pre-miRNA Information
pre-miRNA hsa-mir-497   
Genomic Coordinates chr17: 7017911 - 7018022
Synonyms MIRN497, hsa-mir-497, MIR497
Description Homo sapiens miR-497 stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-497-3p
Sequence 64| CAAACCACACUGUGGUGUUAGA |85
Evidence Experimental
Experiments Cloned
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 3 17 - 7017957 29233923 MiREDiBase
A-to-I 4 17 - 7017956 29233923 MiREDiBase
A-to-I 20 17 - 7017940 24964909, 25521855, 27229138, 29165639, 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1413601274 5 dbSNP
rs1028648384 6 dbSNP
rs1479092960 9 dbSNP
rs1261056598 10 dbSNP
rs997278260 11 dbSNP
rs1324708562 13 dbSNP
rs755634302 21 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol SERINC3   
Synonyms AIGP1, DIFF33, SBBI99, TDE, TDE1, TMS-1
Description serine incorporator 3
Transcript NM_006811   
Other Transcripts NM_198941   
Expression
Putative miRNA Targets on SERINC3
3'UTR of SERINC3
(miRNA target sites are highlighted)
>SERINC3|NM_006811|3'UTR
   1 ACCTCTGAGTGCCAAGGACACCACTGGAACTCACAAAGGTCTCCTTCACCGAAAACCCATATACCTTTTAAGTTTGTTTC
  81 AACTAAAATATTAAGTGAATGCTTTGCAAGTTTGACTGTATGCAGGTTTATATCAGAAGGTGAGATTGAATAATGCTTGA
 161 TGCAGAATCGAAACTTCTCATTTATCTGTATATTATGTTTACTTCTAAGGATATAGCACAAAGGGAACATTTTTTGTTTA
 241 AAGTGAACTACAGCTGTGCTGTGAAGAGAGTTCTTTATAAAGCCTGTAGGTTCTTTTAACTTTGGTTTAAAATGTAAGAT
 321 AGGAAAATGTTGGATATTTGAGGCCATGCTTAATATATTTATATTGCAGTATCCTTTAAAAGCAAAAAAAAAAAAATGCA
 401 TTTATATTACAGTTTTCCTCTATGAAAGTCCTTACTTATATGATACAAGCACTGTGTTTTGTGCTTAAACTCTTCAGCGG
 481 GGTAGCATCAAAGTTCTTGGGGAAGGATCGTATATGTGGGTCCCTTCCCTAGAAGAATGGTTGCTGATATGGCTACTGCT
 561 TCTACATCTTGAGTTTTTTAATTTACTTTTTTTACACTGTAGCATTGAGACTGCTTGATTCAAGTCTGGTGCTTTGCCAG
 641 ATGTATTAATTTCCATAAATGCTTTGTGAGTTTGGTTAAAATGAAGATTCACTTGGGAAAACACTGCAGCTTTAGTCTGT
 721 GTTACTATCTTGTTATGAGTATGTAAAAGTAAAATGCATGTGAATTTATCATATTTGCACTATGAAGGTATTTGGTTAAA
 801 ATACAAAGACTTTTAAGATTTTAAGGCCCTTTCTTCCAACAGCTTTTATAGTTAGCAGCCATTCTTTATTTTCTGGATAG
 881 CCAGGTTTTATCACGCTTCTAGTCAGGATGCTCCTATTCCTTCTAAAAATTACGGTCTGACTAGTGAGCAAAGTCTTGAA
 961 TTTATTCAAAAGTCCTAAATACCTTCTCTAGGTAAGACACTTGGTAGATGAGAGACGGAAGGCATTGTCAAGAACCATTT
1041 TCATGAGAGGTGGTGTGCAAAAAGGTAGAATAAAAGAGTTCTTTCAACAAAGATTTACTGTCTATTCTGTACTAGACCCT
1121 GTAGGTTTTGGGGTACAGTGTTAAACATGATAGAGGCTCTGCCGTCTTGGACTTTAATAGCTTAGAGAAGAGAGCAAATG
1201 AGCTGACAGGTGGTTATAATGTGAATTAGTGCTGTGGTTTAGGAATTGGAGAGAACTCAAAGGAGAGGTATTTGGTGTAA
1281 TGGTAGGCTTTCTGGAGAAAATGATATTTAAGCCAAGAACTCTTAGAAGTTAGCTAAGAGAGAGATGGGAAAATGAGACG
1361 ACATTGCTGGAGTAGATAAAACTGCATGTTAAAGGCAGGAAGATGGGGAAAAAAAGTTCAGTAAAGCTGGAATGGGGAAA
1441 TGTAGTCAGGGACTGAATTTTAAAGGGCTTTATCAACCTCAGTAAAGAGTTTGGACCTTATGTTGAGGGTGGCTGAAAAC
1521 ATATTCATAGTGTCATGAACAAATTTTATCTTCAGTCACTTGGGCTGATATATAGAGAATGGATTTAGAGAGATGAGACC
1601 AGGTGCAGTCCATATGAGATGTGAAATAGAGAAGTGGAATCGTAGGGACGGGGAGAAATTGACAGGTGAGGGCTACTTAG
1681 CAATTAGAATTTTTTTTTTTCAATTTTAATTTTTTTTTTTGAGACGGAGTCTTGCTCTGTCGCCCAGGCTGGAGTGCAAT
1761 GGTGCGATCTCCGCTCACTGCAGGCTCCGCCTCCCGGGTTCACGCCATTCTCCCGCCTCAGCCTCCCTAGTAGCTGGGAC
1841 TACAGGCACCCACCACCACGCCTGGCTAATTTTTTTTGTATTTTTAGTAGAGACAGGGTTTCACCATGTTAGCCAGGATG
1921 GTCTCGATCTCCTGACCTCGTGATCCACCTGCCGCGGCCTCCCAAAGTTCTAGGATTACTGGCATGAGCCACCGTGCCTG
2001 GCCAGCAATTAGAATTTTAACACTGGCAGTTATGAATAATATGAAGGAGAGGTAGATTTCTGAGTGATTCTGGTTTAACC
2081 AGCTGGGTGGATGGTGGTTCCACGTATTCAGGTGGCAAACAGGAAAAACATGTGTTCGAAGAAGAATGGAGGTAGGTGGT
2161 CTCTTAAGAATGGTTAAGAGGCTTGGGAGTCAGACTGCTTGGGTTTGCATCCCAGCTTTGCCGTTTTCTGGCTATCAAAC
2241 TTGTCAGCTATTATTTGTTGAGTACGTACTATTTGATTTATGACCACAGGCAGCTGAGCCTCAGTGTTGGTGCCTAGTGT
