pre-miRNA Information | |
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pre-miRNA | hsa-mir-4742 |
Genomic Coordinates | chr1: 224398227 - 224398311 |
Description | Homo sapiens miR-4742 stem-loop |
Comment | None |
RNA Secondary Structure | ![]() |
Mature miRNA Information | |||||||||||||||||||||||||
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Mature miRNA | hsa-miR-4742-5p | ||||||||||||||||||||||||
Sequence | 1| UCAGGCAAAGGGAUAUUUACAGA |23 | ||||||||||||||||||||||||
Evidence | Experimental | ||||||||||||||||||||||||
Experiments | Illumina | ||||||||||||||||||||||||
SNPs in miRNA |
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Putative Targets |
Gene Information | |||||||||||||||||||||
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Gene Symbol | TMEM248 | ||||||||||||||||||||
Synonyms | C7orf42 | ||||||||||||||||||||
Description | transmembrane protein 248 | ||||||||||||||||||||
Transcript | NM_017994 | ||||||||||||||||||||
Expression | |||||||||||||||||||||
Putative miRNA Targets on TMEM248 | |||||||||||||||||||||
3'UTR of TMEM248 (miRNA target sites are highlighted) |
>TMEM248|NM_017994|3'UTR 1 TTCCACAGCTCCTTGTTTTTTGAGAGAGACTGAGAGAACCATAATCCTTGCCTGCTGAACCCAGCCTGGGCCTGGATGCT 81 CTGTGAATACATTATCTTGCGATGTTGGGTTATTCCAGCCAAAGACATTTCAAGTGCCTGTAACTGATTTGTACATATTT 161 ATAAAAATCTATTCAGAAATTGGTCCAATAATGCACGTGCTTTGCCCTGGGTACAGCCAGAGCCCTTCAACCCCACCTTG 241 GACTTGAGGACCTACCTGATGGGACGTTTCCACGTGTCTCTAGAGAAGGATTCCTGGATCTAGCTGGTCACGACGATGTT 321 TTCACCAAGGTCACAGGAGCATTGCGTCGCTGATGGGGTTGAAGTTTGGTTTGGTTCTTGTTTCAGCCCAATATGTAGAG 401 AACATTTGAAACAGTCTGCACCTTTGATACGGTATTGCATTTCCAAAGCCACCAATCCATTTTGTGGATTTTATGTGTTT 481 GTGGCTTAATAATCATAGTAACAACAATAATACCTTTTTCTCCATTTTGCTTGCAGGAAACATACCTTAAGTTTTTTTTG 561 TTTTGTTTTTGTTTTTTTGTTTTTTGTTTTCCTTTATGAAGAAAAAATAAAATAGTCACATTTTAATACTACTCTAGTTA 641 GGACAGACTTGTGCTTTTATCCTGACTAAAAAGTTAAATATTTAAGTCACATACATGGTAAAGATCTAAGTTTCATTTTC 721 CACATGGATGACCAGGAACCTGGTCTTGTTGGAGCTGGCATAGGAGGTTCTACTGTCTTGTCGTCCACTCTTGTCCCTCC 801 CTTCTGTTATCAAAGTTAAAGCGCCTCTTCACTCAAAAGGGCTTCAAAATGTAAATGGCTCTAGAGTTAGAGTGACTGTT 881 TGCTCTTCTGCTTTCTGGAATGCAGATGACAGTATGGAAAGAAAGAATAATGATTCTATCTAATAGGAAAGGATTTCTTC 961 TTTCTTTTTTAAAGAGTGGGTGGATTTTCTCCCTTTTGTTTTGCTTTTATTTTCATGCTACTAACATATCTTCAGAAGGA 1041 AATGGCAACTAGTAGATCAGTAAAATTACGAAAACGATGCCTGCAAAATTTGAAGGAATGCAATTCTGATTTGCCATTTA 1121 TCAGGGAAAACTGAAAGCATTTTTCTTATAACTTTTTTTCTTTTTCTTTTTTTTTGGAGGGGGGAGGCAGGGTCTTGCTC 1201 TGTCCCTCAGGCTGGAGCTTAGCTCAGTGCAGCCTCCAACTCCTGGGCTCAAGCAATCCTCCCACTTTAGCCTCCTGAGT 1281 AGCTGGGACTACAGGCGTGTGCCAGCGCGCCTGGCTAATTTTAAAATTTTTTTGTAGAGACAGAGTCTCCCTCTGTTGCC 1361 CAGGCTGGTCTGGAACTCCTAGCTTCAAATGATCCTCTCACCTCGGCCTCCCAAAATCCTGGGATTCCAGGCGTCAGCCA 1441 CTGCTCTCGGCCCTCTTACACCATTTTGTTTGATTGTCTAGTCCCTGTTTCTTTTTCTTTCTAATCCTTATTCATTTAAG 1521 CAAAACCATACATTATCTTTTCCAGTCCTTTCTTGTATTCTTACTGTTTTTTTAAAATAACTTTTTGCCTTAATAGCTCA 1601 TTGTCACTAATAACTTCTGTGTTCTCCCAGGCAGTGTTATAACAGAAGGGCAATGAAAACATTGGACATGACCATGAGTG 1681 CTTCCTTTCCTTAACTCTAGGTTTGTAGTCTGTTTTAAATTAGGATTAGTTCCTGCATTCTGAAATACATTGGCCTAGAA 1761 CATTTTATCCCAGGCATTTTTGAATAGAAAACAGTTGCGTGCTTTTATTGAAGATTGTTAAAATAATCACCATAGTAACT 1841 TGATATGTTAGTATTTTTCTTTTTCCTTTTAGTATGTTTCAAGTGCAGTAATCGTACTTGTCTATCCAGTTTCTATGTAT 1921 GATACGAGTTGCTTACACGATGCATGGCTAACTTGTTAATTTAGTTTTCTCCTTAGAGACTTTGAGACCCTTAAGAGACA 2001 AGATTGAGAAAGAGCCATGTGGCTTGGCTCTAGAAACGTCATTATCATTAGGACCATCAGATTTTAGATTAAGCTGCTAT 2081 