miRTarBase - #MIRT706060


—
pre-miRNA Information
pre-miRNA hsa-mir-6132   
Genomic Coordinates chr7: 117020211 - 117020319
Description Homo sapiens miR-6132 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-6132
Sequence 21| AGCAGGGCUGGGGAUUGCA |39
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1272646274 4 dbSNP
rs1211969145 8 dbSNP
rs1310278496 11 dbSNP
rs1044115534 13 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol PKD1   
Synonyms PBP, PC1, Pc-1, TRPP1
Description polycystin 1, transient receptor potential channel interacting
Transcript NM_000296   
Other Transcripts NM_001009944   
Expression
Putative miRNA Targets on PKD1
3'UTR of PKD1
(miRNA target sites are highlighted)		 
>PKD1|NM_000296|3'UTR
   1 TCCTCCTTCCTGGCGGGGGTGGGCCGTGGAGTCGGAGTGGACACCGCTCAGTATTACTTTCTGCCGCTGTCAAGGCCGAG
  81 GGCCAGGCAGAATGGCTGCACGTAGGTTCCCCAGAGAGCAGGCAGGGGCATCTGTCTGTCTGTGGGCTTCAGCACTTTAA
 161 AGAGGCTGTGTGGCCAACCAGGACCCAGGGTCCCCTCCCCAGCTCCCTTGGGAAGGACACAGCAGTATTGGACGGTTTCT
 241 AGCCTCTGAGATGCTAATTTATTTCCCCGAGTCCTCAGGTACAGCGGGCTGTGCCCGGCCCCACCCCCTGGGCAGATGTC
 321 CCCCACTGCTAAGGCTGCTGGCTTCAGGGAGGGTTAGCCTGCACCGCCGCCACCCTGCCCCTAAGTTATTACCTCTCCAG
 401 TTCCTACCGTACTCCCTGCACCGTCTCACTGTGTGTCTCGTGTCAGTAATTTATATGGTGTTAAAATGTGTATATTTTTG
 481 TATGTCACTATTTTCACTAGGGCTGAGGGGCCTGCGCCCAGAGCTGGCCTCCCCCAACACCTGCTGCGCTTGGTAGGTGT
 561 GGTGGCGTTATGGCAGCCCGGCTGCTGCTTGGATGCGAGCTTGGCCTTGGGCCGGTGCTGGGGGCACAGCTGTCTGCCAG
 641 GCACTCTCATCACCCCAGAGGCCTTGTCATCCTCCCTTGCCCCAGGCCAGGTAGCAAGAGAGCAGCGCCCAGGCCTGCTG
 721 GCATCAGGTCTGGGCAAGTAGCAGGACTAGGCATGTCAGAGGACCCCAGGGTGGTTAGAGGAAAAGACTCCTCCTGGGGG
 801 CTGGCTCCCAGGGTGGAGGAAGGTGACTGTGTGTGTGTGTGTGTGCGCGCGCGCACGCGCGAGTGTGCTGTATGGCCCAG
 881 GCAGCCTCAAGGCCCTCGGAGCTGGCTGTGCCTGCTTCTGTGTACCACTTCTGTGGGCATGGCCGCTTCTAGAGCCTCGA
 961 CACCCCCCCAACCCCCGCACCAAGCAGACAAAGTCAATAAAAGAGCTGTCTGACTGC
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' acGUUAGGGGUCGGGACGa 5'
            ||:  ||||| ||||| 
Target 5' agCAGCGCCCAGGCCTGCt 3'
 701 - 719 133.00 -25.30
2 
miRNA  3' acGUUAGGGGU------CGGGACGa 5'
            ||:|:||:|       |||||| 
Target 5' tcCAGTTCCTACCGTACTCCCTGCa 3'
 396 - 420 123.00 -16.80
3 
miRNA  3' acguuaGGGGU---CGGGACGa 5'
                |||||   |||:||: 
Target 5' tcatcaCCCCAGAGGCCTTGTc 3'
 647 - 668 121.00 -17.00
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
256884 15 ClinVar
1049696 846 ClinVar
1194539 848 ClinVar
1180280 855 ClinVar
1178576 862 ClinVar
64862 970 ClinVar
65179 977 ClinVar
65208 989 ClinVar
65144 990 ClinVar
65276 990 ClinVar
COSN20078604 14 COSMIC
COSN31537968 40 COSMIC
COSN31488061 44 COSMIC
COSN15660759 109 COSMIC
COSN20093050 194 COSMIC
COSN31489930 233 COSMIC
COSN7300909 297 COSMIC
COSN26769728 302 COSMIC
COSN30543727 304 COSMIC
COSN27564835 409 COSMIC
COSN6644781 601 COSMIC
COSN26257692 717 COSMIC
COSN22236664 835 COSMIC
COSN20112544 844 COSMIC
COSN23987363 844 COSMIC
COSN30554789 963 COSMIC
