pre-miRNA Information | |
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pre-miRNA | hsa-mir-921 |
Genomic Coordinates | chr1: 166154743 - 166154798 |
Synonyms | MIRN921, hsa-mir-921, MIR921 |
Description | Homo sapiens miR-921 stem-loop |
Comment | None |
RNA Secondary Structure | ![]() |
Mature miRNA Information | |||||||||||||
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Mature miRNA | hsa-miR-921 | ||||||||||||
Sequence | 2| CUAGUGAGGGACAGAACCAGGAUUC |26 | ||||||||||||
Evidence | Experimental | ||||||||||||
Experiments | Cloned | DRVs in miRNA |
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SNPs in miRNA |
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Putative Targets |
miRNA Expression profile | |
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Human miRNA Tissue Atlas | |
Circulating MicroRNA Expression Profiling |
Gene Information | |||||||||||||||||||||
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Gene Symbol | UBE2B | ||||||||||||||||||||
Synonyms | E2-17kDa, HHR6B, HR6B, RAD6B, UBC2 | ||||||||||||||||||||
Description | ubiquitin conjugating enzyme E2 B | ||||||||||||||||||||
Transcript | NM_003337 | ||||||||||||||||||||
Expression | |||||||||||||||||||||
Putative miRNA Targets on UBE2B | |||||||||||||||||||||
3'UTR of UBE2B (miRNA target sites are highlighted) |
>UBE2B|NM_003337|3'UTR 1 TAGACAACTGGTCTGTTAATCTTTTTCATCATTGTTGTGTATAATTTACCTCTCATTAGAAAGGCTAACAAATTTTAAGT 81 GCCACAGGTTTTAAGGATTCTGCAGAAAAAAAAGAAAAAAGTCCTTCAGTTTAGAACCTACAAAAGCTTGTGTATCTTGA 161 TTAATGTACTTTTTATTGCATGGTGTGAACTAAGTTATTGCTGCATAAATTTGTAATATATCCTGTTTGTATTTTTTTCC 241 AAGTGTATAATGTTGGTGTGGAGTTTTCATGACAGAATATACACATTTTGTAAATCTGTACTTTTTTCAAATATTGAATG 321 CCTTATTTTTGAATTCTTTAGATTTTTAAATTGGAGAAAAGCACTTAAAGTTTTTTATATATGAATATTACATGTAAAGC 401 TGTTAAAATACATAACTTCAGTGCAAGAGACTTTGTCACTTATTTCCTTATGTGTGTAGGAGGGGTTAATAAGTCTCTAG 481 CTCTCCATCTATTGATAGTTTCATTTACAATTTCAAAAGAACATTCTTATATTTTATCAAGGAAGTCTTCAAATTTGATT 561 CTAAATAGCGATTATAATCTCCAACTTTATTTTGAATGTACCTCTATTAGTTTCAATTGAGTAATTCTAGACATAACTGG 641 TTTGACTCTGTCCAACTCTGTATTTAGGCCATTTGTTACAGTTTCTTCATGCATTACTTACTGTTAAAACTGTACCTTTT 721 GCGATTTCACAGTTGGCACTTCTGCCATGAGCAGAGAACTGATGCGACTTGTTTTGCTGCTTGGTAGCACTTTAAAAAAT 801 TTTTTGATTAATGAAGAAAGTAAAACCATAAACATTTGCCAAAAATTCATGCCCCAGTATTAGCAATGAATTAGTTGCAT 881 TGGTTTGAGAAAGGCACATATTGGAGGGAAATCTTGGTGTAACTTAAATATTTGAAAATTACCTTTAATGCAATGCATAT 961 CTGTTTATTCTGGGAAATGTTTTAATGCCAGGGCCTGCTGAGTTGCTTCTTCTTGTGGAGATTTTTTTTTTAATCTCCTG 1041 AGTTGTATAAAAGTTGTACTGCATCTTAGTTTACTGGATAAATTTAAAACACAGTATTGTAGAAAGCTAATACAAAACTA 1121 TCCTATGCCTTCAAATAGTATAGAAAATGGAAAATATACAAGTAAATTCTGTTGAACCACCTGTGTAGTCTCTCTAGTAG 1201 TTAAAACAGCTATTTTAGTAACCCCAAGAGTTTCTTCTCATATCCATAAAATTGGATTACAGTATGGCAATATCTACAGC 1281 