miRTarBase - #MIRT694479


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pre-miRNA Information
pre-miRNA hsa-mir-4457   
Genomic Coordinates chr5: 1309310 - 1309377
Description Homo sapiens miR-4457 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4457
Sequence 43| UCACAAGGUAUUGACUGGCGUA |64
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1031676297 8 dbSNP
rs1249861366 14 dbSNP
rs115769169 17 dbSNP
rs968846507 19 dbSNP
rs540870271 20 dbSNP
rs993130937 22 dbSNP
Putative Targets

Gene Information
Gene Symbol LRTOMT   
Synonyms CFAP111, DFNB63, LRRC51
Description leucine rich transmembrane and O-methyltransferase domain containing
Transcript NM_001145308   
Other Transcripts NM_001145307 , NM_001145309 , NM_001145310 , NM_145309   
Expression
Putative miRNA Targets on LRTOMT
3'UTR of LRTOMT
(miRNA target sites are highlighted)		 
>LRTOMT|NM_001145308|3'UTR
   1 GGTCCAGGCCCAGGGGTACTTACTGATGCCCACCCCCACCCCCACCCAAGCAGGGACCTCAAAATCCCCTCCCTTTCCTG
  81 TTTGGGGCCTTGACACACGCTGGGCTCAGGGCTAGGGAGTCTCTCTTCCCACCTCTGACCTCTTTCAGCCTCTACACTGA
 161 CCTCAAGTGTCAAGTTCTATCAGGCTGCTTGGTCTCACTAGGCCCCCTCTTTCCAGAGAGAACCATGGACTGACAGCAAG
 241 AAGCCTGAGCTCCCGACCCAGCTCTGTCACTGATTTGCTGAGTGACTCCAAGGGAATCCCCACCTTGCTCTGAGATTTAA
 321 TCTTCTCTCTTAACACGAAGGAAGCTGGATGGGAGAGCTCCAGGGGCCTCCCAGTTCTCGGCCTCAGAAAGCCTCCCATC
 401 CTCAGCCCATGCCATTCTGGGTGGGATCAGAGGAAGTGGCAATGAGTTAGACGCCCTGCAGGAATAGCTGGATGCAAGCT
 481 GGGCCAGAGAAAATGGCACAGAACCCTGGACCCAGGGCCAGGGATGCCCTGGCCTTCCCTAACTCTGGCCCACCTAGCCA
 561 ATTAGGTGTGGCTGATGTCCCTTGAGTGCCCTCTTCCTAAAGCCCAAAAGAAGATGCTGGACTCCTCTGGGCCCCACCAA
 641 CAAATAGGGAATAGACATGGGTGGAAAATCACTCCTTTGTCTTTATTAAAGAAACTTAGACCAGACCTGGCAATCAAGGG
 721 GTGAGGTACTGGCCAGGAAGGTGGAGTAGGTTTCAGGCCCTGGGGATTTCAAGTGCAGACTGATGGCCTGGGAGGGGCCA
 801 AAGAGACCAGATCCTGGCAGCAGCTGAGGAGGTGCCCAAGGGCACTTTCAGGCACTGGGGCCATCAGCTGGTTCTGTGGG
 881 CAGGGGTTGGGGGTTGGGATGCAGGGTAGTTTGGGCTGGCCTGGAATCTCCCTGAGGCCACCCTGCCTTGTCTACCTAGA
 961 TCATCCACTGGTCCTGATCCTGTTCGTTGCCTTCCATGTCCACCTGGAGAGGAGGCTGGGTGTGGGTGGGGAGGGGCCTC
1041 AGCCAGCCTCAGCCCCAGATCCTGCCCCTGGCTGGATCCAGGGTTTCTGTACCCCTTGGCCATCAACTGGGTCAGGAGCA
1121 AGGGTCCAGGAACAGAGGCCCTCCCCCATACCCCTTGCCTACCTCATTGACCTCTCCATCATCCGGTGACTCATTGTAGT
1201 CATTCATCTCGTCCATGTCCTGCATATCCTCATCATCCTCTGAGTCCTCTTCACTATCCTCATCATCTTCATCATCCTCT
1281 TCTTCCTCGTCATCATAGTGCTGGTGGGCAGGACAGAGCCTGTAAGCCCTACAGGCCTGCATGGACCAGTTCAAGAACTG
1361 ACCCACTTGAGCCTCTCTCTAGGGCCAATGAATGACCCCCTACCCCGACACTCCCTCCTTGAGTCTAGCAGGCTGGTGCA
1441 TGTTCTGCAGGACCTTAATGCTAGGCCCAATGCCCACCCCTTCTATCTCCCCTTTTAGGCTTTTACCCAGATCTGAGAAC
1521 CACAACTGCTCTGGGTCAGAGACAGGACATTCAGAATTAGAGCAGAGCCTCGGTCCACTGCGGCCCCCACACAGGCCCCA
1601 CCTGCTAGAGCCACTCACCTCTGAGGCTGGCTTGCCAATAGGAACCAGGTTGTTGTCTTTCTCCGCGATGCTTTGGAGCT
1681 GTGGGCAAAGGCACAGAGGAACAAGGCCAGAGCCCAAGTAGGGCAGGTCAGGGGCATGGGACTGGCCCATTCTGCCCAGA
