miRTarBase - #MIRT700888


—
pre-miRNA Information
pre-miRNA hsa-mir-4540   
Genomic Coordinates chr9: 36864254 - 36864308
Description Homo sapiens miR-4540 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4540
Sequence 35| UUAGUCCUGCCUGUAGGUUUA |55
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs937122950 4 dbSNP
rs143699849 7 dbSNP
Putative Targets

Gene Information
Gene Symbol PER2   
Synonyms FASPS, FASPS1
Description period circadian clock 2
Transcript NM_022817   
Expression
Putative miRNA Targets on PER2
3'UTR of PER2
(miRNA target sites are highlighted)		 
>PER2|NM_022817|3'UTR
   1 CCCCTGCCCCACCTCAGCCCGGCAGCCAGCGAGGTACACCAGGTGGTGCTTGGAAGAGATGAAAGATCTTCATGGCTGTT
  81 TCCACTGAAATGGACACATATGCTCATGTTGCTTTTTTTGTTTTAGAAAAAAAAACAACATAGTTTTCTGAAGGGGCGAC
 161 TTAAAACTGTGGAGAGTGGGGAGAGTTCGGAAAGAAATATGTTTTTATATATAAAATATATATGTGGAGTTTTGTGGGAT
 241 GGGGAAGAGATTTTAGTTGTTATTTAACTTGAGAAAGACTAAGCGCCTCTTAGTGTCAGGGAAGTTGCCTCAGTGCTCCC
 321 AGAAGTCCTGTGACTGTGACGAGACCTCTGTCTGCTGCACCAGCTGGGGACTCTGGCTTCCAGAGCTTTCCCAGGGTGTT
 401 TGGATCAGATCAAATTTTGTCCTCTCTTGGGGACTGCTTTTTATCTGAATTATCATTTAGTCAAGGTAGAGTGTTTTTTT
 481 ATACATACCAAATGGAGATAGCAGCCTCTCCTAGTTTTATTTCAAAACGTTTCACATTAAATGGTGTGAAGCGTTGTTTG
 561 GCAAACCAACAGCTTTGGCTTCTGGTGTGGTCAATATTTCAGTCTGACATAGGTTTTGTTTGTAGTGAACAAAGTTGAAA
 641 CATTTGCTCTGGACTAAAGAAGCCTAGTGGTTTGTGTGGCCAACTCCATCGGATGAATGCACACGCAGACAGACCCTCTG
 721 TATATTTCTGCATTATTCTTGTCTCCTTTTCAGACCATGATGGCCAATATGGAGATTAAAATATGTCATCAGTCATCTCT
 801 TTATGGTGACTTCCCTTTGCAAACCAGGCTGTGACCAACACATGTGAGACCCAGTCCTGTTTGGTTTTCTTCCGTTGGAA
 881 CCACCCAGACATCTGCTTCCACCCAGCCAAGCCCACATCACATCTCCTGGCCGAGAGCAGCCACTGCCACTCAGTCTGAC
 961 AGCTTGCGACTGCATCTGTATTTTCAGGGGTGCAGTGAGCTCACCTCTCCCACTGCACCCTGGGTTGGGTGCACAGCCCT
1041 CATTCTTTTCATGAGCCCGACCTCTCTCGGAGCAGCTTCAGGCCTCTGCCAGTGTCCCCAGCACTTTTAGGTCATTTGGA
1121 CACTTGGGGAAAAGTGAGGCCAGTCTGCCCGGCTTTTTACAAAACCTCATGTTGCATTGTATATTCCAAAGATGGTTCAG
1201 AAAATTTAATATTGGTCCCTGGTGGAAATTCAAAGTTATCACTGAAGAACAGTTGACTTAAAATTGGACCAAGACTATGA
1281 GGCTTAAAAGGGACCAGGGTTTTCTTTTTTTTTTTTTTTTTTTTTTTTTTTTAGATGGAGTTTCTTTTTGCCCAGGCTGG
1361 AGTGCAGTGGCGCCATCTTGGCTCACTGCAACCTCTGCCTCCCAGGTTCAAGCGATTCTCCTGCCTCAGCCTCCTGAGTA
1441 GCTGGGACCACAGGCGACTGCCACCACACCCAGCTAATTTTTTGTATTTTTAGTAGAGACAGGGTTTCACCATGTTGGCC
1521 AGGCTGGTCTCGAACTCCTGACCTCAAGCGATCCACCCACCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCAC
1601 CACGCCCAACTGGGACCAGGGTTTTCTGTTTTTTGATGGAGGTGAAATCTCTTTGTAATCCACTAGGTTTTCATCGTAAA
1681 ACCATCTTATGCCTGACTATTAAACCTATTCTTCATAAACACAAGAACACTTTAATTTTTCGTTAATTTACAAAGTAACA
