pre-miRNA Information | |
---|---|
pre-miRNA | hsa-mir-371b |
Genomic Coordinates | chr19: 53787677 - 53787742 |
Description | Homo sapiens miR-371b stem-loop |
Comment | None |
RNA Secondary Structure | ![]() |
Mature miRNA Information | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mature miRNA | hsa-miR-371b-3p | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sequence | 43| AAGUGCCCCCACAGUUUGAGUGC |65 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
Evidence | Experimental | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
Experiments | Illumina | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
Editing Events in miRNAs |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||
SNPs in miRNA |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||
Putative Targets |
Gene Information | |||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Gene Symbol | IGFBP3 | ||||||||||||||||||||
Synonyms | BP-53, IBP3 | ||||||||||||||||||||
Description | insulin like growth factor binding protein 3 | ||||||||||||||||||||
Transcript | NM_000598 | ||||||||||||||||||||
Other Transcripts | NM_001013398 | ||||||||||||||||||||
Expression | |||||||||||||||||||||
Putative miRNA Targets on IGFBP3 | |||||||||||||||||||||
3'UTR of IGFBP3 (miRNA target sites are highlighted) |
>IGFBP3|NM_000598|3'UTR 1 ACGCCTGCCGCAAGGTTAATGTGGAGCTCAAATATGCCTTATTTTGCACAAAAGACTGCCAAGGACATGACCAGCAGCTG 81 GCTACAGCCTCGATTTATATTTCTGTTTGTGGTGAACTGATTTTTTTTAAACCAAAGTTTAGAAAGAGGTTTTTGAAATG 161 CCTATGGTTTCTTTGAATGGTAAACTTGAGCATCTTTTCACTTTCCAGTAGTCAGCAAAGAGCAGTTTGAATTTTCTTGT 241 CGCTTCCTATCAAAATATTCAGAGACTCGAGCACAGCACCCAGACTTCATGCGCCCGTGGAATGCTCACCACATGTTGGT 321 CGAAGCGGCCGACCACTGACTTTGTGACTTAGGCGGCTGTGTTGCCTATGTAGAGAACACGCTTCACCCCCACTCCCCGT 401 ACAGTGCGCACAGGCTTTATCGAGAATAGGAAAACCTTTAAACCCCGGTCATCCGGACATCCCAACGCATGCTCCTGGAG 481 CTCACAGCCTTCTGTGGTGTCATTTCTGAAACAAGGGCGTGGATCCCTCAACCAAGAAGAATGTTTATGTCTTCAAGTGA 561 CCTGTACTGCTTGGGGACTATTGGAGAAAATAAGGTGGAGTCCTACTTGTTTAAAAAATATGTATCTAAGAATGTTCTAG 641 GGCACTCTGGGAACCTATAAAGGCAGGTATTTCGGGCCCTCCTCTTCAGGAATCTTCCTGAAGACATGGCCCAGTCGAAG 721 GCCCAGGATGGCTTTTGCTGCGGCCCCGTGGGGTAGGAGGGACAGAGAGACAGGGAGAGTCAGCCTCCACATTCAGAGGC 801 ATCACAAGTAATGGCACAATTCTTCGGATGACTGCAGAAAATAGTGTTTTGTAGTTCAACAACTCAAGACGAAGCTTATT 881 TCTGAGGATAAGCTCTTTAAAGGCAAAGCTTTATTTTCATCTCTCATCTTTTGTCCTCCTTAGCACAATGTAAAAAAGAA 961 TAGTAATATCAGAACAGGAAGGAGGAATGGCTTGCTGGGGAGCCCATCCAGGACACTGGGAGCACATAGAGATTCACCCA 1041 TGTTTGTTGAACTTAGAGTCATTCTCATGCTTTTCTTTATAATTCACACATATATGCAGAGAAGATATGTTCTTGTTAAC 1121 ATTGTATACAACATAGCCCCAAATATAGTAAGATCTATACTAGATAATCCTAGATGAAATGTTAGAGATGCTATATGATA 1201 CAACTGTGGCCATGACTGAGGAAAGGAGCTCACGCCCAGAGACTGGGCTGCTCTCCCGGAGGCCAAACCCAAGAAGGTCT 1281 GGCAAAGTCAGGCTCAGGGAGACTCTGCCCTGCTGCAGACCTCGGTGTGGACACACGCTGCATAGAGCTCTCCTTGAAAA 1361 CAGAGGGGTCTCAAGACATTCTGCCTACCTATTAGCTTTTCTTTATTTTTTTAACTTTTTGGGGGGAAAAGTATTTTTGA 1441 GAAGTTTGTCTTGCAATGTATTTATAAATAGTAAATAAAGTTTTTACCATTAAAAAAATATCTTTCCCTTTGTTATTGAC 1521 CATCTCTGGGCTTTGTATCACTAATTATTTTATTTTATTATATAATAATTATTTTATTATAATAAAATCCTGAAAGGGGA 1601 AAATAAAAAAAA Target sites
Provided by authors
Predicted by miRanda
DRVs
SNPs
DRVs & SNPs
|
||||||||||||||||||||
miRNA-target interactions (Predicted by miRanda) |
|
||||||||||||||||||||
DRVs in gene 3'UTRs | |||||||||||||||||||||
SNPs in gene 3'UTRs |
Experimental Support 1 for Functional miRNA-Target Interaction | |||||||
---|---|---|---|---|---|---|---|
miRNA:Target | ---- | ||||||
Validation Method |
|
||||||
Conditions | Hela | ||||||
Location of target site | 3'UTR | ||||||
Tools used in this research | TargetScan , miRTarCLIP , Piranha | ||||||
Original Description (Extracted from the article) |
...