TTCTATTCATTATGCAACGTTTAACATTGATTGGATAAATGCTTATAGGCTGGGCCAGGTGGCTCCCACCTGTAGTCCCA 1361 GCACTTTGGGAGGCAAAGGCGGGAGGATCACTTGAGGCCAGGACTTTGAGACCAGCCAGGGCAACATAATAAGACTTTTC 1441 TCTACTTTAAATTTTTTAAAAAATTAGTTGGGCATAGTGGCACTTGCCTGTAGTCTCAGCTACTTAGGAGGCTGAGGTGG 1521 CAGAATAGCTTATGCCTAGGAGGTTGAGGCTGCAGTGAGCTGTGATTATGCCATTGCACTCCAGCCTGGGTGACAGAGCA 1601 ATACCCTGTCTTTAAAAATAAAAGCTATTACTTGGCAAATTCTGAGGTAAGTGTATGATCTTAGGGAACTTTGATACAAA 1681 TGGGAATTCACTCACTGGAATCGTGGCTCCCAAAAAGATGCTTTAATTGTGTGGTGCTTTTATAGTTTAGCTCCA Target sites
Provided by authors
Predicted by miRanda
DRVs
SNPs
DRVs & SNPs
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miRNA-target interactions (Predicted by miRanda) |
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DRVs in gene 3'UTRs | |||||||||||||||||||||
SNPs in gene 3'UTRs |
Experimental Support 1 for Functional miRNA-Target Interaction | |||||||
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miRNA:Target | ---- | ||||||
Validation Method |
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Conditions | Hela | ||||||
Location of target site | 3'UTR | ||||||
Tools used in this research | TargetScan , miRTarCLIP , Piranha | ||||||
Original Description (Extracted from the article) |
...
HITS-CLIP data was present in GSM1048187. RNA binding protein: AGO2. Condition:Hela_AGO2_CLIP_control
... - Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al., 2013, Cell. |
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miRNA-target interactions (Provided by authors) |
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Article |
- Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al. - Cell, 2013
The induction of pluripotency or trans-differentiation of one cell type to another can be accomplished with cell-lineage-specific transcription factors. Here, we report that repression of a single RNA binding polypyrimidine-tract-binding (PTB) protein, which occurs during normal brain development via the action of miR-124, is sufficient to induce trans-differentiation of fibroblasts into functional neurons. Besides its traditional role in regulated splicing, we show that PTB has a previously undocumented function in the regulation of microRNA functions, suppressing or enhancing microRNA targeting by competitive binding on target mRNA or altering local RNA secondary structure. A key event during neuronal induction is the relief of PTB-mediated blockage of microRNA action on multiple components of the REST complex, thereby derepressing a large array of neuronal genes, including miR-124 and multiple neuronal-specific transcription factors, in nonneuronal cells. This converts a negative feedback loop to a positive one to elicit cellular reprogramming to the neuronal lineage.