TGAATTAATAAAATCCCAATGAAGCAGAGTTATAGGGATAGATTTATAGCTGGCAGAGTGGTATCAAAGGAGAAAAACAG 2161 TGAAAAAGCCAATTTCACTGGTTCGTTCAATCCAGCTTGTTGCTAATATTAGTTACCCTTGTTTTAATGACAGAGAGTGG 2241 CTGGAATCTGTAGCTAGGGGAGGGGCAACACTGTTAGATGTGAGGAAAGGAAGTGCCAAAAATGCCTGGACAGATGGCTT 2321 GTCCCAAGGCCAGGACACACACTTTAAAATCCAACATTCACCTAAGCAAGTAATTCTTAAAGATCTTACAGAAACGCAGA 2401 GTCAATCAGGTTTATAAAGGAAGGCTGAGGGGAGAGAGGAGGCCTGGGGGCCTGGACGAAGAGGCCTAGGACCTGAAGAG 2481 ACTCCAGCGAGTCTCGGGAAGCCCAGGGGACCTGTCACCATCTGGGCACTTCCCAGGCTCAATGCTCAGCCAGAGTTTGC 2561 TGGTGGACCTCAGGATTCGAAGTGTGCAACAGACGGAGTGCGCTTGCTGTTCAGGGCGGCCCCGTGCAGGAGCACCAGCT 2641 CACCCTCAGGCATCTCGGACTGGAGGGCCAGCAGAAGGTCAGCAACTTACTCTTAAAACGATTGTTTCGGATCATATTGA 2721 TCTCTTTCCTTTTTCCTTTTGTCCTTTCACTGTATGACTTGAATCAGTTTTGATTCTATTTGTAAGTGTTTCTTGTCGTG 2801 AGGCACCTGCCATGTCTGTTGCGTTTTCCTCGGCAGCGTGTAGGGCTTCAGCTTCCTGGGTTTTCACCCTTCCTGCAGGC 2881 ACTGTGGGGTCCTGAGGGCCAGTGGGTCCATTTCACCTCTTGCTGCATGATGGTCAGTAGCTGATCTGTTATGGCATTCA 2961 CTTCCAGATTAATTTTCCGTGTTTGAAGTATGTGCATATGTGCTTTACAGAATAAAACATCTGAATTTA Target sites
Provided by authors
Predicted by miRanda
DRVs
SNPs
DRVs & SNPs
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miRNA-target interactions (Predicted by miRanda) |
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DRVs in gene 3'UTRs | |||||||||||||||||||||
SNPs in gene 3'UTRs |
Experimental Support 1 for Functional miRNA-Target Interaction | |||||||
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miRNA:Target | ---- | ||||||
Validation Method |
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Conditions | Hela | ||||||
Location of target site | 3'UTR | ||||||
Tools used in this research | TargetScan , miRTarCLIP , Piranha | ||||||
Original Description (Extracted from the article) |
...
HITS-CLIP data was present in GSM1048187. RNA binding protein: AGO2. Condition:Hela_AGO2_CLIP_control
... - Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al., 2013, Cell. |
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miRNA-target interactions (Provided by authors) |
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Article |
- Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al. - Cell, 2013
The induction of pluripotency or trans-differentiation of one cell type to another can be accomplished with cell-lineage-specific transcription factors. Here, we report that repression of a single RNA binding polypyrimidine-tract-binding (PTB) protein, which occurs during normal brain development via the action of miR-124, is sufficient to induce trans-differentiation of fibroblasts into functional neurons. Besides its traditional role in regulated splicing, we show that PTB has a previously undocumented function in the regulation of microRNA functions, suppressing or enhancing microRNA targeting by competitive binding on target mRNA or altering local RNA secondary structure. A key event during neuronal induction is the relief of PTB-mediated blockage of microRNA action on multiple components of the REST complex, thereby derepressing a large array of neuronal genes, including miR-124 and multiple neuronal-specific transcription factors, in nonneuronal cells. This converts a negative feedback loop to a positive one to elicit cellular reprogramming to the neuronal lineage.
LinkOut: [PMID: 23313552]
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CLIP-seq Support 1 for dataset GSM1048187 | |
