pre-miRNA Information
pre-miRNA hsa-mir-4749   
Genomic Coordinates chr19: 49854591 - 49854651
Description Homo sapiens miR-4749 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4749-3p
Sequence 42| CGCCCCUCCUGCCCCCACAG |61
Evidence Experimental
Experiments Illumina
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN19730808 2 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs147943327 1 dbSNP
rs148982635 2 dbSNP
rs372882504 3 dbSNP
rs200056596 4 dbSNP
rs570340094 5 dbSNP
rs778438436 11 dbSNP
rs748573000 13 dbSNP
rs770230641 14 dbSNP
rs201103722 16 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol MGAT5B   
Synonyms GnT-IX, GnT-VB
Description mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B
Transcript NM_144677   
Other Transcripts NM_198955   
Expression
Putative miRNA Targets on MGAT5B
3'UTR of MGAT5B
(miRNA target sites are highlighted)
>MGAT5B|NM_144677|3'UTR
   1 ATCCGCCTCTGCCGCCCTGCCTGGCACCCACGCTGGCTCTCTCCTGCCGCGGGAGAAAGCACCAGCAGGTTCTGAGCCCT
  81 GGCTGCTTGTCCTCCTCGCAACCCCCCCAGGCCGGAGCTTCCTTCCTTAGCCGGGAAGCTGGCAGAGGAGAGCCGTGCCC
 161 GGGAATAGGAGGAGGCAGCATGCCGAGCCCCTGGGACCTCCCAGGCAGGCTCCGGTTCTCTCCTGGGGACTCACAGAAGC
 241 ATCGTGGCCAAGCAGGTGTCGGACTGCTCAGAGTCCGCATGGCCCAGGAGCAGGTGGTCGGAGGCCCCTGGCTTTGTGCA
 321 AGGCCGGATCTGGGCCAGGTGGCGAAAGGGGCCCAGTCGTTCTTGGGCCCAGGATGGGGCCTCTAGACTTGCAAGGGAGA
 401 GGAACAGGGACCAGGCTGCCCCACGGTCCCTGAAGGGTCCAAGGAGGGGCCCTCCCCATGGCCCTGGAGAGTGGGCCTGG
 481 GTGGTACCTGCTCCAGGCAGGGAAACTGGGGGCTCGCCCTTCTCCTGTGAGGGGAGCCAGGCACACAGGGCCCATTGGTG
 561 TTTGGGATGTGGACAGAGGGGCAGGGGGCTGGGAGAAGGCTAAGCCGAGGGGTCCTGTTTGTGCCTCCCCTTAGTCCCTT
 641 CCCTCCCGATTTCCCGATTCCCCCACCCTCCCTCTACACTTGAGGACCACAGTTGGGGGTGTAGGGACCACCCAGACCCT
 721 GGTTGAATTGTTTCTCTCTCCTGCTTGTTCCAACCCTTTTCACTCTGGGCTTCTCCCAAAACCCATCCTGGCATGACCTG
 801 CAACTCCAGGTGGTGGATTTGTTCCAAAGCCTCAATCCCTACCCCCTCCAAGGGGCAGGTTTCCAGTCCAGCCTCAGAGA
 881 TCAGGCTCTGGGACCCCTGCCTGGGGGGTGGCCTTCATGCACTAGCCACTTCCGCAGGTGCTGACTCCCGCACTCCCTGG
 961 CATTTTTTGCAGACAAGGGCTTGGGATGGACCCTCAGCCCCATGGTACGCCCTGCCCAGTTTCCAGTTGCCCTGTCCACT
1041 TACCCTAGGTAGCCCCCCACCCCATCAGTGCCGAGTCCTTGTCCCTACCTCCAGCTTCCTCCAGCCTCAAACCGCCTCTG
1121 GATCTAGCTGTCCTTCTCCGAGTGGCACGCCTGCCCCAGGATGCCCCCTTTCCCTCCCCCCCATGCCCAGAGCCCCGCCT
1201 GCCTCAGCGGGTCAGGCCTTCAGAACACTGCCACCCACCCAGTTTTATAATCCCGCTCCCTCTCCAGGCAACCCCACCCA
1281 CCAGCCTAGGCCTGCTCCTCCACCCTTCCCGGGAGGCAGCCCCGGGATGCTGAGAGTTGGTGGAGGGGCCAGGCTGGACG
1361 CTTCCTGTGGGAGTCCCCTCCAGACCTGGCTGGCCCCTGCAGCCACAGAAACCACGATGGCAAAAAATCTCATTGGTTCT
1441 CAAGGACTAACCTGTGGGGGAAAGCAATAGAGACACTCTTTTTCTCTCTTTTTTTTAAAGATTTATTTCTTGAAATAATA
1521 AATATTTTATTGGGATGTGAGGTGCAGAAGAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' gacacCCCCG--UCCUCCCCGc 5'
               ||| |  ||||||||| 
Target 5' ctgaaGGGTCCAAGGAGGGGCc 3'
430 - 451 157.00 -24.30
2
miRNA  3' gacACCCCCGUCCUCCCCGc 5'
             || || || ||||||| 
Target 5' ggaTGTGGACA-GAGGGGCa 3'
