pre-miRNA Information
pre-miRNA hsa-mir-4436b-1   
Genomic Coordinates chr2: 110086433 - 110086523
Description Homo sapiens miR-4436b-1 stem-loop
Comment None
RNA Secondary Structure
pre-miRNA hsa-mir-4436b-2   
Genomic Coordinates chr2: 110284853 - 110284943
Description Homo sapiens miR-4436b-2 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4436b-3p
Sequence 60| CAGGGCAGGAAGAAGUGGACAA |81
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs760150076 9 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol ATP1B3   
Synonyms ATPB-3, CD298
Description ATPase Na+/K+ transporting subunit beta 3
Transcript NM_001679   
Expression
Putative miRNA Targets on ATP1B3
3'UTR of ATP1B3
(miRNA target sites are highlighted)
>ATP1B3|NM_001679|3'UTR
   1 TATGAGTAGGATATCTCCACAGAGTAAATGTTGTGTTGTCTGTCTTCATTTTGTAACAGCTGGACCTTCCATTCTAGAAT
  81 TATGAGACCACCTTGGAGAAAGGTGTGTGGTACATGACATTGGGTTACATCATAACGTGCTTCCAGATCATAGTGTTCAG
 161 TGTCCTCTGAAGTAACTGCCTGTTGCCTCTGCTGCCCTTTGAACCAGTGTACAGTCGCCAGATAGGGACCGGTGAACACC
 241 TGATTCCAAACATGTAGGATGGGGGTCTTGTCCTCTTTTTATGTGGTTTAATTGCCAAGTGTCTAAAGCTTAATATGCCG
 321 TGCTATGTAAATATTTTATGGATATAACAACTGTCATATTTTGATGTCAACAGAGTTTTAGGGATAAAATGGTACCCGGC
 401 CAACATCAAGTGACTTTATAGCTGCAAGAAATGTGGTATGTGGAGAAGTTCTGTATGTGAGGAAGGAAAAAAAGAAAATA
 481 AAAGTGTGTTTGAAAAATATTATCTTGGGTTCTTTGTAAAATTTATTTTTTACATGCTGAATTAGCCTCGATCTTTTTGA
 561 TTAAGAGCACAAACTTTTTTTTGTAAAACATGTAAAAAAAAAAACTGGGATTAATTTTTAGTGTTGGAACTGCCTCTTAT
 641 TTTAGGCTGTAGATAAAATAGCATTTTTAGGTTAGCCAGTGTGACTATGCACCTAATTTTTTATGAGATTAAATTCATAA
 721 GACTTAATTTGTACAATAGTTTGTGAAATATCTTGTTACTGCTTTTATTTAGCAGACTGTGGACTGTAATAAAGTATATA
 801 AATTGTGAAATATAAAAACTTGGAACTTATTCAAAGCTTCAAAGCAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' aaCAGGUGAAGAAG--GACGGGAc 5'
            | |:::| | ||  ||||||| 
Target 5' ctGCCTGTTGCCTCTGCTGCCCTt 3'
176 - 199 154.00 -14.20
2
miRNA  3' aacagguGAAGAAGGACGGGAc 5'
                 ||| || ||||::| 
Target 5' gaaatatCTTGTTACTGCTTTt 3'
745 - 766 127.00 -9.00
3
miRNA  3' aacaggugaagaAGGACGGGAc 5'
                      ||:||:||| 
Target 5' gtaggatgggggTCTTGTCCTc 3'
254 - 275 118.00 -10.60
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30146680 5 COSMIC
COSN30165277 5 COSMIC
COSN9758231 10 COSMIC
COSN16127756 11 COSMIC
COSN30102420 13 COSMIC
COSN16131897 18 COSMIC
COSN30102195 102 COSMIC
COSN31543611 181 COSMIC
COSN26573565 186 COSMIC
COSN26643405 193 COSMIC
COSN28820346 232 COSMIC
