pre-miRNA Information
pre-miRNA hsa-mir-6819   
Genomic Coordinates chr22: 36286847 - 36286907
Description Homo sapiens miR-6819 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-6819-3p
Sequence 41| AAGCCUCUGUCCCCACCCCAG |61
Evidence Experimental
Experiments Meta-analysis
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1279530967 2 dbSNP
rs967579979 3 dbSNP
rs776891214 4 dbSNP
rs771166635 8 dbSNP
rs747037324 9 dbSNP
rs879248090 11 dbSNP
rs1485325191 12 dbSNP
rs778157316 16 dbSNP
Putative Targets

Gene Information
Gene Symbol PPP1R26   
Synonyms KIAA0649, NRBE3
Description protein phosphatase 1 regulatory subunit 26
Transcript NM_014811   
Expression
Putative miRNA Targets on PPP1R26
3'UTR of PPP1R26
(miRNA target sites are highlighted)
>PPP1R26|NM_014811|3'UTR
   1 GCCCTCGAGCTGTGGGTTCGCGTCCTGGGTTGCGTGCATTCGTGGAAAGCGGCGTAGCCGTGCGTGTGTGTGATGGTTCC
  81 GTGGCTGCAAGGAAGGGAAACAGTCTATTATACATAGCCCTGTATATATGTACACCAACATGAAACTTTTATTTAACAGA
 161 CGTGTCCTGGTAAATATGATTTTTGTAGCTTTTTGTAAATTATTTAAAGTGATGTAAAAGATATTTTTGGAAAATACTGT
 241 TGTTCAATTTTGTAGGGTGTTCCTAACTGCAGTTTTCTGTGTTCTGCATACAAGTCTTAGCTTAGGAAACATTTGGTTCT
 321 TACCATCACAGCCAGGTTCACAGAGGCTCTGATGCTTTTTGGTTGATTGCTGGTGAGAATGGCCGGCGGTGGCTGCAGTG
 401 GTAGCCTGAGGAAGGCCAAGCTGCCCTCCCTGGGAATCACTCAGATGCCCCAAGATGTCCGTTGGGAAGCTCCCAGGACA
 481 GCACTTTTTATACAGAGGACACCGCCTCGGCCCCACGTCCTTAGAGGCCAGAGCACATCTGAAAACTGCAATCACAGCCG
 561 TCCGCTGGAAAAACGTTTCGAAGCACAGTGGCCAGCGAGCGAGCACGTGGCTACTCCCTGTTGCATGTCAAATCCACACA
 641 GATGTCAGCGGCAGCTGCTCGGCAGCCCAGCCCTGGGCCTGGGTGGGTTCATGTCCAATCTTGTTCGATCACTAGATGAT
 721 TCTAACATCGAAATAAACCTCTTTTTATATGGCAAAAAAAAAAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' gaccccaccccUGUCUCCGAa 5'
                     ||||||||| 
Target 5' cagccaggttcACAGAGGCTc 3'
329 - 349 150.00 -15.80
2
miRNA  3' gaccccaccccuGUCUCCGaa 5'
                      :||||||  
Target 5' gccccacgtcctTAGAGGCca 3'
510 - 530 121.00 -8.70
3
miRNA  3' gaccccaccccUGUCUCCgaa 5'
                     |||||||   
Target 5' gcactttttatACAGAGGaca 3'
481 - 501 110.00 -10.12
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30466308 5 COSMIC
COSN26990128 43 COSMIC
COSN30493096 58 COSMIC
COSN30448083 60 COSMIC
COSN30189406 61 COSMIC
COSN26990126 65 COSMIC
COSN30498787 81 COSMIC
COSN31604064 82 COSMIC
COSN26498634 85 COSMIC
COSN30139441 127 COSMIC
COSN30171044 132 COSMIC
COSN31544045 190 COSMIC
COSN26958621 201 COSMIC
COSN28643749 247 COSMIC
COSN19661118 349 COSMIC
COSN28651104 394 COSMIC
COSN8520239 401 COSMIC
COSN31513285 439 COSMIC
COSN1375201 462 COSMIC
COSN31534170 490 COSMIC
COSN30113548 580 COSMIC
COSN30118438 589 COSMIC
COSN26636891 608 COSMIC
COSN30127360 630 COSMIC
COSN31584213 661 COSMIC
COSN30545360 690 COSMIC
COSN28201106 707 COSMIC
COSN19247607 716 COSMIC
COSN31572179 731 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs761529603 6 dbSNP
rs767133883 7 dbSNP
rs755000703 8 dbSNP
