pre-miRNA Information | |
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pre-miRNA | hsa-mir-6819 |
Genomic Coordinates | chr22: 36286847 - 36286907 |
Description | Homo sapiens miR-6819 stem-loop |
Comment | None |
RNA Secondary Structure | ![]() |
Mature miRNA Information | ||||||||||||||||||||||||||||
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Mature miRNA | hsa-miR-6819-3p | |||||||||||||||||||||||||||
Sequence | 41| AAGCCUCUGUCCCCACCCCAG |61 | |||||||||||||||||||||||||||
Evidence | Experimental | |||||||||||||||||||||||||||
Experiments | Meta-analysis | |||||||||||||||||||||||||||
SNPs in miRNA |
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Putative Targets |
Gene Information | |||||||||||||||||||||
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Gene Symbol | TSPAN6 | ||||||||||||||||||||
Synonyms | T245, TM4SF6, TSPAN-6 | ||||||||||||||||||||
Description | tetraspanin 6 | ||||||||||||||||||||
Transcript | NM_003270 | ||||||||||||||||||||
Expression | |||||||||||||||||||||
Putative miRNA Targets on TSPAN6 | |||||||||||||||||||||
3'UTR of TSPAN6 (miRNA target sites are highlighted) |
>TSPAN6|NM_003270|3'UTR 1 CCCAATGTATCTGTGGGCCTATTCCTCTCTACCTTTAAGGACATTTAGGGTCCCCCCTGTGAATTAGAAAGTTGCTTGGC 81 TGGAGAACTGACAACACTACTTACTGATAGACCAAAAAACTACACCAGTAGGTTGATTCAATCAAGATGTATGTAGACCT 161 AAAACTACACCAATAGGCTGATTCAATCAAGATCCGTGCTCGCAGTGGGCTGATTCAATCAAGATGTATGTTTGCTATGT 241 TCTAAGTCCACCTTCTATCCCATTCATGTTAGATCGTTGAAACCCTGTATCCCTCTGAAACACTGGAAGAGCTAGTAAAT 321 TGTAAATGAAGTAATACTGTGTTCCTCTTGACTGTTATTTTTCTTAGTAGGGGGCCTTTGGAAGGCACTGTGAATTTGCT 401 ATTTTGATGTAGTGTTACAAGATGGAAAATTGATTCCTCTGACTTTGCTATTGATGTAGTGTGATAGAAAATTCACCCCT 481 CTGAACTGGCTCCTTCCCAGTCAAGGTTATCTGGTTTGATTGTATAATTTGCACCAAGAAGTTAAAATGTTTTATGACTC 561 TCTGTTCTGCTGACAGGCAGAGAGTCACATTGTGTAATTTAATTTCAGTCAGTCAATAGATGGCATCCCTCATCAGGGTT 641 GCCAGATGGTGATAACAGTGTAAGGCCTTGGGTCTAAGGCATCCACGACTGGAAGGGACTACTGATGTTCTGTGATACAT 721 CAGGTTTCAGCACACAACTTACATTTCTTTGCCTCCAAATTGAGGCATTTATTATGATGTTCATACTTTCCCTCTTGTTT 801 GAAAGTTTCTAATTATTAAATGGTGTCGGAATTGTTGTATTTTCCTTAGGAATTCAGTGGAACTTATCTTCATTAAATTT 881 AGCTGGTACCAGGTTGATATGACTTGTCAATATTATGGTCAACTTTAAGTCTTAGTTTTCGTTTGTGCCTTTGATTAATA 961 AGTATAACTCTTATACAATAAATACTGCTTTCCTCTAAAAAGATCGTGTTTAAATTAACTTGTAGAAAATCTGCTGGAAT 1041 GGTTGTTGTTTTCCACTGAGAAAGCTAAGCCCTACATTTCTATTCAGAGTACTGTTTTTAGATGTGAAATATAAGCCTGC 1121 GGCCTTAACTCTGTATTAAAAAAAATGTTTTTGTTTAAAAAAAACTGTTCCCATAGGTGCAGCAAACCACCATGGCACAT 1201 GTATACCTATGTAACAAACCTGCACATTCTGCACATGTATCCCAGAACTTAATGTAAACAAAAAAATCTTAAAGTGCAAA 