pre-miRNA Information | |
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pre-miRNA | hsa-mir-8066 |
Genomic Coordinates | chr4: 101240795 - 101240872 |
Description | Homo sapiens miR-8066 stem-loop |
Comment | None |
RNA Secondary Structure | ![]() |
Mature miRNA Information | ||||||||||||||||||||||||||||
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Mature miRNA | hsa-miR-8066 | |||||||||||||||||||||||||||
Sequence | 48| CAAUGUGAUCUUUUGGAUGUA |68 | |||||||||||||||||||||||||||
Evidence | Experimental | |||||||||||||||||||||||||||
Experiments | Illumina | |||||||||||||||||||||||||||
SNPs in miRNA |
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Putative Targets |
Gene Information | |||||||||||||||||||||
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Gene Symbol | RFWD3 | ||||||||||||||||||||
Synonyms | FANCW, RNF201 | ||||||||||||||||||||
Description | ring finger and WD repeat domain 3 | ||||||||||||||||||||
Transcript | NM_018124 | ||||||||||||||||||||
Expression | |||||||||||||||||||||
Putative miRNA Targets on RFWD3 | |||||||||||||||||||||
3'UTR of RFWD3 (miRNA target sites are highlighted) |
>RFWD3|NM_018124|3'UTR 1 CTGTGGTCTCGAAACCTTGAAGGCATGCTGCTGGTTAGATGTTGTTTGCTAGCGCCTAGCAGCCCCAAGCAAGATCCCTG 81 TTTATTGTCTGCAGTCTAGAACATTGGGAATCATGGTTTGTTTGCATTAGTATGATTCTAGGACCCTAGGTCACTGAGAC 161 ACTACAGATTGTGTATCTGTTATGTCCACTAAAAGAGTAATTGATGGGTACTTTATCTACATTATCCATTTCTTGGGTTT 241 AAAGCCTTCATTAACCATTATTGTATGTTGGAAATTCTTATTTTCTTTATTTTCTGTGTGACTTTCTGGACCTTAGAGAG 321 TGTCCTCTCATCATCTAGGATGTGAGTGGGCATCAAGCATTTTCTGGGGAATATGACATCCCATCTGAGTTGTCCTGTCA 401 CTTAAGTATCCTTGAAGGGACTAACCATCGTCTTGGTACTGATTTGATGCAACGTAGATGTAAAAGAGTATTATTCAGTT 481 GAACACAAGAGGGCACTGTAGAACCTTGTGTCCGGTTTATTTCTGACCTTGAAGGCTGACAATCTTTTAGTAACTTGTCT 561 CATCTCCACACAAGTGTGTGATAGCACACCTGGGTGTGCTTTGTGGCAATAACACTTGTGTTCCAGGTGTGAAGTGCTGG 641 GACATTGGCAGGCCCAGTGATGGAAGCAGCTAGTGAACGATTCCCTTTGCTAATGCCTAGTGCATTAAGTTCATTGCTTT 721 GCGAAAGGTAAGGAAAGAGGCCAGTTGTTTGAGCGGTGGGGAAGATTTTGTTTTTTCTAGCCAGCTTAGGATCTCAGGAT 801 TGGTTTTATCCAAGCTAGTGCTTTGAAGAACACTATCTCTTGCCAGGAAAAGATGAGTGATAGGTCAAAGCTTTTACTTG 881 AGTCTCCCCTAGTGTCAGAGATCAGGAGAAAAGACATAAGAGAATTTACAAAAGCTATTCAGACTGCTATTGAAAACATG 961 AGAAGAACTTGTCTCCCATTTTGAGAGTTCCTATCTAAATAAAGCCAATTCCTCAGACTGAGGGGCTGTTCTTAAGTGTT 1041 