pre-miRNA Information | |
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pre-miRNA | hsa-mir-103b-1 |
Genomic Coordinates | chr5: 168560904 - 168560965 |
Description | Homo sapiens miR-103b-1 stem-loop |
Comment | None |
RNA Secondary Structure | ![]() |
Associated Diseases | ![]() |
pre-miRNA | hsa-mir-103b-2 |
Genomic Coordinates | chr20: 3917502 - 3917563 |
Description | Homo sapiens miR-103b-2 stem-loop |
Comment | None |
RNA Secondary Structure | ![]() |
Associated Diseases | ![]() |
Mature miRNA Information | ||||||||||||||||||||||
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Mature miRNA | hsa-miR-103b | |||||||||||||||||||||
Sequence | 1| UCAUAGCCCUGUACAAUGCUGCU |23 | |||||||||||||||||||||
Evidence | Experimental | |||||||||||||||||||||
Experiments | ChIP-seq | DRVs in miRNA |
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SNPs in miRNA |
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Putative Targets |
Gene Information | |||||||||||||||||||||
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Gene Symbol | MSL1 | ||||||||||||||||||||
Synonyms | MSL-1, hMSL1 | ||||||||||||||||||||
Description | male specific lethal 1 homolog | ||||||||||||||||||||
Transcript | NM_001012241 | ||||||||||||||||||||
Expression | |||||||||||||||||||||
Putative miRNA Targets on MSL1 | |||||||||||||||||||||
3'UTR of MSL1 (miRNA target sites are highlighted) |
>MSL1|NM_001012241|3'UTR 1 CTGTGCTGGCAAGAACCCTGTCTTCAGATAGTTGTAGCATGCCATTCCCGAGAGTGGCAGAGACCTGTATATGTGACCTT 81 TGTCCTCACATATGTTATCACTCGCTGATAATACCCTTTCATACTTCCTTGACTTTGTTTTCATTACTCTGATTTCACAA 161 AAACTCTTTCATTCGGCTAATTGTGAGTTATGGAGGGTGATTGGGATTTCTTTTCCCTTTTTTGGGAAATGGGCTCTCAA 241 GCTAAAGCTATAGGATGGCAGATTCAGAAGTTTCAGGGGTCTGTTTCTATACATTTGCCTATGTTAAAGGGGTAAAAGGG 321 CTCTCTTCATTAGACATGTGGAAGATGAAGCAGCCCCTTCCTTTAGAGCTGTGCCTGCATGGCACTCTTCTCACCCTGGT 401 ACACCCTCCTTATAGTGGGTATAGTGATTTTTAACCCTAAAATAAAACAAACAACCTCACCATGAGCTTTAGGACCAGAA 481 GAGGAATGACAAGTGAAGCGATGAAGCAAGCCATCTTCACAGAGTAGAAAAGACATCGGAGAGTTGGTAGATAACTGTCT 561 GAAAAGATAGTTGTTCATTTGAAACTATTCTGTGATACAGTCATGTGGGAAGGGATGTTTGGCTGTGATTATTTTTTCAG 641 TTAATGGATAACAATTTCTTTACTGCTCAAAAACCAAAATCTTTGGAAAAGAAAGTGGGGATGGTTAGTTTCAGAACAAG 721 TTACAGCTGTAAACAAAAGCACTTAGTATTTGGGATGGCATGCCAAAACCTGTATAAATGTCCTTGTATCACATCACTTC 801 TCAAGTATTCCTTCATTGGGCTTCATCCTTTTAGCAGAACTCTTGGTGGTGGGATAGAGACTTAGGGAGGGTAGGGGGAG 881 