAAGCCCA |75
Evidence Experimental
Experiments Illumina
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN30582333 1 COSMIC
COSN1535547 3 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1396368683 1 dbSNP
rs1162409303 2 dbSNP
rs1404378453 12 dbSNP
rs1171960732 14 dbSNP
rs1324633375 16 dbSNP
rs1187765019 16 dbSNP
rs1300058326 19 dbSNP
rs1432898407 21 dbSNP
rs1011279103 22 dbSNP
Putative Targets

miRNA Expression profile
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol PPIL4   
Synonyms HDCME13P
Description peptidylprolyl isomerase like 4
Transcript NM_139126   
Expression
Putative miRNA Targets on PPIL4
3'UTR of PPIL4
(miRNA target sites are highlighted)		 
>PPIL4|NM_139126|3'UTR
   1 AAGATGAAGAGGCAGAATTGAGAGGCTAACATATTTACTCTTGTCTAACTTAAGAGTGCCAGGAAAGCAGATGCTTAGAT
  81 TTTGTGTCAAAGCTTGTTATTTTTTTCATACTAGGATTATGGTCTTTAGATTAATACTGATTATATAGAGCACGGAAAGA
 161 TAAAGAATTGAACATTTTCTTTGTATACTTTTTTACACTAATTTTATTGTTATACATAAATGGTAGTCTTCATTTTTGAA
 241 GTCTTACATTTTCACTCTTTTTTTAATGAAGTATTTCATACTACAAAAATACATAAACGTATATATAAAGGGATAATAAA
 321 TGTAAATATCTGTGTACTCATCAGCCAGCTTAAGATACAGATGTTGTCGACATTTTAGAAGTTCCCTAAGGCCCTCTCCC
 401 TCTCAAATAATTATTTGGAATTTTGTGTTTGTCATTTGTCTATTATAGTTTTACAACATACGTATGTATCTGTAAGTGAA
 481 ATGTTAATTTTGTATGTTTCTGAATTTTATATAAATGGCAAAATGTTTACTTCTGTGACTTTCTTTCATTTTTATTGCTA
 561 TATAGTATTATATAAATATACTACAACTTATTCATTCTTGATGGACATTTGAGTTTTGTTTATTTGTTTTTGCTGTTGAA
 641 ACAATGCTGCTGTGAACATTGTATCTAGCAGTTATATTGCTTGATATATTGATAAAATAATGCCAAATTTGTGTTCTGAA
 721 GTGACTGTACTAGTTTATACCTCTCTTGGCACTGTGAGTTACCTTTGTTTCATAGCATCTCCAACACTTAAGTTCAGACT
 801 TAAAAATTTGCCAACCTAGTGGATGTTAAGTGGTATCTACCTGTGATTTCCAGCAAGATTACTGTTATCTCTGCTCTTCC
 881 ATGTGTAAGATGTCATTTTTTTCCTGGCTGCTTTTAAGGTTTTCTGTCACTGGTTGTAAGAAGTTTGATTATGATGTGAA
 961 AAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' accCGAAAGAU--CAGAGUCGAGa 5'
             | || ||:   |||| |||| 
Target 5' caaGATTACTGTTATCTCTGCTCt 3'
 854 - 877 125.00 -12.50
2 
miRNA  3' acccGAAAGAUCAG-AGUCGaga 5'
              || | || || |||||   
Target 5' atatCTGTGTACTCATCAGCcag 3'
 326 - 348 118.00 -6.82
3 
miRNA  3' accCGAA---AGAUCAGAG--UCGAGa 5'
             ||||   |:| || ||  ||||: 
Target 5' gatGCTTAGATTTTGTGTCAAAGCTTg 3'
 70 - 96 107.00 -8.00
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30111388 18 COSMIC
COSN30123828 27 COSMIC
COSN30165811 31 COSMIC
COSN30529174 101 COSMIC
COSN31510595 128 COSMIC
COSN30177399 146 COSMIC
COSN31543655 150 COSMIC
COSN30536628 164 COSMIC
COSN31585455 204 COSMIC
COSN16958302 462 COSMIC
COSN20966474 593 COSMIC
COSN7694032 613 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs374807873 3 dbSNP
rs776224862 4 dbSNP
rs770368270 18 dbSNP
rs760173897 24 dbSNP
rs774724138 26 dbSNP
rs199529936 29 dbSNP
rs1474724429 30 dbSNP