1761 TCAGCTGCCTATGCCTATGATAAGGTAGCAGTCTGCATTCTTATGGCCATTAGATGTTACAAACTCCTTGCCTCTAAAGT
1841 CAGATCATGAAGGGATAGGTGTTCATCTAAGGTTACAGTTATGTTACCGAAACACAAAACTGCCAAAATCTTACTCTGCT
1921 GTTATGAATGTTTACCATCAGCATTATTTTATCATTTAATATGTGCTCACTGATTGTTAACTGTAGCTTCAGCGCGTGCC
2001 AAGCAGTTGACTTAATAGGATCATCTTGTGAATTTGTTTACGTGATGCCAAGCATCAAGTCATGTTTTCTTTAGTGTGTG
2081 TGCTTACACAGGTGTTAAACAGTTTTTCTCTATTTTAAACTGAGCCTTCTTTTTAATATATTCCCGAAGAGATATGTAAA
2161 TAAGCTCTCAGAGTTTCTGTGATGATTTGTTGAGCCTTGCTGGACAAGTGGTTTGTTTGTGTGCAAACCAAACTTTCTTT
2241 ACCCAGTGCAATAGATTTGTTTGACTGCTTGTGTCTTTTTATGACCTGTTTGCCTTTTAGAAAATTGGTAAATAAAGCAA
2321 GTATATTTTTATTTTTA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' auUUGGAUGU---CC--GUCCUGAUu 5'
            :||:|| |   ||  || ||||| 
Target 5' ttGACTTAAAATTGGACCAAGACTAt 3'
 1253 - 1278 125.00 -8.00
2 
miRNA  3' auUUGGAUGUCCGUCCUGAUu 5'
            ||| | ::  | |||||| 
Target 5' gaAACATTTGCTCTGGACTAa 3'
 637 - 657 123.00 -11.20
3 
miRNA  3' auUUGGAUGUCCGUCCUGAUu 5'
            |||:|: | | | ||||| 
Target 5' ttAACTTG-A-GAAAGACTAa 3'
 264 - 282 121.00 -8.00
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30177533 3 COSMIC
COSN20047204 7 COSMIC
COSN29468560 18 COSMIC
COSN30171641 104 COSMIC
COSN31581570 126 COSMIC
COSN31514567 189 COSMIC
COSN8991256 243 COSMIC
COSN18794475 813 COSMIC
COSN17076426 1005 COSMIC
COSN17076427 1010 COSMIC
COSN24036399 1034 COSMIC
COSN17076428 1039 COSMIC
COSN20098005 1304 COSMIC
COSN6175838 1779 COSMIC
COSN22188164 1782 COSMIC
COSN30158196 2004 COSMIC
COSN28390861 2041 COSMIC
COSN17182954 2078 COSMIC
COSN26188999 2127 COSMIC
COSN31479719 2169 COSMIC
COSN31489902 2169 COSMIC
COSN31550456 2184 COSMIC
rs80261926 2146 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs769994015 1 dbSNP
rs760672398 2 dbSNP
rs781492589 2 dbSNP
rs1247426253 3 dbSNP
rs1362150091 5 dbSNP
rs757784043 7 dbSNP
rs1304045671 8 dbSNP
rs747292230 9 dbSNP
rs979163957 10 dbSNP
rs1332963510 11 dbSNP
rs916555139 13 dbSNP
rs778129323 15 dbSNP
rs758811895 17 dbSNP
rs372564023 20 dbSNP
rs755605691 21 dbSNP
rs1032254511 24 dbSNP
rs749956240 26 dbSNP
rs372988688 30 dbSNP
rs1453890648 31 dbSNP
rs761833629 33 dbSNP
rs1028281461 37 dbSNP
rs1179199467 43 dbSNP
rs966552705 45 dbSNP
rs1030609497 48 dbSNP
rs369936636 51 dbSNP
rs964476487 59 dbSNP
rs1371615964 68 dbSNP
rs10181662 72 dbSNP
rs1283618106 73 dbSNP
rs942111907 74 dbSNP
rs1215992496 76 dbSNP
rs1264384115 77 dbSNP
rs761718970 81 dbSNP
rs562978975 82 dbSNP
rs544396818 83 dbSNP
rs573824197 88 dbSNP
rs536228012 99 dbSNP
rs1047913605 107 dbSNP
rs949570204 112 dbSNP
rs566966877 120 dbSNP
