pre-miRNA Information
pre-miRNA hsa-mir-4486   
Genomic Coordinates chr11: 19575310 - 19575372
Description Homo sapiens miR-4486 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4486
Sequence 5| GCUGGGCGAGGCUGGCA |21
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs774299284 8 dbSNP
rs902172817 14 dbSNP
rs1222795726 17 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol ZYG11A   
Synonyms ZYG11
Description zyg-11 family member A, cell cycle regulator
Transcript NM_001004339   
Expression
Putative miRNA Targets on ZYG11A
3'UTR of ZYG11A
(miRNA target sites are highlighted)
>ZYG11A|NM_001004339|3'UTR
   1 ACCTAAGGAATTTCAGAGGTGTGTGCTCTTCCTCAATGTCAGGTGTTCTGCCCTGGCAGTAATTGCACATCAGTTGTCAT
  81 TGGAGTTTGTGAGTTGGCTGTCTCATTGGCCTTTGATTGTTGATTTTATATATGTTACAAAAGGTTGGATTTGTATGATA
 161 GCTGTAATCCCAAGTCAAGTTGGACTCATTCTGCAGCCTTTCAGCAGCAATTTTGAAGACTCAAACCGTGGACTCTGGGA
 241 AGGCCTGGGAGCTTGTGTTGGAACAGCTATGCAAGTTACTTTTCTCTAGCCTTGGACAATTTTTTCCCTTTGGGAGCTTG
 321 TCATGGGAGTGGGACCTGTTCACTAGAAGAGAAAGGAAACCTACAGGGAGACTTTGATATTTATATTAAATTTCCTTTGT
 401 TGTTATCGTCATGTGAAGCTATGAGAAAAGCTTGGGAAGCATATGCTTCAAAATGTAGTGTTTAGAAGGCAGAACCCCTG
 481 TTGGAGAGCGGGGAAAAGAATTTATTTATTTATTTATTTATCTATGGCTGGGTATGGTGGCTCACGCCTGTAATCCCAGC
 561 ACTTTGGGAGGCCAAGGCAGGTGGATTGTCTGAACTCAGGAGTTCGAGATCAGCCTTGCCAACGTGGTAAAACTCCGTCT
 641 CTACCAAAAAATACAAAAATTAGCTGAGCGTGGTGGTGTGCACCTTTACTCCTAGCTACTTGGAGGCTGAGGTGGGAGGA
 721 CCACTTGAGCCCAGGAGGCAGAGGTTGCAGTGAGCTGAGATTGCACCACTGCACTCCAGCCTGGATGACAGAGTGAGACC
 801 TCATCTCAAATGAATAGAGGGGTGGAGAAAAGAGAAATATATTTTTTTACCTTTTTTTTTTTTTTTTTTTTTGTGACGGA
 881 ATCTCGCTCTGTCGCCCAGGCTGGAGTGCAGTGGCACAATCTCGGCTCACTGCAACCTCTGCCTCCCAGGTTCCAGCAAT
 961 TCTCCTGCCTCAGCCTCCTGAGTAGCTGGGACTACAGGCACATGCCGCCACGCCCGGCTAATTTTTGTATTTTTTAGTAG
1041 AGACAGGGTTTCACCATATTGGTCAGGCTGGTCTCGACCTCCTGACCTCGTGATCCACCCGTCTCGGCCTCCCAAAGTGC
1121 TGGGATTACAGGTGTGAGTCACTGCACCTGGCCTTTTTACAATTTTGGGTGTCTATCTTTGGCATGTTTCCTGTTATGTG
1201 AGCATGACATGCTGTGTATGTGAGTGAGCTTGTAGGGCGTGGTGGGACTTAGGCATTTGCAGACAGTGTTTAGATGAAAG
1281 ATTACATGTAATGATAAATCTGAATCCCTCCATTTTATTTGGGTGGAACCATGACCAAAAATGGTAGGAAGACGAAAGGC
1361 CAGAAAGAGACTTTGCCAGAGAGTTCACGGAGTTTTCTTACCCCGCATGCTGACTAAAGAAAACATGGGCTTTTCTGAAA
1441 CCAGCTTCAACTACAGTATAAACTATATCAGAAGCTTACTTGATAAGCCTTGCGGAGCTGCTCTGAGGAATAGTGTGAAT
1521 TCCTTCCTTGCCTTATTGTTGACTGTTAATGAACATGTTTTGTCATTTATCTGTTTAAGTTTTTCAGAAAATAAAAGTAA
1601 ATTTCTGTTAGCACATTTAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' acGGUCGG---AGCGGGUCg 5'
            |: ||:   |||||||| 
Target 5' atCTCGCTCTGTCGCCCAGg 3'
881 - 900 147.00 -16.20
2
miRNA  3' acgGUCGGAGCGGGUCg 5'
             | ||| |||||:| 
Target 5' atgCCGCCACGCCCGGc 3'
1002 - 1018 138.00 -27.30
3
miRNA  3' acggucggagCGGGUCg 5'
                    |||||| 
Target 5' gaccacttgaGCCCAGg 3'
719 - 735 120.00 -15.80
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30117817 67 COSMIC
