pre-miRNA Information | |
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pre-miRNA | hsa-mir-125b-2 |
Genomic Coordinates | chr21: 16590237 - 16590325 |
Synonyms | MIRN125B2, MIR125B2 |
Description | Homo sapiens miR-125b-2 stem-loop |
Comment | This miRNA sequence is predicted based on homology to a verified miRNA from mouse . |
RNA Secondary Structure | ![]() |
Associated Diseases | ![]() |
Mature miRNA Information | |||||||||||||||
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Mature miRNA | hsa-miR-125b-2-3p | ||||||||||||||
Sequence | 54| UCACAAGUCAGGCUCUUGGGAC |75 | ||||||||||||||
Evidence | Experimental | ||||||||||||||
Experiments | Cloned | ||||||||||||||
Editing Events in miRNAs |
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SNPs in miRNA |
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Putative Targets |
miRNA Expression profile | |
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Human miRNA Tissue Atlas | |
miRNAs in Extracellular Vesicles |
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Circulating MicroRNA Expression Profiling |
Gene Information | |||||||||||||||||||||
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Gene Symbol | LRTOMT | ||||||||||||||||||||
Synonyms | CFAP111, DFNB63, LRRC51 | ||||||||||||||||||||
Description | leucine rich transmembrane and O-methyltransferase domain containing | ||||||||||||||||||||
Transcript | NM_001145308 | ||||||||||||||||||||
Other Transcripts | NM_001145307 , NM_001145309 , NM_001145310 , NM_145309 | ||||||||||||||||||||
Expression | |||||||||||||||||||||
Putative miRNA Targets on LRTOMT | |||||||||||||||||||||
3'UTR of LRTOMT (miRNA target sites are highlighted) |
>LRTOMT|NM_001145308|3'UTR 1 GGTCCAGGCCCAGGGGTACTTACTGATGCCCACCCCCACCCCCACCCAAGCAGGGACCTCAAAATCCCCTCCCTTTCCTG 81 TTTGGGGCCTTGACACACGCTGGGCTCAGGGCTAGGGAGTCTCTCTTCCCACCTCTGACCTCTTTCAGCCTCTACACTGA 161 CCTCAAGTGTCAAGTTCTATCAGGCTGCTTGGTCTCACTAGGCCCCCTCTTTCCAGAGAGAACCATGGACTGACAGCAAG 241 AAGCCTGAGCTCCCGACCCAGCTCTGTCACTGATTTGCTGAGTGACTCCAAGGGAATCCCCACCTTGCTCTGAGATTTAA 321 TCTTCTCTCTTAACACGAAGGAAGCTGGATGGGAGAGCTCCAGGGGCCTCCCAGTTCTCGGCCTCAGAAAGCCTCCCATC 401 CTCAGCCCATGCCATTCTGGGTGGGATCAGAGGAAGTGGCAATGAGTTAGACGCCCTGCAGGAATAGCTGGATGCAAGCT 481 GGGCCAGAGAAAATGGCACAGAACCCTGGACCCAGGGCCAGGGATGCCCTGGCCTTCCCTAACTCTGGCCCACCTAGCCA 561 ATTAGGTGTGGCTGATGTCCCTTGAGTGCCCTCTTCCTAAAGCCCAAAAGAAGATGCTGGACTCCTCTGGGCCCCACCAA 641 CAAATAGGGAATAGACATGGGTGGAAAATCACTCCTTTGTCTTTATTAAAGAAACTTAGACCAGACCTGGCAATCAAGGG 721 GTGAGGTACTGGCCAGGAAGGTGGAGTAGGTTTCAGGCCCTGGGGATTTCAAGTGCAGACTGATGGCCTGGGAGGGGCCA 801 AAGAGACCAGATCCTGGCAGCAGCTGAGGAGGTGCCCAAGGGCACTTTCAGGCACTGGGGCCATCAGCTGGTTCTGTGGG 881 CAGGGGTTGGGGGTTGGGATGCAGGGTAGTTTGGGCTGGCCTGGAATCTCCCTGAGGCCACCCTGCCTTGTCTACCTAGA 961 TCATCCACTGGTCCTGATCCTGTTCGTTGCCTTCCATGTCCACCTGGAGAGGAGGCTGGGTGTGGGTGGGGAGGGGCCTC 1041 AGCCAGCCTCAGCCCCAGATCCTGCCCCTGGCTGGATCCAGGGTTTCTGTACCCCTTGGCCATCAACTGGGTCAGGAGCA 