rs1421743764 126 dbSNP
rs991095267 126 dbSNP
rs897290847 131 dbSNP
rs1047017165 133 dbSNP
rs1326629261 136 dbSNP
rs966418767 136 dbSNP
rs979088669 136 dbSNP
rs1166310031 137 dbSNP
rs1224014750 141 dbSNP
rs1375204520 141 dbSNP
rs531061658 143 dbSNP
rs867506073 148 dbSNP
rs1020692454 153 dbSNP
rs1475221128 156 dbSNP
rs949430246 157 dbSNP
rs986594943 158 dbSNP
rs759120200 160 dbSNP
rs1055173028 163 dbSNP
rs751770732 172 dbSNP
rs936674514 172 dbSNP
rs1028626939 179 dbSNP
rs1484962084 180 dbSNP
rs925302047 181 dbSNP
rs996791349 185 dbSNP
rs540295950 188 dbSNP
rs1205244347 189 dbSNP
rs1165824552 193 dbSNP
rs1422937702 194 dbSNP
rs1465044464 196 dbSNP
rs773939497 207 dbSNP
rs1016254380 209 dbSNP
rs1356183127 211 dbSNP
rs1006255568 219 dbSNP
rs1270304444 220 dbSNP
rs773987105 222 dbSNP
rs923105801 223 dbSNP
rs1356665294 224 dbSNP
rs1234679750 232 dbSNP
rs1293373820 234 dbSNP
rs1316707618 240 dbSNP
rs1217364681 250 dbSNP
rs1285709931 261 dbSNP
rs1231289313 264 dbSNP
rs1354741592 269 dbSNP
rs1308489639 275 dbSNP
rs975917066 284 dbSNP
rs573178304 285 dbSNP
rs1411599752 287 dbSNP
rs1484367871 296 dbSNP
rs1017362161 299 dbSNP
rs558092297 301 dbSNP
rs10181401 302 dbSNP
rs896665406 316 dbSNP
rs1421646201 318 dbSNP
rs1409573738 320 dbSNP
rs1175104835 327 dbSNP
rs753591008 329 dbSNP
rs1416274429 339 dbSNP
rs1055761098 340 dbSNP
rs187979399 341 dbSNP
rs925552303 344 dbSNP
rs1271430334 362 dbSNP
rs1340757426 365 dbSNP
rs1219098402 368 dbSNP
rs994404664 369 dbSNP
rs1276953226 375 dbSNP
rs556906779 376 dbSNP
rs897400407 395 dbSNP
rs945081669 396 dbSNP
rs913616860 398 dbSNP
rs1487427175 404 dbSNP
rs149923742 406 dbSNP
rs1013697234 413 dbSNP
rs568229120 418 dbSNP
rs185011361 430 dbSNP
rs1190510350 432 dbSNP
rs975676761 450 dbSNP
rs962646477 452 dbSNP
rs1174000787 453 dbSNP
rs1359581154 454 dbSNP
rs1481926556 460 dbSNP
rs1230649778 473 dbSNP
rs1326434522 474 dbSNP
rs34195482 481 dbSNP
rs546741922 485 dbSNP
rs766149071 486 dbSNP
rs1436433829 495 dbSNP
rs1016896282 500 dbSNP
rs1451807612 514 dbSNP
rs192462890 521 dbSNP
rs936789272 523 dbSNP
rs1333805736 528 dbSNP
rs570359671 529 dbSNP
rs1358272830 533 dbSNP
rs1451056513 535 dbSNP
rs1042801193 537 dbSNP
rs1013688671 546 dbSNP
rs552139488 553 dbSNP
rs1288772111 559 dbSNP
rs896584525 563 dbSNP
rs28391755 567 dbSNP
rs976034921 570 dbSNP
rs1159898453 572 dbSNP
rs1371144721 584 dbSNP
rs1404284825 585 dbSNP
rs188019851 594 dbSNP
rs1397392221 596 dbSNP
rs1441635848 621 dbSNP
rs904108845 625 dbSNP
rs910416277 627 dbSNP
rs1241472769 630 dbSNP
rs984510041 643 dbSNP
rs182553604 649 dbSNP
