pre-miRNA Information
pre-miRNA hsa-mir-4291   
Genomic Coordinates chr9: 93819357 - 93819421
Description Homo sapiens miR-4291 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4291
Sequence 11| UUCAGCAGGAACAGCU |26
Evidence Experimental
Experiments SOLiD
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1265713434 9 dbSNP
rs1433969451 12 dbSNP
rs1372852268 16 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol GDPD5   
Synonyms GDE2, PP1665
Description glycerophosphodiester phosphodiesterase domain containing 5
Transcript NM_030792   
Expression
Putative miRNA Targets on GDPD5
3'UTR of GDPD5
(miRNA target sites are highlighted)
>GDPD5|NM_030792|3'UTR
   1 CTGAAGACATGTCTGTCCCACCTGTACCTGACACAGAAGCTGGGGAGCCTAGGAGAGCTGGTGGAAGTGTGTCTGAACTC
  81 GGAGTGCTCTGGGAGCGGGCTCCACAGCCTCCTTGTGGGCTCCAGCCCCTTGTCAGCCGCAGCCTCTCTTGAGGGGGACT
 161 CCCTGTCTCCTGAGGCCCAGCTGGGCCAGGACTCCATCCTTTCAGATGCCCCTGCAGGCCTGGGGCTCCTTCTGGGAAGT
 241 ATGGGGCCTAGGGCTTGGTCCCCCTCTTCTGAGGCCCTCTCCTGTATCCCGACCTGGAAGCTTTGATGGGTCATGGGCCA
 321 TGCCATACCCCCTGTGGCAATGGAGTGTGTGGATGCTCACCTGTGCCATCTGTCCTCCTGTCTGTGCCAGGAGGCACCTG
 401 AGTTCTCTGCTGTTATCCTGCCCCAAGGGCCTGGGCCGAGCCTCTACCTGAAGCAACTCTGCTCTTCCTGTCAGTCTCAA
 481 AGCACAAGGAGGTTCAGCCCAGGAGGAAGCCAGCTGCAATGTGGAGACACGTCCTCCTCCCCAACCCACCTCATGCCACC
 561 GCCAACCCCCTGCCCCAGGAGCGGGCCTGAGCCACGTCCCCTAGGAGCAGCTGGAGATGGCCAAAAGAGTGAGCTCAGGA
 641 CTACTGGATCCCATGCCCAGGTGTCCAGCAGACCTCAAGGCAGAAGGGTCACCTAACCCAGGAGTCCACAGACTGATGTG
 721 ACCTCAGGTTCCCACATCAGTGGCCACAGGGCAGGGCCCACCTGGTAGAAGTGTTCTGGATATGGCCAGGGTGGGTGTGT
 801 GGCTAAGTGGGCCTGAACAGAGGGAACCTAGGGCCCTTGGCCAATGTGATTAAAGCTGCCATCTTGAAAAAAAAAAAAAA
 881 AAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' ucgaCAAG-GACGACuu 5'
              |||| ||||||  
Target 5' ctgaGTTCTCTGCTGtt 3'
398 - 414 132.00 -13.20
2
miRNA  3' ucGACAAGGACGACUu 5'
            ||||  || |||| 
Target 5' ccCTGT--CTCCTGAg 3'
161 - 174 118.00 -10.24
3
miRNA  3' ucGACAAG-----GACGACUu 5'
            :|| ||     || |||| 
Target 5' gcTTGGTCCCCCTCTTCTGAg 3'
253 - 273 110.00 -5.70
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30476856 18 COSMIC
COSN13350611 19 COSMIC
COSN30454734 19 COSMIC
COSN30156718 30 COSMIC
COSN30474813 43 COSMIC
COSN31580297 45 COSMIC
COSN30528702 48 COSMIC
COSN30477340 60 COSMIC
COSN30477368 61 COSMIC
COSN28848793 66 COSMIC
COSN31778884 81 COSMIC
COSN26977307 83 COSMIC
COSN30486410 127 COSMIC
COSN30542830 155 COSMIC
COSN28649024 168 COSMIC
COSN1542981 185 COSMIC
COSN1137911 264 COSMIC
COSN1137909 322 COSMIC
COSN31546006 352 COSMIC
COSN8584726 418 COSMIC
COSN20899910 583 COSMIC
COSN31516047 634 COSMIC
COSN27133593 855 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1304899773 1 dbSNP
rs1452856128 2 dbSNP
rs750661900 10 dbSNP
rs781332651 11 dbSNP
rs1485636380 16 dbSNP