COSN20073390 70 COSMIC
COSN23704589 477 COSMIC
COSN17326326 499 COSMIC
COSN21324398 731 COSMIC
COSN29302398 793 COSMIC
COSN24805678 1483 COSMIC
COSN6038624 1515 COSMIC
COSN6038625 1530 COSMIC
COSN25348638 1599 COSMIC
COSN1448885 1609 COSMIC
COSN32121592 2035 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1230885022 5 dbSNP
rs1252881636 6 dbSNP
rs1472382626 10 dbSNP
rs553267979 12 dbSNP
rs916690202 15 dbSNP
rs766289865 19 dbSNP
rs1466572558 20 dbSNP
rs1272678011 21 dbSNP
rs1300907789 21 dbSNP
rs1212333603 24 dbSNP
rs1337627461 25 dbSNP
rs1344105520 25 dbSNP
rs1200958289 26 dbSNP
rs1172536401 28 dbSNP
rs577852187 31 dbSNP
rs1444757253 32 dbSNP
rs911241062 35 dbSNP
rs538495718 36 dbSNP
rs753716842 37 dbSNP
rs755090294 38 dbSNP
rs556743729 39 dbSNP
rs1369566766 46 dbSNP
rs1323342598 49 dbSNP
rs1462902495 53 dbSNP
rs1395146708 57 dbSNP
rs1169617603 62 dbSNP
rs1460277031 64 dbSNP
rs913024995 70 dbSNP
rs1442386963 74 dbSNP
rs1429380808 81 dbSNP
rs945871157 85 dbSNP
rs575058393 90 dbSNP
rs756469256 106 dbSNP
rs929991225 108 dbSNP
rs1375199449 112 dbSNP
rs777712296 120 dbSNP
rs1170153906 130 dbSNP
rs925878868 131 dbSNP
rs1227646393 141 dbSNP
rs937265459 142 dbSNP
rs1300557422 144 dbSNP
rs1442472703 154 dbSNP
rs780393794 157 dbSNP
rs542332608 162 dbSNP
rs1371183929 165 dbSNP
rs1328090750 169 dbSNP
rs1389652393 179 dbSNP
rs530388326 180 dbSNP
rs1168315038 181 dbSNP
rs1170936432 194 dbSNP
rs1462645869 194 dbSNP
rs1394706196 198 dbSNP
rs1172078393 203 dbSNP
rs560798201 207 dbSNP
rs371387395 225 dbSNP
rs144036843 228 dbSNP
rs1181677554 229 dbSNP
rs1320226907 231 dbSNP
rs1253037879 234 dbSNP
rs571035804 244 dbSNP
rs1029409618 245 dbSNP
rs1485103640 246 dbSNP
rs1399203766 251 dbSNP
rs1277749385 252 dbSNP
rs1236120190 270 dbSNP
rs1283468160 278 dbSNP
rs554830968 284 dbSNP
rs1036526936 287 dbSNP
rs897298208 288 dbSNP
rs994312401 290 dbSNP
rs1230394413 300 dbSNP
rs967481252 302 dbSNP
rs1329232615 304 dbSNP
rs1254969415 337 dbSNP
rs977070805 339 dbSNP
rs150969152 355 dbSNP
rs1007586952 357 dbSNP
rs1018271917 362 dbSNP
rs1158088761 364 dbSNP
rs1469000815 380 dbSNP
rs958255074 385 dbSNP
rs1306171815 386 dbSNP
rs1183256375 389 dbSNP
rs1255914733 392 dbSNP
rs1212539270 397 dbSNP
rs989663436 400 dbSNP
rs965761531 408 dbSNP
rs535375615 409 dbSNP
rs948165509 411 dbSNP
rs967181424 412 dbSNP
rs747972844 414 dbSNP
rs982645038 419 dbSNP
rs1232653300 426 dbSNP
rs1353297254 431 dbSNP
rs560039816 433 dbSNP
rs1454380706 448 dbSNP
rs925806613 451 dbSNP
rs928064048 455 dbSNP
rs533670349 456 dbSNP
rs775419640 457 dbSNP
rs930001688 460 dbSNP
rs1047027182 476 dbSNP
rs1317643059 477 dbSNP
rs888376302 480 dbSNP
rs771629749 483 dbSNP
rs941247302 487 dbSNP
rs1418838789 488 dbSNP
rs1303573130 490 dbSNP
rs1056158631 491 dbSNP
rs1039511767 495 dbSNP
rs916885978 498 dbSNP
rs747137019 499 dbSNP
rs1036087301 500 dbSNP
rs1190541512 500 dbSNP
