pre-miRNA Information
pre-miRNA hsa-mir-6751   
Genomic Coordinates chr11: 65129916 - 65129978
Description Homo sapiens miR-6751 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-6751-3p
Sequence 43| ACUGAGCCUCUCUCUCUCCAG |63
Evidence Experimental
Experiments Meta-analysis
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSM6795708 8 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs749989972 2 dbSNP
rs1266150108 3 dbSNP
rs1488089412 6 dbSNP
rs1259846893 8 dbSNP
rs3802937 10 dbSNP
rs371083440 12 dbSNP
rs1264909843 13 dbSNP
rs751042478 14 dbSNP
rs757551063 19 dbSNP
Putative Targets

Gene Information
Gene Symbol RAI1   
Synonyms SMCR, SMS
Description retinoic acid induced 1
Transcript NM_030665   
Expression
Putative miRNA Targets on RAI1
3'UTR of RAI1
(miRNA target sites are highlighted)
>RAI1|NM_030665|3'UTR
   1 TAATCCACCCCAACGGCCGGAGGAGCCGCCGGAGCCCGCCTGCCCGCCCGCCGCCGAAGGAGAGGAGCCGCCTGCGCAGC
  81 CCCCGGGCCTTTGAGCTGCTCCCAGCGCTGGTCCAGAGCCGATCCTTGATCCGGGTCCCGGATCGTGGATCCGGCCGCCT
 161 AGGGCTCAGACTTGCGGCCCCGGGTTGGGAGGAAAACCCGTTCCGGAGCCGCCTGCTCCCGGAACCGGACGGCACAGGGC
 241 GTTCTTGCCCACCCCAGGGGCCAGGCTTGCGGAGGGGGAGCCCGCGGAGCGGCCAGACTCCCCGGGGCGCTCAGCCTCCG
 321 GCGAGGGTGGGAGACGGCTTTGTCCTGGGGACACTTTCCCTCTGGAATCTCAAGACGACGTGGCACACATTCCACGTGGG
 401 TGCTGCCGCCACCCCAGTCGGTCGTGGCGTGCAGCTGGGAGCCCTGGGCTTGGGGGTGGGGGTCGAAACAGTACTGGAAG
 481 AGGCGGAGGGCGGCTCCTAGCTCCGTGGACTAGGCGGGGGAGAAAGGAAGCCTTTCTGAGAGCGGGCTAGGCCGGCACTG
 561 GAGAGGCCGGAGCCTTTGGAACAAACCGTGCGGAACGCGTCCAGGGGCCTTCCCGCCCAGCCTTTGCCAGATCTCTCGTG
 641 CGGTTCGGGCAAAGCCGGGGTAGACCTGGGCTATGCTCAGTTAGGGGTTGCGGGATCCCCGAGTGTGGGCGGGACTGGGA
 721 CACCCTTTGGCCTCTGTTTGTCCCCTTTCCAGTCCTCCACCCCACCCCTGGAGCCCAGCCTGGGAGCGCAAAACCCAAGA
 801 AGCGGCCAGAACGCACCTCCGGCTCCGGCGGACGCGCGACCGTTGTGCACCACCAGGGACCGCCGCGCCTACTCTGCACG
 881 GGAGCAGGGACAGCGCTAGATTTCGTGTACAAAACCTGTGTACCCCTCTATATATATGTTACATAGAATGTATATATGTT
 961 GGGAACATGCTCGCTTCTCCCGTGTGTCGCCGCCGTGCGTCGTGCGCCCGCAACAGAGCCCCAACCGGGCCTTTGCCGGG
1041 TAAGGGGCTACCGCGACGCCACTTGTCCACGCAGCCACCACCGGCCCGGGCCAGTCCCTGCCAGTCCGTCCGCCTGTCCG
1121 TCCGTGTCCTCAGCTCTGTCCACGCTTCGATAGGCCTGACGCAGCCCCCAGCCCAGGGCCGCCCTAGCAACTTCCTGTAC
1201 ATATGACTGTAAAATGGTAAACGTGTGTATTATATCTGGCCTCGTTATATAGTGTATATATATGTATACATATACATATA
1281 TATAATATATATGAAGACTGTAAATGTTAAGACGACTAGTGTTCTTATTAGTATATTGCTTCACACTGAAGATTGTGTGT
1361 ATCGAGCTGTTTCTAAAAGATGTTTATTTTCCTTAAGAGTAAAAAACAGTCATTGCATTCAGAAAAAAAAAAAAAAAAAA
1441 GTCAATAAAGATACAACGATTGTTTTGGAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' gaccucucucUCUCCGAGUCa 5'
                    || ||||||| 
Target 5' ccggccgcctAG-GGCTCAGa 3'
151 - 170 142.00 -12.60
2
miRNA  3' gaCCUCUCU---CUC--UCCGAGUCa 5'
