pre-miRNA Information | |
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pre-miRNA | hsa-mir-412 |
Genomic Coordinates | chr14: 101065447 - 101065537 |
Synonyms | MIRN412, hsa-mir-412, MIR412 |
Description | Homo sapiens miR-412 stem-loop |
Comment | None |
RNA Secondary Structure | ![]() |
Mature miRNA Information | ||||||||||||||||||||||||||||||||||||||||
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Mature miRNA | hsa-miR-412-3p | |||||||||||||||||||||||||||||||||||||||
Sequence | 54| ACUUCACCUGGUCCACUAGCCGU |76 | |||||||||||||||||||||||||||||||||||||||
Evidence | Not_experimental | |||||||||||||||||||||||||||||||||||||||
Experiments | DRVs in miRNA |
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SNPs in miRNA |
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Putative Targets |
miRNA Expression profile | |
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miRNAs in Extracellular Vesicles |
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Circulating MicroRNA Expression Profiling |
Gene Information | |||||||||||||||||||||
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Gene Symbol | TMSB4X | ||||||||||||||||||||
Synonyms | FX, PTMB4, TB4X, TMSB4 | ||||||||||||||||||||
Description | thymosin beta 4, X-linked | ||||||||||||||||||||
Transcript | NM_021109 | ||||||||||||||||||||
Expression | |||||||||||||||||||||
Putative miRNA Targets on TMSB4X | |||||||||||||||||||||
3'UTR of TMSB4X (miRNA target sites are highlighted) |
>TMSB4X|NM_021109|3'UTR 1 TGAGGCGTGCGCCGCCAATATGCACTGTACATTCCACAAGCATTGCCTTCTTATTTTACTTCTTTTAGCTGTTTAACTTT 81 GTAAGATGCAAAGAGGTTGGATCAAGTTTAAATGACTGTGCTGCCCCTTTCACATCAAAGAACTACTGACAACGAAGGCC 161 GCGCCTGCCTTTCCCATCTGTCTATCTATCTGGCTGGCAGGGAAGGAAAGAACTTGCATGTTGGTGAAGGAAGAAGTGGG 241 GTGGAAGAAGTGGGGTGGGACGACAGTGAAATCTAGAGTAAAACCAAGCTGGCCCAAGGTGTCCTGCAGGCTGTAATGCA 321 GTTTAATCAGAGTGCCATTTTTTTTTTTGTTCAAATGATTTTAATTATTGGAATGCACAATTTTTTTAATATGCAAATAA 401 AAAGTTTAAAAACTTAAAAAAAAAAAAAAAAAAAAAAAAAAAAA Target sites
Provided by authors
Predicted by miRanda
DRVs
SNPs
DRVs & SNPs
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miRNA-target interactions (Predicted by miRanda) |
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SNPs in gene 3'UTRs |
Experimental Support 1 for Functional miRNA-Target Interaction | |||||||
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miRNA:Target | ---- | ||||||
Validation Method |
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Conditions | HeLa | ||||||
Location of target site | 3'UTR | ||||||
Tools used in this research | TargetScan , miRTarCLIP , Piranha | ||||||
Original Description (Extracted from the article) |
...
HITS-CLIP data was present in Chi_ControlB_2A8_130_50. RNA binding protein: AGO. Condition:HeLa cell Control B
... - Chi SW; Zang JB; Mele A; Darnell RB, 2009, Nature. |
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miRNA-target interactions (Provided by authors) |
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Article |
- Chi SW; Zang JB; Mele A; Darnell RB - Nature, 2009
MicroRNAs (miRNAs) have critical roles in the regulation of gene expression; however, as miRNA activity requires base pairing with only 6-8 nucleotides of messenger RNA, predicting target mRNAs is a major challenge. Recently, high-throughput sequencing of RNAs isolated by crosslinking immunoprecipitation (HITS-CLIP) has identified functional protein-RNA interaction sites. Here we use HITS-CLIP to covalently crosslink native argonaute (Ago, also called Eif2c) protein-RNA complexes in mouse brain. This produced two simultaneous data sets-Ago-miRNA and Ago-mRNA binding sites-that were combined with bioinformatic analysis to identify interaction sites between miRNA and target mRNA. We validated genome-wide interaction maps for miR-124, and generated additional maps for the 20 most abundant miRNAs present in P13 mouse brain. Ago HITS-CLIP provides a general platform for exploring the specificity and range of miRNA action in vivo, and identifies precise sequences for targeting clinically relevant miRNA-mRNA interactions.