rs528344017 17 dbSNP
rs757385377 18 dbSNP
rs751633617 22 dbSNP
rs991810972 24 dbSNP
rs764635820 26 dbSNP
rs906047811 27 dbSNP
rs1453675958 31 dbSNP
rs1245592635 32 dbSNP
rs1342281683 33 dbSNP
rs1327965404 34 dbSNP
rs758166903 38 dbSNP
rs1227790431 40 dbSNP
rs1414048568 48 dbSNP
rs183534412 49 dbSNP
rs1224010589 54 dbSNP
rs926838927 57 dbSNP
rs540408478 59 dbSNP
rs1046191051 71 dbSNP
rs968172808 78 dbSNP
rs1264372916 80 dbSNP
rs1352849347 81 dbSNP
rs1383565325 88 dbSNP
rs1446550291 90 dbSNP
rs1168102718 96 dbSNP
rs574893404 111 dbSNP
rs561078577 113 dbSNP
rs1010187248 114 dbSNP
rs1454132952 127 dbSNP
rs1386914992 129 dbSNP
rs1382553455 135 dbSNP
rs544601341 137 dbSNP
rs955475133 138 dbSNP
rs575520727 139 dbSNP
rs558866419 144 dbSNP
rs538826350 149 dbSNP
rs527424229 153 dbSNP
rs974646219 160 dbSNP
rs964493099 161 dbSNP
rs779528500 162 dbSNP
rs1203387235 163 dbSNP
rs1043638 168 dbSNP
rs535938113 175 dbSNP
rs887730578 186 dbSNP
rs1047550776 192 dbSNP
rs1417365146 199 dbSNP
rs1156899380 204 dbSNP
rs966478589 207 dbSNP
rs1454149228 212 dbSNP
rs1335761715 231 dbSNP
rs1403463147 239 dbSNP
rs917655077 246 dbSNP
rs1021162678 247 dbSNP
rs750636453 260 dbSNP
rs1336979989 267 dbSNP
rs368696613 268 dbSNP
rs1010557446 277 dbSNP
rs893489466 288 dbSNP
rs1309819660 290 dbSNP
rs567358812 291 dbSNP
rs1261723193 294 dbSNP
rs1326096237 305 dbSNP
rs1204591647 308 dbSNP
rs1232494064 310 dbSNP
rs1371177650 315 dbSNP
rs1001788960 319 dbSNP
rs1479712647 325 dbSNP
rs1178984298 328 dbSNP
rs765530014 334 dbSNP
rs1435442745 339 dbSNP
rs1377463791 340 dbSNP
rs113813843 344 dbSNP
rs145614431 349 dbSNP
rs926282360 353 dbSNP
rs1176732615 361 dbSNP
rs1353517662 363 dbSNP
rs1439395086 386 dbSNP
rs979638950 386 dbSNP
rs191032786 394 dbSNP
rs1045892245 396 dbSNP
rs1404949396 401 dbSNP
rs1364729229 402 dbSNP
rs571565383 408 dbSNP
rs778298703 410 dbSNP
rs1417823275 425 dbSNP
rs1251788394 430 dbSNP
rs1272604453 431 dbSNP
rs1305915912 437 dbSNP
rs950300934 438 dbSNP
rs1180762985 449 dbSNP
rs1490206890 452 dbSNP
rs1198658556 453 dbSNP
rs111985450 456 dbSNP
rs551730720 459 dbSNP
rs1481312081 464 dbSNP
rs1048309390 467 dbSNP
rs1418362566 469 dbSNP
rs1407913124 472 dbSNP
rs185331322 473 dbSNP
rs930618795 476 dbSNP
rs920615065 481 dbSNP
rs1423429497 485 dbSNP
rs974593849 487 dbSNP
rs371086486 491 dbSNP
rs528282385 492 dbSNP
rs1367959684 499 dbSNP
rs796554337 509 dbSNP
rs776754538 531 dbSNP
rs1269916896 536 dbSNP
rs987319284 539 dbSNP
rs879354539 540 dbSNP
rs767416486 543 dbSNP
rs1020673792 544 dbSNP
rs989652730 552 dbSNP
rs957652549 553 dbSNP
rs1029675528 560 dbSNP
rs866704516 568 dbSNP
rs558340202 574 dbSNP
rs1240964036 575 dbSNP
rs1315008051 577 dbSNP
rs1289507316 579 dbSNP
rs1287683254 581 dbSNP
rs756501608 583 dbSNP
rs1001903426 589 dbSNP
rs10291 595 dbSNP