            ||: |||   |:|  | |||||| 
Target 5' cgGGGTAGACCTGGGCTATGCTCAGt 3'
656 - 681 125.00 -16.20
3
miRNA  3' gacCUC--UCUCUCUCCGAGuca 5'
             |||  :|||:| |||||   
Target 5' gaaGAGGCGGAGGGCGGCTCcta 3'
477 - 499 124.00 -17.22
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN25990310 20 COSMIC
COSN16130002 53 COSMIC
COSN26441740 133 COSMIC
COSN8832585 420 COSMIC
COSN25269930 545 COSMIC
COSM7717056 772 COSMIC
COSM8960406 782 COSMIC
COSM5784662 800 COSMIC
COSM8908517 800 COSMIC
COSM9809954 805 COSMIC
COSM7192311 810 COSMIC
COSM8495443 810 COSMIC
COSM5548778 830 COSMIC
COSM9004221 834 COSMIC
COSM2740286 839 COSMIC
COSM8959442 863 COSMIC
COSM5516758 866 COSMIC
COSM9004685 867 COSMIC
COSM7440083 881 COSMIC
COSN26572385 951 COSMIC
COSN30673871 983 COSMIC
COSN31579355 999 COSMIC
COSN26554675 1000 COSMIC
COSN26637803 1011 COSMIC
COSN25907822 1028 COSMIC
COSN25807753 1085 COSMIC
COSN31521841 1106 COSMIC
COSN31561698 1111 COSMIC
COSN31779202 1114 COSMIC
COSN31539917 1149 COSMIC
COSN31489782 1161 COSMIC
COSN31535754 1165 COSMIC
COSN31591560 1237 COSMIC
COSN1714750 1262 COSMIC
COSN31556881 1285 COSMIC
COSN31522890 1296 COSMIC
COSN1193686 1315 COSMIC
COSN26161598 1366 COSMIC
COSN24967065 1407 COSMIC
COSN31546478 1414 COSMIC
COSN28852093 1423 COSMIC
COSN31782877 1440 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1337881858 2 dbSNP
rs1231924384 7 dbSNP
rs1329947776 11 dbSNP
rs1231561691 13 dbSNP
rs767107315 17 dbSNP
rs948181872 18 dbSNP
rs1345987196 19 dbSNP
rs199817588 20 dbSNP
rs1409633308 21 dbSNP
rs1348202138 23 dbSNP
rs752174617 27 dbSNP
rs757738920 28 dbSNP
rs1044595743 30 dbSNP
rs1391448373 33 dbSNP
rs1389467265 36 dbSNP
rs779287545 39 dbSNP
rs1251179379 40 dbSNP
rs1439294802 42 dbSNP
rs1196486103 45 dbSNP
rs1462900119 48 dbSNP
rs1006904320 50 dbSNP
rs1158098230 51 dbSNP
rs1454437658 53 dbSNP
rs905704649 57 dbSNP
rs34693238 59 dbSNP
rs1002752702 63 dbSNP
rs1184323945 68 dbSNP
rs1438463865 74 dbSNP
rs1266686695 78 dbSNP
rs1211924602 85 dbSNP
rs1337532304 86 dbSNP
rs1033476254 87 dbSNP
rs1183994844 90 dbSNP
rs957480581 101 dbSNP
rs1280918514 104 dbSNP
rs1239229894 111 dbSNP
rs1330165878 112 dbSNP
rs989718323 116 dbSNP
rs1418339250 121 dbSNP
rs1156463565 126 dbSNP
rs974162674 126 dbSNP
rs1020780606 133 dbSNP
rs1009937033 135 dbSNP
rs1158937337 136 dbSNP
rs966589252 138 dbSNP
rs982018777 146 dbSNP
rs1021357832 147 dbSNP
rs927904490 154 dbSNP
rs1254157771 157 dbSNP
rs529752687 160 dbSNP
rs543167667 175 dbSNP
rs563265354 176 dbSNP
rs532005208 179 dbSNP
rs1343805506 181 dbSNP
rs1300860145 184 dbSNP
rs974525269 185 dbSNP
rs990502557 188 dbSNP
rs909619102 197 dbSNP
rs1296777841 198 dbSNP
