pre-miRNA Information | |
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pre-miRNA | hsa-mir-4753 |
Genomic Coordinates | chr1: 235190034 - 235190116 |
Description | Homo sapiens miR-4753 stem-loop |
Comment | None |
RNA Secondary Structure | ![]() |
Mature miRNA Information | ||||||||||||||||||||||
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Mature miRNA | hsa-miR-4753-5p | |||||||||||||||||||||
Sequence | 10| CAAGGCCAAAGGAAGAGAACAG |31 | |||||||||||||||||||||
Evidence | Experimental | |||||||||||||||||||||
Experiments | Illumina | |||||||||||||||||||||
SNPs in miRNA |
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Putative Targets |
miRNA Expression profile | |
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Human miRNA Tissue Atlas | |
Circulating MicroRNA Expression Profiling |
Gene Information | |||||||||||||||||||||
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Gene Symbol | KLHL26 | ||||||||||||||||||||
Synonyms | - | ||||||||||||||||||||
Description | kelch like family member 26 | ||||||||||||||||||||
Transcript | NM_018316 | ||||||||||||||||||||
Expression | |||||||||||||||||||||
Putative miRNA Targets on KLHL26 | |||||||||||||||||||||
3'UTR of KLHL26 (miRNA target sites are highlighted) |
>KLHL26|NM_018316|3'UTR 1 CCCCCAAGACCCCCGGGACCCTGGCCTGACCGCATGTTGTCTCCAAGTGGGGCTTGGCGAATGCACGTCTGCCTGAGAAC 81 CCCAGTGCCCCCCTTCGCCCGGGCTGCCCTTGAGGGGCCTGCTGCGTTGATAAGCCCCCCTCCCAGGGGTCCCTCCCTCC 161 CTCCTTCCCAAAGCAGATCCTGGCTGCGAGTCCATCCGAGGGAGCCTGCCGGCAAAGCGTCTGACATGTGGTGGCAGCAA 241 ATTCGTCCCCGGGGTGGTTTCCTCGCCTGGCCCCCGAGTCCCCACGGGCTGGCGGGTGGAATCCCAGGTCTCCAGGGGGT 321 CCCTGTGCAGCTCCATCTCACTTCTCTACTGCCTCCCAGCCCCACGGTTTCAGGCATTCAGATGTGAGCTCATCAACATT 401 GAACCCAAAGTCGGTGGTATATGACTCACCCTCCTTCCAAGTCTCCTGCGCGCGTGTTTTTAAAATAAACTCACCCGAAA 481 CGTCCGTAACACACGGACCTCCAGGAGCAGTGAGAGGTGGCTTAGAAGCCCCTGGTTTGGGGTGGGTGGAGGAGGAGGGC 561 ACGTGTCTGCCTCCCCTGGGGTGCCCTCCTTCCCCCATCCCAAGCTGCTGAGGGGAGGCCCTGGTCATGCCTCAGTTCCT 641 GCCTTCATCTGCTTTCCGGAGGAAAAACCATATCAACTCCTAGAAACGCTCCTTAGGGGCTTGGGACCTTCCATTTGGCA 721 CTGAGCATCTTGTGGGGCCTTAACTGGCTGAGACATCCCGGCCCTCTACATTTGCCCTGTTGGCCAGGCAGTCCCCTTCC 801 CGCAATTGGAGGGCGACGCTAACTTCAGAATCCCATAGTGGCGCTTGCCGCAGGTCTGGTGGGGTGTCTTTTTTCTCCTC 881 CCTCCTTTCCACCCCTCCGCGCCCTGCCACTCCCTGGCCTGCCCTGTTTTTGGGTCAACATTGCTACGGAGCCAGCAGTG 961 AGGCCTTTCCCTTCAAGGGCTCTGTGGTATCTCTGGCCACATTTGTTCTAATGTCTGAACCTCTAAATCTTTTCTTTTTG 1041 ATTGGTTTTACTGTTTTTAAGAAGCCAGCACTGCTGTCTCATAGATGGGATTTGTACTCTTGGGGCAACTTAAAGTGTCT 1121 CTCTCGCTGCTAACAGACGATTGATGTCTTGTCTCTGTGACCCACTCACCATGTAAAGAATTAACCTCCTATCTTAGCAG 1201 ACATCGTCTCCTAATATTTCCCTTTATTTAATAAAAATGTTATGGTGAAGAGATAAAAAAAAAAAAAAAA Target sites
Provided by authors
Predicted by miRanda
DRVs
SNPs
DRVs & SNPs
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miRNA-target interactions (Predicted by miRanda) |
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DRVs in gene 3'UTRs | |||||||||||||||||||||
SNPs in gene 3'UTRs |
Experimental Support 1 for Functional miRNA-Target Interaction | |||||||
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miRNA:Target | ---- | ||||||
Validation Method |
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Conditions | Hela | ||||||
Location of target site | 3'UTR | ||||||
Tools used in this research | TargetScan , miRTarCLIP , Piranha | ||||||
Original Description (Extracted from the article) |
...
