miRTarBase - #MIRT694437


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pre-miRNA Information
pre-miRNA hsa-mir-367   
Genomic Coordinates chr4: 112647874 - 112647941
Synonyms MIRN367, hsa-mir-367, MIR367
Description Homo sapiens miR-367 stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-367-3p
Sequence 44| AAUUGCACUUUAGCAAUGGUGA |65
Evidence Experimental
Experiments Cloned
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN24411246 17 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs535597757 1 dbSNP
rs1013348949 11 dbSNP
rs896333735 12 dbSNP
rs751269136 14 dbSNP
rs1163501507 16 dbSNP
rs757092597 21 dbSNP
Putative Targets

Gene Information
Gene Symbol MCF2L2   
Synonyms ARHGEF22
Description MCF.2 cell line derived transforming sequence-like 2
Transcript NM_015078   
Expression
Putative miRNA Targets on MCF2L2
3'UTR of MCF2L2
(miRNA target sites are highlighted)		 
>MCF2L2|NM_015078|3'UTR
   1 CCTCCCTGCGGACGCCCCCGCTCCTCGGCTCCAGAGCGCCCGCATTCCCGGGAGAGGCGGTGTGGGGGCCCGGGCCCTGC
  81 CCAGCTACGCAGAAAGCAGCCGGAGCCTCGGCGGCGGCAGAAAGGGGACAACCAGGGCCTCCTCCGAGGAGCCCGAGGGG
 161 TGTCCTGGGTGCGCGCCTAGCTCCGCACGGGGGACCTCGGAGCTGCTCTAAGGCGCCTGCAGAGGCGAGCAGAGCCCGCA
 241 GCCCACGCCTTCTCGACCGCGCACTTCGACATTCGGAGCCGGGCAATTCTTTGCTGCGTGGGCTTCTCTGTGCTCCCACG
 321 GTAGGATGTTTAGTAGCACCCCTGGCCTCTACCCACTAGGTGCCAGGAATGCGCCACCCCATCCTCCACCCCGCCCCCAA
 401 ATCGTGACAATCAAAAATGCCTGCAGACACGCCCGCATTTCTCCAGGGCGGGGTGGGAATCGGTTGAGAGCCGCTTAGCC
 481 CGAGCCTTGGAGGAGCCGGAGCCGCTCAAACCCGGCGGGGGCCGCAGACTGGGAGCTCCCGGTCCGCCTCCCAGCATCCC
 561 TGCGAGCGTTCATGGGGTGTTCGTGTTAGTGCCAAGATTGCTTCGTTGTAGAGAGAGTTCGTTCCAAGTTACTTTCTGAG
 641 GTATTTTATGTATCGATTTATTAGTTTTTAAATGAGTTTTGTTAGTTTCAGTTGTATTTTATTTTTAGTTTTATTAGTTG
 721 ATTTTCATTTCTTTGTAGCTTTCTGGTTATTTAATTTTATAGTTTCAGTTACTGGTTTATAGTTACTTTATTTTCAAAGT
 801 TATTTAGTTGTTCATTTTCAGTTATTTATATGTAGTTGTTTTGTTTTAGGAGTTACAGATGTTCAAATTAATTTGCTTGG
 881 AATTTATTTATTTATTTATTTATTTATTTTTCGAGACGGAGTCTCGCTCTGTCGCCCAGGCTGGAGTGCAGTGGTGTGAT
 961 CTCGGCTCACTGCAAACCGCCTCCCGGGTTCACGCCATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGACTACAGGCGCC
1041 CGCCACCACGCCCGGCTAATTTTTTATTTGGATTTTTAGTAGAGACGGGGTTTCCCCGTGTTAGCCAGGATGGTCTCGAT
1121 CTCCTGACCTCGTGATCCCCCTGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGCGCCCAGCCGGAAT
1201 TTATTTTTAATTATCTTTACAATTATTATCTGAGTTATTTACCTTCATAGTTATTTCACTTTATCTTATTGGAGTTTTTG
1281 AGTTATTTATTTTTACAGTAACTTATTTGACTATTAAACACTCACTGGAAGTTCATGAACTACTGTCAAGTTATTTATTT
1361 TCAGAGTGAAATGTTT
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' aguGGUAACGAUUUCACGUUAa 5'
             |||  |||::||||||:| 
Target 5' cgcCCA-GGCTGGAGTGCAGTg 3'
 933 - 953 150.00 -21.30
2 
miRNA  3' agugGUAACGAUUU--CACGUUAa 5'
              |||| | :|:  | ||||| 
Target 5' tcgaCATT-CGGAGCCGGGCAATt 3'
 266 - 288 119.00 -7.90
3 
miRNA  3' aguGGUAACGAUUU--CAC-GUUAa 5'
             ||:   | |||  ||| |||| 
Target 5' accCCGCCCCCAAATCGTGACAATc 3'
 388 - 412 117.00 -6.03
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30533967 2 COSMIC
COSN9538598 15 COSMIC
COSN20040811 37 COSMIC
COSN30513165 42 COSMIC
COSN1935640 58 COSMIC
COSN22020027 126 COSMIC
COSN14985190 198 COSMIC
COSN20099438 882 COSMIC
COSN6757268 917 COSMIC
COSN9538597 964 COSMIC
COSN9538596 1195 COSMIC
COSN9538595 1262 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1274065057 1 dbSNP
rs746933877 1 dbSNP
rs1035424103 4 dbSNP
rs1225026307 5 dbSNP
rs778723482 7 dbSNP
rs1255767586 9 dbSNP
rs1188837638 12 dbSNP
rs999521642 12 dbSNP
rs1198756744 13 dbSNP
rs902527214 14 dbSNP
rs757012258 15 dbSNP
rs753609893 17 dbSNP
rs1043759152 19 dbSNP
rs1480866413 20 dbSNP
rs1250647093 22 dbSNP
rs1178768492 23 dbSNP
rs1010960499 25 dbSNP
rs183261612 26 dbSNP
rs755987110 27 dbSNP
rs1398499741 29 dbSNP
rs1385072738 31 dbSNP
rs1322630748 37 dbSNP
rs1273285177 38 dbSNP
rs1232215307 41 dbSNP
rs1338333596 42 dbSNP
rs1406580387 48 dbSNP
rs752676290 51 dbSNP
rs1275863602 53 dbSNP
rs1316976810 58 dbSNP