rs941152097 199 dbSNP
rs1428475610 204 dbSNP
rs1346915411 205 dbSNP
rs1432167064 210 dbSNP
rs1037189372 212 dbSNP
rs918779952 214 dbSNP
rs552035217 217 dbSNP
rs565680728 225 dbSNP
rs1401740002 231 dbSNP
rs1172066576 232 dbSNP
rs1390069177 236 dbSNP
rs1455636894 239 dbSNP
rs1051317047 241 dbSNP
rs528269406 242 dbSNP
rs1188019050 243 dbSNP
rs1474686820 245 dbSNP
rs1245263522 249 dbSNP
rs1289688784 250 dbSNP
rs987674251 254 dbSNP
rs1216921244 258 dbSNP
rs1007264819 259 dbSNP
rs1212661127 266 dbSNP
rs548320882 276 dbSNP
rs1273213420 279 dbSNP
rs998996130 280 dbSNP
rs1054502739 282 dbSNP
rs146819296 283 dbSNP
rs1480167711 284 dbSNP
rs973353117 285 dbSNP
rs1175291701 288 dbSNP
rs1446994278 297 dbSNP
rs1353399171 299 dbSNP
rs536718095 309 dbSNP
rs564831128 317 dbSNP
rs1376318825 320 dbSNP
rs948101269 327 dbSNP
rs1045158591 332 dbSNP
rs1444873717 335 dbSNP
rs1187679503 338 dbSNP
rs1472674218 346 dbSNP
rs927118462 354 dbSNP
rs1382840682 356 dbSNP
rs550030101 358 dbSNP
rs1057060212 361 dbSNP
rs768078281 363 dbSNP
rs1250664014 365 dbSNP
rs1171699131 366 dbSNP
rs1354502026 368 dbSNP
rs1273622593 370 dbSNP
rs1227606603 372 dbSNP
rs1460742681 374 dbSNP
rs570044205 378 dbSNP
rs1356304507 387 dbSNP
rs891742479 389 dbSNP
rs1440097356 390 dbSNP
rs1304973329 398 dbSNP
rs34210440 398 dbSNP
rs1010169319 407 dbSNP
rs773215080 414 dbSNP
rs1034867466 417 dbSNP
rs1475765132 418 dbSNP
rs1407021814 428 dbSNP
rs1452184513 430 dbSNP
rs959356179 439 dbSNP
rs1043080002 442 dbSNP
rs539070101 443 dbSNP
rs990881967 444 dbSNP
rs1313260089 445 dbSNP
rs909575721 453 dbSNP
rs962754746 454 dbSNP
rs1275018643 457 dbSNP
rs1306561323 458 dbSNP
rs1328289976 458 dbSNP
rs1215281196 462 dbSNP
rs753973733 470 dbSNP
rs114433624 478 dbSNP
rs1202102158 485 dbSNP
rs1028775446 490 dbSNP
rs954862488 491 dbSNP
rs918352623 493 dbSNP
rs934112631 494 dbSNP
rs1462286678 495 dbSNP
rs1363516603 497 dbSNP
rs1157389348 498 dbSNP
rs1009042385 502 dbSNP
rs1420450741 504 dbSNP
rs1257541477 509 dbSNP
rs1461651465 510 dbSNP
rs572730279 520 dbSNP
rs962241005 521 dbSNP
rs1254801445 523 dbSNP
rs867145257 528 dbSNP
rs1240935164 531 dbSNP
rs773819051 533 dbSNP
rs1464393356 544 dbSNP
rs535015443 547 dbSNP
rs1186616337 548 dbSNP
rs1419352837 551 dbSNP
rs1427261535 554 dbSNP
rs969455855 555 dbSNP
rs1430402832 560 dbSNP
rs943001295 561 dbSNP
rs1308035788 562 dbSNP
rs1054851835 566 dbSNP
rs981257841 567 dbSNP
rs564548872 570 dbSNP
rs1305723868 571 dbSNP
rs1010214320 573 dbSNP
rs938478398 576 dbSNP
rs1041757372 580 dbSNP
rs1287443665 589 dbSNP
rs1455713404 592 dbSNP
rs1345395080 593 dbSNP
rs574953732 598 dbSNP
rs913076820 600 dbSNP
rs1003326716 603 dbSNP
