pre-miRNA Information
pre-miRNA hsa-mir-1245a   
Genomic Coordinates chr2: 188978092 - 188978161
Description Homo sapiens miR-1245a stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-1245a
Sequence 45| AAGUGAUCUAAAGGCCUACAU |65
Evidence Experimental
Experiments Illumina
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN31562560 15 COSMIC
COSN26581044 19 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs906938680 2 dbSNP
rs1159117523 3 dbSNP
rs780486044 6 dbSNP
rs771479866 17 dbSNP
rs1002976932 18 dbSNP
rs1428029219 19 dbSNP
Putative Targets

Gene Information
Gene Symbol TM4SF1   
Synonyms H-L6, L6, M3S1, TAAL6
Description transmembrane 4 L six family member 1
Transcript NM_014220   
Expression
Putative miRNA Targets on TM4SF1
3'UTR of TM4SF1
(miRNA target sites are highlighted)
>TM4SF1|NM_014220|3'UTR
   1 AAGAACCAACCCAGGACAGAGCCACAATCTTCCTCTATTTCATTGTAATTTATATATTTCACTTGTATTCATTTGTAAAA
  81 CTTTGTATTAGTGTAACATACTCCCCACAGTCTACTTTTACAAACGCCTGTAAAGACTGGCATCTTCACAGGATGTCAGT
 161 GTTTAAATTTAGTAAACTTCTTTTTTGTTTGTTTATTTGTTTTTGTTTTTTTTTAAGGAATGAGGAAACAAACCACCCTC
 241 TGGGGGTAATTTACAGACTGAGTGACAGTACTCAGTATATCTGAGATAAACTCTATAATGTTTTGGATAAAAATAACATT
 321 CCAATCACTATTGTATATATGTGCATGTATTTTTTAAATTAAAGATGTCTAGTTGCTTTTTATAAGACCAAGAAGGAGAA
 401 AATCCGACAACCTGGAAAGATTTTTGTTTTCACTGCTTGTATGATGTTTCCCATTCATACACCTATAAATCTCTAACAAG
 481 AGGCCCTTTGAACTGCCTTGTGTTCTGTGAGAAACAAATATTTACTTAGAGTGGAAGGACTGATTGAGAATGTTCCAATC
 561 CAAATGAATGCATCACAACTTACAATGCTGCTCATTGTTGTGAGTACTATGAGATTCAAATTTTTCTAACATATGGAAAG
 641 CCTTTTGTCCTCCAAAGATGAGTACTAGGGATCATGTGTTTAAAAAAAGAAAGGCTACGATGACTGGGCAAGAAGAAAGA
 721 TGGGAAACTGAATAAAGCAGTTGATCAGCATCATTGGAACATGGGGACGAGTGACGGCAGGAGGACCACGAGGAAATACC
 801 CTCAAAACTAACTTGTTTACAACAAAATAAAGTATTCACTACCATGTTAAAAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' uacaUCCGGAAAU-CUAGUGAa 5'
              ||||   || ||| ||| 
Target 5' agaaAGGC---TACGATGACTg 3'
688 - 706 118.00 -8.70
2
miRNA  3' uacaUCCGGAAAUCUAGUGaa 5'
              ||  ||  :|||||:  
Target 5' gatgAGTACTAGGGATCATgt 3'
657 - 677 113.00 -8.00
3
miRNA  3' uacaUCCGGAAAUCUAGUgaa 5'
              | ||  || |||||   
Target 5' aataAAGCAGTT-GATCAgca 3'
731 - 750 108.00 -5.62
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN9135599 41 COSMIC
COSN1269644 44 COSMIC
COSN506238 47 COSMIC
COSN30135261 66 COSMIC
COSN30184664 82 COSMIC
COSN25608232 143 COSMIC
COSN28836007 206 COSMIC
COSN9135598 431 COSMIC
COSN16260818 584 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1248519425 2 dbSNP
rs936706901 6 dbSNP
rs759258649 10 dbSNP
rs1190411225 12 dbSNP
rs1463411079 14 dbSNP
rs766846850 16 dbSNP
rs1201302916 21 dbSNP
rs763471297 25 dbSNP
rs773727003 27 dbSNP
rs765733983 29 dbSNP
rs375984652 38 dbSNP
rs762247065 43 dbSNP
rs771107604 46 dbSNP
rs1329485287 50 dbSNP
rs377015972 52 dbSNP
rs1326267828 54 dbSNP
rs776750110 61 dbSNP
