pre-miRNA Information
pre-miRNA hsa-mir-125b-2   
Genomic Coordinates chr21: 16590237 - 16590325
Synonyms MIRN125B2, MIR125B2
Description Homo sapiens miR-125b-2 stem-loop
Comment This miRNA sequence is predicted based on homology to a verified miRNA from mouse .
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-125b-2-3p
Sequence 54| UCACAAGUCAGGCUCUUGGGAC |75
Evidence Experimental
Experiments Cloned
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 3 21 + 16590292 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs575583557 6 dbSNP
rs1331783293 22 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol TTC21B   
Synonyms ATD4, IFT139, IFT139B, JBTS11, NPHP12, Nbla10696, SRTD4, THM1
Description tetratricopeptide repeat domain 21B
Transcript NM_024753   
Expression
Putative miRNA Targets on TTC21B
3'UTR of TTC21B
(miRNA target sites are highlighted)
>TTC21B|NM_024753|3'UTR
   1 AAATAATTTTAACTTAGGTGTTGGTTTAACAGGAAATGAAAGAAATCTAACTTTCAGTTCTTCCTGTTCAAAACAGGTTT
  81 GAGCTCAGTGCTTTGTTATTAGAAGTATACCCTTTTTTCTCCAGCAGAGGTTGCTGCTGTACATCAAGAGAAGTACTATG
 161 TGAAATTGGTGTTTCCTAATGGAGTTGAATGAGAGCTGGTCTATTTGACTCTGTTTTGATTGGGTACAGATTTGGTGACT
 241 CTGTGGTAAAGACTATAATTATTTCTATAAAGAATATTTTGTTAAAATCTAGGTAATTAAATACCCTGTATCTTTTCTAA
 321 GGAATATTATTTCAGGAAATATATTTAAAATGCATTGTTCTCTTTTAAAGTGTTTTTGTTATATTCTTTTATTTATTTAT
 401 TTATTTTTAAAGACAGAGCCTTGATCTGCCGCCCAGGCTGGAGTGCAGTGGCACGATCTTGGCTCACTGCAACCTCCGCC
 481 TCCTGGGTTTACGCGATTCTCCTGCTTCAGCCTCCCGAGTAGCTGGGACTAAAGGCATGTGCCATCACACCCGGCTAATT
 561 TTTTGTATTTTTAGTAGAGATGGGATTTCACCGTGTTAGCCAGGAGGGGCTTGATCTCTTGACCTTGTGATCCACCTGCC
 641 TCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCGCACCCAGCCTGTTTTTGTTGTATTCTGTGTTGTTTCAAA
 721 AATTGGAATAAATCTCCCTGTAAATAACTCATGAAAAAGACAATATATATATTTTAAATATATATTTTAATAAAGGTTTT
 801 ATAAATAGATGATTTATATTCCTCTTGGAACTCAAAAGATGTGGTAAGTTTTGCAAATCAGGGTAAGCTCCCCCTGCATT
 881 CTGTAATGTTAATGGGTGGTGGTATAGTACAGAAAATGTAACTTTCATTGAAAAATCTTTTTTAGAAAAGGGTAGAGTGT
 961 GTGTTTCCCTTTCCTTTCTTGAGCTCATTCTTCCTGCTTTCAAGGCCATTGTGGTCTTAAGAAATAATCAGGTCCTGAAA
1041 CCTCAATTTAAATAGGTCCCTTATTAGGGATATTTAACCTTAGCCTAGAAGACTTGGTCTGCAGGTATAATTTCAGACAC
1121 TGTAACATTTGATGGTAAAGGGTGACCAAATACTTTTGGTCAGCAGGGAGTCACAAAGCACACCATGTGAAGGCAACGGT
1201 TTACCCAGCTCTGTTTAACAGCACCCTGGCATAGAAGCTTTCACTCTCTTACACTAAATTTAACCTAATCTAAACTTAAT
1281 CCTTAGCATTATTTTTAATTTCTCATCTACATCTTTTTCAATTTTCCTTAAAATTGTAGTAAACACAGTCCTCAATTTTA
1361 TTTGCATTTACAATAAACAGTATTTATAAGTCAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' caGGGUUCUCGGACU-GAACACu 5'
            |:::|   |:||| |||||| 
Target 5' ggCTTGATCTCTTGACCTTGTGa 3'
608 - 630 128.00 -15.00
2
miRNA  3' cagGGUUCUCGGACUGA-ACACu 5'
             :||||||    ||| |||| 
Target 5' acaTCAAGAGAAGTACTATGTGa 3'
141 - 163 127.00 -15.80
3
miRNA  3' caggguUCUCGG--ACUGA-ACACu 5'
                ||| ::  ||||| |||| 
Target 5' gggtacAGATTTGGTGACTCTGTGg 3'