rs543481441 605 dbSNP
rs1043016148 607 dbSNP
rs1427803223 612 dbSNP
rs1034892386 615 dbSNP
rs904177595 616 dbSNP
rs959536482 620 dbSNP
rs1212727012 623 dbSNP
rs995884678 625 dbSNP
rs1012187373 627 dbSNP
rs760727327 630 dbSNP
rs1210348784 632 dbSNP
rs1323951949 636 dbSNP
rs1222706933 638 dbSNP
rs571733121 639 dbSNP
rs890179588 642 dbSNP
rs563270263 643 dbSNP
rs1448382398 647 dbSNP
rs972399205 648 dbSNP
rs1384263130 650 dbSNP
rs374887212 657 dbSNP
rs962189658 660 dbSNP
rs1301522232 662 dbSNP
rs1376924383 667 dbSNP
rs1173676440 669 dbSNP
rs576418511 674 dbSNP
rs757546619 679 dbSNP
rs200249502 687 dbSNP
rs918300252 689 dbSNP
rs955148096 692 dbSNP
rs1256467343 699 dbSNP
rs1480289457 701 dbSNP
rs754026580 707 dbSNP
rs545442390 716 dbSNP
rs911424280 720 dbSNP
rs1201088745 722 dbSNP
rs1338890183 724 dbSNP
rs1250123692 726 dbSNP
rs942928652 732 dbSNP
rs746171281 733 dbSNP
rs980822766 735 dbSNP
rs1293015436 736 dbSNP
rs990396638 742 dbSNP
rs758820067 744 dbSNP
rs542283173 745 dbSNP
rs1282498584 749 dbSNP
rs1446177662 752 dbSNP
rs1385389961 754 dbSNP
rs1323329552 755 dbSNP
rs878885443 757 dbSNP
rs1239008454 760 dbSNP
rs747272504 762 dbSNP
rs1236769344 764 dbSNP
rs1295734344 765 dbSNP
rs140957246 766 dbSNP
rs907287916 768 dbSNP
rs1251747272 769 dbSNP
rs1341401879 772 dbSNP
rs1458422702 774 dbSNP
rs781293447 776 dbSNP
rs1208048968 783 dbSNP
rs748181358 786 dbSNP
rs988223923 787 dbSNP
rs1468780578 788 dbSNP
rs913065572 789 dbSNP
rs1245840528 798 dbSNP
rs1448309151 799 dbSNP
rs938794707 802 dbSNP
rs1375231977 804 dbSNP
rs979073178 805 dbSNP
rs548205719 806 dbSNP
rs1163260866 808 dbSNP
rs1335229794 810 dbSNP
rs1395638243 810 dbSNP
rs1458577310 811 dbSNP
rs1273154916 817 dbSNP
rs1377655706 818 dbSNP
rs1337486327 819 dbSNP
rs1443590914 820 dbSNP
rs1318734505 821 dbSNP
rs1364733984 822 dbSNP
rs1234026818 823 dbSNP
rs1285157716 824 dbSNP
rs1382789630 825 dbSNP
rs759850736 826 dbSNP
rs1320066019 827 dbSNP
rs1346271948 828 dbSNP
rs1242479286 830 dbSNP
rs1413410532 834 dbSNP
rs1056681227 835 dbSNP
rs1333639056 836 dbSNP
rs1272523622 837 dbSNP
rs925915087 838 dbSNP
rs561894887 839 dbSNP
rs1462816066 842 dbSNP
rs764890641 843 dbSNP
rs1265780759 845 dbSNP
rs1157796037 846 dbSNP
rs1464174154 848 dbSNP
rs773083224 849 dbSNP
rs1263219234 854 dbSNP
rs1362317404 856 dbSNP
rs201177542 859 dbSNP
rs1440454368 860 dbSNP
rs1187391865 861 dbSNP
rs73981074 865 dbSNP
rs770892580 866 dbSNP
rs1016817096 868 dbSNP
rs1388437267 871 dbSNP
rs897990782 873 dbSNP
rs898417830 875 dbSNP
rs774129267 878 dbSNP
rs759219352 881 dbSNP
rs767103603 885 dbSNP
rs993830647 886 dbSNP
rs1280976553 887 dbSNP
rs1292556210 889 dbSNP
rs1025349886 892 dbSNP
