pre-miRNA Information
pre-miRNA hsa-mir-6787   
Genomic Coordinates chr17: 82236668 - 82236728
Description Homo sapiens miR-6787 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-6787-5p
Sequence 6| UGGCGGGGGUAGAGCUGGCUGC |27
Evidence Experimental
Experiments Meta-analysis
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs778888046 4 dbSNP
rs772018061 5 dbSNP
rs760886644 6 dbSNP
rs776925052 7 dbSNP
rs760060985 8 dbSNP
rs1432528063 9 dbSNP
rs778772390 10 dbSNP
rs924024166 11 dbSNP
rs201523090 13 dbSNP
rs1451075810 17 dbSNP
rs1378844609 18 dbSNP
Putative Targets

Gene Information
Gene Symbol PRSS22   
Synonyms BSSP-4, SP001LA, hBSSP-4
Description protease, serine 22
Transcript NM_022119   
Expression
Putative miRNA Targets on PRSS22
3'UTR of PRSS22
(miRNA target sites are highlighted)
>PRSS22|NM_022119|3'UTR
   1 GGCGCAGCGGGACGCGGGGCTCGGATCTGAAAGGCGGCCAGATCCACATCTGGATCTGGATCTGCGGCGGCCTCGGGCGG
  81 TTTCCCCCGCCGTAAATAGGCTCATCTACCTCTACCTCTGGGGGCCCGGACGGCTGCTGCGGAAAGGAAACCCCCTCCCC
 161 GACCCGCCCGACGGCCTCAGGCCCCGCCTCCAAGGCATCAGGCCCCGCCCAACGGCCTCATGTCCCCGCCCCCACGACTT
 241 CCGGCCCCGCCCCGGGCCCCAGCGCTTTTGTGTATATAAATGTTAATGATTTTTATAGGTATTTGTAACCCTGCCCACAT
 321 ATCTTATTTATTCCTCCAATTTCAATAAATTATTTATTCTCCAGTGAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' cgucgGUC-GAG-AUGGGGGCGGu 5'
               |:| ||| |::||||||| 
Target 5' cccaaCGGCCTCATGTCCCCGCCc 3'
208 - 231 157.00 -26.30
2
miRNA  3' cgUCGGUCGAGAUGGGGGCGGu 5'
            :| |:|:|:  |||||||| 
Target 5' tcGGGCGGTTT--CCCCCGCCg 3'
73 - 92 156.00 -30.10
3
miRNA  3' cguCGGUC-GAGAUGGGGGCGGu 5'
             | |:| ||| : ||||||| 
Target 5' cccGACGGCCTCAGGCCCCGCCt 3'
167 - 189 155.00 -24.10
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN13664430 2 COSMIC
COSN20078659 4 COSMIC
COSN26990576 8 COSMIC
COSN19689886 13 COSMIC
COSN26600286 47 COSMIC
COSN32051638 83 COSMIC
COSN7303886 87 COSMIC
COSN32061903 105 COSMIC
COSN20078556 150 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs374155905 2 dbSNP
rs766283168 3 dbSNP
rs1171015577 4 dbSNP
rs1465757883 8 dbSNP
rs1391099209 9 dbSNP
rs762821444 11 dbSNP
rs3743944 13 dbSNP
rs1247941764 14 dbSNP
rs1004002050 15 dbSNP
rs1188897471 16 dbSNP
rs1035568261 17 dbSNP
rs1257681470 18 dbSNP
rs1198334841 23 dbSNP
rs769619975 24 dbSNP
rs1275019381 25 dbSNP
rs113609771 26 dbSNP
rs1339885699 27 dbSNP
rs1296742773 32 dbSNP
rs1296277099 33 dbSNP
rs776322810 35 dbSNP
rs1342300436 36 dbSNP
rs1332277226 37 dbSNP
rs768149243 38 dbSNP
rs746461644 39 dbSNP
rs1170788839 41 dbSNP
rs1428181639 44 dbSNP
rs774871391 45 dbSNP
rs771417171 46 dbSNP
rs1054912 47 dbSNP
rs1026873984 56 dbSNP
rs1244409696 67 dbSNP