rs1474286113 596 dbSNP
rs1025000101 599 dbSNP
rs1540214 600 dbSNP
rs944708518 601 dbSNP
rs547927530 602 dbSNP
rs1047785917 604 dbSNP
rs1386001479 610 dbSNP
rs1161059030 619 dbSNP
rs994886726 623 dbSNP
rs899138045 624 dbSNP
rs887689766 628 dbSNP
rs1160633001 630 dbSNP
rs1452107553 633 dbSNP
rs532766941 651 dbSNP
rs61897370 654 dbSNP
rs911795499 655 dbSNP
rs367963035 656 dbSNP
rs896322025 663 dbSNP
rs1056192974 686 dbSNP
rs945206675 688 dbSNP
rs1441450254 694 dbSNP
rs1360246450 698 dbSNP
rs1228858441 699 dbSNP
rs1262023197 702 dbSNP
rs1445086980 716 dbSNP
rs1206634332 720 dbSNP
rs1326822177 723 dbSNP
rs913726712 725 dbSNP
rs1336508051 727 dbSNP
rs937744492 728 dbSNP
rs1181355677 738 dbSNP
rs1386629152 754 dbSNP
rs1472824825 757 dbSNP
rs1267363017 764 dbSNP
rs1233814284 766 dbSNP
rs1336945096 792 dbSNP
rs1402841418 797 dbSNP
rs989195396 799 dbSNP
rs904980729 804 dbSNP
rs1450807729 808 dbSNP
rs1338909145 811 dbSNP
rs1327193462 812 dbSNP
rs957764674 815 dbSNP
rs182657613 816 dbSNP
rs946402628 818 dbSNP
rs1225271551 827 dbSNP
rs1268591895 828 dbSNP
rs79131751 834 dbSNP
rs1201433993 863 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions Hela
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1048187. RNA binding protein: AGO2. Condition:Hela_AGO2_CLIP_control ...

- Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al., 2013, Cell.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' ucgacAAGGACG-ACuu 5'
               ||||||| ||  
Target 5' cgccaUUCCUGCAUGug 3'
20 - 36
2
miRNA  3' ucgACAAGGACGACUu 5'
             | | ||||| |: 
Target 5' --aUCUCCCUGCAGGg 3'
1 - 14
Article - Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al.
- Cell, 2013
The induction of pluripotency or trans-differentiation of one cell type to another can be accomplished with cell-lineage-specific transcription factors. Here, we report that repression of a single RNA binding polypyrimidine-tract-binding (PTB) protein, which occurs during normal brain development via the action of miR-124, is sufficient to induce trans-differentiation of fibroblasts into functional neurons. Besides its traditional role in regulated splicing, we show that PTB has a previously undocumented function in the regulation of microRNA functions, suppressing or enhancing microRNA targeting by competitive binding on target mRNA or altering local RNA secondary structure. A key event during neuronal induction is the relief of PTB-mediated blockage of microRNA action on multiple components of the REST complex, thereby derepressing a large array of neuronal genes, including miR-124 and multiple neuronal-specific transcription factors, in nonneuronal cells. This converts a negative feedback loop to a positive one to elicit cellular reprogramming to the neuronal lineage.