rs768657474 62 dbSNP
rs747223745 64 dbSNP
rs772293017 69 dbSNP
rs1433615823 71 dbSNP
rs1390225175 72 dbSNP
rs1170485160 76 dbSNP
rs745593284 78 dbSNP
rs778713998 81 dbSNP
rs1187949478 84 dbSNP
rs1361651840 86 dbSNP
rs1054197336 87 dbSNP
rs183666836 88 dbSNP
rs371004621 91 dbSNP
rs777310511 93 dbSNP
rs1276843649 98 dbSNP
rs755647451 103 dbSNP
rs1197862339 104 dbSNP
rs750370532 107 dbSNP
rs543700705 111 dbSNP
rs1437831226 114 dbSNP
rs1484576174 115 dbSNP
rs1177303094 116 dbSNP
rs752386654 117 dbSNP
rs780935536 120 dbSNP
rs754684084 125 dbSNP
rs750767182 126 dbSNP
rs578123970 128 dbSNP
rs564657621 129 dbSNP
rs558344281 130 dbSNP
rs764217796 132 dbSNP
rs1163748136 134 dbSNP
rs760686407 135 dbSNP
rs1415384245 137 dbSNP
rs1187572142 140 dbSNP
rs775549421 141 dbSNP
rs1338589651 142 dbSNP
rs1408713635 153 dbSNP
rs541310885 172 dbSNP
rs1370410779 178 dbSNP
rs572369756 182 dbSNP
rs1338858846 183 dbSNP
rs546291501 183 dbSNP
rs1229884154 195 dbSNP
rs1252319772 195 dbSNP
rs963341948 196 dbSNP
rs554966736 200 dbSNP
rs1339118714 206 dbSNP
rs1391513064 206 dbSNP
rs535038630 211 dbSNP
rs139388284 215 dbSNP
rs1491470235 215 dbSNP
rs199657937 215 dbSNP
rs1019128616 217 dbSNP
rs1247052732 220 dbSNP
rs576063789 231 dbSNP
rs1200818646 235 dbSNP
rs1253456688 238 dbSNP
rs1014606776 240 dbSNP
rs1193425726 244 dbSNP
rs1372329330 245 dbSNP
rs8479 249 dbSNP
rs781670282 258 dbSNP
rs777815420 260 dbSNP
rs1470345617 263 dbSNP
rs1205821363 265 dbSNP
rs1344367584 275 dbSNP
rs1012401379 277 dbSNP
rs895397239 279 dbSNP
rs1218850638 286 dbSNP
rs892873200 288 dbSNP
rs1296529321 295 dbSNP
rs1326242063 297 dbSNP
rs1217131818 300 dbSNP
rs751202563 302 dbSNP
rs1324816664 307 dbSNP
rs1203571462 318 dbSNP
rs934489565 322 dbSNP
rs1440403379 323 dbSNP
rs539301601 324 dbSNP
rs1205387069 326 dbSNP
rs1001131541 327 dbSNP
rs924407927 330 dbSNP
rs902482610 334 dbSNP
rs1476724377 341 dbSNP
rs570604025 343 dbSNP
rs1201226993 345 dbSNP
rs1045576012 354 dbSNP
rs1432217402 371 dbSNP
rs766006545 372 dbSNP
rs574785395 375 dbSNP
rs1173416699 382 dbSNP
rs1413551950 384 dbSNP
rs1425364579 389 dbSNP
rs944091895 396 dbSNP
rs142920798 398 dbSNP
rs1376039239 404 dbSNP
rs148549909 405 dbSNP
rs749880628 406 dbSNP
rs1360071460 410 dbSNP
rs1398548532 419 dbSNP
rs1305398875 422 dbSNP
rs921798518 426 dbSNP
rs1346515116 427 dbSNP
rs991887089 432 dbSNP
rs534093919 435 dbSNP
rs568331210 436 dbSNP
rs549400045 439 dbSNP
rs1484026782 440 dbSNP
rs1255481935 441 dbSNP
rs144789190 442 dbSNP
rs963345988 451 dbSNP
rs1259786457 455 dbSNP
rs1487141499 457 dbSNP
rs1224238413 470 dbSNP
rs1269398639 472 dbSNP
rs920675015 474 dbSNP
rs1189438010 483 dbSNP
rs14417 487 dbSNP
rs1252517808 496 dbSNP
rs13351 498 dbSNP
rs553942511 505 dbSNP
rs1280944567 508 dbSNP
rs1379763814 511 dbSNP
rs1418151842 518 dbSNP
rs550229777 526 dbSNP
rs1328875812 527 dbSNP