COSN31597361 993 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs779509501 2 dbSNP
rs755569329 3 dbSNP
rs1164276235 5 dbSNP
rs749884546 6 dbSNP
rs767068030 8 dbSNP
rs367762249 9 dbSNP
rs764028522 10 dbSNP
rs373918732 14 dbSNP
rs77566834 15 dbSNP
rs113679594 17 dbSNP
rs1452487267 19 dbSNP
rs1195749154 20 dbSNP
rs1452940660 23 dbSNP
rs759478253 24 dbSNP
rs776638372 25 dbSNP
rs1374846916 26 dbSNP
rs1384723785 26 dbSNP
rs771102722 28 dbSNP
rs566279575 29 dbSNP
rs112780826 33 dbSNP
rs530758271 34 dbSNP
rs1275189794 35 dbSNP
rs1438408130 36 dbSNP
rs562017501 37 dbSNP
rs1435325131 38 dbSNP
rs1325564344 39 dbSNP
rs1436097985 41 dbSNP
rs368143590 42 dbSNP
rs755484175 44 dbSNP
rs541715653 45 dbSNP
rs375155193 46 dbSNP
rs926703768 47 dbSNP
rs1464656598 48 dbSNP
rs559096849 49 dbSNP
rs1477276969 50 dbSNP
rs1440702204 53 dbSNP
rs1186765144 56 dbSNP
rs982607400 57 dbSNP
rs540358072 60 dbSNP
rs997006362 61 dbSNP
rs901377656 63 dbSNP
rs577702794 64 dbSNP
rs557909051 65 dbSNP
rs372311716 66 dbSNP
rs1290262392 67 dbSNP
rs538237594 68 dbSNP
rs1399454620 69 dbSNP
rs908803184 71 dbSNP
rs1341634726 75 dbSNP
rs972083553 76 dbSNP
rs575504362 77 dbSNP
rs556035783 78 dbSNP
rs1229253042 82 dbSNP
rs535740062 84 dbSNP
rs1482328984 87 dbSNP
rs1199898398 90 dbSNP
rs1236128331 91 dbSNP
rs777483574 98 dbSNP
rs926356423 99 dbSNP
rs980518122 100 dbSNP
rs953677462 101 dbSNP
rs949213110 102 dbSNP
rs917781648 106 dbSNP
rs987992910 109 dbSNP
rs998332804 110 dbSNP
rs956796992 111 dbSNP
rs185343851 112 dbSNP
rs773278017 113 dbSNP
rs1032270911 114 dbSNP
rs1042428027 114 dbSNP
rs2855368 115 dbSNP
rs1299583763 118 dbSNP
rs1412419653 119 dbSNP
rs754881835 121 dbSNP
rs1009215377 122 dbSNP
rs978742004 123 dbSNP
rs547199668 124 dbSNP
rs968737633 126 dbSNP
rs1310703688 127 dbSNP
rs1028404925 128 dbSNP
rs996975085 129 dbSNP
rs1256725407 130 dbSNP
rs1350137871 131 dbSNP
rs1053648230 132 dbSNP
rs937806465 132 dbSNP
rs1178770447 134 dbSNP
rs1483279385 134 dbSNP
rs901261694 137 dbSNP
rs1020167534 138 dbSNP
rs1199130729 139 dbSNP
rs772300257 140 dbSNP
rs1046265575 143 dbSNP
rs777664625 144 dbSNP
rs919377188 145 dbSNP
rs887335186 147 dbSNP
rs1048664501 151 dbSNP
rs963389051 152 dbSNP
rs930966731 159 dbSNP
rs1304355286 160 dbSNP
rs909422258 160 dbSNP
rs904900456 161 dbSNP
rs1044788614 162 dbSNP
rs113262713 164 dbSNP
rs917681089 166 dbSNP
rs1186012029 168 dbSNP
rs748485709 168 dbSNP
rs1273971562 172 dbSNP
rs1308058698 173 dbSNP
rs988349329 174 dbSNP
rs1263532381 178 dbSNP
rs1487998834 179 dbSNP
rs1210080735 180 dbSNP
rs1254435440 183 dbSNP
rs997720002 184 dbSNP
rs1256997317 189 dbSNP
rs935194889 190 dbSNP
rs878903703 192 dbSNP
rs539581650 193 dbSNP
rs1457668261 198 dbSNP
rs1326867294 200 dbSNP
rs1397012843 203 dbSNP
rs774721414 205 dbSNP
rs1219643535 207 dbSNP
rs1320401594 210 dbSNP
rs1020674438 216 dbSNP
rs570557165 220 dbSNP
rs550355361 221 dbSNP
rs1320918487 227 dbSNP
rs530534662 228 dbSNP
