pre-miRNA Information
pre-miRNA hsa-mir-4457   
Genomic Coordinates chr5: 1309310 - 1309377
Description Homo sapiens miR-4457 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4457
Sequence 43| UCACAAGGUAUUGACUGGCGUA |64
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1031676297 8 dbSNP
rs1249861366 14 dbSNP
rs115769169 17 dbSNP
rs968846507 19 dbSNP
rs540870271 20 dbSNP
rs993130937 22 dbSNP
Putative Targets

Gene Information
Gene Symbol ITGA3   
Synonyms CD49C, FRP-2, GAP-B3, GAPB3, ILNEB, MSK18, VCA-2, VL3A, VLA3a
Description integrin subunit alpha 3
Transcript NM_002204   
Expression
Putative miRNA Targets on ITGA3
3'UTR of ITGA3
(miRNA target sites are highlighted)
>ITGA3|NM_002204|3'UTR
   1 GGGGGCAGCCCCCCGCCCCCGGCCCACCTGGTGTGACTTCTTTAAGCGGACCCGCTATTATCAGATCATGCCCAAGTACC
  81 ACGCAGTGCGGATCCGGGAGGAGGAGCGCTACCCACCTCCAGGGAGCACCCTGCCCACCAAGAAGCACTGGGTGACCAGC
 161 TGGCAGACTCGGGACCAATACTACTGACGTCCTCCCTGATCCCACCCCCTCCTCCCCCAGTGTCCCCTTTCTTCCTATTT
 241 ATCATAAGTTATGCCTCTGACAGTCCACAGGGGCCACCACCTTTGGCTGGTAGCAGCAGGCTCAGGCACATACACCTCGT
 321 CAAGAGCATGCACATGCTGTCTGGCCCTGGGGATCTTCCCACAGGAGGGCCAGCGCTGTGGACCTTACAACGCCGAGTGC
 401 ACTGCATTCCTGTGCCCTAGATGCACGTGGGGCCCACTGCTCGTGGACTGTGCTGGTGCATCACGGATGGTGCATGGGCT
 481 CGCCGTGTCTCAGCCTCTGCCAGCGCCAAAACAAGCCAAAGAGCCTCCCACCAGAGCCGGGAGGAAAAGGCCCCTGCAAT
 561 GTGGTGACACCTCCCCCTTTCACACTGGATCCATCTTGAGCCACAGTCACTGGATTGACTTTGCTGTCAAAACTACTGAC
 641 AGGGAGCAGCCCCCGGGCCGCTGGCTGGTGGGCCCCCAATGACACCCATGCCAGAGAGGTGGGGATCCTGCCTAAGGTTG
 721 TCTACGGGGGCACTTGGAGGACCTGGCGTGCTCAGACCCAACAGCAAAGGAACTAGAAAGAAGGACCCAGAACGGCTTGC
 801 TTTCCTGCATCTCTGTGAAGCCTCTCTCCTTGGCCACAGACTGAACTCGCAGGGAATGCAGCAGGAAGGAACAAAGACAG
 881 GCAAACGGCAACGTAGCCTGGGCTCACTGTGCTGGGGCACGGCGGGATCCTCCACAGAGAGGAGGGGACCAATTCTGGAC
 961 AGACAGATGTTGGGAGGATACAGAGGAGATGCCACTTCTCACTCACCACTACCAGCCAGCCTCAGAAGGCCCCAGAGAGA
1041 CCCTGCAAGACCACGGAGGGAGCGACACTTGAATGTAGAATAGGCAGGGGGCCCTGCCCCACCCCATCCAGCCAGACCCC
1121 ACGCTGACCATGCGTCAGGGGCCTAGAGGTGGAGTTCTTAGCTATCCTTGGCTTTCAGAGCCAGCCTGGCTCTGCCCCCT
1201 CCCCCATGGGCTGTGTCCTAAGGCCCATTTGAGAAGCTGAGGCTAGTTCCAGAAAACCTCTCCTGACCCCTGCCTGTTGG
1281 CAGGCCCACTCCCCAGCCCCAGCCCCTTCCATGGTACTGTAGCAGGGGAATTCCCTCCCCCTCCTTGTGCCTTCTTTGTA
1361 TATAGGCTTCTCACGGCGACCAATAAACAGCTCCCAGTTTGTATGCAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' augcggucaguuauGGAACACu 5'
                        ||||||| 
Target 5' aattccctccccctCCTTGTGc 3'
1329 - 1350 140.00 -10.59
2
miRNA  3' auGCGGUCAGUUAUGGAACACu 5'
            | ||:| |   |||| ||| 
Target 5' gcCCCCGGCC--CACCTGGTGt 3'
15 - 34 120.00 -11.20
3
miRNA  3' augCGGUCAGUUA--UGGAAC-ACu 5'
             |:|| | :||  ||:||| || 
Target 5' acaGTCACTGGATTGACTTTGCTGt 3'
603 - 627 113.00 -11.00
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
1198819 15 ClinVar
1028890 792 ClinVar
COSN18740258 6 COSMIC
COSN6105510 63 COSMIC