AGTGTGGAAATAGGTGCTTCCTTTGGCTGGCAAATGTCTACATCTTGAAACAAACAGATGTACCTAATGAGCTTCTCCAT 961 TCACTTTGTAAAAATAATTTGTATGTGTACCATCTTGGTCCTCTCCCCTCCCGTTTTGTTAAAATATCAGGATAGCACTC 1041 CCAGGCCACTTTGGTCTCAGTGTAAGATCCCTATTAACTATCTGAAAGGAAAATAGAGCCAAGACCTCTGGTCTCAAATA 1121 TATAGGAATTGCCTTTCTTTAGTCTTCAGGACTATTGTGTGAAAACAAGTAGGGGTCTAATCTCCTAGAAGGTAGGGGCT 1201 TTTATCCTTAAAGAGAATATGTCCCCAGATTATTAGCACTTTTAGAGGAGAAGCCAAGGTATGTAGGGTGTGTGGCTGGC 1281 CCATCAGTGGAGCACGAAGAGAGAATGGGATACCATTGTGGGAAGAGAAGAAAAGTTCCTCAGGGGCCTCCCACTGCTAA 1361 AGTTTTTTGTGAGATGTTGATCTGTGCTTCCTGGATTTGACTTTTAAAGGAATTATTCTGGCAGCACATGTAGTATTCTT 1441 GGATGATCTTGCTGCTCTTATTTCTCCTTTTGTGTGTGTGTGTGTGTGTGTGTGGCTATGGGTTTTCATTTGTAACTCCA 1521 TCTGCTTAGGAGAGTGGGCTCTCTATAAGGGAACCTGCTGTAAACTTCATTGCAGCAAGGATGTAGAGAGAAATAGGACT 1601 TAATTCCACTAGGGGCTCTCATCTCACACCTTAAGGAGGAGATTTCTAGAAAAACTGGGCCAGATTTTCTTTGTTCTCCA 1681 TCATTTTAATGTGGCAGGCTGTTCAGTTTTCTTACTCTTACCTATGTGATATTTCTTCGTAACGTGTCCAAAAAGAAAAA 1761 AGACCCAATCAGTGTCTCTTGACTTTGTTCTTTGATCCCTCAGTTTCTTCTTGATTTCAGCATGTGTCGGGTTCCTAATT 1841 TTGGGTATGAGTTAGCAAATTTAACCATTGTGTTTGTGCCCTACCCAGGGGACTCCCCAGTTTCTGACTTGAAGTAGACT 1921 GAGAAGAATCCACGAGGTGCTATCTGGCCAGATTTAAGTAGATTCTATTTCCTTGGTTCTCCCTCTCCCTGAGGACCTCT 2001 TATTTTATTGTCCCCTCTTCTAGGTTAATTCTCCTTTGATTTGACTTTGTTGAGAAGGAGGTTGGACAGTAGATTAGCAA 2081 AGTTCCAAGTGCAAAATTACAGTGTGTTAGAGTGTGGGGGGAAAATTAGTCTTATTTTTCCCTACATGGGATACAACACT 2161 GTGAATTCAATCTTCAACTGAAGGCCCTGCAGTTCTCCTAAAACATAGTTGTTTGTTTTTCTTTAACAAAGTTTAAGCTA 2241 GTGTTAATAAATTAAAAAAAATTGCTTGTCTGTCTACTTCAGCTTTGTTTTATGCCCATTTCATATTGTTGTCTGTGTTG 2321 TAATTCATAACTTTTGATACCATTTCTGATGTGTAAAATTGGTTGTCTTGTAAATATCTTATAAAGAGTTCAATTGTAAA 2401 TAAACTATTGTGGCTGTTAAAAAAAAAAAAAAAAAAA Target sites
Provided by authors
Predicted by miRanda
DRVs
SNPs
DRVs & SNPs
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miRNA-target interactions (Predicted by miRanda) |
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DRVs in gene 3'UTRs | |||||||||||||||||||||
SNPs in gene 3'UTRs |
Experimental Support 1 for Functional miRNA-Target Interaction | |
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miRNA:Target | ---- |
Validation Method |
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Conditions | Hela |
Location of target site | 3'UTR |
Tools used in this research | TargetScan , miRTarCLIP , Piranha |
Original Description (Extracted from the article) |
...