rs1234845748 895 dbSNP
rs1286214835 905 dbSNP
rs1316195293 908 dbSNP
rs955095973 910 dbSNP
rs752181202 911 dbSNP
rs1481964095 915 dbSNP
rs986592118 916 dbSNP
rs1209529514 917 dbSNP
rs1473274298 921 dbSNP
rs1317327216 922 dbSNP
rs1258756309 923 dbSNP
rs1383046254 924 dbSNP
rs1362743608 925 dbSNP
rs1476464225 927 dbSNP
rs1180728856 931 dbSNP
rs1028304652 936 dbSNP
rs1411648959 937 dbSNP
rs1191848582 938 dbSNP
rs760113790 939 dbSNP
rs1018459821 944 dbSNP
rs1420103488 948 dbSNP
rs1455930845 950 dbSNP
rs964217997 953 dbSNP
rs905423296 955 dbSNP
rs1445692794 962 dbSNP
rs1002883759 972 dbSNP
rs765313154 973 dbSNP
rs914792333 974 dbSNP
rs1034976781 980 dbSNP
rs946334452 983 dbSNP
rs977378594 985 dbSNP
rs1235899774 990 dbSNP
rs1368179860 991 dbSNP
rs1220882784 993 dbSNP
rs1269576902 1000 dbSNP
rs928661403 1006 dbSNP
rs1438712156 1013 dbSNP
rs938699414 1015 dbSNP
rs1298595019 1019 dbSNP
rs1055854858 1020 dbSNP
rs967597350 1021 dbSNP
rs1446674888 1025 dbSNP
rs1436714682 1027 dbSNP
rs894558467 1031 dbSNP
rs530844746 1038 dbSNP
rs925792247 1038 dbSNP
rs1384671063 1049 dbSNP
rs550233963 1058 dbSNP
rs1310767297 1063 dbSNP
rs898408383 1071 dbSNP
rs1212382334 1073 dbSNP
rs1312327888 1075 dbSNP
rs911557134 1083 dbSNP
rs1212673407 1084 dbSNP
rs1341412306 1088 dbSNP
rs1161559411 1089 dbSNP
rs994114365 1094 dbSNP
rs1278556719 1098 dbSNP
rs1232494271 1099 dbSNP
rs1355035009 1100 dbSNP
rs944410584 1101 dbSNP
rs920000802 1104 dbSNP
rs1359749042 1109 dbSNP
rs1410271754 1113 dbSNP
rs1408664247 1114 dbSNP
rs1422314520 1115 dbSNP
rs1171798584 1116 dbSNP
rs1475115260 1120 dbSNP
rs1025297407 1121 dbSNP
rs879207307 1124 dbSNP
rs1008323697 1128 dbSNP
rs1201857628 1135 dbSNP
rs1315370943 1140 dbSNP
rs1381367242 1141 dbSNP
rs1258686329 1142 dbSNP
rs1243179225 1145 dbSNP
rs1332495044 1149 dbSNP
rs1272383861 1150 dbSNP
rs1294906584 1152 dbSNP
rs1230183434 1153 dbSNP
rs1380196888 1159 dbSNP
rs770858828 1161 dbSNP
rs905360229 1162 dbSNP
rs1002455273 1163 dbSNP
rs1403060249 1166 dbSNP
rs1332699555 1171 dbSNP
rs138625473 1184 dbSNP
rs539137740 1186 dbSNP
rs964138980 1191 dbSNP
rs1357676922 1192 dbSNP
rs1423986823 1199 dbSNP
rs766348360 1201 dbSNP
rs1465552170 1202 dbSNP
rs1406841258 1207 dbSNP
rs1313576382 1214 dbSNP
rs148898291 1219 dbSNP
rs1011745684 1223 dbSNP
rs1021776020 1224 dbSNP
rs1212917919 1233 dbSNP
rs1416543885 1233 dbSNP
rs1035304830 1234 dbSNP
rs896473579 1244 dbSNP
rs1286428118 1245 dbSNP
rs751534268 1246 dbSNP
rs1322525063 1247 dbSNP
rs1283890012 1252 dbSNP
rs1020983976 1255 dbSNP
rs967583551 1255 dbSNP
rs1224156596 1256 dbSNP
rs759039705 1256 dbSNP
rs1308607645 1257 dbSNP
rs1310085619 1258 dbSNP