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Method / RBP | HITS-CLIP / AGO2 |
Cell line / Condition | Hela / Hela_AGO2_CLIP_control |
Location of target site | ENST00000341567.4 | 3UTR | UAAUCCUUGCCUGCUGAACCCAGCCUGGGCCUGGAUG |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 23313552 / GSE42701 |
CLIP-seq Viewer | Link |
MiRNA-Target Expression Profile | |||||||
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MiRNA-Target Expression Profile (TCGA) | |||||||
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70 hsa-miR-4742-5p Target Genes:
Functional analysis:
ID![]() |
Target | Description | Validation methods |
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Strong evidence | Less strong evidence | |||||||||||
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MIRT065632 | CLIC4 | chloride intracellular channel 4 | ![]() |
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2 | 4 | ||||||
MIRT068170 | TXLNA | taxilin alpha | ![]() |
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2 | 2 | ||||||
MIRT119024 | TSN | translin | ![]() |
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2 | 2 | ||||||
MIRT165212 | GRAMD3 | GRAM domain containing 2B | ![]() |
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2 | 2 | ||||||
MIRT175254 | PSAT1 | phosphoserine aminotransferase 1 | ![]() |
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2 | 4 | ||||||
MIRT213228 | REST | RE1 silencing transcription factor | ![]() |
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2 | 6 | ||||||
MIRT296337 | PARD6B | par-6 family cell polarity regulator beta | ![]() |
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2 | 2 | ||||||
MIRT316776 | FOXC1 | forkhead box C1 | ![]() |
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2 | 2 | ||||||
MIRT453943 | XRCC6 | X-ray repair cross complementing 6 | ![]() |
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2 | 6 | ||||||
MIRT454599 | RPL13A | ribosomal protein L13a | ![]() |
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2 | 2 | ||||||
MIRT458485 | RMI1 | RecQ mediated genome instability 1 | ![]() |
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2 | 6 | ||||||
MIRT458650 | SGPP2 | sphingosine-1-phosphate phosphatase 2 | ![]() |
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2 | 2 | ||||||
MIRT459240 | ADRBK1 | G protein-coupled receptor kinase 2 | ![]() |
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2 | 2 | ||||||
MIRT461008 | SYT7 | synaptotagmin 7 | ![]() |
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2 | 2 | ||||||
MIRT462026 | RIF1 | replication timing regulatory factor 1 | ![]() |
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2 | 2 | ||||||
MIRT462103 | TMEM214 | transmembrane protein 214 | ![]() |
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2 | 2 | ||||||
MIRT463255 | ZIC5 | Zic family member 5 | ![]() |
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2 | 4 | ||||||
MIRT465190 | TRPS1 | transcriptional repressor GATA binding 1 | ![]() |
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2 | 2 | ||||||
MIRT470507 | PPP1R11 | protein phosphatase 1 regulatory inhibitor subunit 11 | ![]() |
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2 | 2 | ||||||
MIRT472356 | TSPAN1 | tetraspanin 1 | ![]() |
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2 | 2 | ||||||
MIRT473260 | MIDN | midnolin | ![]() |