1281 TATTAAAAAAAACTGTTCTCTGTGAAAAAAATTATATTCCATGTTATAAAGTAGCATATGACTAGTGTTCTCCTAGAGAT 1361 CAGACTTTTTTGATTGTATAGTTTGCATTAAAAAGTTGTACAGGGAGGGATGTAACCTGTATCTTCAGGATAATAGGGAA 1441 ATTAATAAGGAAAATAATAATTACTAAAATTTGAGTTGAAGTCAGGGAATTATTTCTTTGGTTTTGAGTCTCTTTATACA 1521 TCCATTAGTAGAACCTGTCTAGTCTGATTGCCACAGTCCTTGAATTGATGGTAAGGGGGAGTCAGTTACAGTTAGAAAAA 1601 AACCTGGGCAAAAACTACTAGTTAAATGATCATGAATTTTGAGTATGTGTTTTAAAATGCTTGGAGTTATTGCAGAAAAA 1681 TGATATTCTCCATTAGAACATTTGATGTGTGACTTTTGACATAGGATAAGGTGATAAGAAAATTAAGTTGAAAAATAGTG 1761 ACTCAAGTACAGCAAATCAGATTTTTGGCTACTGAGATTAAAGAAGCAAATATTTAAAGGATTATCAGCAATTTTCAAAT 1841 ACATATTTTTCACTGCAGTGGTTTTGAAGAATGTTTTAAGGTTATATTTAGAGTTTTTAAAAAAGTTTTCCCTCAGCCAG 1921 CCATGGTGGCTCACATCTGTAATCCCAGCACTTTGAGAGGCTGAGGCGGGCGGATCACCTGAGGTCAGGAGTTCTAGACC 2001 AGCCTGGCCAACATGGTAAAACACCGTCTCTAATAAAAATGCAAAAATTAGCTGGGTGTGGTGGCAAGCACCTGTAATCC 2081 CAGCTACTTGGGAGACTGAGGCAGGAGAATCACTTGAATCCAGGAGTCAGAGGTTGCAGTGAGCCGAGATCACACCACTG 2161 CACTCCAGCCTGGGCGATAAGAGTGAACCTGCATCTCAGAAAAAAAAAAAAAGTTTTCCCTCATTATTAAAAAGGAAAAA 2241 TTATAGAAAATTAAAATATAGAATGTAGAAAGAGGAAAAACACCACACATCACTCGTCAGGTGGATTGGTTTGTTTATTT 2321 TTAAGATGGGTTTATTTTGGATAGCCAGTTAGAAAACGCCCTTATAGCTGATGTGTGCTTGTGCATACTGAATTGTATAC 2401 TTAATTCTGAAAGTAATGAGGAAACATTTCACCTAATGATAACTGGTACAAAGGAAAGTTCACGTGTCTTTAATAGTTTG 2481 CTAATTAGACTAGCTGGTTAGAAAGAGGGATCACTAGATTGGAGAGAGAGATCCAGTTTCCACTGGAGGCAGTAGGTCTG 2561 CTCATTTCCATGGTGACAATCCTAATGGCAGAGGGAGTGAGTTTCCCTTAGTGGCACAGGCTGGGGGTTTTGAGCTTTTA 2641 AGTTTTGTTTTATAGAAATCTGGAGAATTTTACATTTTACTTCACTATATATCTATGTTTAAAATAATTCATTTTTGATG 2721 TCCCAAAATTGATGTGGGTTGCCTTATTTCCAGGCACCAGGTTGCTCACTGCAAGGTGACATTTTGAGAAGCAGAAATCT 2801 CTAGGTATATCTTAAGTGTGAAAAGCTTGTTAGATTTCCATGGCCTATTCCAGGTGGGTTGTTGGGTTTATGTTGTAAGC 2881 ATCAAACTTTTGTGGAAATAAATACCTAATACAAGGTAAAAAAAAAAAAAAA Target sites
Provided by authors
Predicted by miRanda
DRVs
SNPs
DRVs & SNPs
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miRNA-target interactions (Predicted by miRanda) |
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SNPs in gene 3'UTRs |
Experimental Support 1 for Functional miRNA-Target Interaction | |||||||
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miRNA:Target | ---- | ||||||
Validation Method |
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Conditions | Hela | ||||||
Location of target site | 3'UTR | ||||||
Tools used in this research | TargetScan , miRTarCLIP , Piranha | ||||||
Original Description (Extracted from the article) |
...