1121 AGGGTCCAGGAACAGAGGCCCTCCCCCATACCCCTTGCCTACCTCATTGACCTCTCCATCATCCGGTGACTCATTGTAGT 1201 CATTCATCTCGTCCATGTCCTGCATATCCTCATCATCCTCTGAGTCCTCTTCACTATCCTCATCATCTTCATCATCCTCT 1281 TCTTCCTCGTCATCATAGTGCTGGTGGGCAGGACAGAGCCTGTAAGCCCTACAGGCCTGCATGGACCAGTTCAAGAACTG 1361 ACCCACTTGAGCCTCTCTCTAGGGCCAATGAATGACCCCCTACCCCGACACTCCCTCCTTGAGTCTAGCAGGCTGGTGCA 1441 TGTTCTGCAGGACCTTAATGCTAGGCCCAATGCCCACCCCTTCTATCTCCCCTTTTAGGCTTTTACCCAGATCTGAGAAC 1521 CACAACTGCTCTGGGTCAGAGACAGGACATTCAGAATTAGAGCAGAGCCTCGGTCCACTGCGGCCCCCACACAGGCCCCA 1601 CCTGCTAGAGCCACTCACCTCTGAGGCTGGCTTGCCAATAGGAACCAGGTTGTTGTCTTTCTCCGCGATGCTTTGGAGCT 1681 GTGGGCAAAGGCACAGAGGAACAAGGCCAGAGCCCAAGTAGGGCAGGTCAGGGGCATGGGACTGGCCCATTCTGCCCAGA 1761 AGACAACCCACACGTGTTGGGGAGAAGCTTCCTCCCAGTTCTCAGGGAGATACAATCCCTTTCTTGTCATCTGCCATTTA 1841 TGAACTTGATCCAAATAAAAAAAAAAAAAAA Target sites
Provided by authors
Predicted by miRanda
DRVs
SNPs
DRVs & SNPs
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miRNA-target interactions (Predicted by miRanda) |
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DRVs in gene 3'UTRs | |||||||||||||||||||||
SNPs in gene 3'UTRs |
Experimental Support 1 for Functional miRNA-Target Interaction | |
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miRNA:Target | ---- |
Validation Method |
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Conditions | Hela |
Location of target site | 3'UTR |
Tools used in this research | TargetScan , miRTarCLIP , Piranha |
Original Description (Extracted from the article) |
...
HITS-CLIP data was present in GSM1048187. RNA binding protein: AGO2. Condition:Hela_AGO2_CLIP_control
... - Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al., 2013, Cell. |
Article |
- Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al. - Cell, 2013
The induction of pluripotency or trans-differentiation of one cell type to another can be accomplished with cell-lineage-specific transcription factors. Here, we report that repression of a single RNA binding polypyrimidine-tract-binding (PTB) protein, which occurs during normal brain development via the action of miR-124, is sufficient to induce trans-differentiation of fibroblasts into functional neurons. Besides its traditional role in regulated splicing, we show that PTB has a previously undocumented function in the regulation of microRNA functions, suppressing or enhancing microRNA targeting by competitive binding on target mRNA or altering local RNA secondary structure. A key event during neuronal induction is the relief of PTB-mediated blockage of microRNA action on multiple components of the REST complex, thereby derepressing a large array of neuronal genes, including miR-124 and multiple neuronal-specific transcription factors, in nonneuronal cells. This converts a negative feedback loop to a positive one to elicit cellular reprogramming to the neuronal lineage.
