pre-miRNA Information
pre-miRNA hsa-mir-4763   
Genomic Coordinates chr22: 46113566 - 46113657
Description Homo sapiens miR-4763 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4763-5p
Sequence 19| CGCCUGCCCAGCCCUCCUGCU |39
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs374776264 1 dbSNP
rs1174502793 2 dbSNP
rs966122637 3 dbSNP
rs891363409 6 dbSNP
rs1303008773 8 dbSNP
rs1446379219 11 dbSNP
rs1410535134 13 dbSNP
rs1424733379 14 dbSNP
rs1372551711 16 dbSNP
rs756995936 17 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol NT5C   
Synonyms DNT, DNT1, HEL74, P5N2, PN-I, PN-II, UMPH2, cdN, dNT-1
Description 5', 3'-nucleotidase, cytosolic
Transcript NM_014595   
Expression
Putative miRNA Targets on NT5C
3'UTR of NT5C
(miRNA target sites are highlighted)
>NT5C|NM_014595|3'UTR
   1 GCGGGGATGCCGCGGGCAGCAGCTGGAGCTAAAGGAAGGGCAGGCCCACAGGGGCCACCGCAGAGCCGAGTCGGGGCGGC
  81 ATCGTGCTGGTGCCTCTGGCCCCGTGGAGTGGAGCAGGCAGATACCGTTAAGCGCTGTGCTACCGGGCCCCAGGCCCAGC
 161 CACCCGGTACCTCCCGAGAGGCTGTCCCTGGACCCTGGCTGGCATGGAAATACAGTGGGAAAACCAGTCGGGACCTTTAA
 241 TAAAAGACCTTGGCTTTCTAGTCAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' ucGUCCUC-----CCGACCCGUCCGc 5'
            | ||||     ||  |||||||| 
Target 5' agCTGGAGCTAAAGGAAGGGCAGGCc 3'
21 - 46 155.00 -25.90
2
miRNA  3' ucguCCUCCCGACC-CGUCCGc 5'
              ||||   ||| |||||| 
Target 5' ccgtGGAG---TGGAGCAGGCa 3'
102 - 120 126.00 -17.80
3
miRNA  3' ucgUCCUCC--CGACCCGUCcgc 5'
             :||| |  || ||||||   
Target 5' gcgGGGATGCCGC-GGGCAGcag 3'
1 - 22 115.00 -19.80
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30154705 6 COSMIC
COSN31535420 11 COSMIC
COSN15619117 14 COSMIC
COSN30700297 17 COSMIC
COSN30501163 39 COSMIC
COSN26987081 49 COSMIC
COSN30516248 68 COSMIC
COSN20072141 73 COSMIC
COSN30505097 77 COSMIC
COSN31504403 94 COSMIC
COSN31524251 102 COSMIC
COSN28759820 121 COSMIC
COSN28430258 147 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs755395128 1 dbSNP
rs751921314 2 dbSNP
rs766560480 3 dbSNP
rs375742971 4 dbSNP
rs1342894137 5 dbSNP
rs1316922303 6 dbSNP
rs372385448 9 dbSNP
rs371055235 11 dbSNP
rs760460909 12 dbSNP
rs754899584 13 dbSNP
rs964295416 13 dbSNP
rs896147757 14 dbSNP
rs751567104 17 dbSNP
rs775527324 17 dbSNP
rs1332783524 18 dbSNP
rs1479636804 19 dbSNP
rs141160505 25 dbSNP
rs1408850681 30 dbSNP
rs759352667 31 dbSNP
rs1476472153 38 dbSNP
rs781124421 46 dbSNP
rs774328015 47 dbSNP
rs770694360 48 dbSNP
rs374140608 49 dbSNP
rs1179490391 53 dbSNP
rs781161123 54 dbSNP
rs1163582210 60 dbSNP
rs566390357 61 dbSNP
rs1194489407 67 dbSNP
rs1418180044 68 dbSNP
rs1406704579 70 dbSNP
rs372648388 75 dbSNP
rs909114185 76 dbSNP
rs571263599 77 dbSNP
rs1004056975 80 dbSNP
rs929155966 83 dbSNP
rs551407531 89 dbSNP
rs1433100399 93 dbSNP
rs1293960732 94 dbSNP
rs531250771 95 dbSNP
rs568820287 98 dbSNP
rs548895134 102 dbSNP
rs111483112 103 dbSNP
rs1308463034 110 dbSNP
rs751466689 112 dbSNP
rs116149764 117 dbSNP
rs3752801 123 dbSNP
rs986147469 125 dbSNP
rs1436965991 126 dbSNP
rs1186648927 127 dbSNP
rs908385368 131 dbSNP
rs957634917 132 dbSNP
rs982528197 134 dbSNP
rs1201748699 135 dbSNP
rs1345305330 140 dbSNP
rs1410388344 149 dbSNP
rs1170236844 150 dbSNP
rs1373612273 157 dbSNP
rs1414059884 165 dbSNP
rs533104021 167 dbSNP
rs999083252 174 dbSNP
rs933738302 175 dbSNP
rs565285796 178 dbSNP
rs746872020 187 dbSNP
rs1428654993 204 dbSNP
rs1269835733 206 dbSNP
rs758146752 214 dbSNP
rs1278247823 215 dbSNP
rs975476098 216 dbSNP
rs963744385 220 dbSNP
rs189539553 234 dbSNP
rs1024440501 239 dbSNP
rs1212250215 245 dbSNP
rs1283013849 248 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HeLa
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in Chi_ControlB_2A8_130_50. RNA binding protein: AGO. Condition:HeLa cell Control B ...