rs1374475737 68 dbSNP
rs905459091 74 dbSNP
rs1281203152 75 dbSNP
rs1045372839 76 dbSNP
rs1238536934 78 dbSNP
rs949652583 79 dbSNP
rs1001874520 83 dbSNP
rs896526390 84 dbSNP
rs1320955213 88 dbSNP
rs567647396 89 dbSNP
rs896849786 90 dbSNP
rs1263286727 100 dbSNP
rs935435444 107 dbSNP
rs1368765433 108 dbSNP
rs112828262 110 dbSNP
rs1446244674 114 dbSNP
rs59921428 120 dbSNP
rs68162639 120 dbSNP
rs925318392 125 dbSNP
rs978581900 127 dbSNP
rs1179323453 130 dbSNP
rs1395604629 131 dbSNP
rs1335121139 133 dbSNP
rs1470776051 139 dbSNP
rs947193639 140 dbSNP
rs1309044498 142 dbSNP
rs1196820881 150 dbSNP
rs1490872958 151 dbSNP
rs921083489 152 dbSNP
rs1292779135 154 dbSNP
rs1216240392 155 dbSNP
rs898126480 156 dbSNP
rs1342274089 160 dbSNP
rs1256454426 161 dbSNP
rs943837723 165 dbSNP
rs1176520237 166 dbSNP
rs1286009006 167 dbSNP
rs1224147283 168 dbSNP
rs1161209823 169 dbSNP
rs1366786469 173 dbSNP
rs890869528 175 dbSNP
rs1273045731 176 dbSNP
rs1406240022 186 dbSNP
rs1345656205 188 dbSNP
rs1378112742 189 dbSNP
rs1299843436 194 dbSNP
rs1297055492 195 dbSNP
rs1051942500 197 dbSNP
rs1325224674 201 dbSNP
rs1196444143 205 dbSNP
rs1346632473 207 dbSNP
rs1178831006 211 dbSNP
rs1265221646 212 dbSNP
rs975324330 215 dbSNP
rs1432566151 217 dbSNP
rs932119160 220 dbSNP
rs1431619341 222 dbSNP
rs1476963286 228 dbSNP
rs1161671945 234 dbSNP
rs1170250644 234 dbSNP
rs965670731 235 dbSNP
rs1019285824 236 dbSNP
rs1387918803 239 dbSNP
rs547683456 240 dbSNP
rs767231289 247 dbSNP
rs1346852190 249 dbSNP
rs1216351443 251 dbSNP
rs57392867 254 dbSNP
rs759148792 254 dbSNP
rs1401703116 257 dbSNP
rs1425046515 259 dbSNP
rs979005246 260 dbSNP
rs1481453669 261 dbSNP
rs12786 262 dbSNP
rs951180848 264 dbSNP
rs1430570026 266 dbSNP
rs1163105438 269 dbSNP
rs1026706587 274 dbSNP
rs995244743 275 dbSNP
rs1193051335 277 dbSNP
rs913264211 283 dbSNP
rs989214647 286 dbSNP
rs960153003 287 dbSNP
rs905386827 288 dbSNP
rs1487401004 294 dbSNP
rs1297088162 296 dbSNP
rs376993757 298 dbSNP
rs527898507 322 dbSNP
rs568412514 323 dbSNP
rs1216199165 328 dbSNP
rs1320897820 334 dbSNP
rs373862640 336 dbSNP
rs1293897127 337 dbSNP
rs1487288303 339 dbSNP
rs1337679273 350 dbSNP
rs1215953893 359 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions Hela
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1048187. RNA binding protein: AGO2. Condition:Hela_AGO2_CLIP_control ...

- Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al., 2013, Cell.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' cgucggucgagAUGGGGGCGGu 5'
                     | |||||||| 
Target 5' -----------UUCCCCCGCCg 3'
1 - 11
Article - Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al.