2321 ACAAGATTGTTAAAGAATAAAGTTATTTTGCAAAGTGTAACCCATTTTTAGCACTGACATAGCACTGACAGTAGCTGCTG
2401 ATCTCATTATGGGCTAAAATAAGACAATATTCAAAGGTCAGAGATATCTAGCCAGAATCTGATGGAGGCTGGATTTCAGA
2481 TTTTGTTACAGAATTAGACAGAGGAACACAGAGGGGACAGGCTCAGTTAGGGTGGAGGTGTGGGGTAGGGAAGCAGGACT
2561 TGATATAAATTATTGGAATCATTGTCTTTTAAACCAGTGGTTTATGTCAGGGTATAGCGTTTCAAGGGATTTGAGGGTCA
2641 GATGGGGAAATGTAGCCCCTTATTTTGCCAGTGTGAAGCAGATACCCTGCTTTTCTTTACAGTAGCGGAGTCAGCTTAAG
2721 AGCTTTAAAGGTCCTAAACTTCAAAAACATTACAGTGCCCCATCCTCCGCCTTAATGTAATTCAAAATACAAACAATACT
2801 AAACTGTAAAATAAATGTAACAAAGTCCAATAAAGTTTTTATTTTTTTCTCATGATAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' agAUUGUGGU--GUC---ACACCAAAc 5'
            |||::: |  :||   |||||||| 
Target 5' taTAATGTGAATTAGTGCTGTGGTTTa 3'
1215 - 1241 154.00 -9.70
2
miRNA  3' agAUUGUGGUGUCACACCAAAc 5'
            ||| ||||    ||||||| 
Target 5' ttTAA-ACCA----GTGGTTTa 3'
2588 - 2604 153.00 -9.20
3
miRNA  3' agAUUGUGGU-GUCACACCAAAc 5'
            |:|:|| | || |||| ||| 
Target 5' taTGATACAAGCACTGTGTTTTg 3'
439 - 461 136.00 -11.60
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30472816 4 COSMIC
COSN30153320 5 COSMIC
COSN30456249 16 COSMIC
COSN26599700 19 COSMIC
COSN30459812 26 COSMIC
COSN30538181 37 COSMIC
COSN5765069 66 COSMIC
COSN30135438 103 COSMIC
COSN4893129 109 COSMIC
COSN30116935 156 COSMIC
COSN22882155 229 COSMIC
COSN26666741 236 COSMIC
COSN31590791 254 COSMIC
COSN27577136 383 COSMIC
COSN19664486 384 COSMIC
COSN20116468 396 COSMIC
COSN31569650 398 COSMIC
COSN24591222 546 COSMIC
COSN10016380 704 COSMIC
COSN9129855 1231 COSMIC
COSN16090353 1495 COSMIC
COSN29100297 1652 COSMIC
COSN25667104 2054 COSMIC
COSN32168647 2798 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs749819167 4 dbSNP
rs773286690 7 dbSNP
rs1324194755 11 dbSNP
rs773838313 12 dbSNP
rs180819328 19 dbSNP
rs770190299 23 dbSNP
rs538818371 29 dbSNP
rs1270853233 33 dbSNP
rs570040913 34 dbSNP
rs1057016339 37 dbSNP
rs778767478 38 dbSNP
rs1349567643 39 dbSNP
rs201993367 40 dbSNP
rs1439108618 41 dbSNP
rs774678122 44 dbSNP
rs1323513943 49 dbSNP
rs374707242 50 dbSNP
rs758121490 51 dbSNP
rs761477858 57 dbSNP
rs911761716 58 dbSNP
rs903160499 59 dbSNP
rs6103756 62 dbSNP
rs1376666987 96 dbSNP
rs1450966719 109 dbSNP
rs1215806921 118 dbSNP
rs987322166 120 dbSNP
rs1176374112 138 dbSNP
rs1481278496 139 dbSNP
rs1192443321 140 dbSNP
rs950718209 146 dbSNP
rs1475714504 167 dbSNP
rs1802899 169 dbSNP
rs530463519 170 dbSNP
rs1389125230 185 dbSNP
rs1421275652 186 dbSNP
rs1405308249 188 dbSNP
rs1026217952 190 dbSNP
rs1347005222 197 dbSNP
rs1398277907 197 dbSNP
rs1488616500 205 dbSNP
rs1263772968 207 dbSNP
rs748944290 209 dbSNP
rs1297764142 211 dbSNP
rs947524825 217 dbSNP
rs973699473 219 dbSNP
rs1234833184 230 dbSNP
rs1355450149 239 dbSNP
rs13786 245 dbSNP
rs963059761 252 dbSNP
rs776208764 255 dbSNP
rs921328903 256 dbSNP
rs772490086 259 dbSNP
rs944202224 261 dbSNP
rs1215285482 265 dbSNP
rs1257735675 266 dbSNP
rs1486452616 273 dbSNP
rs754772608 282 dbSNP
rs906273553 283 dbSNP
rs983013376 302 dbSNP
rs1009717318 306 dbSNP
rs190784293 312 dbSNP
rs1410823747 315 dbSNP
rs950452058 321 dbSNP
rs892737060 329 dbSNP
rs1224403024 330 dbSNP
rs1054053670 334 dbSNP
rs548121774 335 dbSNP
rs1339622365 349 dbSNP
rs79486086 350 dbSNP
rs1281163603 357 dbSNP
rs963164492 368 dbSNP
rs779326962 369 dbSNP
rs1327469972 377 dbSNP
rs1238713065 382 dbSNP
rs1320876992 383 dbSNP
rs1349498487 384 dbSNP
rs1012765623 395 dbSNP
rs1208235121 397 dbSNP
rs1491136795 397 dbSNP
rs201996287 397 dbSNP
rs34126743 397 dbSNP