rs1328092018 652 dbSNP
rs1460094246 663 dbSNP
rs1025938034 665 dbSNP
rs972146734 669 dbSNP
rs1275115741 681 dbSNP
rs529461726 683 dbSNP
rs1469777927 690 dbSNP
rs971119082 691 dbSNP
rs139794176 696 dbSNP
rs933737693 697 dbSNP
rs1364081313 701 dbSNP
rs540338987 702 dbSNP
rs191440490 704 dbSNP
rs1406497762 710 dbSNP
rs1160962009 712 dbSNP
rs1176120493 715 dbSNP
rs781746114 716 dbSNP
rs1254350566 717 dbSNP
rs1211381258 726 dbSNP
rs1467776328 728 dbSNP
rs150630785 730 dbSNP
rs1398705471 738 dbSNP
rs1033825122 748 dbSNP
rs1000882688 750 dbSNP
rs547034369 755 dbSNP
rs903939074 758 dbSNP
rs1042358990 759 dbSNP
rs1268492883 762 dbSNP
rs1295208691 767 dbSNP
rs909765763 769 dbSNP
rs982707706 781 dbSNP
rs564372771 783 dbSNP
rs1283552800 784 dbSNP
rs1337361711 795 dbSNP
rs1219743628 798 dbSNP
rs950672294 802 dbSNP
rs1441490113 810 dbSNP
rs1026299768 816 dbSNP
rs1259027654 825 dbSNP
rs546159065 827 dbSNP
rs901865637 834 dbSNP
rs201144790 844 dbSNP
rs1169309288 846 dbSNP
rs1371922368 863 dbSNP
rs1040301621 873 dbSNP
rs533618820 874 dbSNP
rs377183778 883 dbSNP
rs1394541375 885 dbSNP
rs1034217508 893 dbSNP
rs1002335859 904 dbSNP
rs1399547123 911 dbSNP
rs62194934 915 dbSNP
rs943280270 922 dbSNP
rs1276368604 926 dbSNP
rs1324631904 929 dbSNP
rs62194933 929 dbSNP
rs910363917 932 dbSNP
rs984622588 933 dbSNP
rs1343809386 938 dbSNP
rs1208432928 945 dbSNP
rs1009794243 960 dbSNP
rs771308581 967 dbSNP
rs557310421 968 dbSNP
rs933686132 972 dbSNP
rs899578532 978 dbSNP
rs187828942 986 dbSNP
rs201970111 988 dbSNP
rs1376355304 995 dbSNP
rs1419265705 997 dbSNP
rs971876553 998 dbSNP
rs971453336 1004 dbSNP
rs1383870312 1007 dbSNP
rs182946457 1012 dbSNP
rs909734723 1015 dbSNP
rs992343008 1017 dbSNP
rs1305345396 1019 dbSNP
rs1453400269 1023 dbSNP
rs1248315099 1027 dbSNP
rs571355389 1031 dbSNP
rs1258468772 1033 dbSNP
rs553160876 1038 dbSNP
rs1484730413 1042 dbSNP
rs1267318959 1045 dbSNP
rs929862550 1049 dbSNP
rs917202843 1055 dbSNP
rs531024886 1058 dbSNP
rs1350016545 1059 dbSNP
rs1282541227 1061 dbSNP
rs1001450008 1063 dbSNP
rs904055876 1065 dbSNP
rs534746856 1066 dbSNP
rs56386336 1068 dbSNP
rs548277573 1069 dbSNP
rs1298519819 1071 dbSNP
rs1393722449 1079 dbSNP
rs1009682704 1080 dbSNP
rs755603841 1084 dbSNP
rs190397394 1090 dbSNP
rs1288685381 1094 dbSNP
rs943226267 1098 dbSNP
rs889042851 1100 dbSNP
rs1239006047 1102 dbSNP
rs377518375 1105 dbSNP
rs930468521 1114 dbSNP
rs1318319460 1124 dbSNP
rs1009720671 1126 dbSNP
rs1264289578 1130 dbSNP
rs1467529983 1139 dbSNP
rs749879928 1140 dbSNP
rs972213717 1143 dbSNP
rs1175812861 1148 dbSNP
