pre-miRNA Information
pre-miRNA hsa-mir-4480   
Genomic Coordinates chr10: 12578753 - 12578823
Description Homo sapiens miR-4480 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4480
Sequence 44| AGCCAAGUGGAAGUUACUUUA |64
Evidence Experimental
Experiments Illumina
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 1 10 + 12578796 23291724, 27587585 MiREDiBase
A-to-I 12 10 + 12578807 23291724, 27587585 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs929437808 7 dbSNP
rs1454494557 9 dbSNP
rs1345041659 17 dbSNP
rs561601367 21 dbSNP
Putative Targets

Gene Information
Gene Symbol PDIA6   
Synonyms ERP5, P5, TXNDC7
Description protein disulfide isomerase family A member 6
Transcript NM_005742   
Expression
Putative miRNA Targets on PDIA6
3'UTR of PDIA6
(miRNA target sites are highlighted)
>PDIA6|NM_005742|3'UTR
   1 GAGCCACAACAGAGGCTTCAGACCATTTTCTTTTCTTGGGAGCCAGTGGATTTTTCCAGCAGTGAAGGGACATTCTCTAC
  81 ACTCAGATGACTCTACCAGTGGCCTTTTAACCAAGAAGTAGTACTTGATTGGTCATTTGAAAACACTGCAACAGTGAACT
 161 TTTGCATCTCAAGAAAACATTGAAAAATTCTATGAATTGTTGTAGCCGGTGAATTGAGTCGTATTCTGTCACATAATATT
 241 TTGAAGAAAACTTGGCTGTCGAAACATTTTTCTCTCTGACTGCTGCTTGAATGTTCTTGGAGGCTGTTTCTTATGTATGG
 321 GTTTTTTTTAATGTGATCCCTTCATTTGAATATTAATGGCTTTTTCCATTAAAGAATAAAATATTTTGGACAATGCCGAT
 401 AAATGTATGAAGTTAGTATCCACATCATAAATTCAGAGTGATGTTTAGCAGTAAATCAATATTTTGAAGTGATACACAGA
 481 TGTCTTTCCTCCCCACAAACTTTTTTAAACAAAAAACAAGACCTCTTTTCTTTAGATGGTGCCACCTATGCCCACCACAA
 561 CAGAGATTTTACATGGAAACCGGGCTCAGTGAGAACTGATTTCCTGCCCAATATTTGTCTTTGGGCTGTCTCTAGTGACT
 641 AATTATTAAGGAATCTAGCTGGTTATACAGTTCAAGGCTTTCTATGTTGTTAATGAACCTCAAAATAGCCGTTAAGACAT
 721 GAAATACAGCAGCAGGTTACCAATGCGAACAGGTAGTTCGCATTTATGTAAAACATTCAGAAAATGAAGTTTTGAATTTG
 801 TTGGAACATTCAAAGGACTTGAGAGCATTTTATTGTAACTTAAAAAAATAAATACAACTGTCACTAAAAAAAAAAAAAAA
 881 AAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' auUUCAUUGAAGGUGAACCGa 5'
            ||| ||     ||||||| 
Target 5' tgAAGAAA-----ACTTGGCt 3'
242 - 257 146.00 -10.80
2
miRNA  3' auUUCAUUGAAGGUGAACcga 5'
            ||| || |  :|||||   
Target 5' ccAAG-AAGTAGTACTTGatt 3'
111 - 130 114.00 -8.60
3
miRNA  3' auuuCAUUGAAGG-----UGAACcga 5'
              | ||| |:|     |||||   
Target 5' tgttGGAACATTCAAAGGACTTGaga 3'
799 - 824 109.00 -5.80
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30490989 24 COSMIC
COSN31554237 28 COSMIC
COSN30525354 38 COSMIC
COSN30150852 64 COSMIC
COSN25778987 93 COSMIC
COSN30612677 105 COSMIC
COSN31537417 120 COSMIC
COSN8606955 139 COSMIC
COSN26553286 165 COSMIC
COSN31605127 190 COSMIC
COSN8606954 344 COSMIC
COSN28201689 360 COSMIC
COSN26481476 397 COSMIC
COSN31550165 492 COSMIC
COSN30162470 821 COSMIC
COSN6201298 850 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1206695821 4 dbSNP
rs754632785 8 dbSNP
rs1459011709 10 dbSNP
rs1246161953 25 dbSNP
rs751303813 27 dbSNP
rs544797096 34 dbSNP
rs14337 35 dbSNP
rs899845616 36 dbSNP
rs1214435021 38 dbSNP
rs1448476471 38 dbSNP
rs565556427 40 dbSNP
rs550184829 41 dbSNP