rs397865094 397 dbSNP
rs57945134 398 dbSNP
rs749685651 398 dbSNP
rs912631428 400 dbSNP
rs6017354 406 dbSNP
rs998754064 408 dbSNP
rs1401794415 419 dbSNP
rs1410284344 421 dbSNP
rs1400919780 422 dbSNP
rs6073459 431 dbSNP
rs903087026 435 dbSNP
rs1043086784 438 dbSNP
rs1374499278 439 dbSNP
rs749774783 439 dbSNP
rs546044438 449 dbSNP
rs6073458 452 dbSNP
rs1372508627 454 dbSNP
rs778028560 457 dbSNP
rs1470786005 460 dbSNP
rs1339663693 461 dbSNP
rs577093554 478 dbSNP
rs1275535566 479 dbSNP
rs1169617543 482 dbSNP
rs1178537009 493 dbSNP
rs1475628322 496 dbSNP
rs1374679717 504 dbSNP
rs1185375606 507 dbSNP
rs752977540 510 dbSNP
rs781493389 513 dbSNP
rs1462704246 534 dbSNP
rs563612054 537 dbSNP
rs983450226 538 dbSNP
rs1397847003 544 dbSNP
rs1464948901 545 dbSNP
rs543734675 549 dbSNP
rs187060362 550 dbSNP
rs970488978 553 dbSNP
rs930269449 555 dbSNP
rs1455267030 556 dbSNP
rs1326563500 562 dbSNP
rs1229149523 564 dbSNP
rs1024711819 566 dbSNP
rs920152663 567 dbSNP
rs554673631 573 dbSNP
rs574957357 579 dbSNP
rs1001160868 580 dbSNP
rs1243314546 589 dbSNP
rs756237106 594 dbSNP
rs74695414 595 dbSNP
rs1039705211 598 dbSNP
rs1292003431 610 dbSNP
rs1421784472 618 dbSNP
rs1477347735 621 dbSNP
rs991216742 624 dbSNP
rs1008172353 628 dbSNP
rs1315224305 629 dbSNP
rs755223327 637 dbSNP
rs1035558502 638 dbSNP
rs576581332 639 dbSNP
rs967361225 643 dbSNP
rs1021952428 644 dbSNP
rs558604161 654 dbSNP
rs1047161195 667 dbSNP
rs1294308659 670 dbSNP
rs751368172 673 dbSNP
rs1330296150 688 dbSNP
rs1265415897 690 dbSNP
rs1410287762 702 dbSNP
rs1218925837 723 dbSNP
rs1261214312 723 dbSNP
rs930013621 727 dbSNP
rs899805574 732 dbSNP
rs1258007236 736 dbSNP
rs1039778824 739 dbSNP
rs1421876144 745 dbSNP
rs1163959963 746 dbSNP
rs1364336232 752 dbSNP
rs1037930686 755 dbSNP
rs941964668 756 dbSNP
rs150793890 760 dbSNP
rs1359438399 764 dbSNP
rs1184222529 769 dbSNP
rs980460457 771 dbSNP
rs1381759408 772 dbSNP
rs1446544365 773 dbSNP
rs970392588 780 dbSNP
rs141271920 782 dbSNP
rs1242328704 783 dbSNP
rs13568 790 dbSNP
rs1283955071 801 dbSNP
rs138662787 813 dbSNP
rs373784456 815 dbSNP
rs766172978 819 dbSNP
rs1208575449 828 dbSNP
rs536548455 837 dbSNP
rs1482126227 843 dbSNP
rs956653744 847 dbSNP
rs1047248300 850 dbSNP
rs1441483413 851 dbSNP
rs930129706 853 dbSNP
rs1379152364 870 dbSNP
rs1434847142 874 dbSNP
rs1175106932 876 dbSNP
rs762835851 877 dbSNP
rs979554515 881 dbSNP
rs920199725 882 dbSNP
rs1302647707 890 dbSNP
rs964293912 891 dbSNP
rs1038592674 894 dbSNP
rs941695584 900 dbSNP
rs8538 902 dbSNP
rs1235146196 917 dbSNP
rs991141802 920 dbSNP
rs1280951156 933 dbSNP
rs6606 934 dbSNP
rs928373094 948 dbSNP
rs1209094984 953 dbSNP
rs977314221 967 dbSNP
rs967579709 969 dbSNP
rs891131767 990 dbSNP
rs761248265 992 dbSNP
rs1237549283 994 dbSNP
rs1011422903 1016 dbSNP
rs528063179 1017 dbSNP
rs1422546512 1019 dbSNP
rs1432219264 1024 dbSNP
rs1170787677 1026 dbSNP
rs898570695 1031 dbSNP
rs1329847701 1043 dbSNP
rs1400255094 1047 dbSNP
rs1441642276 1050 dbSNP
rs964026327 1050 dbSNP
rs1365656422 1052 dbSNP
rs1321259470 1053 dbSNP
rs1404562440 1055 dbSNP
rs1037563974 1057 dbSNP
rs559213646 1058 dbSNP
rs776115402 1059 dbSNP
rs904995691 1064 dbSNP
rs1426593132 1065 dbSNP
rs1008164152 1073 dbSNP
rs891249399 1082 dbSNP
rs1244467934 1087 dbSNP
rs1045019532 1094 dbSNP
rs1047557117 1104 dbSNP
rs917597546 1105 dbSNP
rs988211909 1107 dbSNP
rs6031631 1112 dbSNP
rs1423463806 1118 dbSNP
rs1234821997 1119 dbSNP
rs532391451 1121 dbSNP
rs1197131990 1132 dbSNP
rs1326193179 1143 dbSNP
rs78697396 1146 dbSNP
rs925013050 1150 dbSNP