rs949845241 1150 dbSNP
rs916893607 1151 dbSNP
rs899508963 1170 dbSNP
rs569515465 1177 dbSNP
rs1415689786 1179 dbSNP
rs1459842148 1181 dbSNP
rs1327780924 1187 dbSNP
rs991117977 1189 dbSNP
rs1441260444 1195 dbSNP
rs1296239112 1197 dbSNP
rs1375088422 1199 dbSNP
rs941070511 1205 dbSNP
rs1292168279 1206 dbSNP
rs1331967305 1215 dbSNP
rs1260740426 1217 dbSNP
rs1274391750 1221 dbSNP
rs1317833954 1235 dbSNP
rs888226461 1246 dbSNP
rs185782210 1248 dbSNP
rs35093813 1251 dbSNP
rs1255405252 1263 dbSNP
rs1181461274 1264 dbSNP
rs181992615 1273 dbSNP
rs1255525743 1276 dbSNP
rs979748924 1277 dbSNP
rs118094777 1278 dbSNP
rs1409290674 1279 dbSNP
rs1447267856 1284 dbSNP
rs1168063837 1286 dbSNP
rs1021135216 1289 dbSNP
rs1462197863 1291 dbSNP
rs559362199 1292 dbSNP
rs1251989912 1296 dbSNP
rs1229831892 1298 dbSNP
rs1306021328 1299 dbSNP
rs1353142736 1299 dbSNP
rs1416158167 1301 dbSNP
rs201968989 1304 dbSNP
rs71043120 1304 dbSNP
rs34391080 1305 dbSNP
rs369910850 1305 dbSNP
rs1275592409 1306 dbSNP
rs1357909648 1306 dbSNP
rs1311518958 1307 dbSNP
rs966120184 1307 dbSNP
rs1209828337 1309 dbSNP
rs1486775196 1310 dbSNP
rs993160095 1310 dbSNP
rs1018920762 1311 dbSNP
rs1188822223 1312 dbSNP
rs1414721419 1312 dbSNP
rs1262480026 1314 dbSNP
rs1261373465 1315 dbSNP
rs1184657549 1317 dbSNP
rs939339364 1319 dbSNP
rs1172774975 1321 dbSNP
rs1373296981 1322 dbSNP
rs1299427084 1327 dbSNP
rs1460135002 1328 dbSNP
rs1372209005 1331 dbSNP
rs1192785356 1333 dbSNP
rs1192988110 1333 dbSNP
rs1211814255 1333 dbSNP
rs1218001714 1333 dbSNP
rs1234106116 1333 dbSNP
rs1243837718 1333 dbSNP
rs1272482901 1333 dbSNP
rs1283678207 1333 dbSNP
rs1301688687 1333 dbSNP
rs1312965979 1333 dbSNP
rs1323841607 1333 dbSNP
rs1350343854 1333 dbSNP
rs1363235721 1333 dbSNP
rs1392961308 1333 dbSNP
rs1429272829 1333 dbSNP
rs1455333198 1333 dbSNP
rs1475691177 1333 dbSNP
rs71402776 1333 dbSNP
rs926636931 1333 dbSNP
rs138266537 1334 dbSNP
rs1348799004 1335 dbSNP
rs547668302 1336 dbSNP
rs1048893161 1339 dbSNP
rs1284973873 1343 dbSNP
rs930476784 1344 dbSNP
rs1212950200 1350 dbSNP
rs1250935897 1350 dbSNP
rs1476026871 1351 dbSNP
rs1415411946 1362 dbSNP
rs1199272081 1364 dbSNP
rs1232020170 1365 dbSNP
rs1007554966 1371 dbSNP
rs1483360699 1372 dbSNP
rs1461396817 1373 dbSNP
rs1163462867 1374 dbSNP
rs1251294974 1383 dbSNP
rs1197678325 1384 dbSNP
rs1264951203 1391 dbSNP
rs551204633 1396 dbSNP
rs1397286015 1400 dbSNP
rs1251034163 1403 dbSNP
rs528607346 1405 dbSNP
rs889158946 1413 dbSNP
rs1049431454 1414 dbSNP
rs1280239566 1423 dbSNP
rs980765102 1424 dbSNP
rs968091387 1425 dbSNP