COSN26744581 213 COSMIC
COSN25771571 362 COSMIC
COSN23781621 413 COSMIC
COSN17378362 489 COSMIC
COSM5018919 787 COSMIC
COSM7757665 789 COSMIC
COSM8910900 791 COSMIC
COSM7757228 792 COSMIC
COSM980918 792 COSMIC
COSM8987208 796 COSMIC
COSM980920 798 COSMIC
COSM9752418 811 COSMIC
COSM7176344 814 COSMIC
COSM5953173 824 COSMIC
COSM1479709 825 COSMIC
COSM7601700 833 COSMIC
COSM8591529 834 COSMIC
COSM7741942 837 COSMIC
COSM5095048 838 COSMIC
COSM7165634 838 COSMIC
COSM6687836 840 COSMIC
COSM9411328 840 COSMIC
COSM6687864 851 COSMIC
COSM2698833 852 COSMIC
COSM4970419 855 COSMIC
COSM6687855 866 COSMIC
COSM8797015 866 COSMIC
COSM5456630 867 COSMIC
COSM6056259 868 COSMIC
COSM6238568 871 COSMIC
COSM7702867 886 COSMIC
COSM8172911 888 COSMIC
COSM9088414 890 COSMIC
COSM5386646 901 COSMIC
COSM8809104 910 COSMIC
COSM7661608 911 COSMIC
COSM980922 915 COSMIC
COSN30665807 933 COSMIC
COSN31493203 933 COSMIC
COSN30523204 936 COSMIC
COSN30482922 979 COSMIC
COSN18741120 1023 COSMIC
COSN30498166 1060 COSMIC
COSN30109978 1071 COSMIC
COSN16414250 1226 COSMIC
COSN28645458 1282 COSMIC
COSN31534019 1331 COSMIC
COSN31543866 1387 COSMIC
COSN26569253 1735 COSMIC
COSN9670144 1797 COSMIC
COSN28871937 1808 COSMIC
COSN15668369 1836 COSMIC
COSN26442099 1877 COSMIC
COSN28191807 1943 COSMIC
COSN8603353 1983 COSMIC
COSN31958063 2066 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1473391903 1 dbSNP
rs762763548 3 dbSNP
rs1478007891 4 dbSNP
rs1046368733 6 dbSNP
rs1260726964 9 dbSNP
rs1362727937 10 dbSNP
rs770875789 14 dbSNP
rs187586850 15 dbSNP
rs1046136111 16 dbSNP
rs1164932823 17 dbSNP
rs200945844 18 dbSNP
rs767496110 21 dbSNP
rs140614661 22 dbSNP
rs1316317163 23 dbSNP
rs1325517335 28 dbSNP
rs1372625455 32 dbSNP
rs996718391 39 dbSNP
rs537255369 40 dbSNP
rs1306333580 42 dbSNP
rs1341147129 43 dbSNP
rs760907255 46 dbSNP
rs1282931081 47 dbSNP
rs764402692 50 dbSNP
rs1053309919 51 dbSNP
rs1277275413 52 dbSNP
rs893322258 54 dbSNP
rs1402598850 57 dbSNP
rs370675762 60 dbSNP
rs1011730083 61 dbSNP
rs1168054461 62 dbSNP
rs954925221 65 dbSNP
rs1008598307 66 dbSNP
rs1014593017 74 dbSNP
rs961829434 77 dbSNP
rs1022048222 78 dbSNP
rs888831054 80 dbSNP
rs1338272124 82 dbSNP
rs1271837242 86 dbSNP
rs751880156 92 dbSNP
rs1007261297 95 dbSNP
rs372987155 97 dbSNP
rs920305459 100 dbSNP
rs958579264 101 dbSNP
rs1019026401 104 dbSNP
rs1379793923 110 dbSNP
rs752058635 131 dbSNP
rs145664995 141 dbSNP
rs1436336744 142 dbSNP
rs917202165 144 dbSNP
rs571326192 147 dbSNP
rs539396072 152 dbSNP
rs1046420532 169 dbSNP
rs971966037 175 dbSNP
rs1382104223 178 dbSNP
rs1026163545 183 dbSNP
rs951882550 188 dbSNP
rs201300663 193 dbSNP
rs377428643 194 dbSNP
rs761280205 204 dbSNP
rs1291438337 206 dbSNP
rs916030773 208 dbSNP
rs1393839081 215 dbSNP
rs1310703331 219 dbSNP
rs1238392158 224 dbSNP
rs1334098080 225 dbSNP