rs1435914172 1155 dbSNP
rs1298983816 1156 dbSNP
rs1342650241 1157 dbSNP
rs1216503407 1159 dbSNP
rs898635803 1163 dbSNP
rs543599205 1164 dbSNP
rs1320539824 1171 dbSNP
rs866645618 1175 dbSNP
rs1027990339 1177 dbSNP
rs760357682 1179 dbSNP
rs1264800464 1192 dbSNP
rs1487112185 1197 dbSNP
rs1192561798 1207 dbSNP
rs1018358806 1210 dbSNP
rs370883780 1212 dbSNP
rs574657308 1220 dbSNP
rs1350840419 1223 dbSNP
rs1284767885 1245 dbSNP
rs1223854468 1263 dbSNP
rs1412298061 1264 dbSNP
rs1404802614 1265 dbSNP
rs35693665 1267 dbSNP
rs1159338490 1269 dbSNP
rs1352473538 1271 dbSNP
rs866147164 1277 dbSNP
rs1362596348 1287 dbSNP
rs1398376289 1307 dbSNP
rs1297861462 1308 dbSNP
rs1272696474 1310 dbSNP
rs955806871 1316 dbSNP
rs561207139 1317 dbSNP
rs1355562134 1319 dbSNP
rs994555705 1329 dbSNP
rs1223800136 1338 dbSNP
rs541093342 1346 dbSNP
rs898608673 1350 dbSNP
rs1350958174 1352 dbSNP
rs1215403975 1358 dbSNP
rs1280663674 1360 dbSNP
rs1055510344 1365 dbSNP
rs1345868705 1373 dbSNP
rs1190091964 1374 dbSNP
rs1017043168 1378 dbSNP
rs1472747869 1381 dbSNP
rs938340598 1382 dbSNP
rs928410186 1398 dbSNP
rs977534397 1399 dbSNP
rs1304903332 1409 dbSNP
rs949370962 1415 dbSNP
rs896377431 1430 dbSNP
rs771290458 1431 dbSNP
rs935007811 1438 dbSNP
rs1447421899 1442 dbSNP
rs1398007496 1445 dbSNP
rs1358706369 1446 dbSNP
rs924950122 1447 dbSNP
rs1275038496 1451 dbSNP
rs34415282 1452 dbSNP
rs1346695670 1458 dbSNP
rs979154274 1467 dbSNP
rs1276937446 1471 dbSNP
rs1442243554 1475 dbSNP
rs967253237 1477 dbSNP
rs1240594222 1482 dbSNP
rs1317804343 1484 dbSNP
rs778615108 1487 dbSNP
rs1178103861 1488 dbSNP
rs914378289 1495 dbSNP
rs1410497530 1496 dbSNP
rs572388056 1497 dbSNP
rs989927844 1501 dbSNP
rs911426251 1505 dbSNP
rs986925426 1511 dbSNP
rs963952934 1521 dbSNP
rs955672013 1524 dbSNP
rs1465992297 1526 dbSNP
rs558665692 1535 dbSNP
rs749833207 1542 dbSNP
rs918820668 1554 dbSNP
rs182073634 1558 dbSNP
rs1487634504 1561 dbSNP
rs778363906 1571 dbSNP
rs955518078 1572 dbSNP
rs1242034750 1575 dbSNP
rs1273927486 1575 dbSNP
rs1323211200 1580 dbSNP
rs1025746586 1584 dbSNP
rs994630916 1588 dbSNP
rs769996054 1589 dbSNP
rs1260476437 1592 dbSNP
rs1016903066 1593 dbSNP
rs1215950078 1596 dbSNP
rs748300444 1600 dbSNP
rs970121118 1601 dbSNP
rs1453442015 1605 dbSNP
rs766763346 1608 dbSNP
rs1023498077 1615 dbSNP
rs553957734 1625 dbSNP
rs1377309636 1628 dbSNP
rs1013825617 1631 dbSNP
rs1172565383 1640 dbSNP
rs576081420 1641 dbSNP
rs1017140143 1642 dbSNP
rs1012420321 1648 dbSNP
rs764572201 1649 dbSNP
rs1056695035 1650 dbSNP
rs538666811 1651 dbSNP
rs1052803159 1654 dbSNP
rs999410983 1664 dbSNP
rs906836892 1670 dbSNP
rs189812442 1679 dbSNP
rs1041478131 1680 dbSNP
rs536821393 1687 dbSNP
rs1431622104 1689 dbSNP
rs1043366709 1700 dbSNP
rs1358502240 1701 dbSNP
rs942493834 1701 dbSNP
rs910951199 1706 dbSNP
rs1268371276 1708 dbSNP
rs945814362 1709 dbSNP
rs567888852 1710 dbSNP
rs1196198591 1712 dbSNP
rs1051232633 1721 dbSNP
rs1176824292 1721 dbSNP
rs1260721217 1721 dbSNP
rs1370151648 1721 dbSNP
rs1346994751 1722 dbSNP
rs1332460462 1725 dbSNP
rs914304665 1726 dbSNP
rs1469427222 1727 dbSNP
rs989980047 1735 dbSNP
rs775656873 1737 dbSNP
rs1314017843 1739 dbSNP
rs973394836 1740 dbSNP
rs911140943 1741 dbSNP
rs554427594 1742 dbSNP
rs987099512 1743 dbSNP
rs1354546842 1752 dbSNP
rs373852854 1759 dbSNP
rs1419477694 1764 dbSNP
rs1026094122 1765 dbSNP
rs972742837 1766 dbSNP
rs1476121808 1769 dbSNP
rs1258110314 1771 dbSNP
rs962829658 1772 dbSNP
rs770199107 1773 dbSNP
rs1461543875 1775 dbSNP
rs1264601523 1778 dbSNP
rs6093988 1783 dbSNP