rs899700362 500 dbSNP
rs552062448 501 dbSNP
rs1241163497 503 dbSNP
rs1190649229 504 dbSNP
rs563888406 513 dbSNP
rs1448198700 525 dbSNP
rs998019397 528 dbSNP
rs531099535 544 dbSNP
rs1029853448 546 dbSNP
rs1335762842 547 dbSNP
rs187221473 549 dbSNP
rs998541782 551 dbSNP
rs1352204109 559 dbSNP
rs1032652262 563 dbSNP
rs958286409 578 dbSNP
rs6693081 580 dbSNP
rs1048535387 582 dbSNP
rs1023887065 585 dbSNP
rs969995858 587 dbSNP
rs535060384 589 dbSNP
rs1189628926 590 dbSNP
rs1266985255 596 dbSNP
rs1419311110 604 dbSNP
rs1165761250 606 dbSNP
rs1476207697 607 dbSNP
rs1419702943 616 dbSNP
rs982291087 619 dbSNP
rs1467027598 624 dbSNP
rs1018950969 625 dbSNP
rs1378365648 629 dbSNP
rs111589810 638 dbSNP
rs1163963267 644 dbSNP
rs1212990691 645 dbSNP
rs998612565 651 dbSNP
rs1298352082 655 dbSNP
rs1440272258 660 dbSNP
rs1368958280 663 dbSNP
rs951437967 664 dbSNP
rs1437851776 668 dbSNP
rs796699212 670 dbSNP
rs1168802852 671 dbSNP
rs1456202511 675 dbSNP
rs1390407888 678 dbSNP
rs1292540785 679 dbSNP
rs1452021794 681 dbSNP
rs1396792726 690 dbSNP
rs1191673887 691 dbSNP
rs909846859 692 dbSNP
rs941360299 702 dbSNP
rs1306539161 711 dbSNP
rs1206382522 715 dbSNP
rs1375315367 717 dbSNP
rs1239986624 730 dbSNP
rs1275619699 731 dbSNP
rs770617108 741 dbSNP
rs1323840634 742 dbSNP
rs921176571 746 dbSNP
rs1220265100 750 dbSNP
rs1373264364 757 dbSNP
rs1265066379 763 dbSNP
rs1444807573 764 dbSNP
rs958791322 771 dbSNP
rs1481102946 773 dbSNP
rs571573708 777 dbSNP
rs1200594576 779 dbSNP
rs538557929 780 dbSNP
rs574936015 781 dbSNP
rs950019441 784 dbSNP
rs971689666 794 dbSNP
rs1178950764 800 dbSNP
rs1472789751 806 dbSNP
rs1050926347 808 dbSNP
rs1256587930 816 dbSNP
rs1210387475 818 dbSNP
rs902949912 819 dbSNP
rs998574189 820 dbSNP
rs556806946 823 dbSNP
rs1210914372 833 dbSNP
rs1316480474 837 dbSNP
rs542565901 837 dbSNP
rs1226028130 839 dbSNP
rs1351455497 839 dbSNP
rs892847363 841 dbSNP
rs1376915074 842 dbSNP
rs1412486222 842 dbSNP
rs1302853527 843 dbSNP
rs1163871069 849 dbSNP
rs375504742 850 dbSNP
rs1182719295 852 dbSNP
rs1185543299 852 dbSNP
rs1258527921 852 dbSNP
rs1259084192 852 dbSNP
rs1369759029 852 dbSNP
rs1469441466 852 dbSNP
rs1474310294 852 dbSNP
rs1485570843 852 dbSNP
rs1211083382 854 dbSNP
rs1330453136 857 dbSNP
rs1463254179 859 dbSNP
rs1328891539 860 dbSNP
rs1398839253 861 dbSNP
rs1312973894 872 dbSNP
rs1381353174 873 dbSNP
rs1452774734 873 dbSNP
rs1335175643 874 dbSNP
rs1382031666 875 dbSNP
rs1393642413 875 dbSNP
rs1226928839 876 dbSNP
rs1462806420 878 dbSNP
rs1312539800 879 dbSNP
rs1368883104 881 dbSNP
rs1308283851 885 dbSNP
rs1220630546 886 dbSNP
rs1256402730 887 dbSNP
rs796555188 890 dbSNP
rs536057901 894 dbSNP
rs192251589 895 dbSNP
rs1239107240 897 dbSNP
rs1252920949 901 dbSNP
rs1212434208 912 dbSNP
rs1482274949 920 dbSNP
rs12742311 922 dbSNP
rs575011494 924 dbSNP
rs1262098271 925 dbSNP
rs1266433677 936 dbSNP
