pre-miRNA Information
pre-miRNA hsa-mir-6751   
Genomic Coordinates chr11: 65129916 - 65129978
Description Homo sapiens miR-6751 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-6751-3p
Sequence 43| ACUGAGCCUCUCUCUCUCCAG |63
Evidence Experimental
Experiments Meta-analysis
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSM6795708 8 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs749989972 2 dbSNP
rs1266150108 3 dbSNP
rs1488089412 6 dbSNP
rs1259846893 8 dbSNP
rs3802937 10 dbSNP
rs371083440 12 dbSNP
rs1264909843 13 dbSNP
rs751042478 14 dbSNP
rs757551063 19 dbSNP
Putative Targets

Gene Information
Gene Symbol TAX1BP3   
Synonyms TIP-1, TIP1
Description Tax1 binding protein 3
Transcript NM_014604   
Expression
Putative miRNA Targets on TAX1BP3
3'UTR of TAX1BP3
(miRNA target sites are highlighted)
>TAX1BP3|NM_014604|3'UTR
   1 CAGCCACCACCATCTGCGACTCCTGCCTGCCGCCTCTCTGTACAGTAACGCCACTTCCACACTCTGTCCCCATCTGGCTT
  81 CTGCTGACCGCTGGGCCCCAGCTCAGAAGGGCTATAGCTGGTCCCAGAGGCCTGGCCTGGCCTTCCTTCCCTTCTCCCAT
 161 CCCTGGCCTGGGGCCTCTGGGACCGGCTTTCTCTCCTGGACACCGAGGATTGGAAATAAGGGCCTGGAGCTGAGTAGTAG
 241 CCAGTCTGCTGTGACCACAGGCTCAGGTCCGACCCTGCTGCTTGGCCACAGCAGTGGCTGGGCAAGTGGGAACCACTATC
 321 TCTTGGGAGCCCCCAAAAGCTGGGAAATGCTGGAGGAACCAGGCCTTTCCCGCTTTTGCCTGGCTGCAGGGTTCGGCTCC
 401 GCCCCTGCCCCCCAGCCCTCGTGTGTCCACACCGCAGTGCCTCTGCCCCTCGGGGGACTGGACACACATCCTGCCAGAGG
 481 CGCTACGAAGCTTTGCCCAGATGAAGCCAGGTGGGCTCCGCGTTCACTCCCACTCTCCCGAGGGGTGCTGGCCTCCCCAG
 561 GGTTTGCCTTCTTACGGATTTAGACGAGGTTCGAGGCTCACCTATCAGGGCAGCTCTCAGGATTGTCATTTTCCTCTTTG
 641 CCTGTGGGTTTAACTTTTGTATTTTTTTAATCACAAGTTTGATACAAAATGTTTTTATCGTACTCTTTGGAGATGCCCAT
 721 TCTACTTTTGAATTTAGCTTTTACTAATTCGCATCTGGAAGCTCAGCAAGTGCACAAGCCTTACTTTGGTTACCGTGGAA
 801 ACCACTGCCGCCCCTCCCCGATGTGGTGCGCTCAATAAAAATGCTGGAATTCACAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' gaccuCUCU-CUCUCCGAGUCa 5'
               | ||  | |||||||| 
Target 5' ctgctGTGACCACAGGCTCAGg 3'
246 - 267 148.00 -15.20
2
miRNA  3' gaccUCU-CUCU---CUCCGAGUca 5'
              ||| |||:   ||||||||  
Target 5' atttAGACGAGGTTCGAGGCTCAcc 3'
578 - 602 141.00 -16.60
3
miRNA  3' gaCCUCUCUCUCUCCGAGUCa 5'
            | ||  ||: :||||| | 
Target 5' atGAAGCCAGGTGGGCTCCGc 3'
501 - 521 123.00 -11.60
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
322925 662 ClinVar
322924 717 ClinVar
322923 751 ClinVar
322922 786 ClinVar
322921 795 ClinVar
322920 810 ClinVar
889571 811 ClinVar
322919 829 ClinVar
322918 833 ClinVar
322917 852 ClinVar
COSN30449993 18 COSMIC
COSN24292763 38 COSMIC
COSN30469972 49 COSMIC
COSN30130399 50 COSMIC
COSN24292800 64 COSMIC
COSN8835763 449 COSMIC
COSN20113281 551 COSMIC
COSN27161796 677 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs754539319 1 dbSNP
rs373003870 2 dbSNP
rs766395944 4 dbSNP