rs1156407969 1784 dbSNP
rs1359535653 1787 dbSNP
rs565673303 1788 dbSNP
rs895276316 1789 dbSNP
rs552152452 1795 dbSNP
rs1004171720 1796 dbSNP
rs532252310 1797 dbSNP
rs902751417 1803 dbSNP
rs1041798778 1804 dbSNP
rs569731242 1810 dbSNP
rs550020525 1811 dbSNP
rs755203799 1814 dbSNP
rs892921369 1815 dbSNP
rs1054095002 1818 dbSNP
rs942556519 1822 dbSNP
rs577639755 1828 dbSNP
rs1176271714 1833 dbSNP
rs1440928438 1833 dbSNP
rs1406722373 1835 dbSNP
rs1433383728 1837 dbSNP
rs112877597 1845 dbSNP
rs1379723630 1848 dbSNP
rs986638099 1851 dbSNP
rs1338912527 1852 dbSNP
rs1401707307 1854 dbSNP
rs1449027228 1858 dbSNP
rs45550139 1859 dbSNP
rs903779449 1861 dbSNP
rs1354263638 1878 dbSNP
rs1043396524 1879 dbSNP
rs918510807 1880 dbSNP
rs1222676025 1889 dbSNP
rs889421554 1893 dbSNP
rs1196722088 1895 dbSNP
rs1051308212 1906 dbSNP
rs973180392 1925 dbSNP
rs1479640184 1926 dbSNP
rs1412256669 1932 dbSNP
rs962670057 1939 dbSNP
rs1424851778 1943 dbSNP
rs918756705 1945 dbSNP
rs909969712 1949 dbSNP
rs148820424 1953 dbSNP
rs374849925 1954 dbSNP
rs1480198062 1955 dbSNP
rs370330854 1956 dbSNP
rs78639079 1959 dbSNP
rs6103755 1973 dbSNP
rs1319777903 1982 dbSNP
rs980323107 1985 dbSNP
rs1272225793 1989 dbSNP
rs967402991 1990 dbSNP
rs750366110 1994 dbSNP
rs1223174796 1996 dbSNP
rs765225654 2002 dbSNP
rs1490078620 2003 dbSNP
rs1193987231 2007 dbSNP
rs892781981 2014 dbSNP
rs771685927 2022 dbSNP
rs1360208017 2027 dbSNP
rs576145215 2036 dbSNP
rs917217923 2038 dbSNP
rs1479040772 2039 dbSNP
rs1054146597 2042 dbSNP
rs1006624355 2043 dbSNP
rs1419429786 2043 dbSNP
rs556211926 2049 dbSNP
rs889515176 2051 dbSNP
rs757177401 2053 dbSNP
rs1299168029 2059 dbSNP
rs1051411452 2062 dbSNP
rs933834202 2067 dbSNP
rs977934273 2080 dbSNP
rs918509638 2086 dbSNP
rs1299099720 2092 dbSNP
rs1342122465 2096 dbSNP
rs1397924523 2103 dbSNP
rs967965911 2104 dbSNP
rs1022180367 2108 dbSNP
rs1006738752 2110 dbSNP
rs889452383 2112 dbSNP
rs1358191984 2118 dbSNP
rs184927218 2122 dbSNP
rs1036913819 2126 dbSNP
rs941358946 2128 dbSNP
rs1029294134 2129 dbSNP
rs952371209 2130 dbSNP
rs147451600 2132 dbSNP
rs574163754 2137 dbSNP
rs959467051 2138 dbSNP
rs1383453028 2147 dbSNP
rs1418077310 2152 dbSNP
rs753398579 2160 dbSNP
rs879013345 2164 dbSNP
rs1037635688 2170 dbSNP
rs569869913 2171 dbSNP
rs966867596 2175 dbSNP
rs1359568961 2188 dbSNP
rs1450124118 2190 dbSNP
rs6031630 2192 dbSNP
rs548181053 2195 dbSNP
rs1381327071 2202 dbSNP
rs888594566 2208 dbSNP
rs958269616 2215 dbSNP
rs1044673910 2216 dbSNP
rs1032663920 2222 dbSNP
rs1006511768 2223 dbSNP
rs1223073843 2232 dbSNP
rs148250214 2233 dbSNP
rs1293959783 2234 dbSNP
rs768536914 2238 dbSNP
rs1050833900 2248 dbSNP
rs534507256 2265 dbSNP
rs1225871892 2266 dbSNP
rs763631407 2280 dbSNP
rs1468771058 2285 dbSNP
rs924705036 2296 dbSNP
rs896962237 2300 dbSNP
rs1037368226 2303 dbSNP
rs1425594136 2309 dbSNP
rs979225343 2324 dbSNP
rs760278996 2332 dbSNP
rs1334533142 2339 dbSNP
rs1158089004 2340 dbSNP
rs775156900 2343 dbSNP
rs1405303237 2357 dbSNP
rs967873142 2358 dbSNP
rs1332765463 2360 dbSNP
rs1022044553 2362 dbSNP
rs766663127 2364 dbSNP
rs571926461 2367 dbSNP
rs1275129285 2375 dbSNP
rs1346078283 2376 dbSNP
rs979962881 2379 dbSNP
rs554747428 2380 dbSNP
rs969942803 2391 dbSNP
rs937986614 2393 dbSNP
rs1199872022 2395 dbSNP
rs1431251812 2401 dbSNP
rs1428273185 2407 dbSNP
rs1200068111 2410 dbSNP
rs1436211829 2411 dbSNP
rs1181286503 2413 dbSNP
rs928045571 2416 dbSNP
rs1247516513 2418 dbSNP
rs1490839527 2427 dbSNP
rs1478863992 2440 dbSNP
rs997842505 2448 dbSNP
rs1260918545 2453 dbSNP