LinkOut: [PMID: 23313552]
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CLIP-seq Support 1 for dataset GSM1048187 | |
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Method / RBP | HITS-CLIP / AGO2 |
Cell line / Condition | Hela / Hela_AGO2_CLIP_control |
Location of target site | ENST00000324866.7 | 3UTR | UUGUAUUUUUAGUAGAGACGGGGUUUCACCAUGUUAGCCAGGAUGGUCUCCAUCUCCUGACCUUGUGAUCCACCC |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 23313552 / GSE42701 |
CLIP-seq Viewer | Link |
MiRNA-Target Expression Profile | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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MiRNA-Target Expression Profile (TCGA) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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91 hsa-miR-125b-2-3p Target Genes:
Functional analysis:
ID![]() |
Target | Description | Validation methods |
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Strong evidence | Less strong evidence | |||||||||||
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MIRT038624 | HN1L | Jupiter microtubule associated homolog 2 | ![]() |
1 | 1 | |||||||
MIRT038625 | KDELC2 | KDEL motif containing 2 | ![]() |
1 | 1 | |||||||
MIRT038626 | ABHD15 | abhydrolase domain containing 15 | ![]() |
1 | 1 | |||||||
MIRT038627 | PPP1R12C | protein phosphatase 1 regulatory subunit 12C | ![]() |
1 | 1 | |||||||
MIRT038628 | MSANTD4 | Myb/SANT DNA binding domain containing 4 with coiled-coils | ![]() |
1 | 1 | |||||||
MIRT038629 | ASH2L | ASH2 like histone lysine methyltransferase complex subunit | ![]() |
1 | 1 | |||||||
MIRT038630 | USP22 | ubiquitin specific peptidase 22 | ![]() |
1 | 1 | |||||||
MIRT038631 | CSTB | cystatin B | ![]() |
1 | 1 | |||||||
MIRT038632 | SYT2 | synaptotagmin 2 | ![]() |
1 | 1 | |||||||
MIRT038633 | NDUFS7 | NADH:ubiquinone oxidoreductase core subunit S7 | ![]() |
1 | 1 | |||||||
MIRT038634 | MTA2 | metastasis associated 1 family member 2 | ![]() |
1 | 1 | |||||||
MIRT053086 | IGF1R | insulin like growth factor 1 receptor | ![]() |
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3 | 1 | |||||
MIRT055788 | PLEKHA1 | pleckstrin homology domain containing A1 | ![]() |
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2 | 12 | ||||||
MIRT061248 | AMOTL1 | angiomotin like 1 | ![]() |
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2 | 10 | ||||||
MIRT061649 | BTG2 | BTG anti-proliferation factor 2 | ![]() |
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2 | 6 | ||||||
MIRT079046 | TNRC6C | trinucleotide repeat containing 6C | ![]() |
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2 | 4 | ||||||
MIRT084583 | BCL2L11 | BCL2 like 11 | ![]() |
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2 | 8 | ||||||
MIRT093523 | GALNT7 | polypeptide N-acetylgalactosaminyltransferase 7 | ![]() |
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2 | 2 | ||||||
MIRT097383 | LHFPL2 | LHFPL tetraspan subfamily member 2 | ![]() |
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2 | 4 | ||||||
MIRT098030 | SOBP | sine oculis binding protein homolog | ![]() |
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2 | 2 | ||||||
MIRT186262 | TCEB3 | elongin A | ![]() |
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2 | 2 | ||||||
MIRT187284 | DAZAP2 | DAZ associated protein 2 | ![]() |
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2 | 10 | ||||||
MIRT361113 | LRRC1 | leucine rich repeat containing 1 | ![]() |
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2 | 2 | ||||||
MIRT443585 | FAM84B | family with sequence similarity 84 member B | ![]() |
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2 | 2 | ||||||
MIRT452249 | TRAM1 | translocation associated membrane protein 1 | ![]() |
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2 | 2 | ||||||
MIRT476289 | GMFB | glia maturation factor beta | ![]() |
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2 | 8 | ||||||
MIRT483871 | MRPL12 | mitochondrial ribosomal protein L12 | ![]() |
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2 | 2 | ||||||
MIRT484250 | ANK1 | ankyrin 1 | ![]() |
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2 | 2 | ||||||
MIRT499251 | VAV3 | vav guanine nucleotide exchange factor 3 | ![]() |