COSN28670712 266 COSMIC
COSN31549023 336 COSMIC
COSN20099169 605 COSMIC
COSN27517719 605 COSMIC
COSN17388448 765 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1304501463 7 dbSNP
rs1278934946 8 dbSNP
rs763338697 9 dbSNP
rs201624810 12 dbSNP
rs1256210799 13 dbSNP
rs922204724 14 dbSNP
rs1335518461 16 dbSNP
rs1303828802 18 dbSNP
rs1313190748 21 dbSNP
rs932187488 26 dbSNP
rs774888756 29 dbSNP
rs1237871443 33 dbSNP
rs1258648357 39 dbSNP
rs1489073870 43 dbSNP
rs377601541 47 dbSNP
rs763579912 49 dbSNP
rs753397419 51 dbSNP
rs141681330 60 dbSNP
rs888883412 64 dbSNP
rs571294149 73 dbSNP
rs1005932055 74 dbSNP
rs914550559 78 dbSNP
rs1384800812 81 dbSNP
rs150125094 82 dbSNP
rs1482734712 83 dbSNP
rs1016114578 95 dbSNP
rs1041808731 102 dbSNP
rs993453736 108 dbSNP
rs1485118597 117 dbSNP
rs1422303437 123 dbSNP
rs1247112475 125 dbSNP
rs1359751004 137 dbSNP
rs780703576 138 dbSNP
rs576509089 151 dbSNP
rs1296258359 176 dbSNP
rs1390604410 179 dbSNP
rs544374450 182 dbSNP
rs902378414 183 dbSNP
rs1295106179 193 dbSNP
rs1424992072 196 dbSNP
rs1035588859 203 dbSNP
rs960768016 206 dbSNP
rs1451477511 207 dbSNP
rs1373684318 212 dbSNP
rs992581061 217 dbSNP
rs1427277852 218 dbSNP
rs1270045452 226 dbSNP
rs930647011 227 dbSNP
rs1490271751 229 dbSNP
rs562577490 231 dbSNP
rs11844 232 dbSNP
rs1270294845 233 dbSNP
rs1369889426 244 dbSNP
rs542099317 250 dbSNP
rs1226008150 253 dbSNP
rs13577 254 dbSNP
rs925486616 255 dbSNP
rs1304113400 259 dbSNP
rs35283993 260 dbSNP
rs923503112 261 dbSNP
rs1050190 266 dbSNP
rs1397413119 281 dbSNP
rs1167440832 282 dbSNP
rs551931953 287 dbSNP
rs749165525 299 dbSNP
rs1366447859 303 dbSNP
rs1200763345 309 dbSNP
rs1480338424 315 dbSNP
rs572681656 316 dbSNP
rs777780268 316 dbSNP
rs374120794 320 dbSNP
rs541300918 321 dbSNP
rs773985115 326 dbSNP
rs1257882660 327 dbSNP
rs965742493 328 dbSNP
rs1194751881 329 dbSNP
rs1336868769 335 dbSNP
rs1482382968 338 dbSNP
rs149766785 346 dbSNP
rs796951434 346 dbSNP
rs747280272 351 dbSNP
rs1037453562 371 dbSNP
rs1322606783 372 dbSNP
rs1248399990 375 dbSNP
rs976225343 382 dbSNP
rs1281164475 390 dbSNP
rs1444051702 396 dbSNP
rs1336584070 397 dbSNP
rs774027663 398 dbSNP
rs1451036652 399 dbSNP
rs922070169 401 dbSNP
rs564184837 408 dbSNP
rs1469760116 415 dbSNP
rs990805057 423 dbSNP
rs914604360 425 dbSNP
rs1161830808 437 dbSNP
rs960247084 441 dbSNP
rs771225529 447 dbSNP
rs946027386 453 dbSNP
rs11539486 455 dbSNP
rs1804628 464 dbSNP