1761 AGACAACCCACACGTGTTGGGGAGAAGCTTCCTCCCAGTTCTCAGGGAGATACAATCCCTTTCTTGTCATCTGCCATTTA
1841 TGAACTTGATCCAAATAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' augCGGUCAGUUAUGGAACAcu 5'
             ||||  |  |:||||||  
Target 5' gagGCCA--CCCTGCCTTGTct 3'
 934 - 953 135.00 -12.90
2 
miRNA  3' auGCGGUCAGUUAUGGAACACu 5'
            || || ||  | ||||| | 
Target 5' ccCGACACTCCCT-CCTTGAGt 3'
 1404 - 1424 123.00 -8.40
3 
miRNA  3' augcgGUCAGUUAUGGAACAcu 5'
               || ||  | :|||||  
Target 5' agataCAATCCCTTTCTTGTca 3'
 1808 - 1829 117.00 -5.30
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
881378 206 ClinVar
881379 245 ClinVar
306004 256 ClinVar
306005 262 ClinVar
306006 337 ClinVar
306007 380 ClinVar
881824 401 ClinVar
306008 438 ClinVar
882974 581 ClinVar
306009 602 ClinVar
306010 623 ClinVar
882975 639 ClinVar
882976 852 ClinVar
882977 861 ClinVar
306011 878 ClinVar
306012 1117 ClinVar
306013 1161 ClinVar
306014 1186 ClinVar
883772 1226 ClinVar
306015 1266 ClinVar
306016 1364 ClinVar
306017 1396 ClinVar
881433 1489 ClinVar
881434 1545 ClinVar
306018 1582 ClinVar
881435 1609 ClinVar
306019 1774 ClinVar
306020 1789 ClinVar
306021 1811 ClinVar
COSN30527214 34 COSMIC
COSN28725727 108 COSMIC
COSN1137445 238 COSMIC
COSN28559648 380 COSMIC
COSN30739070 401 COSMIC
COSN31516320 625 COSMIC
COSN31590163 722 COSMIC
COSN23554733 772 COSMIC
COSN32053550 866 COSMIC
COSN30502151 880 COSMIC
COSN30509141 890 COSMIC
COSN31495137 891 COSMIC
COSN20071050 922 COSMIC
COSN30184797 924 COSMIC
COSN30502855 944 COSMIC
COSM931653 986 COSMIC
COSM4036436 991 COSMIC
COSM8596701 1013 COSMIC
COSN26983187 1023 COSMIC
COSN28880383 1052 COSMIC
COSN31509301 1062 COSMIC
COSN30459403 1082 COSMIC
COSN30109485 1084 COSMIC
COSN30482437 1096 COSMIC
COSN30548474 1101 COSMIC
COSN28851115 1123 COSMIC
COSN30193560 1136 COSMIC
COSN30501587 1146 COSMIC
COSM4423969 1186 COSMIC
COSM7175670 1206 COSMIC
COSM6040920 1214 COSMIC
COSM4036437 1224 COSMIC
COSM8783705 1241 COSMIC
COSM7628014 1256 COSMIC
COSM4146287 1266 COSMIC
COSM9143499 1277 COSMIC
COSM4036438 1278 COSMIC
COSM6599528 1283 COSMIC
COSM7293117 1297 COSMIC
COSM6272797 1301 COSMIC
COSN28174277 1324 COSMIC
COSN31494159 1370 COSMIC
COSN32053622 1370 COSMIC
COSN21681131 1374 COSMIC
COSN30485548 1378 COSMIC
COSN30164024 1381 COSMIC
COSN31488777 1395 COSMIC
COSN30617340 1400 COSMIC
COSN32059473 1422 COSMIC
COSN30187516 1423 COSMIC
COSN31508693 1436 COSMIC
COSN30526039 1511 COSMIC
COSN30522946 1518 COSMIC
COSN30526031 1518 COSMIC
COSN30454474 1535 COSMIC
COSN30193599 1542 COSMIC
COSN30164155 1557 COSMIC
COSN30105295 1561 COSMIC
COSN26983185 1564 COSMIC
COSN31501419 1566 COSMIC
COSN30133288 1578 COSMIC
COSN31876370 1584 COSMIC
COSN28884859 1594 COSMIC