222 - 246 122.00 -10.10
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
331818 105 ClinVar
331817 246 ClinVar
894540 360 ClinVar
331816 419 ClinVar
894136 424 ClinVar
331815 451 ClinVar
331814 460 ClinVar
331813 473 ClinVar
331812 516 ClinVar
331811 517 ClinVar
331810 531 ClinVar
331809 540 ClinVar
331808 544 ClinVar
331807 593 ClinVar
331806 642 ClinVar
331805 656 ClinVar
331804 680 ClinVar
894502 681 ClinVar
331803 730 ClinVar
331802 847 ClinVar
331801 878 ClinVar
331800 910 ClinVar
894108 926 ClinVar
893253 974 ClinVar
331799 1087 ClinVar
893252 1104 ClinVar
331798 1105 ClinVar
893039 1107 ClinVar
893038 1117 ClinVar
331797 1124 ClinVar
893037 1225 ClinVar
COSN31610998 16 COSMIC
COSN31509542 24 COSMIC
COSN26553875 51 COSMIC
COSN30168758 69 COSMIC
COSN28754451 75 COSMIC
COSN30128565 106 COSMIC
COSN31538637 112 COSMIC
COSN31491492 114 COSMIC
COSN31564394 117 COSMIC
COSN13946785 131 COSMIC
COSN31546532 279 COSMIC
COSN30512572 342 COSMIC
COSN25657885 426 COSMIC
COSN16633247 822 COSMIC
COSN1228049 876 COSMIC
COSN7114685 894 COSMIC
COSN27036158 895 COSMIC
COSN9114303 1104 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1210710585 1 dbSNP
rs766935264 11 dbSNP
rs1408040873 18 dbSNP
rs763189834 21 dbSNP
rs773662917 23 dbSNP
rs1350223924 25 dbSNP
rs764592144 29 dbSNP
rs769882703 30 dbSNP
rs748456308 31 dbSNP
rs776683431 38 dbSNP
rs768656308 39 dbSNP
rs747104869 40 dbSNP
rs778771414 41 dbSNP
rs373155327 44 dbSNP
rs1439066444 53 dbSNP
rs1326992764 63 dbSNP
rs561372737 66 dbSNP
rs1439314401 74 dbSNP
rs1312038285 77 dbSNP
rs547743051 79 dbSNP
rs1018027581 83 dbSNP
rs1345812835 92 dbSNP
rs1171872567 95 dbSNP
rs1282441160 98 dbSNP
rs1323719462 101 dbSNP
rs1006934418 102 dbSNP
rs74548052 105 dbSNP
rs1034750302 107 dbSNP
rs1026835863 108 dbSNP
rs1233345991 109 dbSNP
rs748606861 111 dbSNP
rs1237610357 130 dbSNP
rs866767992 131 dbSNP
rs577122541 133 dbSNP
rs1002899157 144 dbSNP
rs1469185817 146 dbSNP
rs557228057 155 dbSNP
rs1047150809 158 dbSNP
rs545408261 169 dbSNP
rs1166165817 174 dbSNP
rs1317123802 177 dbSNP
rs1394234790 178 dbSNP
rs1460168050 179 dbSNP
rs1013670574 196 dbSNP
rs1270585200 203 dbSNP
rs1441644200 213 dbSNP
rs576217736 219 dbSNP
rs768035059 220 dbSNP
rs897660769 222 dbSNP
rs1037532837 226 dbSNP
rs1055226668 237 dbSNP
rs941940910 239 dbSNP
rs759810831 246 dbSNP
rs1332455064 255 dbSNP
rs562699518 257 dbSNP
rs191356850 261 dbSNP
rs573372477 290 dbSNP
rs1042649758 293 dbSNP
rs1238680159 302 dbSNP
rs945643814 308 dbSNP
rs1186820210 311 dbSNP
rs933012723 324 dbSNP
rs1379432132 343 dbSNP
rs1257932001 348 dbSNP
rs1332235268 354 dbSNP
rs1415130036 358 dbSNP
rs923460925 360 dbSNP
rs1169997643 370 dbSNP
rs1397920559 370 dbSNP
rs1409862502 375 dbSNP
rs1196766509 376 dbSNP
rs1326985409 382 dbSNP
rs1398651260 399 dbSNP
rs976616051 403 dbSNP
rs1415428641 407 dbSNP
rs1292909959 413 dbSNP
