pre-miRNA Information
pre-miRNA hsa-mir-6819   
Genomic Coordinates chr22: 36286847 - 36286907
Description Homo sapiens miR-6819 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-6819-3p
Sequence 41| AAGCCUCUGUCCCCACCCCAG |61
Evidence Experimental
Experiments Meta-analysis
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1279530967 2 dbSNP
rs967579979 3 dbSNP
rs776891214 4 dbSNP
rs771166635 8 dbSNP
rs747037324 9 dbSNP
rs879248090 11 dbSNP
rs1485325191 12 dbSNP
rs778157316 16 dbSNP
Putative Targets

Gene Information
Gene Symbol NUDT18   
Synonyms MTH3
Description nudix hydrolase 18
Transcript NM_024815   
Expression
Putative miRNA Targets on NUDT18
3'UTR of NUDT18
(miRNA target sites are highlighted)
>NUDT18|NM_024815|3'UTR
   1 AGAGGTGGGGGAGGTGACAGGGAGCTAGGCAGCCGTGCTCCCTCCAGTGCGGACTTGTCTCCCTCTGAGGGAGGCAAGAG
  81 GCTGGCGATCAGGGATCTTGTTGCATTGGGAGCAGGGGCGGCTCTCCTGGTCCCCAGGAGAGATGCTTTGAGGAGCATTC
 161 CTCTAGATTGCACAAGGGACAGTGCCTTTAACCAAGCGAGGAGTCCAAAGCTCAGGACCTGACTACCCTGAGGGCACGCT
 241 GACGCCTCTTCCCAGGGGGATGGGGAGCTTTCTGCACCCCCAGTGGCATCTCCTCATCACGTTCTGTGCCGTCCTTGGGA
 321 AAGGCCTGCATTCTGATCCTTCCAGGCCCTTCGAGCATGGAGGGGCACTGGGGAAGGTCCCCCGAGGGAGGAGCACGTTG
 401 CTGAGTAAAGAGGTGTTACTCACCTTGC
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' gacccCACCC-CUG-UCUCCGAa 5'
               | ||| |:| ||||||| 
Target 5' cctctGAGGGAGGCAAGAGGCTg 3'
62 - 84 152.00 -21.10
2
miRNA  3' gaCCCCACCCCUGUCUC-CGAa 5'
            |||| || |||||:| ||| 
Target 5' tgGGGGAGGTGACAGGGAGCTa 3'
6 - 27 131.00 -26.40
3
miRNA  3' gaccccACCCCUGUCUCCGaa 5'
                |||| :|||:|||  
Target 5' ttgcatTGGGAGCAGGGGCgg 3'
101 - 121 127.00 -18.00
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN29964724 51 COSMIC
COSN31538122 85 COSMIC
COSN31573637 87 COSMIC
COSN30136875 116 COSMIC
COSN31550836 137 COSMIC
COSN28192284 262 COSMIC
COSN4878812 311 COSMIC
rs1552286 9 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1307300308 2 dbSNP
rs1316642355 3 dbSNP
rs778748323 4 dbSNP
rs781604205 5 dbSNP
rs1339070993 8 dbSNP
rs1552286 9 dbSNP
rs753173850 11 dbSNP
rs1372907010 12 dbSNP
rs767994135 13 dbSNP
rs755330886 16 dbSNP
rs973635200 17 dbSNP
rs1386007777 19 dbSNP
rs757629178 21 dbSNP
rs1471957695 22 dbSNP
rs752124043 24 dbSNP
rs1182193956 28 dbSNP
rs1483930052 29 dbSNP
rs1272300169 30 dbSNP
rs766752999 33 dbSNP
rs111541757 34 dbSNP
rs377397833 35 dbSNP
rs1039563514 36 dbSNP
rs1226226415 38 dbSNP
rs1378050905 43 dbSNP
rs1206306963 45 dbSNP
rs1279806199 46 dbSNP
rs1267026833 47 dbSNP
rs765500059 47 dbSNP
rs1196243101 49 dbSNP
rs373441540 50 dbSNP
rs1454311999 57 dbSNP
rs1489727154 61 dbSNP
rs912519821 64 dbSNP
rs1024236568 67 dbSNP
rs576123157 67 dbSNP
rs559502531 74 dbSNP
rs1168288067 75 dbSNP
rs559524766 77 dbSNP
rs1389677581 80 dbSNP
rs541363584 81 dbSNP
rs1385332503 84 dbSNP
rs1287544145 86 dbSNP
rs1014482352 87 dbSNP
rs929860998 89 dbSNP
rs1296131314 92 dbSNP
rs1344936852 94 dbSNP
rs769120299 106 dbSNP
rs1265248557 109 dbSNP
rs1354635014 111 dbSNP
rs892029312 112 dbSNP
rs1207746132 116 dbSNP
rs369822329 119 dbSNP
rs561349106 120 dbSNP
rs1245597001 121 dbSNP
rs904656327 122 dbSNP
rs1451270628 124 dbSNP
rs1193749018 126 dbSNP
rs1367711518 127 dbSNP
rs1038816231 129 dbSNP
rs376806678 132 dbSNP
rs1198080659 134 dbSNP