COSN31498452 1606 COSMIC
COSM7846865 1617 COSMIC
COSM7862446 1617 COSMIC
COSM4953239 1619 COSMIC
COSM8688529 1636 COSMIC
COSM6599529 1641 COSMIC
COSM7465199 1641 COSMIC
COSM5373538 1643 COSMIC
COSM3967817 1651 COSMIC
COSM6317067 1656 COSMIC
COSM8915169 1662 COSMIC
COSM2016031 1665 COSMIC
COSM6871147 1666 COSMIC
COSM8607719 1667 COSMIC
COSM4823006 1668 COSMIC
COSN30500218 1718 COSMIC
COSN30183230 1759 COSMIC
COSN31581007 1802 COSMIC
COSN30143355 1810 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1275546069 2 dbSNP
rs1373334730 4 dbSNP
rs773983684 6 dbSNP
rs1279592770 8 dbSNP
rs1026023983 9 dbSNP
rs1342601420 20 dbSNP
rs759862161 29 dbSNP
rs1343050513 30 dbSNP
rs1380090558 33 dbSNP
rs71469421 33 dbSNP
rs1207040589 34 dbSNP
rs762334109 36 dbSNP
rs950354642 37 dbSNP
rs1436897779 38 dbSNP
rs1165575155 39 dbSNP
rs1199181901 40 dbSNP
rs984422120 41 dbSNP
rs1404890918 45 dbSNP
rs1323996733 48 dbSNP
rs1379158342 49 dbSNP
rs1413706562 53 dbSNP
rs1399561737 71 dbSNP
rs1173992254 75 dbSNP
rs1470044635 77 dbSNP
rs1173759056 79 dbSNP
rs1016024999 81 dbSNP
rs1479083021 83 dbSNP
rs548947474 86 dbSNP
rs948059983 89 dbSNP
rs1187228655 99 dbSNP
rs1441067128 100 dbSNP
rs376514789 103 dbSNP
rs1376715255 104 dbSNP
rs1258760351 107 dbSNP
rs1204512529 111 dbSNP
rs1412601227 114 dbSNP
rs1256219713 116 dbSNP
rs567452783 120 dbSNP
rs534644428 124 dbSNP
rs928062227 136 dbSNP
rs553247286 147 dbSNP
rs1335925790 152 dbSNP
rs571179861 157 dbSNP
rs933277974 166 dbSNP
rs1335984193 168 dbSNP
rs1452914803 176 dbSNP
rs1047263308 188 dbSNP
rs988688218 199 dbSNP
rs887239749 200 dbSNP
rs1372575768 203 dbSNP
rs1163160263 207 dbSNP
rs1234907011 219 dbSNP
rs538247137 245 dbSNP
rs1005820299 247 dbSNP
rs1281202146 250 dbSNP
rs1457436162 255 dbSNP
rs191758747 256 dbSNP
rs561766061 262 dbSNP
rs886048637 262 dbSNP
rs1278202812 263 dbSNP
rs1438489632 264 dbSNP
rs1289306023 268 dbSNP
rs1227647070 273 dbSNP
rs1354249412 276 dbSNP
rs1316878839 279 dbSNP
rs1246461277 284 dbSNP
rs1043682394 299 dbSNP
rs903958126 300 dbSNP
rs898851423 311 dbSNP
rs938079321 315 dbSNP
rs886048638 337 dbSNP
rs1354577179 351 dbSNP
rs1322379220 352 dbSNP
rs1404080848 353 dbSNP
rs1247925325 366 dbSNP
rs1452093655 367 dbSNP
rs1192308399 370 dbSNP
rs995845513 372 dbSNP
rs1378648345 374 dbSNP
rs1029194701 375 dbSNP
rs575033917 379 dbSNP
rs73543612 380 dbSNP
rs555713032 381 dbSNP
rs1324507235 396 dbSNP
rs1030803490 397 dbSNP
rs1438886255 399 dbSNP
rs956514341 401 dbSNP
rs1365856067 402 dbSNP
rs1222885037 405 dbSNP
rs1229289418 410 dbSNP
rs574163705 413 dbSNP
rs1306852780 416 dbSNP
rs886652224 417 dbSNP
rs1210049892 422 dbSNP
rs1005909665 424 dbSNP
rs1273671147 428 dbSNP
rs1212943466 429 dbSNP
rs1433679306 434 dbSNP
rs766985557 438 dbSNP
rs1458670987 444 dbSNP