LinkOut: [PMID: 23313552]
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CLIP-seq Support 1 for dataset GSM1048187 | |
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Method / RBP | HITS-CLIP / AGO2 |
Cell line / Condition | Hela / Hela_AGO2_CLIP_control |
Location of target site | ENST00000265339.2 | 3UTR | CUCACUAUGUUGGCCAGGCUGGUCUC |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 23313552 / GSE42701 |
CLIP-seq Viewer | Link |
MiRNA-Target Expression Profile | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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MiRNA-Target Expression Profile (TCGA) | |||||||
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63 hsa-miR-921 Target Genes:
Functional analysis:
ID![]() |
Target | Description | Validation methods |
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Strong evidence | Less strong evidence | |||||||||||
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MIRT054764 | ANGPTL1 | angiopoietin like 1 | ![]() |
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3 | 1 | |||||
MIRT066171 | PIP4K2C | phosphatidylinositol-5-phosphate 4-kinase type 2 gamma | ![]() |
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2 | 2 | ||||||
MIRT069409 | ZFYVE21 | zinc finger FYVE-type containing 21 | ![]() |
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2 | 8 | ||||||
MIRT102284 | DNAJB9 | DnaJ heat shock protein family (Hsp40) member B9 | ![]() |
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2 | 4 | ||||||
MIRT107595 | DNAJA1 | DnaJ heat shock protein family (Hsp40) member A1 | ![]() |
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2 | 6 | ||||||
MIRT178618 | HIAT1 | major facilitator superfamily domain containing 14A | ![]() |
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2 | 2 | ||||||
MIRT182407 | TIPRL | TOR signaling pathway regulator | ![]() |
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2 | 4 | ||||||
MIRT186552 | ZBTB18 | zinc finger and BTB domain containing 18 | ![]() |
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2 | 2 | ||||||
MIRT273662 | HOXC8 | homeobox C8 | ![]() |
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2 | 2 | ||||||
MIRT283191 | C16ORF52 | chromosome 16 open reading frame 52 | ![]() |
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2 | 2 | ||||||
MIRT284890 | NFAT5 | nuclear factor of activated T-cells 5 | ![]() |
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2 | 2 | ||||||
MIRT347670 | LSM14A | LSM14A, mRNA processing body assembly factor | ![]() |
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2 | 2 | ||||||
MIRT400222 | SLC35F6 | solute carrier family 35 member F6 | ![]() |
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2 | 2 | ||||||
MIRT403517 | ASPH | aspartate beta-hydroxylase | ![]() |
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2 | 2 | ||||||
MIRT442251 | DCTN5 | dynactin subunit 5 | ![]() |
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2 | 2 | ||||||
MIRT443023 | SDR39U1 | short chain dehydrogenase/reductase family 39U member 1 | ![]() |
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2 | 2 | ||||||
MIRT443097 | RNF20 | ring finger protein 20 | ![]() |
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2 | 2 | ||||||
MIRT444560 | TRA2B | transformer 2 beta homolog | ![]() |
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2 | 2 | ||||||
MIRT445696 | PRKG1 | protein kinase, cGMP-dependent, type I | ![]() |
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2 | 2 | ||||||
MIRT454084 | TMEM209 | transmembrane protein 209 | ![]() |
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2 | 2 | ||||||
MIRT455463 | LYPLA2 | lysophospholipase II | ![]() |
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2 | 2 | ||||||
MIRT456653 | TIFA | TRAF interacting protein with forkhead associated domain | ![]() |
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2 | 2 | ||||||
MIRT458147 | LYRM4 | LYR motif containing 4 | ![]() |
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2 | 6 | ||||||
MIRT467073 | SRRD | SRR1 domain containing | ![]() |
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2 | 4 | ||||||
MIRT467245 | SPPL2A | signal peptide peptidase like 2A | ![]() |
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2 | 2 | ||||||
MIRT468246 | SFXN4 | sideroflexin 4 | ![]() |
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2 | 2 | ||||||
MIRT471589 | PAQR5 | progestin and adipoQ receptor family member 5 | ![]() |
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2 | 19 | ||||||
MIRT476639 | G2E3 | G2/M-phase specific E3 ubiquitin protein ligase | ![]() |
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2 | 2 | ||||||
MIRT482433 | ADM | adrenomedullin | ![]() |