rs1428396715 2462 dbSNP
rs982178387 2463 dbSNP
rs558599538 2473 dbSNP
rs1466045959 2488 dbSNP
rs1172811348 2494 dbSNP
rs1393673459 2497 dbSNP
rs1256539922 2499 dbSNP
rs796270772 2503 dbSNP
rs1485565755 2504 dbSNP
rs1323729913 2516 dbSNP
rs1332487482 2520 dbSNP
rs73615464 2521 dbSNP
rs1218150327 2522 dbSNP
rs1219771030 2537 dbSNP
rs1015364427 2538 dbSNP
rs1005269164 2542 dbSNP
rs1195332376 2547 dbSNP
rs1290799786 2551 dbSNP
rs914103782 2557 dbSNP
rs377390572 2562 dbSNP
rs376401328 2565 dbSNP
rs1282960902 2567 dbSNP
rs191918653 2574 dbSNP
rs1195677379 2578 dbSNP
rs1371267284 2580 dbSNP
rs1222139413 2584 dbSNP
rs1347991883 2594 dbSNP
rs1461004072 2595 dbSNP
rs1326436911 2596 dbSNP
rs1392310370 2596 dbSNP
rs1044576055 2606 dbSNP
rs866463673 2611 dbSNP
rs1302212516 2612 dbSNP
rs958322877 2618 dbSNP
rs74877209 2619 dbSNP
rs1227404689 2621 dbSNP
rs985102632 2628 dbSNP
rs529886693 2636 dbSNP
rs1361764286 2637 dbSNP
rs1220516474 2639 dbSNP
rs934691742 2641 dbSNP
rs924582702 2642 dbSNP
rs1206700730 2651 dbSNP
rs953699778 2653 dbSNP
rs1259461955 2659 dbSNP
rs1467844598 2664 dbSNP
rs1427824333 2679 dbSNP
rs1188247073 2682 dbSNP
rs1369684236 2685 dbSNP
rs1404895893 2687 dbSNP
rs1176965950 2688 dbSNP
rs1029846751 2700 dbSNP
rs1420641572 2703 dbSNP
rs2664561 2705 dbSNP
rs188665544 2706 dbSNP
rs1383310930 2707 dbSNP
rs141066935 2707 dbSNP
rs1314133122 2709 dbSNP
rs1385006064 2715 dbSNP
rs2664547 2720 dbSNP
rs1314578450 2723 dbSNP
rs748641847 2731 dbSNP
rs776612420 2733 dbSNP
rs527590600 2739 dbSNP
rs15254 2742 dbSNP
rs768738959 2748 dbSNP
rs1207119987 2759 dbSNP
rs1485456844 2760 dbSNP
rs564804579 2768 dbSNP
rs954121458 2769 dbSNP
rs888398785 2782 dbSNP
rs545024736 2791 dbSNP
rs1262729759 2816 dbSNP
rs1204762560 2827 dbSNP
rs1459559877 2828 dbSNP
rs116302270 2835 dbSNP
rs1380429958 2844 dbSNP
rs1420470528 2849 dbSNP
rs2664559 2849 dbSNP
rs977051973 2849 dbSNP
rs558945823 2855 dbSNP
rs1362407809 2856 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions Hela
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1048187. RNA binding protein: AGO2. Condition:Hela_AGO2_CLIP_control ...

- Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al., 2013, Cell.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' agaUUGUGGUGUCACACCAAac 5'
             |:| : |||| ||||||  
Target 5' ---AGC-UGACAG-GUGGUUau 3'
1 - 17
Article - Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al.
- Cell, 2013
The induction of pluripotency or trans-differentiation of one cell type to another can be accomplished with cell-lineage-specific transcription factors. Here, we report that repression of a single RNA binding polypyrimidine-tract-binding (PTB) protein, which occurs during normal brain development via the action of miR-124, is sufficient to induce trans-differentiation of fibroblasts into functional neurons. Besides its traditional role in regulated splicing, we show that PTB has a previously undocumented function in the regulation of microRNA functions, suppressing or enhancing microRNA targeting by competitive binding on target mRNA or altering local RNA secondary structure. A key event during neuronal induction is the relief of PTB-mediated blockage of microRNA action on multiple components of the REST complex, thereby derepressing a large array of neuronal genes, including miR-124 and multiple neuronal-specific transcription factors, in nonneuronal cells. This converts a negative feedback loop to a positive one to elicit cellular reprogramming to the neuronal lineage.