rs1212541397 445 dbSNP
rs542916754 449 dbSNP
rs1358989690 451 dbSNP
rs749999049 453 dbSNP
rs980793570 454 dbSNP
rs1424742950 455 dbSNP
rs1371675893 460 dbSNP
rs1189484749 463 dbSNP
rs1479059794 466 dbSNP
rs1269751651 469 dbSNP
rs927914671 470 dbSNP
rs974883616 471 dbSNP
rs1030197679 480 dbSNP
rs564855453 488 dbSNP
rs752255559 494 dbSNP
rs939460225 505 dbSNP
rs140497216 509 dbSNP
rs1216925256 513 dbSNP
rs1346824019 528 dbSNP
rs908730197 531 dbSNP
rs150413720 539 dbSNP
rs1290943997 554 dbSNP
rs746232264 560 dbSNP
rs1431942801 562 dbSNP
rs1358748821 570 dbSNP
rs1174188214 573 dbSNP
rs1416416166 581 dbSNP
rs1038664843 592 dbSNP
rs116397624 602 dbSNP
rs545429308 604 dbSNP
rs1188003747 608 dbSNP
rs772385705 615 dbSNP
rs1486085886 616 dbSNP
rs563664200 618 dbSNP
rs1236734132 619 dbSNP
rs1207548348 621 dbSNP
rs776032348 623 dbSNP
rs1050100190 627 dbSNP
rs530955235 629 dbSNP
rs1263207880 633 dbSNP
rs890086074 636 dbSNP
rs1217502070 639 dbSNP
rs879214664 646 dbSNP
rs1340369232 647 dbSNP
rs1197750610 648 dbSNP
rs765695814 649 dbSNP
rs1008617007 652 dbSNP
rs1301522000 653 dbSNP
rs1454766334 656 dbSNP
rs1407129534 657 dbSNP
rs1330682105 658 dbSNP
rs1464161017 659 dbSNP
rs1371221712 675 dbSNP
rs370839713 679 dbSNP
rs1255471129 692 dbSNP
rs1429091916 705 dbSNP
rs1412796545 706 dbSNP
rs1179963863 713 dbSNP
rs1462335256 717 dbSNP
rs1453077537 720 dbSNP
rs1197417253 736 dbSNP
rs1456050361 738 dbSNP
rs1197598839 755 dbSNP
rs1228781913 760 dbSNP
rs1030688897 764 dbSNP
rs761133046 767 dbSNP
rs1047896671 771 dbSNP
rs1476223478 773 dbSNP
rs1308829016 774 dbSNP
rs886709395 776 dbSNP
rs1398690752 778 dbSNP
rs1165787839 783 dbSNP
rs1006458849 792 dbSNP
rs1462422879 797 dbSNP
rs1349243654 801 dbSNP
rs1161370870 805 dbSNP
rs1037399084 806 dbSNP
rs900158154 819 dbSNP
rs1010685773 821 dbSNP
rs1177586946 825 dbSNP
rs995977850 831 dbSNP
rs1030495165 833 dbSNP
rs1010045590 834 dbSNP
rs182422646 835 dbSNP
rs1020058059 836 dbSNP
rs1488402132 837 dbSNP
rs1171172445 840 dbSNP
rs1264233713 850 dbSNP
rs186960319 852 dbSNP
rs528310434 859 dbSNP
rs969334895 862 dbSNP
rs750733779 869 dbSNP
rs113912971 878 dbSNP
rs571214744 881 dbSNP
rs1337817086 883 dbSNP
rs1307725240 887 dbSNP
rs925347105 888 dbSNP
rs867976634 891 dbSNP
rs1366774283 895 dbSNP
rs1475323905 907 dbSNP
rs756085002 909 dbSNP
rs1396964256 910 dbSNP
rs375515751 912 dbSNP
rs990802521 913 dbSNP
rs1157882752 914 dbSNP
rs1237180245 915 dbSNP
rs368065020 917 dbSNP
rs754743997 920 dbSNP
rs1383827438 923 dbSNP
rs1365187184 925 dbSNP
rs376501947 927 dbSNP
rs1325637987 930 dbSNP
rs201466115 932 dbSNP
rs747252610 934 dbSNP
rs949424798 937 dbSNP
rs1332258006 938 dbSNP
rs568489908 942 dbSNP
rs1268168663 944 dbSNP
rs1266209880 946 dbSNP
rs781229636 946 dbSNP
rs535999979 947 dbSNP