HITS-CLIP data was present in GSM1048187. RNA binding protein: AGO2. Condition:Hela_AGO2_CLIP_control
... - Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al., 2013, Cell. |
Article |
- Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al. - Cell, 2013
The induction of pluripotency or trans-differentiation of one cell type to another can be accomplished with cell-lineage-specific transcription factors. Here, we report that repression of a single RNA binding polypyrimidine-tract-binding (PTB) protein, which occurs during normal brain development via the action of miR-124, is sufficient to induce trans-differentiation of fibroblasts into functional neurons. Besides its traditional role in regulated splicing, we show that PTB has a previously undocumented function in the regulation of microRNA functions, suppressing or enhancing microRNA targeting by competitive binding on target mRNA or altering local RNA secondary structure. A key event during neuronal induction is the relief of PTB-mediated blockage of microRNA action on multiple components of the REST complex, thereby derepressing a large array of neuronal genes, including miR-124 and multiple neuronal-specific transcription factors, in nonneuronal cells. This converts a negative feedback loop to a positive one to elicit cellular reprogramming to the neuronal lineage.
LinkOut: [PMID: 23313552]
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CLIP-seq Support 1 for dataset GSM1048187 | |
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Method / RBP | HITS-CLIP / AGO2 |
Cell line / Condition | Hela / Hela_AGO2_CLIP_control |
Location of target site | ENST00000398532.4 | 3UTR | AUUUCUCCUUUUGUGUGUGUGUGUGUGUGUGUGUGG |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 23313552 / GSE42701 |
CLIP-seq Viewer | Link |
MiRNA-Target Expression Profile | |||||||||||||||||||||
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MiRNA-Target Expression Profile (TCGA) | |||||||
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53 hsa-miR-103b Target Genes:
Functional analysis:
ID![]() |
Target | Description | Validation methods |
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Strong evidence | Less strong evidence | |||||||||||
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MIRT218386 | E2F3 | E2F transcription factor 3 | ![]() |
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2 | 2 | ||||||
MIRT404221 | RPL7L1 | ribosomal protein L7 like 1 | ![]() |
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2 | 2 | ||||||
MIRT441502 | SPG20 | spartin | ![]() |
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2 | 6 | ||||||
MIRT444124 | ZNRF3 | zinc and ring finger 3 | ![]() |
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2 | 2 | ||||||
MIRT454236 | OSBPL10 | oxysterol binding protein like 10 | ![]() |
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2 | 4 | ||||||
MIRT457919 | ZNF212 | zinc finger protein 212 | ![]() |
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2 | 2 | ||||||
MIRT462254 | LAMA4 | laminin subunit alpha 4 | ![]() |
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2 | 2 | ||||||
MIRT463176 | ZNF281 | zinc finger protein 281 | ![]() |
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2 | 2 | ||||||
MIRT472355 | TSPAN1 | tetraspanin 1 | ![]() |
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2 | 2 | ||||||
MIRT474133 | LIN54 | lin-54 DREAM MuvB core complex component | ![]() |
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2 | 4 | ||||||
MIRT494946 | IFFO2 | intermediate filament family orphan 2 | ![]() |
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2 | 2 | ||||||
MIRT497403 | NPY4R | neuropeptide Y receptor Y4 | ![]() |
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2 | 2 | ||||||
MIRT497641 | GLDN | gliomedin | ![]() |
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2 | 2 | ||||||
MIRT505340 | TMEM245 | transmembrane protein 245 | ![]() |
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2 | 6 | ||||||
MIRT505680 | SESTD1 | SEC14 and spectrin domain containing 1 | ![]() |
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2 | 6 | ||||||
MIRT510706 | SREK1IP1 | SREK1 interacting protein 1 | ![]() |
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2 | 6 | ||||||
MIRT512198 | C1orf43 | chromosome 1 open reading frame 43 | ![]() |
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2 | 2 | ||||||
MIRT522089 | NUFIP2 | NUFIP2, FMR1 interacting protein 2 | ![]() |
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2 | 4 | ||||||
MIRT525074 | FRK | fyn related Src family tyrosine kinase | ![]() |
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2 | 2 | ||||||
