pre-miRNA Information
pre-miRNA hsa-mir-4457   
Genomic Coordinates chr5: 1309310 - 1309377
Description Homo sapiens miR-4457 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4457
Sequence 43| UCACAAGGUAUUGACUGGCGUA |64
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1031676297 8 dbSNP
rs1249861366 14 dbSNP
rs115769169 17 dbSNP
rs968846507 19 dbSNP
rs540870271 20 dbSNP
rs993130937 22 dbSNP
Putative Targets

Gene Information
Gene Symbol ZNF780A   
Synonyms ZNF780
Description zinc finger protein 780A
Transcript NM_001142579   
Other Transcripts NM_001142577 , NM_001142578 , NM_001010880   
Expression
Putative miRNA Targets on ZNF780A
3'UTR of ZNF780A
(miRNA target sites are highlighted)
>ZNF780A|NM_001142579|3'UTR
   1 ATGTAGGCGCTCAAATTTTGTTGCAAGATTTAATAGAGTGAAAACAGAGCTCCCATACAAAGGGAGGGGACCCAAAGAGG
  81 GTAGTCGTTGCCGGCTCGAATGCCTGGGTTTATATCCTGATCATTGTCCCTCCCGCTGTGCTCTCAGGCAATAGATGATT
 161 GGCTATTTCTTTACCTCCTGTTTTTGCCTAATTAGCATTTTAGCGGGCTCTCTTTCTTACCTGATGGGTCGGGTGTGAGC
 241 TGAGTTGCAAGCCCCGTGTTTAAAGGTGGATGTGGTCAACTTCCCATCTAGGCTTAGGGATTCTTAATCGGCCTAGGAAA
 321 TCCTGCTAGTCCTGTTTCTCAGTACCCCCTCTCAACAGGAAAACCCAAGTGCTGTTGGGGAGGTTGGCCAACAACTGCTC
 401 TAATTGCTTCCTGCTGAATTGGGGTGTAGTAGGGGTTGTGCAGTTGAGATTTCCTCTGGAGGGGTGCCTTCGATGTCATT
 481 AACATTGGAGCATGGGCTAGCAGGCCGGTCCAGGGGTCCGCGGTAGATTTTAGTCATGGACTGCATCTGGGGCTCCATTT
 561 GAAGAATGAGTTGTGGCTTTACAGCTTCGATTCTGGAAAAGACAAACTTAACAAGGAGGTTAAAGATACAGAGATTGAAA
 641 TGTATGGCCTGCAGTGCAGGGGATTATTTCTTTGGCACACTTCACAGGCCCTGACTATCTGCTTGATAGTTTTGAAAAGG
 721 CCTGGTCCATCTCCTCATTCTTAAAAAATGAGATTGAATTTTGATTAGCCCAGGAAAATTGTCTATGTGTTTAGATTTCT
 801 TTCTTTATAGTGTCATTTAGTGTTGTTCTCTTTGTTGCATATTCTGTACAAGGGAATTTGAGTCCAGAGGCTCTGTTAGG
 881 TCAGATTAAACATTTTGGGGAAGAATACTTTGTAGGCTATTTGTATGGCATATTTCACTGTCAGAAAACATTTAAGTACA
 961 GGTCCTTGCATTAGTGAAACTAAGTTTGATCATTTGGGTAAGCTGGTAACCGCCATAAGTCCATTGTAAAGATCTAATTT
1041 GTAGTGCATAAATAATCTATGGAGAGACTTTGACCTCTGAATATTTATAATCATGTGTATTTTAGCTGTGGATTGAATAC
1121 AAAATGAAAATTGAAATAGACTATTCAAAAATGAATGCCATTAAGGTTGTCAACATAAGTCAACTTGTGTGATAAGGCTG
1201 ACAGTATATTCAGTACAAAATTAGCACCCTCTAGTTTATTCAGGGAGCCAAGATTATTTTGTCTGGAACCTTGTTTTTGT
1281 TCAGCATTTATCATCAGCACCTATACATCATGGCTGGTATGTGAGCTGTTGATAAACTTTGAAAAAAATTAAGCCTTTAA
1361 ATCAAGCTATAAAACATGATACCATTGTGGCATCATGAATTAGAGAGATTAACTTTTTTAAAGATCAATAATAATCCTTT
1441 GTGATTTTATTCCAGTGCATTTAAAAATCTATAAAATGATAATTTATATTGATAGCTTTCTTCTTTTTGTGAATATATCC
1521 TTATCAGATTATTATGCTTTTGATAGACTACTTAATTCTATTTCTTAACATTTAATTGTATCTATAATCATAGGTAAAGT
1601 TATAATTTTCTAAACATTTTTCAGGTTTTGTTAATGCAGTGATCTTATAAATCTTACAAAACGAGGCTATTTAAAACCTG
1681 GCTTTCTAGTCTCATGTTCCTATTTTTTATTTCCACTTTCATCTTTTTCATATTGATTCTCTTTGACTTTCTTTTTTGAA
1761 CTCAACAGATTCCCTGGGTATTAACCCAGCACAACTCCTTTATGGGTCATTGCACATTCTGGTATCTCATTAAGAATTGT
1841 CATAAAAAAGAGATCCCAGGAGGCCTTCCAGTGAAACTCTATCATCATGCAATCTTGGGATTTCTAAGTTGGAAGTCACA
1921 GTCCCTTTGCAAACATAATAAAACACTTTAAAATATTTGCTAAAGTTACAAACCAATTATGTAAAAATTTAAAAATCACC
2001 TACTACTTTTAAAAGCAGAGAAGGCATCCATAGACTATTTCCTTGCTTACAAGCTCAGTGAACATACTGAATTCACTTAT
2081 AAAAAGAATTTTCTCAATTTTAGTTGCTTTTCAAAAAATTCTTATTCCTTTTATTTGTAATTCTTTGACATTGTTGCTGC
2161 TTCACAGTTTTGGTAATTGGACAGTTTGGTCTTTATTATGATATTAACATTTTTACCTGTCCTGAAACAAGGAAATACAA
2241 TCAAAGAAACAGAAGATTGGTGGACCTTGAACCACATTATGATATCAGATGACCCAGAGTCATGGTTACTAAGTTGCTTA
