pre-miRNA Information | |
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pre-miRNA | hsa-mir-3911 |
Genomic Coordinates | chr9: 127690687 - 127690795 |
Description | Homo sapiens miR-3911 stem-loop |
Comment | None |
RNA Secondary Structure | ![]() |
Mature miRNA Information | ||||||||||||||||||||||||||||
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Mature miRNA | hsa-miR-3911 | |||||||||||||||||||||||||||
Sequence | 12| UGUGUGGAUCCUGGAGGAGGCA |33 | |||||||||||||||||||||||||||
Evidence | Experimental | |||||||||||||||||||||||||||
Experiments | Illumina | DRVs in miRNA |
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SNPs in miRNA |
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Putative Targets |
miRNA Expression profile | |
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Human miRNA Tissue Atlas | |
miRNAs in Extracellular Vesicles |
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Circulating MicroRNA Expression Profiling |
Gene Information | |||||||||||||||||||||
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Gene Symbol | ZNF529 | ||||||||||||||||||||
Synonyms | - | ||||||||||||||||||||
Description | zinc finger protein 529 | ||||||||||||||||||||
Transcript | NM_001145649 | ||||||||||||||||||||
Other Transcripts | NM_001145650 , NM_020951 | ||||||||||||||||||||
Expression | |||||||||||||||||||||
Putative miRNA Targets on ZNF529 | |||||||||||||||||||||
3'UTR of ZNF529 (miRNA target sites are highlighted) |
>ZNF529|NM_001145649|3'UTR 1 AATAAATGTATAAAGTGGTTTTTTATTTCTGATTTTCACAGGAAAATACTGTGGATGGATTTAATAGGTAATCAAGGCAA 81 TTCAGTATCTCCCTCTCTTAAAGTCTGTTTTTAGACTTCATGGTCATTCTGTATGTAGACGTAGAATTGCTTAGTCATAG 161 CTGATATATACTTATAGCTTTGTTAGATGTTGCCAAATATTTCTCCTTTTTATGTTAAAAAGTTTTTTTCATGAGTTTCT 241 CATCCTGGCATGTTTTGTTTACAATAGCTTTTGATGTTTGTATTATTGCTCTTTTGACTATTCAGTTTTTTAATTGTAAT 321 ATTACTTCAATATCTTTTCTGCATTGTAATTCTTTGCTTGTGATATCTATACTTACTTATTTTCCTCCACAGAGTTAGCA 401 CTCCTAGTCAGATACAATGTATTTTTACAGTCTTACAGCTCATCATTTTGTGTAATGTTGTTTTGTTTTGTTTTAAATGA 481 TAGAAGTGTGATCTCCTTTCCATTTTCATCCAATTGTTGACTTCTCTTTAAATTTCTACTTTATTTTGATACAACATATT 561 CCCCCCAAAAAAACACATACATAGGAACTGGTTATATTCCACCATAACACACACACACACACACACACACTATATACATA 641 TAGTGTATATACACATATAGTGTATATAGTGTATGTGTGATGTATACTATACATATCACATATACTATATGTGTGTATAT 721 AGTGTGTGATGTATATGTGTGTGATGTATACTATATATGCCCACACATGCACTACATAACACACTATATATATATATATA 801 TATACACACACACACACACAATATATGTATATATAGTATATACACTATATACTGGGCACTATATATATATAGTGTGTATG 881 TGTGTTATATTGGAATATAACCAGTTCCTTTAAGCAGTCTTTTTACCTGCAGGCTATACCAACCAGGATCCAAATGAAGA 961 GAACTCTTTTAAATATTTGATAAAACTACTCACCCAGTAAGTCTCTTAAAATTTATCATTCTCTTAAAGTATCACTCTAA 1041 AATTTGTCAAACACCTTTAAAAGGGGAGAAAAAATGACCACTGAACTTACATTAAGAGAATTTACAACTATATATTAACA 1121 TGGCTTCAATTGTTTTTTTAATCTATTATCATTATTTTTCTTTTTATTCCCTCTCAGAGTTGACTTACTAGGTTTGGGCA 1201 TTTCAACAATCAGCAGACCTTCTTTGGTTTAACTAATCTCATTTAACTCCAAAATCATCTCTCTCTTAGGACTGCTGACT 1281 