rs922977014 418 dbSNP
rs886055024 419 dbSNP
rs945817019 421 dbSNP
rs914734444 422 dbSNP
rs117664297 424 dbSNP
rs1270547546 430 dbSNP
rs1162164624 431 dbSNP
rs1338723722 431 dbSNP
rs1442189891 434 dbSNP
rs910934964 445 dbSNP
rs1178908505 446 dbSNP
rs985195140 447 dbSNP
rs886055023 451 dbSNP
rs1489066273 453 dbSNP
rs1231377097 454 dbSNP
rs1457038869 455 dbSNP
rs537286454 460 dbSNP
rs1026639131 467 dbSNP
rs577593958 468 dbSNP
rs1452111601 469 dbSNP
rs961632203 472 dbSNP
rs763021259 473 dbSNP
rs971425106 477 dbSNP
rs1243896307 478 dbSNP
rs558028944 482 dbSNP
rs1025639664 492 dbSNP
rs1356004950 493 dbSNP
rs773177098 494 dbSNP
rs898615589 495 dbSNP
rs1233016824 501 dbSNP
rs1277537783 506 dbSNP
rs1355466676 510 dbSNP
rs1205375656 512 dbSNP
rs1013807487 513 dbSNP
rs185578095 516 dbSNP
rs77199262 517 dbSNP
rs867932233 518 dbSNP
rs1455081053 521 dbSNP
rs889004616 526 dbSNP
rs1173136654 527 dbSNP
rs1393373022 529 dbSNP
rs56115495 531 dbSNP
rs1159374402 533 dbSNP
rs1000979898 534 dbSNP
rs1349834741 537 dbSNP
rs534739269 540 dbSNP
rs565605248 544 dbSNP
rs1041436499 548 dbSNP
rs945764702 552 dbSNP
rs368739652 553 dbSNP
rs990293978 556 dbSNP
rs1301093758 565 dbSNP
rs945361051 567 dbSNP
rs937537378 573 dbSNP
rs768484280 576 dbSNP
rs927498008 584 dbSNP
rs943510502 592 dbSNP
rs886055022 593 dbSNP
rs910744541 606 dbSNP
rs1469148905 610 dbSNP
rs981715375 616 dbSNP
rs985165637 619 dbSNP
rs1420973315 621 dbSNP
rs567730190 630 dbSNP
rs1245887458 634 dbSNP
rs1363510437 636 dbSNP
rs1451860999 638 dbSNP
rs547612425 642 dbSNP
rs1220208986 643 dbSNP
rs1166895387 646 dbSNP
rs1394966494 648 dbSNP
rs1460688456 651 dbSNP
rs1323808902 652 dbSNP
rs180737925 656 dbSNP
rs972333843 662 dbSNP
rs1305666108 671 dbSNP
rs1286849274 672 dbSNP
rs961084008 674 dbSNP
rs746664114 680 dbSNP
rs545195226 681 dbSNP
rs1220014188 685 dbSNP
rs746701592 687 dbSNP
rs959452957 689 dbSNP
rs1033546085 690 dbSNP
rs1196503642 696 dbSNP
rs962747146 697 dbSNP
rs1281767024 706 dbSNP
rs551758530 707 dbSNP
rs1418759128 716 dbSNP
rs1402461747 723 dbSNP
rs1474764085 729 dbSNP
rs886055021 730 dbSNP
rs1462405044 739 dbSNP
rs1361667741 740 dbSNP
rs577714302 742 dbSNP
rs1416018093 746 dbSNP
rs1006431082 758 dbSNP
rs888955031 761 dbSNP
rs1233132332 764 dbSNP
rs1029279673 767 dbSNP
rs1310991052 769 dbSNP
rs1298279847 771 dbSNP
rs1309838535 779 dbSNP
rs1452380782 783 dbSNP
rs1343092573 792 dbSNP
rs1177849554 794 dbSNP
rs1251202272 795 dbSNP
rs1482115208 799 dbSNP
rs997432620 800 dbSNP
rs1258552625 801 dbSNP
rs1414648892 803 dbSNP
rs1424280232 806 dbSNP
rs901785652 807 dbSNP
rs1185579319 811 dbSNP
rs1421361031 812 dbSNP
rs1041387211 813 dbSNP
rs1196950813 818 dbSNP
rs1009926048 820 dbSNP
rs892862321 821 dbSNP
rs1371211543 828 dbSNP
rs1007839338 843 dbSNP
rs1193072500 846 dbSNP
rs138656848 847 dbSNP
rs1049260898 859 dbSNP
rs371522224 863 dbSNP
