pre-miRNA Information | |
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pre-miRNA | hsa-mir-655 |
Genomic Coordinates | chr14: 101049550 - 101049646 |
Synonyms | MIRN655, hsa-mir-655, MIR655 |
Description | Homo sapiens miR-655 stem-loop |
Comment | None |
RNA Secondary Structure | ![]() |
Associated Diseases | ![]() |
Mature miRNA Information | |||||||||||||||||||||||||||||||
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Mature miRNA | hsa-miR-655-5p | ||||||||||||||||||||||||||||||
Sequence | 23| AGAGGUUAUCCGUGUUAUGUUC |44 | ||||||||||||||||||||||||||||||
Evidence | Experimental | ||||||||||||||||||||||||||||||
Experiments | Illumina | ||||||||||||||||||||||||||||||
SNPs in miRNA |
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Putative Targets |
Gene Information | |||||||||||||||||||||
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Gene Symbol | GOLGA1 | ||||||||||||||||||||
Synonyms | golgin-97 | ||||||||||||||||||||
Description | golgin A1 | ||||||||||||||||||||
Transcript | NM_002077 | ||||||||||||||||||||
Expression | |||||||||||||||||||||
Putative miRNA Targets on GOLGA1 | |||||||||||||||||||||
3'UTR of GOLGA1 (miRNA target sites are highlighted) |
>GOLGA1|NM_002077|3'UTR 1 AGGGGACTACCCAAGGATGGAGCTCCGTGGGTTGACACTTTTTCTGTGAAAAGAACACTGACACACCAGTCTGGGTGGGT 81 TTTTAATCACTGTAACTGCAGTATTTTGTACAAGTGTCTAAACATTGTTTACAAGACTAAGGCCCACTTCCCTGCAGGCT 161 GACCTGAACCTCAGGGGGTAGCTGATCCTGTCATTCTGGTCACCAAACAGGAGGGTCCTGGCACTACCCAGATTTCCACA 241 GTGCTGCTAATATCCCAGCTCCAGCCAGCACCCCATCTGCACCTGAATCCTCTAACTTCACGGTAGCACTTACAGCTGAA 321 GCCATCAGCATCTGGCAGGCACACCTGAGTCACCATGTAGCGCTGCTACTGGAGGTAGAGACGGCCCTTTGAGATGGTGC 401 CCAGCAGGCCAAACCCACCTGCCTCTGCCAGGAACAGCCAACTCCATGGGAACTCTATGGGAGTGGCTTTTAAAAATTCA 481 GATGAGTTAGAAGCTTTTTATCCCTTCCTCTCAAGAAAATATTCTTTCACCCTGTCTCTCAAACCACCTAGAACTTTAGA 561 GGATCCATCTTTAAGGGCCGGTGTGGATGAATGAGAAAATGCACCTTTCTGACAGTATCTCCACTTTACTTAAGAAAACT 641 AGCAAATATATGAAAAGACCCTTAGTACCAAATACACTCAATTGCCTTTTTAATGAATGTACTTGTCTTGGATAGGTTGC 721 TGGTAAACCATTTTAAACTATTTTTTATAGCTGAAGTTCTTCACTACTATAAACATGTCTTCTGTACTATAAAATCCATT 801 TAACTGGTGTTCTTAAAATCAGAGCGTCCAGAGGAAATTCTTCCTAAAACTAGGATTCCTGTTCCTTTGTCTTCTCACTC 881 GCACTCTGGCACTGCTCCCTCTGAAGTGCAGTGGGATCTCGTGTGCTTTGTCTTGATTCTGTGCTGCGCTGCCGCTGGGC 961 GATGCAGACCACCTGTCTTCTACTGAAGGACAGTCCGCTGTCTCCAGTGGGGGCAGCAGCTGTCCCCCAGCCTCGATGGA 1041 GACACTGGGGCAGTCTGCCTTGTCTGTGGAGCTGCTCTCTCTCCCTCATCCCACCCCAAATACTTAAAATGACACTACAC 1121 CCAGACGGCGCCCAGCTGGCTGCAGCACTTGTAGCATGCACATGACTCTGGTAGTAACCAACAAAAACTTGTTTTATGGA 1201 TTCCTCGTTTACTGAGGAAAGGGAACATGCTGGTTCTGGAAAAGCCACAATATTGAATCTAAAAGGAAACCGTTTATTGT 1281 TTGATGAAAGTTTCACTGGTTAAATAAAAAACTAAATTAATAACTGGAGCCTCTAAATTTATTATCCATTATCCAGTGAT 1361 GGAAAGTTGTATTTCTCAATCATGCTTAGGGCCAAAATAGGTATATAAAATGTGTCACAGAAAAACACGCATTTGCAACG 1441 TTAACCTAACGAAATTTCCATGAAGAACCAAGTCAGGGCAGCATCTCCTTAGTCCCAGCTCAGGCTCTCTGCCTTCCAGA 1521 GGCCGCTTCTCCAGTGACTAACCTCCTCCTCTGGCTCCTCCTTGCAGACAGTTATCCCTTGTTTAGAACACGAATTTCCA 1601 