rs867756350 230 dbSNP
rs1463303300 231 dbSNP
rs1339480270 233 dbSNP
rs561489343 234 dbSNP
rs1053597274 236 dbSNP
rs1412197969 239 dbSNP
rs769291648 243 dbSNP
rs139573366 244 dbSNP
rs905132047 250 dbSNP
rs1330544126 253 dbSNP
rs1320066659 256 dbSNP
rs1046644604 258 dbSNP
rs949259809 260 dbSNP
rs1425565939 264 dbSNP
rs1162488321 265 dbSNP
rs766153620 265 dbSNP
rs919309114 265 dbSNP
rs528351015 266 dbSNP
rs1472632292 267 dbSNP
rs1004771537 268 dbSNP
rs752472135 269 dbSNP
rs941974355 269 dbSNP
rs779759485 271 dbSNP
rs909207729 273 dbSNP
rs1436089216 276 dbSNP
rs1207464260 278 dbSNP
rs995753401 278 dbSNP
rs559158862 283 dbSNP
rs1485665373 284 dbSNP
rs545586456 285 dbSNP
rs1044675322 286 dbSNP
rs949067437 287 dbSNP
rs1158739459 295 dbSNP
rs1271709209 295 dbSNP
rs896198372 296 dbSNP
rs181814805 297 dbSNP
rs935155314 298 dbSNP
rs1284354761 299 dbSNP
rs1246387958 302 dbSNP
rs1314572263 303 dbSNP
rs755653968 304 dbSNP
rs1408939851 305 dbSNP
rs1333424347 306 dbSNP
rs925181097 308 dbSNP
rs1277385607 311 dbSNP
rs745341634 318 dbSNP
rs564609458 328 dbSNP
rs544340999 329 dbSNP
rs1283034920 330 dbSNP
rs1020622120 337 dbSNP
rs987859249 338 dbSNP
rs921861004 341 dbSNP
rs957822502 348 dbSNP
rs975387518 349 dbSNP
rs575611619 350 dbSNP
rs555453899 351 dbSNP
rs1001905592 352 dbSNP
rs1435354719 353 dbSNP
rs752234831 354 dbSNP
rs1368587863 359 dbSNP
rs912624205 362 dbSNP
rs982921818 364 dbSNP
rs73498118 365 dbSNP
rs756873400 366 dbSNP
rs751313275 368 dbSNP
rs1013795627 369 dbSNP
rs573566934 369 dbSNP
rs187331220 370 dbSNP
rs1274228192 373 dbSNP
rs1036227896 378 dbSNP
rs1442160215 379 dbSNP
rs1252554414 380 dbSNP
rs942093738 385 dbSNP
rs1195619933 389 dbSNP
rs1251612403 391 dbSNP
rs1388388206 391 dbSNP
rs887887822 392 dbSNP
rs1050406101 393 dbSNP
rs1221299997 395 dbSNP
rs540040398 398 dbSNP
rs923495188 399 dbSNP
rs1322515397 402 dbSNP
rs1394818339 404 dbSNP
rs1290175680 405 dbSNP
rs181780746 408 dbSNP
rs758383845 409 dbSNP
rs946172953 410 dbSNP
rs1052613746 412 dbSNP
rs999245923 414 dbSNP
rs903614823 415 dbSNP
rs990301126 416 dbSNP
rs957770047 417 dbSNP
rs1043550238 419 dbSNP
rs752613073 420 dbSNP
rs766489027 421 dbSNP
rs921828318 422 dbSNP
rs190152551 423 dbSNP
rs1374687403 425 dbSNP
rs545371620 427 dbSNP
rs1025276182 428 dbSNP
rs1331423414 428 dbSNP
rs568078250 429 dbSNP
rs944028454 430 dbSNP
rs1013493799 431 dbSNP
rs897787085 431 dbSNP
rs1383632228 433 dbSNP
rs1382248077 437 dbSNP
rs367951136 437 dbSNP
rs762793687 437 dbSNP
rs912603398 437 dbSNP
rs373639226 439 dbSNP
rs547863566 440 dbSNP
rs1266421244 442 dbSNP
rs920022480 445 dbSNP
rs887834107 446 dbSNP
rs1205840255 449 dbSNP
rs974186957 449 dbSNP
rs1440683686 455 dbSNP
rs1187127746 456 dbSNP
rs1257967786 458 dbSNP
rs969550464 461 dbSNP
rs1156532485 462 dbSNP
rs1023827234 467 dbSNP
rs1159339894 470 dbSNP
rs1421519298 472 dbSNP
rs1013879243 474 dbSNP
rs528412312 476 dbSNP
rs1312745441 478 dbSNP
rs1030634516 483 dbSNP