CTTTATACATTCCAGTTATCCAGTTAAAGCCTTCCCCATGTGAAGCTGATGTTTGATTCCAGTTTCCTTTGATTTGCCTC 1121 CCTAACCTTTTCTAGGGCTCAGTTTGTATTTCTTTGCCTTGCCTCAGACTACTTTGCCAACCCACTTCCACAACAGAATA 1201 TGCTTCAAGATGTGGGCAGGTCAGTGTCCTGTTCATGGGAGAAAATGGCTTAACAGTCTGATTTTCTCAAATGATTATTG 1281 AAGAGTTGTTATCGTTTTTATTATAAAACACTTCTGACCTGTCAATTCAAGAGCTGTTTCTAGGATCTTTCTCTCCGGCA 1361 AGGGGTTGTTGCACTAGATTTCCCCAGAGTTCCAAGTTCTAGTTGTGCCTTTTAATGACCCTTTAATATTTTAGGACATA 1441 ATTTTTTCCTTTTTTAAATTTTTTTGTAGAAATAGATGTTTCACTACGTTGTCCAGGCTGGTCTTGGACTCCTGGCCTCA 1521 AGCAATCCTCCCACCTCAGCCTCCTAAAGTGCCAAAATTATAGGCGTGAGCCACTGCACCCGGCCCCTATTTGAAGACGT 1601 CTTTTGTAAAAGCTAGCTTCTAGAACCTGAGAAAAGCTCTTTTCTCAGAGGAGATACTCCTTTTGATATGTTAATGATTA 1681 AGAGTGGTTGCCCAGGCCTAGTTTCAGTGGCAGAATAGGATTGGAATTAAAAAGCAGAACTCATCTGGCTTCAGCAGATT 1761 GCCACCAAGAGGATACAGGTGGTCAGGTCCTGGCTGGCTTTGTCTTTGGGCCTGGGCAGGCTTAGGATTTGACTTTCTTT 1841 GAAGTACCTGATGCTGATTGATTCCACTAATAGTAGGAAGCAAGAGACTTAACTATGAGGGACGTTATGTGAATCTTAAG 1921 TCTTACCAGTCCTTGCATTAGTACATTAAATTTGGATGTTTTGGAAGCAAATTCATACGATCGTGAGTGATTTCTCCAAA 2001 GAAAAAAAGCCTTGTCCAGCCTGACCAACATGGTGAAACCCCATCTCTACTAAAAATACAAAAATTAACTGGGTGCAGTG 2081 GTGCGCATGCCTGTAGTCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATTGCTTGAACCCTGGGAGGCAGAGGTTGCAGT 2161 GAGTCGAGATCGCGCCACTGCACTCCAGCCTCGGTGACAGAGCAAGACTCCATCTCAAAAAAAACAAACAAACAAAAAAA 2241 AACCCTGATGCCATTCCCAGTCCCCGTTGTAGGACATCACATTTATAAATCCAGGCTTTAGTCTTCTGGGCTCCACCAGT 2321 CTCTGCCCCACCATATTCCTTTGTCACTACCTCTAAGTTTTTTTCCCCACTTGAGGATTTGGAGTTAAACGAACTCAAAA 2401 TGTCTTGTCATTGTATGTATTCTTGCCCCTGCTTTGAAAACAGGGCCATGGGAACTCTGTTTATGCCCTGTTTTAATGTT 2481 TCTGTTTTATGTTTTACTGTTAATATGAAAATAAAGAATTTGCTATGTA Target sites
Provided by authors
Predicted by miRanda
DRVs
SNPs
DRVs & SNPs
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miRNA-target interactions (Predicted by miRanda) |
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DRVs in gene 3'UTRs | |||||||||||||||||||||
SNPs in gene 3'UTRs |
Experimental Support 1 for Functional miRNA-Target Interaction | |
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miRNA:Target | ---- |
Validation Method |
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Conditions | Hela |
Location of target site | 3'UTR |
Tools used in this research | TargetScan , miRTarCLIP , Piranha |
Original Description (Extracted from the article) |
...