rs1364558065 868 dbSNP
rs1257805036 874 dbSNP
rs1383059291 876 dbSNP
rs62177807 878 dbSNP
rs1311814799 883 dbSNP
rs542776580 892 dbSNP
rs1036758598 896 dbSNP
rs1261675794 907 dbSNP
rs745335688 910 dbSNP
rs1243994267 924 dbSNP
rs1046348644 926 dbSNP
rs1486080205 927 dbSNP
rs1185702786 937 dbSNP
rs1278066808 940 dbSNP
rs1380997103 945 dbSNP
rs950311360 946 dbSNP
rs918856182 948 dbSNP
rs1173775987 954 dbSNP
rs1393983689 955 dbSNP
rs1432284775 957 dbSNP
rs972678373 963 dbSNP
rs962691170 966 dbSNP
rs758197283 967 dbSNP
rs1160841886 968 dbSNP
rs145794135 974 dbSNP
rs1404820466 984 dbSNP
rs985562301 988 dbSNP
rs959357631 992 dbSNP
rs1466949048 994 dbSNP
rs1288647796 1004 dbSNP
rs1424047171 1005 dbSNP
rs868768322 1014 dbSNP
rs1363692732 1016 dbSNP
rs149479224 1030 dbSNP
rs926528647 1031 dbSNP
rs954306489 1037 dbSNP
rs979224788 1038 dbSNP
rs1028814583 1055 dbSNP
rs1217489369 1060 dbSNP
rs997784419 1068 dbSNP
rs137963707 1070 dbSNP
rs577557529 1073 dbSNP
rs966427935 1077 dbSNP
rs1018982324 1082 dbSNP
rs1009872211 1083 dbSNP
rs756614675 1084 dbSNP
rs1194223755 1085 dbSNP
rs1182462977 1086 dbSNP
rs150328867 1087 dbSNP
rs1408346798 1090 dbSNP
rs1054562883 1097 dbSNP
rs1001278499 1104 dbSNP
rs6756388 1105 dbSNP
rs1200937712 1107 dbSNP
rs189771746 1117 dbSNP
rs886055020 1124 dbSNP
rs1257785375 1142 dbSNP
rs1327179710 1149 dbSNP
rs1225958511 1152 dbSNP
rs555716228 1165 dbSNP
rs950274919 1167 dbSNP
rs1394376305 1168 dbSNP
rs1324011386 1175 dbSNP
rs918803310 1182 dbSNP
rs1037250379 1185 dbSNP
rs941657638 1187 dbSNP
rs570014704 1188 dbSNP
rs765182929 1189 dbSNP
rs985895051 1193 dbSNP
rs1286644336 1196 dbSNP
rs113363009 1197 dbSNP
rs866545415 1198 dbSNP
rs1396071128 1204 dbSNP
rs79572907 1205 dbSNP
rs939818228 1206 dbSNP
rs1206056369 1209 dbSNP
rs370472018 1211 dbSNP
rs975912847 1213 dbSNP
rs965876486 1216 dbSNP
rs1400851711 1224 dbSNP
rs60399987 1225 dbSNP
rs1419485736 1230 dbSNP
rs1476424922 1239 dbSNP
rs1010149772 1246 dbSNP
rs926497445 1260 dbSNP
rs1404075570 1263 dbSNP
rs1460417344 1275 dbSNP
rs367918519 1278 dbSNP
rs957303200 1280 dbSNP
rs1441487296 1282 dbSNP
rs1306422051 1286 dbSNP
rs1357588415 1295 dbSNP
rs1233741059 1302 dbSNP
rs1165610068 1308 dbSNP
rs1292413226 1309 dbSNP
rs1354221388 1310 dbSNP
rs1032660057 1311 dbSNP
rs1216278162 1316 dbSNP
rs1273581526 1320 dbSNP
rs554239706 1321 dbSNP
rs533993431 1326 dbSNP
rs1259264499 1330 dbSNP
rs1383432613 1335 dbSNP
rs571725698 1336 dbSNP
rs1368278665 1338 dbSNP
rs905581988 1341 dbSNP
rs1024481482 1347 dbSNP
rs551453985 1366 dbSNP
rs1429250116 1371 dbSNP
rs897329282 1372 dbSNP
rs1037197771 1378 dbSNP
rs1238011273 1386 dbSNP
rs1415600851 1388 dbSNP
rs1194376276 1393 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions Hela
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1048187. RNA binding protein: AGO2. Condition:Hela_AGO2_CLIP_control ...

- Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al., 2013, Cell.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' caggguucucggacugaACACu 5'
                           |||| 
Target 5' -----------------UGUGa 3'
1 - 5
2
miRNA  3' caGGGUUCUCGGACUGAACacu 5'
            ||||| ||:   :|| |   
Target 5' cuCCCAA-AGU---GCUGGg-- 3'
21 - 36
Article - Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al.
- Cell, 2013
The induction of pluripotency or trans-differentiation of one cell type to another can be accomplished with cell-lineage-specific transcription factors. Here, we report that repression of a single RNA binding polypyrimidine-tract-binding (PTB) protein, which occurs during normal brain development via the action of miR-124, is sufficient to induce trans-differentiation of fibroblasts into functional neurons. Besides its traditional role in regulated splicing, we show that PTB has a previously undocumented function in the regulation of microRNA functions, suppressing or enhancing microRNA targeting by competitive binding on target mRNA or altering local RNA secondary structure. A key event during neuronal induction is the relief of PTB-mediated blockage of microRNA action on multiple components of the REST complex, thereby derepressing a large array of neuronal genes, including miR-124 and multiple neuronal-specific transcription factors, in nonneuronal cells. This converts a negative feedback loop to a positive one to elicit cellular reprogramming to the neuronal lineage.
LinkOut: [PMID: 23313552]
CLIP-seq Support 1 for dataset GSM1048187
Method / RBP HITS-CLIP / AGO2
Cell line / Condition Hela / Hela_AGO2_CLIP_control
Location of target site ENST00000243344.7 | 3UTR | UGUGAUCCACCUGCCUCGGCCUCCCAAAGUGCUGGG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23313552 / GSE42701
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE28544 Breast cancer -0.615 6.9e-4 -0.533 3.7e-3 24 Click to see details
GSE21687 Ependynoma primary tumors 0.241 2.8e-2 0.191 6.5e-2 64 Click to see details
GSE32688 Pancreatic cancer -0.332 3.2e-2 -0.247 8.6e-2 32 Click to see details
GSE19783 ER+ ER+ breast cancer 0.339 7.2e-2 0.141 2.8e-1 20 Click to see details
GSE21032 Prostate cancer -0.131 1.2e-1 -0.157 7.8e-2 83 Click to see details
GSE26953 Aortic valvular endothelial cells -0.233 1.4e-1 -0.089 3.4e-1 24 Click to see details
GSE38974 Chronic obstructive pulmonary disease 0.219 1.5e-1 0.195 1.8e-1 25 Click to see details
GSE15076 Monocyte-derived dendritic cells -0.873 1.6e-1 -0.500 3.3e-1 3 Click to see details
GSE19783 ER- ER- breast cancer -0.112 1.6e-1 -0.067 2.8e-1 79 Click to see details
GSE19536 Breast cancer -0.054 3.0e-1 -0.049 3.1e-1 100 Click to see details
GSE38226 Liver fibrosis 0.082 3.6e-1 0.107 3.2e-1 21 Click to see details
GSE19350 CNS germ cell tumors 0.109 3.7e-1 0.117 3.6e-1 12 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis 0.035 4.4e-1 0.254 1.4e-1 20 Click to see details
GSE35602 Colorectal cancer stromal tissue -0.023 4.6e-1 0.131 2.7e-1 25 Click to see details
GSE28260 Renal cortex and medulla 0.024 4.7e-1 -0.077 4.0e-1 13 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
LUAD -0.683 0.01 -0.615 0.02 12 Click to see details
LIHC -0.268 0.03 -0.238 0.05 49 Click to see details
ESCA 0.497 0.06 0.427 0.1 11 Click to see details
BRCA -0.128 0.12 -0.070 0.26 84 Click to see details
KIRP 0.201 0.13 0.233 0.1 32 Click to see details
