pre-miRNA Information
pre-miRNA hsa-mir-4524a   
Genomic Coordinates chr17: 69099564 - 69099632
Description Homo sapiens miR-4524a stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4524a-5p
Sequence 6| AUAGCAGCAUGAACCUGUCUCA |27
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1322445998 8 dbSNP
rs1350790266 13 dbSNP
rs1263495678 21 dbSNP
Putative Targets

Gene Information
Gene Symbol SLC16A9   
Synonyms C10orf36, MCT9
Description solute carrier family 16 member 9
Transcript NM_194298   
Expression
Putative miRNA Targets on SLC16A9
3'UTR of SLC16A9
(miRNA target sites are highlighted)
>SLC16A9|NM_194298|3'UTR
   1 AAGAATATTGGAAGACACTATTTTTGCTATTTTATACCATATAGCAACGATATTTTAACAGATTCTCAAGCAAATTTTCT
  81 AGAGTCAAGACTATTTTCTCATAGCAAAATTTCACAATGACTGACTCTGAATGAATTATTTTTTTTTATATATCCTATTT
 161 TTTATGTAGTGTATGCGTAGCCTCTATCTCGTATTTTTTTCTATTTCTCCTCCCCACACCATCAATGGGACTATTCTGTT
 241 TTGCTGTTATTCACTAGTTCTTAACATTGTAAAAAGTTTGACCAGCCTCAGAAGGCTTTCTCTGTGTAAAGAAGTATAAT
 321 TTCTCTGCCGACTCCATTTAATCCACTGCAAGGCACCTAGAGAGACTGCTCCTATTTTAAAAGTGATGCAAGCATCATGA
 401 TAAGATATGTGTGAAGCCCACTAGGAAATAAATCATTCTCTTCTCTATGTTTGACTTGCTAGTAAACAGAAGACTTCAAG
 481 CCAGCCAGGAAATTAAAGTGGCGACTAAAACAGCCTTAAGAATTGCAGTGGAGCAAATTGGTCATTTTTTAAAAAAATAT
 561 ATTTTAACCTACAGTCACCAGTTTTCATTATTCTATTTACCTCACTGAAGTACTCGCATGTTGTTTGGTACCCACTGAGC
 641 AACTGTTTCAGTTCCTAAGGTATTTGCTGAGATGTGGGTGAACTCCAAATGGAGAAGTAGTCACTGTAGACTTTCTTCAT
 721 GGTTGACCACTCCAACCTTGCTCACTTTTGCTTCTTGGCCATCCACTCAGCTGATGTTTCCTGGGAAGTGCTAATTTTAC
 801 CTGTTTCCAAATTGGAAACACATTTCTCAATCATTCCGTTCTGGCAAATGGGAAACATCCATTTGCTTTGGGCACAGTGG
 881 GGATGGGCTGCAAGTTCTTGCATATCCTCCCAGTGAAGCATTTATTTGCTACTATCAGATTTTACCACTATCAAATATAA
 961 TTCAAGGGCAGAATTAAACGTGAGTGTGTGTGTGTGTGTGTGTGTGTGCTATGCATGCTCTAAGTCTGCATGGGATATGG
1041 GAATGGAAAAGGGCAATAAGAAATTAATACCCTTATGCAGTTGCATTTAACCTTAAGAAAAATGTCCTTGGGATAAACTC
1121 CAATGTTTAATACATTGATTTTTTTTCTAAAGAAATGGGTTTTAAACTTTGGTATGCATCAGAATTCCCTATAGATCTTT
1201 TTGAAAATATAGGTACCTGGGTATCACACATAGAACTTTTAATTCTGCTGGTGTAGGCTGTTGCCCAAACATCTATAATT
1281 TTACTGAGCTCTTCAAGTGATTCTGATAACACAGCCTGGATTGAGAATTTTTATAAGATTGGCAATGGAAAAACATTTAT
1361 TCTTTTAAATAATAATTTTTTTAAAACCCAAGAGGTCAGGGGATTTTATAAACCAATAGCCAAGTGTTCTTTAAATAGGA
1441 GGCACCCTTCCCATTGTGCCAAAATCATCTTTTCATTTATTTTGAAATTTGTATGATTATTTTATACTTGTATGTTGCCT
1521 TTCTTCGAAGGCGCCTGAAGCACTTTATAAACACAAATCCTCACAATACCTCTGTGAGGTAGGTAAATAGTACTTTTCTA
1601 TGTAGTAAACCTGGAATATGGAGAATTTCATAACAGTTCATTCTACTTAATAATGCAATAATGGAGCTCCAAGTTGTCTT
1681 GGACTTCTACACCACACTCAGACTTCTGGAAAGTTTTCTGTACCTCATTCTTTAGTCCCTGTCAAGGTTAGTAAATAAAA
1761 TAAGTGACATAAAAAAAAAAAAAACTAAACTACTTGTTGTGTTGAAAGTTCCTTTTTGCCAGTTATGTTCAGGAAACCCA
1841 ATAACCTGAAAAAGTTTGACTTTGATGTGACATCTTCATATTCATCAATGCTGATAATTGTCCAAAGGCATCTTCACTAT
1921 GTCTGCTAAATAACATCCAATGTGGGCGTTATCTGTTGTCTAGGGGATGAATTTTAAGTTACAATAAAATATTTTTCTTT
2001 GTTTTGCAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' acucugucCAAGUACGACGAUa 5'
                  |||: |||||:|| 
Target 5' actattctGTTT-TGCTGTTAt 3'
230 - 250 137.00 -10.60
2
miRNA  3' acUCUGUCCAAG---UAC-GACGAUa 5'
            ||:||  |||   ||| |||||| 
Target 5' aaAGGCATCTTCACTATGTCTGCTAa 3'