rs1233183429 1262 dbSNP
rs1379303600 1265 dbSNP
rs767025491 1265 dbSNP
rs765758533 1269 dbSNP
rs143628855 1271 dbSNP
rs1295619028 1272 dbSNP
rs1232832359 1273 dbSNP
rs953374040 1275 dbSNP
rs1344223105 1276 dbSNP
rs750881640 1276 dbSNP
rs752344306 1276 dbSNP
rs911840005 1277 dbSNP
rs758837168 1278 dbSNP
rs928901931 1278 dbSNP
rs1481141806 1280 dbSNP
rs959996753 1281 dbSNP
rs1179325283 1283 dbSNP
rs1380314314 1285 dbSNP
rs965666753 1286 dbSNP
rs1423258407 1287 dbSNP
rs971683016 1287 dbSNP
rs758730057 1294 dbSNP
rs1737962 1298 dbSNP
rs550868299 1299 dbSNP
rs1485456923 1301 dbSNP
rs1335263200 1307 dbSNP
rs779177135 1311 dbSNP
rs1305990637 1314 dbSNP
rs991901772 1317 dbSNP
rs915994704 1319 dbSNP
rs747571235 1322 dbSNP
rs930378756 1323 dbSNP
rs1049320806 1325 dbSNP
rs926801708 1325 dbSNP
rs938188040 1327 dbSNP
rs942143277 1327 dbSNP
rs1304124042 1339 dbSNP
rs1387703106 1340 dbSNP
rs1483973497 1354 dbSNP
rs780446053 1354 dbSNP
rs1361616081 1365 dbSNP
rs1287500412 1376 dbSNP
rs1401408178 1382 dbSNP
rs1056711112 1395 dbSNP
rs780654029 1395 dbSNP
rs1432385177 1401 dbSNP
rs896715727 1401 dbSNP
rs1176791185 1404 dbSNP
rs1427858352 1407 dbSNP
rs1259335883 1412 dbSNP
rs1195611852 1414 dbSNP
rs1491527167 1420 dbSNP
rs370601753 1420 dbSNP
rs1210233586 1421 dbSNP
rs1491489489 1421 dbSNP
rs373004318 1421 dbSNP
rs754405451 1421 dbSNP
rs774837774 1421 dbSNP
rs1491285770 1422 dbSNP
rs374829984 1422 dbSNP
rs1172521467 1423 dbSNP
rs1313660650 1423 dbSNP
rs1371303595 1423 dbSNP
rs1403638869 1423 dbSNP
rs1424598478 1423 dbSNP
rs1478057635 1423 dbSNP
rs1491274388 1423 dbSNP
rs1491366426 1423 dbSNP
rs1491442822 1423 dbSNP
rs34061744 1423 dbSNP
rs397718365 1423 dbSNP
rs573904022 1423 dbSNP
rs57663061 1423 dbSNP
rs796900175 1423 dbSNP
rs878861759 1423 dbSNP
rs959750807 1423 dbSNP
rs1326576226 1424 dbSNP
rs1227323539 1426 dbSNP
rs1268981051 1428 dbSNP
rs1009835066 1429 dbSNP
rs1201138647 1432 dbSNP
rs79080059 1438 dbSNP
rs397856773 1439 dbSNP
rs80057141 1440 dbSNP
rs1256770033 1441 dbSNP
rs1224538806 1443 dbSNP
rs1200898920 1444 dbSNP
rs1262689953 1446 dbSNP
rs1321683598 1447 dbSNP
rs1319120456 1453 dbSNP
rs1042357511 1456 dbSNP
rs1231017177 1457 dbSNP
rs1206903047 1458 dbSNP
rs1341921621 1458 dbSNP
rs1390362372 1463 dbSNP
rs1262503462 1468 dbSNP
rs1333357985 1470 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293
Disease 10743.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "HITS-CLIP data was present in GSM714643. RNA binding protein: AGO2. Condition:completeT1 ...

- Kishore S; Jaskiewicz L; Burger L; Hausser et al., 2011, Nature methods.

Article - Kishore S; Jaskiewicz L; Burger L; Hausser et al.