rs944942714 59 dbSNP
rs1252622695 63 dbSNP
rs531985902 68 dbSNP
rs1208517903 69 dbSNP
rs148060431 69 dbSNP
rs779984579 70 dbSNP
rs1490603630 72 dbSNP
rs1202070105 75 dbSNP
rs565148013 82 dbSNP
rs928921396 84 dbSNP
rs920270410 96 dbSNP
rs191585219 100 dbSNP
rs1366141181 101 dbSNP
rs1419267644 102 dbSNP
rs1426296704 104 dbSNP
rs1296162708 105 dbSNP
rs1339442121 108 dbSNP
rs1382493416 113 dbSNP
rs1297296034 116 dbSNP
rs1338123792 124 dbSNP
rs1187818276 127 dbSNP
rs969857775 128 dbSNP
rs1291627336 130 dbSNP
rs1360852245 131 dbSNP
rs915718536 132 dbSNP
rs368542505 136 dbSNP
rs574042276 140 dbSNP
rs1474303701 144 dbSNP
rs960227231 148 dbSNP
rs1264164959 149 dbSNP
rs1422085394 151 dbSNP
rs1183122052 162 dbSNP
rs1385757242 164 dbSNP
rs1446443967 166 dbSNP
rs560954253 170 dbSNP
rs1359599251 171 dbSNP
rs542327605 175 dbSNP
rs758539404 183 dbSNP
rs1480409870 188 dbSNP
rs1399637525 191 dbSNP
rs575026430 193 dbSNP
rs966654119 194 dbSNP
rs1248870974 195 dbSNP
rs1335205054 196 dbSNP
rs1005073748 208 dbSNP
rs1316628809 209 dbSNP
rs1292669517 214 dbSNP
rs1262693861 215 dbSNP
rs1022273297 221 dbSNP
rs1203113113 227 dbSNP
rs1243887075 236 dbSNP
rs1010931082 237 dbSNP
rs1351813557 239 dbSNP
rs375918251 240 dbSNP
rs1288356557 243 dbSNP
rs765491632 245 dbSNP
rs1390493109 249 dbSNP
rs1375540591 254 dbSNP
rs1465289999 255 dbSNP
rs1370663461 258 dbSNP
rs1294897717 260 dbSNP
rs1459804741 263 dbSNP
rs1443940827 264 dbSNP
rs1329850691 269 dbSNP
rs620722 270 dbSNP
rs541389520 271 dbSNP
rs1309695692 283 dbSNP
rs1310653735 284 dbSNP
rs1009025692 290 dbSNP
rs1263996507 293 dbSNP
rs577175890 297 dbSNP
rs900670265 298 dbSNP
rs559168812 303 dbSNP
rs1232210867 307 dbSNP
rs1480941519 309 dbSNP
rs1178721903 310 dbSNP
rs1265070640 319 dbSNP
rs1479993829 327 dbSNP
rs1176619538 331 dbSNP
rs1431012776 332 dbSNP
rs1414278888 337 dbSNP
rs111877566 339 dbSNP
rs537363761 341 dbSNP
rs1443639375 346 dbSNP
rs570207461 347 dbSNP
rs890448595 348 dbSNP
rs796934457 349 dbSNP
rs945270973 358 dbSNP
rs1418560193 367 dbSNP
rs1325981904 378 dbSNP
rs1037400879 391 dbSNP
rs71314290 392 dbSNP
rs1272462854 394 dbSNP
rs948468169 398 dbSNP
rs1206463396 406 dbSNP
rs915702121 412 dbSNP
rs992991392 420 dbSNP
rs1193137031 422 dbSNP
rs938497246 424 dbSNP
rs924463487 429 dbSNP
rs1476675893 430 dbSNP
rs1272249727 434 dbSNP
rs564577308 436 dbSNP
rs1419534409 441 dbSNP
rs915194674 443 dbSNP
rs41460044 445 dbSNP
rs1173116946 450 dbSNP
rs1331080733 451 dbSNP
rs1424397575 453 dbSNP
rs554908465 455 dbSNP
rs1347615297 459 dbSNP
rs1237763370 481 dbSNP
rs761038564 485 dbSNP
rs541720921 488 dbSNP
rs1310426474 492 dbSNP
rs1441163768 497 dbSNP
rs1358695857 500 dbSNP
rs981874010 503 dbSNP
rs619424 508 dbSNP
rs908215668 511 dbSNP
rs1017654834 512 dbSNP
rs1242371054 513 dbSNP
rs1391539597 517 dbSNP
rs555518181 518 dbSNP
rs952391926 521 dbSNP
rs147923924 523 dbSNP
rs1362123414 524 dbSNP
rs1367784457 526 dbSNP
rs1178523689 528 dbSNP
rs547102033 530 dbSNP
rs1399325860 532 dbSNP
rs1454823239 533 dbSNP
rs531948764 538 dbSNP
rs964878767 550 dbSNP
rs1346033251 558 dbSNP
rs571178775 564 dbSNP
rs1191461383 567 dbSNP
rs1466070310 572 dbSNP
rs1262388704 573 dbSNP
rs1018217963 575 dbSNP
rs1008966058 577 dbSNP
rs148741957 582 dbSNP
rs769613051 588 dbSNP
rs1020957715 590 dbSNP
rs1207405838 599 dbSNP
rs1242047958 602 dbSNP
rs1346651247 610 dbSNP
rs1184678409 611 dbSNP
rs1300783735 615 dbSNP
rs894142822 621 dbSNP
rs1328562425 622 dbSNP
rs1009535596 625 dbSNP
rs1334985635 627 dbSNP
rs1405357452 629 dbSNP
rs186629855 630 dbSNP
rs1382887707 631 dbSNP
rs144266575 633 dbSNP
rs1333961160 636 dbSNP
rs1441173789 640 dbSNP
rs542888525 641 dbSNP
rs937956624 648 dbSNP
rs947301527 650 dbSNP
rs905009604 652 dbSNP
rs1262126795 658 dbSNP
rs1383193070 666 dbSNP
rs1323570215 679 dbSNP
rs914448956 683 dbSNP
rs1245485289 688 dbSNP
rs1436649096 691 dbSNP
rs975742154 694 dbSNP
rs1233754021 696 dbSNP
rs1046254840 707 dbSNP
rs1174504310 714 dbSNP