1904 - 1929 136.00 -12.40
3
miRNA  3' acucUGUCCAAGUACGACGAUa 5'
              :| ||| :| ||||:|: 
Target 5' ttctGCTGGTGTAGGCTGTTGc 3'
1243 - 1264 126.00 -12.00
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30167747 3 COSMIC
COSN26381654 12 COSMIC
COSN24969913 14 COSMIC
COSN30158230 39 COSMIC
COSN31525095 44 COSMIC
COSN30472343 49 COSMIC
COSN28857493 63 COSMIC
COSN30459559 65 COSMIC
COSN27332920 138 COSMIC
COSN510687 139 COSMIC
COSN30122621 146 COSMIC
COSN1495899 161 COSMIC
COSN31597679 176 COSMIC
COSN15662299 551 COSMIC
COSN1495898 570 COSMIC
COSN27760753 865 COSMIC
COSN20107137 983 COSMIC
COSN25716284 1199 COSMIC
COSN1495897 1558 COSMIC
COSN20107136 1770 COSMIC
COSN27581888 1770 COSMIC
COSN10070602 1877 COSMIC
COSN1495896 1927 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1359651387 1 dbSNP
rs11006654 2 dbSNP
rs762712173 6 dbSNP
rs1423274305 11 dbSNP
rs1415472558 14 dbSNP
rs367565141 18 dbSNP
rs200154786 21 dbSNP
rs764829772 25 dbSNP
rs1008646779 26 dbSNP
rs772926934 26 dbSNP
rs149206471 29 dbSNP
rs1192119992 36 dbSNP
rs567104177 41 dbSNP
rs1264317651 42 dbSNP
rs768638030 45 dbSNP
rs746800862 46 dbSNP
rs374460830 48 dbSNP
rs1218136416 49 dbSNP
rs1345108606 51 dbSNP
rs1254184395 52 dbSNP
rs1350031339 58 dbSNP
rs140147624 65 dbSNP
rs894496781 80 dbSNP
rs1481843971 81 dbSNP
rs1178597784 84 dbSNP
rs1251618143 85 dbSNP
rs1064030 100 dbSNP
rs1432971515 101 dbSNP
rs1197281969 114 dbSNP
rs1397419013 116 dbSNP
rs1055605073 118 dbSNP
rs1011442831 128 dbSNP
rs1204641661 129 dbSNP
rs1168004619 131 dbSNP
rs774780166 137 dbSNP
rs938615073 137 dbSNP
rs892993253 138 dbSNP
rs1046927254 139 dbSNP
rs1373706962 139 dbSNP
rs765726119 141 dbSNP
rs762261070 146 dbSNP
rs1234964315 147 dbSNP
rs929703405 147 dbSNP
rs1475617064 148 dbSNP
rs148583829 148 dbSNP
rs11006653 149 dbSNP
rs1231638288 153 dbSNP
rs1333959281 157 dbSNP
rs1487988128 164 dbSNP
rs973831445 171 dbSNP
rs1045453057 177 dbSNP
rs910892983 180 dbSNP
rs1190850588 184 dbSNP
rs1188514826 190 dbSNP
rs3763747 195 dbSNP
rs1229608213 199 dbSNP
rs1324606852 201 dbSNP
rs1317484419 203 dbSNP
rs1386873503 209 dbSNP
rs1349490140 210 dbSNP
rs1395968925 212 dbSNP
rs1323596286 218 dbSNP
rs1323538117 221 dbSNP
rs915578471 229 dbSNP
rs1417674375 231 dbSNP
rs566435508 244 dbSNP
rs1168834456 248 dbSNP
rs1476559720 249 dbSNP
rs1371849890 251 dbSNP
rs1193055254 262 dbSNP
rs1269632422 267 dbSNP
rs747225131 268 dbSNP
rs955015849 287 dbSNP
rs1454782800 289 dbSNP
rs1055408182 291 dbSNP
rs1215798500 295 dbSNP
rs547720397 300 dbSNP
rs931541246 303 dbSNP
rs920146421 304 dbSNP
rs1320712586 312 dbSNP
rs972914945 313 dbSNP
rs1212104390 323 dbSNP
rs1468202341 326 dbSNP
rs17776046 329 dbSNP
rs79262114 330 dbSNP
rs986894440 334 dbSNP
rs1246726123 342 dbSNP
rs1487163432 347 dbSNP
rs572609249 348 dbSNP
rs745907300 352 dbSNP
rs778888152 356 dbSNP
rs549991047 361 dbSNP
rs1167387042 364 dbSNP
rs756009354 365 dbSNP
rs1233851854 366 dbSNP
rs1461765033 367 dbSNP
rs1319708651 386 dbSNP
rs1343343053 387 dbSNP
rs1011627497 388 dbSNP
rs894442813 398 dbSNP
rs748088957 400 dbSNP
rs1377838828 405 dbSNP
rs1439776524 408 dbSNP
rs1011475409 414 dbSNP