2321 AATTTTTAGTAACAAAGATGTATTAGAAAGTGACAGGTCAATTCAATAATGGTTTTTTTGGATACATTTAATTATATAAT
2401 CCCCTTAAGTTGTGCTTAGTCAGCAGTATTTAATCTGTTGTCTATTATATATCTAACTGGTCTGTTATGTTTATTATATA
2481 TTTATATATTGCTTATTCATATCTTATTGGAGTAACTCATTTTTAAAACAATATATTTCATCTCCTAGGAGAAGAGGATC
2561 GAGTATGTGTTTTTATTCTTTTTCATTAGGACATTGGGGTATTTTCTTATTGTGAAATGTATTGAATATTTCATTTATTT
2641 GGTTTGTGAGTCTGACCTTCACTCCCTAGCACTGATTTTTATTTGGCCCTCCTTTTACCTGATTCATAGGAGTTACGAGT
2721 AGCCGTTAATATGGATACATTTTTCCCATTTCTAGTACACTGCCCCTTCCAAAAGTGTCTGGCTTACTCAAACTTTTCTG
2801 TATTTGTTCCATCTTGCTTTTACAGATCAATACAAATAGGTAACTATACCTTCTAAACAAACATCAAGTTGGTGGAAAAA
2881 AGGCATATGAACAGTTCTTTCTCACCTACTATCAACAAACAGTAAATTAAACATTCCTAACTGCAGCCTCCTTTTGTAAA
2961 ATTTATAACCATTTATCTTTTGAGTGTGACATGATACTAGATGTATGATAATTACATGTTTTGTGTATCAGTATGAACAT
3041 GATTTTTAACAGACTTGTTCCAATGAACTATTATAGAGATGGTCCCCAACAATGTCAACTAACAATTTCTCAGCTTTATG
3121 ATGGTACAAAAGTGATATGTTGCTATAGTTTGGATATTTGTCCCTCCAAATCTCATGTTGAAGTTTGATCTCAGTGTTGG
3201 AGGTGGGGCCTAATGGAAGGTGTTTGGGTCATGGTGGAAGATCCCTCATGAATAAATTAATGCCCTCTCTGGATTGAGGG
3281 GTGAGTGAGCTATCGCTCTGTTAATTTTTGTGAGAGCTGGTTGTTCAAAAGAACCTGGCACCTCCTCCCTCACCCTCTTG
3361 TTTTCTCTCTTGCCATGTGATGTCTGCATACACTGGCTCTCCCTTCATCATCTGCCATGAGTGGAAGCAGCCTGAGACCC
3441 TTAGCAGAAGCAGATGCTGCACCATGATTCTTGTACATTCTGCAGAACAGTGAGCCAAATAAACCTCTTTATTAATCAAA
3521 AAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' augcGGUCA--GUUAUGGAACACu 5'
              :|| |  :||| |:||||| 
Target 5' aagaTCAATAATAATCCTTTGTGa 3'
1421 - 1444 140.00 -11.00
2
miRNA  3' auGCG-GUCAGUUAUGGAACACu 5'
            ||| | ||:||| ::||||| 
Target 5' atCGCTCTGTTAAT-TTTTGTGa 3'
3292 - 3313 135.00 -16.40
3
miRNA  3' augcggUCAGUUAUGGAACACu 5'
                ||||||   |||||| 
Target 5' aacataAGTCAA---CTTGTGt 3'
1172 - 1190 132.00 -12.50
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN31514588 8 COSMIC
COSN31535215 17 COSMIC
COSN16313784 161 COSMIC
COSN19590153 379 COSMIC
COSN1215587 589 COSMIC
COSN30151856 640 COSMIC
COSN27006554 644 COSMIC
COSN30481610 646 COSMIC
COSN13805472 659 COSMIC
COSN27006553 716 COSMIC
COSN30470843 743 COSMIC
COSN13805455 775 COSMIC
COSN30114875 776 COSMIC
COSN20192839 950 COSMIC
COSN27348694 1070 COSMIC
COSN5437983 1205 COSMIC
COSN17243391 1277 COSMIC
COSN6668679 1347 COSMIC
COSN31656676 1510 COSMIC
COSN17889311 1608 COSMIC
COSN26110978 1824 COSMIC
COSN229194 1831 COSMIC
COSN20881350 2021 COSMIC
COSN29323194 2085 COSMIC
COSN29794731 2111 COSMIC
COSN23277181 2476 COSMIC
COSN7126923 2833 COSMIC
COSN20831019 2894 COSMIC
COSN21368503 3180 COSMIC
COSN9357434 3187 COSMIC
COSN25112069 3285 COSMIC
COSN1215586 3477 COSMIC
COSN9226537 3535 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs561983765 7 dbSNP
rs139242176 8 dbSNP
rs1028748972 9 dbSNP
rs1255761997 10 dbSNP
rs1487789038 13 dbSNP
rs1224500705 23 dbSNP
rs915572093 25 dbSNP
rs1247585599 27 dbSNP
rs1203830370 38 dbSNP
rs202152059 39 dbSNP
rs1440683527 42 dbSNP
rs938562364 46 dbSNP
rs763003651 48 dbSNP
rs901590610 63 dbSNP
rs1191170051 71 dbSNP
rs1431795745 72 dbSNP
rs1470422214 83 dbSNP
rs775637790 91 dbSNP
rs1200804592 94 dbSNP
rs1315812159 96 dbSNP
rs977631045 98 dbSNP
rs184817914 104 dbSNP
rs1319586975 117 dbSNP
rs903792604 128 dbSNP
rs769931082 135 dbSNP
rs989522832 148 dbSNP
rs1347055131 158 dbSNP