TTTACCTGGTGGGAACACGAAACAGGAGTCTCTTCTGTTCTGCAAGTTTGATGGGTAAGAGGTAGCCTTTTTTCAAAGTA 1681 GGATTTCCTTTTTCAACTGTTCCAGGAAAGAATCTCTAAGACTGGGTAGCTCACAGCCAGCCAAAGGCAGCTACATTTCC 1761 ACAGAAGCCCGTCCGCTGCCTCCGTGGCTTCTCCAGCCATTGAACTGGTCCCACACGCACCCCAGGCCCCACTCCTCGGC 1841 AGTTTCAGGTGTAGCTGTGGGGCCCGTTCCTAGGTCTGTACTCACTTTAGGGAGGCTTCACTGACTAGGCTTTCCTCCTG 1921 CATGTTGAATTTCCTTCAGCTTTAAGAGGAAGAGTGGAATAAATATTCTAAGTGATTTAATGCACTTTGACTTGTATAAA 2001 ACTTTCTGTGTTAGCGACGGTATCTATAGCCCTTTATACGAGCGATGGATCTTGAGCTCTCCTTCCATGTTGTAAATAGG 2081 GATTGTATTCTTGAAAACTGCTGTAGCAAATTCATCTGTGGTGCAATACACTTTTTGATTAAAGCTCTTCAATCCAGATG 2161 CAACTACAATGGATTTTACTAGTTTGGTGTGTCAGTATTTCTTTGACTCATTAAATCTGGTATTTTGTGTCTCATAAAAA 2241 AAAAAAAAAAAAA Target sites
Provided by authors
Predicted by miRanda
DRVs
SNPs
DRVs & SNPs
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miRNA-target interactions (Predicted by miRanda) |
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DRVs in gene 3'UTRs | |||||||||||||||||||||
SNPs in gene 3'UTRs |
Experimental Support 1 for Functional miRNA-Target Interaction | |||||||
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miRNA:Target | ---- | ||||||
Validation Method |
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Conditions | Hela | ||||||
Location of target site | 3'UTR | ||||||
Tools used in this research | TargetScan , miRTarCLIP , Piranha | ||||||
Original Description (Extracted from the article) |
...
HITS-CLIP data was present in GSM1048187. RNA binding protein: AGO2. Condition:Hela_AGO2_CLIP_control
... - Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al., 2013, Cell. |
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miRNA-target interactions (Provided by authors) |
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Article |
- Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al. - Cell, 2013
The induction of pluripotency or trans-differentiation of one cell type to another can be accomplished with cell-lineage-specific transcription factors. Here, we report that repression of a single RNA binding polypyrimidine-tract-binding (PTB) protein, which occurs during normal brain development via the action of miR-124, is sufficient to induce trans-differentiation of fibroblasts into functional neurons. Besides its traditional role in regulated splicing, we show that PTB has a previously undocumented function in the regulation of microRNA functions, suppressing or enhancing microRNA targeting by competitive binding on target mRNA or altering local RNA secondary structure. A key event during neuronal induction is the relief of PTB-mediated blockage of microRNA action on multiple components of the REST complex, thereby derepressing a large array of neuronal genes, including miR-124 and multiple neuronal-specific transcription factors, in nonneuronal cells. This converts a negative feedback loop to a positive one to elicit cellular reprogramming to the neuronal lineage.