rs531870085 420 dbSNP
rs1228154838 429 dbSNP
rs1003195774 440 dbSNP
rs1330392697 446 dbSNP
rs1031511683 453 dbSNP
rs1217158424 459 dbSNP
rs1236915562 466 dbSNP
rs780949278 474 dbSNP
rs1482319320 492 dbSNP
rs1190233665 494 dbSNP
rs907148010 498 dbSNP
rs999104916 499 dbSNP
rs1472414559 501 dbSNP
rs1394726681 502 dbSNP
rs907030232 503 dbSNP
rs561433808 507 dbSNP
rs1402326205 515 dbSNP
rs1196659341 519 dbSNP
rs371544423 524 dbSNP
rs1412385177 525 dbSNP
rs1167898612 529 dbSNP
rs929795057 537 dbSNP
rs1341835689 540 dbSNP
rs147748697 550 dbSNP
rs1012650183 551 dbSNP
rs1491356077 551 dbSNP
rs869168832 552 dbSNP
rs754834297 556 dbSNP
rs11006652 558 dbSNP
rs1213081668 558 dbSNP
rs1281179789 559 dbSNP
rs1233672931 560 dbSNP
rs1227293544 568 dbSNP
rs930271282 569 dbSNP
rs766105093 570 dbSNP
rs1037252088 575 dbSNP
rs940215061 580 dbSNP
rs1230907983 589 dbSNP
rs986510602 591 dbSNP
rs11006651 593 dbSNP
rs987313164 595 dbSNP
rs923524996 603 dbSNP
rs545726500 614 dbSNP
rs1174925837 615 dbSNP
rs764660049 616 dbSNP
rs1349944474 618 dbSNP
rs762325790 620 dbSNP
rs1021751457 631 dbSNP
rs377234485 632 dbSNP
rs1443367850 634 dbSNP
rs1232931263 636 dbSNP
rs1274684342 643 dbSNP
rs1376938043 654 dbSNP
rs577552083 655 dbSNP
rs990114061 662 dbSNP
rs1369388195 668 dbSNP
rs990193296 679 dbSNP
rs957336224 681 dbSNP
rs1031585338 683 dbSNP
rs777338807 684 dbSNP
rs971661005 688 dbSNP
rs1024129705 690 dbSNP
rs1439547245 693 dbSNP
rs189123936 706 dbSNP
rs1346721883 715 dbSNP
rs894247697 719 dbSNP
rs761166143 729 dbSNP
rs1002900794 736 dbSNP
rs1328601981 738 dbSNP
rs1416001440 742 dbSNP
rs1377813820 745 dbSNP
rs1027366507 747 dbSNP
rs1025524115 750 dbSNP
rs994513228 751 dbSNP
rs1452441500 754 dbSNP
rs1172247468 755 dbSNP
rs537514065 759 dbSNP
rs11006650 761 dbSNP
rs1037726999 766 dbSNP
rs940264630 768 dbSNP
rs144169916 773 dbSNP
rs1398158144 777 dbSNP
rs942412662 783 dbSNP
rs1410223140 785 dbSNP
rs889562063 786 dbSNP
rs1051283745 788 dbSNP
rs1051309858 794 dbSNP
rs1304818982 812 dbSNP
rs933644210 824 dbSNP
rs533739426 829 dbSNP
rs923610859 834 dbSNP
rs772294186 836 dbSNP
rs1227980066 837 dbSNP
rs2893808 838 dbSNP
rs759678370 853 dbSNP
rs1466972122 856 dbSNP
rs914736444 859 dbSNP
rs1253532104 861 dbSNP
rs1464425350 875 dbSNP
rs990309502 876 dbSNP
rs1374327774 886 dbSNP
rs958764937 890 dbSNP
rs551376049 897 dbSNP
rs1034408220 898 dbSNP
rs990188293 904 dbSNP
rs971382257 907 dbSNP
rs1210007916 914 dbSNP
rs1317042287 930 dbSNP
rs1285715021 933 dbSNP
rs1026102646 937 dbSNP
rs994077659 940 dbSNP
rs1221784990 946 dbSNP
rs1327112927 955 dbSNP
rs1447485118 957 dbSNP
rs1291660299 958 dbSNP
rs1337295337 966 dbSNP
rs898444092 968 dbSNP
rs936045191 969 dbSNP
rs1293467283 978 dbSNP
rs141936985 979 dbSNP
rs571528105 980 dbSNP
rs55858178 984 dbSNP
rs1050832436 985 dbSNP
rs1447085502 985 dbSNP
rs933738431 986 dbSNP
rs971353089 986 dbSNP
rs917131067 991 dbSNP
rs774429562 992 dbSNP
rs1476013484 998 dbSNP
rs145974492 999 dbSNP
rs1042482980 1003 dbSNP
rs1411733722 1004 dbSNP
rs1414671988 1006 dbSNP
rs1311189771 1009 dbSNP
rs1386393034 1009 dbSNP
rs1395510280 1009 dbSNP
rs1406217998 1009 dbSNP