rs1180644208 467 dbSNP
rs1435615555 470 dbSNP
rs1244418364 475 dbSNP
rs1414995122 480 dbSNP
rs531339546 490 dbSNP
rs1322765294 491 dbSNP
rs1261104257 501 dbSNP
rs1024064297 503 dbSNP
rs1351111445 504 dbSNP
rs1279257846 506 dbSNP
rs745466354 509 dbSNP
rs1356995566 516 dbSNP
rs1237128042 517 dbSNP
rs1465221976 527 dbSNP
rs776879107 535 dbSNP
rs928724781 539 dbSNP
rs1339939647 545 dbSNP
rs575287568 550 dbSNP
rs1451922290 551 dbSNP
rs1404558015 554 dbSNP
rs1320839437 555 dbSNP
rs979523596 557 dbSNP
rs925351395 560 dbSNP
rs956896350 563 dbSNP
rs988279324 570 dbSNP
rs1295887614 571 dbSNP
rs1183669664 575 dbSNP
rs561192497 575 dbSNP
rs564753640 575 dbSNP
rs1217856326 584 dbSNP
rs1447402731 590 dbSNP
rs1283325122 591 dbSNP
rs1361839373 591 dbSNP
rs1220357679 592 dbSNP
rs1361869255 592 dbSNP
rs1303498021 593 dbSNP
rs1315929439 593 dbSNP
rs1245416384 594 dbSNP
rs1272473373 594 dbSNP
rs1432086664 594 dbSNP
rs3834796 594 dbSNP
rs397700218 594 dbSNP
rs938713450 597 dbSNP
rs1056344672 600 dbSNP
rs1426869783 604 dbSNP
rs1367064488 605 dbSNP
rs1050693479 606 dbSNP
rs1443550819 608 dbSNP
rs910251842 610 dbSNP
rs549861117 614 dbSNP
rs894967608 624 dbSNP
rs1475720002 628 dbSNP
rs1037486056 630 dbSNP
rs1213402512 635 dbSNP
rs1490776664 641 dbSNP
rs1292870237 662 dbSNP
rs1206538389 666 dbSNP
rs1241356030 669 dbSNP
rs1478311927 671 dbSNP
rs1275230415 695 dbSNP
rs1215195956 697 dbSNP
rs1361869940 704 dbSNP
rs897592119 721 dbSNP
rs1053970 730 dbSNP
rs1346536055 732 dbSNP
rs1303420283 736 dbSNP
rs139394206 737 dbSNP
rs765221878 747 dbSNP
rs1171913404 757 dbSNP
rs895615923 758 dbSNP
rs537405586 764 dbSNP
rs1013282382 769 dbSNP
rs1481321011 778 dbSNP
rs1269308982 785 dbSNP
rs887672038 792 dbSNP
rs1198365647 797 dbSNP
rs145465828 800 dbSNP
rs1487644612 800 dbSNP
rs774778762 800 dbSNP
rs1205322578 803 dbSNP
rs555141959 805 dbSNP
rs1000805989 809 dbSNP
rs1225855372 815 dbSNP
rs1324777574 819 dbSNP
rs774919522 827 dbSNP
rs1403421570 830 dbSNP
rs965776605 831 dbSNP
rs956792945 835 dbSNP
rs997215200 836 dbSNP
rs1442391137 837 dbSNP
rs1353386898 839 dbSNP
rs1029202295 846 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions Hela
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1048187. RNA binding protein: AGO2. Condition:Hela_AGO2_CLIP_control ...

- Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al., 2013, Cell.

Article - Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al.