rs1456848238 136 dbSNP
rs76769824 138 dbSNP
rs557805207 142 dbSNP
rs1312589812 144 dbSNP
rs747545171 150 dbSNP
rs1247431120 154 dbSNP
rs1285663583 166 dbSNP
rs1335084972 188 dbSNP
rs1207650043 189 dbSNP
rs1265723682 197 dbSNP
rs11557549 198 dbSNP
rs987123229 200 dbSNP
rs929275786 201 dbSNP
rs961160260 208 dbSNP
rs1189367229 210 dbSNP
rs1418229844 211 dbSNP
rs539138670 215 dbSNP
rs919164768 216 dbSNP
rs1390973566 218 dbSNP
rs572305125 220 dbSNP
rs778765329 234 dbSNP
rs1454358360 236 dbSNP
rs1031138014 237 dbSNP
rs973304277 238 dbSNP
rs1286319672 239 dbSNP
rs554001567 243 dbSNP
rs1313885659 244 dbSNP
rs963549313 249 dbSNP
rs1005900 250 dbSNP
rs1255863422 257 dbSNP
rs904077423 260 dbSNP
rs1239129611 266 dbSNP
rs1022325207 280 dbSNP
rs1234584827 283 dbSNP
rs1482243047 284 dbSNP
rs1333399227 296 dbSNP
rs753748720 298 dbSNP
rs1482586622 300 dbSNP
rs900614346 301 dbSNP
rs1414453806 308 dbSNP
rs1341304685 310 dbSNP
rs1040857042 311 dbSNP
rs944769472 317 dbSNP
rs1432865119 319 dbSNP
rs1375944794 322 dbSNP
rs1468050101 323 dbSNP
rs890961449 325 dbSNP
rs1046851057 332 dbSNP
rs1173304449 340 dbSNP
rs766260418 346 dbSNP
rs970097383 352 dbSNP
rs1305869718 353 dbSNP
rs1375076388 353 dbSNP
rs1466462447 355 dbSNP
rs144206096 356 dbSNP
rs1014662103 360 dbSNP
rs919824139 361 dbSNP
rs1477391227 363 dbSNP
rs891757270 366 dbSNP
rs947701711 370 dbSNP
rs916374391 375 dbSNP
rs992321980 377 dbSNP
rs960454919 383 dbSNP
rs1032348804 384 dbSNP
rs192299592 387 dbSNP
rs1195417548 389 dbSNP
rs1000424477 391 dbSNP
rs1440397641 396 dbSNP
rs1213390704 397 dbSNP
rs537421605 405 dbSNP
rs904711320 407 dbSNP
rs1039204081 410 dbSNP
rs1467429634 412 dbSNP
rs1428308008 419 dbSNP
rs978233152 423 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HeLa
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in Chi_124A_2A8_130_50. RNA binding protein: AGO. Condition:HeLa cell miR-124 + A HITS-CLIP data was present in Chi_124B_2A8_130_50. RNA binding protein: AGO. Condition:HeLa cell miR-124 + B HITS-CLIP data was present in Chi_ControlB_2A8_130_50. RNA binding protein: AGO. Condition:HeLa cell Control B ...

- Chi SW; Zang JB; Mele A; Darnell RB, 2009, Nature.

Article - Chi SW; Zang JB; Mele A; Darnell RB
- Nature, 2009
MicroRNAs (miRNAs) have critical roles in the regulation of gene expression; however, as miRNA activity requires base pairing with only 6-8 nucleotides of messenger RNA, predicting target mRNAs is a major challenge. Recently, high-throughput sequencing of RNAs isolated by crosslinking immunoprecipitation (HITS-CLIP) has identified functional protein-RNA interaction sites. Here we use HITS-CLIP to covalently crosslink native argonaute (Ago, also called Eif2c) protein-RNA complexes in mouse brain. This produced two simultaneous data sets-Ago-miRNA and Ago-mRNA binding sites-that were combined with bioinformatic analysis to identify interaction sites between miRNA and target mRNA. We validated genome-wide interaction maps for miR-124, and generated additional maps for the 20 most abundant miRNAs present in P13 mouse brain. Ago HITS-CLIP provides a general platform for exploring the specificity and range of miRNA action in vivo, and identifies precise sequences for targeting clinically relevant miRNA-mRNA interactions.