rs143114077 1009 dbSNP
rs1452186970 1009 dbSNP
rs878994395 1009 dbSNP
rs758384435 1010 dbSNP
rs991339333 1012 dbSNP
rs1486427994 1013 dbSNP
rs958492087 1017 dbSNP
rs147571220 1020 dbSNP
rs531799063 1025 dbSNP
rs1417697636 1029 dbSNP
rs937474374 1031 dbSNP
rs1364854208 1033 dbSNP
rs1407530741 1035 dbSNP
rs1466012895 1037 dbSNP
rs1165872684 1039 dbSNP
rs867470635 1040 dbSNP
rs1377376908 1048 dbSNP
rs994583877 1056 dbSNP
rs1307662009 1057 dbSNP
rs561372745 1070 dbSNP
rs961727539 1073 dbSNP
rs11006649 1077 dbSNP
rs1486153273 1084 dbSNP
rs1336251123 1103 dbSNP
rs1008949395 1118 dbSNP
rs891381984 1120 dbSNP
rs1349418670 1125 dbSNP
rs1445852745 1127 dbSNP
rs1273461974 1130 dbSNP
rs1250397212 1134 dbSNP
rs1479481180 1137 dbSNP
rs1197891178 1139 dbSNP
rs918582836 1139 dbSNP
rs184347568 1146 dbSNP
rs1006820369 1147 dbSNP
rs1016833107 1147 dbSNP
rs962722084 1147 dbSNP
rs1337455928 1149 dbSNP
rs997007064 1158 dbSNP
rs560773543 1159 dbSNP
rs1169903726 1168 dbSNP
rs1352960569 1170 dbSNP
rs1463760836 1174 dbSNP
rs1299632737 1175 dbSNP
rs1396981314 1180 dbSNP
rs545358507 1182 dbSNP
rs900009940 1187 dbSNP
rs1054493730 1189 dbSNP
rs533704230 1190 dbSNP
rs1363284170 1191 dbSNP
rs1272360565 1195 dbSNP
rs867577822 1197 dbSNP
rs1229182023 1211 dbSNP
rs1252191787 1213 dbSNP
rs924662676 1215 dbSNP
rs1029949786 1218 dbSNP
rs10826340 1219 dbSNP
rs10826339 1228 dbSNP
rs1042039264 1231 dbSNP
rs1010505896 1232 dbSNP
rs893478738 1237 dbSNP
rs1171398209 1240 dbSNP
rs867299052 1249 dbSNP
rs1417488422 1251 dbSNP
rs917180799 1260 dbSNP
rs1460728109 1275 dbSNP
rs573352335 1284 dbSNP
rs991396797 1285 dbSNP
rs1396570585 1288 dbSNP
rs1410184625 1289 dbSNP
rs1428839952 1297 dbSNP
rs1287741888 1299 dbSNP
rs556245685 1303 dbSNP
rs1383498865 1307 dbSNP
rs1295830825 1317 dbSNP
rs1333785621 1319 dbSNP
rs1231808311 1334 dbSNP
rs958566812 1339 dbSNP
rs1046348843 1342 dbSNP
rs181749206 1345 dbSNP
rs1215740436 1347 dbSNP
rs920406589 1348 dbSNP
rs1486884794 1355 dbSNP
rs1187257952 1359 dbSNP
rs778475658 1368 dbSNP
rs1474808898 1374 dbSNP
rs555039780 1375 dbSNP
rs918642311 1382 dbSNP
rs1162470054 1383 dbSNP
rs961832416 1383 dbSNP
rs972825220 1383 dbSNP
rs1158309478 1389 dbSNP
rs962670018 1395 dbSNP
rs149902082 1400 dbSNP
rs1298322328 1402 dbSNP
rs1354404292 1414 dbSNP
rs1008573881 1417 dbSNP
rs1356507363 1419 dbSNP
rs985372350 1432 dbSNP
rs1282769954 1439 dbSNP
rs954520821 1443 dbSNP
rs1029956145 1451 dbSNP
rs1279736120 1453 dbSNP
rs1484791858 1471 dbSNP
rs11006648 1489 dbSNP
rs1029486726 1490 dbSNP
rs900040780 1492 dbSNP
rs998452244 1493 dbSNP
rs1054565710 1494 dbSNP
rs1308403882 1503 dbSNP
rs1020633517 1505 dbSNP
rs1420855983 1507 dbSNP
rs1213298869 1508 dbSNP
rs1374351783 1510 dbSNP
rs1000298269 1518 dbSNP
rs1432406282 1521 dbSNP
rs1314341943 1526 dbSNP
rs903271472 1527 dbSNP
rs893468802 1531 dbSNP
rs533811508 1532 dbSNP
rs1369072525 1533 dbSNP
rs1302679256 1537 dbSNP
rs1345836698 1542 dbSNP
rs1054751598 1546 dbSNP
rs1437503803 1551 dbSNP
rs1203528948 1552 dbSNP
rs11006647 1555 dbSNP
rs906131824 1560 dbSNP
rs1179182017 1562 dbSNP
rs1356013269 1563 dbSNP
rs1168299162 1564 dbSNP