HITS-CLIP data was present in GSM1048187. RNA binding protein: AGO2. Condition:Hela_AGO2_CLIP_control
... - Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al., 2013, Cell. |
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miRNA-target interactions (Provided by authors) |
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Article |
- Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al. - Cell, 2013
The induction of pluripotency or trans-differentiation of one cell type to another can be accomplished with cell-lineage-specific transcription factors. Here, we report that repression of a single RNA binding polypyrimidine-tract-binding (PTB) protein, which occurs during normal brain development via the action of miR-124, is sufficient to induce trans-differentiation of fibroblasts into functional neurons. Besides its traditional role in regulated splicing, we show that PTB has a previously undocumented function in the regulation of microRNA functions, suppressing or enhancing microRNA targeting by competitive binding on target mRNA or altering local RNA secondary structure. A key event during neuronal induction is the relief of PTB-mediated blockage of microRNA action on multiple components of the REST complex, thereby derepressing a large array of neuronal genes, including miR-124 and multiple neuronal-specific transcription factors, in nonneuronal cells. This converts a negative feedback loop to a positive one to elicit cellular reprogramming to the neuronal lineage.
LinkOut: [PMID: 23313552]
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CLIP-seq Support 1 for dataset GSM1048187 | |
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Method / RBP | HITS-CLIP / AGO2 |
Cell line / Condition | Hela / Hela_AGO2_CLIP_control |
Location of target site | ENST00000300976.4 | 3UTR | UUCACCAUGUUGGCCAGGCUGGCCUUGA |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 23313552 / GSE42701 |
CLIP-seq Viewer | Link |
MiRNA-Target Expression Profile | |||||||
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MiRNA-Target Expression Profile (TCGA) | |||||||
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94 hsa-miR-4753-5p Target Genes:
Functional analysis:
ID![]() |
Target | Description | Validation methods |
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Strong evidence | Less strong evidence | |||||||||||
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MIRT064916 | ZBTB18 | zinc finger and BTB domain containing 18 | ![]() |
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2 | 2 | ||||||
MIRT161166 | SLC25A36 | solute carrier family 25 member 36 | ![]() |
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2 | 2 | ||||||
MIRT285542 | CDT1 | chromatin licensing and DNA replication factor 1 | ![]() |
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2 | 2 | ||||||
MIRT308266 | LRIG1 | leucine rich repeats and immunoglobulin like domains 1 | ![]() |
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2 | 2 | ||||||
MIRT311425 | LMNB1 | lamin B1 | ![]() |
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2 | 2 | ||||||
MIRT373989 | PEBP1 | phosphatidylethanolamine binding protein 1 | ![]() |
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2 | 4 | ||||||
MIRT383141 | CRY2 | cryptochrome circadian clock 2 | ![]() |
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2 | 2 | ||||||
MIRT405243 | ADIPOR2 | adiponectin receptor 2 | ![]() |
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2 | 2 | ||||||
MIRT441620 | ROCK1 | Rho associated coiled-coil containing protein kinase 1 | ![]() |
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2 | 6 | ||||||
MIRT441789 | SRPK1 | SRSF protein kinase 1 | ![]() |
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2 | 2 | ||||||
MIRT441804 | NOC3L | NOC3 like DNA replication regulator | ![]() |
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2 | 2 | ||||||
MIRT441832 | ALG14 | ALG14, UDP-N-acetylglucosaminyltransferase subunit | ![]() |
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2 | 2 | ||||||
MIRT442005 | NDUFV3 | NADH:ubiquinone oxidoreductase subunit V3 | ![]() |
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2 | 2 | ||||||
MIRT442411 | LIMD1 | LIM domains containing 1 | ![]() |
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2 | 2 | ||||||
MIRT442708 | UBE4B | ubiquitination factor E4B | ![]() |
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2 | 2 | ||||||
MIRT442714 | TNRC6B | trinucleotide repeat containing 6B | ![]() |
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2 | 2 | ||||||
MIRT442738 | SERINC5 | serine incorporator 5 | ![]() |
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2 | 2 | ||||||
MIRT442793 | CEP170 | centrosomal protein 170 | ![]() |
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2 | 2 | ||||||
MIRT442984 | ZNF736 | zinc finger protein 736 | ![]() |
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2 | 2 | ||||||
MIRT443055 | THRB | thyroid hormone receptor beta | ![]() |