TGGTTATGCAGTCAATGAGATCACGAGCCACTGGTTATTGGATTTTTTTTCTTTTTTTTTAGACAGAGTTTTGCTCTTGT 1361 TGCCTAGGCTGGAGTGCAGTGGCGCAGTCTTGGCTCACCTCAACCTCTGCCTCCCAGGTTCAGGCTATTCTCCTGCTCAG 1441 CCTCCTGATTAGCTGGGATTACAGGCATGCGCCACCATGACCGGCTAATTTTATATTTTTAGTAGAGACGGGATATCTCC 1521 GTGTTGGTCAGTCTGGTCTCAAACTCCCGACCTCAGGTGATCCACCCGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGC 1601 ATGAGCCACCGCACCCAGCCTGGTTATTGGATTTATTTATTTATTTTGAGATAGAGCCTTGCTCTGTCACCAGGCCGGAG 1681 TGCAGTGGTGTCATCTCAGATCACTGCAACCTCCACCTCCCAGGTTCAAGCGATTCCCCTGCCTCAGCCTGCCAAGTAGC 1761 TGGGATTACAGGCATGCGCCACCATGCCCAGCTAATTGTATTTTAGTAGATATGGAGTTTCACCACGTTGGCCAAGACAG 1841 TCTCGATTTCCTGACCTTGTGATCCCCCTGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCACGCCTGT 1921 CCGGTTATTTGATTTTTATAAGAAAATTTTACTATTATTTTCAGATAAATTTATGTCACTGTCATTCATTACATTTTAAT 2001 TTTTGAAACTGATGTCTTTCCCAGAATTTATGTACTCTATAACGGTGTGAATGATTACCAGTATTAAGCCATTTTCTCAT 2081 CTGATATATTGAGCTATGTTTTATGTAAGTATTGCTTATTCAAGTAGTTTTAAAAGATATGTAATTGGTTGTTGTTTCAT 2161 GTCCTACACAGTAAGAACAAGAGTATGTTAACCTTTTTGTCAGGATATTTGCTATTTCATATCTTTGAAATAGAGTAGTA 2241 GCTCTATTTCTAACTAAATTCTATTTATGTAACAACACAGCTAATTTACTCTTGGATCTCATTCTCCCTTTTTATCCTGA 2321 GTTACCATCAGTGCTAATGTTCCTCTTTTGGGTATAGTTCTCCAGGAGAACTTGTCCTATATTTCTTTGTGTGTGTTTTT 2401 TTCCTTCCAGCTTAAACAAATTAAAACTAAATATCTAAACCTTGTATACAGACATTAAAATTAGTGAGAGAAACAAAATA 2481 TCCTTGTGTCTTGGCTTTTACTTTTTGAAGTCATTAACAAATAATAAATTAATGAATAAAATGTGTCCTTATTATGTTTT 2561 CCTTGTTTGTAGTTACAGCTATATTTTTATCATATTAACATTTTTCACTTAACTTCGTAATGAACTTATGGCATTTCACA 2641 CTTACTCGAAACCATAATATAATTATTATTGGTGGTATTACTGTTTGGTTTTTACTATTTTTACTCAAAAACATAAAACT 2721 TCACCATTCTTTCCATTTTCATTTGCCCCTTTATTCTTTCTGACTTTTCTCTAAGCCTGCATAGGAGCTTTATTCTCATA 2801 TTCAATAGGATAGGATATTGCAGTCTCATCCTGTTTTCTGCTGTCCTGCACCATTAAATTTTATATGTCCTTGAAGGAAT 2881 TCAATTTAATGGCAACTAATATATGTATGTTAGGGACAGGTAAAGAGTCTGTGACTGAGATTTCTGGAGTTATATAACCC 2961 CTGCGCCACCCCCCACCCCAACTCCAACTTGCCAGAATTCACCCCTTAACCTGCAATGTGATTGTATTTGGACATAGGGC 3041 AATGAGGACATAAGAATGTGATTCTAATTTGATACAAATGGTGATCTTATGAGAAGAGGAAGGAGAGACGTCTCTTCCTA 3121 TGCTCACACACAAAGGAAAGTCCACATGAGGACACAAGGAGAAGCCAAGAGAGCCCTTACCAGGAATTAAACCTGCTAAT 3201 CCCTATTTTAATTAGAACAGTGAGAAAATAAATATCTGTATTTAAGCCTCAAAAAAAAAAAAAAAA Target sites
Provided by authors
Predicted by miRanda
DRVs
SNPs
DRVs & SNPs
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miRNA-target interactions (Predicted by miRanda) |
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DRVs in gene 3'UTRs | |||||||||||||||||||||
SNPs in gene 3'UTRs |
Experimental Support 1 for Functional miRNA-Target Interaction | |||||||
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miRNA:Target | ---- | ||||||
Validation Method |
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Conditions | HEK293 | ||||||
Disease | 57711.0 | ||||||
Location of target site | 3'UTR | ||||||
Tools used in this research | TargetScan , miRTarCLIP , Piranha | ||||||
Original Description (Extracted from the article) |
...