rs949132354 716 dbSNP
rs1373413471 719 dbSNP
rs908266814 720 dbSNP
rs768350771 727 dbSNP
rs1445138545 733 dbSNP
rs1394240135 735 dbSNP
rs1390804691 749 dbSNP
rs1257691314 754 dbSNP
rs1162407501 755 dbSNP
rs6771207 756 dbSNP
rs200464888 758 dbSNP
rs373787665 758 dbSNP
rs1277835112 759 dbSNP
rs1345806019 762 dbSNP
rs1224778057 775 dbSNP
rs1230146433 780 dbSNP
rs527361018 782 dbSNP
rs559842059 797 dbSNP
rs35110796 799 dbSNP
rs954805036 805 dbSNP
rs1195665370 809 dbSNP
rs965355777 830 dbSNP
rs1274363142 841 dbSNP
rs1026477587 848 dbSNP
rs758309561 848 dbSNP
rs1268414249 855 dbSNP
rs987671064 856 dbSNP
rs899334773 860 dbSNP
rs1201666360 861 dbSNP
rs1371345934 864 dbSNP
rs1461545965 867 dbSNP
rs1179769156 872 dbSNP
rs1016483291 876 dbSNP
rs1398574142 882 dbSNP
rs1325149995 890 dbSNP
rs1302350947 892 dbSNP
rs954865005 900 dbSNP
rs1415519734 904 dbSNP
rs1021010041 906 dbSNP
rs1311352203 908 dbSNP
rs1411808474 909 dbSNP
rs1211786463 910 dbSNP
rs3056448 910 dbSNP
rs398063085 910 dbSNP
rs1057227357 912 dbSNP
rs1236374352 912 dbSNP
rs138676517 912 dbSNP
rs938434048 912 dbSNP
rs1194055554 913 dbSNP
rs902978226 915 dbSNP
rs879611048 922 dbSNP
rs1041448642 925 dbSNP
rs1162868233 926 dbSNP
rs1385562247 933 dbSNP
rs1474396597 936 dbSNP
rs1009669415 940 dbSNP
rs893796598 941 dbSNP
rs1383859158 944 dbSNP
rs1032783767 945 dbSNP
rs1319800127 951 dbSNP
rs577138594 955 dbSNP
rs558706810 957 dbSNP
rs1046306796 963 dbSNP
rs1247468186 965 dbSNP
rs544086847 972 dbSNP
rs576714344 979 dbSNP
rs1195637160 986 dbSNP
rs1249917151 987 dbSNP
rs987911952 990 dbSNP
rs1182871860 991 dbSNP
rs745986825 993 dbSNP
rs554848156 994 dbSNP
rs1385813088 997 dbSNP
rs931084302 1007 dbSNP
rs1425316167 1010 dbSNP
rs536409449 1014 dbSNP
rs975521786 1015 dbSNP
rs1357898423 1017 dbSNP
rs1291583115 1018 dbSNP
rs1275671672 1026 dbSNP
rs1234423343 1031 dbSNP
rs1354913469 1037 dbSNP
rs1291440858 1038 dbSNP
rs41319644 1041 dbSNP
rs1159950348 1042 dbSNP
rs1403180179 1043 dbSNP
rs1451314431 1044 dbSNP
rs910771812 1047 dbSNP
rs1398123155 1049 dbSNP
rs1350952043 1050 dbSNP
rs1316541420 1053 dbSNP
rs1239953193 1054 dbSNP
rs987723617 1055 dbSNP
rs963512150 1056 dbSNP
rs553423869 1060 dbSNP
rs1013152726 1062 dbSNP
rs1484235723 1065 dbSNP
rs370628681 1068 dbSNP
rs538373948 1071 dbSNP
rs988207558 1075 dbSNP
rs1419455198 1078 dbSNP
rs568595583 1078 dbSNP
rs958404957 1082 dbSNP
rs1032336869 1087 dbSNP
rs1415064218 1088 dbSNP
rs1002581988 1094 dbSNP
rs969419873 1095 dbSNP
rs1407468755 1096 dbSNP
rs1296963875 1097 dbSNP
rs113717032 1098 dbSNP
rs1343919992 1099 dbSNP
rs1222983520 1100 dbSNP
rs1263897920 1103 dbSNP
rs1314040055 1108 dbSNP
rs1202272767 1114 dbSNP
rs902863726 1117 dbSNP
rs549551401 1118 dbSNP
rs1231991872 1121 dbSNP
rs1179216465 1126 dbSNP
rs1426587863 1129 dbSNP
rs1426252574 1147 dbSNP
rs377442088 1153 dbSNP
rs1354519270 1154 dbSNP
rs1013468151 1157 dbSNP
rs1430771794 1159 dbSNP
rs1310313971 1162 dbSNP
rs1011299036 1164 dbSNP
rs886928160 1176 dbSNP
rs1404507387 1178 dbSNP
rs567400962 1185 dbSNP
rs995264706 1186 dbSNP
rs898271255 1187 dbSNP
rs1212901986 1188 dbSNP
rs1165320802 1190 dbSNP
rs1308043985 1192 dbSNP
rs549307338 1194 dbSNP
rs942319713 1195 dbSNP
rs1289398846 1196 dbSNP
rs1490128511 1197 dbSNP
rs1334719742 1199 dbSNP
rs1222722517 1219 dbSNP
rs912248805 1222 dbSNP
rs1052005025 1225 dbSNP
rs933585338 1230 dbSNP
rs1185472024 1236 dbSNP
rs757275469 1241 dbSNP
rs187035229 1244 dbSNP
rs1450706341 1248 dbSNP
rs1171053967 1252 dbSNP
rs1225582278 1253 dbSNP
rs1424456338 1262 dbSNP
rs988752062 1296 dbSNP
rs1324390039 1297 dbSNP
rs1351882047 1302 dbSNP
rs1428682516 1307 dbSNP
rs1288432546 1311 dbSNP
rs942624131 1314 dbSNP
rs1230444051 1320 dbSNP
rs1312838324 1337 dbSNP
rs1358403552 1339 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions Hela
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1048187. RNA binding protein: AGO2. Condition:Hela_AGO2_CLIP_control ...

- Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al., 2013, Cell.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' agUGGUAACGAUUUCACGUUAa 5'
            |||   |||::||||||:| 
Target 5' ucACCCAGGCUGGAGUGCAGUg 3'
 		9 - 30
Article - Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al.
- Cell, 2013
The induction of pluripotency or trans-differentiation of one cell type to another can be accomplished with cell-lineage-specific transcription factors. Here, we report that repression of a single RNA binding polypyrimidine-tract-binding (PTB) protein, which occurs during normal brain development via the action of miR-124, is sufficient to induce trans-differentiation of fibroblasts into functional neurons. Besides its traditional role in regulated splicing, we show that PTB has a previously undocumented function in the regulation of microRNA functions, suppressing or enhancing microRNA targeting by competitive binding on target mRNA or altering local RNA secondary structure. A key event during neuronal induction is the relief of PTB-mediated blockage of microRNA action on multiple components of the REST complex, thereby derepressing a large array of neuronal genes, including miR-124 and multiple neuronal-specific transcription factors, in nonneuronal cells. This converts a negative feedback loop to a positive one to elicit cellular reprogramming to the neuronal lineage.
LinkOut: [PMID: 23313552]
CLIP-seq Support 1 for dataset GSM1048187
Method / RBP HITS-CLIP / AGO2
Cell line / Condition Hela / Hela_AGO2_CLIP_control
Location of target site ENST00000328913.3 | 3UTR | UCUCUCUGUCACCCAGGCUGGAGUGCAGUGG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23313552 / GSE42701
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE28544 Breast cancer -0.74 1.8e-5 -0.786 2.7e-6 24 Click to see details
GSE28260 Renal cortex and medulla 0.873 4.9e-5 0.828 2.4e-4 13 Click to see details
GSE32688 Pancreatic cancer -0.402 1.1e-2 -0.413 9.4e-3 32 Click to see details
GSE27834 Pluripotent stem cells 0.46 3.7e-2 0.544 1.5e-2 16 Click to see details
GSE38974 Chronic obstructive pulmonary disease 0.276 9.1e-2 0.368 3.5e-2 25 Click to see details
GSE17306 Multiple myeloma 0.144 1.6e-1 0.507 1.0e-4 49 Click to see details
GSE21687 Ependynoma primary tumors 0.088 2.4e-1 0.115 1.8e-1 64 Click to see details
GSE26953 Aortic valvular endothelial cells -0.145 2.5e-1 0.077 3.6e-1 24 Click to see details
GSE19350 CNS germ cell tumors 0.189 2.8e-1 0.175 2.9e-1 12 Click to see details
GSE17498 Multiple myeloma -0.074 3.2e-1 0.120 2.3e-1 40 Click to see details
GSE42095 Differentiated embryonic stem cells -0.088 3.4e-1 -0.150 2.5e-1 23 Click to see details
GSE15076 Monocyte-derived dendritic cells 0.195 3.8e-1 0.200 3.7e-1 5 Click to see details
GSE21849 B cell lymphoma -0.052 3.9e-1 0.376 2.2e-2 29 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis -0.05 4.2e-1 0.072 3.8e-1 20 Click to see details
GSE14794 Lymphoblastoid cells 0.013 4.5e-1 -0.041 3.5e-1 90 Click to see details
GSE38226 Liver fibrosis 0.012 4.8e-1 -0.004 4.9e-1 21 Click to see details
GSE38226 Liver fibrosis 0.012 4.8e-1 -0.004 4.9e-1 21 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
255 hsa-miR-367-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT055315 DUSP5 dual specificity phosphatase 5 2 8
MIRT055791 PLEKHA1 pleckstrin homology domain containing A1 2 12
MIRT057114 DDIT4 DNA damage inducible transcript 4 2 4
MIRT059663 GATAD2B GATA zinc finger domain containing 2B 2 2
MIRT059926 ZDHHC5 zinc finger DHHC-type containing 5 2 2
MIRT061610 BTG2 BTG anti-proliferation factor 2 2 6
MIRT066478 HMGA2 high mobility group AT-hook 2 2 2
MIRT069388 ZFYVE21 zinc finger FYVE-type containing 21 2 2
MIRT069972 GEMIN2 gem nuclear organelle associated protein 2 2 2
MIRT074764 CNEP1R1 CTD nuclear envelope phosphatase 1 regulatory subunit 1 2 2
MIRT076199 GID4 GID complex subunit 4 homolog 2 6