565 - 583 156.00 -20.00
3
miRNA  3' gaCACCCCCGUCCUCCCCGc 5'
            | |  ||: |||||||| 
Target 5' gaGAGTTGGT-GGAGGGGCc 3'
1332 - 1350 149.00 -18.70
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN31995766 3 COSMIC
COSN31995767 4 COSMIC
COSN28759039 10 COSMIC
COSN28796366 15 COSMIC
COSN19736548 20 COSMIC
COSN30119267 29 COSMIC
COSN30162442 40 COSMIC
COSN31604862 56 COSMIC
COSN27561505 105 COSMIC
COSN31582401 118 COSMIC
COSN1201596 143 COSMIC
COSN31480238 149 COSMIC
COSN6660935 236 COSMIC
COSN16810554 326 COSMIC
COSN22574036 337 COSMIC
COSN1201597 517 COSMIC
COSN1201598 518 COSMIC
COSN28986541 1012 COSMIC
COSN28696528 1059 COSMIC
COSN23506032 1114 COSMIC
COSN26645062 1174 COSMIC
COSN31584004 1183 COSMIC
COSN14598456 1190 COSMIC
COSN6549356 1237 COSMIC
COSN28799706 1367 COSMIC
COSN30539250 1416 COSMIC
COSN28690224 1434 COSMIC
COSN1201599 1497 COSMIC
COSN20114477 1497 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs369927562 4 dbSNP
rs373384799 5 dbSNP
rs376365445 6 dbSNP
rs750934257 14 dbSNP
rs1377533700 15 dbSNP
rs3803745 15 dbSNP
rs1433787489 16 dbSNP
rs1158128345 21 dbSNP
rs780164982 22 dbSNP
rs1421816830 23 dbSNP
rs558944250 32 dbSNP
rs374995896 33 dbSNP
rs1188097430 36 dbSNP
rs1435541347 37 dbSNP
rs748006684 41 dbSNP
rs769520233 42 dbSNP
rs948111935 48 dbSNP
rs200474167 49 dbSNP
rs917904721 50 dbSNP
rs370707961 51 dbSNP
rs749244206 52 dbSNP
rs373772029 53 dbSNP
rs1348253463 57 dbSNP
rs903112418 60 dbSNP
rs748019010 64 dbSNP
rs1366895588 66 dbSNP
rs535084596 73 dbSNP
rs1047567904 76 dbSNP
rs999998540 78 dbSNP
rs1054687094 92 dbSNP
rs771901426 93 dbSNP
rs1367726461 95 dbSNP
rs1007702898 98 dbSNP
rs117203281 99 dbSNP
rs1168342898 100 dbSNP
rs1448099332 101 dbSNP
rs1194209214 102 dbSNP
rs1250099882 102 dbSNP
rs965671166 103 dbSNP
rs777667238 104 dbSNP
rs199841923 105 dbSNP
rs375337411 108 dbSNP
rs568652431 109 dbSNP
rs577422196 110 dbSNP
rs952390076 114 dbSNP
rs900155062 115 dbSNP
rs1396168741 117 dbSNP
rs1376570489 118 dbSNP
rs1386429429 125 dbSNP
rs1308005967 132 dbSNP
rs985100748 133 dbSNP
rs545419773 134 dbSNP
rs558891303 135 dbSNP
rs967839389 153 dbSNP
rs959598547 155 dbSNP
rs992175770 156 dbSNP
rs1286760707 162 dbSNP
rs960901704 167 dbSNP
rs992401030 167 dbSNP
rs918019839 170 dbSNP
rs1202970290 176 dbSNP
rs1229179293 182 dbSNP
rs916866279 184 dbSNP
rs879770437 185 dbSNP
rs945341717 186 dbSNP
rs1353810029 188 dbSNP
rs974118864 191 dbSNP
rs1233330828 196 dbSNP
rs1349372581 199 dbSNP
rs139194011 201 dbSNP
rs371446695 201 dbSNP
rs1408553452 204 dbSNP
rs180843440 206 dbSNP
rs930069050 210 dbSNP
rs186722572 211 dbSNP
rs935913592 213 dbSNP
rs775814677 214 dbSNP
rs763130120 215 dbSNP
rs1411352420 219 dbSNP
rs1473530691 221 dbSNP
rs1233447471 224 dbSNP
rs888932334 229 dbSNP
rs1464084889 233 dbSNP
rs1040677935 235 dbSNP
rs71354862 235 dbSNP
rs11870116 236 dbSNP
rs3826289 238 dbSNP
rs1265700329 242 dbSNP