rs1226174427 937 dbSNP
rs1305415283 938 dbSNP
rs1012581714 944 dbSNP
rs1435180597 946 dbSNP
rs535571407 947 dbSNP
rs1369682446 948 dbSNP
rs1168049517 949 dbSNP
rs1422503794 951 dbSNP
rs555890643 954 dbSNP
rs1469851184 958 dbSNP
rs1024337685 963 dbSNP
rs969642883 976 dbSNP
rs1170797411 979 dbSNP
rs1450158675 984 dbSNP
rs1004130826 991 dbSNP
rs1394608058 997 dbSNP
rs1035158646 1001 dbSNP
rs951466671 1002 dbSNP
rs879277618 1007 dbSNP
rs909961612 1008 dbSNP
rs1268419985 1012 dbSNP
rs962712771 1013 dbSNP
rs572557042 1014 dbSNP
rs975419707 1016 dbSNP
rs1228748670 1017 dbSNP
rs921199112 1022 dbSNP
rs1300666339 1023 dbSNP
rs933894851 1030 dbSNP
rs1235262999 1047 dbSNP
rs1302786923 1057 dbSNP
rs998477336 1060 dbSNP
rs1020290317 1066 dbSNP
rs1389460562 1077 dbSNP
rs541658357 1082 dbSNP
rs1276484357 1085 dbSNP
rs1317572411 1086 dbSNP
rs1374873453 1087 dbSNP
rs1171860412 1088 dbSNP
rs564615274 1090 dbSNP
rs1378712104 1091 dbSNP
rs1280898647 1094 dbSNP
rs1417681902 1097 dbSNP
rs1254466291 1098 dbSNP
rs924400359 1101 dbSNP
rs934481472 1102 dbSNP
rs1054242552 1103 dbSNP
rs578258552 1106 dbSNP
rs1277501093 1107 dbSNP
rs1201678765 1112 dbSNP
rs1345195535 1113 dbSNP
rs1000243887 1116 dbSNP
rs1236859045 1118 dbSNP
rs1033105101 1120 dbSNP
rs545793458 1131 dbSNP
rs763336272 1142 dbSNP
rs866915687 1143 dbSNP
rs991710968 1144 dbSNP
rs1024168868 1145 dbSNP
rs1207734480 1147 dbSNP
rs905448893 1157 dbSNP
rs971711515 1161 dbSNP
rs1456141136 1162 dbSNP
rs562489638 1163 dbSNP
rs1003756901 1166 dbSNP
rs1192413872 1174 dbSNP
rs1035229677 1176 dbSNP
rs554676052 1184 dbSNP
rs1442479400 1185 dbSNP
rs375154212 1190 dbSNP
rs1175923665 1198 dbSNP
rs1004323870 1204 dbSNP
rs1016997637 1215 dbSNP
rs984476497 1217 dbSNP
rs910312099 1219 dbSNP
rs547988192 1226 dbSNP
rs943157011 1228 dbSNP
rs764294269 1229 dbSNP
rs1341098028 1230 dbSNP
rs1317747830 1232 dbSNP
rs762218851 1233 dbSNP
rs576220740 1234 dbSNP
rs1296780106 1236 dbSNP
rs1340107306 1239 dbSNP
rs149655343 1240 dbSNP
rs111732953 1252 dbSNP
rs78729759 1253 dbSNP
rs1365530675 1262 dbSNP
rs1240966709 1263 dbSNP
rs1186123679 1264 dbSNP
rs143715558 1269 dbSNP
rs1218745006 1283 dbSNP
rs1248550178 1286 dbSNP
rs112284568 1289 dbSNP
rs1291804117 1290 dbSNP
rs934512502 1293 dbSNP
rs1230189330 1296 dbSNP
rs989965749 1299 dbSNP
rs1000212812 1302 dbSNP
rs914335699 1307 dbSNP
rs1355822054 1308 dbSNP
rs183969553 1312 dbSNP
rs1226267755 1322 dbSNP
rs1285109370 1335 dbSNP
rs1367514564 1336 dbSNP
rs1490455061 1345 dbSNP
rs1440879147 1346 dbSNP
rs1348462872 1349 dbSNP
rs1325973925 1354 dbSNP
rs894536919 1355 dbSNP
rs564921187 1359 dbSNP
rs533851807 1367 dbSNP
rs1166387039 1372 dbSNP
rs766206825 1378 dbSNP
rs773701572 1378 dbSNP
rs938339030 1379 dbSNP
rs1056671395 1389 dbSNP
rs993339706 1390 dbSNP
rs1222037591 1392 dbSNP
rs1437086912 1394 dbSNP
rs763360143 1399 dbSNP
rs887341531 1402 dbSNP