rs1357308507 11 dbSNP
rs550183464 13 dbSNP
rs1461861624 16 dbSNP
rs779576319 17 dbSNP
rs754335260 19 dbSNP
rs755563615 20 dbSNP
rs143148284 21 dbSNP
rs748476519 22 dbSNP
rs758719512 23 dbSNP
rs1387464248 25 dbSNP
rs1308126478 28 dbSNP
rs778091902 34 dbSNP
rs747284168 35 dbSNP
rs1165364347 36 dbSNP
rs1358956750 39 dbSNP
rs771103289 42 dbSNP
rs1299390361 43 dbSNP
rs1384432586 46 dbSNP
rs1398523699 47 dbSNP
rs776917938 49 dbSNP
rs749170470 51 dbSNP
rs768583220 52 dbSNP
rs1319335296 54 dbSNP
rs955879802 55 dbSNP
rs529401602 60 dbSNP
rs989871786 61 dbSNP
rs1158342628 64 dbSNP
rs1021785648 65 dbSNP
rs774841209 72 dbSNP
rs1247915603 75 dbSNP
rs1478107213 81 dbSNP
rs964466554 82 dbSNP
rs1192267274 88 dbSNP
rs573634661 90 dbSNP
rs1445131385 94 dbSNP
rs1284847558 102 dbSNP
rs778294508 103 dbSNP
rs1222692760 114 dbSNP
rs1361154242 118 dbSNP
rs1312229859 125 dbSNP
rs1455940013 131 dbSNP
rs1286953910 132 dbSNP
rs1227265325 141 dbSNP
rs1161854410 147 dbSNP
rs1379053127 147 dbSNP
rs974534003 161 dbSNP
rs547908979 162 dbSNP
rs566048724 163 dbSNP
rs1425470500 174 dbSNP
rs1367705616 190 dbSNP
rs34512090 190 dbSNP
rs1162717648 201 dbSNP
rs1404959086 206 dbSNP
rs983760329 210 dbSNP
rs907807245 214 dbSNP
rs371864513 221 dbSNP
rs1474389845 240 dbSNP
rs41299044 247 dbSNP
rs1490727053 248 dbSNP
rs1289195825 257 dbSNP
rs1220157295 260 dbSNP
rs1307631269 262 dbSNP
rs1274315977 263 dbSNP
rs1216766667 264 dbSNP
rs1339106882 268 dbSNP
rs1038404570 270 dbSNP
rs757636770 275 dbSNP
rs147034791 279 dbSNP
rs948826432 289 dbSNP
rs1437295250 291 dbSNP
rs1278813092 292 dbSNP
rs1292066043 293 dbSNP
rs1457469845 294 dbSNP
rs1044516332 297 dbSNP
rs1172643668 300 dbSNP
rs1463957381 301 dbSNP
rs907369902 313 dbSNP
rs1348586053 325 dbSNP
rs1229946209 331 dbSNP
rs747131479 333 dbSNP
rs1264809089 342 dbSNP
rs1190337172 343 dbSNP
rs745477362 348 dbSNP
rs3827828 349 dbSNP
rs1032337327 350 dbSNP
rs3827829 354 dbSNP
rs1258020731 358 dbSNP
rs1291651653 368 dbSNP
rs1011625186 373 dbSNP
rs1326188571 383 dbSNP
rs774915400 386 dbSNP
rs964432707 388 dbSNP
rs974503066 389 dbSNP
rs111701898 394 dbSNP
rs746101401 412 dbSNP
rs1444707159 427 dbSNP
rs954507379 429 dbSNP
rs1470830475 431 dbSNP
rs573350156 432 dbSNP
rs115289342 440 dbSNP
rs1419249155 456 dbSNP
rs552993759 461 dbSNP
rs1472710820 462 dbSNP
rs1161624950 463 dbSNP
rs1238103563 473 dbSNP
rs541279820 495 dbSNP
rs1463063607 503 dbSNP
rs907774241 504 dbSNP
rs1233028361 505 dbSNP
rs1011532730 506 dbSNP
rs1309486136 507 dbSNP
rs941963592 509 dbSNP
rs1041669483 510 dbSNP
rs754343655 511 dbSNP
rs1376339160 514 dbSNP
rs775987132 517 dbSNP
rs999377471 518 dbSNP
rs761640806 521 dbSNP
rs919942522 522 dbSNP
rs1339639213 528 dbSNP
rs1156534800 529 dbSNP
rs1242359391 547 dbSNP
rs1035332278 548 dbSNP
rs181913872 560 dbSNP
rs767325702 561 dbSNP
rs1426035050 562 dbSNP
rs1356641641 564 dbSNP
rs1194924695 565 dbSNP
rs1271826634 571 dbSNP