LinkOut: [PMID: 19536157]
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CLIP-seq Support 1 for dataset Chi_ControlB_2A8_130_50 | |
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Method / RBP | HITS-CLIP / AGO |
Cell line / Condition | HeLa / HeLa cell Control B |
Location of target site | ENST00000451311.2 | 3UTR | GAAGGAAAGAACUUGCAUGUUGGUGAAGGAAGAAGU |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 19536157 / Chi_HITSCLIP |
CLIP-seq Viewer | Link |
MiRNA-Target Expression Profile | |||||||
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MiRNA-Target Expression Profile (TCGA) | |||||||
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138 hsa-miR-412-3p Target Genes:
Functional analysis:
ID![]() |
Target | Description | Validation methods |
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Strong evidence | Less strong evidence | |||||||||||
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MIRT005780 | ACVR1C | activin A receptor type 1C | ![]() |
1 | 1 | |||||||
MIRT062013 | YOD1 | YOD1 deubiquitinase | ![]() |
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2 | 2 | ||||||
MIRT345112 | ATXN7L3 | ataxin 7 like 3 | ![]() |
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2 | 2 | ||||||
MIRT383735 | EDEM3 | ER degradation enhancing alpha-mannosidase like protein 3 | ![]() |
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2 | 2 | ||||||
MIRT396956 | CELF1 | CUGBP Elav-like family member 1 | ![]() |
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2 | 2 | ||||||
MIRT439280 | XIAP | X-linked inhibitor of apoptosis | ![]() |
1 | 1 | |||||||
MIRT439313 | VAT1 | vesicle amine transport 1 | ![]() |
1 | 1 | |||||||
MIRT439375 | TUBA1A | tubulin alpha 1a | ![]() |
1 | 1 | |||||||
MIRT439418 | TMOD1 | tropomodulin 1 | ![]() |
1 | 1 | |||||||
MIRT439503 | SURF4 | surfeit 4 | ![]() |
1 | 1 | |||||||
MIRT439563 | SON | SON DNA binding protein | ![]() |
1 | 1 | |||||||
MIRT439598 | SLC3A2 | solute carrier family 3 member 2 | ![]() |
1 | 1 | |||||||
MIRT439670 | SETD1B | SET domain containing 1B | ![]() |
1 | 1 | |||||||
MIRT439767 | RMND5A | required for meiotic nuclear division 5 homolog A | ![]() |
1 | 1 | |||||||
MIRT439922 | PPL | periplakin | ![]() |
1 | 1 | |||||||
MIRT439947 | PLEKHA6 | pleckstrin homology domain containing A6 | ![]() |
1 | 1 | |||||||
MIRT439952 | PLCB4 | phospholipase C beta 4 | ![]() |
1 | 1 | |||||||
MIRT439961 | PKD1 | polycystin 1, transient receptor potential channel interacting | ![]() |
1 | 1 | |||||||
MIRT440005 | PEG3 | paternally expressed 3 | ![]() |
1 | 1 | |||||||
MIRT440061 | OSBPL8 | oxysterol binding protein like 8 | ![]() |
1 | 1 | |||||||
MIRT440166 | MYH14 | myosin heavy chain 14 | ![]() |
1 | 1 | |||||||
MIRT440276 | MAPK8IP1 | mitogen-activated protein kinase 8 interacting protein 1 | ![]() |
1 | 1 | |||||||
MIRT440437 | IPO13 | importin 13 | ![]() |
1 | 1 | |||||||
MIRT440441 | INTS3 | integrator complex subunit 3 | ![]() |
1 | 1 | |||||||
MIRT440448 | INS | insulin | ![]() |
1 | 1 | |||||||
MIRT440461 | IGF2R | insulin like growth factor 2 receptor | ![]() |
1 | 1 | |||||||
MIRT440472 | IARS | isoleucyl-tRNA synthetase | ![]() |
1 | 1 | |||||||
MIRT440530 | GUCY1A3 | guanylate cyclase 1 soluble subunit alpha | ![]() |
1 | 1 | |||||||
MIRT440542 | GOLGA2 | golgin A2 | ![]() |
1 | 1 | |||||||
MIRT440569 | GIGYF1 | GRB10 interacting GYF protein 1 | ![]() |
1 | 1 | |||||||
MIRT440608 | FTSJD2 | cap methyltransferase 1 | ![]() |
1 | 1 | |||||||
MIRT440750 | EEF1A2 | eukaryotic translation elongation factor 1 alpha 2 | ![]() |
1 | 1 | |||||||
MIRT440781 | DOT1L | DOT1 like histone lysine methyltransferase | ![]() |
1 | 1 | |||||||
MIRT440804 | DNAJA4 | DnaJ heat shock protein family (Hsp40) member A4 | ![]() |
1 | 1 | |||||||
MIRT440867 | CSDE1 | cold shock domain containing E1 | ![]() |
1 | 1 | |||||||
MIRT440890 | CPEB4 | cytoplasmic polyadenylation element binding protein 4 | ![]() |
1 | 1 | |||||||
MIRT440917 | COL1A1 | collagen type I alpha 1 chain | ![]() |
1 | 1 | |||||||
MIRT440967 | CDH22 | cadherin 22 | ![]() |
1 | 1 | |||||||
MIRT440968 | CDH2 | cadherin 2 | ![]() |
1 | 1 | |||||||
MIRT441024 | CALR | calreticulin | ![]() |
1 | 1 | |||||||
MIRT441278 | ACTB | actin beta | ![]() |
1 | 1 | |||||||
MIRT448421 | TNFAIP3 | TNF alpha induced protein 3 | ![]() |