LinkOut: [PMID: 23313552]
CLIP-seq Support 1 for dataset GSM1048187
Method / RBP HITS-CLIP / AGO2
Cell line / Condition Hela / Hela_AGO2_CLIP_control
Location of target site ENST00000443276.2 | 3UTR | aucucccugcagggcacagcgccauuccugcaugugg
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23313552 / GSE42701
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
82 hsa-miR-4291 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT102445 CALU calumenin 2 4
MIRT108677 ZBTB33 zinc finger and BTB domain containing 33 2 4
MIRT125969 SHOC2 SHOC2, leucine rich repeat scaffold protein 2 6
MIRT179018 PAFAH1B2 platelet activating factor acetylhydrolase 1b catalytic subunit 2 2 4
MIRT379033 CDK6 cyclin dependent kinase 6 2 6
MIRT442473 CPEB4 cytoplasmic polyadenylation element binding protein 4 2 2
MIRT442910 PCBD2 pterin-4 alpha-carbinolamine dehydratase 2 2 2
MIRT442979 ZNF736 zinc finger protein 736 2 2
MIRT445663 TNFSF15 TNF superfamily member 15 2 2
MIRT446237 FZD6 frizzled class receptor 6 2 2
MIRT448860 FAM49B family with sequence similarity 49 member B 2 2
MIRT455559 TRAF1 TNF receptor associated factor 1 2 2
MIRT459704 ZNF641 zinc finger protein 641 2 2
MIRT460608 FEM1A fem-1 homolog A 2 2
MIRT462251 LAMA4 laminin subunit alpha 4 2 2
MIRT462469 FIZ1 FLT3 interacting zinc finger 1 2 2
MIRT466656 TAF1D TATA-box binding protein associated factor, RNA polymerase I subunit D 2 6
MIRT466841 STX6 syntaxin 6 2 2
MIRT471403 PDP2 pyruvate dehyrogenase phosphatase catalytic subunit 2 2 2
MIRT471517 PCGF3 polycomb group ring finger 3 2 2
MIRT471681 PABPN1 poly(A) binding protein nuclear 1 2 2
MIRT472858 MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 2 2
MIRT474813 KIAA0226 RUN and cysteine rich domain containing beclin 1 interacting protein 2 2
MIRT474931 KCTD15 potassium channel tetramerization domain containing 15 2 2
MIRT475814 HDGF heparin binding growth factor 2 2
MIRT480434 C17orf49 chromosome 17 open reading frame 49 2 2
MIRT480903 BCL2L2-PABPN1 BCL2L2-PABPN1 readthrough 2 2
MIRT481478 ARL8B ADP ribosylation factor like GTPase 8B 2 2
MIRT484982 UBE2V1 ubiquitin conjugating enzyme E2 V1 2 8
MIRT485019 TMEM189-UBE2V1 TMEM189-UBE2V1 readthrough 2 8
MIRT485036 TMEM189 transmembrane protein 189 2 8
MIRT495074 HEYL hes related family bHLH transcription factor with YRPW motif-like 2 2
MIRT496004 CD180 CD180 molecule 2 2
MIRT500675 TRIM37 tripartite motif containing 37 2 2
MIRT504544 ZNF417 zinc finger protein 417 2 6
MIRT506782 KLHL15 kelch like family member 15 2 6
MIRT507256 FGF2 fibroblast growth factor 2 2 6
MIRT507386 EN2 engrailed homeobox 2 2 2
MIRT512505 BTBD19 BTB domain containing 19 2 2
MIRT516903 CTSB cathepsin B 2 2
MIRT528124 PPP1R10 protein phosphatase 1 regulatory subunit 10 2 2
MIRT528874 ATF3 activating transcription factor 3 2 2
MIRT536091 MBOAT2 membrane bound O-acyltransferase domain containing 2 2 2
MIRT541079 RLIM ring finger protein, LIM domain interacting 2 2
MIRT541099 RAF1 Raf-1 proto-oncogene, serine/threonine kinase 2 2
MIRT545360 LIN7C lin-7 homolog C, crumbs cell polarity complex component 2 2
MIRT545831 ZNF367 zinc finger protein 367 2 4
MIRT547115 PHLPP2 PH domain and leucine rich repeat protein phosphatase 2 2 2