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2 | 4 | ||||||
MIRT502270 | HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | ![]() |
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2 | 4 | ||||||
MIRT504652 | RPL9 | ribosomal protein L9 | ![]() |
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2 | 6 | ||||||
MIRT505210 | UBN2 | ubinuclein 2 | ![]() |
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2 | 6 | ||||||
MIRT512690 | POP1 | POP1 homolog, ribonuclease P/MRP subunit | ![]() |
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2 | 2 | ||||||
MIRT517341 | ZNF529 | zinc finger protein 529 | ![]() |
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2 | 4 | ||||||
MIRT518946 | LSG1 | large 60S subunit nuclear export GTPase 1 | ![]() |
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2 | 2 | ||||||
MIRT520866 | SUGT1 | SGT1 homolog, MIS12 kinetochore complex assembly cochaperone | ![]() |
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2 | 2 | ||||||
MIRT521236 | SAR1A | secretion associated Ras related GTPase 1A | ![]() |
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2 | 2 | ||||||
MIRT528324 | GIGYF2 | GRB10 interacting GYF protein 2 | ![]() |
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2 | 2 | ||||||
MIRT533297 | USP46 | ubiquitin specific peptidase 46 | ![]() |
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2 | 2 | ||||||
MIRT541024 | WEE1 | WEE1 G2 checkpoint kinase | ![]() |
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2 | 4 | ||||||
MIRT544034 | ERRFI1 | ERBB receptor feedback inhibitor 1 | ![]() |
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2 | 2 | ||||||
MIRT547037 | POGZ | pogo transposable element derived with ZNF domain | ![]() |
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2 | 2 | ||||||
MIRT556102 | MOAP1 | modulator of apoptosis 1 | ![]() |
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2 | 2 | ||||||
MIRT558320 | DR1 | down-regulator of transcription 1 | ![]() |
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2 | 2 | ||||||
MIRT558520 | CSRNP3 | cysteine and serine rich nuclear protein 3 | ![]() |
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2 | 2 | ||||||
MIRT566230 | PTMA | prothymosin, alpha | ![]() |
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2 | 4 | ||||||
MIRT568437 | ARPP19 | cAMP regulated phosphoprotein 19 | ![]() |
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2 | 2 | ||||||
MIRT570584 | OTUD7B | OTU deubiquitinase 7B | ![]() |
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2 | 2 | ||||||
MIRT571384 | JKAMP | JNK1/MAPK8-associated membrane protein | ![]() |
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2 | 2 | ||||||
MIRT572798 | SIGLEC14 | sialic acid binding Ig like lectin 14 | ![]() |
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2 | 2 | ||||||
MIRT573864 | C9orf78 | chromosome 9 open reading frame 78 | ![]() |
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2 | 2 | ||||||
MIRT609930 | SLC38A1 | solute carrier family 38 member 1 | ![]() |
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2 | 4 | ||||||
MIRT610437 | CSMD2 | CUB and Sushi multiple domains 2 | ![]() |
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2 | 2 | ||||||
MIRT614407 | MURC | caveolae associated protein 4 | ![]() |
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2 | 2 | ||||||
MIRT618625 | GREB1 | growth regulation by estrogen in breast cancer 1 | ![]() |
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2 | 2 | ||||||
MIRT620605 | SAP30 | Sin3A associated protein 30 | ![]() |
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2 | 2 | ||||||
MIRT635313 | FAM179A | TOG array regulator of axonemal microtubules 2 | ![]() |
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2 | 2 | ||||||
MIRT635918 | GLTSCR2 | NOP53 ribosome biogenesis factor | ![]() |
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2 | 2 | ||||||
MIRT638507 | MAP3K9 | mitogen-activated protein kinase kinase kinase 9 | ![]() |
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2 | 2 | ||||||
MIRT640597 | TM9SF4 | transmembrane 9 superfamily member 4 | ![]() |
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2 | 2 | ||||||