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2 | 2 | ||||||
MIRT462833 | BCL3 | B-cell CLL/lymphoma 3 | ![]() |
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2 | 2 | ||||||
MIRT465062 | TSR1 | TSR1, ribosome maturation factor | ![]() |
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2 | 2 | ||||||
MIRT476050 | GRSF1 | G-rich RNA sequence binding factor 1 | ![]() |
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2 | 2 | ||||||
MIRT485318 | MZT1 | mitotic spindle organizing protein 1 | ![]() |
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2 | 4 | ||||||
MIRT493584 | HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | ![]() |
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2 | 6 | ||||||
MIRT494567 | BAK1 | BCL2 antagonist/killer 1 | ![]() |
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2 | 2 | ||||||
MIRT497393 | RALY | RALY heterogeneous nuclear ribonucleoprotein | ![]() |
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2 | 2 | ||||||
MIRT503250 | ZNF257 | zinc finger protein 257 | ![]() |
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2 | 10 | ||||||
MIRT503656 | ZNF138 | zinc finger protein 138 | ![]() |
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2 | 10 | ||||||
MIRT505882 | RNF219 | ring finger protein 219 | ![]() |
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2 | 2 | ||||||
MIRT507525 | DSTN | destrin, actin depolymerizing factor | ![]() |
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2 | 4 | ||||||
MIRT510663 | TMBIM6 | transmembrane BAX inhibitor motif containing 6 | ![]() |
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2 | 4 | ||||||
MIRT514682 | ZNF701 | zinc finger protein 701 | ![]() |
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2 | 4 | ||||||
MIRT515370 | ZNF208 | zinc finger protein 208 | ![]() |
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2 | 6 | ||||||
MIRT525237 | KCNJ12 | potassium voltage-gated channel subfamily J member 12 | ![]() |
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2 | 2 | ||||||
MIRT527963 | MTAP | methylthioadenosine phosphorylase | ![]() |
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2 | 2 | ||||||
MIRT528482 | STAMBPL1 | STAM binding protein like 1 | ![]() |
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2 | 2 | ||||||
MIRT529909 | C1orf64 | steroid receptor associated and regulated protein | ![]() |
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2 | 4 | ||||||
MIRT531558 | SRD5A1 | steroid 5 alpha-reductase 1 | ![]() |
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2 | 2 | ||||||
MIRT532234 | KLF2 | Kruppel like factor 2 | ![]() |
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2 | 4 | ||||||
MIRT532480 | HOXA13 | homeobox A13 | ![]() |
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2 | 2 | ||||||
MIRT535544 | P2RY2 | purinergic receptor P2Y2 | ![]() |
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2 | 2 | ||||||
MIRT547311 | NR1D2 | nuclear receptor subfamily 1 group D member 2 | ![]() |
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2 | 2 | ||||||
MIRT551795 | ZNF117 | zinc finger protein 117 | ![]() |
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2 | 4 | ||||||
MIRT554939 | RAP1A | RAP1A, member of RAS oncogene family | ![]() |
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2 | 2 | ||||||
MIRT558171 | EIF5A2 | eukaryotic translation initiation factor 5A2 | ![]() |
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2 | 2 | ||||||
MIRT568771 | LY6K | lymphocyte antigen 6 family member K | ![]() |
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2 | 2 | ||||||
MIRT570766 | ZNF99 | zinc finger protein 99 | ![]() |
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2 | 2 | ||||||
MIRT572405 | MRPS14 | mitochondrial ribosomal protein S14 | ![]() |
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2 | 2 | ||||||
MIRT573396 | DLC1 | DLC1 Rho GTPase activating protein | ![]() |
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2 | 2 | ||||||
MIRT610403 | RXRB | retinoid X receptor beta | ![]() |
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2 | 2 | ||||||
MIRT610886 | SCN8A | sodium voltage-gated channel alpha subunit 8 | ![]() |