LinkOut: [PMID: 19536157]
CLIP-seq Support 1 for dataset Chi_124A_2A8_130_50
Method / RBP HITS-CLIP / AGO
Cell line / Condition HeLa / HeLa cell miR-124 + A
Location of target site ENST00000522405.1 | 3UTR | GAGGGAGGCAAGAGGCUGGC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 19536157 / Chi_HITSCLIP
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset Chi_124B_2A8_130_50
Method / RBP HITS-CLIP / AGO
Cell line / Condition HeLa / HeLa cell miR-124 + B
Location of target site ENST00000522405.1 | 3UTR | GAGGGAGGCAAGAGGCUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 19536157 / Chi_HITSCLIP
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset Chi_ControlB_2A8_130_50
Method / RBP HITS-CLIP / AGO
Cell line / Condition HeLa / HeLa cell Control B
Location of target site ENST00000522405.1 | 3UTR | GAGGGAGGCAAGAGGC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 19536157 / Chi_HITSCLIP
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
108 hsa-miR-6819-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT358318 PANK3 pantothenate kinase 3 2 2
MIRT454719 UBQLNL ubiquilin like 2 2
MIRT471362 PEG10 paternally expressed 10 2 2
MIRT478101 DLG5 discs large MAGUK scaffold protein 5 2 4
MIRT495554 GOLGA6L4 golgin A6 family-like 4 2 2
MIRT495587 GOLGA6L10 golgin A6 family-like 10 2 2
MIRT508315 RPL18 ribosomal protein L18 2 4
MIRT529183 ADAM33 ADAM metallopeptidase domain 33 2 2
MIRT532035 FHDC1 FH2 domain containing 1 2 2
MIRT545131 ANXA5 annexin A5 2 2
MIRT567288 HNRNPL heterogeneous nuclear ribonucleoprotein L 2 2
MIRT568094 CEBPG CCAAT/enhancer binding protein gamma 2 2
MIRT573291 DLX4 distal-less homeobox 4 2 2
MIRT575169 Fam120c family with sequence similarity 120, member C 2 2
MIRT609495 DNASE1L3 deoxyribonuclease 1 like 3 2 2
MIRT611264 EHD3 EH domain containing 3 2 2
MIRT613580 POC5 POC5 centriolar protein 2 2
MIRT616520 C9orf170 chromosome 9 open reading frame 170 2 2
MIRT617098 ZNF667 zinc finger protein 667 2 2
MIRT618268 DDX51 DEAD-box helicase 51 2 2
MIRT618294 ZNF682 zinc finger protein 682 2 2
MIRT618617 SHOX short stature homeobox 2 2
MIRT619741 SRFBP1 serum response factor binding protein 1 2 2
MIRT619784 NRIP2 nuclear receptor interacting protein 2 2 2
MIRT621119 SP110 SP110 nuclear body protein 2 2
MIRT622530 RAD51 RAD51 recombinase 2 2
MIRT623088 NME6 NME/NM23 nucleoside diphosphate kinase 6 2 2
MIRT623938 FKBP14 FK506 binding protein 14 2 2
MIRT624389 CD84 CD84 molecule 2 2
MIRT624860 ABI2 abl interactor 2 2 2
MIRT628752 TRPV2 transient receptor potential cation channel subfamily V member 2 2 2
MIRT632243 VTA1 vesicle trafficking 1 2 2
MIRT632987 E2F2 E2F transcription factor 2 2 2
MIRT633695 RBM43 RNA binding motif protein 43 2 2
MIRT633766 CENPBD1 CENPB DNA-binding domain containing 1 2 2
MIRT633808 ZNF91 zinc finger protein 91 2 2
MIRT638914 CBLN2 cerebellin 2 precursor 2 2
MIRT641298 SLAMF1 signaling lymphocytic activation molecule family member 1 2 2
MIRT642123 SRCAP Snf2 related CREBBP activator protein 2 2
MIRT642179 HEBP2 heme binding protein 2 2 2
MIRT642617 CDKN3 cyclin dependent kinase inhibitor 3 2 2
MIRT643325 TMEM151B transmembrane protein 151B 2 2
MIRT644534 TMEM134 transmembrane protein 134 2 2
MIRT645820 OMA1 OMA1 zinc metallopeptidase 2 2
MIRT646093 MGST3 microsomal glutathione S-transferase 3 2 2
MIRT646861 SLC35E4 solute carrier family 35 member E4 2 2
MIRT647466 DZIP1L DAZ interacting zinc finger protein 1 like 2 2
MIRT647702 NADSYN1 NAD synthetase 1 2 2
MIRT648082 ZMIZ2 zinc finger MIZ-type containing 2 2 2
MIRT648547 TMEM169 transmembrane protein 169 2 2
MIRT648690 AP1M1 adaptor related protein complex 1 mu 1 subunit 2 2
MIRT649747 GNB5 G protein subunit beta 5 2 2