rs1043410387 244 dbSNP
rs903563320 245 dbSNP
rs999271082 254 dbSNP
rs1436164121 257 dbSNP
rs762448114 261 dbSNP
rs550463254 262 dbSNP
rs960851364 263 dbSNP
rs1025985062 265 dbSNP
rs887477526 270 dbSNP
rs1157021113 277 dbSNP
rs767878768 277 dbSNP
rs1458934905 278 dbSNP
rs1006873955 280 dbSNP
rs1024283517 288 dbSNP
rs1033948843 301 dbSNP
rs974446613 305 dbSNP
rs959782964 309 dbSNP
rs374576190 317 dbSNP
rs1281047822 326 dbSNP
rs1348523081 327 dbSNP
rs1210031570 330 dbSNP
rs575990480 341 dbSNP
rs1317031262 345 dbSNP
rs1212874782 351 dbSNP
rs140615468 352 dbSNP
rs919941139 355 dbSNP
rs533050478 359 dbSNP
rs1306087504 360 dbSNP
rs552617546 360 dbSNP
rs766046481 365 dbSNP
rs1177474203 368 dbSNP
rs1252212737 369 dbSNP
rs1318835628 370 dbSNP
rs982816197 372 dbSNP
rs1024982542 375 dbSNP
rs1345883505 382 dbSNP
rs1175201869 383 dbSNP
rs1412694704 393 dbSNP
rs1396881819 395 dbSNP
rs912670932 400 dbSNP
rs944520103 406 dbSNP
rs1387903133 408 dbSNP
rs566112037 410 dbSNP
rs1236395358 413 dbSNP
rs1395096497 413 dbSNP
rs978185053 415 dbSNP
rs1209946753 419 dbSNP
rs534992046 421 dbSNP
rs1455981930 423 dbSNP
rs753418870 425 dbSNP
rs990441851 426 dbSNP
rs1341941409 432 dbSNP
rs1370389823 433 dbSNP
rs1044071641 437 dbSNP
rs1302331922 439 dbSNP
rs1445982918 444 dbSNP
rs754494712 445 dbSNP
rs943142828 450 dbSNP
rs1040238376 451 dbSNP
rs1386372427 457 dbSNP
rs901717861 459 dbSNP
rs1014140959 465 dbSNP
rs1412703131 467 dbSNP
rs1236455607 471 dbSNP
rs1179589790 478 dbSNP
rs929022857 485 dbSNP
rs1023813232 487 dbSNP
rs1047543093 491 dbSNP
rs1260185403 498 dbSNP
rs1212259575 499 dbSNP
rs1482900781 500 dbSNP
rs1161315407 507 dbSNP
rs905403136 508 dbSNP
rs1345895456 509 dbSNP
rs1308285170 511 dbSNP
rs1204948406 513 dbSNP
rs887413680 516 dbSNP
rs1252777228 517 dbSNP
rs1357482589 526 dbSNP
rs1487307159 534 dbSNP
rs778450285 535 dbSNP
rs1348321604 540 dbSNP
rs1253113071 542 dbSNP
rs1462351113 545 dbSNP
rs1162297786 546 dbSNP
rs1034308983 547 dbSNP
rs368910128 550 dbSNP
rs1417973086 555 dbSNP
rs879736929 558 dbSNP
rs752119661 564 dbSNP
rs1472550529 567 dbSNP
rs1187295349 570 dbSNP
rs1390100455 582 dbSNP
rs1429562130 587 dbSNP
rs79417186 588 dbSNP
rs117147963 592 dbSNP
rs1481185862 593 dbSNP
rs966873430 596 dbSNP
rs982765402 601 dbSNP
rs999552584 607 dbSNP
rs1032438352 608 dbSNP
rs958252833 609 dbSNP
rs1347147940 611 dbSNP
rs976283479 612 dbSNP
rs72887797 622 dbSNP
rs931839611 625 dbSNP
rs910424840 629 dbSNP
rs964622421 630 dbSNP
rs976021792 638 dbSNP
rs72029956 639 dbSNP
rs925212902 643 dbSNP
rs540911860 644 dbSNP
rs1215026966 645 dbSNP
rs1362532626 649 dbSNP
rs1297483231 652 dbSNP
rs928864897 653 dbSNP
rs1319655603 654 dbSNP
rs1232356567 655 dbSNP
rs1273414190 656 dbSNP
rs1469473872 658 dbSNP
rs1267123176 661 dbSNP
rs1191909614 664 dbSNP
rs1206288681 666 dbSNP
rs557247510 671 dbSNP
rs1486493058 673 dbSNP
rs1253929284 675 dbSNP