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2 | 2 | ||||||
MIRT477527 | EIF4G2 | eukaryotic translation initiation factor 4 gamma 2 | ![]() |
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2 | 4 | ||||||
MIRT485182 | PTP4A1 | protein tyrosine phosphatase type IVA, member 1 | ![]() |
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2 | 4 | ||||||
MIRT486461 | MDM2 | MDM2 proto-oncogene | ![]() |
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2 | 2 | ||||||
MIRT492760 | PER1 | period circadian clock 1 | ![]() |
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2 | 8 | ||||||
MIRT496703 | TRIM39 | tripartite motif containing 39 | ![]() |
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2 | 2 | ||||||
MIRT497227 | MORC2 | MORC family CW-type zinc finger 2 | ![]() |
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2 | 2 | ||||||
MIRT499582 | INTU | inturned planar cell polarity protein | ![]() |
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2 | 4 | ||||||
MIRT504081 | C9orf40 | chromosome 9 open reading frame 40 | ![]() |
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2 | 6 | ||||||
MIRT505484 | SRSF2 | serine and arginine rich splicing factor 2 | ![]() |
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2 | 2 | ||||||
MIRT513255 | FBXO17 | F-box protein 17 | ![]() |
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2 | 2 | ||||||
MIRT525061 | FRK | fyn related Src family tyrosine kinase | ![]() |
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2 | 2 | ||||||
MIRT528798 | RAB32 | RAB32, member RAS oncogene family | ![]() |
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2 | 2 | ||||||
MIRT534357 | SFT2D2 | SFT2 domain containing 2 | ![]() |
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2 | 2 | ||||||
MIRT538731 | CAPN1 | calpain 1 | ![]() |
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2 | 2 | ||||||
MIRT550792 | WARS2 | tryptophanyl tRNA synthetase 2, mitochondrial | ![]() |
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2 | 2 | ||||||
MIRT553994 | SRPR | SRP receptor alpha subunit | ![]() |
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2 | 4 | ||||||
MIRT568102 | CDKN1B | cyclin dependent kinase inhibitor 1B | ![]() |
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2 | 2 | ||||||
MIRT570107 | SLC18B1 | solute carrier family 18 member B1 | ![]() |
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2 | 2 | ||||||
MIRT570823 | RPL7L1 | ribosomal protein L7 like 1 | ![]() |
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2 | 2 | ||||||
MIRT572004 | HMGB1 | high mobility group box 1 | ![]() |
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2 | 2 | ||||||
MIRT572352 | PCYT2 | phosphate cytidylyltransferase 2, ethanolamine | ![]() |
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2 | 2 | ||||||
MIRT609716 | TMEM132C | transmembrane protein 132C | ![]() |
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2 | 2 | ||||||
MIRT613982 | LRRC40 | leucine rich repeat containing 40 | ![]() |
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2 | 2 | ||||||
MIRT620740 | CCL16 | C-C motif chemokine ligand 16 | ![]() |
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2 | 2 | ||||||
MIRT625074 | C15orf41 | chromosome 15 open reading frame 41 | ![]() |
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2 | 4 | ||||||