rs762794076 5 dbSNP
rs1309914710 7 dbSNP
rs113023181 10 dbSNP
rs1385609865 12 dbSNP
rs764992409 14 dbSNP
rs761543066 17 dbSNP
rs887071356 18 dbSNP
rs1190514619 19 dbSNP
rs774945397 27 dbSNP
rs1186863710 29 dbSNP
rs772228029 30 dbSNP
rs573476484 31 dbSNP
rs557023285 32 dbSNP
rs771511309 37 dbSNP
rs1290992288 39 dbSNP
rs771426320 42 dbSNP
rs1354840976 46 dbSNP
rs763406119 47 dbSNP
rs185656029 49 dbSNP
rs373420100 50 dbSNP
rs1436437007 54 dbSNP
rs558916688 55 dbSNP
rs1349603241 61 dbSNP
rs926377097 62 dbSNP
rs539007064 63 dbSNP
rs1280898478 65 dbSNP
rs1364945422 66 dbSNP
rs1218140300 70 dbSNP
rs1179780694 71 dbSNP
rs1484007493 77 dbSNP
rs979135035 86 dbSNP
rs1237670754 87 dbSNP
rs1272992122 89 dbSNP
rs535043308 90 dbSNP
rs1205573379 93 dbSNP
rs1234804588 95 dbSNP
rs1456273164 98 dbSNP
rs1259918291 99 dbSNP
rs913603030 106 dbSNP
rs1219100734 131 dbSNP
rs553489424 136 dbSNP
rs1166619210 144 dbSNP
rs375484520 147 dbSNP
rs1430148578 155 dbSNP
rs746781689 156 dbSNP
rs1347759491 160 dbSNP
rs990918486 161 dbSNP
rs1274949483 162 dbSNP
rs1380232184 165 dbSNP
rs779949757 167 dbSNP
rs567838506 174 dbSNP
rs1296039039 179 dbSNP
rs550854679 184 dbSNP
rs11541134 185 dbSNP
rs571818284 186 dbSNP
rs1005559733 193 dbSNP
rs1275475569 193 dbSNP
rs887188970 196 dbSNP
rs890345691 197 dbSNP
rs1051613402 198 dbSNP
rs1189441357 201 dbSNP
rs1162139210 204 dbSNP
rs551370479 205 dbSNP
rs1475659619 211 dbSNP
rs1414155220 212 dbSNP
rs528060035 218 dbSNP
rs1014657223 226 dbSNP
rs1176200441 234 dbSNP
rs1437608354 240 dbSNP
rs559048162 244 dbSNP
rs1323770842 245 dbSNP
rs1396120743 248 dbSNP
rs1056423892 250 dbSNP
rs941740560 251 dbSNP
rs907530837 262 dbSNP
rs368690979 270 dbSNP
rs1263589785 271 dbSNP
rs1272315322 273 dbSNP
rs937494102 280 dbSNP
rs1228006026 289 dbSNP
rs778440638 292 dbSNP
rs1337146437 294 dbSNP
rs1047353434 300 dbSNP
rs1238678064 303 dbSNP
rs542308097 308 dbSNP
rs949650291 311 dbSNP
rs867889062 312 dbSNP
rs946489181 314 dbSNP
rs1322405201 320 dbSNP
rs1235561458 335 dbSNP
rs913625386 355 dbSNP
rs1165266826 356 dbSNP
rs1238171463 367 dbSNP
rs529096564 371 dbSNP
rs1310403446 373 dbSNP
rs1440593081 374 dbSNP
rs1384991468 376 dbSNP
rs756775442 394 dbSNP
rs922563728 395 dbSNP
rs1447750327 399 dbSNP
rs8069855 400 dbSNP
rs979920751 401 dbSNP
rs963854461 402 dbSNP
rs1226745699 404 dbSNP
rs1267638773 408 dbSNP
rs966777522 409 dbSNP
rs1206894307 411 dbSNP
rs1441714830 414 dbSNP
rs1458997912 414 dbSNP
rs1016761119 417 dbSNP
rs778308225 420 dbSNP
rs371391827 421 dbSNP
rs1026118827 430 dbSNP
rs1437389036 433 dbSNP
rs1014275091 434 dbSNP
rs1160865984 438 dbSNP
rs895764893 439 dbSNP
rs11541135 443 dbSNP
rs1400692270 448 dbSNP
rs543208656 450 dbSNP
rs577891640 451 dbSNP
rs1034613929 452 dbSNP
rs1408275862 453 dbSNP