HITS-CLIP data was present in GSM1048187. RNA binding protein: AGO2. Condition:Hela_AGO2_CLIP_control
... - Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al., 2013, Cell. |
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miRNA-target interactions (Provided by authors) |
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Article |
- Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al. - Cell, 2013
The induction of pluripotency or trans-differentiation of one cell type to another can be accomplished with cell-lineage-specific transcription factors. Here, we report that repression of a single RNA binding polypyrimidine-tract-binding (PTB) protein, which occurs during normal brain development via the action of miR-124, is sufficient to induce trans-differentiation of fibroblasts into functional neurons. Besides its traditional role in regulated splicing, we show that PTB has a previously undocumented function in the regulation of microRNA functions, suppressing or enhancing microRNA targeting by competitive binding on target mRNA or altering local RNA secondary structure. A key event during neuronal induction is the relief of PTB-mediated blockage of microRNA action on multiple components of the REST complex, thereby derepressing a large array of neuronal genes, including miR-124 and multiple neuronal-specific transcription factors, in nonneuronal cells. This converts a negative feedback loop to a positive one to elicit cellular reprogramming to the neuronal lineage.
LinkOut: [PMID: 23313552]
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CLIP-seq Support 1 for dataset GSM1048187 | |
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Method / RBP | HITS-CLIP / AGO2 |
Cell line / Condition | Hela / Hela_AGO2_CLIP_control |
Location of target site | ENST00000373020.4 | 3UTR | CAGCACUUUGAGAGGCUGAGGCG |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 23313552 / GSE42701 |
CLIP-seq Viewer | Link |
MiRNA-Target Expression Profile | |||||||
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MiRNA-Target Expression Profile (TCGA) | |||||||
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108 hsa-miR-6819-3p Target Genes:
Functional analysis:
ID![]() |
Target | Description | Validation methods |
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Strong evidence | Less strong evidence | |||||||||||
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MIRT358318 | PANK3 | pantothenate kinase 3 | ![]() |
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2 | 2 | ||||||
MIRT454719 | UBQLNL | ubiquilin like | ![]() |
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2 | 2 | ||||||
MIRT471362 | PEG10 | paternally expressed 10 | ![]() |
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2 | 2 | ||||||
MIRT478101 | DLG5 | discs large MAGUK scaffold protein 5 | ![]() |
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2 | 4 | ||||||
MIRT495554 | GOLGA6L4 | golgin A6 family-like 4 | ![]() |
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2 | 2 | ||||||
MIRT495587 | GOLGA6L10 | golgin A6 family-like 10 | ![]() |
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2 | 2 | ||||||
MIRT508315 | RPL18 | ribosomal protein L18 | ![]() |
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2 | 4 | ||||||
MIRT529183 | ADAM33 | ADAM metallopeptidase domain 33 | ![]() |
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2 | 2 | ||||||
MIRT532035 | FHDC1 | FH2 domain containing 1 | ![]() |
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2 | 2 | ||||||
MIRT545131 | ANXA5 | annexin A5 | ![]() |
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2 | 2 | ||||||
MIRT567288 | HNRNPL | heterogeneous nuclear ribonucleoprotein L | ![]() |
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2 | 2 | ||||||
MIRT568094 | CEBPG | CCAAT/enhancer binding protein gamma | ![]() |
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2 | 2 | ||||||
MIRT573291 | DLX4 | distal-less homeobox 4 | ![]() |
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2 | 2 | ||||||
MIRT575169 | Fam120c | family with sequence similarity 120, member C | ![]() |