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2 | 2 | ||||||
MIRT443288 | ZC3H12A | zinc finger CCCH-type containing 12A | ![]() |
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2 | 2 | ||||||
MIRT443325 | SLC35G1 | solute carrier family 35 member G1 | ![]() |
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2 | 2 | ||||||
MIRT443331 | OCRL | OCRL, inositol polyphosphate-5-phosphatase | ![]() |
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2 | 2 | ||||||
MIRT443593 | ZNF439 | zinc finger protein 439 | ![]() |
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2 | 4 | ||||||
MIRT443696 | KCNN3 | potassium calcium-activated channel subfamily N member 3 | ![]() |
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2 | 2 | ||||||
MIRT443748 | ELL2 | elongation factor for RNA polymerase II 2 | ![]() |
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2 | 2 | ||||||
MIRT443866 | HDLBP | high density lipoprotein binding protein | ![]() |
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2 | 2 | ||||||
MIRT461185 | LTBP2 | latent transforming growth factor beta binding protein 2 | ![]() |
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2 | 2 | ||||||
MIRT464074 | WAC | WW domain containing adaptor with coiled-coil | ![]() |
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2 | 2 | ||||||
MIRT468738 | SDC4 | syndecan 4 | ![]() |
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2 | 2 | ||||||
MIRT470540 | COASY | Coenzyme A synthase | ![]() |
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2 | 2 | ||||||
MIRT476458 | GBA2 | glucosylceramidase beta 2 | ![]() |
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2 | 2 | ||||||
MIRT479470 | CDK6 | cyclin dependent kinase 6 | ![]() |
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2 | 2 | ||||||
MIRT486351 | TACC2 | transforming acidic coiled-coil containing protein 2 | ![]() |
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2 | 8 | ||||||
MIRT495126 | CXorf67 | chromosome X open reading frame 67 | ![]() |
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2 | 2 | ||||||
MIRT495166 | CNGA2 | cyclic nucleotide gated channel alpha 2 | ![]() |
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2 | 4 | ||||||
MIRT495432 | ATG7 | autophagy related 7 | ![]() |
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2 | 2 | ||||||
MIRT495922 | FBXO41 | F-box protein 41 | ![]() |
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2 | 2 | ||||||
MIRT496572 | DGCR6L | DiGeorge syndrome critical region gene 6 like | ![]() |
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2 | 2 | ||||||
MIRT498277 | POFUT1 | protein O-fucosyltransferase 1 | ![]() |
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2 | 2 | ||||||
MIRT498431 | DDX39A | DExD-box helicase 39A | ![]() |
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2 | 2 | ||||||
MIRT530149 | HADHB | hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit | ![]() |
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2 | 2 | ||||||
MIRT530313 | TNFRSF10D | TNF receptor superfamily member 10d | ![]() |
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2 | 2 | ||||||
MIRT530880 | TRUB1 | TruB pseudouridine synthase family member 1 | ![]() |
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2 | 4 | ||||||
MIRT531177 | ZNF626 | zinc finger protein 626 | ![]() |
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2 | 2 | ||||||
MIRT533395 | TYRP1 | tyrosinase related protein 1 | ![]() |
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2 | 2 | ||||||
MIRT533709 | TMEM64 | transmembrane protein 64 | ![]() |
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2 | 2 | ||||||
MIRT533954 | TAF1D | TATA-box binding protein associated factor, RNA polymerase I subunit D | ![]() |
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2 | 2 | ||||||
MIRT535616 | NSD1 | nuclear receptor binding SET domain protein 1 | ![]() |
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2 | 2 | ||||||
MIRT539472 | ADARB2 | adenosine deaminase, RNA specific B2 (inactive) | ![]() |
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2 | 2 | ||||||
MIRT542878 | NR6A1 | nuclear receptor subfamily 6 group A member 1 | ![]() |
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2 | 2 | ||||||
MIRT559077 | C19orf47 | chromosome 19 open reading frame 47 | ![]() |
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2 | 2 | ||||||
MIRT559465 | ARPP19 | cAMP regulated phosphoprotein 19 | ![]() |
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2 | 2 | ||||||
MIRT561233 | ZNF772 | zinc finger protein 772 | ![]() |
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2 | 2 | ||||||
MIRT563477 | POLE3 | DNA polymerase epsilon 3, accessory subunit | ![]() |
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2 | 2 | ||||||
MIRT563995 | SLFN11 | schlafen family member 11 | ![]() |
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2 | 2 | ||||||
MIRT564222 | SDE2 | SDE2 telomere maintenance homolog | ![]() |