rs923088605 676 dbSNP
rs1188763283 677 dbSNP
rs1208155592 681 dbSNP
rs1348672495 689 dbSNP
rs896202425 694 dbSNP
rs1239698308 697 dbSNP
rs1311330018 701 dbSNP
rs777055952 704 dbSNP
rs1298921704 707 dbSNP
rs949166638 720 dbSNP
rs1423577066 724 dbSNP
rs575794010 733 dbSNP
rs929139003 744 dbSNP
rs1386518956 748 dbSNP
rs905346693 756 dbSNP
rs996101736 760 dbSNP
rs565998613 786 dbSNP
rs1377622002 798 dbSNP
rs1027171107 805 dbSNP
rs577484611 817 dbSNP
rs546124851 822 dbSNP
rs908965361 823 dbSNP
rs1395879951 831 dbSNP
rs941658685 836 dbSNP
rs1054791871 838 dbSNP
rs1445296438 841 dbSNP
rs1019578362 844 dbSNP
rs138166024 846 dbSNP
rs1236180310 847 dbSNP
rs1013772401 848 dbSNP
rs572551891 850 dbSNP
rs1046658538 855 dbSNP
rs1348360348 855 dbSNP
rs114568339 859 dbSNP
rs1028852965 872 dbSNP
rs953218765 873 dbSNP
rs1295667039 876 dbSNP
rs1376784540 876 dbSNP
rs1263378899 877 dbSNP
rs979692016 884 dbSNP
rs1293612391 892 dbSNP
rs1032894755 894 dbSNP
rs925161948 903 dbSNP
rs1436918444 904 dbSNP
rs902660974 906 dbSNP
rs1168124754 920 dbSNP
rs891437188 922 dbSNP
rs11657635 924 dbSNP
rs1218619199 926 dbSNP
rs1193967999 934 dbSNP
rs987766245 935 dbSNP
rs191110292 940 dbSNP
rs1212959511 941 dbSNP
rs765191260 950 dbSNP
rs949101679 951 dbSNP
rs1193926697 953 dbSNP
rs1341019374 954 dbSNP
rs1032800104 958 dbSNP
rs1251579176 963 dbSNP
rs1254753702 971 dbSNP
rs11656656 972 dbSNP
rs926384979 975 dbSNP
rs1356731557 987 dbSNP
rs1189096401 989 dbSNP
rs1259976210 993 dbSNP
rs544417628 994 dbSNP
rs1018258740 1001 dbSNP
rs1176791705 1004 dbSNP
rs965401565 1009 dbSNP
rs113458519 1010 dbSNP
rs1161289674 1019 dbSNP
rs1475491997 1020 dbSNP
rs62078661 1023 dbSNP
rs923204766 1026 dbSNP
rs11077880 1028 dbSNP
rs1357086898 1030 dbSNP
rs1208886626 1032 dbSNP
rs546209546 1039 dbSNP
rs1331940654 1045 dbSNP
rs1274502740 1046 dbSNP
rs75523858 1048 dbSNP
rs567684584 1051 dbSNP
rs1028382639 1053 dbSNP
rs1279531713 1053 dbSNP
rs969218945 1056 dbSNP
rs34664281 1059 dbSNP
rs1440445526 1060 dbSNP
rs1392635564 1061 dbSNP
rs1268651155 1066 dbSNP
rs1167175146 1068 dbSNP
rs916234793 1073 dbSNP
rs568565898 1074 dbSNP
rs1411103312 1078 dbSNP
rs555463718 1088 dbSNP
rs369752149 1104 dbSNP
rs1046605637 1105 dbSNP
rs181624428 1114 dbSNP
rs570986929 1115 dbSNP
rs1282947972 1117 dbSNP
rs1254551888 1118 dbSNP
rs935462296 1121 dbSNP
rs988048826 1131 dbSNP
rs202134911 1133 dbSNP
rs376724483 1133 dbSNP
rs185942582 1136 dbSNP
rs1233665838 1138 dbSNP
rs374970127 1140 dbSNP
rs35075307 1141 dbSNP
rs1018790774 1146 dbSNP
rs1328218905 1149 dbSNP
rs573160272 1150 dbSNP
rs1316055641 1153 dbSNP
rs773547757 1154 dbSNP
rs1453757467 1155 dbSNP
rs1408705053 1164 dbSNP
rs143376883 1167 dbSNP
rs1396471499 1168 dbSNP
rs1193905182 1172 dbSNP
rs1239864459 1176 dbSNP
rs1464001200 1176 dbSNP
rs372512476 1176 dbSNP
rs553933757 1176 dbSNP
rs1030219992 1177 dbSNP
rs950605790 1181 dbSNP