rs1270344905 45 dbSNP
rs200948949 49 dbSNP
rs887430557 50 dbSNP
rs1198194439 52 dbSNP
rs1039753738 56 dbSNP
rs943260589 58 dbSNP
rs1159474648 62 dbSNP
rs1384776717 68 dbSNP
rs202243910 72 dbSNP
rs1305499797 75 dbSNP
rs1225590863 79 dbSNP
rs111359980 81 dbSNP
rs11545886 82 dbSNP
rs764717987 87 dbSNP
rs1324853374 92 dbSNP
rs1182933978 93 dbSNP
rs1299404110 96 dbSNP
rs554444008 99 dbSNP
rs750051227 99 dbSNP
rs1293213107 102 dbSNP
rs1240112556 114 dbSNP
rs1279910041 124 dbSNP
rs781657625 124 dbSNP
rs929035806 129 dbSNP
rs919032646 131 dbSNP
rs776004654 134 dbSNP
rs1293904064 143 dbSNP
rs1490357585 148 dbSNP
rs1208708529 162 dbSNP
rs972889889 163 dbSNP
rs1362366896 168 dbSNP
rs929164594 180 dbSNP
rs1439186626 187 dbSNP
rs867675005 188 dbSNP
rs1182148132 201 dbSNP
rs944206748 202 dbSNP
rs1438226611 206 dbSNP
rs545130737 207 dbSNP
rs574650183 208 dbSNP
rs1045476595 209 dbSNP
rs1176444991 211 dbSNP
rs1804107 219 dbSNP
rs1398802714 220 dbSNP
rs985687783 221 dbSNP
rs1370946571 223 dbSNP
rs1328444016 231 dbSNP
rs954319651 236 dbSNP
rs1237722859 239 dbSNP
rs1316963704 240 dbSNP
rs763566779 243 dbSNP
rs556342717 251 dbSNP
rs537921891 252 dbSNP
rs1429533013 254 dbSNP
rs1264283945 258 dbSNP
rs1182365102 260 dbSNP
rs1237220334 262 dbSNP
rs926232609 267 dbSNP
rs1158293897 274 dbSNP
rs1244205045 278 dbSNP
rs977952852 283 dbSNP
rs979437075 284 dbSNP
rs1461209371 289 dbSNP
rs558700720 299 dbSNP
rs1263851583 302 dbSNP
rs967557022 303 dbSNP
rs1021463049 304 dbSNP
rs1804105 307 dbSNP
rs1454821626 309 dbSNP
rs1338445730 310 dbSNP
rs3208276 310 dbSNP
rs1013398965 314 dbSNP
rs896325028 317 dbSNP
rs998255403 322 dbSNP
rs1327633650 326 dbSNP
rs1227548154 329 dbSNP
rs201184814 330 dbSNP
rs964145805 330 dbSNP
rs1205242239 336 dbSNP
rs1264081943 337 dbSNP
rs1033542840 355 dbSNP
rs1180583860 356 dbSNP
rs1264511428 358 dbSNP
rs1299462878 360 dbSNP
rs1002101456 362 dbSNP
rs1429682558 366 dbSNP
rs568869179 374 dbSNP
rs190113887 381 dbSNP
rs1381884629 384 dbSNP
rs771153946 389 dbSNP
rs16856645 393 dbSNP
rs897533824 398 dbSNP
rs764474348 405 dbSNP
rs1177433098 407 dbSNP
rs1393665407 414 dbSNP
rs75496500 415 dbSNP
rs1462179090 433 dbSNP
rs1048976610 435 dbSNP
rs993715964 436 dbSNP
rs1382749847 438 dbSNP
rs1277003935 449 dbSNP
rs1337791975 452 dbSNP
rs1224897136 459 dbSNP
rs540403004 460 dbSNP
rs1283559712 469 dbSNP
rs1161999495 470 dbSNP
rs897678579 473 dbSNP
rs768843380 475 dbSNP
rs1244335466 479 dbSNP
rs1216599597 482 dbSNP
rs949786036 488 dbSNP
rs915701646 492 dbSNP
rs912708762 499 dbSNP
rs1436206948 500 dbSNP
rs985633554 509 dbSNP
rs932897710 515 dbSNP
rs1249900009 517 dbSNP
rs1055861982 522 dbSNP
rs1420168616 527 dbSNP
rs1297511047 530 dbSNP
rs1358025549 537 dbSNP
rs1406265776 545 dbSNP
rs1303281631 547 dbSNP
rs1366426475 552 dbSNP
rs935682422 561 dbSNP
rs6748808 563 dbSNP
rs1239979727 569 dbSNP
rs977715188 570 dbSNP
rs1243445262 571 dbSNP
rs1223293796 573 dbSNP
rs536167576 581 dbSNP
rs569043087 582 dbSNP
rs1315706296 589 dbSNP