MIRT077512 UBE2Z ubiquitin conjugating enzyme E2 Z 2 4
MIRT077903 TOB1 transducer of ERBB2, 1 2 6
MIRT082250 MED29 mediator complex subunit 29 2 4
MIRT082434 CIC capicua transcriptional repressor 2 6
MIRT082474 PPP1R37 protein phosphatase 1 regulatory subunit 37 2 2
MIRT082778 ZNF264 zinc finger protein 264 2 2
MIRT084533 BCL2L11 BCL2 like 11 2 8
MIRT085309 UBXN4 UBX domain protein 4 2 8
MIRT086365 SSFA2 sperm specific antigen 2 2 8
MIRT087455 NF2 neurofibromin 2 2 2
MIRT088865 FOXN2 forkhead box N2 2 12
MIRT092185 ITPR1 inositol 1,4,5-trisphosphate receptor type 1 2 6
MIRT092326 EDEM1 ER degradation enhancing alpha-mannosidase like protein 1 2 6
MIRT093533 GALNT7 polypeptide N-acetylgalactosaminyltransferase 7 2 6
MIRT096935 PAPD7 poly(A) RNA polymerase D7, non-canonical 2 8
MIRT097026 MAP1B microtubule associated protein 1B 2 4
MIRT099137 MYLIP myosin regulatory light chain interacting protein 2 6
MIRT099905 SOX4 SRY-box 4 2 12
MIRT102289 DNAJB9 DnaJ heat shock protein family (Hsp40) member B9 2 10
MIRT102507 KLHDC10 kelch domain containing 10 2 2
MIRT102891 INSIG1 insulin induced gene 1 2 2
MIRT109188 VMA21 VMA21, vacuolar ATPase assembly factor 2 4
MIRT124567 PRRC2B proline rich coiled-coil 2B 2 2
MIRT135568 SPRYD4 SPRY domain containing 4 2 2
MIRT161135 SLC25A36 solute carrier family 25 member 36 2 6
MIRT163995 KIAA1109 KIAA1109 2 4
MIRT164689 RNF4 ring finger protein 4 2 2
MIRT167705 HIVEP1 human immunodeficiency virus type I enhancer binding protein 1 2 8
MIRT178956 USP28 ubiquitin specific peptidase 28 2 2
MIRT185717 ARNTL2 aryl hydrocarbon receptor nuclear translocator like 2 2 2
MIRT186264 TCEB3 elongin A 2 2
MIRT186537 TWF1 twinfilin actin binding protein 1 2 4
MIRT186628 COX20 COX20, cytochrome c oxidase assembly factor 2 8
MIRT189373 TXLNA taxilin alpha 2 4
MIRT197013 EIF1 eukaryotic translation initiation factor 1 2 10
MIRT206437 YIPF4 Yip1 domain family member 4 2 2
MIRT211228 FGF2 fibroblast growth factor 2 2 10
MIRT214529 C5ORF24 chromosome 5 open reading frame 24 2 2
MIRT216034 IL6ST interleukin 6 signal transducer 2 10
MIRT218084 TULP4 tubby like protein 4 2 2
MIRT242418 CCDC113 coiled-coil domain containing 113 2 2
MIRT243162 SOX11 SRY-box 11 2 2
MIRT250943 CDK5R1 cyclin dependent kinase 5 regulatory subunit 1 2 4
MIRT253350 ZNF417 zinc finger protein 417 2 2
MIRT271968 ARF1 ADP ribosylation factor 1 2 2
MIRT273214 ZNF695 zinc finger protein 695 2 4
MIRT296114 SLC12A5 solute carrier family 12 member 5 2 2
MIRT301711 TEF TEF, PAR bZIP transcription factor 2 2
MIRT316477 ARID1B AT-rich interaction domain 1B 2 6
MIRT322174 CLN8 CLN8, transmembrane ER and ERGIC protein 2 4
MIRT341538 CNIH1 cornichon family AMPA receptor auxiliary protein 1 2 6
MIRT356062 SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 2 2
MIRT443579 PPIC peptidylprolyl isomerase C 2 2
MIRT448825 FKBP1A FK506 binding protein 1A 2 4
MIRT451494 FOPNL FGFR1OP N-terminal like 2 2
MIRT452694 MDM2 MDM2 proto-oncogene 2 2
MIRT453167 CNOT4 CCR4-NOT transcription complex subunit 4 2 6
MIRT454588 SLC33A1 solute carrier family 33 member 1 2 4
MIRT455794 TAF8 TATA-box binding protein associated factor 8 2 4
MIRT456010 CYP2C19 cytochrome P450 family 2 subfamily C member 19 2 2
MIRT456044 KIAA1586 KIAA1586 2 2
MIRT456763 TMEM239 transmembrane protein 239 2 4
MIRT458068 NLRP9 NLR family pyrin domain containing 9 2 2
MIRT459230 MRPS21 mitochondrial ribosomal protein S21 2 2
MIRT459534 MFF mitochondrial fission factor 2 6
MIRT459759 SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 2 2
MIRT460236 TNFRSF13C TNF receptor superfamily member 13C 2 2
MIRT461104 OPA3 OPA3, outer mitochondrial membrane lipid metabolism regulator 2 2
MIRT462924 ZNRF3 zinc and ring finger 3 2 2
MIRT463476 ZC3HAV1L zinc finger CCCH-type containing, antiviral 1 like 2 2
MIRT463516 ZBTB8B zinc finger and BTB domain containing 8B 2 4
