pre-miRNA Information | |
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pre-miRNA | hsa-mir-2909 |
Genomic Coordinates | chr17: 37033745 - 37033813 |
Description | Homo sapiens miR-2909 stem-loop |
Comment | This miRNA was referred to as hmiR-che-1 in . |
RNA Secondary Structure |
Mature miRNA Information | ||||||||||||||||
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Mature miRNA | hsa-miR-2909 | |||||||||||||||
Sequence | 4| GUUAGGGCCAACAUCUCUUGG |24 | |||||||||||||||
Evidence | Experimental | |||||||||||||||
Experiments | QPCR | |||||||||||||||
SNPs in miRNA |
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Putative Targets |
Gene Information | |||||||||||||||||||||
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Gene Symbol | SLC2A1 | ||||||||||||||||||||
Synonyms | CSE, DYT17, DYT18, DYT9, EIG12, GLUT, GLUT-1, GLUT1, GLUT1DS, HTLVR, PED, SDCHCN | ||||||||||||||||||||
Description | solute carrier family 2 member 1 | ||||||||||||||||||||
Transcript | NM_006516 | ||||||||||||||||||||
Expression | |||||||||||||||||||||
Putative miRNA Targets on SLC2A1 | |||||||||||||||||||||
3'UTR of SLC2A1 (miRNA target sites are highlighted) |
>SLC2A1|NM_006516|3'UTR 1 GTCGCCCCAGATCACCAGCCCGGCCTGCTCCCAGCAGCCCTAAGGATCTCTCAGGAGCACAGGCAGCTGGATGAGACTTC 81 CAAACCTGACAGATGTCAGCCGAGCCGGGCCTGGGGCTCCTTTCTCCAGCCAGCAATGATGTCCAGAAGAATATTCAGGA 161 CTTAACGGCTCCAGGATTTTAACAAAAGCAAGACTGTTGCTCAAATCTATTCAGACAAGCAACAGGTTTTATAATTTTTT 241 TATTACTGATTTTGTTATTTTTATATCAGCCTGAGTCTCCTGTGCCCACATCCCAGGCTTCACCCTGAATGGTTCCATGC 321 CTGAGGGTGGAGACTAAGCCCTGTCGAGACACTTGCCTTCTTCACCCAGCTAATCTGTAGGGCTGGACCTATGTCCTAAG401 GACACACTAATCGAACTATGAACTACAAAGCTTCTATCCCAGGAGGTGGCTATGGCCACCCGTTCTGCTGGCCTGGATCT 481 CCCCACTCTAGGGGTCAGGCTCCATTAGGATTTGCCCCTTCCCATCTCTTCCTACCCAACCACTCAAATTAATCTTTCTT 561 TACCTGAGACCAGTTGGGAGCACTGGAGTGCAGGGAGGAGAGGGGAAGGGCCAGTCTGGGCTGCCGGGTTCTAGTCTCCT 641 TTGCACTGAGGGCCACACTATTACCATGAGAAGAGGGCCTGTGGGAGCCTGCAAACTCACTGCTCAAGAAGACATGGAGA 721 CTCCTGCCCTGTTGTGTATAGATGCAAGATATTTATATATATTTTTGGTTGTCAATATTAAATACAGACACTAAGTTATA 801 GTATATCTGGACAAGCCAACTTGTAAATACACCACCTCACTCCTGTTACTTACCTAAACAGATATAAATGGCTGGTTTTT 881 AGAAACATGGTTTTGAAATGCTTGTGGATTGAGGGTAGGAGGTTTGGATGGGAGTGAGACAGAAGTAAGTGGGGTTGCAA 961 CCACTGCAACGGCTTAGACTTCGACTCAGGATCCAGTCCCTTACACGTACCTCTCATCAGTGTCCTCTTGCTCAAAAATC 1041 TGTTTGATCCCTGTTACCCAGAGAATATATACATTCTTTATCTTGACATTCAAGGCATTTCTATCACATATTTGATAGTT 1121 GGTGTTCAAAAAAACACTAGTTTTGTGCCAGCCGTGATGCTCAGGCTTGAAATGCATTATTTTGAATGTGAAGTAAATAC 1201 TGTACCTTTATTGGACAGGCTCAAAGAGGTTATGTGCCTGAAGTCGCACAGTGAATAAGCTAAAACACCTGCTTTTAACA 1281 ATGGTACCATACAACCACTACTCCATTAACTCCACCCACCTCCTGCACCCCTCCCCACACACACAAAATGAACCACGTTC 1361 TTTGTATGGGCCCAATGAGCTGTCAAGCTGCCCTGTGTTCATTTCATTTGGAATTGCCCCCTCTGGTTCCTCTGTATACT 1441 ACTGCTTCATCTCTAAAGACAGCTCATCCTCCTCCTTCACCCCTGAATTTCCAGAGCACTTCATCTGCTCCTTCATCACA 1521 AGTCCAGTTTTCTGCCACTAGTCTGAATTTCATGAGAAGATGCCGATTTGGTTCCTGTGGGTCCTCAGCACTATTCAGTA 1601 CAGTGCTTGATGCACAGCAGGCACTCAGAAAATACTGGAGGAAATAAAACACCAAAGATATTTGTCAAAAAAAAAAAAAA 1681 AAA Target sites
Provided by authors
Predicted by miRanda
DRVs
SNPs
DRVs & SNPs
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miRNA-target interactions (Predicted by miRanda) |
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DRVs in gene 3'UTRs | |||||||||||||||||||||
SNPs in gene 3'UTRs |
Experimental Support 1 for Functional miRNA-Target Interaction | |
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miRNA:Target | ---- |
Validation Method |
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Conditions | Hela |
Location of target site | 3'UTR |
Tools used in this research | TargetScan , miRTarCLIP , Piranha |
Original Description (Extracted from the article) |
...