rs1409803688 597 dbSNP
rs550809230 605 dbSNP
rs1440112037 609 dbSNP
rs979362193 611 dbSNP
rs1246884080 623 dbSNP
rs769738262 639 dbSNP
rs149491730 644 dbSNP
rs753510066 645 dbSNP
rs1426513132 652 dbSNP
rs185405157 656 dbSNP
rs1348848519 662 dbSNP
rs1301717828 663 dbSNP
rs964115413 665 dbSNP
rs1018369848 669 dbSNP
rs1060002 682 dbSNP
rs1060005 684 dbSNP
rs1386233609 686 dbSNP
rs9314 688 dbSNP
rs754777878 689 dbSNP
rs1033508251 692 dbSNP
rs1289224660 692 dbSNP
rs182197560 693 dbSNP
rs951906281 697 dbSNP
rs1027573378 700 dbSNP
rs565321075 700 dbSNP
rs200126259 701 dbSNP
rs1484176515 703 dbSNP
rs192453762 710 dbSNP
rs868846415 711 dbSNP
rs1060011 718 dbSNP
rs1040067583 728 dbSNP
rs1172026596 739 dbSNP
rs767492833 741 dbSNP
rs562708971 744 dbSNP
rs544385606 746 dbSNP
rs749964258 747 dbSNP
rs1211574924 752 dbSNP
rs1348387684 753 dbSNP
rs1278471108 760 dbSNP
rs1216379685 768 dbSNP
rs1239092485 779 dbSNP
rs1317513483 797 dbSNP
rs11489 803 dbSNP
rs1255849980 807 dbSNP
rs756826731 808 dbSNP
rs773463524 809 dbSNP
rs1236861211 811 dbSNP
rs1366583072 813 dbSNP
rs559009388 821 dbSNP
rs1055566679 823 dbSNP
rs932825437 833 dbSNP
rs753318318 835 dbSNP
rs1415424877 841 dbSNP
rs904175287 849 dbSNP
rs1357896631 855 dbSNP
rs1433579708 858 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions Hela
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1048187. RNA binding protein: AGO2. Condition:Hela_AGO2_CLIP_control ...

- Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al., 2013, Cell.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' auuucauugaaggUGAACCGa 5'
                       ||||||| 
Target 5' -------------ACUUGGCu 3'
1 - 8
2
miRNA  3' auuucAUUGAAGGUGAACcga 5'
               |:||| |::||||   
Target 5' cucucUGACUGCUGCUUGaau 3'
23 - 43
Article - Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al.
- Cell, 2013
The induction of pluripotency or trans-differentiation of one cell type to another can be accomplished with cell-lineage-specific transcription factors. Here, we report that repression of a single RNA binding polypyrimidine-tract-binding (PTB) protein, which occurs during normal brain development via the action of miR-124, is sufficient to induce trans-differentiation of fibroblasts into functional neurons. Besides its traditional role in regulated splicing, we show that PTB has a previously undocumented function in the regulation of microRNA functions, suppressing or enhancing microRNA targeting by competitive binding on target mRNA or altering local RNA secondary structure. A key event during neuronal induction is the relief of PTB-mediated blockage of microRNA action on multiple components of the REST complex, thereby derepressing a large array of neuronal genes, including miR-124 and multiple neuronal-specific transcription factors, in nonneuronal cells. This converts a negative feedback loop to a positive one to elicit cellular reprogramming to the neuronal lineage.