MIRT465503 TOR1B torsin family 1 member B 2 2
MIRT469525 RBFOX2 RNA binding protein, fox-1 homolog 2 2 8
MIRT470079 PTGES2 prostaglandin E synthase 2 2 2
MIRT471581 PARD6B par-6 family cell polarity regulator beta 2 2
MIRT473451 MCOLN2 mucolipin 2 2 8
MIRT475882 H3F3C H3 histone family member 3C 2 10
MIRT475915 H3F3B H3 histone family member 3B 2 8
MIRT476195 GOLGA8A golgin A8 family member A 2 10
MIRT476318 GM2A GM2 ganglioside activator 2 2
MIRT476676 FUT11 fucosyltransferase 11 2 10
MIRT478368 DDI2 DNA damage inducible 1 homolog 2 2 2
MIRT479545 CDC5L cell division cycle 5 like 2 2
MIRT481024 BAZ2B bromodomain adjacent to zinc finger domain 2B 2 2
MIRT491009 ATF7IP activating transcription factor 7 interacting protein 2 2
MIRT493168 MKNK2 MAP kinase interacting serine/threonine kinase 2 2 2
MIRT494345 CASKIN1 CASK interacting protein 1 2 2
MIRT499087 ZDHHC21 zinc finger DHHC-type containing 21 2 6
MIRT500029 ABCF2 ATP binding cassette subfamily F member 2 2 8
MIRT501298 RRN3 RRN3 homolog, RNA polymerase I transcription factor 2 4
MIRT503124 BCL11B B-cell CLL/lymphoma 11B 2 8
MIRT503301 GTF2A1 general transcription factor IIA subunit 1 2 6
MIRT504328 ASGR2 asialoglycoprotein receptor 2 2 6
MIRT504471 EID2B EP300 interacting inhibitor of differentiation 2B 2 2
MIRT504655 RPL9 ribosomal protein L9 2 6
MIRT505331 TMF1 TATA element modulatory factor 1 2 8
MIRT505732 SERTAD3 SERTA domain containing 3 2 4
MIRT505827 RSBN1 round spermatid basic protein 1 2 8
MIRT506004 PURG purine rich element binding protein G 2 8
MIRT506308 PCMTD1 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 2 6
MIRT506806 KLHL15 kelch like family member 15 2 6
MIRT507119 GOLGA8B golgin A8 family member B 2 6
MIRT507353 FAM129A family with sequence similarity 129 member A 2 6
MIRT507591 DDX3X DEAD-box helicase 3, X-linked 2 4
MIRT507674 CPEB4 cytoplasmic polyadenylation element binding protein 4 2 4
MIRT507703 CNOT2 CCR4-NOT transcription complex subunit 2 2 8
MIRT508012 BCAT1 branched chain amino acid transaminase 1 2 4
MIRT510439 ZIC5 Zic family member 5 2 6
MIRT510539 XKR7 XK related 7 2 4
MIRT510600 TPPP tubulin polymerization promoting protein 2 6
MIRT511060 NRAS NRAS proto-oncogene, GTPase 2 4
MIRT511855 GOLGA8J golgin A8 family member J 2 6
MIRT511865 GOLGA8I golgin A8 family member I, pseudogene 1 3
MIRT512570 CTDSPL CTD small phosphatase like 2 2
MIRT512708 ZNF134 zinc finger protein 134 2 6
MIRT513177 MOAP1 modulator of apoptosis 1 2 6
MIRT513783 PAWR pro-apoptotic WT1 regulator 2 6
MIRT515099 IRGQ immunity related GTPase Q 2 2
MIRT515481 INCENP inner centromere protein 2 4
MIRT517416 BMP8A bone morphogenetic protein 8a 2 2
MIRT518754 C1orf35 chromosome 1 open reading frame 35 2 2
MIRT519780 ZNF354B zinc finger protein 354B 2 4
MIRT519865 ZFP62 ZFP62 zinc finger protein 2 6
MIRT520510 TRAM2 translocation associated membrane protein 2 2 6
MIRT521068 SLC25A32 solute carrier family 25 member 32 2 6
MIRT526912 ZNF772 zinc finger protein 772 2 6
MIRT527134 GULP1 GULP, engulfment adaptor PTB domain containing 1 2 2
MIRT527867 SLC39A14 solute carrier family 39 member 14 2 2
MIRT528404 EIF4EBP2 eukaryotic translation initiation factor 4E binding protein 2 2 2
MIRT532956 ZNF24 zinc finger protein 24 2 4
MIRT533021 ZFC3H1 zinc finger C3H1-type containing 2 4
MIRT533191 WASL Wiskott-Aldrich syndrome like 2 6
MIRT534191 SLC7A11 solute carrier family 7 member 11 2 2
MIRT534961 PTAR1 protein prenyltransferase alpha subunit repeat containing 1 2 4
MIRT536396 LCOR ligand dependent nuclear receptor corepressor 2 2
MIRT537046 GRAMD4 GRAM domain containing 4 2 2
MIRT537125 GOLGA3 golgin A3 2 4
MIRT537183 GFPT2 glutamine-fructose-6-phosphate transaminase 2 2 4
MIRT537652 ERGIC2 ERGIC and golgi 2 2 4
MIRT538632 CCSER2 coiled-coil serine rich protein 2 2 4
MIRT539231 ANP32E acidic nuclear phosphoprotein 32 family member E 2 6
MIRT540099 NPY4R neuropeptide Y receptor Y4 2 2