rs1483790359 572 dbSNP
rs571920687 573 dbSNP
rs907337088 575 dbSNP
rs1353276591 578 dbSNP
rs776736936 580 dbSNP
rs576787965 581 dbSNP
rs1338592312 588 dbSNP
rs973746590 590 dbSNP
rs1370365679 592 dbSNP
rs1382556706 594 dbSNP
rs544173857 595 dbSNP
rs562053069 597 dbSNP
rs1011848875 598 dbSNP
rs1365845196 601 dbSNP
rs987078901 602 dbSNP
rs141302962 608 dbSNP
rs1431767138 619 dbSNP
rs1187545891 622 dbSNP
rs34558834 629 dbSNP
rs1308497406 637 dbSNP
rs1265719564 638 dbSNP
rs755918584 639 dbSNP
rs755491905 640 dbSNP
rs942919799 641 dbSNP
rs547476125 643 dbSNP
rs1040235483 646 dbSNP
rs914667949 650 dbSNP
rs559767239 651 dbSNP
rs1292826423 652 dbSNP
rs1211688523 653 dbSNP
rs533279911 655 dbSNP
rs1041720360 660 dbSNP
rs995865863 661 dbSNP
rs759759144 662 dbSNP
rs371517001 672 dbSNP
rs1227209679 673 dbSNP
rs11554545 676 dbSNP
rs1399212406 679 dbSNP
rs1345729200 692 dbSNP
rs551540251 693 dbSNP
rs373481759 696 dbSNP
rs1056419221 698 dbSNP
rs1343612612 699 dbSNP
rs896390784 704 dbSNP
rs150798341 707 dbSNP
rs1483219360 708 dbSNP
rs963598405 717 dbSNP
rs1269846786 725 dbSNP
rs1012084517 728 dbSNP
rs1023860408 730 dbSNP
rs962471735 731 dbSNP
rs970031504 734 dbSNP
rs1443419452 739 dbSNP
rs995277546 744 dbSNP
rs1025384867 745 dbSNP
rs765234250 748 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HeLa
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in Chi_ControlA_2A8_130_50. RNA binding protein: AGO. Condition:HeLa cell Control A HITS-CLIP data was present in Chi_ControlB_2A8_130_50. RNA binding protein: AGO. Condition:HeLa cell Control B ...

- Chi SW; Zang JB; Mele A; Darnell RB, 2009, Nature.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' gaccccaccccUGUCUCCGAa 5'
                     ||||||||| 
Target 5' ---ccagguucACAGAGGCU- 3'
1 - 17
Article - Chi SW; Zang JB; Mele A; Darnell RB
- Nature, 2009
MicroRNAs (miRNAs) have critical roles in the regulation of gene expression; however, as miRNA activity requires base pairing with only 6-8 nucleotides of messenger RNA, predicting target mRNAs is a major challenge. Recently, high-throughput sequencing of RNAs isolated by crosslinking immunoprecipitation (HITS-CLIP) has identified functional protein-RNA interaction sites. Here we use HITS-CLIP to covalently crosslink native argonaute (Ago, also called Eif2c) protein-RNA complexes in mouse brain. This produced two simultaneous data sets-Ago-miRNA and Ago-mRNA binding sites-that were combined with bioinformatic analysis to identify interaction sites between miRNA and target mRNA. We validated genome-wide interaction maps for miR-124, and generated additional maps for the 20 most abundant miRNAs present in P13 mouse brain. Ago HITS-CLIP provides a general platform for exploring the specificity and range of miRNA action in vivo, and identifies precise sequences for targeting clinically relevant miRNA-mRNA interactions.