rs1452013840 1566 dbSNP
rs75776621 1567 dbSNP
rs1425410263 1570 dbSNP
rs1409036614 1573 dbSNP
rs950234136 1579 dbSNP
rs1395219685 1590 dbSNP
rs918772606 1593 dbSNP
rs1448095098 1602 dbSNP
rs754369621 1603 dbSNP
rs1369514640 1611 dbSNP
rs1236548704 1614 dbSNP
rs941466337 1615 dbSNP
rs909876908 1618 dbSNP
rs569142264 1630 dbSNP
rs937225942 1631 dbSNP
rs764642705 1635 dbSNP
rs920480616 1636 dbSNP
rs985490034 1646 dbSNP
rs1270538066 1647 dbSNP
rs932568771 1655 dbSNP
rs1199097372 1656 dbSNP
rs973249862 1658 dbSNP
rs1177371829 1664 dbSNP
rs761292780 1666 dbSNP
rs1194912046 1668 dbSNP
rs1246818246 1676 dbSNP
rs753035759 1684 dbSNP
rs76453639 1686 dbSNP
rs966905714 1689 dbSNP
rs77437312 1690 dbSNP
rs1281603364 1692 dbSNP
rs567704290 1710 dbSNP
rs1443779353 1713 dbSNP
rs957810804 1724 dbSNP
rs538545670 1729 dbSNP
rs1392159819 1746 dbSNP
rs1428820073 1749 dbSNP
rs1375341657 1750 dbSNP
rs1296226024 1752 dbSNP
rs1408929717 1753 dbSNP
rs1272127353 1754 dbSNP
rs1375995860 1756 dbSNP
rs1175388292 1760 dbSNP
rs1432347869 1761 dbSNP
rs1376550213 1765 dbSNP
rs1159429130 1766 dbSNP
rs199593303 1768 dbSNP
rs1253181287 1769 dbSNP
rs199691320 1770 dbSNP
rs398046044 1771 dbSNP
rs564712160 1771 dbSNP
rs1445907150 1772 dbSNP
rs1190483444 1777 dbSNP
rs1243460375 1781 dbSNP
rs1477971082 1782 dbSNP
rs540702181 1783 dbSNP
rs1491453376 1784 dbSNP
rs964282493 1784 dbSNP
rs1429870975 1785 dbSNP
rs561226004 1785 dbSNP
rs71467072 1785 dbSNP
rs906211050 1791 dbSNP
rs1414431319 1793 dbSNP
rs11812704 1794 dbSNP
rs1353346129 1796 dbSNP
rs756880594 1801 dbSNP
rs1014512258 1802 dbSNP
rs527817275 1812 dbSNP
rs1000327246 1814 dbSNP
rs1202832002 1819 dbSNP
rs1255460559 1820 dbSNP
rs34560056 1822 dbSNP
rs903341170 1826 dbSNP
rs1476382359 1828 dbSNP
rs1020406991 1831 dbSNP
rs77031038 1833 dbSNP
rs1363693419 1838 dbSNP
rs551965112 1845 dbSNP
rs895842595 1847 dbSNP
rs888557222 1850 dbSNP
rs1055815116 1859 dbSNP
rs1311277992 1867 dbSNP
rs1377576418 1870 dbSNP
rs1397528461 1874 dbSNP
rs1318967855 1881 dbSNP
rs190447959 1883 dbSNP
rs899083023 1886 dbSNP
rs1037616567 1888 dbSNP
rs940575774 1889 dbSNP
rs573055494 1902 dbSNP
rs907684791 1917 dbSNP
rs373279529 1918 dbSNP
rs932617263 1924 dbSNP
rs1355799318 1936 dbSNP
rs1353814770 1939 dbSNP
rs1314710429 1941 dbSNP
rs746949297 1947 dbSNP
rs933078066 1948 dbSNP
rs921662507 1950 dbSNP
rs1484050212 1955 dbSNP
rs977069921 1961 dbSNP
rs1250299400 1963 dbSNP
rs1436515461 1972 dbSNP
rs974383384 1973 dbSNP
rs1381539144 1976 dbSNP
rs957668627 1985 dbSNP
rs945345525 1989 dbSNP
rs913721691 1991 dbSNP
rs563198107 1998 dbSNP
rs1033256788 2000 dbSNP
rs979420471 2001 dbSNP
rs139118508 2006 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions Hela
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1048187. RNA binding protein: AGO2. Condition:Hela_AGO2_CLIP_control ...

- Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al., 2013, Cell.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' acucuguccaaguacGACGAUa 5'
                         |||||| 
Target 5' -----------auguCUGCUAa 3'
1 - 11
Article - Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al.