MIRT540998 ZNF460 zinc finger protein 460 2 4
MIRT541468 AURKA aurora kinase A 2 2
MIRT542680 SESN3 sestrin 3 2 2
MIRT542757 PRRG4 proline rich and Gla domain 4 2 2
MIRT542863 NUCKS1 nuclear casein kinase and cyclin dependent kinase substrate 1 2 2
MIRT542925 HOXC8 homeobox C8 2 2
MIRT543747 SZRD1 SUZ RNA binding domain containing 1 2 2
MIRT544404 ZSCAN12 zinc finger and SCAN domain containing 12 2 2
MIRT544583 AP5Z1 adaptor related protein complex 5 zeta 1 subunit 2 4
MIRT544662 MED19 mediator complex subunit 19 2 2
MIRT545251 GTF2E1 general transcription factor IIE subunit 1 2 2
MIRT545261 TRIM36 tripartite motif containing 36 2 4
MIRT545744 UHRF1BP1 UHRF1 binding protein 1 2 2
MIRT545999 WDR81 WD repeat domain 81 2 2
MIRT546038 VPS4B vacuolar protein sorting 4 homolog B 2 2
MIRT547170 PDZD8 PDZ domain containing 8 2 2
MIRT547273 NUFIP2 NUFIP2, FMR1 interacting protein 2 2 2
MIRT547729 KIF5B kinesin family member 5B 2 2
MIRT548127 GATA6 GATA binding protein 6 2 2
MIRT548203 FNIP1 folliculin interacting protein 1 2 2
MIRT548756 CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4 2 2
MIRT549641 ZNF75A zinc finger protein 75a 2 2
MIRT549684 ZNF598 zinc finger protein 598 2 2
MIRT550197 MRO maestro 2 2
MIRT550340 IPP intracisternal A particle-promoted polypeptide 2 2
MIRT550536 MYZAP myocardial zonula adherens protein 2 2
MIRT550975 TOR4A torsin family 4 member A 2 2
MIRT551221 CIDEC cell death inducing DFFA like effector c 2 2
MIRT551355 AGBL5 ATP/GTP binding protein like 5 2 2
MIRT551571 LETM1 leucine zipper and EF-hand containing transmembrane protein 1 2 2
MIRT552277 RAB3D RAB3D, member RAS oncogene family 2 2
MIRT552661 ZADH2 zinc binding alcohol dehydrogenase domain containing 2 2 2
MIRT553081 UCK2 uridine-cytidine kinase 2 2 2
MIRT553753 TBC1D8 TBC1 domain family member 8 2 2
MIRT554030 SPCS3 signal peptidase complex subunit 3 2 2
MIRT554099 SMU1 DNA replication regulator and spliceosomal factor 2 2
MIRT554155 SLX4 SLX4 structure-specific endonuclease subunit 2 2
MIRT554815 REL REL proto-oncogene, NF-kB subunit 2 2
MIRT555522 PMEPA1 prostate transmembrane protein, androgen induced 1 2 2
MIRT555597 PIP5K1C phosphatidylinositol-4-phosphate 5-kinase type 1 gamma 2 2
MIRT555632 PHLPP2 PH domain and leucine rich repeat protein phosphatase 2 2 4
MIRT555679 PGAM4 phosphoglycerate mutase family member 4 2 4
MIRT555827 PAX9 paired box 9 2 2
MIRT555868 PAIP1 poly(A) binding protein interacting protein 1 2 2
MIRT555939 NUP43 nucleoporin 43 2 2
MIRT555994 NFYB nuclear transcription factor Y subunit beta 2 2
MIRT556340 MAP2K4 mitogen-activated protein kinase kinase 4 2 2
MIRT556432 LONRF3 LON peptidase N-terminal domain and ring finger 3 2 2
MIRT556585 LHFPL2 LHFPL tetraspan subfamily member 2 2 4
MIRT556801 KIAA1958 KIAA1958 2 2
MIRT558047 EXOC5 exocyst complex component 5 2 2
MIRT558697 CLTA clathrin light chain A 2 2
MIRT559191 BMPR1A bone morphogenetic protein receptor type 1A 2 4
MIRT559639 AKAP10 A-kinase anchoring protein 10 2 2
MIRT559707 AEN apoptosis enhancing nuclease 2 2
MIRT560673 SRFBP1 serum response factor binding protein 1 2 2
MIRT560990 GPBP1L1 GC-rich promoter binding protein 1 like 1 2 2
MIRT562170 HOXA13 homeobox A13 2 2
MIRT562275 GNAQ G protein subunit alpha q 2 2
MIRT563624 ZNF277 zinc finger protein 277 2 2
MIRT563815 FMN1 formin 1 2 2
MIRT564096 TLR3 toll like receptor 3 2 2
MIRT565320 TMEM41A transmembrane protein 41A 2 2
MIRT565986 RNF44 ring finger protein 44 2 2
MIRT566047 REV3L REV3 like, DNA directed polymerase zeta catalytic subunit 2 2
MIRT568236 C11orf24 chromosome 11 open reading frame 24 2 2
MIRT568310 BAK1 BCL2 antagonist/killer 1 2 2
MIRT572376 ATOX1 antioxidant 1 copper chaperone 2 2
MIRT574822 CPEB3 cytoplasmic polyadenylation element binding protein 3 2 2
MIRT609212 PELP1 proline, glutamate and leucine rich protein 1 2 2
MIRT616217 RBM27 RNA binding motif protein 27 2 2