"HITS-CLIP data was present in GSM714643. RNA binding protein: AGO2. Condition:completeT1
... - Kishore S; Jaskiewicz L; Burger L; Hausser et al., 2011, Nature methods. |
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miRNA-target interactions (Provided by authors) |
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Article |
- Kishore S; Jaskiewicz L; Burger L; Hausser et al. - Nature methods, 2011
Cross-linking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins. We developed a method for CLIP data analysis, and applied it to compare CLIP with photoactivatable ribonucleoside-enhanced CLIP (PAR-CLIP) and to uncover how differences in cross-linking and ribonuclease digestion affect the identified sites. We found only small differences in accuracies of these methods in identifying binding sites of HuR, which binds low-complexity sequences, and Argonaute 2, which has a complex binding specificity. We found that cross-link-induced mutations led to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites. This bias can be substantially reduced by milder nuclease digestion conditions.
LinkOut: [PMID: 21572407]
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Experimental Support 2 for Functional miRNA-Target Interaction | |||||||
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miRNA:Target | ---- | ||||||
Validation Method |
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Conditions | Hela | ||||||
Location of target site | 3'UTR | ||||||
Tools used in this research | TargetScan , miRTarCLIP , Piranha | ||||||
Original Description (Extracted from the article) |
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HITS-CLIP data was present in GSM1048187. RNA binding protein: AGO2. Condition:Hela_AGO2_CLIP_control
... - Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al., 2013, Cell. |
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miRNA-target interactions (Provided by authors) |
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Article |
- Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al. - Cell, 2013
The induction of pluripotency or trans-differentiation of one cell type to another can be accomplished with cell-lineage-specific transcription factors. Here, we report that repression of a single RNA binding polypyrimidine-tract-binding (PTB) protein, which occurs during normal brain development via the action of miR-124, is sufficient to induce trans-differentiation of fibroblasts into functional neurons. Besides its traditional role in regulated splicing, we show that PTB has a previously undocumented function in the regulation of microRNA functions, suppressing or enhancing microRNA targeting by competitive binding on target mRNA or altering local RNA secondary structure. A key event during neuronal induction is the relief of PTB-mediated blockage of microRNA action on multiple components of the REST complex, thereby derepressing a large array of neuronal genes, including miR-124 and multiple neuronal-specific transcription factors, in nonneuronal cells. This converts a negative feedback loop to a positive one to elicit cellular reprogramming to the neuronal lineage.