rs1325641447 228 dbSNP
rs935297664 237 dbSNP
rs948812623 239 dbSNP
rs1422591790 240 dbSNP
rs893858470 241 dbSNP
rs1159128661 246 dbSNP
rs981489430 252 dbSNP
rs928607187 268 dbSNP
rs1469156011 271 dbSNP
rs934619214 274 dbSNP
rs996383862 276 dbSNP
rs539139288 283 dbSNP
rs1053384890 284 dbSNP
rs1200402590 288 dbSNP
rs1480527254 300 dbSNP
rs1267818981 301 dbSNP
rs1428785664 310 dbSNP
rs1308094679 323 dbSNP
rs757589632 330 dbSNP
rs1412385284 338 dbSNP
rs1051021959 345 dbSNP
rs1349186155 347 dbSNP
rs893354848 349 dbSNP
rs1234067183 360 dbSNP
rs1345117163 363 dbSNP
rs947589590 365 dbSNP
rs541735275 367 dbSNP
rs1281685184 368 dbSNP
rs1402851692 372 dbSNP
rs1340421351 382 dbSNP
rs138235186 385 dbSNP
rs1318763268 388 dbSNP
rs1399992606 389 dbSNP
rs76174824 392 dbSNP
rs1173816140 396 dbSNP
rs1469919626 408 dbSNP
rs1015146109 411 dbSNP
rs541609870 414 dbSNP
rs1007706011 421 dbSNP
rs961714549 426 dbSNP
rs1243005699 428 dbSNP
rs1192933508 433 dbSNP
rs547446168 436 dbSNP
rs1275629914 437 dbSNP
rs1281436974 441 dbSNP
rs17702032 443 dbSNP
rs111623280 445 dbSNP
rs1220653486 450 dbSNP
rs754643340 453 dbSNP
rs993083542 458 dbSNP
rs1362948568 462 dbSNP
rs1255362062 485 dbSNP
rs1270496911 487 dbSNP
rs750143447 490 dbSNP
rs1189358874 491 dbSNP
rs1336143363 493 dbSNP
rs1452689190 496 dbSNP
rs951955663 501 dbSNP
rs1404666639 518 dbSNP
rs755754811 519 dbSNP
rs1371187989 521 dbSNP
rs765962420 525 dbSNP
rs544436233 526 dbSNP
rs991371711 539 dbSNP
rs1023201266 543 dbSNP
rs753638182 544 dbSNP
rs1419791448 553 dbSNP
rs1167698334 559 dbSNP
rs536295513 560 dbSNP
rs1474667115 568 dbSNP
rs928680763 583 dbSNP
rs971164613 584 dbSNP
rs1184797914 587 dbSNP
rs1472788154 589 dbSNP
rs1461289329 592 dbSNP
rs1184137493 594 dbSNP
rs564346003 594 dbSNP
rs1200618197 598 dbSNP
rs1308232070 606 dbSNP
rs191147499 617 dbSNP
rs1213748877 618 dbSNP
rs183445123 627 dbSNP
rs754764598 628 dbSNP
rs16948664 633 dbSNP
rs528489079 637 dbSNP
rs1397189911 639 dbSNP
rs1334035548 651 dbSNP
rs935351410 654 dbSNP
rs576709603 655 dbSNP
rs368769659 659 dbSNP
rs944194518 660 dbSNP
rs1040100677 664 dbSNP
rs1444502539 670 dbSNP
rs1383930101 675 dbSNP
rs568229573 687 dbSNP
rs530980437 697 dbSNP
rs570878348 703 dbSNP
rs901565300 705 dbSNP
rs1453561388 707 dbSNP
rs757317021 712 dbSNP
rs1344645986 723 dbSNP
rs1483803535 726 dbSNP
rs550788105 727 dbSNP
rs757611909 729 dbSNP
rs1423900316 732 dbSNP
rs898057920 738 dbSNP
rs1224949249 739 dbSNP
rs779462913 746 dbSNP
rs781323996 748 dbSNP
rs56377302 755 dbSNP
rs570792852 757 dbSNP
rs780865641 759 dbSNP
rs1372214337 760 dbSNP
rs747758147 762 dbSNP
rs373467006 763 dbSNP
rs562407766 764 dbSNP
rs749092639 772 dbSNP
rs201407665 774 dbSNP
rs774274614 775 dbSNP
rs78434961 777 dbSNP
rs1229815140 778 dbSNP
rs1300216359 779 dbSNP
rs1340481129 782 dbSNP
rs1420236492 785 dbSNP