rs1356530770 485 dbSNP
rs999612084 486 dbSNP
rs1335453578 488 dbSNP
rs1478628296 488 dbSNP
rs1262632179 491 dbSNP
rs1342874893 492 dbSNP
rs1210090435 493 dbSNP
rs773297182 497 dbSNP
rs1179796466 499 dbSNP
rs1249530471 500 dbSNP
rs556570291 502 dbSNP
rs1191477301 503 dbSNP
rs946283973 509 dbSNP
rs1487136580 510 dbSNP
rs1375443119 512 dbSNP
rs565636902 514 dbSNP
rs183979118 515 dbSNP
rs1043518994 516 dbSNP
rs1355180878 518 dbSNP
rs1437103279 519 dbSNP
rs1276450855 521 dbSNP
rs1396214248 521 dbSNP
rs1218626538 524 dbSNP
rs1345592862 527 dbSNP
rs936190439 533 dbSNP
rs1233605223 534 dbSNP
rs1350023749 535 dbSNP
rs924992457 537 dbSNP
rs1250555041 540 dbSNP
rs980553044 541 dbSNP
rs1264780194 542 dbSNP
rs1397901251 542 dbSNP
rs2854588 543 dbSNP
rs995998310 544 dbSNP
rs772899303 546 dbSNP
rs1040691772 547 dbSNP
rs944599331 548 dbSNP
rs1168866134 549 dbSNP
rs1372878470 551 dbSNP
rs1357548708 552 dbSNP
rs1175405885 553 dbSNP
rs961944453 563 dbSNP
rs1300143432 564 dbSNP
rs762029876 565 dbSNP
rs764840200 566 dbSNP
rs774922931 566 dbSNP
rs769130086 567 dbSNP
rs532185158 568 dbSNP
rs749851663 569 dbSNP
rs1212750775 570 dbSNP
rs974154277 571 dbSNP
rs1271018020 572 dbSNP
rs901964044 577 dbSNP
rs563305714 579 dbSNP
rs776172110 580 dbSNP
rs1463113897 581 dbSNP
rs1185305742 586 dbSNP
rs544713931 587 dbSNP
rs1261589936 590 dbSNP
rs1429595075 593 dbSNP
rs1235286089 596 dbSNP
rs892023610 597 dbSNP
rs3087631 601 dbSNP
rs936136687 603 dbSNP
rs992746427 604 dbSNP
rs1288334335 605 dbSNP
rs1280562010 607 dbSNP
rs1383841911 609 dbSNP
rs960961194 613 dbSNP
rs371496391 614 dbSNP
rs1233535642 616 dbSNP
rs977769185 619 dbSNP
rs1274605142 621 dbSNP
rs776141886 622 dbSNP
rs1314645231 624 dbSNP
rs1214502012 626 dbSNP
rs1216604235 627 dbSNP
rs1317019506 631 dbSNP
rs927473939 633 dbSNP
rs1044995706 634 dbSNP
rs1420343599 636 dbSNP
rs947813833 636 dbSNP
rs1158546067 637 dbSNP
rs577209727 637 dbSNP
rs542240060 638 dbSNP
rs1345853942 640 dbSNP
rs573226497 642 dbSNP
rs917690037 643 dbSNP
rs780683017 644 dbSNP
rs967735315 645 dbSNP
rs1294871627 646 dbSNP
rs1022045835 649 dbSNP
rs984714341 649 dbSNP
rs1222839520 651 dbSNP
rs1284427532 653 dbSNP
rs995965746 654 dbSNP
rs900255572 656 dbSNP
rs1278764122 657 dbSNP
rs1485612752 657 dbSNP
rs951976370 658 dbSNP
rs768097806 661 dbSNP
rs1018745193 666 dbSNP
rs1028824293 669 dbSNP
rs1465457113 670 dbSNP
rs996440305 672 dbSNP
rs1424855757 676 dbSNP
rs3743870 678 dbSNP
rs1009159039 679 dbSNP
rs1314557101 680 dbSNP
rs1352541452 681 dbSNP
rs886332968 682 dbSNP
rs1173234001 683 dbSNP
rs1279712589 685 dbSNP
rs966125943 685 dbSNP
rs756923313 686 dbSNP
rs553711172 687 dbSNP
rs1010152405 688 dbSNP
rs1235658417 690 dbSNP
rs891803760 691 dbSNP
rs1204114312 695 dbSNP
rs111786159 696 dbSNP
rs1459236575 698 dbSNP
rs1191885624 700 dbSNP
rs774921866 701 dbSNP
rs1394547035 702 dbSNP
rs1454709740 703 dbSNP
rs368013485 706 dbSNP
rs746657260 707 dbSNP