LinkOut: [PMID: 19536157]
CLIP-seq Support 1 for dataset Chi_ControlA_2A8_130_50
Method / RBP HITS-CLIP / AGO
Cell line / Condition HeLa / HeLa cell Control A
Location of target site ENST00000605286.1 | 3UTR | CCAGGUUCACAGAGGCU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 19536157 / Chi_HITSCLIP
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset Chi_ControlB_2A8_130_50
Method / RBP HITS-CLIP / AGO
Cell line / Condition HeLa / HeLa cell Control B
Location of target site ENST00000605286.1 | 3UTR | CCAGGUUCACAGAGGCU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 19536157 / Chi_HITSCLIP
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
108 hsa-miR-6819-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT358318 PANK3 pantothenate kinase 3 2 2
MIRT454719 UBQLNL ubiquilin like 2 2
MIRT471362 PEG10 paternally expressed 10 2 2
MIRT478101 DLG5 discs large MAGUK scaffold protein 5 2 4
MIRT495554 GOLGA6L4 golgin A6 family-like 4 2 2
MIRT495587 GOLGA6L10 golgin A6 family-like 10 2 2
MIRT508315 RPL18 ribosomal protein L18 2 4
MIRT529183 ADAM33 ADAM metallopeptidase domain 33 2 2
MIRT532035 FHDC1 FH2 domain containing 1 2 2
MIRT545131 ANXA5 annexin A5 2 2
MIRT567288 HNRNPL heterogeneous nuclear ribonucleoprotein L 2 2
MIRT568094 CEBPG CCAAT/enhancer binding protein gamma 2 2
MIRT573291 DLX4 distal-less homeobox 4 2 2
MIRT575169 Fam120c family with sequence similarity 120, member C 2 2
MIRT609495 DNASE1L3 deoxyribonuclease 1 like 3 2 2
MIRT611264 EHD3 EH domain containing 3 2 2
MIRT613580 POC5 POC5 centriolar protein 2 2
MIRT616520 C9orf170 chromosome 9 open reading frame 170 2 2
MIRT617098 ZNF667 zinc finger protein 667 2 2
MIRT618268 DDX51 DEAD-box helicase 51 2 2
MIRT618294 ZNF682 zinc finger protein 682 2 2
MIRT618617 SHOX short stature homeobox 2 2
MIRT619741 SRFBP1 serum response factor binding protein 1 2 2
MIRT619784 NRIP2 nuclear receptor interacting protein 2 2 2
MIRT621119 SP110 SP110 nuclear body protein 2 2
MIRT622530 RAD51 RAD51 recombinase 2 2
MIRT623088 NME6 NME/NM23 nucleoside diphosphate kinase 6 2 2
MIRT623938 FKBP14 FK506 binding protein 14 2 2
MIRT624389 CD84 CD84 molecule 2 2
MIRT624860 ABI2 abl interactor 2 2 2
MIRT628752 TRPV2 transient receptor potential cation channel subfamily V member 2 2 2
MIRT632243 VTA1 vesicle trafficking 1 2 2
MIRT632987 E2F2 E2F transcription factor 2 2 2
MIRT633695 RBM43 RNA binding motif protein 43 2 2
MIRT633766 CENPBD1 CENPB DNA-binding domain containing 1 2 2
MIRT633808 ZNF91 zinc finger protein 91 2 2
MIRT638914 CBLN2 cerebellin 2 precursor 2 2
MIRT641298 SLAMF1 signaling lymphocytic activation molecule family member 1 2 2
MIRT642123 SRCAP Snf2 related CREBBP activator protein 2 2
MIRT642179 HEBP2 heme binding protein 2 2 2
MIRT642617 CDKN3 cyclin dependent kinase inhibitor 3 2 2
MIRT643325 TMEM151B transmembrane protein 151B 2 2
MIRT644534 TMEM134 transmembrane protein 134 2 2
MIRT645820 OMA1 OMA1 zinc metallopeptidase 2 2
MIRT646093 MGST3 microsomal glutathione S-transferase 3 2 2
MIRT646861 SLC35E4 solute carrier family 35 member E4 2 2
MIRT647466 DZIP1L DAZ interacting zinc finger protein 1 like 2 2
MIRT647702 NADSYN1 NAD synthetase 1 2 2
MIRT648082 ZMIZ2 zinc finger MIZ-type containing 2 2 2
MIRT648547 TMEM169 transmembrane protein 169 2 2
MIRT648690 AP1M1 adaptor related protein complex 1 mu 1 subunit 2 2
MIRT649747 GNB5 G protein subunit beta 5 2 2
MIRT650154 ZNF426 zinc finger protein 426 2 2
MIRT650450 CPXM2 carboxypeptidase X, M14 family member 2 2 2
MIRT650943 CTNS cystinosin, lysosomal cystine transporter 2 2