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2 | 10 | ||||||
MIRT486848 | PERP | PERP, TP53 apoptosis effector | ![]() |
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2 | 6 | ||||||
MIRT489656 | SHMT1 | serine hydroxymethyltransferase 1 | ![]() |
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2 | 2 | ||||||
MIRT493441 | KANSL1 | KAT8 regulatory NSL complex subunit 1 | ![]() |
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2 | 6 | ||||||
MIRT493841 | FOXN3 | forkhead box N3 | ![]() |
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2 | 4 | ||||||
MIRT501378 | RBFOX2 | RNA binding protein, fox-1 homolog 2 | ![]() |
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2 | 10 | ||||||
MIRT509679 | ATAD5 | ATPase family, AAA domain containing 5 | ![]() |
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2 | 4 | ||||||
MIRT510280 | MED28 | mediator complex subunit 28 | ![]() |
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2 | 2 | ||||||
MIRT512221 | ATXN3 | ataxin 3 | ![]() |
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2 | 6 | ||||||
MIRT514030 | BNIP2 | BCL2 interacting protein 2 | ![]() |
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2 | 2 | ||||||
MIRT521375 | RDX | radixin | ![]() |
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2 | 4 | ||||||
MIRT521444 | RAD51 | RAD51 recombinase | ![]() |
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2 | 2 | ||||||
MIRT526055 | CBR1 | carbonyl reductase 1 | ![]() |
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2 | 2 | ||||||
MIRT528658 | FUNDC2 | FUN14 domain containing 2 | ![]() |
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2 | 2 | ||||||
MIRT529975 | TNFAIP8L1 | TNF alpha induced protein 8 like 1 | ![]() |
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2 | 2 | ||||||
MIRT544098 | IPMK | inositol polyphosphate multikinase | ![]() |
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2 | 2 | ||||||
MIRT545579 | SNRPA1 | small nuclear ribonucleoprotein polypeptide A' | ![]() |
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2 | 2 | ||||||
MIRT547424 | MED4 | mediator complex subunit 4 | ![]() |
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2 | 2 | ||||||
MIRT548955 | CD2AP | CD2 associated protein | ![]() |
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2 | 2 | ||||||
MIRT549537 | NDUFA6 | NADH:ubiquinone oxidoreductase subunit A6 | ![]() |
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2 | 4 | ||||||
MIRT552550 | ZFP36L2 | ZFP36 ring finger protein like 2 | ![]() |
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2 | 4 | ||||||
MIRT554640 | ROBO1 | roundabout guidance receptor 1 | ![]() |
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2 | 2 | ||||||
MIRT564904 | YTHDF1 | YTH N6-methyladenosine RNA binding protein 1 | ![]() |
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2 | 2 | ||||||
MIRT565578 | SLC6A8 | solute carrier family 6 member 8 | ![]() |
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2 | 2 | ||||||
MIRT568312 | BAG4 | BCL2 associated athanogene 4 | ![]() |
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2 | 2 | ||||||
MIRT617891 | PTCHD3 | patched domain containing 3 | ![]() |
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2 | 2 | ||||||
MIRT621892 | TAF13 | TATA-box binding protein associated factor 13 | ![]() |
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2 | 2 | ||||||
MIRT642850 | RNF135 | ring finger protein 135 | ![]() |
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2 | 2 | ||||||
MIRT665395 | WEE1 | WEE1 G2 checkpoint kinase | ![]() |
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2 | 2 | ||||||
MIRT697879 | UBE2B | ubiquitin conjugating enzyme E2 B | ![]() |
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2 | 2 | ||||||
MIRT698492 | THOC2 | THO complex 2 | ![]() |
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2 | 2 | ||||||
MIRT701227 | OCRL | OCRL, inositol polyphosphate-5-phosphatase | ![]() |
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2 | 2 | ||||||
MIRT701872 | MPLKIP | M-phase specific PLK1 interacting protein | ![]() |
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2 | 2 | ||||||
MIRT707045 | TRPV2 | transient receptor potential cation channel subfamily V member 2 | ![]() |
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2 | 2 | ||||||
MIRT715216 | NPVF | neuropeptide VF precursor | ![]() |
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2 | 2 |
miRNA-Drug Associations | |||||||||||||||||||||||||||
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miRNA-Drug Resistance Associations | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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