rs1329261652 711 dbSNP
rs1038339239 714 dbSNP
rs1438241694 715 dbSNP
rs1324709579 716 dbSNP
rs1371003477 717 dbSNP
rs777597080 718 dbSNP
rs1337895323 719 dbSNP
rs1214394495 721 dbSNP
rs916666157 722 dbSNP
rs1320348921 723 dbSNP
rs1212054987 724 dbSNP
rs1180789393 725 dbSNP
rs1472816591 726 dbSNP
rs1200942487 729 dbSNP
rs867318438 732 dbSNP
rs1044559724 735 dbSNP
rs577387279 738 dbSNP
rs191697830 739 dbSNP
rs896214489 742 dbSNP
rs1163685077 744 dbSNP
rs1394606039 745 dbSNP
rs771261310 747 dbSNP
rs978783873 750 dbSNP
rs1258541403 751 dbSNP
rs868402230 751 dbSNP
rs1325255215 753 dbSNP
rs967702702 755 dbSNP
rs1021929742 758 dbSNP
rs1320154059 758 dbSNP
rs1312193120 761 dbSNP
rs1056230385 767 dbSNP
rs974412944 769 dbSNP
rs1231701088 770 dbSNP
rs1228996345 771 dbSNP
rs758162646 773 dbSNP
rs1381368270 774 dbSNP
rs537187222 776 dbSNP
rs1474073094 778 dbSNP
rs907531409 778 dbSNP
rs984495309 781 dbSNP
rs572959816 786 dbSNP
rs568867686 788 dbSNP
rs568056589 789 dbSNP
rs577103612 790 dbSNP
rs1342799987 793 dbSNP
rs1405567448 796 dbSNP
rs1293039413 801 dbSNP
rs1356403314 805 dbSNP
rs565298575 810 dbSNP
rs187992537 812 dbSNP
rs1277857563 813 dbSNP
rs1176232736 815 dbSNP
rs1349970515 818 dbSNP
rs1205666020 819 dbSNP
rs886297772 822 dbSNP
rs778239438 823 dbSNP
rs1209959991 824 dbSNP
rs988846621 825 dbSNP
rs956161943 827 dbSNP
rs994676166 829 dbSNP
rs1470156124 830 dbSNP
rs201512489 831 dbSNP
rs532247261 831 dbSNP
rs569861397 834 dbSNP
rs867763743 835 dbSNP
rs1222652018 836 dbSNP
rs754602023 836 dbSNP
rs772394688 836 dbSNP
rs1312722574 837 dbSNP
rs1012223154 838 dbSNP
rs386787811 838 dbSNP
rs762211174 838 dbSNP
rs1323698822 839 dbSNP
rs200372958 840 dbSNP
rs895213866 840 dbSNP
rs1311531741 841 dbSNP
rs549700419 842 dbSNP
rs74002777 844 dbSNP
rs368632657 845 dbSNP
rs142285430 846 dbSNP
rs1484079471 846 dbSNP
rs2855370 846 dbSNP
rs374706125 846 dbSNP
rs56279647 846 dbSNP
rs71827510 846 dbSNP
rs79778984 846 dbSNP
rs562044040 847 dbSNP
rs1294591241 848 dbSNP
rs1371941622 848 dbSNP
rs895981838 848 dbSNP
rs946916774 848 dbSNP
rs915509688 849 dbSNP
rs1196159945 850 dbSNP
rs1469733350 850 dbSNP
rs1478326984 850 dbSNP
rs542301182 850 dbSNP
rs528508419 851 dbSNP
rs796836475 851 dbSNP
rs1354487874 852 dbSNP
rs1401656003 852 dbSNP
rs559752557 852 dbSNP
rs940419176 852 dbSNP
rs1314556243 853 dbSNP
rs987659018 853 dbSNP
rs1214307779 854 dbSNP
rs1385472347 854 dbSNP
rs1491271779 854 dbSNP
rs1048729638 855 dbSNP
rs1219312904 855 dbSNP
rs561630495 855 dbSNP
rs879324018 855 dbSNP
rs886213856 855 dbSNP
rs950575369 855 dbSNP
rs1026534165 856 dbSNP
rs1304175748 857 dbSNP
rs1448323908 857 dbSNP
rs570784945 857 dbSNP
rs930324355 858 dbSNP
rs1222749825 859 dbSNP
rs13332377 859 dbSNP
rs111648142 860 dbSNP
rs1278648780 861 dbSNP
rs78282474 861 dbSNP
rs944671596 861 dbSNP
rs1178168657 862 dbSNP
rs1441475300 862 dbSNP
rs1479765725 862 dbSNP
rs1367036961 863 dbSNP
rs1156318445 864 dbSNP