- Cell, 2013
The induction of pluripotency or trans-differentiation of one cell type to another can be accomplished with cell-lineage-specific transcription factors. Here, we report that repression of a single RNA binding polypyrimidine-tract-binding (PTB) protein, which occurs during normal brain development via the action of miR-124, is sufficient to induce trans-differentiation of fibroblasts into functional neurons. Besides its traditional role in regulated splicing, we show that PTB has a previously undocumented function in the regulation of microRNA functions, suppressing or enhancing microRNA targeting by competitive binding on target mRNA or altering local RNA secondary structure. A key event during neuronal induction is the relief of PTB-mediated blockage of microRNA action on multiple components of the REST complex, thereby derepressing a large array of neuronal genes, including miR-124 and multiple neuronal-specific transcription factors, in nonneuronal cells. This converts a negative feedback loop to a positive one to elicit cellular reprogramming to the neuronal lineage.
LinkOut: [PMID: 23313552]
CLIP-seq Support 1 for dataset GSM1048187
Method / RBP HITS-CLIP / AGO2
Cell line / Condition Hela / Hela_AGO2_CLIP_control
Location of target site ENST00000539728.1 | 3UTR | UUAUGAGACCACCUUGGAGAAAGGUGUGUGGUACAUGACAUUGGGUUACAUCAUAACGUGCUUCCAGAUCAUAGUGUUCAGUGUCCUCUGAAGUAACUGCCUGUUGCCUCUGCUGCCCUUUGAACCAGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23313552 / GSE42701
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
87 hsa-miR-4436b-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT066957 ATXN7L3B ataxin 7 like 3B 2 8
MIRT119284 NABP1 nucleic acid binding protein 1 2 6
MIRT128915 KMT2A lysine methyltransferase 2A 2 2
MIRT150116 MIDN midnolin 2 2
MIRT173040 YTHDF3 YTH N6-methyladenosine RNA binding protein 3 2 2
MIRT253117 BCL2L12 BCL2 like 12 2 2
MIRT256997 RGMB repulsive guidance molecule family member b 2 2
MIRT259746 SNX12 sorting nexin 12 2 2
MIRT267278 TMEM109 transmembrane protein 109 2 2
MIRT441934 C1orf109 chromosome 1 open reading frame 109 2 2
MIRT443625 CPSF2 cleavage and polyadenylation specific factor 2 2 2
MIRT445757 AGO1 argonaute 1, RISC catalytic component 2 2
MIRT447835 CTIF cap binding complex dependent translation initiation factor 2 2
MIRT451230 ZNF444 zinc finger protein 444 2 2
MIRT451966 TMPRSS5 transmembrane protease, serine 5 2 2
MIRT453127 HOXC4 homeobox C4 2 2
MIRT454604 RPL13A ribosomal protein L13a 2 2
MIRT455176 SUV39H1 suppressor of variegation 3-9 homolog 1 2 2
MIRT455547 GJB1 gap junction protein beta 1 2 2
MIRT458197 ATP6V0A2 ATPase H+ transporting V0 subunit a2 2 2
MIRT458356 NOC2L NOC2 like nucleolar associated transcriptional repressor 2 2
MIRT458923 DNM2 dynamin 2 2 2
MIRT461013 SYT7 synaptotagmin 7 2 2
MIRT461643 ZSWIM4 zinc finger SWIM-type containing 4 2 2
MIRT461997 PACSIN1 protein kinase C and casein kinase substrate in neurons 1 2 2
MIRT462367 BCL7B BCL tumor suppressor 7B 2 2
MIRT464915 TXNIP thioredoxin interacting protein 2 2
MIRT466311 TIMM22 translocase of inner mitochondrial membrane 22 2 2
MIRT466591 TBC1D2B TBC1 domain family member 2B 2 2