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2 | 2 | ||||||
MIRT611197 | TMEM105 | transmembrane protein 105 | ![]() |
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2 | 2 | ||||||
MIRT611244 | ZNF550 | zinc finger protein 550 | ![]() |
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2 | 2 | ||||||
MIRT615669 | LRIG2 | leucine rich repeats and immunoglobulin like domains 2 | ![]() |
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2 | 4 | ||||||
MIRT617974 | DOCK4 | dedicator of cytokinesis 4 | ![]() |
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2 | 2 | ||||||
MIRT619150 | ZNF326 | zinc finger protein 326 | ![]() |
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2 | 2 | ||||||
MIRT619608 | MKKS | McKusick-Kaufman syndrome | ![]() |
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2 | 2 | ||||||
MIRT621053 | DGKD | diacylglycerol kinase delta | ![]() |
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2 | 2 | ||||||
MIRT623665 | HRK | harakiri, BCL2 interacting protein | ![]() |
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2 | 2 | ||||||
MIRT624883 | AASDHPPT | aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase | ![]() |
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2 | 2 | ||||||
MIRT624939 | MARCH2 | membrane associated ring-CH-type finger 2 | ![]() |
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2 | 2 | ||||||
MIRT634198 | TMOD2 | tropomodulin 2 | ![]() |
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2 | 4 | ||||||
MIRT636727 | AGO2 | argonaute 2, RISC catalytic component | ![]() |
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2 | 2 | ||||||
MIRT637741 | POLR3K | RNA polymerase III subunit K | ![]() |
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2 | 2 | ||||||
MIRT638002 | ZC3H13 | zinc finger CCCH-type containing 13 | ![]() |
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2 | 2 | ||||||
MIRT640395 | ZNF785 | zinc finger protein 785 | ![]() |
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2 | 2 | ||||||
MIRT640505 | ANTXR1 | anthrax toxin receptor 1 | ![]() |
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2 | 2 | ||||||
MIRT641293 | SLAMF1 | signaling lymphocytic activation molecule family member 1 | ![]() |
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2 | 2 | ||||||
MIRT641863 | STOML1 | stomatin like 1 | ![]() |
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2 | 2 | ||||||
MIRT642600 | C14orf180 | chromosome 14 open reading frame 180 | ![]() |
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2 | 2 | ||||||
MIRT642895 | CASP1 | caspase 1 | ![]() |
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2 | 2 | ||||||
MIRT643967 | FHL2 | four and a half LIM domains 2 | ![]() |
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2 | 4 | ||||||
MIRT645237 | KCTD12 | potassium channel tetramerization domain containing 12 | ![]() |
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2 | 2 | ||||||
MIRT646621 | CENPL | centromere protein L | ![]() |
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2 | 2 | ||||||
MIRT648620 | CYB561A3 | cytochrome b561 family member A3 | ![]() |
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2 | 2 | ||||||
MIRT648908 | ZNF551 | zinc finger protein 551 | ![]() |
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2 | 2 | ||||||
MIRT649439 | HIBADH | 3-hydroxyisobutyrate dehydrogenase | ![]() |
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2 | 2 | ||||||
MIRT650637 | LTF | lactotransferrin | ![]() |
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2 | 2 | ||||||
MIRT650971 | STARD3NL | STARD3 N-terminal like | ![]() |
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2 | 2 | ||||||
MIRT651067 | ZNF518B | zinc finger protein 518B | ![]() |
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2 | 4 | ||||||
MIRT652384 | TMEM55A | phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2 | ![]() |
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2 | 2 | ||||||
MIRT653958 | SEPN1 | selenoprotein N | ![]() |
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2 | 2 | ||||||
MIRT656885 | KIF1C | kinesin family member 1C | ![]() |
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2 | 2 | ||||||
MIRT657965 | GAPVD1 | GTPase activating protein and VPS9 domains 1 | ![]() |