MIRT629087 FASLG Fas ligand 2 2
MIRT632124 FKBP9 FK506 binding protein 9 2 2
MIRT632576 POLQ DNA polymerase theta 2 2
MIRT634799 ENTHD1 ENTH domain containing 1 2 2
MIRT636553 ESRP1 epithelial splicing regulatory protein 1 2 2
MIRT640977 ORAI2 ORAI calcium release-activated calcium modulator 2 2 2
MIRT653875 SH2B3 SH2B adaptor protein 3 2 2
MIRT655598 OTUD7B OTU deubiquitinase 7B 2 2
MIRT659764 CCDC171 coiled-coil domain containing 171 2 2
MIRT660744 ALG14 ALG14, UDP-N-acetylglucosaminyltransferase subunit 2 2
MIRT681037 AAED1 AhpC/TSA antioxidant enzyme domain containing 1 2 2
MIRT682305 RBM28 RNA binding motif protein 28 2 2
MIRT682573 EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 2 2
MIRT686217 ZNF267 zinc finger protein 267 2 2
MIRT687209 PLXNA3 plexin A3 2 2
MIRT690630 LAX1 lymphocyte transmembrane adaptor 1 2 2
MIRT692419 AGMAT agmatinase 2 2
MIRT694437 MCF2L2 MCF.2 cell line derived transforming sequence-like 2 2 2
MIRT700725 PNO1 partner of NOB1 homolog 2 2
MIRT701549 NARF nuclear prelamin A recognition factor 2 2
MIRT704379 DAND5 DAN domain BMP antagonist family member 5 2 2
MIRT707935 PPP1R3D protein phosphatase 1 regulatory subunit 3D 2 2
MIRT709939 MRPS16 mitochondrial ribosomal protein S16 2 2
MIRT711371 MED7 mediator complex subunit 7 2 2
MIRT712327 PER2 period circadian clock 2 2 2
MIRT714515 SHE Src homology 2 domain containing E 2 2
MIRT715520 G2E3 G2/M-phase specific E3 ubiquitin protein ligase 2 2
MIRT724294 OSMR oncostatin M receptor 2 2
MIRT725358 MUC21 mucin 21, cell surface associated 2 2
MIRT732242 KLF4 Kruppel like factor 4 3 1
MIRT735384 SPAG5 sperm associated antigen 5 3 0
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-367 Medpor NULL NULL Microarray osteoblast-like cells line (MG-63) 18408260 2008 up-regulated
miR-367 Activin A NULL 229455 Quantitative real-time PCR Human embryonic stem (hES) cells 19885849 2010 up-regulated
miR-367 Mistletoe lectin-I NULL NULL Microarray colorectal cancer cells CLY cells 20955366 2011 down-regulated
miR-367 Doxorubicin approved 31703 Quantitative real-time PCR heart 22859947 2012 up-regulated
miR-367 Paclitaxel approved 36314 Microarray Ovarian cancer cell lines 24220856 2014 up-regulated
miR-367 Glucose NULL 5793 Quantitative real-time PCR endothelial cells 24394957 2014 down-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-367 Paclitaxel 36314 NSC125973 approved sensitive cell line (A2780)
hsa-miR-367-3p Doxorubicin 31703 NSC123127 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-367-3p Verapamil 2520 NSC272366 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-367-3p Siop Treatment Protocol sensitive High Nephroblastoma tissue
hsa-miR-367-3p Paclitaxel 36314 NSC125973 approved resistant High Pan-Cancer cell line (NCI-H460, NCI-H522, NCI-H322M, HOP62, A549, EKVX, MALME-3M, NCI-H226, HT-29, HCT-116, SE-620, HCT-15, HCC2998, COLO205, HS-578T, NCI/ADR-RES, OVCAR8, OVCAR4, ACHN, SN-12C, 786-O, CAKI-1, UO-31, TK-10, A498, SK-MEL-28, UACC-257, M14, UACC-62, SK
hsa-miR-367-3p Doxorubicin 31703 NSC123127 approved sensitive High Hepatocellular Carcinoma tissue and cell line (HepG2)
hsa-miR-367-3p Mitoxantrone 4212 NSC279836 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-miR-367-3p Sorafenib 216239 NSC747971 approved sensitive Low Hepatocellular Carcinoma cell line (SKhep1, HA22T)
hsa-miR-367-3p Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-miR-367-3p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM16)
hsa-miR-367-3p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM36)
hsa-miR-367-3p Sunitinib 5329102 NSC750690 approved resistant tissue (CardA)
hsa-miR-367-3p Paclitaxel 36314 NSC125973 approved sensitive cell line (SKOV3)
hsa-miR-367-3p Cisplatin 5460033 NSC119875 approved resistant cell line (IGROV-1)
hsa-miR-367-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)

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