- Chi SW; Zang JB; Mele A; Darnell RB, 2009, Nature.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' ucguccUCCCGACCCGUCCgc 5'
                | ||  |||||||  
Target 5' ----uaAAGGAAGGGCAGG-- 3'
1 - 15
Article - Chi SW; Zang JB; Mele A; Darnell RB
- Nature, 2009
MicroRNAs (miRNAs) have critical roles in the regulation of gene expression; however, as miRNA activity requires base pairing with only 6-8 nucleotides of messenger RNA, predicting target mRNAs is a major challenge. Recently, high-throughput sequencing of RNAs isolated by crosslinking immunoprecipitation (HITS-CLIP) has identified functional protein-RNA interaction sites. Here we use HITS-CLIP to covalently crosslink native argonaute (Ago, also called Eif2c) protein-RNA complexes in mouse brain. This produced two simultaneous data sets-Ago-miRNA and Ago-mRNA binding sites-that were combined with bioinformatic analysis to identify interaction sites between miRNA and target mRNA. We validated genome-wide interaction maps for miR-124, and generated additional maps for the 20 most abundant miRNAs present in P13 mouse brain. Ago HITS-CLIP provides a general platform for exploring the specificity and range of miRNA action in vivo, and identifies precise sequences for targeting clinically relevant miRNA-mRNA interactions.
LinkOut: [PMID: 19536157]
CLIP-seq Support 1 for dataset Chi_ControlB_2A8_130_50
Method / RBP HITS-CLIP / AGO
Cell line / Condition HeLa / HeLa cell Control B
Location of target site ENST00000582170.1 | 3UTR | UAAAGGAAGGGCAGG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 19536157 / Chi_HITSCLIP
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
69 hsa-miR-4763-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT116035 DEPDC1 DEP domain containing 1 2 2
MIRT347197 SIN3B SIN3 transcription regulator family member B 2 2
MIRT443248 C9orf170 chromosome 9 open reading frame 170 2 2
MIRT475164 IP6K1 inositol hexakisphosphate kinase 1 2 2
MIRT495486 VTI1B vesicle transport through interaction with t-SNAREs 1B 2 2
MIRT496755 TGIF2 TGFB induced factor homeobox 2 2 2
MIRT496863 C21orf2 chromosome 21 open reading frame 2 2 2
MIRT499264 NBPF11 NBPF member 11 2 2
MIRT499517 MAFK MAF bZIP transcription factor K 2 2
MIRT512952 MKI67 marker of proliferation Ki-67 2 2
MIRT514656 NUP93 nucleoporin 93 2 2
MIRT517986 SLC16A13 solute carrier family 16 member 13 2 2
MIRT522816 KLHL9 kelch like family member 9 2 4
MIRT525495 CD63 CD63 molecule 2 2
MIRT528111 FOXH1 forkhead box H1 2 2
MIRT531683 MYO3A myosin IIIA 2 2
MIRT534806 RAB37 RAB37, member RAS oncogene family 2 2
MIRT573041 SHMT1 serine hydroxymethyltransferase 1 2 2
MIRT576720 Wars tryptophanyl-tRNA synthetase 2 2
MIRT609727 MLXIPL MLX interacting protein like 2 2
MIRT610843 FAM180B family with sequence similarity 180 member B 2 4
MIRT614735 STAT5A signal transducer and activator of transcription 5A 2 2
MIRT616981 EPOR erythropoietin receptor 2 2
MIRT617265 MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 2 2
MIRT619405 INTS7 integrator complex subunit 7 2 2
MIRT621832 TIMM8A translocase of inner mitochondrial membrane 8A 2 2
MIRT621893 TAF13 TATA-box binding protein associated factor 13 2 2
MIRT630263 SMIM14 small integral membrane protein 14 2 2
MIRT634879 SENP8 SUMO/sentrin peptidase family member, NEDD8 specific 2 2
MIRT636863 ARSE arylsulfatase E (chondrodysplasia punctata 1) 2 2
MIRT637653 ADAT1 adenosine deaminase, tRNA specific 1 2 2
MIRT637699 ZNF439 zinc finger protein 439 2 2
MIRT637759 GATAD1 GATA zinc finger domain containing 1 2 2
MIRT638193 TAOK1 TAO kinase 1 2 2