rs1019097384 536 dbSNP
rs1289427015 540 dbSNP
rs1412208529 548 dbSNP
rs1376076306 555 dbSNP
rs970440957 556 dbSNP
rs1307972651 557 dbSNP
rs1350837422 567 dbSNP
rs34063233 582 dbSNP
rs1302781079 583 dbSNP
rs1247772646 585 dbSNP
rs193178086 593 dbSNP
rs535535519 600 dbSNP
rs564356402 602 dbSNP
rs1234539077 608 dbSNP
rs1011953287 610 dbSNP
rs761718495 613 dbSNP
rs149424019 619 dbSNP
rs1001500663 620 dbSNP
rs1185677044 626 dbSNP
rs902795425 629 dbSNP
rs1045949326 630 dbSNP
rs572410242 634 dbSNP
rs1411467073 637 dbSNP
rs1356627361 647 dbSNP
rs1181236523 649 dbSNP
rs1462990263 655 dbSNP
rs949944516 664 dbSNP
rs1374057948 672 dbSNP
rs1454072038 675 dbSNP
rs10905 682 dbSNP
rs894376684 694 dbSNP
rs1042405169 698 dbSNP
rs1226257845 699 dbSNP
rs1274928154 700 dbSNP
rs10532 704 dbSNP
rs779347404 712 dbSNP
rs3203692 714 dbSNP
rs1043288 717 dbSNP
rs1043289 721 dbSNP
rs1256018426 723 dbSNP
rs1456508471 725 dbSNP
rs562006206 729 dbSNP
rs1205566725 737 dbSNP
rs1286391850 739 dbSNP
rs1180314718 743 dbSNP
rs1422146510 748 dbSNP
rs1008272439 762 dbSNP
rs1429442914 768 dbSNP
rs1170623743 769 dbSNP
rs541463715 773 dbSNP
rs187301204 775 dbSNP
rs575985450 776 dbSNP
rs1049810115 777 dbSNP
rs568066403 783 dbSNP
rs1464662280 785 dbSNP
rs921738929 789 dbSNP
rs1271529988 790 dbSNP
rs1269159064 797 dbSNP
rs1217723823 804 dbSNP
rs1230548818 808 dbSNP
rs1325665444 815 dbSNP
rs1333175803 838 dbSNP
rs1204204789 843 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions Hela
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1048187. RNA binding protein: AGO2. Condition:Hela_AGO2_CLIP_control ...

- Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al., 2013, Cell.

Article - Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al.
- Cell, 2013
The induction of pluripotency or trans-differentiation of one cell type to another can be accomplished with cell-lineage-specific transcription factors. Here, we report that repression of a single RNA binding polypyrimidine-tract-binding (PTB) protein, which occurs during normal brain development via the action of miR-124, is sufficient to induce trans-differentiation of fibroblasts into functional neurons. Besides its traditional role in regulated splicing, we show that PTB has a previously undocumented function in the regulation of microRNA functions, suppressing or enhancing microRNA targeting by competitive binding on target mRNA or altering local RNA secondary structure. A key event during neuronal induction is the relief of PTB-mediated blockage of microRNA action on multiple components of the REST complex, thereby derepressing a large array of neuronal genes, including miR-124 and multiple neuronal-specific transcription factors, in nonneuronal cells. This converts a negative feedback loop to a positive one to elicit cellular reprogramming to the neuronal lineage.
