pre-miRNA Information | |
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pre-miRNA | hsa-mir-4316 |
Genomic Coordinates | chr17: 77396984 - 77397054 |
Description | Homo sapiens miR-4316 stem-loop |
Comment | None |
RNA Secondary Structure | ![]() |
Mature miRNA Information | ||||||||||
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Mature miRNA | hsa-miR-4316 | |||||||||
Sequence | 11| GGUGAGGCUAGCUGGUG |27 | |||||||||
Evidence | Experimental | |||||||||
Experiments | SOLiD | |||||||||
SNPs in miRNA |
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Putative Targets |
miRNA Expression profile | |
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Human miRNA Tissue Atlas | |
Circulating MicroRNA Expression Profiling |
Gene Information | |||||||||||||||||||||
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Gene Symbol | CCDC120 | ||||||||||||||||||||
Synonyms | JM11 | ||||||||||||||||||||
Description | coiled-coil domain containing 120 | ||||||||||||||||||||
Transcript | NM_001163323 | ||||||||||||||||||||
Other Transcripts | NM_001163322 , NM_001163321 , NM_033626 | ||||||||||||||||||||
Expression | |||||||||||||||||||||
Putative miRNA Targets on CCDC120 | |||||||||||||||||||||
3'UTR of CCDC120 (miRNA target sites are highlighted) |
>CCDC120|NM_001163323|3'UTR 1 TGGGTAGGGGTCTCGTAAGGCAGATGGCGAAGATATCCAGGCCAGGGAGTGGCTAGTCATGATAGCTAATGAATTGGACC 81 ATGAGGAAACTAGCTGCTGTGATGGCACAGGGTCACTCTACTGCACATGACCTGCATTAGTCCATGGGGTCCTGGTGGAG 161 GGGATCTTGGGCACTGGTAGCAGCAATTCTTTATCAAGTTATAGGCTGAAGATGAGCCTTGAAGCCAGGGTGCCGGGAGG 241 AAGGGACATCTCATGCCCCTTGCTGTTTTCTTCCTTTTTTCTCCATGCCCCAGAGCCTGAAAGTGCTGTCCTGTGCCTGC 321 CTCCACCTCTTTAACGAGCCTCTTTTCCTTTCTTTTTCTGTGTCTTGTCTGTCTTTTCTTCTTCTTGTCTTCCCCGCCCT 401 GTCCTCCGGATTCCTGCTACCCCTTCTAAAGATACTACGCGGACTTCCTGTATCCCCCGGAGCTGAGCGCTCGTTTAAGT 481 GACCTGACGCTAGAGGGGGAGCAGTCCTCCAGTTCTGACACCCAGACCCCGGGGACACTGGTCTGACCCCTTCTGATATG 561 TCCCTTGTTGGCCTGGGCACGATTCCAATCTGGGGAGCACACAGCTGACCTCGCTGGGCCCTGGGGTGTGGTTGCTCTCA 641 GTCCTGAGCAGAGTGCGCCAACCTAATCTTCCAAGGCCCCTGGCTCCCCGTAGGCCCAGGAAGGTGTCTGACACCCTGCT 721 TCTTCTCTCACACTGTGCTGGGGACTGGGGGCCCTCAGCTAGCTTAAAAGAGGGGGGATGATGTCATGGGGACCCCAAGC 801 CCCTTCCTCCATTTATGTTTACAGTTGTGACTTAGGTATTCACTGTCTTCCTCCAACACTAGGCGTTTTACAAAAGGGAA 881 ACTGTGATCTCATCTGGTTGGGTTCATTCCTGTTCCCATGCCCAACCAGGTTCCATTCAGGAACCCCCTCCATAAAATGG 961 ACCATATCGGGTCTCAGGGCCATTTAGGGCAGCCAGGAGACTCCGGTGTGAACAGAAATCCCTGCCACGCATCGCCAGGG 1041 CAGTTGGGGCAGTGGGCTCTCTGCCCACACTTGGAAGGACTGCAGTCTGGGTGGGATGCCTGAAAGAGCCCAACCCCCTC 1121 TGTGCCCATGGCCTCTGCCCTGACCACCCCCAGTCAGGAGGCCCCACAGGAGGGGCACCCGGTAGATGCCAGTGAAATCC 1201 TCAGGGGAGGTCTGCCTGAAAGAGCCCAACCCCCTCTGTGCCCATGGCCTCTGCCCTGACCACCCCCAGTCAGGAGGCCC 1281 CACAGGAGGGGCACCCGGTAGATGCCAGTGAAATCCTCAGGTGAGGTCTGCCTACGGGCCACGGGCCACTCACCACTCAC 1361 