KICH -0.229 0.14 -0.198 0.17 25 Click to see details
STAD 0.194 0.14 0.191 0.15 32 Click to see details
PRAD 0.145 0.16 0.227 0.06 50 Click to see details
THCA 0.122 0.18 0.212 0.05 59 Click to see details
HNSC -0.142 0.18 -0.133 0.2 42 Click to see details
BLCA 0.222 0.19 0.216 0.19 18 Click to see details
UCEC 0.211 0.19 0.147 0.27 19 Click to see details
PAAD -0.6 0.2 -0.200 0.4 4 Click to see details
PCPG 0.739 0.24 0.500 0.33 3 Click to see details
COAD 0.215 0.3 0.214 0.31 8 Click to see details
CHOL 0.144 0.36 0.017 0.48 9 Click to see details
LUSC 0.053 0.38 0.053 0.38 38 Click to see details
CESC 0.221 0.43 0.500 0.33 3 Click to see details
KIRC 0.012 0.46 -0.005 0.48 68 Click to see details
KIRC 0.012 0.46 -0.005 0.48 68 Click to see details
KIRC 0.012 0.46 -0.005 0.48 68 Click to see details
91 hsa-miR-125b-2-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT038624 HN1L Jupiter microtubule associated homolog 2 1 1
MIRT038625 KDELC2 KDEL motif containing 2 1 1
MIRT038626 ABHD15 abhydrolase domain containing 15 1 1
MIRT038627 PPP1R12C protein phosphatase 1 regulatory subunit 12C 1 1
MIRT038628 MSANTD4 Myb/SANT DNA binding domain containing 4 with coiled-coils 1 1
MIRT038629 ASH2L ASH2 like histone lysine methyltransferase complex subunit 1 1
MIRT038630 USP22 ubiquitin specific peptidase 22 1 1
MIRT038631 CSTB cystatin B 1 1
MIRT038632 SYT2 synaptotagmin 2 1 1
MIRT038633 NDUFS7 NADH:ubiquinone oxidoreductase core subunit S7 1 1
MIRT038634 MTA2 metastasis associated 1 family member 2 1 1
MIRT053086 IGF1R insulin like growth factor 1 receptor 3 1
MIRT055788 PLEKHA1 pleckstrin homology domain containing A1 2 12
MIRT061248 AMOTL1 angiomotin like 1 2 10
MIRT061649 BTG2 BTG anti-proliferation factor 2 2 6
MIRT079046 TNRC6C trinucleotide repeat containing 6C 2 4
MIRT084583 BCL2L11 BCL2 like 11 2 8
MIRT093523 GALNT7 polypeptide N-acetylgalactosaminyltransferase 7 2 2
MIRT097383 LHFPL2 LHFPL tetraspan subfamily member 2 2 4
MIRT098030 SOBP sine oculis binding protein homolog 2 2
MIRT186262 TCEB3 elongin A 2 2
MIRT187284 DAZAP2 DAZ associated protein 2 2 10
MIRT361113 LRRC1 leucine rich repeat containing 1 2 2
MIRT443585 FAM84B family with sequence similarity 84 member B 2 2
MIRT452249 TRAM1 translocation associated membrane protein 1 2 2
MIRT476289 GMFB glia maturation factor beta 2 8
MIRT483871 MRPL12 mitochondrial ribosomal protein L12 2 2
MIRT484250 ANK1 ankyrin 1 2 2
MIRT499251 VAV3 vav guanine nucleotide exchange factor 3 2 4
MIRT502270 HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 2 4
MIRT504652 RPL9 ribosomal protein L9 2 6
MIRT505210 UBN2 ubinuclein 2 2 6
MIRT512690 POP1 POP1 homolog, ribonuclease P/MRP subunit 2 2
MIRT517341 ZNF529 zinc finger protein 529 2 4
MIRT518946 LSG1 large 60S subunit nuclear export GTPase 1 2 2
MIRT520866 SUGT1 SGT1 homolog, MIS12 kinetochore complex assembly cochaperone 2 2
MIRT521236 SAR1A secretion associated Ras related GTPase 1A 2 2
MIRT528324 GIGYF2 GRB10 interacting GYF protein 2 2 2
MIRT533297 USP46 ubiquitin specific peptidase 46 2 2
MIRT541024 WEE1 WEE1 G2 checkpoint kinase 2 4
MIRT544034 ERRFI1 ERBB receptor feedback inhibitor 1 2 2
MIRT547037 POGZ pogo transposable element derived with ZNF domain 2 2
MIRT556102 MOAP1 modulator of apoptosis 1 2 2
MIRT558320 DR1 down-regulator of transcription 1 2 2
MIRT558520 CSRNP3 cysteine and serine rich nuclear protein 3 2 2
MIRT566230 PTMA prothymosin, alpha 2 4