HITS-CLIP data was present in GSM1048187. RNA binding protein: AGO2. Condition:Hela_AGO2_CLIP_control
... - Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al., 2013, Cell. |
Article |
- Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al. - Cell, 2013
The induction of pluripotency or trans-differentiation of one cell type to another can be accomplished with cell-lineage-specific transcription factors. Here, we report that repression of a single RNA binding polypyrimidine-tract-binding (PTB) protein, which occurs during normal brain development via the action of miR-124, is sufficient to induce trans-differentiation of fibroblasts into functional neurons. Besides its traditional role in regulated splicing, we show that PTB has a previously undocumented function in the regulation of microRNA functions, suppressing or enhancing microRNA targeting by competitive binding on target mRNA or altering local RNA secondary structure. A key event during neuronal induction is the relief of PTB-mediated blockage of microRNA action on multiple components of the REST complex, thereby derepressing a large array of neuronal genes, including miR-124 and multiple neuronal-specific transcription factors, in nonneuronal cells. This converts a negative feedback loop to a positive one to elicit cellular reprogramming to the neuronal lineage.
LinkOut: [PMID: 23313552]
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CLIP-seq Support 1 for dataset GSM1048187 | |
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Method / RBP | HITS-CLIP / AGO2 |
Cell line / Condition | Hela / Hela_AGO2_CLIP_control |
Location of target site | ENST00000361070.4 | 3UTR | ACAUUUAUAAAUCCAGG |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 23313552 / GSE42701 |
CLIP-seq Viewer | Link |
MiRNA-Target Expression Profile | |||||||
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MiRNA-Target Expression Profile (TCGA) | |||||||
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92 hsa-miR-8066 Target Genes:
Functional analysis:
ID![]() |
Target | Description | Validation methods |
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Strong evidence | Less strong evidence | |||||||||||
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MIRT060588 | CCND1 | cyclin D1 | ![]() |
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2 | 2 | ||||||
MIRT067440 | RIMKLB | ribosomal modification protein rimK like family member B | ![]() |
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2 | 2 | ||||||
MIRT078862 | WBP2 | WW domain binding protein 2 | ![]() |
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2 | 2 | ||||||
MIRT088062 | UBXN2A | UBX domain protein 2A | ![]() |
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2 | 4 | ||||||
MIRT088214 | NUP50 | nucleoporin 50 | ![]() |
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2 | 2 | ||||||
MIRT103494 | HOXA3 | homeobox A3 | ![]() |
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2 | 8 | ||||||
MIRT135196 | TMBIM6 | transmembrane BAX inhibitor motif containing 6 | ![]() |
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2 | 4 | ||||||
MIRT177727 | REEP3 | receptor accessory protein 3 | ![]() |
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2 | 2 | ||||||
MIRT179439 | TBRG1 | transforming growth factor beta regulator 1 | ![]() |
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2 | 4 | ||||||
MIRT191647 | SLC39A9 | solute carrier family 39 member 9 | ![]() |
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2 | 2 | ||||||
MIRT192342 | KLF13 | Kruppel like factor 13 | ![]() |
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2 | 2 | ||||||
MIRT212035 | RAPGEF2 | Rap guanine nucleotide exchange factor 2 | ![]() |
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2 | 2 | ||||||
MIRT215387 | CREBRF | CREB3 regulatory factor | ![]() |
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2 | 2 | ||||||
MIRT235001 | IER2 | immediate early response 2 | ![]() |
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2 | 2 | ||||||
MIRT238793 | TPD52L1 | tumor protein D52 like 1 | ![]() |
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2 | 2 | ||||||
MIRT273384 | SMARCD1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 | ![]() |
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2 | 4 | ||||||
MIRT280473 | UBR7 | ubiquitin protein ligase E3 component n-recognin 7 (putative) | ![]() |
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2 | 2 | ||||||
MIRT298320 | SLC5A3 | solute carrier family 5 member 3 | ![]() |
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2 | 2 | ||||||
MIRT309180 | SPATA5 | spermatogenesis associated 5 | ![]() |
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2 | 2 | ||||||