MIRT547312 NPTN neuroplastin 2 2
MIRT547959 HIGD1A HIG1 hypoxia inducible domain family member 1A 2 4
MIRT549943 RPL7L1 ribosomal protein L7 like 1 2 2
MIRT550749 ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1 2 2
MIRT565145 TUBB2A tubulin beta 2A class IIa 2 2
MIRT571050 POLQ DNA polymerase theta 2 2
MIRT571361 ZNF45 zinc finger protein 45 2 2
MIRT610133 FOXI2 forkhead box I2 2 2
MIRT613145 DSE dermatan sulfate epimerase 2 2
MIRT613379 ABCC12 ATP binding cassette subfamily C member 12 2 2
MIRT615752 C6 complement C6 2 2
MIRT616460 ADRA2B adrenoceptor alpha 2B 2 2
MIRT616719 FEM1B fem-1 homolog B 2 2
MIRT618312 IPP intracisternal A particle-promoted polypeptide 2 2
MIRT631491 RASSF4 Ras association domain family member 4 2 2
MIRT643134 PLCXD2 phosphatidylinositol specific phospholipase C X domain containing 2 2 2
MIRT643482 DISC1 disrupted in schizophrenia 1 2 2
MIRT649715 TWSG1 twisted gastrulation BMP signaling modulator 1 2 2
MIRT653542 SLC38A7 solute carrier family 38 member 7 2 2
MIRT666307 SLC22A3 solute carrier family 22 member 3 2 2
MIRT692005 NAP1L4 nucleosome assembly protein 1 like 4 2 2
MIRT696838 ARL2BP ADP ribosylation factor like GTPase 2 binding protein 2 2
MIRT698204 TMEM248 transmembrane protein 248 2 2
MIRT703316 GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 2 2
MIRT709376 FAM13A family with sequence similarity 13 member A 2 2
MIRT710112 MED23 mediator complex subunit 23 2 2
MIRT711975 HOMER2 homer scaffolding protein 2 2 2
MIRT712275 PPIP5K2 diphosphoinositol pentakisphosphate kinase 2 2 2
MIRT714108 TMED9 transmembrane p24 trafficking protein 9 2 2
MIRT719113 MAML1 mastermind like transcriptional coactivator 1 2 2
MIRT719727 SLC39A11 solute carrier family 39 member 11 2 2
MIRT720018 TFAP2C transcription factor AP-2 gamma 2 2
MIRT720358 ZBTB8B zinc finger and BTB domain containing 8B 2 2
MIRT720372 NUDT3 nudix hydrolase 3 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4291 Platinum-based doublet chemotherapy resistant High Lung Adenocarcinoma tissue
hsa-miR-4291 Platinum 23939 resistant High Ovarian Cancer tissue
hsa-miR-4291 Paclitaxel 36314 NSC125973 approved resistant High Prostate Cancer cell line (DU-145, PC-3)
hsa-miR-4291 Doxorubicin 31703 NSC123127 approved resistant High Chronic Myelogenous Leukemia cell line (K562)
hsa-miR-4291 Radioactivity Iodine resistant High Papillary Thyroid Cancer tissue
hsa-miR-4291 Cisplatin 5460033 NSC119875 approved resistant High Hypopharyngeal Cancer cell line (FaDu)
hsa-miR-4291 Gefitinib 123631 NSC715055 approved resistant cell line (PC9)
hsa-miR-4291 Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-4291 Cisplatin 5460033 NSC119875 approved sensitive cell line (CAL-27) (cytosolic RNA)
hsa-miR-4291 Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)
hsa-miR-4291 Platinum-based doublet chemotherapy resistant tissue (lung adenocarcinoma)
hsa-miR-4291 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-4291 Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR3)
hsa-miR-4291 Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR4)

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