MIRT650154 ZNF426 zinc finger protein 426 2 2
MIRT650450 CPXM2 carboxypeptidase X, M14 family member 2 2 2
MIRT650943 CTNS cystinosin, lysosomal cystine transporter 2 2
MIRT651544 WNK1 WNK lysine deficient protein kinase 1 2 2
MIRT652304 TNRC6B trinucleotide repeat containing 6B 2 2
MIRT652890 SYVN1 synoviolin 1 2 2
MIRT654222 RNF19B ring finger protein 19B 2 2
MIRT654676 PSMB5 proteasome subunit beta 5 2 2
MIRT658249 FAXC failed axon connections homolog 2 2
MIRT658363 FAM65B RHO family interacting cell polarization regulator 2 2 2
MIRT659622 CELF1 CUGBP Elav-like family member 1 2 2
MIRT660171 BNIP3L BCL2 interacting protein 3 like 2 2
MIRT660634 ANKRD52 ankyrin repeat domain 52 2 2
MIRT662428 TMCO1 transmembrane and coiled-coil domains 1 2 2
MIRT662984 PAK3 p21 (RAC1) activated kinase 3 2 2
MIRT663939 ZNF554 zinc finger protein 554 2 2
MIRT666960 PKHD1 PKHD1, fibrocystin/polyductin 2 2
MIRT667945 HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 2 2
MIRT668847 CYCS cytochrome c, somatic 2 2
MIRT671792 RGS17 regulator of G protein signaling 17 2 2
MIRT672382 RPL37 ribosomal protein L37 2 2
MIRT673516 TNFAIP8L1 TNF alpha induced protein 8 like 1 2 4
MIRT674716 FAM73A mitoguardin 1 2 2
MIRT676352 KLF8 Kruppel like factor 8 2 2
MIRT677820 MRPS10 mitochondrial ribosomal protein S10 2 2
MIRT678440 PDE4C phosphodiesterase 4C 2 2
MIRT678499 ARHGEF39 Rho guanine nucleotide exchange factor 39 2 2
MIRT679243 LRP10 LDL receptor related protein 10 2 2
MIRT693607 SLC39A1 solute carrier family 39 member 1 2 2
MIRT695927 ZNF174 zinc finger protein 174 2 2
MIRT697987 TSPAN6 tetraspanin 6 2 2
MIRT700821 PHLDA2 pleckstrin homology like domain family A member 2 2 2
MIRT701350 NR4A3 nuclear receptor subfamily 4 group A member 3 2 2
MIRT702348 KLHL7 kelch like family member 7 2 2
MIRT703387 GABPB1 GA binding protein transcription factor beta subunit 1 2 2
MIRT703883 ERBB2IP erbb2 interacting protein 2 2
MIRT708237 PPP1R26 protein phosphatase 1 regulatory subunit 26 2 2
MIRT708629 NUDT18 nudix hydrolase 18 2 2
MIRT708990 CABP4 calcium binding protein 4 2 2
MIRT709804 FOXE1 forkhead box E1 2 2
MIRT710203 FLVCR1 feline leukemia virus subgroup C cellular receptor 1 2 2
MIRT710248 VAMP1 vesicle associated membrane protein 1 2 2
MIRT710281 FGF1 fibroblast growth factor 1 2 2
MIRT712992 IRGQ immunity related GTPase Q 2 2
MIRT713887 MOB3A MOB kinase activator 3A 2 2
MIRT715600 ADAM17 ADAM metallopeptidase domain 17 2 2
MIRT715639 ZBTB8B zinc finger and BTB domain containing 8B 2 2
MIRT715686 FRK fyn related Src family tyrosine kinase 2 2
MIRT717053 WIZ widely interspaced zinc finger motifs 2 2
MIRT717611 DSTYK dual serine/threonine and tyrosine protein kinase 2 2
MIRT721539 DKK3 dickkopf WNT signaling pathway inhibitor 3 2 2
MIRT722096 SUSD1 sushi domain containing 1 2 2
MIRT722435 HRNR hornerin 2 2
MIRT722855 NEGR1 neuronal growth regulator 1 2 2
MIRT724621 SNAP25 synaptosome associated protein 25 2 2
MIRT724777 PSG4 pregnancy specific beta-1-glycoprotein 4 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-6819 Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-miR-6819-3p Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-miR-6819-3p Cisplatin 5460033 NSC119875 approved resistant High Hypopharyngeal Cancer cell line (FaDu)
hsa-miR-6819-3p Gefitinib 123631 NSC715055 approved sensitive cell line (PC9)
hsa-miR-6819-3p Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-miR-6819-3p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-6819-3p Osimertinib 71496458 NSC779217 approved resistant cell line (H1975)
hsa-miR-6819-3p Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)

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