LinkOut: [PMID: 23313552]
CLIP-seq Support 1 for dataset GSM1048187
Method / RBP HITS-CLIP / AGO2
Cell line / Condition Hela / Hela_AGO2_CLIP_control
Location of target site ENST00000342374.4 | 3UTR | AGCUGACAGGUGGUUAUAAUGUGAAUUAGUGCUGUGG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23313552 / GSE42701
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE42095 Differentiated embryonic stem cells 0.833 4.1e-7 0.637 5.4e-4 23 Click to see details
GSE28260 Renal cortex and medulla 0.819 3.1e-4 0.795 5.8e-4 13 Click to see details
GSE21687 Ependynoma primary tumors -0.278 1.3e-2 -0.345 2.6e-3 64 Click to see details
GSE26953 Aortic valvular endothelial cells 0.431 1.8e-2 0.490 7.5e-3 24 Click to see details
GSE38226 Liver fibrosis -0.348 6.1e-2 -0.275 1.1e-1 21 Click to see details
GSE38974 Chronic obstructive pulmonary disease -0.213 1.5e-1 -0.368 3.5e-2 25 Click to see details
GSE19350 CNS germ cell tumors -0.305 1.7e-1 0.133 3.4e-1 12 Click to see details
GSE28544 Breast cancer -0.181 2.0e-1 -0.174 2.1e-1 24 Click to see details
GSE32688 Pancreatic cancer 0.153 2.0e-1 0.020 4.6e-1 32 Click to see details
GSE17498 Multiple myeloma -0.045 3.9e-1 -0.166 1.5e-1 40 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis -0.03 4.5e-1 -0.459 2.1e-2 20 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis -0.03 4.5e-1 -0.459 2.1e-2 20 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis -0.03 4.5e-1 -0.459 2.1e-2 20 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
BLCA -0.897 0.05 -0.800 0.1 4 Click to see details
LUSC 0.172 0.18 0.065 0.37 30 Click to see details
HNSC -0.222 0.19 -0.024 0.46 18 Click to see details
ESCA -0.276 0.22 -0.200 0.29 10 Click to see details
LUAD -0.551 0.22 -0.400 0.3 4 Click to see details
KIRC 0.098 0.27 0.146 0.18 43 Click to see details
PRAD -0.093 0.27 -0.147 0.16 46 Click to see details
BRCA 0.077 0.31 0.097 0.27 42 Click to see details
LIHC -0.088 0.32 -0.045 0.41 30 Click to see details
UCEC 0.096 0.36 0.194 0.24 16 Click to see details
THCA 0.052 0.37 0.150 0.16 45 Click to see details
PAAD 0.193 0.4 0.400 0.3 4 Click to see details
CHOL 0.088 0.43 0.143 0.39 6 Click to see details
KIRP -0.038 0.44 0.027 0.45 21 Click to see details
STAD 0.015 0.47 0.052 0.41 21 Click to see details
KICH 0.003 0.5 0.186 0.25 15 Click to see details
KICH 0.003 0.5 0.186 0.25 15 Click to see details
KICH 0.003 0.5 0.186 0.25 15 Click to see details
KICH 0.003 0.5 0.186 0.25 15 Click to see details
95 hsa-miR-497-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT092955 CYP2U1 cytochrome P450 family 2 subfamily U member 1 2 4
MIRT124568 PRRC2B proline rich coiled-coil 2B 2 2
MIRT125196 EIF1AX eukaryotic translation initiation factor 1A, X-linked 2 4
MIRT147296 KPNA2 karyopherin subunit alpha 2 2 8
MIRT163999 KIAA1109 KIAA1109 2 4
MIRT252495 NWD1 NACHT and WD repeat domain containing 1 2 2
MIRT357969 GRPEL2 GrpE like 2, mitochondrial 2 2
MIRT443007 TRIOBP TRIO and F-actin binding protein 2 2
MIRT443524 NETO1 neuropilin and tolloid like 1 2 2
MIRT443573 EVX2 even-skipped homeobox 2 2 2
MIRT443656 BACH1 BTB domain and CNC homolog 1 2 2
MIRT460670 KRT10 keratin 10 2 8
MIRT464761 UBE2N ubiquitin conjugating enzyme E2 N 2 2
MIRT465032 LINC00598 long intergenic non-protein coding RNA 598 2 2
MIRT465040 TTC39C tetratricopeptide repeat domain 39C 2 2
MIRT468667 SEC62 SEC62 homolog, preprotein translocation factor 2 2
MIRT473694 MAPK8 mitogen-activated protein kinase 8 2 4
MIRT477618 EFNA3 ephrin A3 2 2
MIRT480506 C11orf57 chromosome 11 open reading frame 57 2 2
MIRT480592 BUB3 BUB3, mitotic checkpoint protein 2 2
MIRT486915 ZNF398 zinc finger protein 398 2 6
MIRT487770 ANKEF1 ankyrin repeat and EF-hand domain containing 1 2 16
MIRT493265 MDFIC MyoD family inhibitor domain containing 2 2
MIRT495271 SLC1A2 solute carrier family 1 member 2 2 4
MIRT495309 CHST12 carbohydrate sulfotransferase 12 2 2
MIRT496681 DPP6 dipeptidyl peptidase like 6 2 4
MIRT496891 FOXP1 forkhead box P1 2 2
MIRT497330 IRF4 interferon regulatory factor 4 2 2
MIRT498272 KIAA1644 KIAA1644 2 2
MIRT498634 CHD4 chromodomain helicase DNA binding protein 4 2 10
MIRT500581 USP53 ubiquitin specific peptidase 53 2 2
MIRT500751 TMPPE transmembrane protein with metallophosphoesterase domain 2 6
MIRT509668 ZNF354B zinc finger protein 354B 2 10
MIRT510919 PSMA2 proteasome subunit alpha 2 2 4
MIRT519118 CEP76 centrosomal protein 76 2 2
MIRT526193 ABCG2 ATP binding cassette subfamily G member 2 (Junior blood group) 2 2
MIRT526746 HLA-DOB major histocompatibility complex, class II, DO beta 2 2
MIRT527270 FBLN2 fibulin 2 2 2
MIRT528198 PLEKHM2 pleckstrin homology and RUN domain containing M2 2 2
MIRT528330 TBC1D22B TBC1 domain family member 22B 2 2
MIRT530346 GABRB3 gamma-aminobutyric acid type A receptor beta3 subunit 2 2
MIRT533627 TMX3 thioredoxin related transmembrane protein 3 2 2
MIRT533738 TMEM200C transmembrane protein 200C 2 2
MIRT533779 TMEM133 transmembrane protein 133 2 2
MIRT534317 SKIDA1 SKI/DACH domain containing 1 2 2
MIRT538438 COG5 component of oligomeric golgi complex 5 2 2