rs1179072208 454 dbSNP
rs1306553737 457 dbSNP
rs1336490244 462 dbSNP
rs756662590 464 dbSNP
rs900330807 469 dbSNP
rs1001820069 470 dbSNP
rs1453564530 471 dbSNP
rs879486677 481 dbSNP
rs1016055336 482 dbSNP
rs1006387024 485 dbSNP
rs539807793 486 dbSNP
rs1196166152 488 dbSNP
rs566071385 490 dbSNP
rs868867315 496 dbSNP
rs1052593017 503 dbSNP
rs1260168277 508 dbSNP
rs1174777947 509 dbSNP
rs1377717978 513 dbSNP
rs1428203772 518 dbSNP
rs759897317 519 dbSNP
rs564191603 520 dbSNP
rs975041934 521 dbSNP
rs1356173236 522 dbSNP
rs1286985518 525 dbSNP
rs942643078 529 dbSNP
rs545454046 532 dbSNP
rs573252965 533 dbSNP
rs1305533553 535 dbSNP
rs983930137 539 dbSNP
rs951263651 540 dbSNP
rs11541133 542 dbSNP
rs1367727279 544 dbSNP
rs536753234 550 dbSNP
rs540976119 556 dbSNP
rs993286566 560 dbSNP
rs960142920 561 dbSNP
rs1468534753 569 dbSNP
rs766579107 571 dbSNP
rs1158873548 573 dbSNP
rs149526815 575 dbSNP
rs181419522 576 dbSNP
rs1375668019 583 dbSNP
rs773215882 585 dbSNP
rs557552021 586 dbSNP
rs904806176 588 dbSNP
rs913966731 592 dbSNP
rs537211435 593 dbSNP
rs955346793 595 dbSNP
rs1191660822 597 dbSNP
rs534853715 601 dbSNP
rs1381525401 606 dbSNP
rs1021856406 607 dbSNP
rs1030288512 608 dbSNP
rs1309003290 616 dbSNP
rs1010430053 617 dbSNP
rs189262692 618 dbSNP
rs1272131264 639 dbSNP
rs1335011275 647 dbSNP
rs1215023436 655 dbSNP
rs567476347 662 dbSNP
rs933771077 664 dbSNP
rs1016519014 669 dbSNP
rs1006028541 671 dbSNP
rs1210366583 683 dbSNP
rs543695304 690 dbSNP
rs900900699 691 dbSNP
rs551633303 695 dbSNP
rs942340018 699 dbSNP
rs1417434522 700 dbSNP
rs1234378600 701 dbSNP
rs1307470003 702 dbSNP
rs1167214021 709 dbSNP
rs909818969 709 dbSNP
rs534360650 717 dbSNP
rs1044804 722 dbSNP
rs1013238286 723 dbSNP
rs1341765672 731 dbSNP
rs929834075 732 dbSNP
rs1395042665 737 dbSNP
rs775575548 750 dbSNP
rs886052886 751 dbSNP
rs1044809 755 dbSNP
rs1372494114 757 dbSNP
rs771938992 765 dbSNP
rs1234693199 766 dbSNP
rs565329659 769 dbSNP
rs1265750666 770 dbSNP
rs938271413 771 dbSNP
rs904073795 773 dbSNP
rs1044811 774 dbSNP
rs549150113 786 dbSNP
rs1478849602 787 dbSNP
rs927349890 794 dbSNP
rs548531950 795 dbSNP
rs968683626 800 dbSNP
rs1021890470 803 dbSNP
rs1044824 804 dbSNP
rs1258503384 809 dbSNP
rs7093 810 dbSNP
rs770525743 811 dbSNP
rs748805722 816 dbSNP
rs1256724099 817 dbSNP
rs1220940453 818 dbSNP
rs1312074786 819 dbSNP
rs563211649 820 dbSNP
rs1030957994 823 dbSNP
rs1286066628 828 dbSNP
rs1128098 829 dbSNP
rs900930401 830 dbSNP
rs1128109 833 dbSNP
rs1006511932 835 dbSNP
rs1396394786 844 dbSNP
rs1209322069 847 dbSNP
rs886052885 852 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions Hela
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1048187. RNA binding protein: AGO2. Condition:Hela_AGO2_CLIP_control ...

- Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al., 2013, Cell.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' gaccuCUCU-CUCUCCGAGuca 5'
               | ||  | ||||||   
Target 5' --gcuGUGACCACAGGCUC--- 3'
1 - 17
Article - Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al.
- Cell, 2013
The induction of pluripotency or trans-differentiation of one cell type to another can be accomplished with cell-lineage-specific transcription factors. Here, we report that repression of a single RNA binding polypyrimidine-tract-binding (PTB) protein, which occurs during normal brain development via the action of miR-124, is sufficient to induce trans-differentiation of fibroblasts into functional neurons. Besides its traditional role in regulated splicing, we show that PTB has a previously undocumented function in the regulation of microRNA functions, suppressing or enhancing microRNA targeting by competitive binding on target mRNA or altering local RNA secondary structure. A key event during neuronal induction is the relief of PTB-mediated blockage of microRNA action on multiple components of the REST complex, thereby derepressing a large array of neuronal genes, including miR-124 and multiple neuronal-specific transcription factors, in nonneuronal cells. This converts a negative feedback loop to a positive one to elicit cellular reprogramming to the neuronal lineage.
LinkOut: [PMID: 23313552]
CLIP-seq Support 1 for dataset GSM1048187
Method / RBP HITS-CLIP / AGO2
Cell line / Condition Hela / Hela_AGO2_CLIP_control
Location of target site ENST00000225525.3 | 3UTR | GCUGUGACCACAGGCUC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23313552 / GSE42701
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
77 hsa-miR-6751-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT130738 GATAD2B GATA zinc finger domain containing 2B 2 4
MIRT134924 CCND2 cyclin D2 2 2
MIRT273034 ZBTB18 zinc finger and BTB domain containing 18 2 2
MIRT276645 KPNA3 karyopherin subunit alpha 3 2 6
MIRT446531 OAS2 2'-5'-oligoadenylate synthetase 2 2 2
MIRT456268 TDRKH tudor and KH domain containing 2 12
MIRT494454 BTG2 BTG anti-proliferation factor 2 2 2
MIRT494965 USP46 ubiquitin specific peptidase 46 2 2
MIRT496689 KREMEN1 kringle containing transmembrane protein 1 2 2
MIRT496697 RGS11 regulator of G protein signaling 11 2 2
MIRT504376 IRF4 interferon regulatory factor 4 2 6
MIRT510980 PFN2 profilin 2 2 6
MIRT512548 MFN2 mitofusin 2 2 6
MIRT513639 TP53INP2 tumor protein p53 inducible nuclear protein 2 2 2
MIRT514016 CAMSAP1 calmodulin regulated spectrin associated protein 1 2 4
MIRT514074 MTRNR2L6 MT-RNR2-like 6 2 2
MIRT515300 C15orf38-AP3S2 C15orf38-AP3S2 readthrough 2 4
MIRT517285 AP3S2 adaptor related protein complex 3 sigma 2 subunit 2 4
MIRT519075 KCNK6 potassium two pore domain channel subfamily K member 6 2 2
MIRT520779 TCF23 transcription factor 23 2 2
MIRT522485 MFSD9 major facilitator superfamily domain containing 9 2 2
MIRT528856 PKP1 plakophilin 1 2 2
MIRT529081 PATE2 prostate and testis expressed 2 2 2
MIRT531209 PLA2G4D phospholipase A2 group IVD 2 2