MIRT568437 ARPP19 cAMP regulated phosphoprotein 19 2 2
MIRT570584 OTUD7B OTU deubiquitinase 7B 2 2
MIRT571384 JKAMP JNK1/MAPK8-associated membrane protein 2 2
MIRT572798 SIGLEC14 sialic acid binding Ig like lectin 14 2 2
MIRT573864 C9orf78 chromosome 9 open reading frame 78 2 2
MIRT609930 SLC38A1 solute carrier family 38 member 1 2 4
MIRT610437 CSMD2 CUB and Sushi multiple domains 2 2 2
MIRT614407 MURC caveolae associated protein 4 2 2
MIRT618625 GREB1 growth regulation by estrogen in breast cancer 1 2 2
MIRT620605 SAP30 Sin3A associated protein 30 2 2
MIRT635313 FAM179A TOG array regulator of axonemal microtubules 2 2 2
MIRT635918 GLTSCR2 NOP53 ribosome biogenesis factor 2 2
MIRT638507 MAP3K9 mitogen-activated protein kinase kinase kinase 9 2 2
MIRT640597 TM9SF4 transmembrane 9 superfamily member 4 2 2
MIRT644066 IQCE IQ motif containing E 2 2
MIRT648287 TRAPPC2L trafficking protein particle complex 2 like 2 2
MIRT653089 SSR3 signal sequence receptor subunit 3 2 2
MIRT654651 PTAFR platelet activating factor receptor 2 2
MIRT658084 FOXR2 forkhead box R2 2 2
MIRT665306 ZBTB37 zinc finger and BTB domain containing 37 2 2
MIRT665974 SYTL4 synaptotagmin like 4 2 2
MIRT674905 RASSF9 Ras association domain family member 9 2 2
MIRT680085 THAP1 THAP domain containing 1 2 2
MIRT681487 DIP2A disco interacting protein 2 homolog A 2 2
MIRT691243 DFNB59 pejvakin 2 2
MIRT692361 AGTRAP angiotensin II receptor associated protein 2 2
MIRT693034 MB21D1 Mab-21 domain containing 1 2 2
MIRT694478 LRTOMT leucine rich transmembrane and O-methyltransferase domain containing 2 2
MIRT696069 ZNF264 zinc finger protein 264 2 2
MIRT696579 TTC21B tetratricopeptide repeat domain 21B 2 2
MIRT696759 MTFMT mitochondrial methionyl-tRNA formyltransferase 2 2
MIRT697306 ZNF652 zinc finger protein 652 2 2
MIRT698736 STX12 syntaxin 12 2 2
MIRT701055 PARP2 poly(ADP-ribose) polymerase 2 2 2
MIRT701197 OTUD3 OTU deubiquitinase 3 2 2
MIRT701334 NSD1 nuclear receptor binding SET domain protein 1 2 2
MIRT703617 FBXO45 F-box protein 45 2 2
MIRT708893 ZNF780A zinc finger protein 780A 2 2
MIRT711621 DGKH diacylglycerol kinase eta 2 2
MIRT713744 TMEM81 transmembrane protein 81 2 2
MIRT715060 TMTC1 transmembrane and tetratricopeptide repeat containing 1 2 2
MIRT719711 CD101 CD101 molecule 2 2
MIRT720293 DLGAP3 DLG associated protein 3 2 2
MIRT722605 CCDC152 coiled-coil domain containing 152 2 2
MIRT724565 ACSBG1 acyl-CoA synthetase bubblegum family member 1 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-125b-2 Ascorbate approved 54670067 Microarray Metastatic melanoma cell lines 25202679 2014 up-regualted
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-125b-2 Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-mir-125b-2 Methotrexate 126941 NSC740 approved resistant High Colorectal Adenocarcinoma cell line (HT-29)
hsa-mir-125b-2 Imatinib 5291 NSC743414 approved resistant High Chronic Myelogenous Leukemia tissue
hsa-mir-125b-2 Doxorubicin 31703 NSC123127 approved sensitive Low Hepatocellular Carcinoma cell line (Huh-7, HLE, HuH1)
hsa-mir-125b-2 Dabrafenib 44462760 NSC764134 approved resistant High Melanoma cell line (A375)
hsa-mir-125b-2 Dabrafenib 44462760 NSC764134 approved resistant cell line (A375)
hsa-mir-125b-2 Paclitaxel 36314 NSC125973 approved resistant cell line (W1)
hsa-mir-125b-2 Topotecan 60699 NSC609699 approved resistant cell line (W1)
hsa-mir-125b-2 Vincristine 5978 approved resistant cell line (W1)