MIRT467045 SRSF1 serine and arginine rich splicing factor 1 2 2
MIRT468750 SDC2 syndecan 2 2 2
MIRT468943 RPS24 ribosomal protein S24 2 2
MIRT469474 REEP5 receptor accessory protein 5 2 2
MIRT469913 PTRF caveolae associated protein 1 2 2
MIRT473325 MEX3A mex-3 RNA binding family member A 2 2
MIRT473643 MARK2 microtubule affinity regulating kinase 2 2 2
MIRT474064 LMNB2 lamin B2 2 2
MIRT474357 KMT2D lysine methyltransferase 2D 2 2
MIRT475394 ICMT isoprenylcysteine carboxyl methyltransferase 2 4
MIRT476335 GLTSCR1L BRD4 interacting chromatin remodeling complex associated protein like 2 2
MIRT478651 CTDNEP1 CTD nuclear envelope phosphatase 1 2 2
MIRT479585 CDC42SE1 CDC42 small effector 1 2 2
MIRT479943 CBX5 chromobox 5 2 2
MIRT482001 AMOTL2 angiomotin like 2 2 2
MIRT482043 AMER1 APC membrane recruitment protein 1 2 2
MIRT483070 EXT2 exostosin glycosyltransferase 2 2 6
MIRT484323 KCNH1 potassium voltage-gated channel subfamily H member 1 2 4
MIRT487528 GXYLT2 glucoside xylosyltransferase 2 2 2
MIRT489636 ALS2CL ALS2 C-terminal like 2 2
MIRT490693 SSTR1 somatostatin receptor 1 2 2
MIRT490871 UPK2 uroplakin 2 2 2
MIRT492582 PPM1L protein phosphatase, Mg2+/Mn2+ dependent 1L 2 2
MIRT492945 NEUROD2 neuronal differentiation 2 2 2
MIRT498675 SOD2 superoxide dismutase 2 2 4
MIRT499349 RAB25 RAB25, member RAS oncogene family 2 2
MIRT502338 GIGYF1 GRB10 interacting GYF protein 1 2 4
MIRT502976 CCNL1 cyclin L1 2 8
MIRT503706 NUP62 nucleoporin 62 2 2
MIRT505567 SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1 2 2
MIRT507808 CDKN1B cyclin dependent kinase inhibitor 1B 2 2
MIRT513242 FBXO41 F-box protein 41 2 6
MIRT513586 EVX1 even-skipped homeobox 1 2 2
MIRT525036 FRK fyn related Src family tyrosine kinase 2 2
MIRT531035 TDGF1P3 teratocarcinoma-derived growth factor 1 pseudogene 3 2 2
MIRT531939 RBMS2 RNA binding motif single stranded interacting protein 2 2 2
MIRT534912 PUM2 pumilio RNA binding family member 2 2 2
MIRT535717 N4BP1 NEDD4 binding protein 1 2 2
MIRT540498 ZMAT4 zinc finger matrin-type 4 2 4
MIRT541465 AURKA aurora kinase A 2 2
MIRT554328 SH3GLB1 SH3 domain containing GRB2 like, endophilin B1 2 2
MIRT561572 SLC6A9 solute carrier family 6 member 9 2 2
MIRT564715 ZNF322P1 zinc finger protein 322 pseudogene 1 2 2
MIRT576176 Hmox1 heme oxygenase 1 2 2
MIRT629712 XKR4 XK related 4 2 2
MIRT636182 THBD thrombomodulin 2 2
MIRT646315 MPHOSPH8 M-phase phosphoprotein 8 2 2
MIRT649174 IQSEC1 IQ motif and Sec7 domain 1 2 2
MIRT666945 PMEPA1 prostate transmembrane protein, androgen induced 1 2 2
MIRT684057 FOLR1 folate receptor 1 2 2
MIRT687585 MAU2 MAU2 sister chromatid cohesion factor 2 2
MIRT689953 ZNF185 zinc finger protein 185 with LIM domain 2 2
MIRT704071 SRCAP Snf2 related CREBBP activator protein 2 2
MIRT704327 DCUN1D5 defective in cullin neddylation 1 domain containing 5 2 2
MIRT705406 ATP1B3 ATPase Na+/K+ transporting subunit beta 3 2 2
MIRT710488 CDH5 cadherin 5 2 2
MIRT718241 LCE1A late cornified envelope 1A 2 2
MIRT723182 CDCA4 cell division cycle associated 4 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4436b-3p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-4436b-3p Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR4)

Error report submission