rs958058299 163 dbSNP
rs1273019588 180 dbSNP
rs1439502772 181 dbSNP
rs1400473851 183 dbSNP
rs1332915414 186 dbSNP
rs1206316188 187 dbSNP
rs371958545 187 dbSNP
rs948087471 187 dbSNP
rs1214263949 189 dbSNP
rs12165115 189 dbSNP
rs997071343 191 dbSNP
rs1480914439 196 dbSNP
rs1353595738 203 dbSNP
rs1198994054 204 dbSNP
rs1305394415 204 dbSNP
rs1418379075 204 dbSNP
rs200980070 204 dbSNP
rs1170110554 205 dbSNP
rs1415419211 210 dbSNP
rs1427856353 218 dbSNP
rs532135379 225 dbSNP
rs1019787113 232 dbSNP
rs899708589 232 dbSNP
rs1240638668 235 dbSNP
rs1279630789 238 dbSNP
rs1349919206 242 dbSNP
rs1004748684 243 dbSNP
rs546441087 246 dbSNP
rs1490460889 256 dbSNP
rs1056468965 258 dbSNP
rs1265547331 264 dbSNP
rs1439761172 265 dbSNP
rs1182703847 271 dbSNP
rs1456578582 272 dbSNP
rs1363284766 273 dbSNP
rs575582337 274 dbSNP
rs918663842 279 dbSNP
rs1386336700 280 dbSNP
rs1424438166 282 dbSNP
rs972911663 284 dbSNP
rs539653259 285 dbSNP
rs1055446118 291 dbSNP
rs938626459 294 dbSNP
rs928509531 301 dbSNP
rs1276407388 304 dbSNP
rs977286312 314 dbSNP
rs962846157 319 dbSNP
rs945912306 321 dbSNP
rs192208816 322 dbSNP
rs989545359 330 dbSNP
rs1263449921 337 dbSNP
rs1341796646 342 dbSNP
rs1310746587 356 dbSNP
rs1196629491 363 dbSNP
rs773240022 376 dbSNP
rs958089632 381 dbSNP
rs1443947299 382 dbSNP
rs1456507517 385 dbSNP
rs1130277 391 dbSNP
rs187427476 392 dbSNP
rs1444559475 398 dbSNP
rs965658895 408 dbSNP
rs574978948 416 dbSNP
rs966215064 417 dbSNP
rs1462770546 418 dbSNP
rs1303130756 419 dbSNP
rs1443949404 420 dbSNP
rs1466874811 440 dbSNP
rs747949336 442 dbSNP
rs1395348836 443 dbSNP
rs1310431492 454 dbSNP
rs999318677 455 dbSNP
rs1172291076 456 dbSNP
rs1328016649 457 dbSNP
rs903663481 463 dbSNP
rs778485547 472 dbSNP
rs1004460582 473 dbSNP
rs1257684897 480 dbSNP
rs887302710 490 dbSNP
rs142626224 491 dbSNP
rs1012617424 496 dbSNP
rs895046894 497 dbSNP
rs1056899015 499 dbSNP
rs1180648154 500 dbSNP
rs1182728402 502 dbSNP
rs337783 511 dbSNP
rs938309526 512 dbSNP
rs897264200 516 dbSNP
rs142071381 523 dbSNP
rs941515764 532 dbSNP
rs557785205 533 dbSNP
rs1465076844 535 dbSNP
rs539706475 540 dbSNP
rs1354250720 543 dbSNP
rs1288097787 547 dbSNP
rs1237314211 551 dbSNP
rs1042062697 559 dbSNP
rs1277328214 564 dbSNP
rs779628697 565 dbSNP
rs755572641 568 dbSNP
rs1312949311 570 dbSNP
rs568789987 574 dbSNP
rs1376548305 576 dbSNP
rs914422738 577 dbSNP
rs1414554734 580 dbSNP
rs1486469962 581 dbSNP
rs1361666185 591 dbSNP
rs932919352 603 dbSNP
rs922865759 606 dbSNP
rs1054187446 617 dbSNP
rs1476662627 633 dbSNP
rs936764633 642 dbSNP
rs1222890699 643 dbSNP
rs1321101514 644 dbSNP
rs1165720107 647 dbSNP
rs976165549 650 dbSNP
rs943987599 651 dbSNP
rs1346961882 652 dbSNP
rs1425728799 655 dbSNP
rs1415992369 656 dbSNP
rs1287607107 658 dbSNP
rs965717176 659 dbSNP
rs1030716857 665 dbSNP
rs1217597973 668 dbSNP
rs1309228826 668 dbSNP
rs1265245835 674 dbSNP
rs761911169 677 dbSNP
rs977846519 687 dbSNP
rs965793121 690 dbSNP
rs912551138 693 dbSNP
rs149020307 694 dbSNP
rs1223615120 698 dbSNP
rs1246987439 699 dbSNP
rs1265466229 701 dbSNP
rs528817292 706 dbSNP
rs1012071299 707 dbSNP
rs567815675 708 dbSNP
rs987785204 709 dbSNP
rs1303520891 715 dbSNP
rs78392063 724 dbSNP
rs546257642 728 dbSNP
rs1374134023 730 dbSNP
rs572478702 735 dbSNP