rs1224716233 790 dbSNP
rs146403036 791 dbSNP
rs139083066 792 dbSNP
rs1479089963 793 dbSNP
rs149890427 795 dbSNP
rs764280092 796 dbSNP
rs754066272 797 dbSNP
rs1189144159 798 dbSNP
rs762235699 801 dbSNP
rs765525653 805 dbSNP
rs970314414 807 dbSNP
rs1169565592 812 dbSNP
rs1378391002 814 dbSNP
rs770152853 815 dbSNP
rs376978425 826 dbSNP
rs780812895 827 dbSNP
rs752227368 831 dbSNP
rs755739947 833 dbSNP
rs777559611 834 dbSNP
rs748894708 835 dbSNP
rs757016367 839 dbSNP
rs144922409 840 dbSNP
rs745776474 842 dbSNP
rs1297689272 845 dbSNP
rs555469830 851 dbSNP
rs200123319 852 dbSNP
rs1208874040 856 dbSNP
rs369580507 857 dbSNP
rs1384143556 858 dbSNP
rs988850991 860 dbSNP
rs1454708422 863 dbSNP
rs776848685 864 dbSNP
rs756259623 865 dbSNP
rs761956618 866 dbSNP
rs1157005153 868 dbSNP
rs778106113 872 dbSNP
rs200402571 873 dbSNP
rs773484423 877 dbSNP
rs914560759 878 dbSNP
rs969027996 888 dbSNP
rs373731525 893 dbSNP
rs149061589 896 dbSNP
rs1343930328 899 dbSNP
rs752176009 900 dbSNP
rs755614897 905 dbSNP
rs763708067 910 dbSNP
rs1188062691 912 dbSNP
rs753479348 914 dbSNP
rs1280959910 918 dbSNP
rs1344556545 919 dbSNP
rs1213020777 921 dbSNP
rs756888856 922 dbSNP
rs1269524841 923 dbSNP
rs778666178 925 dbSNP
rs745628533 928 dbSNP
rs758248243 931 dbSNP
rs377598451 932 dbSNP
rs142148059 933 dbSNP
rs1268437644 934 dbSNP
rs1298094262 935 dbSNP
rs1473062988 938 dbSNP
rs1041186871 940 dbSNP
rs1184379285 941 dbSNP
rs1383190637 947 dbSNP
rs749364744 948 dbSNP
rs776598172 950 dbSNP
rs749700208 952 dbSNP
rs1352177631 953 dbSNP
rs1287677619 954 dbSNP
rs371189836 955 dbSNP
rs1484639528 958 dbSNP
rs1175829076 963 dbSNP
rs929039299 965 dbSNP
rs1187758284 968 dbSNP
rs1375008118 974 dbSNP
rs915227795 981 dbSNP
rs769879018 982 dbSNP
rs111406341 985 dbSNP
rs1260932233 986 dbSNP
rs769045230 993 dbSNP
rs1462615124 996 dbSNP
rs1487292634 997 dbSNP
rs1243157448 1006 dbSNP
rs986221935 1008 dbSNP
rs1459694017 1021 dbSNP
rs540108856 1025 dbSNP
rs1044708606 1027 dbSNP
rs768273689 1029 dbSNP
rs1307322861 1036 dbSNP
rs1293920441 1051 dbSNP
rs1248749402 1052 dbSNP
rs1384204869 1057 dbSNP
rs1002742740 1062 dbSNP
rs1450627072 1063 dbSNP
rs911951694 1071 dbSNP
rs143201722 1072 dbSNP
rs944875508 1073 dbSNP
rs1036515606 1079 dbSNP
rs1372238528 1083 dbSNP
rs1166497099 1089 dbSNP
rs1179113025 1109 dbSNP
rs528441163 1118 dbSNP
rs1163204773 1119 dbSNP
rs898112280 1124 dbSNP
rs930888435 1133 dbSNP
rs891910478 1135 dbSNP
rs374403365 1136 dbSNP
rs185004383 1138 dbSNP
rs530943927 1139 dbSNP
rs1012555883 1144 dbSNP
rs1024026641 1145 dbSNP
rs985441525 1151 dbSNP
rs1018975242 1153 dbSNP
rs965653894 1157 dbSNP
rs976911926 1159 dbSNP
rs148272574 1171 dbSNP
rs114760470 1173 dbSNP
rs115727254 1174 dbSNP
rs116048089 1176 dbSNP
rs908922971 1186 dbSNP
rs1286574028 1187 dbSNP
rs1394612331 1194 dbSNP
rs1349790599 1200 dbSNP