rs1202189144 948 dbSNP
rs1190025027 949 dbSNP
rs769897536 954 dbSNP
rs1446715498 955 dbSNP
rs1189110159 956 dbSNP
rs554667086 960 dbSNP
rs1472776388 968 dbSNP
rs1474331559 975 dbSNP
rs749760055 979 dbSNP
rs1412783056 984 dbSNP
rs982888986 986 dbSNP
rs1402569929 987 dbSNP
rs200715567 992 dbSNP
rs769057498 998 dbSNP
rs774633993 1000 dbSNP
rs1396349490 1002 dbSNP
rs761502371 1008 dbSNP
rs367771928 1009 dbSNP
rs1285345951 1010 dbSNP
rs941545183 1015 dbSNP
rs1413760431 1016 dbSNP
rs773029429 1017 dbSNP
rs1406679455 1030 dbSNP
rs1318189773 1035 dbSNP
rs371950563 1036 dbSNP
rs1038354872 1038 dbSNP
rs775871136 1046 dbSNP
rs1211993101 1051 dbSNP
rs766000783 1058 dbSNP
rs1190324599 1070 dbSNP
rs900712356 1075 dbSNP
rs1465268414 1088 dbSNP
rs1484928645 1097 dbSNP
rs35878870 1100 dbSNP
rs1187494417 1102 dbSNP
rs753742929 1104 dbSNP
rs759459431 1107 dbSNP
rs1157044457 1108 dbSNP
rs1363123861 1111 dbSNP
rs1466462550 1116 dbSNP
rs375298971 1117 dbSNP
rs752485472 1118 dbSNP
rs757472656 1120 dbSNP
rs1308189546 1123 dbSNP
rs1335966811 1124 dbSNP
rs781355244 1136 dbSNP
rs996250328 1138 dbSNP
rs761318385 1143 dbSNP
rs1340774537 1144 dbSNP
rs750669710 1147 dbSNP
rs369633633 1148 dbSNP
rs1051415901 1151 dbSNP
rs749785252 1152 dbSNP
rs769088945 1156 dbSNP
rs201099496 1161 dbSNP
rs1210636740 1168 dbSNP
rs553564991 1172 dbSNP
rs1481762194 1177 dbSNP
rs776650675 1181 dbSNP
rs1175744985 1184 dbSNP
rs145107371 1185 dbSNP
rs531848254 1186 dbSNP
rs1327946895 1189 dbSNP
rs1195418451 1194 dbSNP
rs1393195555 1195 dbSNP
rs1453510077 1203 dbSNP
rs890149357 1209 dbSNP
rs578260292 1212 dbSNP
rs1403460092 1213 dbSNP
rs770561386 1218 dbSNP
rs1423476716 1226 dbSNP
rs1469899576 1226 dbSNP
rs776063572 1239 dbSNP
rs765381065 1240 dbSNP
rs958620482 1242 dbSNP
rs765130044 1248 dbSNP
rs147594350 1255 dbSNP
rs563702951 1256 dbSNP
rs1479468023 1260 dbSNP
rs1373978370 1263 dbSNP
rs17161980 1266 dbSNP
rs750635497 1269 dbSNP
rs1245232164 1275 dbSNP
rs1296704860 1276 dbSNP
rs756382677 1278 dbSNP
rs1202674899 1281 dbSNP
rs780157398 1290 dbSNP
rs753901875 1291 dbSNP
rs983526461 1292 dbSNP
rs199779840 1293 dbSNP
rs779238115 1297 dbSNP
rs748701382 1308 dbSNP
rs1187077471 1312 dbSNP
rs1421375329 1317 dbSNP
rs1426588480 1319 dbSNP
rs772497729 1320 dbSNP
rs1418142273 1322 dbSNP
rs904996040 1323 dbSNP
rs1462517300 1325 dbSNP
rs778349482 1329 dbSNP
rs561436693 1330 dbSNP
rs770757770 1333 dbSNP
rs1290024027 1334 dbSNP
rs776177568 1335 dbSNP
rs192963404 1337 dbSNP
rs769372273 1339 dbSNP
rs1426408910 1343 dbSNP
rs1335752456 1345 dbSNP
rs546427194 1349 dbSNP
rs1271317065 1352 dbSNP
rs764832702 1356 dbSNP
rs1371363360 1359 dbSNP
rs1468130118 1360 dbSNP
rs759367241 1364 dbSNP
rs763858916 1368 dbSNP
rs185280082 1369 dbSNP
rs1398886945 1370 dbSNP
rs1397838131 1396 dbSNP