LinkOut: [PMID: 23313552]
CLIP-seq Support 1 for dataset GSM4903833
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_a
Location of target site NM_005742 | 3UTR | GUGGCCUUUUAACCAAGAAGUAGUACUUGAUUGGUCAUUUGAAAACACUGCAACAGUGAACUUUUGCAUCUCAAGAAAACAUUGAAAAAUUCUAUGAAUUGUUGUAGCCGGUGAAUUGAGUCGUAUUCUGUCACAUAAUAUUUUGAAGAAAACUUGGCUGUCGAAACAU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1048187
Method / RBP HITS-CLIP / AGO2
Cell line / Condition Hela / Hela_AGO2_CLIP_control
Location of target site ENST00000272227.3 | 3UTR | ACUUGGCUGUCGAAACAUUUUUCUCUCUGACUGCUGCUUGAAUGUUCUUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23313552 / GSE42701
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
117 hsa-miR-4480 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT056040 MLLT10 MLLT10, histone lysine methyltransferase DOT1L cofactor 2 2
MIRT091259 FXR1 FMR1 autosomal homolog 1 2 4
MIRT117347 MAPRE2 microtubule associated protein RP/EB family member 2 2 2
MIRT234960 ZNF439 zinc finger protein 439 2 4
MIRT441356 ZNF75A zinc finger protein 75a 2 2
MIRT441426 STXBP2 syntaxin binding protein 2 2 2
MIRT441455 ZNF488 zinc finger protein 488 2 4
MIRT441524 ZBTB10 zinc finger and BTB domain containing 10 2 2
MIRT441576 EXOC5 exocyst complex component 5 2 2
MIRT441597 ABCB5 ATP binding cassette subfamily B member 5 2 6
MIRT441610 ATP13A4 ATPase 13A4 2 2
MIRT441698 CIT citron rho-interacting serine/threonine kinase 2 2
MIRT441714 FGF9 fibroblast growth factor 9 2 2
MIRT441784 MAPK8 mitogen-activated protein kinase 8 2 4
MIRT441795 EXOSC2 exosome component 2 2 2
MIRT441868 RNASEL ribonuclease L 2 2
MIRT441900 SLC9A8 solute carrier family 9 member A8 2 6
MIRT441919 FAM217B family with sequence similarity 217 member B 2 2
MIRT441928 C1orf109 chromosome 1 open reading frame 109 2 2
MIRT441938 RIMKLB ribosomal modification protein rimK like family member B 2 2
MIRT442157 DPY19L1 dpy-19 like C-mannosyltransferase 1 2 2
MIRT442172 AZF1 azoospermia factor 1 2 2
MIRT442208 IRS1 insulin receptor substrate 1 2 2
MIRT442237 DDX19A DEAD-box helicase 19A 2 2
MIRT442366 ZC3HAV1L zinc finger CCCH-type containing, antiviral 1 like 2 2
MIRT442572 SDC1 syndecan 1 2 2
MIRT442604 ZNF391 zinc finger protein 391 2 2
MIRT442609 MRC1 mannose receptor C-type 1 2 2
MIRT442647 POP4 POP4 homolog, ribonuclease P/MRP subunit 2 2
MIRT442658 OIP5 Opa interacting protein 5 2 6
MIRT442686 COX15 COX15, cytochrome c oxidase assembly homolog 2 2
MIRT442773 JAG1 jagged 1 2 2
MIRT442785 CHD8 chromodomain helicase DNA binding protein 8 2 2
MIRT442895 PLCB3 phospholipase C beta 3 2 2
MIRT442941 C17orf105 chromosome 17 open reading frame 105 2 2
MIRT442959 SGCD sarcoglycan delta 2 2
MIRT442998 EDAR ectodysplasin A receptor 2 2
MIRT443017 C21orf91 chromosome 21 open reading frame 91 2 2
MIRT443064 CASP5 caspase 5 2 2
MIRT443069 ABLIM1 actin binding LIM protein 1 2 2
MIRT443208 VPS36 vacuolar protein sorting 36 homolog 2 2
MIRT443237 ANKRD26 ankyrin repeat domain 26 2 2
MIRT443253 A1CF APOBEC1 complementation factor 2 2
MIRT443329 JUN Jun proto-oncogene, AP-1 transcription factor subunit 2 2
MIRT443333 NRAS NRAS proto-oncogene, GTPase 2 2
MIRT443349 STX7 syntaxin 7 2 2
MIRT443452 CLIC5 chloride intracellular channel 5 2 2
MIRT443547 GPR35 G protein-coupled receptor 35 2 2
MIRT443616 AVPR1A arginine vasopressin receptor 1A 2 2
MIRT443626 CPSF2 cleavage and polyadenylation specific factor 2 2 2
MIRT443730 ALPK3 alpha kinase 3 2 2
MIRT443786 ST13 ST13, Hsp70 interacting protein 2 2
MIRT443852 RGS6 regulator of G protein signaling 6 2 2
MIRT445483 KLF5 Kruppel like factor 5 2 2