rs1300015533 738 dbSNP
rs757669722 739 dbSNP
rs995642061 740 dbSNP
rs958448251 742 dbSNP
rs1034141862 743 dbSNP
rs149902159 744 dbSNP
rs1247261457 752 dbSNP
rs337782 754 dbSNP
rs1320798944 755 dbSNP
rs1392542243 757 dbSNP
rs1164570752 758 dbSNP
rs1478010291 761 dbSNP
rs1425570968 762 dbSNP
rs1218959721 766 dbSNP
rs1190787880 771 dbSNP
rs1457823924 772 dbSNP
rs1427810042 775 dbSNP
rs1267980307 776 dbSNP
rs1211046896 786 dbSNP
rs1010581285 792 dbSNP
rs542473660 792 dbSNP
rs1446366566 795 dbSNP
rs139352534 800 dbSNP
rs1272144472 802 dbSNP
rs34175173 821 dbSNP
rs1412769915 822 dbSNP
rs1403339198 824 dbSNP
rs1172816601 828 dbSNP
rs1355276985 830 dbSNP
rs1054218702 831 dbSNP
rs1198927198 843 dbSNP
rs931854655 845 dbSNP
rs1329392246 848 dbSNP
rs921760360 871 dbSNP
rs1037024065 877 dbSNP
rs941463264 882 dbSNP
rs1284076831 884 dbSNP
rs1377477877 886 dbSNP
rs1040222244 889 dbSNP
rs1319006039 891 dbSNP
rs944117828 895 dbSNP
rs1280432342 909 dbSNP
rs888514309 914 dbSNP
rs982774819 924 dbSNP
rs1050376402 950 dbSNP
rs1188190927 959 dbSNP
rs1236788055 963 dbSNP
rs1471697229 966 dbSNP
rs1326283158 972 dbSNP
rs868179994 992 dbSNP
rs1188033795 994 dbSNP
rs867949641 996 dbSNP
rs1302660765 1009 dbSNP
rs1388591309 1015 dbSNP
rs1368927820 1018 dbSNP
rs932806293 1026 dbSNP
rs1325450402 1034 dbSNP
rs922862691 1036 dbSNP
rs749814855 1039 dbSNP
rs1334092725 1051 dbSNP
rs1402769828 1057 dbSNP
rs764292123 1069 dbSNP
rs1433395963 1075 dbSNP
rs1271128864 1084 dbSNP
rs974321425 1094 dbSNP
rs77224922 1097 dbSNP
rs1275857174 1098 dbSNP
rs1325109402 1099 dbSNP
rs1034513192 1103 dbSNP
rs1003051759 1105 dbSNP
rs1440626023 1112 dbSNP
rs1378119743 1117 dbSNP
rs1217728208 1121 dbSNP
rs1200993750 1123 dbSNP
rs1477347072 1125 dbSNP
rs1452000124 1127 dbSNP
rs1191819470 1131 dbSNP
rs1251889113 1132 dbSNP
rs977709429 1137 dbSNP
rs1478403442 1139 dbSNP
rs971140243 1143 dbSNP
rs1020375570 1150 dbSNP
rs1009872947 1152 dbSNP
rs1299244198 1156 dbSNP
rs1360311892 1161 dbSNP
rs1458784440 1165 dbSNP
rs542254176 1194 dbSNP
rs967802724 1198 dbSNP
rs892798176 1199 dbSNP
rs183388669 1201 dbSNP
rs991080013 1202 dbSNP
rs1225419812 1210 dbSNP
rs553528493 1211 dbSNP
rs752808256 1213 dbSNP
rs146236625 1226 dbSNP
rs944138097 1241 dbSNP
rs1237212514 1246 dbSNP
rs1035355305 1247 dbSNP
rs891171014 1250 dbSNP
rs1047512462 1262 dbSNP
rs1471171886 1276 dbSNP
rs929993339 1277 dbSNP
rs919921102 1279 dbSNP
rs1369460254 1280 dbSNP
rs1302715464 1282 dbSNP
rs1165859117 1289 dbSNP
rs1408242300 1305 dbSNP
rs1392484156 1309 dbSNP
rs1447619628 1317 dbSNP
rs1379324454 1325 dbSNP
rs974342906 1330 dbSNP
rs1003495391 1344 dbSNP
rs961279748 1346 dbSNP
rs73549804 1347 dbSNP
rs1005542135 1352 dbSNP
rs927473549 1360 dbSNP
rs888545483 1361 dbSNP
rs1049811296 1362 dbSNP
rs1352878315 1386 dbSNP
rs1237769784 1391 dbSNP
rs997425142 1394 dbSNP
rs337781 1400 dbSNP
rs1357378055 1401 dbSNP
rs971564253 1407 dbSNP
rs539390487 1414 dbSNP
rs988519312 1418 dbSNP
rs957059535 1428 dbSNP
rs934938364 1429 dbSNP
rs1238175719 1438 dbSNP
rs1438352626 1440 dbSNP
rs1185865052 1443 dbSNP
rs1394432674 1447 dbSNP
rs924855050 1448 dbSNP
rs1457688408 1449 dbSNP
rs374913377 1450 dbSNP
rs773328461 1454 dbSNP
rs914979005 1457 dbSNP
rs1466787746 1460 dbSNP
rs1331429665 1462 dbSNP