HITS-CLIP data was present in GSM1048187. RNA binding protein: AGO2. Condition:Hela_AGO2_CLIP_control
... - Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al., 2013, Cell. |
||||||
miRNA-target interactions (Provided by authors) |
|
||||||
Article |
- Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al. - Cell, 2013
The induction of pluripotency or trans-differentiation of one cell type to another can be accomplished with cell-lineage-specific transcription factors. Here, we report that repression of a single RNA binding polypyrimidine-tract-binding (PTB) protein, which occurs during normal brain development via the action of miR-124, is sufficient to induce trans-differentiation of fibroblasts into functional neurons. Besides its traditional role in regulated splicing, we show that PTB has a previously undocumented function in the regulation of microRNA functions, suppressing or enhancing microRNA targeting by competitive binding on target mRNA or altering local RNA secondary structure. A key event during neuronal induction is the relief of PTB-mediated blockage of microRNA action on multiple components of the REST complex, thereby derepressing a large array of neuronal genes, including miR-124 and multiple neuronal-specific transcription factors, in nonneuronal cells. This converts a negative feedback loop to a positive one to elicit cellular reprogramming to the neuronal lineage.
LinkOut: [PMID: 23313552]
|
CLIP-seq Support 1 for dataset GSM4903833 | |
---|---|
Method / RBP | HITS-CLIP / AGO |
Cell line / Condition | Dermal fibroblasts / CTL_TD_21_a |
Location of target site | NM_000598 | 3UTR | AAAAUAUGUAUCUAAGAAUGUUCUAGGGCACUCUGGGAACCUAUAAAGGCAGGUAUUUCGGGCCCUCCUCUUCAGGAAUCUUCCUGAAGACAUGGCCCAGUCGAAGGCCCAGGAUGGCUUUUGCUGCGGCCCCGUGGGGUAGGAGGGACAGAGAGACAGGGAGAGUCAGCCUCCACAUUCAGAGGCAUCACAA |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Accession Series | GSE161239 |
CLIP-seq Viewer | Link |
CLIP-seq Support 2 for dataset GSM4903834 | |
---|---|
Method / RBP | HITS-CLIP / AGO |
Cell line / Condition | Dermal fibroblasts / CTL_TD_21_b |
Location of target site | NM_000598 | 3UTR | GUUCUAGGGCACUCUGGGAACCUAUAAAGGCAGGUAUUUCGGGCCCUCCUCUUCAGGAAUCUUCCUGAAGACAUGGCCCAGUCGAAGGCCCAGGAUGGCUUUUGCUGCGGCCCCGUGGGGUAGGAGGGACAGAGAGACAGGGA |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Accession Series | GSE161239 |
CLIP-seq Viewer | Link |
CLIP-seq Support 3 for dataset GSM4903835 | |
---|---|
Method / RBP | HITS-CLIP / AGO |
Cell line / Condition | Dermal fibroblasts / CTL_TD_21_c |
Location of target site | NM_000598 | 3UTR | AAAAUAUGUAUCUAAGAAUGUUCUAGGGCACUCUGGGAACCUAUAAAGGCAGGUAUUUCGGGCCCUCCUCUUCAGGAAUCUUCCUGAAGACAUGGCCCAGUCGAAGGCCCAGGAUGGCUUUUGCUGCGGCCCCGUGGGGUAGGAGGGACAGAGAGACAGGGA |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Accession Series | GSE161239 |
CLIP-seq Viewer | Link |
CLIP-seq Support 4 for dataset GSM4903836 | |