MIRT651544 WNK1 WNK lysine deficient protein kinase 1 2 2
MIRT652304 TNRC6B trinucleotide repeat containing 6B 2 2
MIRT652890 SYVN1 synoviolin 1 2 2
MIRT654222 RNF19B ring finger protein 19B 2 2
MIRT654676 PSMB5 proteasome subunit beta 5 2 2
MIRT658249 FAXC failed axon connections homolog 2 2
MIRT658363 FAM65B RHO family interacting cell polarization regulator 2 2 2
MIRT659622 CELF1 CUGBP Elav-like family member 1 2 2
MIRT660171 BNIP3L BCL2 interacting protein 3 like 2 2
MIRT660634 ANKRD52 ankyrin repeat domain 52 2 2
MIRT662428 TMCO1 transmembrane and coiled-coil domains 1 2 2
MIRT662984 PAK3 p21 (RAC1) activated kinase 3 2 2
MIRT663939 ZNF554 zinc finger protein 554 2 2
MIRT666960 PKHD1 PKHD1, fibrocystin/polyductin 2 2
MIRT667945 HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 2 2
MIRT668847 CYCS cytochrome c, somatic 2 2
MIRT671792 RGS17 regulator of G protein signaling 17 2 2
MIRT672382 RPL37 ribosomal protein L37 2 2
MIRT673516 TNFAIP8L1 TNF alpha induced protein 8 like 1 2 4
MIRT674716 FAM73A mitoguardin 1 2 2
MIRT676352 KLF8 Kruppel like factor 8 2 2
MIRT677820 MRPS10 mitochondrial ribosomal protein S10 2 2
MIRT678440 PDE4C phosphodiesterase 4C 2 2
MIRT678499 ARHGEF39 Rho guanine nucleotide exchange factor 39 2 2
MIRT679243 LRP10 LDL receptor related protein 10 2 2
MIRT693607 SLC39A1 solute carrier family 39 member 1 2 2
MIRT695927 ZNF174 zinc finger protein 174 2 2
MIRT697987 TSPAN6 tetraspanin 6 2 2
MIRT700821 PHLDA2 pleckstrin homology like domain family A member 2 2 2
MIRT701350 NR4A3 nuclear receptor subfamily 4 group A member 3 2 2
MIRT702348 KLHL7 kelch like family member 7 2 2
MIRT703387 GABPB1 GA binding protein transcription factor beta subunit 1 2 2
MIRT703883 ERBB2IP erbb2 interacting protein 2 2
MIRT708237 PPP1R26 protein phosphatase 1 regulatory subunit 26 2 2
MIRT708629 NUDT18 nudix hydrolase 18 2 2
MIRT708990 CABP4 calcium binding protein 4 2 2
MIRT709804 FOXE1 forkhead box E1 2 2
MIRT710203 FLVCR1 feline leukemia virus subgroup C cellular receptor 1 2 2
MIRT710248 VAMP1 vesicle associated membrane protein 1 2 2
MIRT710281 FGF1 fibroblast growth factor 1 2 2
MIRT712992 IRGQ immunity related GTPase Q 2 2
MIRT713887 MOB3A MOB kinase activator 3A 2 2
MIRT715600 ADAM17 ADAM metallopeptidase domain 17 2 2
MIRT715639 ZBTB8B zinc finger and BTB domain containing 8B 2 2
MIRT715686 FRK fyn related Src family tyrosine kinase 2 2
MIRT717053 WIZ widely interspaced zinc finger motifs 2 2
MIRT717611 DSTYK dual serine/threonine and tyrosine protein kinase 2 2
MIRT721539 DKK3 dickkopf WNT signaling pathway inhibitor 3 2 2
MIRT722096 SUSD1 sushi domain containing 1 2 2
MIRT722435 HRNR hornerin 2 2
MIRT722855 NEGR1 neuronal growth regulator 1 2 2
MIRT724621 SNAP25 synaptosome associated protein 25 2 2
MIRT724777 PSG4 pregnancy specific beta-1-glycoprotein 4 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-6819 Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-miR-6819-3p Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-miR-6819-3p Cisplatin 5460033 NSC119875 approved resistant High Hypopharyngeal Cancer cell line (FaDu)
hsa-miR-6819-3p Gefitinib 123631 NSC715055 approved sensitive cell line (PC9)
hsa-miR-6819-3p Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-miR-6819-3p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-6819-3p Osimertinib 71496458 NSC779217 approved resistant cell line (H1975)
hsa-miR-6819-3p Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)

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