rs1394279685 865 dbSNP
rs1177932432 866 dbSNP
rs1418488339 866 dbSNP
rs1022861481 867 dbSNP
rs1352451539 867 dbSNP
rs1012190291 868 dbSNP
rs928885380 868 dbSNP
rs748318720 869 dbSNP
rs374108045 870 dbSNP
rs895173653 872 dbSNP
rs1056551211 874 dbSNP
rs978764456 876 dbSNP
rs1003996646 878 dbSNP
rs567025319 880 dbSNP
rs1431347885 882 dbSNP
rs1459109429 884 dbSNP
rs1191706545 885 dbSNP
rs1266459512 886 dbSNP
rs902604389 887 dbSNP
rs567880403 888 dbSNP
rs1192763886 893 dbSNP
rs1042551574 894 dbSNP
rs946885769 895 dbSNP
rs563951265 897 dbSNP
rs183689703 898 dbSNP
rs1324604492 899 dbSNP
rs35441076 900 dbSNP
rs763430709 900 dbSNP
rs1039330269 905 dbSNP
rs943040781 906 dbSNP
rs911585648 908 dbSNP
rs987163812 910 dbSNP
rs371125343 912 dbSNP
rs950491593 914 dbSNP
rs919027909 915 dbSNP
rs973194701 917 dbSNP
rs34182480 918 dbSNP
rs1347011333 920 dbSNP
rs1452176020 924 dbSNP
rs368452156 924 dbSNP
rs1240163904 927 dbSNP
rs1477348800 927 dbSNP
rs1194078522 928 dbSNP
rs1398874197 928 dbSNP
rs1474012227 929 dbSNP
rs1162196107 930 dbSNP
rs775937434 931 dbSNP
rs960359165 932 dbSNP
rs1022828927 936 dbSNP
rs1326057934 938 dbSNP
rs1464541497 938 dbSNP
rs1012826356 939 dbSNP
rs1376991469 940 dbSNP
rs554253529 941 dbSNP
rs1004414028 943 dbSNP
rs554255347 944 dbSNP
rs776059099 945 dbSNP
rs1282113142 948 dbSNP
rs1217137451 950 dbSNP
rs994478294 950 dbSNP
rs1265049997 954 dbSNP
rs534381681 958 dbSNP
rs1003558653 959 dbSNP
rs1368565623 961 dbSNP
rs1038735192 963 dbSNP
rs571731180 964 dbSNP
rs902572213 966 dbSNP
rs1299264024 968 dbSNP
rs1362775126 969 dbSNP
rs1333704645 970 dbSNP
rs1394525190 970 dbSNP
rs397514891 970 dbSNP
rs781421943 972 dbSNP
rs1341260303 973 dbSNP
rs558109446 974 dbSNP
rs538964708 976 dbSNP
rs1052857037 977 dbSNP
rs1240696715 977 dbSNP
rs202247051 977 dbSNP
rs894010540 977 dbSNP
rs926002084 978 dbSNP
rs1345407745 979 dbSNP
rs1199556630 982 dbSNP
rs979264685 983 dbSNP
rs1198786097 984 dbSNP
rs1179126511 985 dbSNP
rs970202456 986 dbSNP
rs1483216769 987 dbSNP
rs730882074 989 dbSNP
rs34379884 990 dbSNP
rs1464890960 991 dbSNP
rs960266423 991 dbSNP
rs992866439 991 dbSNP
rs1172335318 992 dbSNP
rs943576288 992 dbSNP
rs1397997360 993 dbSNP
rs150008139 993 dbSNP
rs1376177111 994 dbSNP
rs1311319790 997 dbSNP
rs1447448818 997 dbSNP
rs1345608098 1002 dbSNP
rs34246147 1003 dbSNP
rs1316393843 1004 dbSNP
rs1004345164 1006 dbSNP
rs1346768812 1011 dbSNP
rs1256886891 1013 dbSNP
rs890728712 1013 dbSNP
rs952864367 1013 dbSNP
rs550001058 1014 dbSNP
rs1051844894 1015 dbSNP
rs536065645 1016 dbSNP
rs1319785726 1017 dbSNP
rs918995030 1018 dbSNP
rs567432587 1019 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions BC-3
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1015449. RNA binding protein: AGO2. Condition:BC-3 mRNA ...

- Haecker I; Gay LA; Yang Y; Hu J; Morse AM; et al., 2012, PLoS pathogens.

Article - Haecker I; Gay LA; Yang Y; Hu J; Morse AM; et al.