rs1188278282 31 dbSNP
rs1355756168 35 dbSNP
rs749724789 38 dbSNP
rs1451549197 44 dbSNP
rs750765344 54 dbSNP
rs772233371 70 dbSNP
rs545991228 84 dbSNP
rs1405971415 90 dbSNP
rs575461000 97 dbSNP
rs1237108405 107 dbSNP
rs561855961 108 dbSNP
rs1013931820 110 dbSNP
rs1041681459 115 dbSNP
rs542021908 129 dbSNP
rs1243312517 137 dbSNP
rs1313833967 143 dbSNP
rs189949323 148 dbSNP
rs1211056449 153 dbSNP
rs74367049 154 dbSNP
rs1445741402 158 dbSNP
rs1015173672 164 dbSNP
rs1249036376 165 dbSNP
rs1182149913 173 dbSNP
rs1451651787 173 dbSNP
rs1004554627 174 dbSNP
rs1473268053 175 dbSNP
rs1165045757 179 dbSNP
rs931960077 185 dbSNP
rs1439730411 188 dbSNP
rs1456627640 204 dbSNP
rs779340888 213 dbSNP
rs976184920 216 dbSNP
rs1450114002 226 dbSNP
rs1290265001 248 dbSNP
rs887560777 248 dbSNP
rs1027275923 253 dbSNP
rs966640268 257 dbSNP
rs1451070562 259 dbSNP
rs1344069708 260 dbSNP
rs908031832 260 dbSNP
rs1269260067 261 dbSNP
rs1466658839 264 dbSNP
rs566294499 265 dbSNP
rs900071496 266 dbSNP
rs1443193510 274 dbSNP
rs983558874 281 dbSNP
rs1039927309 289 dbSNP
rs952306966 298 dbSNP
rs553095625 299 dbSNP
rs1414030112 300 dbSNP
rs974185058 303 dbSNP
rs1468193912 310 dbSNP
rs1449837599 311 dbSNP
rs1171745771 321 dbSNP
rs1264194650 331 dbSNP
rs768984800 334 dbSNP
rs958391704 340 dbSNP
rs149457606 343 dbSNP
rs1397400730 348 dbSNP
rs1326373919 356 dbSNP
rs1349514748 362 dbSNP
rs115247701 368 dbSNP
rs1002610607 369 dbSNP
rs906930773 377 dbSNP
rs1020144820 384 dbSNP
rs1052614279 386 dbSNP
rs1231769608 408 dbSNP
rs1255757066 410 dbSNP
rs1256627795 426 dbSNP
rs1202547776 427 dbSNP
rs7773304 439 dbSNP
rs925381570 440 dbSNP
rs1182937509 458 dbSNP
rs781007895 458 dbSNP
rs979413024 459 dbSNP
rs1198143764 461 dbSNP
rs1054369616 462 dbSNP
rs1467340006 466 dbSNP
rs1165965839 467 dbSNP
rs536666336 469 dbSNP
rs916587295 471 dbSNP
rs1309293333 474 dbSNP
rs932009535 478 dbSNP
rs137953320 479 dbSNP
rs1040881781 481 dbSNP
rs1332192580 494 dbSNP
rs944827092 502 dbSNP
rs1328553975 509 dbSNP
rs907931927 511 dbSNP
rs991361408 517 dbSNP
rs554875035 519 dbSNP
rs1341681043 529 dbSNP
rs1297336408 535 dbSNP
rs1276843562 537 dbSNP
rs1380139280 542 dbSNP
rs1487582310 545 dbSNP
rs1209337236 547 dbSNP
rs548077454 548 dbSNP
rs879517603 549 dbSNP
rs1312890330 552 dbSNP
rs1014701584 565 dbSNP
rs983586749 566 dbSNP
rs1449686445 569 dbSNP
rs1170164340 572 dbSNP
rs1363336030 575 dbSNP
rs1456916573 578 dbSNP
rs1373626539 579 dbSNP
rs951781704 581 dbSNP
rs930810217 588 dbSNP
rs995895766 591 dbSNP
rs1364994320 598 dbSNP
rs1374549700 606 dbSNP
rs1191348398 607 dbSNP
rs115878264 612 dbSNP
rs62442791 613 dbSNP
rs1019031323 616 dbSNP
rs1258335809 622 dbSNP
rs577125373 622 dbSNP
rs1206811440 624 dbSNP
rs1008447941 626 dbSNP
rs991075956 626 dbSNP