rs567171975 1202 dbSNP
rs1228990565 1206 dbSNP
rs367903198 1208 dbSNP
rs1028209433 1209 dbSNP
rs1269955216 1210 dbSNP
rs774762738 1216 dbSNP
rs62060012 1220 dbSNP
rs144830874 1222 dbSNP
rs112898874 1225 dbSNP
rs192690149 1226 dbSNP
rs972263411 1228 dbSNP
rs141286743 1229 dbSNP
rs1291653033 1239 dbSNP
rs1220840968 1247 dbSNP
rs1057019437 1248 dbSNP
rs147407544 1249 dbSNP
rs557981640 1253 dbSNP
rs1334187674 1272 dbSNP
rs1285479517 1274 dbSNP
rs3744538 1282 dbSNP
rs1022133620 1283 dbSNP
rs904597475 1293 dbSNP
rs1403481648 1296 dbSNP
rs1387060259 1298 dbSNP
rs1158639609 1308 dbSNP
rs772725782 1312 dbSNP
rs138068637 1314 dbSNP
rs998560304 1317 dbSNP
rs1350652964 1321 dbSNP
rs1268552795 1335 dbSNP
rs1197203550 1341 dbSNP
rs1052764750 1345 dbSNP
rs374685432 1354 dbSNP
rs1018255630 1370 dbSNP
rs1412034648 1379 dbSNP
rs965627796 1380 dbSNP
rs1327207788 1384 dbSNP
rs1265109841 1385 dbSNP
rs1224301721 1387 dbSNP
rs1323112307 1394 dbSNP
rs553754630 1396 dbSNP
rs1369962906 1398 dbSNP
rs976985506 1399 dbSNP
rs3207257 1402 dbSNP
rs1011382903 1403 dbSNP
rs951552257 1404 dbSNP
rs3207258 1407 dbSNP
rs3207259 1409 dbSNP
rs1469934442 1411 dbSNP
rs3169779 1416 dbSNP
rs984272735 1418 dbSNP
rs1301638013 1419 dbSNP
rs573905681 1423 dbSNP
rs1313250464 1433 dbSNP
rs1476619691 1442 dbSNP
rs541804138 1444 dbSNP
rs941788343 1455 dbSNP
rs1193048758 1460 dbSNP
rs552126684 1461 dbSNP
rs184580419 1462 dbSNP
rs143547737 1469 dbSNP
rs766054462 1470 dbSNP
rs1341260898 1473 dbSNP
rs1298060942 1474 dbSNP
rs1206706085 1475 dbSNP
rs534759131 1480 dbSNP
rs1362948312 1481 dbSNP
rs945895432 1482 dbSNP
rs1042890928 1484 dbSNP
rs147157543 1486 dbSNP
rs1006961842 1487 dbSNP
rs1040163503 1491 dbSNP
rs545094528 1492 dbSNP
rs1387708761 1503 dbSNP
rs533332742 1506 dbSNP
rs1025860490 1514 dbSNP
rs1235914518 1515 dbSNP
rs1206844019 1516 dbSNP
rs919316868 1527 dbSNP
rs1273363714 1528 dbSNP
rs1204260547 1530 dbSNP
rs547195216 1533 dbSNP
rs560603273 1537 dbSNP
rs1389809239 1538 dbSNP
rs1377756287 1540 dbSNP
rs114060466 1548 dbSNP
rs963489070 1564 dbSNP
rs1443848382 1566 dbSNP
rs560241842 1567 dbSNP
rs948966695 1569 dbSNP
rs1328601876 1585 dbSNP
rs534598571 1586 dbSNP
rs80321467 1592 dbSNP
rs140332297 1593 dbSNP
rs75975416 1594 dbSNP
rs1179043230 1595 dbSNP
rs1220258564 1596 dbSNP
rs1380991320 1597 dbSNP
rs1232580604 1598 dbSNP
rs2078864 1600 dbSNP
rs913189901 1601 dbSNP
rs1049570376 1605 dbSNP
rs1296351003 1625 dbSNP
rs1293705653 1628 dbSNP
rs889739097 1630 dbSNP
rs945926721 1631 dbSNP
rs188103793 1636 dbSNP
rs1225038693 1637 dbSNP
rs1275973869 1649 dbSNP
rs925821076 1662 dbSNP
rs1062484 1664 dbSNP
rs1039793638 1666 dbSNP
rs553965341 1667 dbSNP
rs9909341 1668 dbSNP
rs180727812 1669 dbSNP
rs1436318116 1690 dbSNP
rs952148527 1691 dbSNP
rs1247610948 1696 dbSNP
rs1401408500 1700 dbSNP
rs1407492608 1701 dbSNP