rs532299898 1396 dbSNP
rs561551303 1396 dbSNP
rs886048639 1396 dbSNP
rs1162993127 1397 dbSNP
rs894914936 1403 dbSNP
rs960727867 1405 dbSNP
rs982774430 1407 dbSNP
rs1255220199 1408 dbSNP
rs1439389499 1416 dbSNP
rs1015728484 1421 dbSNP
rs945839322 1422 dbSNP
rs1184094504 1425 dbSNP
rs962791943 1426 dbSNP
rs904248125 1441 dbSNP
rs1365499732 1448 dbSNP
rs1221401085 1450 dbSNP
rs1356982580 1463 dbSNP
rs974532751 1472 dbSNP
rs550446274 1485 dbSNP
rs568780022 1486 dbSNP
rs932792064 1489 dbSNP
rs1443779920 1494 dbSNP
rs987098150 1499 dbSNP
rs536269368 1517 dbSNP
rs1435647188 1518 dbSNP
rs894406121 1520 dbSNP
rs1164678506 1526 dbSNP
rs1014158498 1532 dbSNP
rs912805774 1545 dbSNP
rs1160334967 1546 dbSNP
rs370124771 1556 dbSNP
rs1470568154 1566 dbSNP
rs1246254183 1569 dbSNP
rs201339132 1570 dbSNP
rs369798854 1572 dbSNP
rs766470230 1573 dbSNP
rs1222953283 1574 dbSNP
rs754110853 1577 dbSNP
rs373529881 1582 dbSNP
rs375635711 1583 dbSNP
rs750009295 1584 dbSNP
rs1413936587 1585 dbSNP
rs759032367 1587 dbSNP
rs1225165355 1589 dbSNP
rs758099655 1590 dbSNP
rs778261727 1593 dbSNP
rs747419504 1597 dbSNP
rs757673616 1602 dbSNP
rs200898905 1603 dbSNP
rs913535244 1605 dbSNP
rs946481782 1606 dbSNP
rs745551454 1608 dbSNP
rs769123440 1609 dbSNP
rs1286203386 1611 dbSNP
rs1304061720 1617 dbSNP
rs905048896 1618 dbSNP
rs1315092579 1619 dbSNP
rs1400484644 1624 dbSNP
rs17849989 1626 dbSNP
rs1343607138 1633 dbSNP
rs749197566 1634 dbSNP
rs1486565526 1639 dbSNP
rs768617478 1640 dbSNP
rs963425454 1643 dbSNP
rs1256371622 1649 dbSNP
rs138271743 1665 dbSNP
rs202222531 1666 dbSNP
rs767356574 1667 dbSNP
rs539199138 1668 dbSNP
rs759869247 1670 dbSNP
rs557706099 1673 dbSNP
rs1256215780 1679 dbSNP
rs752875020 1682 dbSNP
rs753915114 1683 dbSNP
rs370192741 1686 dbSNP
rs1340121907 1689 dbSNP
rs1442972424 1690 dbSNP
rs764658753 1700 dbSNP
rs1485407789 1705 dbSNP
rs896403111 1706 dbSNP
rs199958250 1711 dbSNP
rs766174504 1713 dbSNP
rs922112331 1713 dbSNP
rs757509145 1717 dbSNP
rs781626202 1720 dbSNP
rs543014197 1721 dbSNP
rs1447277669 1734 dbSNP
rs1015612595 1735 dbSNP
rs1261903932 1737 dbSNP
rs962676481 1740 dbSNP
rs932261223 1743 dbSNP
rs554657170 1748 dbSNP
rs1326227286 1755 dbSNP
rs995625058 1756 dbSNP
rs1214553281 1760 dbSNP
rs1360279522 1763 dbSNP
rs767267287 1773 dbSNP
rs561162900 1774 dbSNP
rs573332460 1775 dbSNP
rs1395541795 1778 dbSNP
rs1406982938 1779 dbSNP
rs912690379 1780 dbSNP
rs886048640 1789 dbSNP
rs1427917053 1793 dbSNP
rs1454775106 1796 dbSNP
rs1417111358 1804 dbSNP
rs752561720 1806 dbSNP
rs142914900 1811 dbSNP
rs1242180799 1823 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions Hela
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1048187. RNA binding protein: AGO2. Condition:Hela_AGO2_CLIP_control ...

- Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al., 2013, Cell.

Article - Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al.
- Cell, 2013
The induction of pluripotency or trans-differentiation of one cell type to another can be accomplished with cell-lineage-specific transcription factors. Here, we report that repression of a single RNA binding polypyrimidine-tract-binding (PTB) protein, which occurs during normal brain development via the action of miR-124, is sufficient to induce trans-differentiation of fibroblasts into functional neurons. Besides its traditional role in regulated splicing, we show that PTB has a previously undocumented function in the regulation of microRNA functions, suppressing or enhancing microRNA targeting by competitive binding on target mRNA or altering local RNA secondary structure. A key event during neuronal induction is the relief of PTB-mediated blockage of microRNA action on multiple components of the REST complex, thereby derepressing a large array of neuronal genes, including miR-124 and multiple neuronal-specific transcription factors, in nonneuronal cells. This converts a negative feedback loop to a positive one to elicit cellular reprogramming to the neuronal lineage.
LinkOut: [PMID: 23313552]
CLIP-seq Support 1 for dataset GSM1048187
Method / RBP HITS-CLIP / AGO2
Cell line / Condition Hela / Hela_AGO2_CLIP_control
Location of target site ENST00000324866.7 | 3UTR | UUGUAUUUUUAGUAGAGACGGGGUUUCACCAUGUUAGCCAGGAUGGUCUCCAUCUCCUGACCUUGUGAUCCACCC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23313552 / GSE42701
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
83 hsa-miR-4457 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT098032 SOBP sine oculis binding protein homolog 2 2
MIRT202580 PCMTD2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2 2 6
MIRT247137 WEE1 WEE1 G2 checkpoint kinase 2 4
MIRT349266 PTBP1 polypyrimidine tract binding protein 1 2 2
MIRT363756 EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 2 2
MIRT443586 FAM84B family with sequence similarity 84 member B 2 2
MIRT452333 EIF5AL1 eukaryotic translation initiation factor 5A-like 1 2 2
MIRT453864 ZBTB40 zinc finger and BTB domain containing 40 2 4
MIRT471486 PDE4D phosphodiesterase 4D 2 4
MIRT476290 GMFB glia maturation factor beta 2 8
MIRT479897 CCDC117 coiled-coil domain containing 117 2 4
MIRT484251 ANK1 ankyrin 1 2 2
MIRT491473 TMEM214 transmembrane protein 214 2 2
MIRT493804 GAN gigaxonin 2 6
MIRT499252 VAV3 vav guanine nucleotide exchange factor 3 2 4
MIRT502271 HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 2 4
MIRT504651 RPL9 ribosomal protein L9 2 6
MIRT505211 UBN2 ubinuclein 2 2 8
MIRT508952 SNRPB small nuclear ribonucleoprotein polypeptides B and B1 2 4
MIRT512691 POP1 POP1 homolog, ribonuclease P/MRP subunit 2 2
MIRT513320 SCUBE3 signal peptide, CUB domain and EGF like domain containing 3 2 2
MIRT513870 HOXA5 homeobox A5 2 2
MIRT517342 ZNF529 zinc finger protein 529 2 4
MIRT518947 LSG1 large 60S subunit nuclear export GTPase 1 2 2
MIRT520867 SUGT1 SGT1 homolog, MIS12 kinetochore complex assembly cochaperone 2 2
MIRT528325 GIGYF2 GRB10 interacting GYF protein 2 2 2
MIRT531990 SLCO1B3 solute carrier organic anion transporter family member 1B3 2 2
MIRT533298 USP46 ubiquitin specific peptidase 46 2 2
MIRT545257 TRIM36 tripartite motif containing 36 2 4