MIRT471105 PHLDA2 pleckstrin homology like domain family A member 2 2 2
MIRT472329 NETO2 neuropilin and tolloid like 2 2 4
MIRT472391 NDRG3 NDRG family member 3 2 2
MIRT473522 MAX MYC associated factor X 2 2
MIRT473874 MAFK MAF bZIP transcription factor K 2 6
MIRT476021 GTF2A1 general transcription factor IIA subunit 1 2 2
MIRT478320 DDN dendrin 2 2
MIRT492049 TNFSF9 TNF superfamily member 9 2 2
MIRT494851 ANKRD24 ankyrin repeat domain 24 2 2
MIRT494991 TSSC1 EARP complex and GARP complex interacting protein 1 2 2
MIRT495034 RASSF2 Ras association domain family member 2 2 2
MIRT495111 NOL10 nucleolar protein 10 2 2
MIRT495113 TRADD TNFRSF1A associated via death domain 2 2
MIRT495131 METTL24 methyltransferase like 24 2 2
MIRT495147 STAC2 SH3 and cysteine rich domain 2 2 2
MIRT495297 NUP54 nucleoporin 54 2 2
MIRT495341 RTN2 reticulon 2 2 2
MIRT495347 ATP5S ATP synthase, H+ transporting, mitochondrial Fo complex subunit s (factor B) 2 2
MIRT496682 DUSP18 dual specificity phosphatase 18 2 2
MIRT496743 TGFBR1 transforming growth factor beta receptor 1 2 2
MIRT496841 KCNIP2 potassium voltage-gated channel interacting protein 2 2 2
MIRT496852 GPAM glycerol-3-phosphate acyltransferase, mitochondrial 2 2
MIRT496889 FOXP1 forkhead box P1 2 2
MIRT496922 CLMN calmin 2 2
MIRT496990 TMEM231 transmembrane protein 231 2 2
MIRT497002 SNAP25 synaptosome associated protein 25 2 2
MIRT497058 C6orf223 chromosome 6 open reading frame 223 2 2
MIRT500529 YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta 2 6
MIRT506048 PPP6C protein phosphatase 6 catalytic subunit 2 4
MIRT512163 CD164 CD164 molecule 2 6
MIRT527051 RDH13 retinol dehydrogenase 13 2 2
MIRT532282 TNFSF14 TNF superfamily member 14 2 2
MIRT534083 SPRY4 sprouty RTK signaling antagonist 4 2 2
MIRT534605 RNASEH1 ribonuclease H1 2 4
MIRT539509 ACSS3 acyl-CoA synthetase short chain family member 3 2 2
MIRT543069 ARID4B AT-rich interaction domain 4B 2 2
MIRT544233 CCBL2 kynurenine aminotransferase 3 2 2
MIRT544686 ZNF224 zinc finger protein 224 2 4
MIRT546269 TMEM30A transmembrane protein 30A 2 4
MIRT559069 C19orf47 chromosome 19 open reading frame 47 2 2
MIRT562768 RMI2 RecQ mediated genome instability 2 2 2
MIRT563974 HCFC1 host cell factor C1 2 2
MIRT564086 NSA2 NSA2, ribosome biogenesis homolog 2 2
MIRT564525 PDXP pyridoxal phosphatase 2 2
MIRT564613 ZNF703 zinc finger protein 703 2 2
MIRT566252 PTBP1 polypyrimidine tract binding protein 1 2 2
MIRT614420 ZNF440 zinc finger protein 440 2 2
MIRT618789 MTHFR methylenetetrahydrofolate reductase 2 2
MIRT619160 PPDPF pancreatic progenitor cell differentiation and proliferation factor 2 2
MIRT641778 ZDHHC7 zinc finger DHHC-type containing 7 2 4
MIRT653680 SLC25A36 solute carrier family 25 member 36 2 2
MIRT657861 GJD2 gap junction protein delta 2 2 2
MIRT660879 ADCYAP1R1 ADCYAP receptor type I 2 2
MIRT668781 DAAM1 dishevelled associated activator of morphogenesis 1 2 4
MIRT688559 DCAF16 DDB1 and CUL4 associated factor 16 2 2
MIRT695393 WDR41 WD repeat domain 41 2 2
MIRT698680 TCEA1 transcription elongation factor A1 2 2
MIRT700974 PDIA6 protein disulfide isomerase family A member 6 2 2
MIRT705055 C5orf15 chromosome 5 open reading frame 15 2 2
MIRT705864 AFF1 AF4/FMR2 family member 1 2 2
MIRT710586 CDCA4 cell division cycle associated 4 2 2
MIRT713904 IGF2R insulin like growth factor 2 receptor 2 2
MIRT717133 SKI SKI proto-oncogene 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4480 Cisplatin 5460033 NSC119875 approved sensitive cell line (CIS)
hsa-miR-4480 Cisplatin 5460033 NSC119875 approved resistant cell line (A549)

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