- Cell, 2013
The induction of pluripotency or trans-differentiation of one cell type to another can be accomplished with cell-lineage-specific transcription factors. Here, we report that repression of a single RNA binding polypyrimidine-tract-binding (PTB) protein, which occurs during normal brain development via the action of miR-124, is sufficient to induce trans-differentiation of fibroblasts into functional neurons. Besides its traditional role in regulated splicing, we show that PTB has a previously undocumented function in the regulation of microRNA functions, suppressing or enhancing microRNA targeting by competitive binding on target mRNA or altering local RNA secondary structure. A key event during neuronal induction is the relief of PTB-mediated blockage of microRNA action on multiple components of the REST complex, thereby derepressing a large array of neuronal genes, including miR-124 and multiple neuronal-specific transcription factors, in nonneuronal cells. This converts a negative feedback loop to a positive one to elicit cellular reprogramming to the neuronal lineage.
LinkOut: [PMID: 23313552]
CLIP-seq Support 1 for dataset GSM1048187
Method / RBP HITS-CLIP / AGO2
Cell line / Condition Hela / Hela_AGO2_CLIP_control
Location of target site ENST00000395348.3 | 3UTR | AUGUCUGCUAAAUAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23313552 / GSE42701
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
180 hsa-miR-4524a-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT055251 CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2 2 2
MIRT055826 PLEKHA1 pleckstrin homology domain containing A1 2 2
MIRT060573 CCND1 cyclin D1 2 2
MIRT061013 C1ORF21 chromosome 1 open reading frame 21 2 6
MIRT064694 CCND2 cyclin D2 2 4
MIRT075268 SNTB2 syntrophin beta 2 2 4
MIRT079668 NAPG NSF attachment protein gamma 2 12
MIRT081651 CCNE1 cyclin E1 2 4
MIRT082996 PNPLA6 patatin like phospholipase domain containing 6 2 2
MIRT083463 RALGAPB Ral GTPase activating protein non-catalytic beta subunit 2 4
MIRT085755 RIF1 replication timing regulatory factor 1 2 2
MIRT086022 UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative) 2 2
MIRT087431 ZNRF3 zinc and ring finger 3 2 2
MIRT088786 SOCS5 suppressor of cytokine signaling 5 2 2
MIRT089221 ACTR2 ARP2 actin related protein 2 homolog 2 2
MIRT093696 PI4K2B phosphatidylinositol 4-kinase type 2 beta 2 6
MIRT095090 SEC24A SEC24 homolog A, COPII coat complex component 2 4
MIRT096249 CANX calnexin 2 2
MIRT100215 PPP1R11 protein phosphatase 1 regulatory inhibitor subunit 11 2 2
MIRT100746 VEGFA vascular endothelial growth factor A 2 12
MIRT100904 CD2AP CD2 associated protein 2 2
MIRT102647 UBN2 ubinuclein 2 2 10
MIRT103882 FOXK1 forkhead box K1 2 2
MIRT104246 DMTF1 cyclin D binding myb like transcription factor 1 2 2
MIRT106310 ZFHX4 zinc finger homeobox 4 2 6
MIRT107696 RECK reversion inducing cysteine rich protein with kazal motifs 2 2
MIRT114943 CHAC1 ChaC glutathione specific gamma-glutamylcyclotransferase 1 2 2
MIRT117671 SCAMP4 secretory carrier membrane protein 4 2 2
MIRT133799 SKI SKI proto-oncogene 2 2
MIRT140167 SPRED1 sprouty related EVH1 domain containing 1 2 2
MIRT142279 DCTN5 dynactin subunit 5 2 8
MIRT143288 N4BP1 NEDD4 binding protein 1 2 2
MIRT165939 CREBRF CREB3 regulatory factor 2 2
MIRT175251 PSAT1 phosphoserine aminotransferase 1 2 6
MIRT186381 PNRC2 proline rich nuclear receptor coactivator 2 2 2
MIRT191470 PPM1A protein phosphatase, Mg2+/Mn2+ dependent 1A 2 2
MIRT196480 TAOK1 TAO kinase 1 2 2
MIRT201470 SNRPB2 small nuclear ribonucleoprotein polypeptide B2 2 8
MIRT204615 HSPE1-MOB4 HSPE1-MOB4 readthrough 2 8
MIRT204646 MOB4 MOB family member 4, phocein 2 8
MIRT204749 BZW1 basic leucine zipper and W2 domains 1 2 12
MIRT206031 NUP50 nucleoporin 50 2 6
MIRT211196 FGF2 fibroblast growth factor 2 2 4