rs1190079161 643 dbSNP
rs1190288348 644 dbSNP
rs1382952679 645 dbSNP
rs958640935 649 dbSNP
rs1164826033 656 dbSNP
rs1369743253 663 dbSNP
rs935512783 675 dbSNP
rs1319209746 679 dbSNP
rs1388549212 689 dbSNP
rs1436216912 691 dbSNP
rs746915085 699 dbSNP
rs904033557 704 dbSNP
rs1228015292 707 dbSNP
rs1034038495 726 dbSNP
rs565977432 729 dbSNP
rs1043807554 740 dbSNP
rs948138147 743 dbSNP
rs186721596 744 dbSNP
rs1329799334 748 dbSNP
rs1224804769 757 dbSNP
rs1306489768 762 dbSNP
rs992600591 764 dbSNP
rs557224671 765 dbSNP
rs939280230 773 dbSNP
rs1182141631 777 dbSNP
rs1257652878 780 dbSNP
rs1471284210 784 dbSNP
rs1157785112 792 dbSNP
rs1020004405 793 dbSNP
rs907821803 811 dbSNP
rs1161801868 825 dbSNP
rs1458268578 825 dbSNP
rs1416148902 826 dbSNP
rs1010110634 831 dbSNP
rs1447568052 833 dbSNP
rs1303577762 849 dbSNP
rs1381637277 853 dbSNP
rs1408022365 861 dbSNP
rs1287841861 862 dbSNP
rs1350997811 868 dbSNP
rs1230203867 880 dbSNP
rs1276224496 888 dbSNP
rs983236727 892 dbSNP
rs951853453 897 dbSNP
rs892965052 901 dbSNP
rs1257331083 903 dbSNP
rs1312237591 905 dbSNP
rs1027463434 908 dbSNP
rs1251974955 912 dbSNP
rs1473199066 930 dbSNP
rs974482030 940 dbSNP
rs1033371563 942 dbSNP
rs1423692465 946 dbSNP
rs996089644 955 dbSNP
rs900392792 956 dbSNP
rs1040387044 958 dbSNP
rs1177277461 959 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions Hela
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1048187. RNA binding protein: AGO2. Condition:Hela_AGO2_CLIP_control ...

- Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al., 2013, Cell.

Article - Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al.
- Cell, 2013
The induction of pluripotency or trans-differentiation of one cell type to another can be accomplished with cell-lineage-specific transcription factors. Here, we report that repression of a single RNA binding polypyrimidine-tract-binding (PTB) protein, which occurs during normal brain development via the action of miR-124, is sufficient to induce trans-differentiation of fibroblasts into functional neurons. Besides its traditional role in regulated splicing, we show that PTB has a previously undocumented function in the regulation of microRNA functions, suppressing or enhancing microRNA targeting by competitive binding on target mRNA or altering local RNA secondary structure. A key event during neuronal induction is the relief of PTB-mediated blockage of microRNA action on multiple components of the REST complex, thereby derepressing a large array of neuronal genes, including miR-124 and multiple neuronal-specific transcription factors, in nonneuronal cells. This converts a negative feedback loop to a positive one to elicit cellular reprogramming to the neuronal lineage.