rs1004354913 1405 dbSNP
rs750573149 1406 dbSNP
rs984403023 1417 dbSNP
rs910247706 1427 dbSNP
rs1277181634 1433 dbSNP
rs147019698 1435 dbSNP
rs1354365871 1464 dbSNP
rs1391203592 1466 dbSNP
rs1406351577 1473 dbSNP
rs766731433 1474 dbSNP
rs975898091 1476 dbSNP
rs996902044 1484 dbSNP
rs1325723127 1487 dbSNP
rs113973990 1491 dbSNP
rs1249402235 1493 dbSNP
rs1180241829 1494 dbSNP
rs754074911 1495 dbSNP
rs1280287563 1500 dbSNP
rs987194536 1505 dbSNP
rs577057731 1512 dbSNP
rs924836489 1532 dbSNP
rs936264803 1543 dbSNP
rs1031618681 1550 dbSNP
rs894513857 1552 dbSNP
rs955919263 1556 dbSNP
rs1359833454 1565 dbSNP
rs11804575 1566 dbSNP
rs1286870510 1568 dbSNP
rs914368021 1569 dbSNP
rs948556092 1570 dbSNP
rs1450722655 1574 dbSNP
rs555578353 1586 dbSNP
rs993308648 1598 dbSNP
rs1176665499 1601 dbSNP
rs778518428 1617 dbSNP
rs938383608 1622 dbSNP
rs1026128951 1627 dbSNP
rs752526681 1635 dbSNP
rs1456074086 1656 dbSNP
rs1177273127 1662 dbSNP
rs1181543409 1663 dbSNP
rs1380251456 1665 dbSNP
rs1473319399 1675 dbSNP
rs566205498 1676 dbSNP
rs1411897307 1678 dbSNP
rs1239314601 1696 dbSNP
rs1329088925 1700 dbSNP
rs1266554036 1703 dbSNP
rs373132233 1707 dbSNP
rs868861774 1714 dbSNP
rs940243313 1722 dbSNP
rs1405053321 1723 dbSNP
rs534890685 1725 dbSNP
rs1038505808 1733 dbSNP
rs558358399 1737 dbSNP
rs1380661662 1746 dbSNP
rs898703239 1760 dbSNP
rs552701146 1762 dbSNP
rs1049868618 1771 dbSNP
rs1161351986 1774 dbSNP
rs777741088 1779 dbSNP
rs1008251458 1794 dbSNP
rs1031641638 1798 dbSNP
rs1422305649 1802 dbSNP
rs1449915545 1806 dbSNP
rs1182524542 1808 dbSNP
rs1282278473 1811 dbSNP
rs578242800 1815 dbSNP
rs544143182 1817 dbSNP
rs187106171 1827 dbSNP
rs977559725 1828 dbSNP
rs866008121 1832 dbSNP
rs1242105797 1834 dbSNP
rs1315476229 1836 dbSNP
rs192659751 1837 dbSNP
rs1238073850 1838 dbSNP
rs1054755831 1847 dbSNP
rs1362459345 1849 dbSNP
rs377756940 1852 dbSNP
rs147613111 1859 dbSNP
rs1236025639 1860 dbSNP
rs928421524 1870 dbSNP
rs1291583861 1874 dbSNP
rs1456521583 1887 dbSNP
rs561616462 1890 dbSNP
rs983087688 1892 dbSNP
rs142221030 1897 dbSNP
rs929406195 1899 dbSNP
rs1191017003 1901 dbSNP
rs1450666238 1906 dbSNP
rs1267042818 1917 dbSNP
rs1047520439 1919 dbSNP
rs540843749 1925 dbSNP
rs1489712335 1935 dbSNP
rs1426074795 1938 dbSNP
rs74081274 1940 dbSNP
rs745463954 1942 dbSNP
rs1339393793 1943 dbSNP
rs1190289750 1948 dbSNP
rs1228976266 1957 dbSNP
rs1402816223 1963 dbSNP
rs1330452387 1986 dbSNP
rs1038623999 1988 dbSNP
rs1006547783 1991 dbSNP
rs533019184 1993 dbSNP
rs1332120619 1997 dbSNP
rs920162318 1999 dbSNP
rs1400409031 2005 dbSNP
rs932862186 2011 dbSNP
rs1170582174 2018 dbSNP
rs1050329041 2022 dbSNP
rs184164911 2030 dbSNP
rs1008275722 2042 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions Hela
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1048187. RNA binding protein: AGO2. Condition:Hela_AGO2_CLIP_control ...

- Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al., 2013, Cell.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' acggucggAGCGGGUCg 5'
                  |||||||| 
Target 5' --------UCGCCCAGg 3'
1 - 9
Article - Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al.
- Cell, 2013
The induction of pluripotency or trans-differentiation of one cell type to another can be accomplished with cell-lineage-specific transcription factors. Here, we report that repression of a single RNA binding polypyrimidine-tract-binding (PTB) protein, which occurs during normal brain development via the action of miR-124, is sufficient to induce trans-differentiation of fibroblasts into functional neurons. Besides its traditional role in regulated splicing, we show that PTB has a previously undocumented function in the regulation of microRNA functions, suppressing or enhancing microRNA targeting by competitive binding on target mRNA or altering local RNA secondary structure. A key event during neuronal induction is the relief of PTB-mediated blockage of microRNA action on multiple components of the REST complex, thereby derepressing a large array of neuronal genes, including miR-124 and multiple neuronal-specific transcription factors, in nonneuronal cells. This converts a negative feedback loop to a positive one to elicit cellular reprogramming to the neuronal lineage.
LinkOut: [PMID: 23313552]
CLIP-seq Support 1 for dataset GSM4903833
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_a
Location of target site NM_001004339 | 3UTR | AUCUCGCUCUGUCGCCCAGGCUGGAGUGCAGUGGCACA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM4903834
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_b
Location of target site NM_001004339 | 3UTR | ACGGAAUCUCGCUCUGUCGCCCAGGCUGGAGUGCAGUGGCACAAUCUCGGCUCACUGCA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM4903836
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_a
Location of target site NM_001004339 | 3UTR | CGGAAUCUCGCUCUGUCGCCCAGGCUGGAGUGCA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM4903837
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_b
Location of target site NM_001004339 | 3UTR | CUCGCUCUGUCGCCCAGGCUGGAGUGCA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 5 for dataset GSM4903838
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_c
Location of target site NM_001004339 | 3UTR | CGCUCUGUCGCCCAGGCUGGAGUGCAGUGGCACA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 6 for dataset GSM1048187
Method / RBP HITS-CLIP / AGO2
Cell line / Condition Hela / Hela_AGO2_CLIP_control
Location of target site ENST00000371532.1 | 3UTR | UCGCCCAGGCUGGAGUGCAGUGGCACAAUCUCGGCU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23313552 / GSE42701
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
108 hsa-miR-4486 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT254654 NF2 neurofibromin 2 2 2
MIRT458684 MRI1 methylthioribose-1-phosphate isomerase 1 2 2
MIRT470845 PLXND1 plexin D1 2 2
MIRT493011 NANOS1 nanos C2HC-type zinc finger 1 2 2
MIRT497264 GRK6 G protein-coupled receptor kinase 6 2 2
MIRT497675 SYNGR1 synaptogyrin 1 2 2
MIRT498219 TLN2 talin 2 2 2
MIRT498310 BCL11B B-cell CLL/lymphoma 11B 2 2
MIRT504048 TOMM5 translocase of outer mitochondrial membrane 5 2 2
MIRT519959 ZCCHC8 zinc finger CCHC-type containing 8 2 2
MIRT531521 NOM1 nucleolar protein with MIF4G domain 1 2 2
MIRT533144 WNT10A Wnt family member 10A 2 2