hsa-mir-125b-2 Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)
hsa-mir-125b-2 Tamoxifen 2733525 NSC180973 approved resistant tissue (ER-positive breast cancer)
hsa-mir-125b-2 Tamoxifen 2733525 NSC180973 approved sensitive cell line (MCF7)
hsa-mir-125b-2 Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-miR-125b-2-3p Platinum 23939 resistant High Ovarian Cancer tissue
hsa-miR-125b-2-3p Cisplatin 5460033 NSC119875 approved sensitive Low Cervical Cancer tissue
hsa-miR-125b-2-3p Cisplatin 5460033 NSC119875 approved resistant High Gastric Cancer cell line (BGC823)
hsa-miR-125b-2-3p Cisplatin 5460033 NSC119875 approved resistant High Gastric Cancer cell line (SGC-7901)
hsa-miR-125b-2-3p Vemurafenib 42611257 NSC761431 approved sensitive High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-125b-2-3p Dabrafenib 44462760 NSC764134 approved sensitive High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-125b-2-3p Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-miR-125b-2-3p Cisplatin 5460033 NSC119875 approved resistant High Gastric Cancer tissue
hsa-miR-125b-2-3p Fluorouracil 3385 NSC19893 approved resistant High Gastric Cancer tissue
hsa-miR-125b-2-3p Cyclophosphamide + Doxorubicin + Vincristine + Prednisone + Rituximab resistant High Diffuse Large B-Cell Lymphoma cell line (SU-DHL-2)
hsa-miR-125b-2-3p Cisplatin 5460033 NSC119875 approved resistant High Gastric Cancer cell line (SGC-7901, BGC-823)
hsa-miR-125b-2-3p Cisplatin 5460033 NSC119875 approved resistant High Lung Adenocarcinoma cell line (A549)
hsa-miR-125b-2-3p Oxaliplatin 6857599 NSC266046 approved sensitive Low Colorectal Cancer cell line (HCT8, HCT-116)
hsa-miR-125b-2-3p Cisplatin 5460033 NSC119875 approved resistant High Ovarian Cancer cell line (A2780)
hsa-miR-125b-2-3p Antiepileptic Drug sensitive High Pediatric Epilepsy tissue
hsa-miR-125b-2-3p Vemurafenib 42611257 NSC761431 approved sensitive cell line (451Lu)
hsa-miR-125b-2-3p Gefitinib 123631 NSC715055 approved sensitive cell line (HCC827)
hsa-miR-125b-2-3p Cisplatin 5460033 NSC119875 approved resistant cell line (A549)
hsa-miR-125b-2-3p Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)
hsa-miR-125b-2-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-miR-125b-2-3p 4-Hydroxytamoxifen+Tamoxifen resistant cell line (LY2)
hsa-miR-125b-2-3p Ethanol+Tamoxifen resistant cell line (LY2)
hsa-miR-125b-2-3p Methotrexate 126941 NSC740 approved resistant cell line (HT29)
hsa-miR-125b-2-3p Sunitinib 5329102 NSC750690 approved resistant tissue (CardB)
hsa-miR-125b-2-3p Cisplatin 5460033 NSC119875 approved resistant cell line (A549)
hsa-miR-125b-2-3p Oxaliplatin 6857599 NSC266046 approved resistant cell line (IGROV-1)
hsa-miR-125b-2-3p Cisplatin 5460033 NSC119875 approved resistant cell line (IGROV-1)
hsa-miR-125b-2-3p Paclitaxel 36314 NSC125973 approved resistant cell line (PC3PR70)
hsa-miR-125b-2-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-125b-2-3p Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (1500 ng/ml)
hsa-miR-125b-2-3p Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (100 ng/ml)
hsa-miR-125b-2-3p Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-miR-125b-2-3p Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)
hsa-miR-125b-2-3p Cisplatin 5460033 NSC119875 approved resistant cell line (SGC-7901)
hsa-miR-125b-2-3p Cisplatin 5460033 NSC119875 approved resistant cell line (BGC-823)

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