rs996062695 1466 dbSNP
rs900403784 1475 dbSNP
rs1441012940 1484 dbSNP
rs1230818944 1487 dbSNP
rs1340878045 1490 dbSNP
rs1243708496 1493 dbSNP
rs990548899 1496 dbSNP
rs1019196797 1497 dbSNP
rs1008696641 1504 dbSNP
rs886261919 1507 dbSNP
rs569140055 1512 dbSNP
rs1456463856 1528 dbSNP
rs927856513 1536 dbSNP
rs1257401027 1543 dbSNP
rs1423613229 1550 dbSNP
rs930024328 1562 dbSNP
rs1366418543 1566 dbSNP
rs1478578939 1568 dbSNP
rs898524522 1583 dbSNP
rs375815503 1595 dbSNP
rs1038358534 1596 dbSNP
rs1398943995 1596 dbSNP
rs1346260342 1599 dbSNP
rs961312183 1610 dbSNP
rs1402750243 1612 dbSNP
rs937581059 1615 dbSNP
rs1240951212 1623 dbSNP
rs1219504369 1624 dbSNP
rs1342670310 1624 dbSNP
rs1277762812 1658 dbSNP
rs1316154016 1667 dbSNP
rs1205582089 1673 dbSNP
rs1257158892 1676 dbSNP
rs1015491301 1677 dbSNP
rs1483208127 1682 dbSNP
rs761578420 1685 dbSNP
rs1277971470 1693 dbSNP
rs143518536 1696 dbSNP
rs1488791535 1707 dbSNP
rs535100588 1711 dbSNP
rs1193969159 1721 dbSNP
rs780860537 1734 dbSNP
rs1422385719 1736 dbSNP
rs982095140 1738 dbSNP
rs1028734837 1754 dbSNP
rs1177585036 1767 dbSNP
rs1378173787 1771 dbSNP
rs950287007 1774 dbSNP
rs1238663119 1775 dbSNP
rs1300960287 1777 dbSNP
rs1362254741 1790 dbSNP
rs371215789 1799 dbSNP
rs192394140 1803 dbSNP
rs35828651 1809 dbSNP
rs1412701967 1812 dbSNP
rs774629733 1821 dbSNP
rs1221083348 1824 dbSNP
rs1302028824 1838 dbSNP
rs546322889 1849 dbSNP
rs998952951 1850 dbSNP
rs1288727536 1858 dbSNP
rs903466938 1859 dbSNP
rs1043251782 1862 dbSNP
rs946395049 1869 dbSNP
rs1405230171 1875 dbSNP
rs1032657480 1877 dbSNP
rs1487100918 1880 dbSNP
rs974340579 1886 dbSNP
rs1267470630 1887 dbSNP
rs1432052338 1889 dbSNP
rs914944855 1890 dbSNP
rs528151976 1893 dbSNP
rs1472899736 1896 dbSNP
rs538806784 1907 dbSNP
rs937797293 1908 dbSNP
rs1484930043 1917 dbSNP
rs189026426 1926 dbSNP
rs530973783 1943 dbSNP
rs1438845517 1953 dbSNP
rs961176975 1965 dbSNP
rs866154519 1972 dbSNP
rs564012147 1977 dbSNP
rs984003061 1982 dbSNP
rs994264266 1995 dbSNP
rs1223318902 2008 dbSNP
rs542513785 2009 dbSNP
rs1284296900 2015 dbSNP
rs1295360082 2031 dbSNP
rs337780 2035 dbSNP
rs1265596762 2037 dbSNP
rs1038388586 2042 dbSNP
rs1354629461 2046 dbSNP
rs1028349882 2049 dbSNP
rs1278744138 2067 dbSNP
rs1001571550 2068 dbSNP
rs1378272642 2069 dbSNP
rs1432754258 2075 dbSNP
rs1349456702 2079 dbSNP
rs905857422 2085 dbSNP
rs866762365 2086 dbSNP
rs965504661 2104 dbSNP
rs780436239 2125 dbSNP
rs1343400806 2131 dbSNP
rs1378342503 2133 dbSNP
rs1446727310 2140 dbSNP
rs1307661130 2142 dbSNP
rs1019635678 2144 dbSNP
rs998984174 2154 dbSNP
rs903328656 2160 dbSNP
rs76013928 2164 dbSNP
rs1011820671 2166 dbSNP
rs894699088 2186 dbSNP
rs533941340 2189 dbSNP
rs1054826482 2203 dbSNP
rs1392417490 2218 dbSNP
rs139983801 2228 dbSNP
rs1320744012 2237 dbSNP
rs577267048 2247 dbSNP
rs1162438264 2251 dbSNP
rs1457779744 2259 dbSNP
rs570762872 2261 dbSNP
rs78772583 2267 dbSNP
rs1473661770 2273 dbSNP
rs756762419 2280 dbSNP
rs575314535 2290 dbSNP
rs1046141400 2291 dbSNP
rs939842517 2301 dbSNP
rs911526994 2306 dbSNP
rs751094445 2311 dbSNP
rs987432135 2314 dbSNP
rs908415545 2322 dbSNP
rs79531788 2332 dbSNP
rs1449305580 2340 dbSNP
rs150576629 2340 dbSNP
rs983936426 2354 dbSNP
rs1231092931 2366 dbSNP
rs1279648584 2367 dbSNP
rs1318002969 2378 dbSNP