rs983814329 1183 dbSNP
rs1327849064 1184 dbSNP
rs1305837195 1185 dbSNP
rs1235307878 1186 dbSNP
rs1361609745 1188 dbSNP
rs139374747 1189 dbSNP
rs1433042603 1191 dbSNP
rs1443848508 1197 dbSNP
rs963570187 1198 dbSNP
rs901438860 1208 dbSNP
rs990553844 1209 dbSNP
rs1377064413 1210 dbSNP
rs1235718740 1214 dbSNP
rs113993912 1219 dbSNP
rs1417016770 1225 dbSNP
rs1340552200 1227 dbSNP
rs372606181 1228 dbSNP
rs1243157116 1231 dbSNP
rs1187891366 1234 dbSNP
rs1214358423 1236 dbSNP
rs1484858111 1238 dbSNP
rs1282908254 1241 dbSNP
rs1274086300 1253 dbSNP
rs1439802628 1255 dbSNP
rs1271200842 1256 dbSNP
rs949017088 1258 dbSNP
rs190353692 1260 dbSNP
rs536558598 1262 dbSNP
rs1468949068 1270 dbSNP
rs935593904 1273 dbSNP
rs1357359414 1290 dbSNP
rs1194250229 1292 dbSNP
rs1000278287 1303 dbSNP
rs1396807039 1311 dbSNP
rs1474347323 1312 dbSNP
rs560467227 1324 dbSNP
rs183267426 1325 dbSNP
rs956508512 1328 dbSNP
rs1474506482 1331 dbSNP
rs1411329296 1332 dbSNP
rs1009422584 1338 dbSNP
rs1480531031 1349 dbSNP
rs1323437980 1351 dbSNP
rs1206909454 1358 dbSNP
rs1393154989 1359 dbSNP
rs893946109 1360 dbSNP
rs1024865147 1361 dbSNP
rs1156768329 1363 dbSNP
rs8074685 1367 dbSNP
rs1363666824 1371 dbSNP
rs1390563421 1372 dbSNP
rs1227283247 1382 dbSNP
rs1039771582 1387 dbSNP
rs1299467666 1390 dbSNP
rs1370935971 1390 dbSNP
rs980425532 1392 dbSNP
rs1393350694 1393 dbSNP
rs1033762691 1394 dbSNP
rs901268020 1403 dbSNP
rs998307496 1416 dbSNP
rs1025649723 1417 dbSNP
rs887132511 1433 dbSNP
rs983825247 1436 dbSNP
rs1226871492 1453 dbSNP
rs908320487 1456 dbSNP
rs940167421 1462 dbSNP
rs776963887 1468 dbSNP
rs1458369543 1469 dbSNP
rs1252660144 1471 dbSNP
rs1004787672 1472 dbSNP
rs1211857252 1475 dbSNP
rs1469901478 1476 dbSNP
rs1273679152 1478 dbSNP
rs376037250 1479 dbSNP
rs749010978 1479 dbSNP
rs1016605657 1483 dbSNP
rs1215639940 1484 dbSNP
rs1308863408 1487 dbSNP
rs1224178930 1489 dbSNP
rs1491333991 1489 dbSNP
rs368403595 1489 dbSNP
rs3840052 1489 dbSNP
rs397778492 1489 dbSNP
rs1491237010 1490 dbSNP
rs1302254502 1492 dbSNP
rs1294568148 1497 dbSNP
rs63619162 1497 dbSNP
rs561976905 1501 dbSNP
rs1344004504 1508 dbSNP
rs748063664 1514 dbSNP
rs530914180 1538 dbSNP
rs143165035 1547 dbSNP
rs1242526801 1548 dbSNP
rs1023307001 1554 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HeLa
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in Chi_124B_2A8_130_50. RNA binding protein: AGO. Condition:HeLa cell miR-124 + B HITS-CLIP data was present in Chi_ControlA_2A8_130_50. RNA binding protein: AGO. Condition:HeLa cell Control A HITS-CLIP data was present in Chi_ControlB_2A8_130_50. RNA binding protein: AGO. Condition:HeLa cell Control B ...

- Chi SW; Zang JB; Mele A; Darnell RB, 2009, Nature.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' gacACCCCCGUCCUCCCCgc 5'
             || | |: || || |  
Target 5' --cUGAGAGUUGGUGGAG-- 3'
1 - 16