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2 | 2 | ||||||
MIRT609495 | DNASE1L3 | deoxyribonuclease 1 like 3 | ![]() |
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2 | 2 | ||||||
MIRT611264 | EHD3 | EH domain containing 3 | ![]() |
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2 | 2 | ||||||
MIRT613580 | POC5 | POC5 centriolar protein | ![]() |
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2 | 2 | ||||||
MIRT616520 | C9orf170 | chromosome 9 open reading frame 170 | ![]() |
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2 | 2 | ||||||
MIRT617098 | ZNF667 | zinc finger protein 667 | ![]() |
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2 | 2 | ||||||
MIRT618268 | DDX51 | DEAD-box helicase 51 | ![]() |
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2 | 2 | ||||||
MIRT618294 | ZNF682 | zinc finger protein 682 | ![]() |
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2 | 2 | ||||||
MIRT618617 | SHOX | short stature homeobox | ![]() |
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2 | 2 | ||||||
MIRT619741 | SRFBP1 | serum response factor binding protein 1 | ![]() |
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2 | 2 | ||||||
MIRT619784 | NRIP2 | nuclear receptor interacting protein 2 | ![]() |
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2 | 2 | ||||||
MIRT621119 | SP110 | SP110 nuclear body protein | ![]() |
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2 | 2 | ||||||
MIRT622530 | RAD51 | RAD51 recombinase | ![]() |
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2 | 2 | ||||||
MIRT623088 | NME6 | NME/NM23 nucleoside diphosphate kinase 6 | ![]() |
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2 | 2 | ||||||
MIRT623938 | FKBP14 | FK506 binding protein 14 | ![]() |
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2 | 2 | ||||||
MIRT624389 | CD84 | CD84 molecule | ![]() |
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2 | 2 | ||||||
MIRT624860 | ABI2 | abl interactor 2 | ![]() |
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2 | 2 | ||||||
MIRT628752 | TRPV2 | transient receptor potential cation channel subfamily V member 2 | ![]() |
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2 | 2 | ||||||
MIRT632243 | VTA1 | vesicle trafficking 1 | ![]() |
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2 | 2 | ||||||
MIRT632987 | E2F2 | E2F transcription factor 2 | ![]() |
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2 | 2 | ||||||
MIRT633695 | RBM43 | RNA binding motif protein 43 | ![]() |
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2 | 2 | ||||||
MIRT633766 | CENPBD1 | CENPB DNA-binding domain containing 1 | ![]() |
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2 | 2 | ||||||
MIRT633808 | ZNF91 | zinc finger protein 91 | ![]() |
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2 | 2 | ||||||
MIRT638914 | CBLN2 | cerebellin 2 precursor | ![]() |
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2 | 2 | ||||||
MIRT641298 | SLAMF1 | signaling lymphocytic activation molecule family member 1 | ![]() |
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2 | 2 | ||||||
MIRT642123 | SRCAP | Snf2 related CREBBP activator protein | ![]() |
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2 | 2 | ||||||
MIRT642179 | HEBP2 | heme binding protein 2 | ![]() |
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2 | 2 | ||||||
MIRT642617 | CDKN3 | cyclin dependent kinase inhibitor 3 | ![]() |
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2 | 2 | ||||||
MIRT643325 | TMEM151B | transmembrane protein 151B | ![]() |
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2 | 2 | ||||||
MIRT644534 | TMEM134 | transmembrane protein 134 | ![]() |
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2 | 2 | ||||||
MIRT645820 | OMA1 | OMA1 zinc metallopeptidase | ![]() |
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2 | 2 | ||||||
MIRT646093 | MGST3 | microsomal glutathione S-transferase 3 | ![]() |
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2 | 2 | ||||||
MIRT646861 | SLC35E4 | solute carrier family 35 member E4 | ![]() |
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2 | 2 | ||||||