MIRT533541 TPR translocated promoter region, nuclear basket protein 2 2
MIRT533681 TMEM86A transmembrane protein 86A 2 2
MIRT540321 PIGR polymeric immunoglobulin receptor 2 2
MIRT540719 GUF1 GUF1 homolog, GTPase 2 2
MIRT541566 ZNF43 zinc finger protein 43 2 4
MIRT541787 TBCCD1 TBCC domain containing 1 2 2
MIRT541925 ORC1 origin recognition complex subunit 1 2 4
MIRT542232 FUT9 fucosyltransferase 9 2 2
MIRT542285 POLR3K RNA polymerase III subunit K 2 2
MIRT542299 QTRTD1 queuine tRNA-ribosyltransferase accessory subunit 2 2 4
MIRT542368 PAICS phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase 2 2
MIRT542441 C3 complement C3 2 4
MIRT542475 APOC3 apolipoprotein C3 2 2
MIRT542535 MRPS10 mitochondrial ribosomal protein S10 2 2
MIRT542640 TIMM8A translocase of inner mitochondrial membrane 8A 2 2
MIRT542788 PLEKHA3 pleckstrin homology domain containing A3 2 2
MIRT552104 PPP1R1A protein phosphatase 1 regulatory inhibitor subunit 1A 2 2
MIRT564913 YTHDF1 YTH N6-methyladenosine RNA binding protein 1 2 2
MIRT568606 ACVR2A activin A receptor type 2A 2 2
MIRT607389 LANCL3 LanC like 3 2 2
MIRT607451 ZNF543 zinc finger protein 543 2 2
MIRT610058 MYBPC1 myosin binding protein C, slow type 2 2
MIRT610793 KLK2 kallikrein related peptidase 2 2 2
MIRT617176 GOSR2 golgi SNAP receptor complex member 2 2 2
MIRT620579 WBSCR27 methyltransferase like 27 2 4
MIRT622085 SRPX2 sushi repeat containing protein, X-linked 2 2 2
MIRT622542 PXMP4 peroxisomal membrane protein 4 2 2
MIRT630009 PDE6B phosphodiesterase 6B 2 2
MIRT631813 PTDSS2 phosphatidylserine synthase 2 2 2
MIRT632721 MSANTD4 Myb/SANT DNA binding domain containing 4 with coiled-coils 2 2
MIRT632757 MED28 mediator complex subunit 28 2 2
MIRT634821 ASB6 ankyrin repeat and SOCS box containing 6 2 2
MIRT635255 FBXL20 F-box and leucine rich repeat protein 20 2 2
MIRT637082 SELPLG selectin P ligand 2 2
MIRT637357 ZNF460 zinc finger protein 460 2 2
MIRT637472 DEFB105B defensin beta 105B 2 4
MIRT637504 DEFB105A defensin beta 105A 2 4
MIRT639022 AAK1 AP2 associated kinase 1 2 2
MIRT641012 ANKFY1 ankyrin repeat and FYVE domain containing 1 2 2
MIRT642170 HEBP2 heme binding protein 2 2 2
MIRT648977 ACAD8 acyl-CoA dehydrogenase family member 8 2 2
MIRT650515 UFM1 ubiquitin fold modifier 1 2 2
MIRT650949 INMT indolethylamine N-methyltransferase 2 2
MIRT658354 FAM65B RHO family interacting cell polarization regulator 2 2 2
MIRT660736 ALG14 ALG14, UDP-N-acetylglucosaminyltransferase subunit 2 2
MIRT662191 MEI1 meiotic double-stranded break formation protein 1 2 2
MIRT663045 SLC16A4 solute carrier family 16 member 4 2 2
MIRT664811 IRAK3 interleukin 1 receptor associated kinase 3 2 2
MIRT665161 SF3A1 splicing factor 3a subunit 1 2 4
MIRT665346 YES1 YES proto-oncogene 1, Src family tyrosine kinase 2 2
MIRT666493 SBNO1 strawberry notch homolog 1 2 2
MIRT666545 RNF115 ring finger protein 115 2 2
MIRT669351 BMP3 bone morphogenetic protein 3 2 2
MIRT669904 KIAA0754 KIAA0754 2 4
MIRT670323 CEP57L1 centrosomal protein 57 like 1 2 2
MIRT670430 ELP2 elongator acetyltransferase complex subunit 2 2 2
MIRT670672 KIAA1551 KIAA1551 2 2
MIRT670746 HOOK3 hook microtubule tethering protein 3 2 2
MIRT670998 PTGIS prostaglandin I2 synthase 2 2
MIRT671290 RPL37A ribosomal protein L37a 2 2
MIRT671469 AGPAT6 glycerol-3-phosphate acyltransferase 4 2 2
MIRT671833 STIL STIL, centriolar assembly protein 2 2
MIRT673006 TAF1 TATA-box binding protein associated factor 1 2 2
MIRT675881 CSTF1 cleavage stimulation factor subunit 1 2 2