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2 | 2 | ||||||
MIRT658080 | FOXR2 | forkhead box R2 | ![]() |
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2 | 2 | ||||||
MIRT662570 | IL2RA | interleukin 2 receptor subunit alpha | ![]() |
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2 | 2 | ||||||
MIRT663089 | METTL10 | EEF1A lysine methyltransferase 2 | ![]() |
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2 | 2 | ||||||
MIRT683705 | ZNF195 | zinc finger protein 195 | ![]() |
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2 | 2 | ||||||
MIRT683835 | ZNF682 | zinc finger protein 682 | ![]() |
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2 | 2 | ||||||
MIRT706811 | APOL4 | apolipoprotein L4 | ![]() |
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2 | 2 | ||||||
MIRT707575 | DYNC2LI1 | dynein cytoplasmic 2 light intermediate chain 1 | ![]() |
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2 | 2 | ||||||
MIRT708606 | ZNF260 | zinc finger protein 260 | ![]() |
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2 | 2 | ||||||
MIRT708859 | TMSB4X | thymosin beta 4, X-linked | ![]() |
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2 | 2 | ||||||
MIRT709861 | PDIK1L | PDLIM1 interacting kinase 1 like | ![]() |
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2 | 2 | ||||||
MIRT709987 | RBM41 | RNA binding motif protein 41 | ![]() |
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2 | 2 | ||||||
MIRT710098 | KPNA5 | karyopherin subunit alpha 5 | ![]() |
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2 | 2 | ||||||
MIRT710211 | ENAH | ENAH, actin regulator | ![]() |
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2 | 2 | ||||||
MIRT710868 | B3GALNT1 | beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group) | ![]() |
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2 | 2 | ||||||
MIRT710986 | SUSD5 | sushi domain containing 5 | ![]() |
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2 | 2 | ||||||
MIRT711460 | RNF145 | ring finger protein 145 | ![]() |
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2 | 2 | ||||||
MIRT712302 | PGM2L1 | phosphoglucomutase 2 like 1 | ![]() |
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2 | 2 | ||||||
MIRT713609 | SYTL4 | synaptotagmin like 4 | ![]() |
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2 | 2 | ||||||
MIRT713789 | MAK16 | MAK16 homolog | ![]() |
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2 | 2 | ||||||
MIRT715480 | MYO9B | myosin IXB | ![]() |
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2 | 2 | ||||||
MIRT716328 | POU5F1 | POU class 5 homeobox 1 | ![]() |
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2 | 2 | ||||||
MIRT717252 | TMEM246 | transmembrane protein 246 | ![]() |
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2 | 2 | ||||||
MIRT718077 | CLIC5 | chloride intracellular channel 5 | ![]() |
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2 | 2 | ||||||
MIRT718463 | EED | embryonic ectoderm development | ![]() |
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2 | 2 | ||||||
MIRT718645 | NKPD1 | NTPase KAP family P-loop domain containing 1 | ![]() |
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2 | 2 | ||||||
MIRT718982 | PIGO | phosphatidylinositol glycan anchor biosynthesis class O | ![]() |
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2 | 2 | ||||||
MIRT721078 | RPS9 | ribosomal protein S9 | ![]() |
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2 | 2 | ||||||
MIRT721419 | SEC24A | SEC24 homolog A, COPII coat complex component | ![]() |
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2 | 2 | ||||||
MIRT721863 | CENPJ | centromere protein J | ![]() |
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2 | 2 | ||||||
MIRT722492 | PNKD | paroxysmal nonkinesigenic dyskinesia | ![]() |
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2 | 2 | ||||||
MIRT723391 | CALN1 | calneuron 1 | ![]() |
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2 | 2 |
miRNA-Drug Associations | |||||||||||||||||||||||||||
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miRNA-Drug Resistance Associations | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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