rs1217421650 2386 dbSNP
rs1026157609 2388 dbSNP
rs1444059126 2396 dbSNP
rs931276103 2404 dbSNP
rs1210607807 2415 dbSNP
rs1476651749 2426 dbSNP
rs921152918 2427 dbSNP
rs1484545200 2432 dbSNP
rs1215082657 2437 dbSNP
rs1424534436 2448 dbSNP
rs1477570454 2451 dbSNP
rs975459032 2452 dbSNP
rs1166229032 2455 dbSNP
rs1452311658 2456 dbSNP
rs1275276260 2457 dbSNP
rs965721673 2474 dbSNP
rs1334033416 2477 dbSNP
rs1357814371 2499 dbSNP
rs535347472 2500 dbSNP
rs11538334 2505 dbSNP
rs1299666348 2515 dbSNP
rs552544416 2516 dbSNP
rs963201620 2525 dbSNP
rs1398922459 2527 dbSNP
rs967430987 2537 dbSNP
rs1021769583 2540 dbSNP
rs1334473495 2544 dbSNP
rs1258428212 2556 dbSNP
rs1319189659 2563 dbSNP
rs1216115043 2566 dbSNP
rs1017071023 2567 dbSNP
rs1359708441 2571 dbSNP
rs1269585762 2579 dbSNP
rs1436569806 2587 dbSNP
rs1002008031 2589 dbSNP
rs141845621 2596 dbSNP
rs1323449904 2597 dbSNP
rs1460547828 2611 dbSNP
rs1478371654 2613 dbSNP
rs1400615002 2621 dbSNP
rs1393744532 2622 dbSNP
rs1421963871 2633 dbSNP
rs1159624735 2636 dbSNP
rs1171478723 2637 dbSNP
rs1046116599 2647 dbSNP
rs1315729023 2649 dbSNP
rs12972973 2652 dbSNP
rs1417973257 2654 dbSNP
rs894737977 2667 dbSNP
rs1436501702 2673 dbSNP
rs570537646 2678 dbSNP
rs758032584 2683 dbSNP
rs1274246416 2685 dbSNP
rs1368693122 2692 dbSNP
rs1034990785 2693 dbSNP
rs551940043 2694 dbSNP
rs1478385510 2699 dbSNP
rs182759968 2709 dbSNP
rs1352653685 2719 dbSNP
rs1203647328 2730 dbSNP
rs1292207791 2734 dbSNP
rs1191867218 2736 dbSNP
rs1468155111 2738 dbSNP
rs906164144 2739 dbSNP
rs570119021 2747 dbSNP
rs765149620 2748 dbSNP
rs939776765 2750 dbSNP
rs563571826 2754 dbSNP
rs530397989 2775 dbSNP
rs1048271928 2781 dbSNP
rs1179708382 2799 dbSNP
rs1380101095 2803 dbSNP
rs1038781548 2808 dbSNP
rs1156459872 2809 dbSNP
rs1392417528 2811 dbSNP
rs754770770 2822 dbSNP
rs1324602657 2823 dbSNP
rs1300575817 2828 dbSNP
rs911572980 2832 dbSNP
rs987516976 2838 dbSNP
rs1309842837 2844 dbSNP
rs921195890 2849 dbSNP
rs559833909 2854 dbSNP
rs1236534602 2861 dbSNP
rs1286230616 2870 dbSNP
rs1377103863 2878 dbSNP
rs1357312137 2882 dbSNP
rs1209358650 2883 dbSNP
rs1299583138 2894 dbSNP
rs1444805178 2895 dbSNP
rs1353160496 2903 dbSNP
rs753604193 2904 dbSNP
rs1238042226 2906 dbSNP
rs943963861 2911 dbSNP
rs543331657 2912 dbSNP
rs1397436127 2919 dbSNP
rs547819980 2924 dbSNP
rs1457697546 2925 dbSNP
rs963232290 2926 dbSNP
rs967463611 2938 dbSNP
rs1239019584 2943 dbSNP
rs1466675070 2947 dbSNP
rs879869777 2949 dbSNP
rs1479522054 2964 dbSNP
rs1389524407 2966 dbSNP
rs990351093 2967 dbSNP
rs1232040696 2968 dbSNP
rs959086926 2979 dbSNP
rs1335901670 2984 dbSNP
rs1210592791 3003 dbSNP
rs1033500209 3009 dbSNP
rs1291623484 3011 dbSNP
rs1001640566 3013 dbSNP
rs77641742 3016 dbSNP
rs1479927433 3017 dbSNP
rs1278117684 3023 dbSNP
rs565397594 3026 dbSNP
rs1232910183 3035 dbSNP
rs1202604399 3039 dbSNP
rs753834676 3053 dbSNP
rs543515001 3065 dbSNP
rs1014635929 3069 dbSNP
rs190946091 3072 dbSNP
rs1415132405 3088 dbSNP
rs1221670629 3092 dbSNP
rs1024675569 3095 dbSNP
rs766492561 3103 dbSNP
rs1031922277 3111 dbSNP
rs1372198348 3128 dbSNP
rs1460381854 3145 dbSNP
rs1174199527 3152 dbSNP
rs1297897546 3153 dbSNP
rs1000384518 3157 dbSNP
rs1415797818 3159 dbSNP
rs1342609440 3171 dbSNP
rs1400733308 3178 dbSNP