- Cell, 2013
The induction of pluripotency or trans-differentiation of one cell type to another can be accomplished with cell-lineage-specific transcription factors. Here, we report that repression of a single RNA binding polypyrimidine-tract-binding (PTB) protein, which occurs during normal brain development via the action of miR-124, is sufficient to induce trans-differentiation of fibroblasts into functional neurons. Besides its traditional role in regulated splicing, we show that PTB has a previously undocumented function in the regulation of microRNA functions, suppressing or enhancing microRNA targeting by competitive binding on target mRNA or altering local RNA secondary structure. A key event during neuronal induction is the relief of PTB-mediated blockage of microRNA action on multiple components of the REST complex, thereby derepressing a large array of neuronal genes, including miR-124 and multiple neuronal-specific transcription factors, in nonneuronal cells. This converts a negative feedback loop to a positive one to elicit cellular reprogramming to the neuronal lineage.
LinkOut: [PMID: 23313552]
CLIP-seq Support 1 for dataset GSM1048187
Method / RBP HITS-CLIP / AGO2
Cell line / Condition Hela / Hela_AGO2_CLIP_control
Location of target site ENST00000161006.3 | 3UTR | UUCCCCCGCCGUAAAUAGGCUCAUCUACCUCUA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23313552 / GSE42701
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
90 hsa-miR-6787-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT449091 XPO6 exportin 6 2 2
MIRT449991 PSMG1 proteasome assembly chaperone 1 2 2
MIRT454608 MYADM myeloid associated differentiation marker 2 2
MIRT456116 VAV3 vav guanine nucleotide exchange factor 3 2 6
MIRT457064 TOR4A torsin family 4 member A 2 2
MIRT461023 SDF4 stromal cell derived factor 4 2 2
MIRT467197 SPRY4 sprouty RTK signaling antagonist 4 2 2
MIRT471711 OTUB1 OTU deubiquitinase, ubiquitin aldehyde binding 1 2 2
MIRT472566 NACC1 nucleus accumbens associated 1 2 2
MIRT476079 GRB2 growth factor receptor bound protein 2 2 2
MIRT480150 CALR calreticulin 2 2
MIRT483027 KHSRP KH-type splicing regulatory protein 2 4
MIRT483498 STMN3 stathmin 3 2 4
MIRT483728 THSD4 thrombospondin type 1 domain containing 4 2 2
MIRT484550 BARHL1 BarH like homeobox 1 2 6
MIRT484684 PACSIN1 protein kinase C and casein kinase substrate in neurons 1 2 2
MIRT486059 CTDNEP1 CTD nuclear envelope phosphatase 1 2 2
MIRT486116 INO80E INO80 complex subunit E 2 2
MIRT486313 SIPA1 signal-induced proliferation-associated 1 2 2
MIRT486525 CLCN7 chloride voltage-gated channel 7 2 2
MIRT486857 DPF1 double PHD fingers 1 2 2
MIRT487352 PHF15 jade family PHD finger 2 1 1
MIRT487582 FAM83H family with sequence similarity 83 member H 2 4
MIRT487792 GPR20 G protein-coupled receptor 20 2 4
MIRT488104 POU3F1 POU class 3 homeobox 1 2 2
MIRT488786 POFUT2 protein O-fucosyltransferase 2 2 2
MIRT489361 SYNGR1 synaptogyrin 1 2 4
MIRT489387 RAB11B RAB11B, member RAS oncogene family 2 2
MIRT489680 SCAMP4 secretory carrier membrane protein 4 2 2
MIRT489731 GNAI2 G protein subunit alpha i2 2 4
MIRT489750 TACC3 transforming acidic coiled-coil containing protein 3 2 2
MIRT490029 PCSK4 proprotein convertase subtilisin/kexin type 4 2 2
MIRT490379 LHFPL3 LHFPL tetraspan subfamily member 3 2 2
MIRT490580 SLC47A1 solute carrier family 47 member 1 2 2
MIRT490753 SRCIN1 SRC kinase signaling inhibitor 1 2 2
MIRT491187 JUND JunD proto-oncogene, AP-1 transcription factor subunit 2 4
MIRT491301 VGF VGF nerve growth factor inducible 2 2