rs1157160270 1703 dbSNP
rs1450398432 1704 dbSNP
rs867305270 1714 dbSNP
rs1226857973 1723 dbSNP
rs556040474 1732 dbSNP
rs985397415 1736 dbSNP
rs1488115905 1737 dbSNP
rs1169714225 1738 dbSNP
rs1244972639 1746 dbSNP
rs887385211 1750 dbSNP
rs777794627 1751 dbSNP
rs560850771 1757 dbSNP
rs1266974840 1760 dbSNP
rs1017577262 1761 dbSNP
rs1226138859 1763 dbSNP
rs1325261028 1766 dbSNP
rs1176655456 1772 dbSNP
rs981668584 1774 dbSNP
rs770890772 1775 dbSNP
rs138312887 1777 dbSNP
rs934348691 1780 dbSNP
rs1432603303 1796 dbSNP
rs988479335 1798 dbSNP
rs1002747295 1799 dbSNP
rs914336845 1807 dbSNP
rs1280746522 1808 dbSNP
rs773536094 1821 dbSNP
rs1223083096 1826 dbSNP
rs1262041559 1830 dbSNP
rs1313325896 1836 dbSNP
rs763401787 1841 dbSNP
rs1219935861 1843 dbSNP
rs1034132090 1847 dbSNP
rs184785077 1848 dbSNP
rs1483483712 1849 dbSNP
rs1422856050 1850 dbSNP
rs1207569940 1855 dbSNP
rs1231194250 1861 dbSNP
rs1206288487 1864 dbSNP
rs189151821 1866 dbSNP
rs564397641 1867 dbSNP
rs1416551918 1870 dbSNP
rs1443381952 1871 dbSNP
rs1163282450 1872 dbSNP
rs1391200496 1874 dbSNP
rs1425848287 1875 dbSNP
rs36103008 1877 dbSNP
rs540455586 1878 dbSNP
rs1359175798 1880 dbSNP
rs1352456383 1883 dbSNP
rs763617149 1885 dbSNP
rs1302958711 1887 dbSNP
rs943821940 1897 dbSNP
rs1040999155 1900 dbSNP
rs1042358 1901 dbSNP
rs1314027689 1902 dbSNP
rs967419071 1908 dbSNP
rs1342630096 1910 dbSNP
rs1216173361 1913 dbSNP
rs1271141717 1920 dbSNP
rs1062541 1921 dbSNP
rs1062542 1923 dbSNP
rs1454704287 1924 dbSNP
rs978718767 1928 dbSNP
rs1245064111 1933 dbSNP
rs993934575 1934 dbSNP
rs1460339447 1936 dbSNP
rs1183522491 1941 dbSNP
rs1302532746 1942 dbSNP
rs549772790 1943 dbSNP
rs1451697587 1947 dbSNP
rs942556915 1949 dbSNP
rs756840406 1951 dbSNP
rs1409058260 1953 dbSNP
rs1186096215 1962 dbSNP
rs1006309624 1963 dbSNP
rs1312688230 1968 dbSNP
rs1176110757 1971 dbSNP
rs975209399 1973 dbSNP
rs764784003 1993 dbSNP
rs1450289642 2001 dbSNP
rs77335124 2007 dbSNP
rs750143376 2012 dbSNP
rs934059677 2013 dbSNP
rs1047082843 2016 dbSNP
rs1268250875 2017 dbSNP
rs1248227320 2024 dbSNP
rs953695332 2029 dbSNP
rs560779676 2035 dbSNP
rs1383564647 2036 dbSNP
rs117636029 2040 dbSNP
rs181578395 2044 dbSNP
rs1375810465 2054 dbSNP
rs941337917 2056 dbSNP
rs774764500 2058 dbSNP
rs549651988 2060 dbSNP
rs1431307098 2084 dbSNP
rs1038621927 2085 dbSNP
rs1369836955 2091 dbSNP
rs1166593528 2095 dbSNP
rs1158126365 2096 dbSNP
rs1488039161 2110 dbSNP
rs1186230359 2114 dbSNP
rs905432570 2118 dbSNP
rs186717145 2119 dbSNP
rs1482957368 2120 dbSNP
rs981553966 2121 dbSNP
rs1035928112 2122 dbSNP
rs1330202187 2127 dbSNP
rs1002412920 2136 dbSNP
rs1242790107 2138 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions Hela
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1048187. RNA binding protein: AGO2. Condition:Hela_AGO2_CLIP_control ...

- Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al., 2013, Cell.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' augcggucaguuauGGAACACu 5'
                        ||||||| 
Target 5' --uucccucccccuCCUUGUGc 3'
1 - 20
Article - Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al.
- Cell, 2013
The induction of pluripotency or trans-differentiation of one cell type to another can be accomplished with cell-lineage-specific transcription factors. Here, we report that repression of a single RNA binding polypyrimidine-tract-binding (PTB) protein, which occurs during normal brain development via the action of miR-124, is sufficient to induce trans-differentiation of fibroblasts into functional neurons. Besides its traditional role in regulated splicing, we show that PTB has a previously undocumented function in the regulation of microRNA functions, suppressing or enhancing microRNA targeting by competitive binding on target mRNA or altering local RNA secondary structure. A key event during neuronal induction is the relief of PTB-mediated blockage of microRNA action on multiple components of the REST complex, thereby derepressing a large array of neuronal genes, including miR-124 and multiple neuronal-specific transcription factors, in nonneuronal cells. This converts a negative feedback loop to a positive one to elicit cellular reprogramming to the neuronal lineage.
LinkOut: [PMID: 23313552]
CLIP-seq Support 1 for dataset GSM1048187
Method / RBP HITS-CLIP / AGO2
Cell line / Condition Hela / Hela_AGO2_CLIP_control
Location of target site ENST00000007722.7 | 3UTR | UUCCCUCCCCCUCCUUGUGCCUUCUUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23313552 / GSE42701
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
83 hsa-miR-4457 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT098032 SOBP sine oculis binding protein homolog 2 2
MIRT202580 PCMTD2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2 2 6
MIRT247137 WEE1 WEE1 G2 checkpoint kinase 2 4
MIRT349266 PTBP1 polypyrimidine tract binding protein 1 2 2
MIRT363756 EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 2 2
MIRT443586 FAM84B family with sequence similarity 84 member B 2 2
MIRT452333 EIF5AL1 eukaryotic translation initiation factor 5A-like 1 2 2
MIRT453864 ZBTB40 zinc finger and BTB domain containing 40 2 4
MIRT471486 PDE4D phosphodiesterase 4D 2 4
MIRT476290 GMFB glia maturation factor beta 2 8
MIRT479897 CCDC117 coiled-coil domain containing 117 2 4
MIRT484251 ANK1 ankyrin 1 2 2
MIRT491473 TMEM214 transmembrane protein 214 2 2
MIRT493804 GAN gigaxonin 2 6
MIRT499252 VAV3 vav guanine nucleotide exchange factor 3 2 4
MIRT502271 HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 2 4
MIRT504651 RPL9 ribosomal protein L9 2 6
MIRT505211 UBN2 ubinuclein 2 2 8
MIRT508952 SNRPB small nuclear ribonucleoprotein polypeptides B and B1 2 4
MIRT512691 POP1 POP1 homolog, ribonuclease P/MRP subunit 2 2
MIRT513320 SCUBE3 signal peptide, CUB domain and EGF like domain containing 3 2 2
MIRT513870 HOXA5 homeobox A5 2 2
MIRT517342 ZNF529 zinc finger protein 529 2 4
MIRT518947 LSG1 large 60S subunit nuclear export GTPase 1 2 2
MIRT520867 SUGT1 SGT1 homolog, MIS12 kinetochore complex assembly cochaperone 2 2
MIRT528325 GIGYF2 GRB10 interacting GYF protein 2 2 2
MIRT531990 SLCO1B3 solute carrier organic anion transporter family member 1B3 2 2
MIRT533298 USP46 ubiquitin specific peptidase 46 2 2