rs1003854479 3184 dbSNP
rs1305792209 3193 dbSNP
rs886876198 3212 dbSNP
rs148084708 3214 dbSNP
rs1364511401 3251 dbSNP
rs890170788 3252 dbSNP
rs1209155585 3254 dbSNP
rs1255039282 3256 dbSNP
rs34316409 3257 dbSNP
rs1193811590 3260 dbSNP
rs1417511635 3260 dbSNP
rs1407530655 3262 dbSNP
rs1260458490 3263 dbSNP
rs1426177501 3267 dbSNP
rs899700265 3283 dbSNP
rs1039538567 3285 dbSNP
rs918909461 3286 dbSNP
rs1362748045 3291 dbSNP
rs1420566405 3293 dbSNP
rs1476098011 3307 dbSNP
rs1359965114 3314 dbSNP
rs574380362 3319 dbSNP
rs1302652579 3320 dbSNP
rs1370898034 3339 dbSNP
rs1232602846 3341 dbSNP
rs368837433 3347 dbSNP
rs1354802335 3348 dbSNP
rs1041712202 3349 dbSNP
rs1259712085 3350 dbSNP
rs1210126398 3351 dbSNP
rs534616327 3370 dbSNP
rs926461561 3376 dbSNP
rs576736789 3382 dbSNP
rs980975388 3396 dbSNP
rs946025362 3401 dbSNP
rs1261932495 3413 dbSNP
rs970174730 3432 dbSNP
rs1024844351 3439 dbSNP
rs866646118 3444 dbSNP
rs1440008745 3447 dbSNP
rs1158678304 3454 dbSNP
rs992922183 3455 dbSNP
rs1459567555 3469 dbSNP
rs914661012 3469 dbSNP
rs1294152969 3475 dbSNP
rs144758917 3481 dbSNP
rs763115964 3482 dbSNP
rs186498946 3484 dbSNP
rs1234282886 3485 dbSNP
rs956063537 3488 dbSNP
rs1031617949 3497 dbSNP
rs1223517959 3504 dbSNP
rs1357805641 3506 dbSNP
rs1291957066 3510 dbSNP
rs774503838 3516 dbSNP
rs1414649746 3529 dbSNP
rs536734474 3530 dbSNP
rs990605228 3535 dbSNP
rs1290636410 3541 dbSNP
rs904757984 3552 dbSNP
rs1017772368 3554 dbSNP
rs1166010246 3580 dbSNP
rs958809717 3585 dbSNP
rs927492859 3595 dbSNP
rs1008176977 3604 dbSNP
rs890628727 3633 dbSNP
rs1051975692 3635 dbSNP
rs981620637 3640 dbSNP
rs971653128 3660 dbSNP
rs1415457952 3661 dbSNP
rs929027678 3664 dbSNP
rs1425755523 3668 dbSNP
rs1428980835 3668 dbSNP
rs1165685311 3671 dbSNP
rs570262439 3672 dbSNP
rs775782421 3685 dbSNP
rs1133156 3692 dbSNP
rs1459878177 3693 dbSNP
rs1333965309 3697 dbSNP
rs1003885561 3704 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HeLa
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in Chi_ControlB_2A8_130_50. RNA binding protein: AGO. Condition:HeLa cell Control B ...

- Chi SW; Zang JB; Mele A; Darnell RB, 2009, Nature.

Article - Chi SW; Zang JB; Mele A; Darnell RB
- Nature, 2009
MicroRNAs (miRNAs) have critical roles in the regulation of gene expression; however, as miRNA activity requires base pairing with only 6-8 nucleotides of messenger RNA, predicting target mRNAs is a major challenge. Recently, high-throughput sequencing of RNAs isolated by crosslinking immunoprecipitation (HITS-CLIP) has identified functional protein-RNA interaction sites. Here we use HITS-CLIP to covalently crosslink native argonaute (Ago, also called Eif2c) protein-RNA complexes in mouse brain. This produced two simultaneous data sets-Ago-miRNA and Ago-mRNA binding sites-that were combined with bioinformatic analysis to identify interaction sites between miRNA and target mRNA. We validated genome-wide interaction maps for miR-124, and generated additional maps for the 20 most abundant miRNAs present in P13 mouse brain. Ago HITS-CLIP provides a general platform for exploring the specificity and range of miRNA action in vivo, and identifies precise sequences for targeting clinically relevant miRNA-mRNA interactions.