MIRT229353 ZNF449 zinc finger protein 449 2 2
MIRT247138 WEE1 WEE1 G2 checkpoint kinase 2 4
MIRT249461 ZNF691 zinc finger protein 691 2 4
MIRT256314 CDC42SE2 CDC42 small effector 2 2 2
MIRT258419 WIPI2 WD repeat domain, phosphoinositide interacting 2 2 2
MIRT265083 CHEK1 checkpoint kinase 1 2 2
MIRT270561 SETD1B SET domain containing 1B 2 2
MIRT274749 RAB3IP RAB3A interacting protein 2 2
MIRT277515 PPP2R5C protein phosphatase 2 regulatory subunit B'gamma 2 4
MIRT289642 CBX2 chromobox 2 2 2
MIRT301001 MTMR3 myotubularin related protein 3 2 2
MIRT307149 CTDSPL CTD small phosphatase like 2 4
MIRT309021 USP53 ubiquitin specific peptidase 53 2 2
MIRT314100 PIK3R1 phosphoinositide-3-kinase regulatory subunit 1 2 8
MIRT319338 CAPZA2 capping actin protein of muscle Z-line alpha subunit 2 2 2
MIRT320619 ZNRF2 zinc and ring finger 2 2 2
MIRT324285 LURAP1L leucine rich adaptor protein 1 like 2 2
MIRT446498 ASCC1 activating signal cointegrator 1 complex subunit 1 2 2
MIRT448437 TLL1 tolloid like 1 2 2
MIRT461537 ACTR3B ARP3 actin related protein 3 homolog B 2 2
MIRT463162 ZNF367 zinc finger protein 367 2 10
MIRT463493 ZC3H10 zinc finger CCCH-type containing 10 2 2
MIRT465154 TSC22D2 TSC22 domain family member 2 2 2
MIRT466418 TFAP2A transcription factor AP-2 alpha 2 8
MIRT468278 SFT2D2 SFT2 domain containing 2 2 2
MIRT469399 REL REL proto-oncogene, NF-kB subunit 2 6
MIRT471941 NR6A1 nuclear receptor subfamily 6 group A member 1 2 2
MIRT473688 MAPK8 mitogen-activated protein kinase 8 2 4
MIRT479618 CDC25A cell division cycle 25A 2 2
MIRT482098 AKT3 AKT serine/threonine kinase 3 2 4
MIRT483995 ATAD5 ATPase family, AAA domain containing 5 2 12
MIRT485205 PRKAR2A protein kinase cAMP-dependent type II regulatory subunit alpha 2 8
MIRT498763 C3orf38 chromosome 3 open reading frame 38 2 8
MIRT498961 ORC4 origin recognition complex subunit 4 2 8
MIRT499440 ODF2L outer dense fiber of sperm tails 2 like 2 8
MIRT500080 L2HGDH L-2-hydroxyglutarate dehydrogenase 2 8
MIRT500305 ZNF622 zinc finger protein 622 2 8
MIRT500410 ZMAT3 zinc finger matrin-type 3 2 8
MIRT500789 TLK1 tousled like kinase 1 2 6
MIRT500930 SRPR SRP receptor alpha subunit 2 6
MIRT500943 SREK1 splicing regulatory glutamic acid and lysine rich protein 1 2 8
MIRT501068 SMAD7 SMAD family member 7 2 8
MIRT501711 PARD6B par-6 family cell polarity regulator beta 2 2
MIRT502627 DDX3X DEAD-box helicase 3, X-linked 2 8
MIRT502910 CDCA4 cell division cycle associated 4 2 8
MIRT502935 CDC37L1 cell division cycle 37 like 1 2 8
MIRT504531 ZNF620 zinc finger protein 620 2 6
MIRT505106 YTHDC1 YTH domain containing 1 2 6
MIRT505337 TMEM245 transmembrane protein 245 2 6
MIRT505383 TMEM100 transmembrane protein 100 2 2
MIRT505678 SESTD1 SEC14 and spectrin domain containing 1 2 6
MIRT506157 PLAG1 PLAG1 zinc finger 2 8
MIRT506183 PHKA1 phosphorylase kinase regulatory subunit alpha 1 2 6
MIRT506475 MYO5A myosin VA 2 6
MIRT506826 KIF23 kinesin family member 23 2 6
MIRT507160 GAS2L3 growth arrest specific 2 like 3 2 2
MIRT507511 DYNLL2 dynein light chain LC8-type 2 2 4
MIRT507845 CCNE2 cyclin E2 2 6
MIRT510403 ZNF507 zinc finger protein 507 2 2
MIRT518078 TRIM35 tripartite motif containing 35 2 2
MIRT518982 NNT nicotinamide nucleotide transhydrogenase 2 4
MIRT521045 SLC2A3 solute carrier family 2 member 3 2 4
MIRT521190 SBNO1 strawberry notch homolog 1 2 6
MIRT522088 NUFIP2 NUFIP2, FMR1 interacting protein 2 2 4
MIRT524846 ARPP19 cAMP regulated phosphoprotein 19 2 2
MIRT527787 TMEM44 transmembrane protein 44 2 4
MIRT537803 EFNB2 ephrin B2 2 4
MIRT540830 GNAT1 G protein subunit alpha transducin 1 2 4
MIRT541140 PISD phosphatidylserine decarboxylase 2 2
MIRT541419 CBX4 chromobox 4 2 2
MIRT543517 PRSS21 protease, serine 21 2 2
MIRT543824 GSG1 germ cell associated 1 2 2
MIRT544959 UGT2B4 UDP glucuronosyltransferase family 2 member B4 2 2