LinkOut: [PMID: 23313552]
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CLIP-seq Support 1 for dataset GSM1048187 | |
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Method / RBP | HITS-CLIP / AGO2 |
Cell line / Condition | Hela / Hela_AGO2_CLIP_control |
Location of target site | ENST00000373555.4 | 3UTR | ACCUGAACCUCAGGGGGUAGCUGAUCCUGUCAU |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 23313552 / GSE42701 |
CLIP-seq Viewer | Link |
MiRNA-Target Expression Profile | |||||||
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MiRNA-Target Expression Profile (TCGA) | |||||||
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91 hsa-miR-655-5p Target Genes:
Functional analysis:
ID![]() |
Target | Description | Validation methods |
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Strong evidence | Less strong evidence | |||||||||||
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MIRT080691 | KIAA1468 | KIAA1468 | ![]() |
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2 | 2 | ||||||
MIRT095086 | SEC24A | SEC24 homolog A, COPII coat complex component | ![]() |
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2 | 4 | ||||||
MIRT122450 | SMIM13 | small integral membrane protein 13 | ![]() |
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2 | 2 | ||||||
MIRT214635 | SMAD5 | SMAD family member 5 | ![]() |
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2 | 4 | ||||||
MIRT268267 | CCND1 | cyclin D1 | ![]() |
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2 | 2 | ||||||
MIRT312418 | GRPEL2 | GrpE like 2, mitochondrial | ![]() |
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2 | 2 | ||||||
MIRT329008 | DSTN | destrin, actin depolymerizing factor | ![]() |
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2 | 2 | ||||||
MIRT329824 | PDCD4 | programmed cell death 4 | ![]() |
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2 | 4 | ||||||
MIRT389635 | LRRC58 | leucine rich repeat containing 58 | ![]() |
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2 | 6 | ||||||
MIRT443969 | FAM198B | family with sequence similarity 198 member B | ![]() |
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2 | 2 | ||||||
MIRT444080 | C12orf73 | chromosome 12 open reading frame 73 | ![]() |
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2 | 2 | ||||||
MIRT444886 | TMEM196 | transmembrane protein 196 | ![]() |
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2 | 2 | ||||||
MIRT445506 | CRNKL1 | crooked neck pre-mRNA splicing factor 1 | ![]() |
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2 | 4 | ||||||
MIRT446292 | ACSL3 | acyl-CoA synthetase long chain family member 3 | ![]() |
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2 | 2 | ||||||
MIRT446462 | THAP1 | THAP domain containing 1 | ![]() |
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2 | 2 | ||||||
MIRT446472 | THUMPD3 | THUMP domain containing 3 | ![]() |
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2 | 2 | ||||||
MIRT447413 | MED21 | mediator complex subunit 21 | ![]() |
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2 | 2 | ||||||
MIRT447491 | KIAA1715 | lunapark, ER junction formation factor | ![]() |
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2 | 2 | ||||||
MIRT448965 | CDADC1 | cytidine and dCMP deaminase domain containing 1 | ![]() |
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2 | 2 | ||||||
MIRT449602 | INIP | INTS3 and NABP interacting protein | ![]() |
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2 | 2 | ||||||
MIRT449607 | PRPF4 | pre-mRNA processing factor 4 | ![]() |
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2 | 2 | ||||||
MIRT449737 | TAB2 | TGF-beta activated kinase 1/MAP3K7 binding protein 2 | ![]() |
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2 | 2 | ||||||
MIRT451668 | KRT8 | keratin 8 | ![]() |
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2 | 4 | ||||||
MIRT452424 | QDPR | quinoid dihydropteridine reductase | ![]() |
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2 | 2 | ||||||
MIRT455187 | AGTRAP | angiotensin II receptor associated protein | ![]() |
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2 | 2 | ||||||
MIRT456059 | SLC25A28 | solute carrier family 25 member 28 | ![]() |
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2 | 2 | ||||||
MIRT456488 | SERAC1 | serine active site containing 1 | ![]() |