MIRT627941 | NNT | nicotinamide nucleotide transhydrogenase | ![]() |
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2 | 2 | ||||||
MIRT629941 | IGSF6 | immunoglobulin superfamily member 6 | ![]() |
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2 | 2 | ||||||
MIRT633396 | FBXW8 | F-box and WD repeat domain containing 8 | ![]() |
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2 | 2 | ||||||
MIRT635846 | ZNF264 | zinc finger protein 264 | ![]() |
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2 | 2 | ||||||
MIRT638086 | ZNF652 | zinc finger protein 652 | ![]() |
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2 | 2 | ||||||
MIRT643996 | TCHP | trichoplein keratin filament binding | ![]() |
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2 | 2 | ||||||
MIRT660020 | C1GALT1 | core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 | ![]() |
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2 | 2 | ||||||
MIRT660161 | BRCC3 | BRCA1/BRCA2-containing complex subunit 3 | ![]() |
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2 | 2 | ||||||
MIRT668887 | CSRP1 | cysteine and glycine rich protein 1 | ![]() |
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2 | 2 | ||||||
MIRT676729 | METTL14 | methyltransferase like 14 | ![]() |
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2 | 2 | ||||||
MIRT677210 | MURC | caveolae associated protein 4 | ![]() |
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2 | 2 | ||||||
MIRT685949 | PTGIS | prostaglandin I2 synthase | ![]() |
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2 | 2 | ||||||
MIRT687816 | ITPRIPL2 | inositol 1,4,5-trisphosphate receptor interacting protein like 2 | ![]() |
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2 | 2 | ||||||
MIRT689900 | SOD2 | superoxide dismutase 2 | ![]() |
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2 | 2 | ||||||
MIRT698214 | TMEM248 | transmembrane protein 248 | ![]() |
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2 | 2 | ||||||
MIRT698279 | TMEM2 | transmembrane protein 2 | ![]() |
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2 | 2 | ||||||
MIRT698758 | STK4 | serine/threonine kinase 4 | ![]() |
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2 | 2 | ||||||
MIRT698789 | STK38 | serine/threonine kinase 38 | ![]() |
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2 | 2 | ||||||
MIRT703152 | GPR137C | G protein-coupled receptor 137C | ![]() |
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2 | 2 | ||||||
MIRT704408 | CTPS1 | CTP synthase 1 | ![]() |
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2 | 2 | ||||||
MIRT705067 | C4orf32 | family with sequence similarity 241 member A | ![]() |
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2 | 2 | ||||||
MIRT710201 | FLVCR1 | feline leukemia virus subgroup C cellular receptor 1 | ![]() |
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2 | 2 | ||||||
MIRT714495 | HSPA4 | heat shock protein family A (Hsp70) member 4 | ![]() |
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2 | 2 | ||||||
MIRT720082 | TNRC6B | trinucleotide repeat containing 6B | ![]() |
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2 | 2 |
miRNA-Drug Resistance Associations | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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