---|---|
Method / RBP | HITS-CLIP / AGO |
Cell line / Condition | Dermal fibroblasts / 124_TD_21_a |
Location of target site | NM_000598 | 3UTR | AUGUUCUAGGGCACUCUGGGAACCUAUAAAGGCAGGUAUUUCGGGCCCUCCUCUUCAGGAAUCUUCCUGAAGACAUGGCCCAGUCGAAGGCCCAGGAUGGCUUUUGCUGCGGCCCCGUGGGGUAGGAGGGACAGAGAGACAGGGA |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Accession Series | GSE161239 |
CLIP-seq Viewer | Link |
CLIP-seq Support 5 for dataset GSM4903837 | |
---|---|
Method / RBP | HITS-CLIP / AGO |
Cell line / Condition | Dermal fibroblasts / 124_TD_21_b |
Location of target site | NM_000598 | 3UTR | UGUUCUAGGGCACUCUGGGAACCUAUAAAGGCAGGUAUUUCGGGCCCUCCUCUUCAGGAAUCUUCCUGAAGACAUGGCCCAGUCGAAGGCCCAGGAUGGCUUUUGCUGCGGCCCCGUGGGGUAGGAGGGACAGAGAGACAGGGA |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Accession Series | GSE161239 |
CLIP-seq Viewer | Link |
CLIP-seq Support 6 for dataset GSM4903838 | |
---|---|
Method / RBP | HITS-CLIP / AGO |
Cell line / Condition | Dermal fibroblasts / 124_TD_21_c |
Location of target site | NM_000598 | 3UTR | UAAGAAUGUUCUAGGGCACUCUGGGAACCUAUAAAGGCAGGUAUUUCGGGCCCUCCUCUUCAGGAAUCUUCCUGAAGACAUGGCCCAGUCGAAGGCCCAGGAUGGCUUUUGCUGCGGCCCCGUGGGGUAGGAGGGACAGAGAGACAGGGAGA |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Accession Series | GSE161239 |
CLIP-seq Viewer | Link |
CLIP-seq Support 7 for dataset GSM1048187 | |
---|---|
Method / RBP | HITS-CLIP / AGO2 |
Cell line / Condition | Hela / Hela_AGO2_CLIP_control |
Location of target site | ENST00000381086.5 | 3UTR | UGUAUCUAAGAAUGUUCUAGGGCACUCUGGGAACC |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 23313552 / GSE42701 |
CLIP-seq Viewer | Link |
MiRNA-Target Expression Profile | |||||||
---|---|---|---|---|---|---|---|
|
MiRNA-Target Expression Profile (TCGA) | |||||||
---|---|---|---|---|---|---|---|
|
42 hsa-miR-371b-3p Target Genes:
Functional analysis:
ID![]() |
Target | Description | Validation methods |
![]() |
![]() |
|||||||
Strong evidence | Less strong evidence | |||||||||||
![]() |
![]() |
![]() |
![]() |
![]() |
![]() |
![]() |
![]() |
|||||
MIRT055410 | SHOC2 | SHOC2, leucine rich repeat scaffold protein | ![]() |
![]() |
2 | 6 | ||||||
MIRT065883 | GDF11 | growth differentiation factor 11 | ![]() |
![]() |
2 | 2 | ||||||
MIRT183507 | BTG2 | BTG anti-proliferation factor 2 | ![]() |
![]() |
2 | 2 | ||||||
MIRT277106 | CDCA8 | cell division cycle associated 8 | ![]() |
![]() |
2 | 2 | ||||||
MIRT300592 | CRKL | CRK like proto-oncogene, adaptor protein | ![]() |
![]() |
2 | 2 | ||||||
MIRT441361 | ZNF75A | zinc finger protein 75a | ![]() |
![]() |
2 | 2 | ||||||
MIRT442692 | COX15 | COX15, cytochrome c oxidase assembly homolog | ![]() |
![]() |
2 | 2 | ||||||
MIRT443388 | CHML | CHM like, Rab escort protein 2 | ![]() |
![]() |
2 | 2 | ||||||
MIRT443571 | EVX2 | even-skipped homeobox 2 | ![]() |
![]() |
2 | 2 | ||||||
MIRT443671 | FLT1 | fms related tyrosine kinase 1 | ![]() |