ACCTTCCTTGGCTTTCCTTCCACCCTTTTTTTTTTCTCGAGACGGAGTCTTGCTCTGTCACCAGGCTGGAGTGCAGCGGC 1441 GCAATCTCAGCTCACTGCAACCTCTGCCTCCTGGGTTCTCCTGCCTCACCCTCCCGAGTAGCTGGGATTACAGGCACACG 1521 CCACCATGCCCGGCTAATTTTTGTATTCTTAGTAGAGACAAGGTTTCACCATATTGGCCAGGCTGGTCTTGAACTCTTGA 1601 CCTCGTGATCTGCCCGCCTTGGCCTCCCAAAGTGCTGGGATTACAGCCGTGAGCCACTGCACCCAGCCCCAATCCACCAC 1681 TTTTTAAGCAAACCCACACAAGTTGTGTTTTCTATGATACCTGTCTGTGATTTTCGGAGCTGGGGGTTCCCCTACCCCCT 1761 TTTCCTGGCGTTAAGCTTTTCTTTTTATACCAGTGGATCTGGACCCAAGACATTACCCACACTGGAAGGGGATTTGTATA 1841 ATAAATGTGTAAACTGAACCCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA Target sites
Provided by authors
Predicted by miRanda
DRVs
SNPs
DRVs & SNPs
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miRNA-target interactions (Predicted by miRanda) |
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SNPs in gene 3'UTRs |
Experimental Support 1 for Functional miRNA-Target Interaction | |||||||
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miRNA:Target | ---- | ||||||
Validation Method |
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Conditions | Hela | ||||||
Location of target site | 3'UTR | ||||||
Tools used in this research | TargetScan , miRTarCLIP , Piranha | ||||||
Original Description (Extracted from the article) |
...
HITS-CLIP data was present in GSM1048187. RNA binding protein: AGO2. Condition:Hela_AGO2_CLIP_control
... - Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al., 2013, Cell. |
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miRNA-target interactions (Provided by authors) |
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Article |
- Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al. - Cell, 2013
The induction of pluripotency or trans-differentiation of one cell type to another can be accomplished with cell-lineage-specific transcription factors. Here, we report that repression of a single RNA binding polypyrimidine-tract-binding (PTB) protein, which occurs during normal brain development via the action of miR-124, is sufficient to induce trans-differentiation of fibroblasts into functional neurons. Besides its traditional role in regulated splicing, we show that PTB has a previously undocumented function in the regulation of microRNA functions, suppressing or enhancing microRNA targeting by competitive binding on target mRNA or altering local RNA secondary structure. A key event during neuronal induction is the relief of PTB-mediated blockage of microRNA action on multiple components of the REST complex, thereby derepressing a large array of neuronal genes, including miR-124 and multiple neuronal-specific transcription factors, in nonneuronal cells. This converts a negative feedback loop to a positive one to elicit cellular reprogramming to the neuronal lineage.