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2 | 2 | ||||||
MIRT456631 | ARMCX6 | armadillo repeat containing, X-linked 6 | ![]() |
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2 | 2 | ||||||
MIRT459621 | SLC25A33 | solute carrier family 25 member 33 | ![]() |
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2 | 2 | ||||||
MIRT461162 | SLC11A2 | solute carrier family 11 member 2 | ![]() |
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2 | 4 | ||||||
MIRT461990 | PACSIN1 | protein kinase C and casein kinase substrate in neurons 1 | ![]() |
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2 | 2 | ||||||
MIRT463149 | ZNF385A | zinc finger protein 385A | ![]() |
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2 | 4 | ||||||
MIRT463465 | ZC3HAV1L | zinc finger CCCH-type containing, antiviral 1 like | ![]() |
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2 | 2 | ||||||
MIRT463801 | XPOT | exportin for tRNA | ![]() |
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2 | 2 | ||||||
MIRT464010 | WDR26 | WD repeat domain 26 | ![]() |
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2 | 2 | ||||||
MIRT465302 | TRIB1 | tribbles pseudokinase 1 | ![]() |
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2 | 2 | ||||||
MIRT468837 | RRM2 | ribonucleotide reductase regulatory subunit M2 | ![]() |
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2 | 2 | ||||||
MIRT469132 | RNF126 | ring finger protein 126 | ![]() |
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2 | 2 | ||||||
MIRT469244 | RHOB | ras homolog family member B | ![]() |
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2 | 2 | ||||||
MIRT472414 | NCKAP1 | NCK associated protein 1 | ![]() |
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2 | 2 | ||||||
MIRT472432 | NCBP2 | nuclear cap binding protein subunit 2 | ![]() |
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2 | 2 | ||||||
MIRT472808 | MTMR12 | myotubularin related protein 12 | ![]() |
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2 | 2 | ||||||
MIRT477893 | DVL3 | dishevelled segment polarity protein 3 | ![]() |
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2 | 4 | ||||||
MIRT477963 | DPM2 | dolichyl-phosphate mannosyltransferase subunit 2, regulatory | ![]() |
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2 | 2 | ||||||
MIRT479258 | CHSY1 | chondroitin sulfate synthase 1 | ![]() |
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2 | 2 | ||||||
MIRT479718 | CCNF | cyclin F | ![]() |
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2 | 2 | ||||||
MIRT480231 | C9orf41 | carnosine N-methyltransferase 1 | ![]() |
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2 | 2 | ||||||
MIRT482600 | ABHD14B | abhydrolase domain containing 14B | ![]() |
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2 | 2 | ||||||
MIRT483096 | TFPI | tissue factor pathway inhibitor | ![]() |
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2 | 2 | ||||||
MIRT484644 | TBC1D5 | TBC1 domain family member 5 | ![]() |
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2 | 4 | ||||||
MIRT488899 | CLDND1 | claudin domain containing 1 | ![]() |
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2 | 2 | ||||||
MIRT491954 | VPS52 | VPS52, GARP complex subunit | ![]() |
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2 | 2 | ||||||
MIRT496937 | LBR | lamin B receptor | ![]() |
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2 | 2 | ||||||
MIRT498546 | TMEM30B | transmembrane protein 30B | ![]() |
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2 | 2 | ||||||
MIRT501778 | NRBF2 | nuclear receptor binding factor 2 | ![]() |
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2 | 6 | ||||||
MIRT516286 | DBT | dihydrolipoamide branched chain transacylase E2 | ![]() |
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2 | 2 | ||||||
MIRT516351 | GABPB1 | GA binding protein transcription factor beta subunit 1 | ![]() |
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2 | 2 | ||||||
MIRT516751 | ZNF100 | zinc finger protein 100 | ![]() |
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2 | 2 | ||||||
MIRT517939 | ZNF431 | zinc finger protein 431 | ![]() |
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2 | 4 | ||||||
MIRT518295 | ZNF514 | zinc finger protein 514 | ![]() |