MIRT533988 TAB3 TGF-beta activated kinase 1 and MAP3K7 binding protein 3 2 2
MIRT537024 GRIN2B glutamate ionotropic receptor NMDA type subunit 2B 2 2
MIRT537498 FAM168B family with sequence similarity 168 member B 2 2
MIRT553125 UBE2Z ubiquitin conjugating enzyme E2 Z 2 2
MIRT555591 PIP5K1C phosphatidylinositol-4-phosphate 5-kinase type 1 gamma 2 2
MIRT556370 LUZP1 leucine zipper protein 1 2 2
MIRT569745 C2orf71 chromosome 2 open reading frame 71 2 2
MIRT570149 DNAJC10 DnaJ heat shock protein family (Hsp40) member C10 2 2
MIRT571243 FADS6 fatty acid desaturase 6 2 2
MIRT573065 TRIB1 tribbles pseudokinase 1 2 2
MIRT575533 Map4 microtubule-associated protein 4 2 2
MIRT575777 Tnfrsf10b tumor necrosis factor receptor superfamily, member 10b 2 2
MIRT616558 ZNF512B zinc finger protein 512B 2 2
MIRT624851 ABI2 abl interactor 2 2 2
MIRT630078 GRWD1 glutamate rich WD repeat containing 1 2 2
MIRT631479 KLHL21 kelch like family member 21 2 2
MIRT632173 CCL22 C-C motif chemokine ligand 22 2 2
MIRT638397 QSOX2 quiescin sulfhydryl oxidase 2 2 4
MIRT641192 ISG20L2 interferon stimulated exonuclease gene 20 like 2 2 2
MIRT642562 TEX9 testis expressed 9 2 2
MIRT642935 KRTAP5-9 keratin associated protein 5-9 2 2
MIRT649703 ZNF175 zinc finger protein 175 2 2
MIRT650437 CPXM2 carboxypeptidase X, M14 family member 2 2 2
MIRT652113 TRUB2 TruB pseudouridine synthase family member 2 2 2
MIRT652273 TOMM20 translocase of outer mitochondrial membrane 20 2 2
MIRT655215 PFKM phosphofructokinase, muscle 2 2
MIRT682778 ZNF852 zinc finger protein 852 2 2
MIRT683001 MUC20 mucin 20, cell surface associated 2 2
MIRT684320 GTF3C4 general transcription factor IIIC subunit 4 2 2
MIRT689435 CYB561 cytochrome b561 2 2
MIRT693847 ZNF107 zinc finger protein 107 2 2
MIRT696715 TAX1BP3 Tax1 binding protein 3 2 2
MIRT698597 TEX261 testis expressed 261 2 2
MIRT699973 RREB1 ras responsive element binding protein 1 2 2
MIRT703310 GFPT1 glutamine--fructose-6-phosphate transaminase 1 2 2
MIRT706796 RAI1 retinoic acid induced 1 2 2
MIRT709004 CD109 CD109 molecule 2 2
MIRT709181 TBC1D10B TBC1 domain family member 10B 2 2
MIRT709835 PAQR7 progestin and adipoQ receptor family member 7 2 2
MIRT711627 CORO1C coronin 1C 2 2
MIRT712634 RNF103-CHMP3 RNF103-CHMP3 readthrough 2 2
MIRT713694 CYB5R4 cytochrome b5 reductase 4 2 2
MIRT713752 SLC9A8 solute carrier family 9 member A8 2 2
MIRT714908 CHMP3 charged multivesicular body protein 3 2 2
MIRT716371 CBLL1 Cbl proto-oncogene like 1 2 2
MIRT718303 XPOT exportin for tRNA 2 2
MIRT718713 ANKRD18A ankyrin repeat domain 18A 2 2
MIRT718740 ATP9A ATPase phospholipid transporting 9A (putative) 2 2
MIRT719441 NPTX2 neuronal pentraxin 2 2 2
MIRT720896 OTUD4 OTU deubiquitinase 4 2 2
MIRT722448 RXFP4 relaxin/insulin like family peptide receptor 4 2 2
MIRT723882 VKORC1 vitamin K epoxide reductase complex subunit 1 2 2
MIRT724586 SYNJ2BP synaptojanin 2 binding protein 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-6751 Cisplatin 5460033 NSC119875 approved sensitive Low Ovarian Cancer cell line (A2780)
hsa-mir-6751 Triptolide 107985 NSC163062 sensitive Low Ovarian Cancer cell line (A2780)

Error report submission