- Nature methods, 2011
Cross-linking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins. We developed a method for CLIP data analysis, and applied it to compare CLIP with photoactivatable ribonucleoside-enhanced CLIP (PAR-CLIP) and to uncover how differences in cross-linking and ribonuclease digestion affect the identified sites. We found only small differences in accuracies of these methods in identifying binding sites of HuR, which binds low-complexity sequences, and Argonaute 2, which has a complex binding specificity. We found that cross-link-induced mutations led to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites. This bias can be substantially reduced by milder nuclease digestion conditions.
LinkOut: [PMID: 21572407]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions Cardiac Tissues
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM2202480. RNA binding protein: AGO2. Condition:S5_LV_36yo_Male_AGO2_bound_RNA ...

- Spengler RM; Zhang X; Cheng C; McLendon JM; et al., 2016, Nucleic acids research.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' gaccucucUCU---CUCCGAGUCa 5'
                  |||   | ||| | | 
Target 5' --------AGACUUGCGGCCCCGg 3'
1 - 16
Article - Spengler RM; Zhang X; Cheng C; McLendon JM; et al.
- Nucleic acids research, 2016
MicroRNAs (miRs) have emerged as key biological effectors in human health and disease. These small noncoding RNAs are incorporated into Argonaute (Ago) proteins, where they direct post-transcriptional gene silencing via base-pairing with target transcripts. Although miRs have become intriguing biological entities and attractive therapeutic targets, the translational impacts of miR research remain limited by a paucity of empirical miR targeting data, particularly in human primary tissues. Here, to improve our understanding of the diverse roles miRs play in cardiovascular function and disease, we applied high-throughput methods to globally profile miR:target interactions in human heart tissues. We deciphered Ago2:RNA interactions using crosslinking immunoprecipitation coupled with high-throughput sequencing (HITS-CLIP) to generate the first transcriptome-wide map of miR targeting events in human myocardium, detecting 4000 cardiac Ago2 binding sites across >2200 target transcripts. Our initial exploration of this interactome revealed an abundance of miR target sites in gene coding regions, including several sites pointing to new miR-29 functions in regulating cardiomyocyte calcium, growth and metabolism. Also, we uncovered several clinically-relevant interactions involving common genetic variants that alter miR targeting events in cardiomyopathy-associated genes. Overall, these data provide a critical resource for bolstering translational miR research in heart, and likely beyond.
LinkOut: [PMID: 27418678]
CLIP-seq Support 1 for dataset GSM714643
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repB
Location of target site ENST00000353383.1 | 3UTR | GACUUGCGGCCCCGGGUUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
77 hsa-miR-6751-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT130738 GATAD2B GATA zinc finger domain containing 2B 2 4
MIRT134924 CCND2 cyclin D2 2 2
MIRT273034 ZBTB18 zinc finger and BTB domain containing 18 2 2
MIRT276645 KPNA3 karyopherin subunit alpha 3 2 6
MIRT446531 OAS2 2'-5'-oligoadenylate synthetase 2 2 2
MIRT456268 TDRKH tudor and KH domain containing 2 12
MIRT494454 BTG2 BTG anti-proliferation factor 2 2 2
MIRT494965 USP46 ubiquitin specific peptidase 46 2 2
MIRT496689 KREMEN1 kringle containing transmembrane protein 1 2 2
MIRT496697 RGS11 regulator of G protein signaling 11 2 2
MIRT504376 IRF4 interferon regulatory factor 4 2 6
MIRT510980 PFN2 profilin 2 2 6
MIRT512548 MFN2 mitofusin 2 2 6