LinkOut: [PMID: 19536157]
CLIP-seq Support 1 for dataset Chi_ControlB_2A8_130_50
Method / RBP HITS-CLIP / AGO
Cell line / Condition HeLa / HeLa cell Control B
Location of target site ENST00000450241.2 | 3UTR | GUGAGAAAGUCUUUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 19536157 / Chi_HITSCLIP
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
83 hsa-miR-4457 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT098032 SOBP sine oculis binding protein homolog 2 2
MIRT202580 PCMTD2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2 2 6
MIRT247137 WEE1 WEE1 G2 checkpoint kinase 2 4
MIRT349266 PTBP1 polypyrimidine tract binding protein 1 2 2
MIRT363756 EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 2 2
MIRT443586 FAM84B family with sequence similarity 84 member B 2 2
MIRT452333 EIF5AL1 eukaryotic translation initiation factor 5A-like 1 2 2
MIRT453864 ZBTB40 zinc finger and BTB domain containing 40 2 4
MIRT471486 PDE4D phosphodiesterase 4D 2 4
MIRT476290 GMFB glia maturation factor beta 2 8
MIRT479897 CCDC117 coiled-coil domain containing 117 2 4
MIRT484251 ANK1 ankyrin 1 2 2
MIRT491473 TMEM214 transmembrane protein 214 2 2
MIRT493804 GAN gigaxonin 2 6
MIRT499252 VAV3 vav guanine nucleotide exchange factor 3 2 4
MIRT502271 HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 2 4
MIRT504651 RPL9 ribosomal protein L9 2 6
MIRT505211 UBN2 ubinuclein 2 2 8
MIRT508952 SNRPB small nuclear ribonucleoprotein polypeptides B and B1 2 4
MIRT512691 POP1 POP1 homolog, ribonuclease P/MRP subunit 2 2
MIRT513320 SCUBE3 signal peptide, CUB domain and EGF like domain containing 3 2 2
MIRT513870 HOXA5 homeobox A5 2 2
MIRT517342 ZNF529 zinc finger protein 529 2 4
MIRT518947 LSG1 large 60S subunit nuclear export GTPase 1 2 2
MIRT520867 SUGT1 SGT1 homolog, MIS12 kinetochore complex assembly cochaperone 2 2
MIRT528325 GIGYF2 GRB10 interacting GYF protein 2 2 2
MIRT531990 SLCO1B3 solute carrier organic anion transporter family member 1B3 2 2
MIRT533298 USP46 ubiquitin specific peptidase 46 2 2
MIRT545257 TRIM36 tripartite motif containing 36 2 4
MIRT547038 POGZ pogo transposable element derived with ZNF domain 2 2
MIRT556103 MOAP1 modulator of apoptosis 1 2 2
MIRT558321 DR1 down-regulator of transcription 1 2 2
MIRT558521 CSRNP3 cysteine and serine rich nuclear protein 3 2 2
MIRT560906 TMED10 transmembrane p24 trafficking protein 10 2 2
MIRT568448 ARPP19 cAMP regulated phosphoprotein 19 2 2
MIRT570586 OTUD7B OTU deubiquitinase 7B 2 2
MIRT572799 SIGLEC14 sialic acid binding Ig like lectin 14 2 2
MIRT573863 C9orf78 chromosome 9 open reading frame 78 2 2
MIRT575058 P2ry1 purinergic receptor P2Y, G-protein coupled 1 2 5
MIRT609931 SLC38A1 solute carrier family 38 member 1 2 4
MIRT610836 ZNF585A zinc finger protein 585A 2 4
MIRT611474 P2RY1 purinergic receptor P2Y1 2 7
MIRT613569 YY2 YY2 transcription factor 2 2
MIRT618626 GREB1 growth regulation by estrogen in breast cancer 1 2 2
MIRT620606 SAP30 Sin3A associated protein 30 2 2
MIRT621017 CLSTN3 calsyntenin 3 2 4
MIRT635314 FAM179A TOG array regulator of axonemal microtubules 2 2 2
MIRT635919 GLTSCR2 NOP53 ribosome biogenesis factor 2 2
MIRT640598 TM9SF4 transmembrane 9 superfamily member 4 2 2
MIRT641784 YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta 2 4
MIRT644067 IQCE IQ motif containing E 2 2
MIRT648288 TRAPPC2L trafficking protein particle complex 2 like 2 2
MIRT658085 FOXR2 forkhead box R2 2 2
MIRT659077 DEPTOR DEP domain containing MTOR interacting protein 2 2
MIRT665307 ZBTB37 zinc finger and BTB domain containing 37 2 2
MIRT665975 SYTL4 synaptotagmin like 4 2 2
MIRT666302 SLC25A25 solute carrier family 25 member 25 2 2
MIRT674906 RASSF9 Ras association domain family member 9 2 2
MIRT680086 THAP1 THAP domain containing 1 2 2
MIRT681488 DIP2A disco interacting protein 2 homolog A 2 2
MIRT691244 DFNB59 pejvakin 2 2
MIRT692362 AGTRAP angiotensin II receptor associated protein 2 2
MIRT693035 MB21D1 Mab-21 domain containing 1 2 2
MIRT693837 STAT5A signal transducer and activator of transcription 5A 2 2
MIRT694479 LRTOMT leucine rich transmembrane and O-methyltransferase domain containing 2 2
MIRT696070 ZNF264 zinc finger protein 264 2 2
MIRT696578 TTC21B tetratricopeptide repeat domain 21B 2 2
MIRT696760 MTFMT mitochondrial methionyl-tRNA formyltransferase 2 2
MIRT697307 ZNF652 zinc finger protein 652 2 2
MIRT700152 RNF115 ring finger protein 115 2 2
MIRT701056 PARP2 poly(ADP-ribose) polymerase 2 2 2
MIRT701198 OTUD3 OTU deubiquitinase 3 2 2
MIRT701335 NSD1 nuclear receptor binding SET domain protein 1 2 2
MIRT702656 ITGA3 integrin subunit alpha 3 2 2
MIRT703618 FBXO45 F-box protein 45 2 2
MIRT704673 CHTOP chromatin target of PRMT1 2 2
MIRT708894 ZNF780A zinc finger protein 780A 2 2
MIRT711620 DGKH diacylglycerol kinase eta 2 2
MIRT713745 TMEM81 transmembrane protein 81 2 2
MIRT719712 CD101 CD101 molecule 2 2
MIRT720294 DLGAP3 DLG associated protein 3 2 2
MIRT722606 CCDC152 coiled-coil domain containing 152 2 2
MIRT724566 ACSBG1 acyl-CoA synthetase bubblegum family member 1 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-4457 Dabrafenib 44462760 NSC764134 approved sensitive cell line (A375)
hsa-miR-4457 Gefitinib 123631 NSC715055 approved sensitive cell line (PC9)
hsa-miR-4457 Osimertinib 71496458 NSC779217 approved sensitive cell line (PC9)
hsa-miR-4457 Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)

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