Article - Chi SW; Zang JB; Mele A; Darnell RB
- Nature, 2009
MicroRNAs (miRNAs) have critical roles in the regulation of gene expression; however, as miRNA activity requires base pairing with only 6-8 nucleotides of messenger RNA, predicting target mRNAs is a major challenge. Recently, high-throughput sequencing of RNAs isolated by crosslinking immunoprecipitation (HITS-CLIP) has identified functional protein-RNA interaction sites. Here we use HITS-CLIP to covalently crosslink native argonaute (Ago, also called Eif2c) protein-RNA complexes in mouse brain. This produced two simultaneous data sets-Ago-miRNA and Ago-mRNA binding sites-that were combined with bioinformatic analysis to identify interaction sites between miRNA and target mRNA. We validated genome-wide interaction maps for miR-124, and generated additional maps for the 20 most abundant miRNAs present in P13 mouse brain. Ago HITS-CLIP provides a general platform for exploring the specificity and range of miRNA action in vivo, and identifies precise sequences for targeting clinically relevant miRNA-mRNA interactions.
LinkOut: [PMID: 19536157]
CLIP-seq Support 1 for dataset Chi_124B_2A8_130_50
Method / RBP HITS-CLIP / AGO
Cell line / Condition HeLa / HeLa cell miR-124 + B
Location of target site ENST00000428789.2 | 3UTR | GGAGGGGCCAGGCUGG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 19536157 / Chi_HITSCLIP
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset Chi_ControlA_2A8_130_50
Method / RBP HITS-CLIP / AGO
Cell line / Condition HeLa / HeLa cell Control A
Location of target site ENST00000428789.2 | 3UTR | CUGAGAGUUGGUGGA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 19536157 / Chi_HITSCLIP
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset Chi_ControlB_2A8_130_50
Method / RBP HITS-CLIP / AGO
Cell line / Condition HeLa / HeLa cell Control B
Location of target site ENST00000428789.2 | 3UTR | CUGAGAGUUGGUGGAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 19536157 / Chi_HITSCLIP
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
63 hsa-miR-4749-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT082256 MED29 mediator complex subunit 29 2 4
MIRT112161 OTUD3 OTU deubiquitinase 3 2 2
MIRT150036 MIDN midnolin 2 2
MIRT246308 HIST2H2AA3 histone cluster 2 H2A family member a3 2 4
MIRT246320 HIST2H2AA4 histone cluster 2 H2A family member a4 2 4
MIRT248254 SP1 Sp1 transcription factor 2 2
MIRT257944 GIGYF1 GRB10 interacting GYF protein 1 2 2
MIRT466973 STARD7 StAR related lipid transfer domain containing 7 2 4
MIRT492322 SETD1B SET domain containing 1B 2 2
MIRT496204 EFCAB1 EF-hand calcium binding domain 1 2 2
MIRT497568 CCR6 C-C motif chemokine receptor 6 2 2
MIRT502990 CCDC71L coiled-coil domain containing 71 like 2 8
MIRT508300 SIX5 SIX homeobox 5 2 4
MIRT522472 ZAK mitogen-activated protein kinase kinase kinase 20 2 2