MIRT647466 | DZIP1L | DAZ interacting zinc finger protein 1 like | ![]() |
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2 | 2 | ||||||
MIRT647702 | NADSYN1 | NAD synthetase 1 | ![]() |
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2 | 2 | ||||||
MIRT648082 | ZMIZ2 | zinc finger MIZ-type containing 2 | ![]() |
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2 | 2 | ||||||
MIRT648547 | TMEM169 | transmembrane protein 169 | ![]() |
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2 | 2 | ||||||
MIRT648690 | AP1M1 | adaptor related protein complex 1 mu 1 subunit | ![]() |
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2 | 2 | ||||||
MIRT649747 | GNB5 | G protein subunit beta 5 | ![]() |
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2 | 2 | ||||||
MIRT650154 | ZNF426 | zinc finger protein 426 | ![]() |
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2 | 2 | ||||||
MIRT650450 | CPXM2 | carboxypeptidase X, M14 family member 2 | ![]() |
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2 | 2 | ||||||
MIRT650943 | CTNS | cystinosin, lysosomal cystine transporter | ![]() |
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2 | 2 | ||||||
MIRT651544 | WNK1 | WNK lysine deficient protein kinase 1 | ![]() |
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2 | 2 | ||||||
MIRT652304 | TNRC6B | trinucleotide repeat containing 6B | ![]() |
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2 | 2 | ||||||
MIRT652890 | SYVN1 | synoviolin 1 | ![]() |
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2 | 2 | ||||||
MIRT654222 | RNF19B | ring finger protein 19B | ![]() |
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2 | 2 | ||||||
MIRT654676 | PSMB5 | proteasome subunit beta 5 | ![]() |
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2 | 2 | ||||||
MIRT658249 | FAXC | failed axon connections homolog | ![]() |
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2 | 2 | ||||||
MIRT658363 | FAM65B | RHO family interacting cell polarization regulator 2 | ![]() |
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2 | 2 | ||||||
MIRT659622 | CELF1 | CUGBP Elav-like family member 1 | ![]() |
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2 | 2 | ||||||
MIRT660171 | BNIP3L | BCL2 interacting protein 3 like | ![]() |
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2 | 2 | ||||||
MIRT660634 | ANKRD52 | ankyrin repeat domain 52 | ![]() |
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2 | 2 | ||||||
MIRT662428 | TMCO1 | transmembrane and coiled-coil domains 1 | ![]() |
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2 | 2 | ||||||
MIRT662984 | PAK3 | p21 (RAC1) activated kinase 3 | ![]() |
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2 | 2 | ||||||
MIRT663939 | ZNF554 | zinc finger protein 554 | ![]() |
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2 | 2 | ||||||
MIRT666960 | PKHD1 | PKHD1, fibrocystin/polyductin | ![]() |
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2 | 2 | ||||||
MIRT667945 | HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | ![]() |
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2 | 2 | ||||||
MIRT668847 | CYCS | cytochrome c, somatic | ![]() |
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2 | 2 | ||||||
MIRT671792 | RGS17 | regulator of G protein signaling 17 | ![]() |
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2 | 2 | ||||||
MIRT672382 | RPL37 | ribosomal protein L37 | ![]() |
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2 | 2 | ||||||
MIRT673516 | TNFAIP8L1 | TNF alpha induced protein 8 like 1 | ![]() |
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2 | 4 | ||||||
MIRT674716 | FAM73A | mitoguardin 1 | ![]() |
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2 | 2 | ||||||
MIRT676352 | KLF8 | Kruppel like factor 8 | ![]() |
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2 | 2 | ||||||
MIRT677820 | MRPS10 | mitochondrial ribosomal protein S10 | ![]() |
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2 | 2 | ||||||
MIRT678440 | PDE4C | phosphodiesterase 4C | ![]() |