MIRT545257 TRIM36 tripartite motif containing 36 2 4
MIRT547038 POGZ pogo transposable element derived with ZNF domain 2 2
MIRT556103 MOAP1 modulator of apoptosis 1 2 2
MIRT558321 DR1 down-regulator of transcription 1 2 2
MIRT558521 CSRNP3 cysteine and serine rich nuclear protein 3 2 2
MIRT560906 TMED10 transmembrane p24 trafficking protein 10 2 2
MIRT568448 ARPP19 cAMP regulated phosphoprotein 19 2 2
MIRT570586 OTUD7B OTU deubiquitinase 7B 2 2
MIRT572799 SIGLEC14 sialic acid binding Ig like lectin 14 2 2
MIRT573863 C9orf78 chromosome 9 open reading frame 78 2 2
MIRT575058 P2ry1 purinergic receptor P2Y, G-protein coupled 1 2 5
MIRT609931 SLC38A1 solute carrier family 38 member 1 2 4
MIRT610836 ZNF585A zinc finger protein 585A 2 4
MIRT611474 P2RY1 purinergic receptor P2Y1 2 7
MIRT613569 YY2 YY2 transcription factor 2 2
MIRT618626 GREB1 growth regulation by estrogen in breast cancer 1 2 2
MIRT620606 SAP30 Sin3A associated protein 30 2 2
MIRT621017 CLSTN3 calsyntenin 3 2 4
MIRT635314 FAM179A TOG array regulator of axonemal microtubules 2 2 2
MIRT635919 GLTSCR2 NOP53 ribosome biogenesis factor 2 2
MIRT640598 TM9SF4 transmembrane 9 superfamily member 4 2 2
MIRT641784 YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta 2 4
MIRT644067 IQCE IQ motif containing E 2 2
MIRT648288 TRAPPC2L trafficking protein particle complex 2 like 2 2
MIRT658085 FOXR2 forkhead box R2 2 2
MIRT659077 DEPTOR DEP domain containing MTOR interacting protein 2 2
MIRT665307 ZBTB37 zinc finger and BTB domain containing 37 2 2
MIRT665975 SYTL4 synaptotagmin like 4 2 2
MIRT666302 SLC25A25 solute carrier family 25 member 25 2 2
MIRT674906 RASSF9 Ras association domain family member 9 2 2
MIRT680086 THAP1 THAP domain containing 1 2 2
MIRT681488 DIP2A disco interacting protein 2 homolog A 2 2
MIRT691244 DFNB59 pejvakin 2 2
MIRT692362 AGTRAP angiotensin II receptor associated protein 2 2
MIRT693035 MB21D1 Mab-21 domain containing 1 2 2
MIRT693837 STAT5A signal transducer and activator of transcription 5A 2 2
MIRT694479 LRTOMT leucine rich transmembrane and O-methyltransferase domain containing 2 2
MIRT696070 ZNF264 zinc finger protein 264 2 2
MIRT696578 TTC21B tetratricopeptide repeat domain 21B 2 2
MIRT696760 MTFMT mitochondrial methionyl-tRNA formyltransferase 2 2
MIRT697307 ZNF652 zinc finger protein 652 2 2
MIRT700152 RNF115 ring finger protein 115 2 2
MIRT701056 PARP2 poly(ADP-ribose) polymerase 2 2 2
MIRT701198 OTUD3 OTU deubiquitinase 3 2 2
MIRT701335 NSD1 nuclear receptor binding SET domain protein 1 2 2
MIRT702656 ITGA3 integrin subunit alpha 3 2 2
MIRT703618 FBXO45 F-box protein 45 2 2
MIRT704673 CHTOP chromatin target of PRMT1 2 2
MIRT708894 ZNF780A zinc finger protein 780A 2 2
MIRT711620 DGKH diacylglycerol kinase eta 2 2
MIRT713745 TMEM81 transmembrane protein 81 2 2
MIRT719712 CD101 CD101 molecule 2 2
MIRT720294 DLGAP3 DLG associated protein 3 2 2
MIRT722606 CCDC152 coiled-coil domain containing 152 2 2
MIRT724566 ACSBG1 acyl-CoA synthetase bubblegum family member 1 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-4457 Dabrafenib 44462760 NSC764134 approved sensitive cell line (A375)
hsa-miR-4457 Gefitinib 123631 NSC715055 approved sensitive cell line (PC9)
hsa-miR-4457 Osimertinib 71496458 NSC779217 approved sensitive cell line (PC9)
hsa-miR-4457 Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)

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