rs1271244035 1428 dbSNP
rs1336850124 1430 dbSNP
rs1210274699 1432 dbSNP
rs532715211 1438 dbSNP
rs1233165732 1439 dbSNP
rs915361271 1452 dbSNP
rs994796306 1453 dbSNP
rs1435724435 1455 dbSNP
rs1183472093 1456 dbSNP
rs1252056723 1458 dbSNP
rs34621267 1472 dbSNP
rs1474615884 1474 dbSNP
rs1185147862 1488 dbSNP
rs1420728142 1493 dbSNP
rs988266337 1496 dbSNP
rs1308504416 1501 dbSNP
rs1389246915 1503 dbSNP
rs1411890138 1508 dbSNP
rs1329852726 1517 dbSNP
rs564590942 1523 dbSNP
rs956872853 1524 dbSNP
rs897625939 1528 dbSNP
rs998861256 1531 dbSNP
rs545945595 1532 dbSNP
rs1245342006 1535 dbSNP
rs1250583114 1539 dbSNP
rs1337257950 1542 dbSNP
rs1197297917 1549 dbSNP
rs1462715604 1550 dbSNP
rs964349380 1558 dbSNP
rs1208118129 1559 dbSNP
rs1391968628 1560 dbSNP
rs1424932400 1562 dbSNP
rs530960015 1563 dbSNP
rs1036218825 1564 dbSNP
rs1472863351 1566 dbSNP
rs761652101 1571 dbSNP
rs1169619017 1574 dbSNP
rs1375131055 1580 dbSNP
rs1433035484 1583 dbSNP
rs949768256 1584 dbSNP
rs1376106805 1587 dbSNP
rs1365519762 1591 dbSNP
rs1184070279 1592 dbSNP
rs1324609891 1596 dbSNP
rs1229407771 1598 dbSNP
rs751418240 1603 dbSNP
rs1346708690 1604 dbSNP
rs1208228217 1606 dbSNP
rs1281869976 1609 dbSNP
rs1249926223 1611 dbSNP
rs563629958 1621 dbSNP
rs542152380 1629 dbSNP
rs937006457 1630 dbSNP
rs773434724 1635 dbSNP
rs925649931 1639 dbSNP
rs1394791943 1643 dbSNP
rs1271638358 1649 dbSNP
rs1175710847 1656 dbSNP
rs993966476 1662 dbSNP
rs1453228670 1673 dbSNP
rs895653950 1674 dbSNP
rs763822043 1675 dbSNP
rs191938602 1676 dbSNP
rs1262944975 1691 dbSNP
rs1321012759 1695 dbSNP
rs1369908484 1699 dbSNP
rs763170230 1699 dbSNP
rs1237547058 1714 dbSNP
rs1045036481 1715 dbSNP
rs7563135 1730 dbSNP
rs1258373901 1737 dbSNP
rs966232291 1741 dbSNP
rs1019035410 1742 dbSNP
rs1368392030 1757 dbSNP
rs1007669480 1760 dbSNP
rs988194621 1764 dbSNP
rs1195887477 1767 dbSNP
rs1268386697 1773 dbSNP
rs956870309 1773 dbSNP
rs1324953691 1790 dbSNP
rs953346938 1793 dbSNP
rs922743154 1795 dbSNP
rs1365568484 1804 dbSNP
rs976975152 1808 dbSNP
rs1159878799 1819 dbSNP
rs1027670244 1824 dbSNP
rs995141524 1826 dbSNP
rs541196929 1832 dbSNP
rs1018575492 1835 dbSNP
rs1367884347 1852 dbSNP
rs1390396634 1853 dbSNP
rs1304277377 1860 dbSNP
rs1318151429 1864 dbSNP
rs1228451194 1870 dbSNP
rs897746578 1872 dbSNP
rs1273181277 1878 dbSNP
rs376315786 1881 dbSNP
rs1215953613 1883 dbSNP
rs1266332915 1887 dbSNP
rs765419990 1888 dbSNP
rs1175651643 1889 dbSNP
rs1252900095 1897 dbSNP
rs1363258299 1905 dbSNP
rs1187306542 1908 dbSNP
rs770068730 1909 dbSNP
rs1417153878 1911 dbSNP
rs1174380067 1913 dbSNP