LinkOut: [PMID: 23313552]
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CLIP-seq Support 1 for dataset GSM714643 | |
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Method / RBP | HITS-CLIP / AGO2 |
Cell line / Condition | HEK293 / completeT1, repB |
Location of target site | ENST00000334116.7 | 3UTR | CACAUGCACUACAUAACACACUAUAUAUAUAUAUAUAUAU |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 21572407 / GSE28865 |
CLIP-seq Viewer | Link |
CLIP-seq Support 2 for dataset GSM1048187 | |
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Method / RBP | HITS-CLIP / AGO2 |
Cell line / Condition | Hela / Hela_AGO2_CLIP_control |
Location of target site | ENST00000334116.7 | 3UTR | ACAUGCACUACAUAACACACUAUAUAUAUAUAUAUAU |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 23313552 / GSE42701 |
CLIP-seq Viewer | Link |
MiRNA-Target Expression Profile | |||||||
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MiRNA-Target Expression Profile (TCGA) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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70 hsa-miR-3911 Target Genes:
Functional analysis:
ID![]() |
Target | Description | Validation methods |
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Strong evidence | Less strong evidence | |||||||||||
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MIRT207399 | MAT2A | methionine adenosyltransferase 2A | ![]() |
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2 | 6 | ||||||
MIRT284537 | PDP2 | pyruvate dehyrogenase phosphatase catalytic subunit 2 | ![]() |
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2 | 2 | ||||||
MIRT291946 | TPM4 | tropomyosin 4 | ![]() |
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2 | 2 | ||||||
MIRT293609 | PVR | poliovirus receptor | ![]() |
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2 | 2 | ||||||
MIRT357688 | PAIP2 | poly(A) binding protein interacting protein 2 | ![]() |
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2 | 2 | ||||||
MIRT451607 | MEIS3P1 | Meis homeobox 3 pseudogene 1 | ![]() |
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2 | 2 | ||||||
MIRT452110 | IFITM1 | interferon induced transmembrane protein 1 | ![]() |
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2 | 2 | ||||||
MIRT457804 | KLHL25 | kelch like family member 25 | ![]() |
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2 | 2 | ||||||
MIRT462730 | EFNB1 | ephrin B1 | ![]() |
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2 | 2 | ||||||
MIRT463219 | ZNF131 | zinc finger protein 131 | ![]() |
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2 | 2 | ||||||
MIRT464141 | VPS28 | VPS28, ESCRT-I subunit | ![]() |
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2 | 2 | ||||||
MIRT467582 | SLC7A5 | solute carrier family 7 member 5 | ![]() |
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2 | 6 | ||||||
MIRT470824 | PLXND1 | plexin D1 | ![]() |
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2 | 2 | ||||||
MIRT474230 | LCLAT1 | lysocardiolipin acyltransferase 1 | ![]() |
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2 | 2 | ||||||
MIRT478989 | COLGALT1 | collagen beta(1-O)galactosyltransferase 1 | ![]() |
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2 | 2 | ||||||
MIRT479462 | CDK6 | cyclin dependent kinase 6 | ![]() |
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2 | 2 | ||||||
MIRT483558 | SYT2 | synaptotagmin 2 | ![]() |
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2 | 2 | ||||||
MIRT484483 | SLC9A1 | solute carrier family 9 member A1 | ![]() |
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2 | 2 | ||||||
MIRT485224 | PRICKLE1 | prickle planar cell polarity protein 1 | ![]() |
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2 | 2 | ||||||
MIRT490356 | DPYSL5 | dihydropyrimidinase like 5 | ![]() |
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2 | 4 | ||||||
MIRT493177 | MKNK2 | MAP kinase interacting serine/threonine kinase 2 | ![]() |
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2 | 2 | ||||||
MIRT509802 | CHAF1B | chromatin assembly factor 1 subunit B | ![]() |
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2 | 4 | ||||||
MIRT511815 | HDGF | heparin binding growth factor | ![]() |
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2 | 2 | ||||||
MIRT512254 | ARPP19 | cAMP regulated phosphoprotein 19 | ![]() |
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2 | 6 | ||||||
MIRT513025 | GPT2 | glutamic--pyruvic transaminase 2 | ![]() |
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2 | 2 | ||||||
MIRT519640 | ZNF772 | zinc finger protein 772 | ![]() |
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2 | 4 | ||||||
MIRT531178 | SIGLEC12 | sialic acid binding Ig like lectin 12 (gene/pseudogene) | ![]() |
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2 | 2 | ||||||
MIRT537870 | EDA2R | ectodysplasin A2 receptor | ![]() |
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2 | 2 | ||||||
MIRT551914 | IGLON5 | IgLON family member 5 | ![]() |
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2 | 2 | ||||||
MIRT558359 | DMTF1 | cyclin D binding myb like transcription factor 1 | ![]() |
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2 | 2 | ||||||
MIRT559771 | URGCP-MRPS24 | URGCP-MRPS24 readthrough | ![]() |
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2 | 4 | ||||||