LinkOut: [PMID: 23313552]
CLIP-seq Support 1 for dataset GSM1048187
Method / RBP HITS-CLIP / AGO2
Cell line / Condition Hela / Hela_AGO2_CLIP_control
Location of target site ENST00000472441.1 | 3UTR | AGGAAACAAACCACCCUCUGGGGGUAAUUUACAGACUGAGUGACAGUACUCAGUAUAUCUGAGAUAAACUCUAUAAUGUUUUGGAUAAAAAUAACAUUCCAAUCACUAUUGUAUAUAUGUGCAUGUAUUUUUUAAAUUAAAGAUGUCUAGUUGCUUUUUAU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23313552 / GSE42701
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
HNSC -0.438 0.16 -0.536 0.11 7 Click to see details
BRCA -0.752 0.23 -0.500 0.33 3 Click to see details
BLCA 0.581 0.3 0.500 0.33 3 Click to see details
UCEC -0.502 0.33 -0.500 0.33 3 Click to see details
UCEC -0.502 0.33 -0.500 0.33 3 Click to see details
UCEC -0.502 0.33 -0.500 0.33 3 Click to see details
UCEC -0.502 0.33 -0.500 0.33 3 Click to see details
UCEC -0.502 0.33 -0.500 0.33 3 Click to see details
109 hsa-miR-1245a Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT006574 BRCA2 BRCA2, DNA repair associated 2 1
MIRT055432 SHOC2 SHOC2, leucine rich repeat scaffold protein 2 2
MIRT063879 RASSF8 Ras association domain family member 8 2 6
MIRT077025 WIPF2 WAS/WASL interacting protein family member 2 2 2
MIRT095775 GRPEL2 GrpE like 2, mitochondrial 2 10
MIRT099172 MAP3K4 mitogen-activated protein kinase kinase kinase 4 2 2
MIRT175616 OCRL OCRL, inositol polyphosphate-5-phosphatase 2 2
MIRT456518 LYPLAL1 lysophospholipase like 1 2 2
MIRT464457 UGCG UDP-glucose ceramide glucosyltransferase 2 2
MIRT465747 TMPPE transmembrane protein with metallophosphoesterase domain 2 2
MIRT468257 SFXN4 sideroflexin 4 2 2
MIRT469216 RICTOR RPTOR independent companion of MTOR complex 2 2 2
MIRT472045 NPAT nuclear protein, coactivator of histone transcription 2 2
MIRT481795 APEX1 apurinic/apyrimidinic endodeoxyribonuclease 1 2 2
MIRT500154 CREBBP CREB binding protein 2 2
MIRT506514 MSANTD4 Myb/SANT DNA binding domain containing 4 with coiled-coils 2 4
MIRT506915 KBTBD8 kelch repeat and BTB domain containing 8 2 6
MIRT513901 GRB10 growth factor receptor bound protein 10 2 6
MIRT519128 ALDH2 aldehyde dehydrogenase 2 family (mitochondrial) 2 2
MIRT528121 FOXH1 forkhead box H1 2 2
MIRT528942 SFMBT2 Scm like with four mbt domains 2 2 2
MIRT540580 CEP89 centrosomal protein 89 2 2
MIRT545858 ZNF264 zinc finger protein 264 2 4
MIRT547147 PGM3 phosphoglucomutase 3 2 2
MIRT547434 MED4 mediator complex subunit 4 2 2
MIRT554650 ROBO1 roundabout guidance receptor 1 2 2
MIRT558524 CSRNP3 cysteine and serine rich nuclear protein 3 2 2
MIRT559762 ABHD5 abhydrolase domain containing 5 2 2
MIRT560438 GOLGA7B golgin A7 family member B 2 2
MIRT561974 LRRC59 leucine rich repeat containing 59 2 2
MIRT562442 DDIT4 DNA damage inducible transcript 4 2 2
MIRT563489 ZWINT ZW10 interacting kinetochore protein 2 2
MIRT568265 BMP2K BMP2 inducible kinase 2 2
MIRT572522 KIAA0232 KIAA0232 2 2
MIRT612801 LSM14A LSM14A, mRNA processing body assembly factor 2 2
MIRT621533 ZNF507 zinc finger protein 507 2 2
MIRT625205 GSTCD glutathione S-transferase C-terminal domain containing 2 2
MIRT625615 ZNF84 zinc finger protein 84 2 2
MIRT629215 C12orf66 chromosome 12 open reading frame 66 2 2
MIRT629509 AS3MT arsenite methyltransferase 2 2
MIRT629769 STK25 serine/threonine kinase 25 2 2
MIRT630908 GATAD1 GATA zinc finger domain containing 1 2 2
MIRT632508 RAB13 RAB13, member RAS oncogene family 2 2
MIRT636871 ARSE arylsulfatase E (chondrodysplasia punctata 1) 2 2
MIRT637106 CXorf23 BCLAF1 and THRAP3 family member 3 2 2
MIRT637332 FAM9B family with sequence similarity 9 member B 2 2
MIRT637553 CHST6 carbohydrate sulfotransferase 6 2 2
MIRT637639 ZNF431 zinc finger protein 431 2 2
MIRT637836 CACNG8 calcium voltage-gated channel auxiliary subunit gamma 8 2 2
MIRT638326 RNF11 ring finger protein 11 2 2