LinkOut: [PMID: 23313552]
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CLIP-seq Support 1 for dataset GSM1048187 | |
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Method / RBP | HITS-CLIP / AGO2 |
Cell line / Condition | Hela / Hela_AGO2_CLIP_control |
Location of target site | ENST00000376396.3 | 3UTR | GGGUUCUCCUGCCUCACCCUC |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 23313552 / GSE42701 |
CLIP-seq Viewer | Link |
MiRNA-Target Expression Profile | |||||||
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MiRNA-Target Expression Profile (TCGA) | |||||||
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74 hsa-miR-4316 Target Genes:
Functional analysis:
ID![]() |
Target | Description | Validation methods |
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Strong evidence | Less strong evidence | |||||||||||
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MIRT080624 | PMAIP1 | phorbol-12-myristate-13-acetate-induced protein 1 | ![]() |
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2 | 2 | ||||||
MIRT095088 | SEC24A | SEC24 homolog A, COPII coat complex component | ![]() |
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2 | 4 | ||||||
MIRT123331 | CALU | calumenin | ![]() |
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2 | 2 | ||||||
MIRT154964 | RRM2 | ribonucleotide reductase regulatory subunit M2 | ![]() |
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2 | 2 | ||||||
MIRT370850 | TGFBR2 | transforming growth factor beta receptor 2 | ![]() |
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2 | 2 | ||||||
MIRT442955 | SGCD | sarcoglycan delta | ![]() |
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2 | 2 | ||||||
MIRT448240 | ZNF774 | zinc finger protein 774 | ![]() |
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2 | 2 | ||||||
MIRT451710 | OLR1 | oxidized low density lipoprotein receptor 1 | ![]() |
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2 | 2 | ||||||
MIRT452072 | ATP6V0B | ATPase H+ transporting V0 subunit b | ![]() |
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2 | 2 | ||||||
MIRT455665 | GLO1 | glyoxalase I | ![]() |
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2 | 2 | ||||||
MIRT460354 | TXNDC16 | thioredoxin domain containing 16 | ![]() |
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2 | 2 | ||||||
MIRT461908 | NECAB3 | N-terminal EF-hand calcium binding protein 3 | ![]() |
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2 | 2 | ||||||
MIRT462047 | HOXC13 | homeobox C13 | ![]() |
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2 | 2 | ||||||
MIRT462735 | EFNB1 | ephrin B1 | ![]() |
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2 | 2 | ||||||
MIRT463409 | ZC3HAV1L | zinc finger CCCH-type containing, antiviral 1 like | ![]() |
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2 | 2 | ||||||
MIRT464952 | TWIST1 | twist family bHLH transcription factor 1 | ![]() |
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2 | 2 | ||||||
MIRT465052 | TSR1 | TSR1, ribosome maturation factor | ![]() |
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2 | 2 | ||||||
MIRT467549 | SMARCD1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 | ![]() |
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2 | 4 | ||||||
MIRT470226 | PRRC2A | proline rich coiled-coil 2A | ![]() |
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2 | 2 | ||||||
MIRT474081 | LMBR1L | limb development membrane protein 1 like | ![]() |
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2 | 2 | ||||||
MIRT474481 | KLHDC8B | kelch domain containing 8B | ![]() |
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2 | 2 | ||||||
MIRT474704 | KIF3A | kinesin family member 3A | ![]() |
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2 | 2 | ||||||
MIRT474897 | KCTD21 | potassium channel tetramerization domain containing 21 | ![]() |
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2 | 2 | ||||||
MIRT475203 | IL2RB | interleukin 2 receptor subunit beta | ![]() |
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2 | 2 | ||||||
MIRT477664 | EFHD2 | EF-hand domain family member D2 | ![]() |
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2 | 2 | ||||||
MIRT477775 | E2F3 | E2F transcription factor 3 | ![]() |
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2 | 2 | ||||||
MIRT477940 | DPM2 | dolichyl-phosphate mannosyltransferase subunit 2, regulatory | ![]() |
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2 | 2 | ||||||
MIRT478224 | DDX52 | DExD-box helicase 52 | ![]() |
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2 | 2 | ||||||
MIRT479904 | CCDC117 | coiled-coil domain containing 117 | ![]() |
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2 | 2 | ||||||
MIRT480639 | BSCL2 | BSCL2, seipin lipid droplet biogenesis associated | ![]() |
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2 | 2 | ||||||
MIRT482435 | ADM | adrenomedullin | ![]() |
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2 | 10 | ||||||
MIRT483908 | GNB1L | G protein subunit beta 1 like | ![]() |
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2 | 2 | ||||||
MIRT484161 | FAM71B | family with sequence similarity 71 member B | ![]() |
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2 | 2 | ||||||
MIRT484405 | SNX19 | sorting nexin 19 | ![]() |
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2 | 2 | ||||||