![]() |
2 | 2 | ||||||
MIRT465524 | PRICKLE4 | prickle planar cell polarity protein 4 | ![]() |
![]() |
2 | 2 | ||||||
MIRT492169 | STAT3 | signal transducer and activator of transcription 3 | ![]() |
![]() |
2 | 2 | ||||||
MIRT496992 | TMEM231 | transmembrane protein 231 | ![]() |
![]() |
2 | 2 | ||||||
MIRT509012 | FBXO6 | F-box protein 6 | ![]() |
![]() |
2 | 2 | ||||||
MIRT509766 | NCAPD2 | non-SMC condensin I complex subunit D2 | ![]() |
![]() |
2 | 2 | ||||||
MIRT514033 | BNIP2 | BCL2 interacting protein 2 | ![]() |
![]() |
2 | 2 | ||||||
MIRT524995 | AFF1 | AF4/FMR2 family member 1 | ![]() |
![]() |
2 | 10 | ||||||
MIRT529899 | C1orf64 | steroid receptor associated and regulated protein | ![]() |
![]() |
2 | 2 | ||||||
MIRT530045 | SMC1A | structural maintenance of chromosomes 1A | ![]() |
![]() |
2 | 2 | ||||||
MIRT534479 | SAR1B | secretion associated Ras related GTPase 1B | ![]() |
![]() |
2 | 2 | ||||||
MIRT535065 | PPP2R5D | protein phosphatase 2 regulatory subunit B'delta | ![]() |
![]() |
2 | 4 | ||||||
MIRT539151 | AREL1 | apoptosis resistant E3 ubiquitin protein ligase 1 | ![]() |
![]() |
2 | 2 | ||||||
MIRT540937 | OIP5 | Opa interacting protein 5 | ![]() |
![]() |
2 | 2 | ||||||
MIRT546360 | SYNM | synemin | ![]() |
![]() |
2 | 2 | ||||||
MIRT553436 | TPM3 | tropomyosin 3 | ![]() |
![]() |
2 | 2 | ||||||
MIRT556278 | MAPK1 | mitogen-activated protein kinase 1 | ![]() |
![]() |
2 | 2 | ||||||
MIRT564092 | NSA2 | NSA2, ribosome biogenesis homolog | ![]() |
![]() |
2 | 2 | ||||||
MIRT568376 | ATXN1 | ataxin 1 | ![]() |
![]() |
2 | 2 | ||||||
MIRT572255 | ANKRD52 | ankyrin repeat domain 52 | ![]() |
![]() |
2 | 2 | ||||||
MIRT572453 | TRIM10 | tripartite motif containing 10 | ![]() |
![]() |
2 | 2 | ||||||
MIRT610741 | NUDT16 | nudix hydrolase 16 | ![]() |
![]() |
2 | 4 | ||||||
MIRT622754 | PHACTR2 | phosphatase and actin regulator 2 | ![]() |
![]() |
2 | 2 | ||||||
MIRT627220 | ZC3H12B | zinc finger CCCH-type containing 12B | ![]() |
![]() |
2 | 2 | ||||||
MIRT629555 | SPN | sialophorin | ![]() |
![]() |
2 | 2 | ||||||
MIRT640288 | MAP3K9 | mitogen-activated protein kinase kinase kinase 9 | ![]() |
![]() |
2 | 2 | ||||||
MIRT651922 | UEVLD | UEV and lactate/malate dehyrogenase domains | ![]() |
![]() |
2 | 2 | ||||||
MIRT684290 | CDK9 | cyclin dependent kinase 9 | ![]() |
![]() |
2 | 2 | ||||||
MIRT700230 | REL | REL proto-oncogene, NF-kB subunit | ![]() |
![]() |
2 | 2 | ||||||
MIRT702748 | IGFBP3 | insulin like growth factor binding protein 3 | ![]() |
![]() |
2 | 2 | ||||||
MIRT711110 | TBC1D21 | TBC1 domain family member 21 | ![]() |
![]() |
2 | 2 | ||||||
MIRT716402 | SEPT5 | septin 5 | ![]() |
![]() |
2 | 2 | ||||||
MIRT723677 | CTC1 | CST telomere replication complex component 1 | ![]() |
![]() |
2 | 2 |
miRNA-Drug Resistance Associations | ||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|