MIRT638393 RAB11FIP1 RAB11 family interacting protein 1 2 2
MIRT642450 CLUAP1 clusterin associated protein 1 2 2
MIRT642616 APOPT1 apoptogenic 1, mitochondrial 2 2
MIRT643133 FAM71F2 family with sequence similarity 71 member F2 2 2
MIRT644324 NFKBID NFKB inhibitor delta 2 2
MIRT645150 DIS3 DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease 2 2
MIRT645673 ADK adenosine kinase 2 2
MIRT646091 MGST3 microsomal glutathione S-transferase 3 2 2
MIRT646858 SLC35E4 solute carrier family 35 member E4 2 2
MIRT650153 ZNF426 zinc finger protein 426 2 2
MIRT652483 TMEM181 transmembrane protein 181 2 2
MIRT653790 SIRPA signal regulatory protein alpha 2 2
MIRT655526 PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 2 2
MIRT657077 JPH2 junctophilin 2 2 2
MIRT657322 HOOK3 hook microtubule tethering protein 3 2 2
MIRT662036 FUT2 fucosyltransferase 2 2 2
MIRT662322 ADM2 adrenomedullin 2 2 2
MIRT663211 DARS2 aspartyl-tRNA synthetase 2, mitochondrial 2 2
MIRT663559 CCR6 C-C motif chemokine receptor 6 2 2
MIRT663937 ZNF554 zinc finger protein 554 2 2
MIRT664689 EIF2B2 eukaryotic translation initiation factor 2B subunit beta 2 2
MIRT664709 PAICS phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase 2 2
MIRT665291 ZFP14 ZFP14 zinc finger protein 2 2
MIRT665572 TXNL1 thioredoxin like 1 2 2
MIRT667068 PAOX polyamine oxidase 2 2
MIRT667304 MYO5A myosin VA 2 2
MIRT667442 METTL14 methyltransferase like 14 2 2
MIRT668048 GTPBP10 GTP binding protein 10 2 2
MIRT669604 AGO3 argonaute 3, RISC catalytic component 2 2
MIRT671088 ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 2 2
MIRT674361 SLC35E3 solute carrier family 35 member E3 2 2
MIRT674962 ORAI2 ORAI calcium release-activated calcium modulator 2 2 2
MIRT676394 SEC24D SEC24 homolog D, COPII coat complex component 2 2
MIRT676819 AGMAT agmatinase 2 2
MIRT676891 ENSA endosulfine alpha 2 2
MIRT677059 ZNF34 zinc finger protein 34 2 2
MIRT678424 ANKRD36 ankyrin repeat domain 36 2 2
MIRT678735 SRCAP Snf2 related CREBBP activator protein 2 2
MIRT678930 XPOT exportin for tRNA 2 2
MIRT678954 MYADM myeloid associated differentiation marker 2 2
MIRT679228 MAN2A2 mannosidase alpha class 2A member 2 2 2
MIRT679765 TLR6 toll like receptor 6 2 2
MIRT681992 HRH4 histamine receptor H4 2 2
MIRT687405 NSUN4 NOP2/Sun RNA methyltransferase family member 4 2 2
MIRT694570 RBMXL1 RNA binding motif protein, X-linked like 1 2 2
MIRT698449 TM4SF1 transmembrane 4 L six family member 1 2 2
MIRT706406 HAS2 hyaluronan synthase 2 2 2
MIRT706582 ZNF432 zinc finger protein 432 2 2
MIRT706838 VHLL VHL like 2 2
MIRT706909 DVL3 dishevelled segment polarity protein 3 2 2
MIRT707052 TRPV2 transient receptor potential cation channel subfamily V member 2 2 2
MIRT708583 C11orf54 chromosome 11 open reading frame 54 2 2
MIRT708988 CABP4 calcium binding protein 4 2 2
MIRT713041 ADRA2B adrenoceptor alpha 2B 2 2
MIRT713731 SUCO SUN domain containing ossification factor 2 2
MIRT714968 RAB21 RAB21, member RAS oncogene family 2 2
MIRT717485 PDE4DIP phosphodiesterase 4D interacting protein 2 2
MIRT722826 KLK2 kallikrein related peptidase 2 2 2
MIRT723305 MOGAT1 monoacylglycerol O-acyltransferase 1 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-1245a Trametinib 11707110 NSC758246 approved resistant High Melanoma cell line (M14) (500nM)
hsa-miR-1245a Vemurafenib 42611257 NSC761431 approved resistant High Melanoma cell line (M14) (500nM)
hsa-miR-1245a Trametinib 11707110 NSC758246 approved resistant High Melanoma cell line (M14) (1uM)
hsa-miR-1245a Vemurafenib 42611257 NSC761431 approved resistant High Melanoma cell line (M14) (1uM)
hsa-miR-1245a Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-miR-1245a Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)

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