LinkOut: [PMID: 23313552]
CLIP-seq Support 1 for dataset GSM1048187
Method / RBP HITS-CLIP / AGO2
Cell line / Condition Hela / Hela_AGO2_CLIP_control
Location of target site ENST00000340881.2 | 3UTR | UGCCCAGGCUGGAGUGCAGUGGCGCCAUCUCAGCUCACUGCAGCCUCUGCCUCC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23313552 / GSE42701
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
Click to see details
118 hsa-miR-3160-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT066658 DYRK2 dual specificity tyrosine phosphorylation regulated kinase 2 2 2
MIRT075318 SF3B3 splicing factor 3b subunit 3 2 4
MIRT077083 EIF1 eukaryotic translation initiation factor 1 2 2
MIRT100381 HSPA1B heat shock protein family A (Hsp70) member 1B 2 6
MIRT135259 TMBIM6 transmembrane BAX inhibitor motif containing 6 2 4
MIRT184913 ZNF268 zinc finger protein 268 2 2
MIRT218862 CDKN1A cyclin dependent kinase inhibitor 1A 2 2
MIRT446580 FPR2 formyl peptide receptor 2 2 2
MIRT448834 FGD4 FYVE, RhoGEF and PH domain containing 4 2 2
MIRT449455 RNF13 ring finger protein 13 2 2
MIRT452284 CARD8 caspase recruitment domain family member 8 2 2
MIRT452628 FAM162A family with sequence similarity 162 member A 2 2
MIRT453454 GLG1 golgi glycoprotein 1 2 2
MIRT454188 AP1S3 adaptor related protein complex 1 sigma 3 subunit 2 6
MIRT454434 GTF2F1 general transcription factor IIF subunit 1 2 2
MIRT454575 NT5DC3 5'-nucleotidase domain containing 3 2 2
MIRT455555 TRAF1 TNF receptor associated factor 1 2 6
MIRT455841 MPL MPL proto-oncogene, thrombopoietin receptor 2 6
MIRT455969 BCAS4 breast carcinoma amplified sequence 4 2 4
MIRT456805 SIGLEC14 sialic acid binding Ig like lectin 14 2 2
MIRT457320 DUSP19 dual specificity phosphatase 19 2 2
MIRT457366 POFUT2 protein O-fucosyltransferase 2 2 2
MIRT457684 ZNF587 zinc finger protein 587 2 2
MIRT458158 LYRM4 LYR motif containing 4 2 6
MIRT458641 SGPP2 sphingosine-1-phosphate phosphatase 2 2 2
MIRT459134 FADS6 fatty acid desaturase 6 2 2
MIRT459153 NARF nuclear prelamin A recognition factor 2 4
MIRT460460 NOM1 nucleolar protein with MIF4G domain 1 2 4
MIRT460974 STK17B serine/threonine kinase 17b 2 2
MIRT461439 ACSBG1 acyl-CoA synthetase bubblegum family member 1 2 2
MIRT461507 NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 2 2
MIRT462490 GSR glutathione-disulfide reductase 2 2
MIRT462638 PHF5A PHD finger protein 5A 2 2
MIRT463279 ZFX zinc finger protein, X-linked 2 2
MIRT463360 ZFAND4 zinc finger AN1-type containing 4 2 2
MIRT465777 TMOD3 tropomodulin 3 2 2
MIRT466143 TMEM120B transmembrane protein 120B 2 2
MIRT468401 SETD3 SET domain containing 3 2 2
MIRT468998 RNPS1 RNA binding protein with serine rich domain 1 2 2
MIRT471574 PARD6B par-6 family cell polarity regulator beta 2 2
MIRT472108 NME2 NME/NM23 nucleoside diphosphate kinase 2 2 2
MIRT472125 NME1-NME2 NME1-NME2 readthrough 2 2
MIRT473020 MRPS14 mitochondrial ribosomal protein S14 2 2
MIRT473083 MORN4 MORN repeat containing 4 2 2
MIRT475598 HMGB2 high mobility group box 2 2 4
MIRT475937 GXYLT2 glucoside xylosyltransferase 2 2 8
MIRT476117 GPR157 G protein-coupled receptor 157 2 2
MIRT476406 GDE1 glycerophosphodiester phosphodiesterase 1 2 2
MIRT478003 DNAL1 dynein axonemal light chain 1 2 2
MIRT487969 IQSEC2 IQ motif and Sec7 domain 2 2 2
MIRT489418 TUBB2A tubulin beta 2A class IIa 2 2
MIRT491522 IL10RA interleukin 10 receptor subunit alpha 2 2
MIRT492673 PLEC plectin 2 2
MIRT493545 ICOSLG inducible T-cell costimulator ligand 2 2
MIRT513085 USP9X ubiquitin specific peptidase 9, X-linked 2 2
MIRT514009 CECR2 CECR2, histone acetyl-lysine reader 2 4
MIRT516683 ZNF860 zinc finger protein 860 2 2
MIRT518392 ZNF250 zinc finger protein 250 2 2
MIRT522683 LUZP1 leucine zipper protein 1 2 6