rs1166657286 1915 dbSNP
rs1350215422 1916 dbSNP
rs1461196045 1920 dbSNP
rs1014035356 1925 dbSNP
rs1455737028 1925 dbSNP
rs762240006 1928 dbSNP
rs1251444001 1931 dbSNP
rs114881551 1936 dbSNP
rs558633580 1939 dbSNP
rs1230487671 1943 dbSNP
rs895591566 1951 dbSNP
rs1307332430 1962 dbSNP
rs563734979 1964 dbSNP
rs1055452915 1965 dbSNP
rs1202827962 1968 dbSNP
rs536719423 1970 dbSNP
rs1001412645 1973 dbSNP
rs867146324 1981 dbSNP
rs879025867 1983 dbSNP
rs1042732029 1993 dbSNP
rs186278761 1994 dbSNP
rs1203864288 1995 dbSNP
rs1350642153 1996 dbSNP
rs905773702 2000 dbSNP
rs1427749816 2001 dbSNP
rs1042958444 2003 dbSNP
rs946686572 2004 dbSNP
rs1235928680 2009 dbSNP
rs1345284557 2015 dbSNP
rs1302148645 2019 dbSNP
rs1373045267 2026 dbSNP
rs1449553901 2039 dbSNP
rs759698174 2041 dbSNP
rs554134930 2042 dbSNP
rs1052408704 2044 dbSNP
rs935400224 2046 dbSNP
rs1343146443 2049 dbSNP
rs1381545728 2050 dbSNP
rs1233793261 2053 dbSNP
rs1376059085 2062 dbSNP
rs1278317289 2064 dbSNP
rs1486725313 2069 dbSNP
rs1210871060 2070 dbSNP
rs988835836 2074 dbSNP
rs977320193 2080 dbSNP
rs1436587711 2083 dbSNP
rs942883566 2085 dbSNP
rs1393364650 2088 dbSNP
rs535793239 2089 dbSNP
rs1449721539 2090 dbSNP
rs1172680503 2091 dbSNP
rs541996384 2094 dbSNP
rs1172168427 2097 dbSNP
rs944836349 2098 dbSNP
rs1475884629 2100 dbSNP
rs142769788 2112 dbSNP
rs1191551374 2120 dbSNP
rs1334233739 2121 dbSNP
rs1345133332 2124 dbSNP
rs139566648 2125 dbSNP
rs952334655 2126 dbSNP
rs953462549 2127 dbSNP
rs1028031496 2128 dbSNP
rs972456501 2134 dbSNP
rs528701636 2138 dbSNP
rs1484369090 2139 dbSNP
rs570931405 2140 dbSNP
rs575111836 2141 dbSNP
rs146300001 2145 dbSNP
rs80261926 2146 dbSNP
rs565075240 2154 dbSNP
rs1226512100 2155 dbSNP
rs1206684759 2167 dbSNP
rs1249792177 2191 dbSNP
rs1021469426 2197 dbSNP
rs1192767522 2199 dbSNP
rs895622284 2201 dbSNP
rs1478774617 2208 dbSNP
rs1172663228 2210 dbSNP
rs1011429457 2211 dbSNP
rs1399490243 2213 dbSNP
rs1162063929 2214 dbSNP
rs1302874647 2219 dbSNP
rs1461313080 2221 dbSNP
rs891741702 2231 dbSNP
rs1412882542 2236 dbSNP
rs775339832 2239 dbSNP
rs1333643341 2251 dbSNP
rs1410727613 2255 dbSNP
rs745681818 2259 dbSNP
rs1166510646 2267 dbSNP
rs1230267160 2268 dbSNP
rs538260358 2280 dbSNP
rs563710993 2293 dbSNP
rs77799108 2300 dbSNP
rs778580038 2318 dbSNP
rs542238093 2319 dbSNP
rs904279773 2321 dbSNP
rs1190636531 2324 dbSNP
rs1453004229 2325 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions Hela
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1048187. RNA binding protein: AGO2. Condition:Hela_AGO2_CLIP_control ...

- Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al., 2013, Cell.

Article - Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al.
- Cell, 2013
The induction of pluripotency or trans-differentiation of one cell type to another can be accomplished with cell-lineage-specific transcription factors. Here, we report that repression of a single RNA binding polypyrimidine-tract-binding (PTB) protein, which occurs during normal brain development via the action of miR-124, is sufficient to induce trans-differentiation of fibroblasts into functional neurons. Besides its traditional role in regulated splicing, we show that PTB has a previously undocumented function in the regulation of microRNA functions, suppressing or enhancing microRNA targeting by competitive binding on target mRNA or altering local RNA secondary structure. A key event during neuronal induction is the relief of PTB-mediated blockage of microRNA action on multiple components of the REST complex, thereby derepressing a large array of neuronal genes, including miR-124 and multiple neuronal-specific transcription factors, in nonneuronal cells. This converts a negative feedback loop to a positive one to elicit cellular reprogramming to the neuronal lineage.
LinkOut: [PMID: 23313552]
CLIP-seq Support 1 for dataset GSM1048187
Method / RBP HITS-CLIP / AGO2
Cell line / Condition Hela / Hela_AGO2_CLIP_control
Location of target site ENST00000254658.3 | 3UTR | AAGAAGCCUAGUGGUUUGUGUGGCCAACUCCAUC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23313552 / GSE42701
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
29 hsa-miR-4540 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT154897 GNAS GNAS complex locus 2 2
MIRT444915 PSG11 pregnancy specific beta-1-glycoprotein 11 2 2
MIRT446718 PSG3 pregnancy specific beta-1-glycoprotein 3 2 2
MIRT464587 UBN2 ubinuclein 2 2 2
MIRT468816 RSRC2 arginine and serine rich coiled-coil 2 2 6
MIRT469397 REL REL proto-oncogene, NF-kB subunit 2 6
MIRT491901 YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon 2 2
MIRT498959 ORC4 origin recognition complex subunit 4 2 8
MIRT499438 ODF2L outer dense fiber of sperm tails 2 like 2 8
MIRT506234 PEX13 peroxisomal biogenesis factor 13 2 4
MIRT527911 B3GALT5 beta-1,3-galactosyltransferase 5 2 2
MIRT532624 PHF5A PHD finger protein 5A 2 2
MIRT538103 DDX6 DEAD-box helicase 6 2 2
MIRT549032 CASZ1 castor zinc finger 1 2 2
MIRT559870 ATXN3 ataxin 3 2 2
MIRT575888 Ablim1 actin-binding LIM protein 1 2 4
MIRT608663 ABLIM1 actin binding LIM protein 1 2 5
MIRT616515 C9orf170 chromosome 9 open reading frame 170 2 2
MIRT624063 EID1 EP300 interacting inhibitor of differentiation 1 2 2
MIRT625533 RALGAPB Ral GTPase activating protein non-catalytic beta subunit 2 2
MIRT637169 TMEM50A transmembrane protein 50A 2 2
MIRT639274 KLHL23 kelch like family member 23 2 2
MIRT642924 CCDC90B coiled-coil domain containing 90B 2 2
MIRT649085 FBXO25 F-box protein 25 2 2
MIRT655089 PI4K2A phosphatidylinositol 4-kinase type 2 alpha 2 2
MIRT700888 PER2 period circadian clock 2 2 2
MIRT705966 ACBD5 acyl-CoA binding domain containing 5 2 2
MIRT709418 FBXL20 F-box and leucine rich repeat protein 20 2 2
MIRT723921 ADAMTS15 ADAM metallopeptidase with thrombospondin type 1 motif 15 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-4540 Topotecan 60699 NSC609699 approved resistant cell line (W1)
hsa-miR-4540 Tamoxifen 2733525 NSC180973 approved resistant cell line (LCC2)
hsa-miR-4540 Platinum 23939 resistant tissue (non-small cell lung cancer)

Error report submission