- PLoS pathogens, 2012
KSHV is the etiological agent of Kaposi's sarcoma (KS), primary effusion lymphoma (PEL), and a subset of multicentricCastleman's disease (MCD). The fact that KSHV-encoded miRNAs are readily detectable in all KSHV-associated tumors suggests a potential role in viral pathogenesis and tumorigenesis. MiRNA-mediated regulation of gene expression is a complex network with each miRNA having many potential targets, and to date only few KSHV miRNA targets have been experimentally determined. A detailed understanding of KSHV miRNA functions requires high-through putribonomics to globally analyze putative miRNA targets in a cell type-specific manner. We performed Ago HITS-CLIP to identify viral and cellular miRNAs and their cognate targets in two latently KSHV-infected PEL cell lines. Ago HITS-CLIP recovered 1170 and 950 cellular KSHV miRNA targets from BCBL-1 and BC-3, respectively. Importantly, enriched clusters contained KSHV miRNA seed matches in the 3'UTRs of numerous well characterized targets, among them THBS1, BACH1, and C/EBPbeta. KSHV miRNA targets were strongly enriched for genes involved in multiple pathways central for KSHV biology, such as apoptosis, cell cycle regulation, lymphocyte proliferation, and immune evasion, thus further supporting a role in KSHV pathogenesis and potentially tumorigenesis. A limited number of viral transcripts were also enriched by HITS-CLIP including vIL-6 expressed only in a subset of PEL cells during latency. Interestingly, Ago HITS-CLIP revealed extremely high levels of Ago-associated KSHV miRNAs especially in BC-3 cells where more than 70% of all miRNAs are of viral origin. This suggests that in addition to seed match-specific targeting of cellular genes, KSHV miRNAs may also function by hijacking RISCs, thereby contributing to a global de-repression of cellular gene expression due to the loss of regulation by human miRNAs. In summary, we provide an extensive list of cellular and viral miRNA targets representing an important resource to decipher KSHV miRNA function.
LinkOut: [PMID: 22927820]
CLIP-seq Support 1 for dataset GSM1015449
Method / RBP HITS-CLIP / AGO2
Cell line / Condition BC-3 / BC-3 mRNA
Location of target site ENST00000262304.4 | 3UTR | ACCCUGCCCCUAAGUUAUUACCUCUCCAGUUCCUACCGUACUCCCUGCACCGUCUCACUGUGUGUCUCGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 22927820 / GSE41357
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
82 hsa-miR-6132 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT067294 NECAP1 NECAP endocytosis associated 1 2 10
MIRT100110 ABT1 activator of basal transcription 1 2 8
MIRT358583 CANX calnexin 2 2
MIRT445247 SEMA5A semaphorin 5A 2 2
MIRT445764 CCND3 cyclin D3 2 2
MIRT452388 LY6E lymphocyte antigen 6 family member E 2 4
MIRT452829 FAM131B family with sequence similarity 131 member B 2 2
MIRT453450 GLG1 golgi glycoprotein 1 2 2
MIRT455435 ID3 inhibitor of DNA binding 3, HLH protein 2 2
MIRT460629 IGFBP4 insulin like growth factor binding protein 4 2 2
MIRT461607 DPH2 DPH2 homolog 2 2
MIRT461989 PACSIN1 protein kinase C and casein kinase substrate in neurons 1 2 2
MIRT464258 VCL vinculin 2 2
MIRT465713 TNFAIP1 TNF alpha induced protein 1 2 2
MIRT466475 TECPR2 tectonin beta-propeller repeat containing 2 2 7
MIRT467119 SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 2 4
MIRT468299 SFT2D2 SFT2 domain containing 2 2 2
MIRT469696 RAB5B RAB5B, member RAS oncogene family 2 8
MIRT469904 PTRF caveolae associated protein 1 2 2
MIRT470015 PTPLB 3-hydroxyacyl-CoA dehydratase 2 1 1
MIRT471385 PDPR pyruvate dehydrogenase phosphatase regulatory subunit 2 2
MIRT471409 PDP2 pyruvate dehyrogenase phosphatase catalytic subunit 2 2 2
MIRT471719 OTUB1 OTU deubiquitinase, ubiquitin aldehyde binding 1 2 2
MIRT473608 MARK2 microtubule affinity regulating kinase 2 2 2
MIRT476328 GLTSCR1L BRD4 interacting chromatin remodeling complex associated protein like 2 2