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2 | 2 | ||||||
MIRT566017 | RHOA | ras homolog family member A | ![]() |
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2 | 2 | ||||||
MIRT566028 | RFX1 | regulatory factor X1 | ![]() |
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2 | 2 | ||||||
MIRT566591 | NUFIP2 | NUFIP2, FMR1 interacting protein 2 | ![]() |
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2 | 2 | ||||||
MIRT567874 | CTDSP1 | CTD small phosphatase 1 | ![]() |
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2 | 2 | ||||||
MIRT568552 | AKT2 | AKT serine/threonine kinase 2 | ![]() |
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2 | 2 | ||||||
MIRT569357 | EFHC1 | EF-hand domain containing 1 | ![]() |
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2 | 2 | ||||||
MIRT569973 | DNAAF2 | dynein axonemal assembly factor 2 | ![]() |
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2 | 2 | ||||||
MIRT614423 | ZNF440 | zinc finger protein 440 | ![]() |
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2 | 2 | ||||||
MIRT628831 | SLC25A34 | solute carrier family 25 member 34 | ![]() |
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2 | 2 | ||||||
MIRT630142 | ZFYVE9 | zinc finger FYVE-type containing 9 | ![]() |
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2 | 2 | ||||||
MIRT634479 | PAFAH1B2 | platelet activating factor acetylhydrolase 1b catalytic subunit 2 | ![]() |
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2 | 2 | ||||||
MIRT634498 | OR7D2 | olfactory receptor family 7 subfamily D member 2 | ![]() |
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2 | 2 | ||||||
MIRT637394 | R3HDM2 | R3H domain containing 2 | ![]() |
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2 | 2 | ||||||
MIRT641840 | TCF7L2 | transcription factor 7 like 2 | ![]() |
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2 | 2 | ||||||
MIRT644397 | CDKL1 | cyclin dependent kinase like 1 | ![]() |
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2 | 2 | ||||||
MIRT644888 | C2orf50 | chromosome 2 open reading frame 50 | ![]() |
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2 | 2 | ||||||
MIRT647124 | ZNF446 | zinc finger protein 446 | ![]() |
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2 | 2 | ||||||
MIRT647420 | SSTR3 | somatostatin receptor 3 | ![]() |
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2 | 2 | ||||||
MIRT650297 | PYCARD | PYD and CARD domain containing | ![]() |
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2 | 2 | ||||||
MIRT655488 | PAK3 | p21 (RAC1) activated kinase 3 | ![]() |
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2 | 2 | ||||||
MIRT658185 | FBXO9 | F-box protein 9 | ![]() |
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2 | 2 | ||||||
MIRT660931 | ADAM19 | ADAM metallopeptidase domain 19 | ![]() |
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2 | 2 | ||||||
MIRT665317 | ZBTB3 | zinc finger and BTB domain containing 3 | ![]() |
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2 | 2 | ||||||
MIRT670350 | C1orf106 | chromosome 1 open reading frame 106 | ![]() |
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2 | 4 | ||||||
MIRT670823 | NICN1 | nicolin 1 | ![]() |
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2 | 2 | ||||||
MIRT671825 | TRPM6 | transient receptor potential cation channel subfamily M member 6 | ![]() |
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2 | 2 | ||||||
MIRT672732 | NETO2 | neuropilin and tolloid like 2 | ![]() |
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2 | 2 | ||||||
MIRT674841 | GLRX2 | glutaredoxin 2 | ![]() |
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2 | 2 | ||||||
MIRT675930 | CYP51A1 | cytochrome P450 family 51 subfamily A member 1 | ![]() |
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2 | 2 | ||||||
MIRT686786 | AZF1 | azoospermia factor 1 | ![]() |
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2 | 2 | ||||||
MIRT697723 | USP8 | ubiquitin specific peptidase 8 | ![]() |
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2 | 2 | ||||||
MIRT702357 | KLHL26 | kelch like family member 26 | ![]() |
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2 | 2 | ||||||
MIRT704361 | DBR1 | debranching RNA lariats 1 | ![]() |
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2 | 2 | ||||||
MIRT709242 | RANGAP1 | Ran GTPase activating protein 1 | ![]() |
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2 | 2 | ||||||
MIRT714433 | SNED1 | sushi, nidogen and EGF like domains 1 | ![]() |
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2 | 2 | ||||||
MIRT717000 | ARL6IP4 | ADP ribosylation factor like GTPase 6 interacting protein 4 | ![]() |
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2 | 2 | ||||||
MIRT720875 | ADCY5 | adenylate cyclase 5 | ![]() |
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2 | 2 |
miRNA-Drug Resistance Associations | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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