MIRT354483 | LRRC58 | leucine rich repeat containing 58 | ![]() |
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2 | 2 | ||||||
MIRT354710 | SLC25A36 | solute carrier family 25 member 36 | ![]() |
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2 | 2 | ||||||
MIRT361004 | CDC5L | cell division cycle 5 like | ![]() |
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2 | 4 | ||||||
MIRT366247 | VMA21 | VMA21, vacuolar ATPase assembly factor | ![]() |
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2 | 2 | ||||||
MIRT405774 | EIF5 | eukaryotic translation initiation factor 5 | ![]() |
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2 | 2 | ||||||
MIRT442640 | TBC1D12 | TBC1 domain family member 12 | ![]() |
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2 | 2 | ||||||
MIRT443928 | ZNF99 | zinc finger protein 99 | ![]() |
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2 | 2 | ||||||
MIRT454287 | FXN | frataxin | ![]() |
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2 | 2 | ||||||
MIRT454367 | ASAH2 | N-acylsphingosine amidohydrolase 2 | ![]() |
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2 | 2 | ||||||
MIRT463574 | ZBTB39 | zinc finger and BTB domain containing 39 | ![]() |
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2 | 6 | ||||||
MIRT464484 | UGCG | UDP-glucose ceramide glucosyltransferase | ![]() |
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2 | 2 | ||||||
MIRT466866 | STX6 | syntaxin 6 | ![]() |
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2 | 2 | ||||||
MIRT467283 | SPNS1 | sphingolipid transporter 1 (putative) | ![]() |
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2 | 2 | ||||||
MIRT470298 | PPTC7 | PTC7 protein phosphatase homolog | ![]() |
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2 | 2 | ||||||
MIRT471630 | PAPD7 | poly(A) RNA polymerase D7, non-canonical | ![]() |
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2 | 2 | ||||||
MIRT472802 | MTMR4 | myotubularin related protein 4 | ![]() |
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2 | 4 | ||||||
MIRT474708 | KIF3A | kinesin family member 3A | ![]() |
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2 | 2 | ||||||
MIRT478256 | DDX3X | DEAD-box helicase 3, X-linked | ![]() |
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2 | 2 | ||||||
MIRT479330 | CERS2 | ceramide synthase 2 | ![]() |
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2 | 2 | ||||||
MIRT480658 | BSCL2 | BSCL2, seipin lipid droplet biogenesis associated | ![]() |
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2 | 2 | ||||||
MIRT481954 | ANKRD11 | ankyrin repeat domain 11 | ![]() |
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2 | 2 | ||||||
MIRT482895 | IAH1 | isoamyl acetate-hydrolyzing esterase 1 homolog | ![]() |
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2 | 4 | ||||||
MIRT493634 | HIC2 | HIC ZBTB transcriptional repressor 2 | ![]() |
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2 | 2 | ||||||
MIRT500847 | SYPL1 | synaptophysin like 1 | ![]() |
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2 | 4 | ||||||
MIRT502035 | LRIG2 | leucine rich repeats and immunoglobulin like domains 2 | ![]() |
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2 | 2 | ||||||
MIRT502185 | IGSF3 | immunoglobulin superfamily member 3 | ![]() |
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2 | 4 | ||||||
MIRT502605 | DNAJB9 | DnaJ heat shock protein family (Hsp40) member B9 | ![]() |
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2 | 10 | ||||||
MIRT502977 | CCNL1 | cyclin L1 | ![]() |
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2 | 8 | ||||||
MIRT504725 | PLEKHA6 | pleckstrin homology domain containing A6 | ![]() |
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2 | 10 | ||||||
MIRT504778 | CLEC2D | C-type lectin domain family 2 member D | ![]() |
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2 | 4 | ||||||
MIRT505786 | SATB1 | SATB homeobox 1 | ![]() |
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2 | 4 | ||||||
MIRT510090 | PPWD1 | peptidylprolyl isomerase domain and WD repeat containing 1 | ![]() |
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2 | 4 | ||||||
MIRT520010 | YY1 | YY1 transcription factor | ![]() |
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2 | 4 | ||||||
MIRT532552 | TXNL1 | thioredoxin like 1 | ![]() |
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2 | 2 | ||||||
MIRT533433 | TRPS1 | transcriptional repressor GATA binding 1 | ![]() |
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2 | 2 | ||||||
MIRT537459 | FAM84B | family with sequence similarity 84 member B | ![]() |
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2 | 2 | ||||||
MIRT541825 | SV2B | synaptic vesicle glycoprotein 2B | ![]() |