MIRT547038 POGZ pogo transposable element derived with ZNF domain 2 2
MIRT556103 MOAP1 modulator of apoptosis 1 2 2
MIRT558321 DR1 down-regulator of transcription 1 2 2
MIRT558521 CSRNP3 cysteine and serine rich nuclear protein 3 2 2
MIRT560906 TMED10 transmembrane p24 trafficking protein 10 2 2
MIRT568448 ARPP19 cAMP regulated phosphoprotein 19 2 2
MIRT570586 OTUD7B OTU deubiquitinase 7B 2 2
MIRT572799 SIGLEC14 sialic acid binding Ig like lectin 14 2 2
MIRT573863 C9orf78 chromosome 9 open reading frame 78 2 2
MIRT575058 P2ry1 purinergic receptor P2Y, G-protein coupled 1 2 5
MIRT609931 SLC38A1 solute carrier family 38 member 1 2 4
MIRT610836 ZNF585A zinc finger protein 585A 2 4
MIRT611474 P2RY1 purinergic receptor P2Y1 2 7
MIRT613569 YY2 YY2 transcription factor 2 2
MIRT618626 GREB1 growth regulation by estrogen in breast cancer 1 2 2
MIRT620606 SAP30 Sin3A associated protein 30 2 2
MIRT621017 CLSTN3 calsyntenin 3 2 4
MIRT635314 FAM179A TOG array regulator of axonemal microtubules 2 2 2
MIRT635919 GLTSCR2 NOP53 ribosome biogenesis factor 2 2
MIRT640598 TM9SF4 transmembrane 9 superfamily member 4 2 2
MIRT641784 YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta 2 4
MIRT644067 IQCE IQ motif containing E 2 2
MIRT648288 TRAPPC2L trafficking protein particle complex 2 like 2 2
MIRT658085 FOXR2 forkhead box R2 2 2
MIRT659077 DEPTOR DEP domain containing MTOR interacting protein 2 2
MIRT665307 ZBTB37 zinc finger and BTB domain containing 37 2 2
MIRT665975 SYTL4 synaptotagmin like 4 2 2
MIRT666302 SLC25A25 solute carrier family 25 member 25 2 2
MIRT674906 RASSF9 Ras association domain family member 9 2 2
MIRT680086 THAP1 THAP domain containing 1 2 2
MIRT681488 DIP2A disco interacting protein 2 homolog A 2 2
MIRT691244 DFNB59 pejvakin 2 2
MIRT692362 AGTRAP angiotensin II receptor associated protein 2 2
MIRT693035 MB21D1 Mab-21 domain containing 1 2 2
MIRT693837 STAT5A signal transducer and activator of transcription 5A 2 2
MIRT694479 LRTOMT leucine rich transmembrane and O-methyltransferase domain containing 2 2
MIRT696070 ZNF264 zinc finger protein 264 2 2
MIRT696578 TTC21B tetratricopeptide repeat domain 21B 2 2
MIRT696760 MTFMT mitochondrial methionyl-tRNA formyltransferase 2 2
MIRT697307 ZNF652 zinc finger protein 652 2 2
MIRT700152 RNF115 ring finger protein 115 2 2
MIRT701056 PARP2 poly(ADP-ribose) polymerase 2 2 2
MIRT701198 OTUD3 OTU deubiquitinase 3 2 2
MIRT701335 NSD1 nuclear receptor binding SET domain protein 1 2 2
MIRT702656 ITGA3 integrin subunit alpha 3 2 2
MIRT703618 FBXO45 F-box protein 45 2 2
MIRT704673 CHTOP chromatin target of PRMT1 2 2
MIRT708894 ZNF780A zinc finger protein 780A 2 2
MIRT711620 DGKH diacylglycerol kinase eta 2 2
MIRT713745 TMEM81 transmembrane protein 81 2 2
MIRT719712 CD101 CD101 molecule 2 2
MIRT720294 DLGAP3 DLG associated protein 3 2 2
MIRT722606 CCDC152 coiled-coil domain containing 152 2 2
MIRT724566 ACSBG1 acyl-CoA synthetase bubblegum family member 1 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-4457 Dabrafenib 44462760 NSC764134 approved sensitive cell line (A375)
hsa-miR-4457 Gefitinib 123631 NSC715055 approved sensitive cell line (PC9)
hsa-miR-4457 Osimertinib 71496458 NSC779217 approved sensitive cell line (PC9)
hsa-miR-4457 Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)

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