MIRT545179 MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2 2 4
MIRT545335 CCDC83 coiled-coil domain containing 83 2 2
MIRT545518 RSL24D1 ribosomal L24 domain containing 1 2 2
MIRT545670 DECR1 2,4-dienoyl-CoA reductase 1 2 2
MIRT545931 ZBTB44 zinc finger and BTB domain containing 44 2 4
MIRT546102 USP48 ubiquitin specific peptidase 48 2 4
MIRT546598 SALL1 spalt like transcription factor 1 2 4
MIRT546626 RTN4 reticulon 4 2 2
MIRT547651 KPNA3 karyopherin subunit alpha 3 2 2
MIRT547987 HCFC2 host cell factor C2 2 4
MIRT548717 CRK CRK proto-oncogene, adaptor protein 2 2
MIRT548931 CDK17 cyclin dependent kinase 17 2 2
MIRT549067 CACUL1 CDK2 associated cullin domain 1 2 2
MIRT549266 ASH1L ASH1 like histone lysine methyltransferase 2 2
MIRT550460 OSCAR osteoclast associated, immunoglobulin-like receptor 2 4
MIRT550806 FAM229B family with sequence similarity 229 member B 2 2
MIRT552024 DNAJC10 DnaJ heat shock protein family (Hsp40) member C10 2 2
MIRT552334 ZNF704 zinc finger protein 704 2 2
MIRT552732 YRDC yrdC N6-threonylcarbamoyltransferase domain containing 2 2
MIRT553795 SZRD1 SUZ RNA binding domain containing 1 2 4
MIRT554694 RNF149 ring finger protein 149 2 2
MIRT555133 PTPRD protein tyrosine phosphatase, receptor type D 2 2
MIRT555264 PRDM4 PR/SET domain 4 2 2
MIRT556848 KANK1 KN motif and ankyrin repeat domains 1 2 4
MIRT557474 GPR27 G protein-coupled receptor 27 2 4
MIRT558018 EXT1 exostosin glycosyltransferase 1 2 2
MIRT558498 CYP26B1 cytochrome P450 family 26 subfamily B member 1 2 4
MIRT558579 CREBL2 cAMP responsive element binding protein like 2 2 4
MIRT558610 COX6B1 cytochrome c oxidase subunit 6B1 2 4
MIRT558650 CNKSR3 CNKSR family member 3 2 2
MIRT558986 CA8 carbonic anhydrase 8 2 2
MIRT559141 BTN3A3 butyrophilin subfamily 3 member A3 2 2
MIRT559327 ATP5G3 ATP synthase, H+ transporting, mitochondrial Fo complex subunit C3 (subunit 9) 2 2
MIRT562021 LANCL1 LanC like 1 2 2
MIRT562869 KIAA1456 KIAA1456 2 2
MIRT563074 SLC25A12 solute carrier family 25 member 12 2 2
MIRT563496 DLGAP3 DLG associated protein 3 2 2
MIRT563890 RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 2 2
MIRT564311 CCNT1 cyclin T1 2 2
MIRT564942 XKR7 XK related 7 2 2
MIRT564979 WNK3 WNK lysine deficient protein kinase 3 2 2
MIRT565423 TEF TEF, PAR bZIP transcription factor 2 2
MIRT566824 MAP3K7 mitogen-activated protein kinase kinase kinase 7 2 2
MIRT571961 KIF5B kinesin family member 5B 2 2
MIRT575877 Cask calcium/calmodulin-dependent serine protein kinase (MAGUK family) 2 3
MIRT576523 Txlna taxilin alpha 2 2
MIRT614693 TRAK1 trafficking kinesin protein 1 2 2
MIRT616065 ZC3H14 zinc finger CCCH-type containing 14 2 2
MIRT618838 ASAH2B N-acylsphingosine amidohydrolase 2B 2 2
MIRT624626 ATXN2 ataxin 2 2 2
MIRT624652 ASAH2 N-acylsphingosine amidohydrolase 2 2 2
MIRT640314 MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 2 2
MIRT659248 CUL3 cullin 3 2 2
MIRT680972 DCAF17 DDB1 and CUL4 associated factor 17 2 2
MIRT682261 RS1 retinoschisin 1 2 2
MIRT682505 GLP2R glucagon like peptide 2 receptor 2 2
MIRT693904 HNRNPA1L2 heterogeneous nuclear ribonucleoprotein A1-like 2 2 2
MIRT699214 SLCO3A1 solute carrier organic anion transporter family member 3A1 2 2
MIRT699373 SLC30A6 solute carrier family 30 member 6 2 2
MIRT699451 SLC16A9 solute carrier family 16 member 9 2 2
MIRT701230 OCRL OCRL, inositol polyphosphate-5-phosphatase 2 2
MIRT702849 HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 2 2
MIRT706163 CASK calcium/calmodulin dependent serine protein kinase 2 3
MIRT718990 UTP15 UTP15, small subunit processome component 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4524a-5p Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (1500 ng/ml)
hsa-miR-4524a-5p Cetuximab resistant tissue (colorectal carcinoma)

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