MIRT559813 | ZNF83 | zinc finger protein 83 | ![]() |
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2 | 2 | ||||||
MIRT561999 | LPP | LIM domain containing preferred translocation partner in lipoma | ![]() |
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2 | 2 | ||||||
MIRT565754 | SERTAD2 | SERTA domain containing 2 | ![]() |
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2 | 2 | ||||||
MIRT569423 | DCAF8 | DDB1 and CUL4 associated factor 8 | ![]() |
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2 | 2 | ||||||
MIRT569845 | RGS5 | regulator of G protein signaling 5 | ![]() |
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2 | 2 | ||||||
MIRT606928 | CDK15 | cyclin dependent kinase 15 | ![]() |
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2 | 2 | ||||||
MIRT607616 | TMEM130 | transmembrane protein 130 | ![]() |
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2 | 4 | ||||||
MIRT607629 | TRIOBP | TRIO and F-actin binding protein | ![]() |
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2 | 2 | ||||||
MIRT607885 | SATB1 | SATB homeobox 1 | ![]() |
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2 | 2 | ||||||
MIRT607942 | SSX2 | SSX family member 2 | ![]() |
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2 | 4 | ||||||
MIRT608017 | CARNS1 | carnosine synthase 1 | ![]() |
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2 | 4 | ||||||
MIRT608036 | UBLCP1 | ubiquitin like domain containing CTD phosphatase 1 | ![]() |
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2 | 2 | ||||||
MIRT608063 | SSX2B | SSX family member 2B | ![]() |
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2 | 4 | ||||||
MIRT608558 | SBK1 | SH3 domain binding kinase 1 | ![]() |
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2 | 6 | ||||||
MIRT608915 | NCDN | neurochondrin | ![]() |
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2 | 6 | ||||||
MIRT615876 | HIF1AN | hypoxia inducible factor 1 alpha subunit inhibitor | ![]() |
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2 | 4 | ||||||
MIRT618023 | ELFN1 | extracellular leucine rich repeat and fibronectin type III domain containing 1 | ![]() |
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2 | 2 | ||||||
MIRT620505 | SNRPD1 | small nuclear ribonucleoprotein D1 polypeptide | ![]() |
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2 | 2 | ||||||
MIRT628101 | IL1RAPL1 | interleukin 1 receptor accessory protein like 1 | ![]() |
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2 | 2 | ||||||
MIRT628700 | ZNF548 | zinc finger protein 548 | ![]() |
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2 | 2 | ||||||
MIRT630658 | POU2F1 | POU class 2 homeobox 1 | ![]() |
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2 | 2 | ||||||
MIRT643508 | ZNF28 | zinc finger protein 28 | ![]() |
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2 | 2 | ||||||
MIRT646379 | SLC22A6 | solute carrier family 22 member 6 | ![]() |
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2 | 2 | ||||||
MIRT660041 | C15orf61 | chromosome 15 open reading frame 61 | ![]() |
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2 | 2 | ||||||
MIRT687700 | KRR1 | KRR1, small subunit processome component homolog | ![]() |
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2 | 2 | ||||||
MIRT688858 | CAMKK2 | calcium/calmodulin dependent protein kinase kinase 2 | ![]() |
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2 | 2 | ||||||
MIRT690443 | REPIN1 | replication initiator 1 | ![]() |
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2 | 2 | ||||||
MIRT690456 | ZNF33A | zinc finger protein 33A | ![]() |
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2 | 2 | ||||||
MIRT693796 | RHOG | ras homolog family member G | ![]() |
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2 | 2 | ||||||
MIRT694274 | ZNF529 | zinc finger protein 529 | ![]() |
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2 | 4 | ||||||
MIRT697697 | WAC | WW domain containing adaptor with coiled-coil | ![]() |
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2 | 2 | ||||||
MIRT700242 | RCC2 | regulator of chromosome condensation 2 | ![]() |
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2 | 2 | ||||||
MIRT701836 | MRPL37 | mitochondrial ribosomal protein L37 | ![]() |
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2 | 2 | ||||||
MIRT704255 | DHCR24 | 24-dehydrocholesterol reductase | ![]() |
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2 | 2 | ||||||
MIRT707203 | SDK2 | sidekick cell adhesion molecule 2 | ![]() |
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2 | 2 | ||||||
MIRT710365 | CREB5 | cAMP responsive element binding protein 5 | ![]() |
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2 | 2 | ||||||
MIRT711943 | WDFY1 | WD repeat and FYVE domain containing 1 | ![]() |
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2 | 2 | ||||||
MIRT715496 | MAZ | MYC associated zinc finger protein | ![]() |
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2 | 2 | ||||||
MIRT719250 | MS4A1 | membrane spanning 4-domains A1 | ![]() |
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2 | 2 |
miRNA-Drug Associations | ||||||||||||||||||
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miRNA-Drug Resistance Associations | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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