MIRT539156 AREL1 apoptosis resistant E3 ubiquitin protein ligase 1 2 2
MIRT539474 ADARB2 adenosine deaminase, RNA specific B2 (inactive) 2 2
MIRT539620 SHISA9 shisa family member 9 2 2
MIRT539650 BUB1 BUB1 mitotic checkpoint serine/threonine kinase 2 2
MIRT540346 OPHN1 oligophrenin 1 2 2
MIRT540412 PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 2 2
MIRT541200 HSP90AA1 heat shock protein 90 alpha family class A member 1 2 2
MIRT541395 CDC27 cell division cycle 27 2 2
MIRT546443 SNX5 sorting nexin 5 2 2
MIRT547369 MSI2 musashi RNA binding protein 2 2 2
MIRT553288 TSPAN3 tetraspanin 3 2 2
MIRT554402 SERP1 stress associated endoplasmic reticulum protein 1 2 2
MIRT557822 FOXN2 forkhead box N2 2 2
MIRT568530 ANP32E acidic nuclear phosphoprotein 32 family member E 2 2
MIRT569508 THYN1 thymocyte nuclear protein 1 2 2
MIRT570707 FAM69A family with sequence similarity 69 member A 2 2
MIRT608376 PIWIL2 piwi like RNA-mediated gene silencing 2 2 2
MIRT608483 NKTR natural killer cell triggering receptor 2 6
MIRT613533 TRA2B transformer 2 beta homolog 2 2
MIRT616601 ELP2 elongator acetyltransferase complex subunit 2 2 2
MIRT618166 DUSP18 dual specificity phosphatase 18 2 2
MIRT632059 CEP135 centrosomal protein 135 2 2
MIRT647379 ZDHHC23 zinc finger DHHC-type containing 23 2 2
MIRT648366 POTED POTE ankyrin domain family member D 2 2
MIRT651075 ZNF518B zinc finger protein 518B 2 4
MIRT653618 SLC30A4 solute carrier family 30 member 4 2 2
MIRT653636 SLC30A1 solute carrier family 30 member 1 2 2
MIRT654895 POU2F1 POU class 2 homeobox 1 2 2
MIRT656232 MFSD6 major facilitator superfamily domain containing 6 2 2
MIRT659880 CAPRIN1 cell cycle associated protein 1 2 2
MIRT660526 ARL4C ADP ribosylation factor like GTPase 4C 2 2
MIRT666286 SLC30A3 solute carrier family 30 member 3 2 2
MIRT686808 SNX2 sorting nexin 2 2 4
MIRT695302 TK1 thymidine kinase 1 2 2
MIRT699737 SERINC3 serine incorporator 3 2 2
MIRT700794 PIAS2 protein inhibitor of activated STAT 2 2 2
MIRT712270 PPP1CB protein phosphatase 1 catalytic subunit beta 2 2
MIRT712617 KNSTRN kinetochore localized astrin/SPAG5 binding protein 2 2
MIRT714264 RPL10A ribosomal protein L10a 2 2
MIRT715072 TMTC1 transmembrane and tetratricopeptide repeat containing 1 2 2
MIRT715386 TADA3 transcriptional adaptor 3 2 2
MIRT716397 NPAS1 neuronal PAS domain protein 1 2 2
MIRT725328 NFASC neurofascin 2 2
MIRT725503 GANAB glucosidase II alpha subunit 2 2
MIRT732913 IRAK2 interleukin 1 receptor associated kinase 2 3 0
MIRT734890 SMAD3 SMAD family member 3 3 0
MIRT737328 LINC02476 long intergenic non-protein coding RNA 2476 3 0
MIRT737544 MALAT1 metastasis associated lung adenocarcinoma transcript 1 (non-protein coding) 4 0
MIRT755545 PAK1 p21 (RAC1) activated kinase 1 3 1
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-497 Bufalin NULL 9547215 Quantitative real-time PCR colorectal cancer HCT116 cells 24375248 2014 up-regulated
miR-497 Diethylstilbestrol approved 448537 Microarray mammosphere-derived epithelial cells (MDEC) 19549897 2009 up-regulated
miR-497 Ethanol NULL 702 Quantitative real-time PCR CIE10 22141737 2012 up-regulated
miR-497 Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) NULL 8490 Microarray mouse brain 19270793 2009 up-regulated
miR-497 Reversine NULL 210332 Microarray C2C12 myoblast cells 24513286 2014 down-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-497 Tamoxifen 2733525 NSC180973 approved sensitive Low Breast Cancer cell line (MCF-7, T47D)
hsa-mir-497 Dabrafenib 44462760 NSC764134 approved sensitive cell line (A375)
hsa-mir-497 Paclitaxel 36314 NSC125973 approved resistant cell line (W1)
hsa-mir-497 Cisplatin 5460033 NSC119875 approved resistant cell line (CIS)
hsa-mir-497 Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-mir-497 Androstenedione+Letrozole sensitive cell line (MCF-7)
hsa-mir-497 Tamoxifen 2733525 NSC180973 approved sensitive cell line (MCF7)
hsa-mir-497 Cisplatin 5460033 NSC119875 approved sensitive cell line (BxPC3)
hsa-miR-497-3p Mitoxantrone 4212 NSC279836 approved sensitive High Breast Cancer cell line (BT-20, BT-474, BT-549, CAMA-1, HCC1143, HCC1395, HCC1569, HCC1806, HCC-1937, HCC1954, HCC202, HCC38, HCC70, Hs578T, MCF-7, MDA-MB-175VII, MDA-MB-231, MDA-MB-361, MDA-MB-415, MDA-MB-436, MDA-MB-468, SKBR3, T47D, UACC812, EVSA-T, MPE-600 , SK-BR-
hsa-miR-497-3p Docetaxel 148124 NSC628503 approved resistant High Breast Cancer cell line (MDA-MB-231, MCF-7)
hsa-miR-497-3p Cisplatin 5460033 NSC119875 approved resistant High Non-Small Cell Lung Cancer cell line (A549, PC-9)
hsa-miR-497-3p Cisplatin 5460033 NSC119875 approved resistant Low Non-Small Cell Lung Cancer cell line (A549)
hsa-miR-497-3p Gefitinib 123631 NSC715055 approved sensitive cell line (PC9)
hsa-miR-497-3p Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-miR-497-3p Cisplatin 5460033 NSC119875 approved resistant tissue
hsa-miR-497-3p Sunitinib 5329102 NSC750690 approved resistant tissue (CardB)
hsa-miR-497-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-497-3p Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)

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