MIRT644066 | IQCE | IQ motif containing E | ![]() |
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2 | 2 | ||||||
MIRT648287 | TRAPPC2L | trafficking protein particle complex 2 like | ![]() |
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2 | 2 | ||||||
MIRT653089 | SSR3 | signal sequence receptor subunit 3 | ![]() |
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2 | 2 | ||||||
MIRT654651 | PTAFR | platelet activating factor receptor | ![]() |
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2 | 2 | ||||||
MIRT658084 | FOXR2 | forkhead box R2 | ![]() |
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2 | 2 | ||||||
MIRT665306 | ZBTB37 | zinc finger and BTB domain containing 37 | ![]() |
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2 | 2 | ||||||
MIRT665974 | SYTL4 | synaptotagmin like 4 | ![]() |
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2 | 2 | ||||||
MIRT674905 | RASSF9 | Ras association domain family member 9 | ![]() |
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2 | 2 | ||||||
MIRT680085 | THAP1 | THAP domain containing 1 | ![]() |
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2 | 2 | ||||||
MIRT681487 | DIP2A | disco interacting protein 2 homolog A | ![]() |
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2 | 2 | ||||||
MIRT691243 | DFNB59 | pejvakin | ![]() |
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2 | 2 | ||||||
MIRT692361 | AGTRAP | angiotensin II receptor associated protein | ![]() |
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2 | 2 | ||||||
MIRT693034 | MB21D1 | Mab-21 domain containing 1 | ![]() |
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2 | 2 | ||||||
MIRT694478 | LRTOMT | leucine rich transmembrane and O-methyltransferase domain containing | ![]() |
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2 | 2 | ||||||
MIRT696069 | ZNF264 | zinc finger protein 264 | ![]() |
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2 | 2 | ||||||
MIRT696579 | TTC21B | tetratricopeptide repeat domain 21B | ![]() |
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2 | 2 | ||||||
MIRT696759 | MTFMT | mitochondrial methionyl-tRNA formyltransferase | ![]() |
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2 | 2 | ||||||
MIRT697306 | ZNF652 | zinc finger protein 652 | ![]() |
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2 | 2 | ||||||
MIRT698736 | STX12 | syntaxin 12 | ![]() |
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2 | 2 | ||||||
MIRT701055 | PARP2 | poly(ADP-ribose) polymerase 2 | ![]() |
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2 | 2 | ||||||
MIRT701197 | OTUD3 | OTU deubiquitinase 3 | ![]() |
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2 | 2 | ||||||
MIRT701334 | NSD1 | nuclear receptor binding SET domain protein 1 | ![]() |
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2 | 2 | ||||||
MIRT703617 | FBXO45 | F-box protein 45 | ![]() |
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2 | 2 | ||||||
MIRT708893 | ZNF780A | zinc finger protein 780A | ![]() |
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2 | 2 | ||||||
MIRT711621 | DGKH | diacylglycerol kinase eta | ![]() |
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2 | 2 | ||||||
MIRT713744 | TMEM81 | transmembrane protein 81 | ![]() |
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2 | 2 | ||||||
MIRT715060 | TMTC1 | transmembrane and tetratricopeptide repeat containing 1 | ![]() |
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2 | 2 | ||||||
MIRT719711 | CD101 | CD101 molecule | ![]() |
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2 | 2 | ||||||
MIRT720293 | DLGAP3 | DLG associated protein 3 | ![]() |
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2 | 2 | ||||||
MIRT722605 | CCDC152 | coiled-coil domain containing 152 | ![]() |
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2 | 2 | ||||||
MIRT724565 | ACSBG1 | acyl-CoA synthetase bubblegum family member 1 | ![]() |
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2 | 2 |
miRNA-Drug Associations | ||||||||||||||||||
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miRNA-Drug Resistance Associations | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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