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2 | 2 | ||||||
MIRT543222 | TMEM117 | transmembrane protein 117 | ![]() |
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2 | 2 | ||||||
MIRT551088 | DDX52 | DExD-box helicase 52 | ![]() |
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2 | 2 | ||||||
MIRT551500 | UGT2B4 | UDP glucuronosyltransferase family 2 member B4 | ![]() |
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2 | 2 | ||||||
MIRT552326 | ZNF791 | zinc finger protein 791 | ![]() |
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2 | 2 | ||||||
MIRT553213 | TXLNG | taxilin gamma | ![]() |
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2 | 2 | ||||||
MIRT554590 | RRAGC | Ras related GTP binding C | ![]() |
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2 | 2 | ||||||
MIRT559004 | CA8 | carbonic anhydrase 8 | ![]() |
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2 | 2 | ||||||
MIRT559134 | BTG3 | BTG anti-proliferation factor 3 | ![]() |
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2 | 4 | ||||||
MIRT559409 | GDNF | glial cell derived neurotrophic factor | ![]() |
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2 | 4 | ||||||
MIRT560678 | SRFBP1 | serum response factor binding protein 1 | ![]() |
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2 | 2 | ||||||
MIRT560954 | POTED | POTE ankyrin domain family member D | ![]() |
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2 | 2 | ||||||
MIRT562856 | C17orf58 | chromosome 17 open reading frame 58 | ![]() |
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2 | 2 | ||||||
MIRT563003 | MOCS2 | molybdenum cofactor synthesis 2 | ![]() |
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2 | 2 | ||||||
MIRT564545 | CCDC80 | coiled-coil domain containing 80 | ![]() |
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2 | 2 | ||||||
MIRT566272 | PTAR1 | protein prenyltransferase alpha subunit repeat containing 1 | ![]() |
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2 | 2 | ||||||
MIRT566510 | PAWR | pro-apoptotic WT1 regulator | ![]() |
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2 | 2 | ||||||
MIRT572103 | EFNB2 | ephrin B2 | ![]() |
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2 | 2 | ||||||
MIRT574576 | NLGN4X | neuroligin 4, X-linked | ![]() |
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2 | 4 | ||||||
MIRT576574 | Serpine1 | serine (or cysteine) peptidase inhibitor, clade E, member 1 | ![]() |
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2 | 2 | ||||||
MIRT610815 | POT1 | protection of telomeres 1 | ![]() |
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2 | 2 | ||||||
MIRT624589 | BCL11B | B-cell CLL/lymphoma 11B | ![]() |
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2 | 2 | ||||||
MIRT627567 | SMAD6 | SMAD family member 6 | ![]() |
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2 | 2 | ||||||
MIRT632675 | MTX3 | metaxin 3 | ![]() |
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2 | 2 | ||||||
MIRT689265 | WDR83OS | WD repeat domain 83 opposite strand | ![]() |
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2 | 2 | ||||||
MIRT694310 | COPB2 | coatomer protein complex subunit beta 2 | ![]() |
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2 | 2 | ||||||
MIRT697721 | USP8 | ubiquitin specific peptidase 8 | ![]() |
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2 | 2 | ||||||
MIRT700209 | RFWD3 | ring finger and WD repeat domain 3 | ![]() |
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2 | 2 | ||||||
MIRT704399 | CTSS | cathepsin S | ![]() |
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2 | 2 | ||||||
MIRT710665 | CSTF2T | cleavage stimulation factor subunit 2 tau variant | ![]() |
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2 | 2 | ||||||
MIRT711953 | SLC7A14 | solute carrier family 7 member 14 | ![]() |
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2 | 2 | ||||||
MIRT712596 | ADCYAP1 | adenylate cyclase activating polypeptide 1 | ![]() |
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2 | 2 | ||||||
MIRT712692 | TNFAIP2 | TNF alpha induced protein 2 | ![]() |
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2 | 2 | ||||||
MIRT714171 | PPP1R2 | protein phosphatase 1 regulatory inhibitor subunit 2 | ![]() |
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2 | 2 | ||||||
MIRT715964 | CES4A | carboxylesterase 4A | ![]() |
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2 | 2 | ||||||
MIRT722781 | PDE3A | phosphodiesterase 3A | ![]() |
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2 | 2 | ||||||
MIRT724505 | MSMO1 | methylsterol monooxygenase 1 | ![]() |
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2 | 2 |