HITS-CLIP data was present in GSM1048187. RNA binding protein: AGO2. Condition:Hela_AGO2_CLIP_control
... - Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al., 2013, Cell. |
Article |
- Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al. - Cell, 2013
The induction of pluripotency or trans-differentiation of one cell type to another can be accomplished with cell-lineage-specific transcription factors. Here, we report that repression of a single RNA binding polypyrimidine-tract-binding (PTB) protein, which occurs during normal brain development via the action of miR-124, is sufficient to induce trans-differentiation of fibroblasts into functional neurons. Besides its traditional role in regulated splicing, we show that PTB has a previously undocumented function in the regulation of microRNA functions, suppressing or enhancing microRNA targeting by competitive binding on target mRNA or altering local RNA secondary structure. A key event during neuronal induction is the relief of PTB-mediated blockage of microRNA action on multiple components of the REST complex, thereby derepressing a large array of neuronal genes, including miR-124 and multiple neuronal-specific transcription factors, in nonneuronal cells. This converts a negative feedback loop to a positive one to elicit cellular reprogramming to the neuronal lineage.
LinkOut: [PMID: 23313552]
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CLIP-seq Support 1 for dataset GSM1048187 | |
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Method / RBP | HITS-CLIP / AGO2 |
Cell line / Condition | Hela / Hela_AGO2_CLIP_control |
Location of target site | ENST00000426263.3 | 3UTR | AGGAUCUCUCAGGAGCACAGGCAGCUGGAUGAGA |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 23313552 / GSE42701 |
CLIP-seq Viewer | Link |
MiRNA-Target Expression Profile | |||||||
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MiRNA-Target Expression Profile (TCGA) | |||||||
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33 hsa-miR-2909 Target Genes:
Functional analysis:
ID | Target | Description | Validation methods | |||||||||
Strong evidence | Less strong evidence | |||||||||||
MIRT254788 | XRCC6 | X-ray repair cross complementing 6 | 2 | 4 | ||||||||
MIRT464426 | UHMK1 | U2AF homology motif kinase 1 | 2 | 2 | ||||||||
MIRT478185 | DDX6 | DEAD-box helicase 6 | 2 | 6 | ||||||||
MIRT481768 | APEX1 | apurinic/apyrimidinic endodeoxyribonuclease 1 | 2 | 2 | ||||||||
MIRT489915 | RTKN | rhotekin | 2 | 2 | ||||||||
MIRT500566 | VPS4A | vacuolar protein sorting 4 homolog A | 2 | 8 | ||||||||
MIRT510700 | SREK1IP1 | SREK1 interacting protein 1 | 2 | 6 | ||||||||
MIRT513331 | CDK2 | cyclin dependent kinase 2 | 2 | 4 | ||||||||
MIRT524310 | CTC1 | CST telomere replication complex component 1 | 2 | 4 | ||||||||
MIRT533571 | TOMM40L | translocase of outer mitochondrial membrane 40 like | 2 | 2 | ||||||||
MIRT537784 | EIF4E3 | eukaryotic translation initiation factor 4E family member 3 | 2 | 2 | ||||||||
MIRT540489 | ZMAT4 | zinc finger matrin-type 4 | 2 | 8 | ||||||||
MIRT547020 | PPP1CB | protein phosphatase 1 catalytic subunit beta | 2 | 2 | ||||||||
MIRT549561 | C19orf12 | chromosome 19 open reading frame 12 | 2 | 2 | ||||||||
MIRT557346 | HBP1 | HMG-box transcription factor 1 | 2 | 4 | ||||||||
MIRT564692 | ZNF322P1 | zinc finger protein 322 pseudogene 1 | 2 | 2 | ||||||||
MIRT570167 | LIPG | lipase G, endothelial type | 2 | 2 | ||||||||
MIRT621677 | UBE2QL1 | ubiquitin conjugating enzyme E2 Q family like 1 | 2 | 2 | ||||||||
MIRT629121 | APPL1 | adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 | 2 | 4 | ||||||||
MIRT633745 | MCM9 | minichromosome maintenance 9 homologous recombination repair factor | 2 | 2 | ||||||||
MIRT634178 | TXNDC16 | thioredoxin domain containing 16 | 2 | 2 | ||||||||
MIRT646387 | SLC22A6 | solute carrier family 22 member 6 | 2 | 2 | ||||||||
MIRT651181 | ZNF281 | zinc finger protein 281 | 2 | 2 | ||||||||
MIRT651892 | UFD1L | ubiquitin recognition factor in ER associated degradation 1 | 2 | 2 | ||||||||
MIRT675180 | KIF1C | kinesin family member 1C | 2 | 2 | ||||||||
MIRT682670 | CPM | carboxypeptidase M | 2 | 2 | ||||||||
MIRT685990 | NEK4 | NIMA related kinase 4 | 2 | 2 | ||||||||
MIRT698850 | SRSF2 | serine and arginine rich splicing factor 2 | 2 | 2 | ||||||||
MIRT699396 | SLC2A1 | solute carrier family 2 member 1 | 2 | 2 | ||||||||
MIRT723260 | SREK1 | splicing regulatory glutamic acid and lysine rich protein 1 | 2 | 2 | ||||||||
MIRT725320 | NFASC | neurofascin | 2 | 2 | ||||||||
MIRT734596 | CD276 | CD276 molecule | 2 | 0 | ||||||||
MIRT734938 | PTEN | phosphatase and tensin homolog | 2 | 0 |