MIRT485426 | LASP1 | LIM and SH3 protein 1 | ![]() |
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2 | 2 | ||||||
MIRT489788 | KRT80 | keratin 80 | ![]() |
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2 | 4 | ||||||
MIRT490813 | ASB1 | ankyrin repeat and SOCS box containing 1 | ![]() |
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2 | 4 | ||||||
MIRT491176 | LAMA5 | laminin subunit alpha 5 | ![]() |
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2 | 2 | ||||||
MIRT491573 | HSDL1 | hydroxysteroid dehydrogenase like 1 | ![]() |
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2 | 2 | ||||||
MIRT492633 | PLXNA1 | plexin A1 | ![]() |
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2 | 2 | ||||||
MIRT492984 | NAV1 | neuron navigator 1 | ![]() |
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2 | 2 | ||||||
MIRT496441 | RAB11FIP4 | RAB11 family interacting protein 4 | ![]() |
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2 | 2 | ||||||
MIRT501829 | NCOA3 | nuclear receptor coactivator 3 | ![]() |
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2 | 2 | ||||||
MIRT502165 | KIAA0195 | transmembrane protein 94 | ![]() |
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2 | 2 | ||||||
MIRT508652 | DIABLO | diablo IAP-binding mitochondrial protein | ![]() |
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2 | 4 | ||||||
MIRT509554 | ACTG1 | actin gamma 1 | ![]() |
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2 | 4 | ||||||
MIRT520033 | YOD1 | YOD1 deubiquitinase | ![]() |
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2 | 6 | ||||||
MIRT523969 | DVL3 | dishevelled segment polarity protein 3 | ![]() |
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2 | 2 | ||||||
MIRT526150 | KIAA1456 | KIAA1456 | ![]() |
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2 | 2 | ||||||
MIRT530330 | ARHGAP1 | Rho GTPase activating protein 1 | ![]() |
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2 | 2 | ||||||
MIRT539985 | SLC24A4 | solute carrier family 24 member 4 | ![]() |
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2 | 4 | ||||||
MIRT540851 | NUP155 | nucleoporin 155 | ![]() |
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2 | 2 | ||||||
MIRT542326 | LIMD1 | LIM domains containing 1 | ![]() |
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2 | 2 | ||||||
MIRT558908 | CBX5 | chromobox 5 | ![]() |
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2 | 2 | ||||||
MIRT563663 | SMC4 | structural maintenance of chromosomes 4 | ![]() |
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2 | 2 | ||||||
MIRT565433 | SURF4 | surfeit 4 | ![]() |
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2 | 2 | ||||||
MIRT567773 | DGAT2 | diacylglycerol O-acyltransferase 2 | ![]() |
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2 | 2 | ||||||
MIRT615573 | NCS1 | neuronal calcium sensor 1 | ![]() |
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2 | 2 | ||||||
MIRT627336 | TTLL7 | tubulin tyrosine ligase like 7 | ![]() |
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2 | 2 | ||||||
MIRT632965 | EIF2S3 | eukaryotic translation initiation factor 2 subunit gamma | ![]() |
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2 | 2 | ||||||
MIRT634307 | SNTN | sentan, cilia apical structure protein | ![]() |
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2 | 2 | ||||||
MIRT641569 | RAX | retina and anterior neural fold homeobox | ![]() |
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2 | 2 | ||||||
MIRT660509 | ARL5A | ADP ribosylation factor like GTPase 5A | ![]() |
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2 | 2 | ||||||
MIRT662703 | C10orf111 | chromosome 10 open reading frame 111 | ![]() |
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2 | 4 | ||||||
MIRT663214 | ZNF277 | zinc finger protein 277 | ![]() |
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2 | 2 | ||||||
MIRT665318 | YIPF4 | Yip1 domain family member 4 | ![]() |
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2 | 2 | ||||||
MIRT695264 | CD209 | CD209 molecule | ![]() |
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2 | 2 | ||||||
MIRT696231 | LIN9 | lin-9 DREAM MuvB core complex component | ![]() |
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2 | 2 | ||||||
MIRT698867 | SRPR | SRP receptor alpha subunit | ![]() |
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2 | 2 | ||||||
MIRT702700 | IPO9 | importin 9 | ![]() |
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2 | 2 | ||||||
MIRT704236 | DHDDS | dehydrodolichyl diphosphate synthase subunit | ![]() |
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2 | 2 | ||||||
MIRT704935 | CCDC120 | coiled-coil domain containing 120 | ![]() |
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2 | 2 | ||||||
MIRT724285 | KCNMB1 | potassium calcium-activated channel subfamily M regulatory beta subunit 1 | ![]() |
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2 | 2 | ||||||
MIRT735579 | VEGFA | vascular endothelial growth factor A | ![]() |
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3 | 0 |
miRNA-Drug Associations | ||||||||||||||||||
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miRNA-Drug Resistance Associations | ||||||||||||||||||||||||||||||||||||||||
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