MIRT638996 ADO 2-aminoethanethiol dioxygenase 2 2
MIRT642221 RABAC1 Rab acceptor 1 2 2
MIRT643327 ATCAY ATCAY, caytaxin 2 4
MIRT643419 ERVMER34-1 endogenous retrovirus group MER34 member 1, envelope 2 2
MIRT644499 RNF14 ring finger protein 14 2 2
MIRT644603 NT5DC3 5'-nucleotidase domain containing 3 2 2
MIRT644795 C21orf59 chromosome 21 open reading frame 59 2 2
MIRT648732 HIST1H2BD histone cluster 1 H2B family member d 2 2
MIRT653856 SHE Src homology 2 domain containing E 2 2
MIRT654129 RPL14 ribosomal protein L14 2 4
MIRT658876 DSN1 DSN1 homolog, MIS12 kinetochore complex component 2 2
MIRT671624 C20orf144 chromosome 20 open reading frame 144 2 4
MIRT677367 HSPA4L heat shock protein family A (Hsp70) member 4 like 2 2
MIRT677579 TRIM65 tripartite motif containing 65 2 2
MIRT678220 MACC1 MACC1, MET transcriptional regulator 2 2
MIRT679613 RRP36 ribosomal RNA processing 36 2 2
MIRT686081 PNPLA3 patatin like phospholipase domain containing 3 2 2
MIRT691817 ICA1L islet cell autoantigen 1 like 2 2
MIRT693869 COX19 COX19, cytochrome c oxidase assembly factor 2 2
MIRT694544 BPNT1 3'(2'), 5'-bisphosphate nucleotidase 1 2 2
MIRT694926 ANKS4B ankyrin repeat and sterile alpha motif domain containing 4B 2 2
MIRT697758 USP37 ubiquitin specific peptidase 37 2 2
MIRT697891 UBE2B ubiquitin conjugating enzyme E2 B 2 2
MIRT701569 MYPN myopalladin 2 2
MIRT703081 GPRIN3 GPRIN family member 3 2 2
MIRT708104 IGF2BP1 insulin like growth factor 2 mRNA binding protein 1 2 2
MIRT708320 NT5C 5', 3'-nucleotidase, cytosolic 2 2
MIRT709878 TRAF1 TNF receptor associated factor 1 2 2
MIRT713545 GJB1 gap junction protein beta 1 2 2
MIRT716275 NUP85 nucleoporin 85 2 2
MIRT716621 CRCP CGRP receptor component 2 2
MIRT717987 C9orf171 cilia and flagella associated protein 77 2 2
MIRT718438 RAB11B RAB11B, member RAS oncogene family 2 2
MIRT722544 AGPAT4 1-acylglycerol-3-phosphate O-acyltransferase 4 2 2
MIRT724013 F2RL1 F2R like trypsin receptor 1 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-4763 Cisplatin 5460033 NSC119875 approved sensitive High Gastric Cancer cell line (SGC7901)
hsa-mir-4763 Doxorubicin 31703 NSC123127 approved sensitive High Gastric Cancer cell line (SGC7901)
hsa-mir-4763 Fluorouracil 3385 NSC19893 approved sensitive High Gastric Cancer cell line (SGC7901)
hsa-mir-4763 Vincristine 5978 approved sensitive High Gastric Cancer cell line (SGC7901)
hsa-mir-4763 Dabrafenib 44462760 NSC764134 approved resistant cell line (A375)
hsa-mir-4763 Cisplatin 5460033 NSC119875 approved resistant cell line (BxPC3)
hsa-miR-4763-5p Anthracycline 30323 NSC82151 approved resistant High Breast Cancer tissue
hsa-miR-4763-5p Fluorouracil 3385 NSC19893 approved resistant High Breast Cancer tissue
hsa-miR-4763-5p Cyclophosphamide 2907 NSC26271 approved resistant High Breast Cancer tissue
hsa-miR-4763-5p Methotrexate 126941 NSC740 approved resistant High Breast Cancer tissue
hsa-miR-4763-5p Taxol 36314 NSC125973 approved resistant High Breast Cancer tissue
hsa-miR-4763-5p Temozolomide 5394 NSC362856 approved resistant cell line (U251)
hsa-miR-4763-5p Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-4763-5p Tamoxifen 2733525 NSC180973 approved sensitive cell line (LCC2)
hsa-miR-4763-5p Platinum 23939 sensitive tissue (non-small cell lung cancer)
hsa-miR-4763-5p Neoadjuvant chemotherapy resistant tissue (breast cancer)
hsa-miR-4763-5p Neoadjuvant chemotherapy resistant tissue (breast cancer)
hsa-miR-4763-5p Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (1500 ng/ml)

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