MIRT491462 HOXB8 homeobox B8 2 2
MIRT491702 PDZD4 PDZ domain containing 4 2 2
MIRT491724 RTN4R reticulon 4 receptor 2 2
MIRT491737 SEMA3F semaphorin 3F 2 2
MIRT491984 UNK unkempt family zinc finger 2 2
MIRT492844 NRGN neurogranin 2 2
MIRT492936 NEUROD2 neuronal differentiation 2 2 4
MIRT493713 H2AFX H2A histone family member X 2 2
MIRT494623 ASB6 ankyrin repeat and SOCS box containing 6 2 4
MIRT494703 ARHGAP31 Rho GTPase activating protein 31 2 2
MIRT495602 NKX2-5 NK2 homeobox 5 2 2
MIRT495750 PDE4C phosphodiesterase 4C 2 4
MIRT500367 ZNF385A zinc finger protein 385A 2 2
MIRT501161 SLC10A7 solute carrier family 10 member 7 2 6
MIRT501702 PCGF3 polycomb group ring finger 3 2 6
MIRT504922 PDRG1 p53 and DNA damage regulated 1 2 2
MIRT517945 TRIM59 tripartite motif containing 59 2 2
MIRT524212 DDI2 DNA damage inducible 1 homolog 2 2 6
MIRT531186 SIGLEC12 sialic acid binding Ig like lectin 12 (gene/pseudogene) 2 2
MIRT531972 C12orf49 chromosome 12 open reading frame 49 2 2
MIRT558055 EVI5L ecotropic viral integration site 5 like 2 2
MIRT560482 LACE1 AFG1 like ATPase 2 2
MIRT563217 FXN frataxin 2 2
MIRT569095 FSCN1 fascin actin-bundling protein 1 2 2
MIRT569522 AP5Z1 adaptor related protein complex 5 zeta 1 subunit 2 2
MIRT569531 CTTN cortactin 2 2
MIRT569848 RGS5 regulator of G protein signaling 5 2 2
MIRT570738 ANKRD52 ankyrin repeat domain 52 2 2
MIRT574140 MARVELD1 MARVEL domain containing 1 2 2
MIRT615994 DHTKD1 dehydrogenase E1 and transketolase domain containing 1 2 2
MIRT628493 ZNF556 zinc finger protein 556 2 2
MIRT633451 KLLN killin, p53-regulated DNA replication inhibitor 2 2
MIRT649054 SLC1A2 solute carrier family 1 member 2 2 2
MIRT649340 HEXA hexosaminidase subunit alpha 2 2
MIRT670226 PTCHD1 patched domain containing 1 2 2
MIRT670666 KIAA1551 KIAA1551 2 2
MIRT671452 CDH7 cadherin 7 2 2
MIRT671729 ZNF451 zinc finger protein 451 2 2
MIRT690285 ZNF154 zinc finger protein 154 2 2
MIRT700575 PRSS22 protease, serine 22 2 2
MIRT701411 NKRF NFKB repressing factor 2 2
MIRT711877 VASP vasodilator stimulated phosphoprotein 2 2
MIRT712082 UNC13A unc-13 homolog A 2 2
MIRT712523 CYTH2 cytohesin 2 2 2
MIRT712751 GMDS GDP-mannose 4,6-dehydratase 2 2
MIRT714681 PRX periaxin 2 2
MIRT714718 VPS8 VPS8, CORVET complex subunit 2 2
MIRT717508 HRNR hornerin 2 2
MIRT717650 THBS2 thrombospondin 2 2 2
MIRT719592 PIAS4 protein inhibitor of activated STAT 4 2 2
MIRT720521 PTGR2 prostaglandin reductase 2 2 2
MIRT721295 C3orf36 chromosome 3 open reading frame 36 2 2
MIRT724922 VPS18 VPS18, CORVET/HOPS core subunit 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-6787 Ceritinib 57379345 NSC776422 approved sensitive High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-miR-6787-5p Dabrafenib 44462760 NSC764134 approved resistant High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-6787-5p Vemurafenib 42611257 NSC761431 approved resistant High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-6787-5p Cisplatin 5460033 NSC119875 approved sensitive cell line
hsa-miR-6787-5p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-6787-5p Tamoxifen 2733525 NSC180973 approved sensitive cell line (LCC2)
hsa-miR-6787-5p Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)
hsa-miR-6787-5p Paclitaxel 36314 NSC125973 approved resistant cell line (A2780)
hsa-miR-6787-5p Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)
hsa-miR-6787-5p Docetaxel+Cisplatin+5-Fluorouracil resistant tissue (hypopharyngeal squamous cell carcinoma)

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