MIRT479448 CDK6 cyclin dependent kinase 6 2 2
MIRT482032 AMER1 APC membrane recruitment protein 1 2 2
MIRT482360 AGO2 argonaute 2, RISC catalytic component 2 2
MIRT484661 HOXD3 homeobox D3 2 4
MIRT486828 NDOR1 NADPH dependent diflavin oxidoreductase 1 2 2
MIRT487069 CLASP1 cytoplasmic linker associated protein 1 2 4
MIRT487196 NFASC neurofascin 2 4
MIRT487448 TFAP2B transcription factor AP-2 beta 2 4
MIRT487517 GXYLT2 glucoside xylosyltransferase 2 2 2
MIRT487640 BRSK2 BR serine/threonine kinase 2 2 4
MIRT487755 SKI SKI proto-oncogene 2 4
MIRT489944 CPLX1 complexin 1 2 2
MIRT491101 MSI1 musashi RNA binding protein 1 2 4
MIRT491181 LAMA5 laminin subunit alpha 5 2 2
MIRT492355 SEMA7A semaphorin 7A (John Milton Hagen blood group) 2 2
MIRT493918 FAM127B retrotransposon Gag like 8A 2 4
MIRT493932 FAM127A retrotransposon Gag like 8C 2 4
MIRT494679 ARID3A AT-rich interaction domain 3A 2 2
MIRT494814 AKAP11 A-kinase anchoring protein 11 2 2
MIRT494835 ADCY9 adenylate cyclase 9 2 2
MIRT495455 PNMAL2 paraneoplastic Ma antigen family member 8B 2 2
MIRT496962 MAP1LC3B microtubule associated protein 1 light chain 3 beta 2 2
MIRT526228 MTRNR2L5 MT-RNR2-like 5 2 2
MIRT531028 TDGF1P3 teratocarcinoma-derived growth factor 1 pseudogene 3 2 2
MIRT557110 HOXA3 homeobox A3 2 2
MIRT560514 POGK pogo transposable element derived with KRAB domain 2 2
MIRT567753 DLC1 DLC1 Rho GTPase activating protein 2 2
MIRT569608 TRIM29 tripartite motif containing 29 2 2
MIRT570242 CPNE5 copine 5 2 2
MIRT572327 HSPB6 heat shock protein family B (small) member 6 2 2
MIRT572373 ATOX1 antioxidant 1 copper chaperone 2 2
MIRT575024 Tecpr2 tectonin beta-propeller repeat containing 2 2 5
MIRT576146 Hmox1 heme oxygenase 1 2 2
MIRT612443 SMOC2 SPARC related modular calcium binding 2 2 2
MIRT615404 VDAC2 voltage dependent anion channel 2 2 2
MIRT629114 CYCS cytochrome c, somatic 2 2
MIRT631362 FOXI2 forkhead box I2 2 2
MIRT639322 THBD thrombomodulin 2 2
MIRT643797 ABCC12 ATP binding cassette subfamily C member 12 2 2
MIRT669687 ABLIM1 actin binding LIM protein 1 2 2
MIRT670595 LLGL1 LLGL1, scribble cell polarity complex component 2 4
MIRT691190 NIF3L1 NGG1 interacting factor 3 like 1 2 2
MIRT691688 FLOT2 flotillin 2 2 2
MIRT697127 OTUD5 OTU deubiquitinase 5 2 2
MIRT700814 PHLDA2 pleckstrin homology like domain family A member 2 2 2
MIRT701248 NUP35 nucleoporin 35 2 2
MIRT702362 KLHL15 kelch like family member 15 2 2
MIRT703325 GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 2 2
MIRT706060 PKD1 polycystin 1, transient receptor potential channel interacting 2 2
MIRT710475 CDH5 cadherin 5 2 2
MIRT713018 SLC4A2 solute carrier family 4 member 2 2 2
MIRT716427 RAB15 RAB15, member RAS oncogene family 2 2
MIRT718093 ABHD12 abhydrolase domain containing 12 2 2
MIRT718542 PIGQ phosphatidylinositol glycan anchor biosynthesis class Q 2 2
MIRT719122 CACFD1 calcium channel flower domain containing 1 2 2
MIRT721393 LDLRAD4 low density lipoprotein receptor class A domain containing 4 2 2
MIRT736283 CDC42 cell division cycle 42 2 0
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-6132 Vemurafenib 42611257 NSC761431 approved resistant High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-6132 Dabrafenib 44462760 NSC764134 approved resistant High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-6132 Paclitaxel 36314 NSC125973 approved resistant High Non-Small Cell Lung Cancer cell line (A549)
hsa-miR-6132 Cisplatin 5460033 NSC119875 approved resistant High Hypopharyngeal Cancer cell line (FaDu)
hsa-miR-6132 Temozolomide 5394 NSC362856 approved sensitive cell line (U251)
hsa-miR-6132 Cisplatin 5460033 NSC119875 approved sensitive cell line
hsa-miR-6132 Doxorubicin 31703 NSC123127 approved resistant cell line (HS578T)
hsa-miR-6132 Osimertinib 71496458 NSC779217 approved resistant cell line (H1975)
hsa-miR-6132 Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (100 ng/ml)

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