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2 | 4 | ||||||
MIRT518515 | CASP10 | caspase 10 | ![]() |
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2 | 2 | ||||||
MIRT519017 | NOA1 | nitric oxide associated 1 | ![]() |
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2 | 2 | ||||||
MIRT519171 | SCO1 | SCO1, cytochrome c oxidase assembly protein | ![]() |
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2 | 2 | ||||||
MIRT519470 | SPTLC2 | serine palmitoyltransferase long chain base subunit 2 | ![]() |
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2 | 2 | ||||||
MIRT521029 | SLC30A5 | solute carrier family 30 member 5 | ![]() |
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2 | 2 | ||||||
MIRT521251 | SAMD8 | sterile alpha motif domain containing 8 | ![]() |
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2 | 2 | ||||||
MIRT521682 | PRKAR2A | protein kinase cAMP-dependent type II regulatory subunit alpha | ![]() |
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2 | 2 | ||||||
MIRT529386 | SKP1 | S-phase kinase associated protein 1 | ![]() |
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2 | 2 | ||||||
MIRT545507 | NAP1L1 | nucleosome assembly protein 1 like 1 | ![]() |
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2 | 2 | ||||||
MIRT549655 | RSL1D1 | ribosomal L1 domain containing 1 | ![]() |
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2 | 2 | ||||||
MIRT551041 | CTSB | cathepsin B | ![]() |
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2 | 4 | ||||||
MIRT551441 | ZNF490 | zinc finger protein 490 | ![]() |
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2 | 4 | ||||||
MIRT554778 | RHEBP1 | RHEB pseudogene 1 | ![]() |
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2 | 4 | ||||||
MIRT565793 | SEC14L5 | SEC14 like lipid binding 5 | ![]() |
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2 | 2 | ||||||
MIRT566727 | MSL2 | MSL complex subunit 2 | ![]() |
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2 | 2 | ||||||
MIRT574668 | HNRNPDL | heterogeneous nuclear ribonucleoprotein D like | ![]() |
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2 | 2 | ||||||
MIRT610128 | DENND5B | DENN domain containing 5B | ![]() |
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2 | 2 | ||||||
MIRT624919 | FBXW2 | F-box and WD repeat domain containing 2 | ![]() |
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2 | 2 | ||||||
MIRT641830 | TRIM71 | tripartite motif containing 71 | ![]() |
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2 | 2 | ||||||
MIRT662165 | IFNAR2 | interferon alpha and beta receptor subunit 2 | ![]() |
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2 | 2 | ||||||
MIRT667150 | NRXN3 | neurexin 3 | ![]() |
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2 | 2 | ||||||
MIRT689085 | ADNP2 | ADNP homeobox 2 | ![]() |
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2 | 2 | ||||||
MIRT696322 | DCAF15 | DDB1 and CUL4 associated factor 15 | ![]() |
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2 | 2 | ||||||
MIRT699062 | SNX4 | sorting nexin 4 | ![]() |
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2 | 2 | ||||||
MIRT703229 | GOLGA1 | golgin A1 | ![]() |
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2 | 2 | ||||||
MIRT705743 | AMD1 | adenosylmethionine decarboxylase 1 | ![]() |
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2 | 2 | ||||||
MIRT706087 | HNRNPU | heterogeneous nuclear ribonucleoprotein U | ![]() |
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2 | 2 | ||||||
MIRT709288 | MAPK8IP2 | mitogen-activated protein kinase 8 interacting protein 2 | ![]() |
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2 | 2 | ||||||
MIRT711457 | RNF145 | ring finger protein 145 | ![]() |
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2 | 2 | ||||||
MIRT714708 | PPP3CC | protein phosphatase 3 catalytic subunit gamma | ![]() |
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2 | 2 | ||||||
MIRT719871 | CYP4F11 | cytochrome P450 family 4 subfamily F member 11 | ![]() |
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2 | 2 |
miRNA-Drug Associations | ||||||||||||||||||
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miRNA-Drug Resistance Associations | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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