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2 | 2 | ||||||
MIRT678499 | ARHGEF39 | Rho guanine nucleotide exchange factor 39 | ![]() |
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2 | 2 | ||||||
MIRT679243 | LRP10 | LDL receptor related protein 10 | ![]() |
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2 | 2 | ||||||
MIRT693607 | SLC39A1 | solute carrier family 39 member 1 | ![]() |
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2 | 2 | ||||||
MIRT695927 | ZNF174 | zinc finger protein 174 | ![]() |
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2 | 2 | ||||||
MIRT697987 | TSPAN6 | tetraspanin 6 | ![]() |
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2 | 2 | ||||||
MIRT700821 | PHLDA2 | pleckstrin homology like domain family A member 2 | ![]() |
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2 | 2 | ||||||
MIRT701350 | NR4A3 | nuclear receptor subfamily 4 group A member 3 | ![]() |
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2 | 2 | ||||||
MIRT702348 | KLHL7 | kelch like family member 7 | ![]() |
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2 | 2 | ||||||
MIRT703387 | GABPB1 | GA binding protein transcription factor beta subunit 1 | ![]() |
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2 | 2 | ||||||
MIRT703883 | ERBB2IP | erbb2 interacting protein | ![]() |
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2 | 2 | ||||||
MIRT708237 | PPP1R26 | protein phosphatase 1 regulatory subunit 26 | ![]() |
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2 | 2 | ||||||
MIRT708629 | NUDT18 | nudix hydrolase 18 | ![]() |
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2 | 2 | ||||||
MIRT708990 | CABP4 | calcium binding protein 4 | ![]() |
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2 | 2 | ||||||
MIRT709804 | FOXE1 | forkhead box E1 | ![]() |
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2 | 2 | ||||||
MIRT710203 | FLVCR1 | feline leukemia virus subgroup C cellular receptor 1 | ![]() |
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2 | 2 | ||||||
MIRT710248 | VAMP1 | vesicle associated membrane protein 1 | ![]() |
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2 | 2 | ||||||
MIRT710281 | FGF1 | fibroblast growth factor 1 | ![]() |
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2 | 2 | ||||||
MIRT712992 | IRGQ | immunity related GTPase Q | ![]() |
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2 | 2 | ||||||
MIRT713887 | MOB3A | MOB kinase activator 3A | ![]() |
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2 | 2 | ||||||
MIRT715600 | ADAM17 | ADAM metallopeptidase domain 17 | ![]() |
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2 | 2 | ||||||
MIRT715639 | ZBTB8B | zinc finger and BTB domain containing 8B | ![]() |
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2 | 2 | ||||||
MIRT715686 | FRK | fyn related Src family tyrosine kinase | ![]() |
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2 | 2 | ||||||
MIRT717053 | WIZ | widely interspaced zinc finger motifs | ![]() |
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2 | 2 | ||||||
MIRT717611 | DSTYK | dual serine/threonine and tyrosine protein kinase | ![]() |
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2 | 2 | ||||||
MIRT721539 | DKK3 | dickkopf WNT signaling pathway inhibitor 3 | ![]() |
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2 | 2 | ||||||
MIRT722096 | SUSD1 | sushi domain containing 1 | ![]() |
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2 | 2 | ||||||
MIRT722435 | HRNR | hornerin | ![]() |
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2 | 2 | ||||||
MIRT722855 | NEGR1 | neuronal growth regulator 1 | ![]() |
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2 | 2 | ||||||
MIRT724621 | SNAP25 | synaptosome associated protein 25 | ![]() |
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2 | 2 | ||||||
MIRT724777 | PSG4 | pregnancy specific beta-1-glycoprotein 4 | ![]() |
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2 | 2 |
miRNA-Drug Resistance Associations | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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