MIRT524488 CEP97 centrosomal protein 97 2 2
MIRT527457 CLEC12B C-type lectin domain family 12 member B 2 2
MIRT527705 IL17REL interleukin 17 receptor E like 2 2
MIRT531647 C19orf52 translocase of inner mitochondrial membrane 29 2 2
MIRT532381 UMPS uridine monophosphate synthetase 2 2
MIRT532588 MTHFD1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 2 2
MIRT533555 TPM4 tropomyosin 4 2 2
MIRT548371 ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5 2 4
MIRT550250 PVR poliovirus receptor 2 2
MIRT552555 ZFP36L2 ZFP36 ring finger protein like 2 2 4
MIRT554113 SMARCE1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 2 2
MIRT554131 SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 2 2
MIRT561344 ZBTB18 zinc finger and BTB domain containing 18 2 2
MIRT561638 RUNX3 runt related transcription factor 3 2 2
MIRT566497 PBX2P1 PBX homeobox 2 pseudogene 1 2 2
MIRT570583 OTUD7B OTU deubiquitinase 7B 2 2
MIRT572731 MCTS1 MCTS1, re-initiation and release factor 2 2
MIRT574041 PEX26 peroxisomal biogenesis factor 26 2 2
MIRT575231 Fut1 fucosyltransferase 1 2 2
MIRT606811 BICD2 BICD cargo adaptor 2 2 2
MIRT621016 CLSTN3 calsyntenin 3 2 2
MIRT637852 PDCL3 phosducin like 3 2 2
MIRT640477 ZNF557 zinc finger protein 557 2 2
MIRT642827 LINC00346 long intergenic non-protein coding RNA 346 2 2
MIRT643887 IMP4 IMP4, U3 small nucleolar ribonucleoprotein 2 2
MIRT664874 PCNXL2 pecanex homolog 2 2 2
MIRT680528 PRIM2 DNA primase subunit 2 2 2
MIRT680648 KIAA1456 KIAA1456 2 2
MIRT680807 ZNF578 zinc finger protein 578 2 2
MIRT680921 STX2 syntaxin 2 2 2
MIRT681112 CEP57L1 centrosomal protein 57 like 1 2 2
MIRT681147 INTS7 integrator complex subunit 7 2 2
MIRT681966 TFCP2 transcription factor CP2 2 2
MIRT684316 GTF3C4 general transcription factor IIIC subunit 4 2 2
MIRT684906 GSG2 histone H3 associated protein kinase 2 2
MIRT685499 MED16 mediator complex subunit 16 2 2
MIRT685929 MOCS3 molybdenum cofactor synthesis 3 2 2
MIRT686875 SLC25A32 solute carrier family 25 member 32 2 2
MIRT688204 FNIP1 folliculin interacting protein 1 2 2
MIRT688791 CCNB1 cyclin B1 2 2
MIRT689227 RPS19 ribosomal protein S19 2 2
MIRT690470 ZNF33A zinc finger protein 33A 2 2
MIRT691982 PLCXD1 phosphatidylinositol specific phospholipase C X domain containing 1 2 2
MIRT694006 PPIL4 peptidylprolyl isomerase like 4 2 2
MIRT694529 TRIM72 tripartite motif containing 72 2 2
MIRT695420 ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide 2 2
MIRT695784 HSD17B12 hydroxysteroid 17-beta dehydrogenase 12 2 2
MIRT697799 UBXN2A UBX domain protein 2A 2 2
MIRT698275 TMEM2 transmembrane protein 2 2 2
MIRT698317 TMEM136 transmembrane protein 136 2 2
MIRT699971 RREB1 ras responsive element binding protein 1 2 2
MIRT700717 PNO1 partner of NOB1 homolog 2 2
MIRT701721 MTMR12 myotubularin related protein 12 2 2
MIRT701879 MPLKIP M-phase specific PLK1 interacting protein 2 2
MIRT702959 HIF1A hypoxia inducible factor 1 alpha subunit 2 2
MIRT706178 ZNF716 zinc finger protein 716 2 2
MIRT706463 SPRED1 sprouty related EVH1 domain containing 1 2 2
MIRT718154 TTC33 tetratricopeptide repeat domain 33 2 2
MIRT718711 ANKRD18A ankyrin repeat domain 18A 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-3160-3p Gefitinib 123631 NSC715055 approved resistant cell line (PC9)
hsa-miR-3160-3p Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-3160-3p Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-miR-3160-3p Tripterygium wilfordii Hook F resistant tissue
hsa-miR-3160-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-3160-3p Paclitaxel/Docetaxel/Vinorelbine/Doxorubicin/Etoposide resistant cell line (Bads-200)

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