MIRT678625 OLFML2A olfactomedin like 2A 2 2
MIRT678790 NUPL2 nucleoporin like 2 2 2
MIRT679560 LIN9 lin-9 DREAM MuvB core complex component 2 2
MIRT681032 AAED1 AhpC/TSA antioxidant enzyme domain containing 1 2 2
MIRT682480 LIX1L limb and CNS expressed 1 like 2 2
MIRT682758 MDM2 MDM2 proto-oncogene 2 2
MIRT682810 TMCO1 transmembrane and coiled-coil domains 1 2 2
MIRT682867 C9orf156 tRNA methyltransferase O 2 2
MIRT689233 RPS19 ribosomal protein S19 2 2
MIRT689305 C5AR2 complement component 5a receptor 2 2 2
MIRT689363 ZNF101 zinc finger protein 101 2 2
MIRT689629 NAA30 N(alpha)-acetyltransferase 30, NatC catalytic subunit 2 2
MIRT689654 RBM23 RNA binding motif protein 23 2 2
MIRT690148 PPIL6 peptidylprolyl isomerase like 6 2 2
MIRT691407 DNA2 DNA replication helicase/nuclease 2 2 2
MIRT691847 OSCAR osteoclast associated, immunoglobulin-like receptor 2 2
MIRT692234 ALDH1B1 aldehyde dehydrogenase 1 family member B1 2 2
MIRT694320 NLRP9 NLR family pyrin domain containing 9 2 2
MIRT694365 CHST6 carbohydrate sulfotransferase 6 2 2
MIRT696215 LYZ lysozyme 2 2
MIRT697230 ZYG11A zyg-11 family member A, cell cycle regulator 2 2
MIRT700487 PTPRF protein tyrosine phosphatase, receptor type F 2 2
MIRT700612 PRKCA protein kinase C alpha 2 2
MIRT702456 KIAA1467 family with sequence similarity 234 member B 2 2
MIRT702990 HERPUD2 HERPUD family member 2 2 2
MIRT703998 EIF5A2 eukaryotic translation initiation factor 5A2 2 2
MIRT704701 CHRFAM7A CHRNA7 (exons 5-10) and FAM7A (exons A-E) fusion 2 2
MIRT712481 FSTL3 follistatin like 3 2 2
MIRT712781 ZNF154 zinc finger protein 154 2 2
MIRT714369 HP1BP3 heterochromatin protein 1 binding protein 3 2 2
MIRT722570 C1orf95 stum, mechanosensory transduction mediator homolog 2 2
MIRT722839 C17orf102 chromosome 17 open reading frame 102 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4486 Dabrafenib 44462760 NSC764134 approved resistant High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-4486 Vemurafenib 42611257 NSC761431 approved resistant High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-4486 Doxorubicin 31703 NSC123127 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-miR-4486 Curcumin 969516 NSC32982 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-miR-4486 Paclitaxel 36314 NSC125973 approved resistant High Non-Small Cell Lung Cancer cell line (A549)
hsa-miR-4486 Fulvestrant 17756771 NSC719276 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-miR-4486 Tamoxifen 2733525 NSC180973 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-4486 Cisplatin 5460033 NSC119875 approved sensitive High Gastric Cancer cell line (SGC7901)
hsa-miR-4486 Cisplatin 5460033 NSC119875 approved sensitive Low Gastric Cancer cell line (SGC-7901)
hsa-mir-4486 Dabrafenib 44462760 NSC764134 approved resistant cell line (A375)
hsa-mir-4486 Cisplatin 5460033 NSC119875 approved resistant cell line (BxPC3)
hsa-miR-4486 Temozolomide 5394 NSC362856 approved resistant cell line (U251)
hsa-miR-4486 Doxorubicin 31703 NSC123127 approved resistant cell line (BAS)
hsa-miR-4486 Doxorubicin 31703 NSC123127 approved resistant cell line (HS578T)
hsa-miR-4486 Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)
hsa-miR-4486 Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)
hsa-miR-4486 Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (100 ng/ml)
hsa-miR-4486 Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR4)

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