MIRT531276 | PPIL3 | peptidylprolyl isomerase like 3 | ![]() |
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2 | 2 | ||||||
MIRT535119 | PLXNA2 | plexin A2 | ![]() |
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2 | 2 | ||||||
MIRT540836 | GNAT1 | G protein subunit alpha transducin 1 | ![]() |
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2 | 4 | ||||||
MIRT541018 | WIPI2 | WD repeat domain, phosphoinositide interacting 2 | ![]() |
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2 | 2 | ||||||
MIRT545752 | CA12 | carbonic anhydrase 12 | ![]() |
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2 | 4 | ||||||
MIRT546404 | SRP9 | signal recognition particle 9 | ![]() |
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2 | 2 | ||||||
MIRT547991 | HCFC2 | host cell factor C2 | ![]() |
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2 | 4 | ||||||
MIRT554502 | SAE1 | SUMO1 activating enzyme subunit 1 | ![]() |
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2 | 2 | ||||||
MIRT558360 | DMTF1 | cyclin D binding myb like transcription factor 1 | ![]() |
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2 | 2 | ||||||
MIRT558863 | CD2AP | CD2 associated protein | ![]() |
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2 | 2 | ||||||
MIRT559939 | ZNF567 | zinc finger protein 567 | ![]() |
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2 | 2 | ||||||
MIRT566300 | PPM1A | protein phosphatase, Mg2+/Mn2+ dependent 1A | ![]() |
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2 | 2 | ||||||
MIRT567490 | FOXK1 | forkhead box K1 | ![]() |
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2 | 2 | ||||||
MIRT617139 | ZNF556 | zinc finger protein 556 | ![]() |
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2 | 2 | ||||||
MIRT625400 | AKR7L | aldo-keto reductase family 7 like (gene/pseudogene) | ![]() |
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2 | 2 | ||||||
MIRT626491 | CEP89 | centrosomal protein 89 | ![]() |
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2 | 2 | ||||||
MIRT629487 | GSN | gelsolin | ![]() |
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2 | 4 | ||||||
MIRT638456 | PLXDC2 | plexin domain containing 2 | ![]() |
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2 | 2 | ||||||
MIRT648498 | CMBL | carboxymethylenebutenolidase homolog | ![]() |
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2 | 2 | ||||||
MIRT654845 | PPM1L | protein phosphatase, Mg2+/Mn2+ dependent 1L | ![]() |
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2 | 2 | ||||||
MIRT664587 | HSD17B12 | hydroxysteroid 17-beta dehydrogenase 12 | ![]() |
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2 | 2 | ||||||
MIRT664977 | TDRD1 | tudor domain containing 1 | ![]() |
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2 | 2 | ||||||
MIRT665028 | ELK1 | ELK1, ETS transcription factor | ![]() |
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2 | 2 | ||||||
MIRT666043 | STON2 | stonin 2 | ![]() |
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2 | 2 | ||||||
MIRT668863 | CRY2 | cryptochrome circadian clock 2 | ![]() |
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2 | 2 | ||||||
MIRT669297 | C17orf85 | nuclear cap binding subunit 3 | ![]() |
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2 | 2 | ||||||
MIRT680975 | DCAF17 | DDB1 and CUL4 associated factor 17 | ![]() |
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2 | 2 | ||||||
MIRT682267 | RS1 | retinoschisin 1 | ![]() |
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2 | 2 | ||||||
MIRT685283 | KIAA1143 | KIAA1143 | ![]() |
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2 | 2 | ||||||
MIRT693375 | PIGP | phosphatidylinositol glycan anchor biosynthesis class P | ![]() |
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2 | 2 | ||||||
MIRT701785 | MSL1 | male specific lethal 1 homolog | ![]() |
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2 | 2 | ||||||
MIRT709373 | SPECC1 | sperm antigen with calponin homology and coiled-coil domains 1 | ![]() |
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2 | 2 | ||||||
MIRT715154 | IL12B | interleukin 12B | ![]() |
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2 | 2 | ||||||
MIRT734499 | ADAMTS5 | ADAM metallopeptidase with thrombospondin type 1 motif 5 | ![]() |
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3 | 0 |
miRNA-Drug Associations | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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miRNA-Drug Resistance Associations | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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