MIRT513639 TP53INP2 tumor protein p53 inducible nuclear protein 2 2 2
MIRT514016 CAMSAP1 calmodulin regulated spectrin associated protein 1 2 4
MIRT514074 MTRNR2L6 MT-RNR2-like 6 2 2
MIRT515300 C15orf38-AP3S2 C15orf38-AP3S2 readthrough 2 4
MIRT517285 AP3S2 adaptor related protein complex 3 sigma 2 subunit 2 4
MIRT519075 KCNK6 potassium two pore domain channel subfamily K member 6 2 2
MIRT520779 TCF23 transcription factor 23 2 2
MIRT522485 MFSD9 major facilitator superfamily domain containing 9 2 2
MIRT528856 PKP1 plakophilin 1 2 2
MIRT529081 PATE2 prostate and testis expressed 2 2 2
MIRT531209 PLA2G4D phospholipase A2 group IVD 2 2
MIRT533988 TAB3 TGF-beta activated kinase 1 and MAP3K7 binding protein 3 2 2
MIRT537024 GRIN2B glutamate ionotropic receptor NMDA type subunit 2B 2 2
MIRT537498 FAM168B family with sequence similarity 168 member B 2 2
MIRT553125 UBE2Z ubiquitin conjugating enzyme E2 Z 2 2
MIRT555591 PIP5K1C phosphatidylinositol-4-phosphate 5-kinase type 1 gamma 2 2
MIRT556370 LUZP1 leucine zipper protein 1 2 2
MIRT569745 C2orf71 chromosome 2 open reading frame 71 2 2
MIRT570149 DNAJC10 DnaJ heat shock protein family (Hsp40) member C10 2 2
MIRT571243 FADS6 fatty acid desaturase 6 2 2
MIRT573065 TRIB1 tribbles pseudokinase 1 2 2
MIRT575533 Map4 microtubule-associated protein 4 2 2
MIRT575777 Tnfrsf10b tumor necrosis factor receptor superfamily, member 10b 2 2
MIRT616558 ZNF512B zinc finger protein 512B 2 2
MIRT624851 ABI2 abl interactor 2 2 2
MIRT630078 GRWD1 glutamate rich WD repeat containing 1 2 2
MIRT631479 KLHL21 kelch like family member 21 2 2
MIRT632173 CCL22 C-C motif chemokine ligand 22 2 2
MIRT638397 QSOX2 quiescin sulfhydryl oxidase 2 2 4
MIRT641192 ISG20L2 interferon stimulated exonuclease gene 20 like 2 2 2
MIRT642562 TEX9 testis expressed 9 2 2
MIRT642935 KRTAP5-9 keratin associated protein 5-9 2 2
MIRT649703 ZNF175 zinc finger protein 175 2 2
MIRT650437 CPXM2 carboxypeptidase X, M14 family member 2 2 2
MIRT652113 TRUB2 TruB pseudouridine synthase family member 2 2 2
MIRT652273 TOMM20 translocase of outer mitochondrial membrane 20 2 2
MIRT655215 PFKM phosphofructokinase, muscle 2 2
MIRT682778 ZNF852 zinc finger protein 852 2 2
MIRT683001 MUC20 mucin 20, cell surface associated 2 2
MIRT684320 GTF3C4 general transcription factor IIIC subunit 4 2 2
MIRT689435 CYB561 cytochrome b561 2 2
MIRT693847 ZNF107 zinc finger protein 107 2 2
MIRT696715 TAX1BP3 Tax1 binding protein 3 2 2
MIRT698597 TEX261 testis expressed 261 2 2
MIRT699973 RREB1 ras responsive element binding protein 1 2 2
MIRT703310 GFPT1 glutamine--fructose-6-phosphate transaminase 1 2 2
MIRT706796 RAI1 retinoic acid induced 1 2 2
MIRT709004 CD109 CD109 molecule 2 2
MIRT709181 TBC1D10B TBC1 domain family member 10B 2 2
MIRT709835 PAQR7 progestin and adipoQ receptor family member 7 2 2
MIRT711627 CORO1C coronin 1C 2 2
MIRT712634 RNF103-CHMP3 RNF103-CHMP3 readthrough 2 2
MIRT713694 CYB5R4 cytochrome b5 reductase 4 2 2
MIRT713752 SLC9A8 solute carrier family 9 member A8 2 2
MIRT714908 CHMP3 charged multivesicular body protein 3 2 2
MIRT716371 CBLL1 Cbl proto-oncogene like 1 2 2
MIRT718303 XPOT exportin for tRNA 2 2
MIRT718713 ANKRD18A ankyrin repeat domain 18A 2 2
MIRT718740 ATP9A ATPase phospholipid transporting 9A (putative) 2 2
MIRT719441 NPTX2 neuronal pentraxin 2 2 2
MIRT720896 OTUD4 OTU deubiquitinase 4 2 2
MIRT722448 RXFP4 relaxin/insulin like family peptide receptor 4 2 2
MIRT723882 VKORC1 vitamin K epoxide reductase complex subunit 1 2 2
MIRT724586 SYNJ2BP synaptojanin 2 binding protein 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-6751 Cisplatin 5460033 NSC119875 approved sensitive Low Ovarian Cancer cell line (A2780)
hsa-mir-6751 Triptolide 107985 NSC163062 sensitive Low Ovarian Cancer cell line (A2780)

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