MIRT525825 VIMP selenoprotein S 2 4
MIRT528154 BCL2L1 BCL2 like 1 2 2
MIRT532606 SPTLC2 serine palmitoyltransferase long chain base subunit 2 2 2
MIRT551302 RPRM reprimo, TP53 dependent G2 arrest mediator homolog 2 2
MIRT568777 FAM53C family with sequence similarity 53 member C 2 6
MIRT570896 METTL21A methyltransferase like 21A 2 2
MIRT570963 TMBIM4 transmembrane BAX inhibitor motif containing 4 2 2
MIRT571167 ZNF85 zinc finger protein 85 2 2
MIRT576751 Tmem127 transmembrane protein 127 2 2
MIRT609854 DAZAP2 DAZ associated protein 2 2 2
MIRT627101 PDRG1 p53 and DNA damage regulated 1 2 2
MIRT637060 PRKAG1 protein kinase AMP-activated non-catalytic subunit gamma 1 2 2
MIRT639423 PKP1 plakophilin 1 2 2
MIRT643208 TYW3 tRNA-yW synthesizing protein 3 homolog 2 4
MIRT646251 PRSS38 protease, serine 38 2 2
MIRT647145 CYP27C1 cytochrome P450 family 27 subfamily C member 1 2 2
MIRT647429 ZKSCAN2 zinc finger with KRAB and SCAN domains 2 2 2
MIRT650666 GAPDHP44 glyceraldehyde 3 phosphate dehydrogenase pseudogene 44 2 2
MIRT651816 USP49 ubiquitin specific peptidase 49 2 2
MIRT657376 HMGA1 high mobility group AT-hook 1 2 2
MIRT658105 FOXK1 forkhead box K1 2 2
MIRT658161 FCHSD1 FCH and double SH3 domains 1 2 2
MIRT662754 LRRC3C leucine rich repeat containing 3C 2 2
MIRT667209 NIPAL1 NIPA like domain containing 1 2 2
MIRT687003 RPL35 ribosomal protein L35 2 2
MIRT707057 NACC2 NACC family member 2 2 2
MIRT709048 MRO maestro 2 2
MIRT709054 MGAT5B mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B 2 2
MIRT709446 VWA2 von Willebrand factor A domain containing 2 2 2
MIRT709847 SNX12 sorting nexin 12 2 2
MIRT710790 IFNLR1 interferon lambda receptor 1 2 2
MIRT711696 GMPR guanosine monophosphate reductase 2 2
MIRT712462 KCNC3 potassium voltage-gated channel subfamily C member 3 2 2
MIRT713884 MOB3A MOB kinase activator 3A 2 2
MIRT715329 NTN1 netrin 1 2 2
MIRT715927 CHD4 chromodomain helicase DNA binding protein 4 2 2
MIRT716533 ATF5 activating transcription factor 5 2 2
MIRT716937 CACNB1 calcium voltage-gated channel auxiliary subunit beta 1 2 2
MIRT717007 MFSD6 major facilitator superfamily domain containing 6 2 2
MIRT719139 DPYSL5 dihydropyrimidinase like 5 2 2
MIRT720853 MEF2D myocyte enhancer factor 2D 2 2
MIRT721484 LTB4R2 leukotriene B4 receptor 2 2 2
MIRT721517 DKK3 dickkopf WNT signaling pathway inhibitor 3 2 2
MIRT722895 LRRC20 leucine rich repeat containing 20 2 2
MIRT723066 GGA1 golgi associated, gamma adaptin ear containing, ARF binding protein 1 2 2
MIRT723086 INSIG1 insulin induced gene 1 2 2
MIRT723353 ASCL2 achaete-scute family bHLH transcription factor 2 2 2
MIRT723483 MINOS1 mitochondrial inner membrane organizing system 1 2 2
MIRT724576 NOTCH2 notch 2 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-4749 Fluorouracil 3385 NSC19893 approved resistant High Pancreatic Cancer cell line (PANC-1)
hsa-mir-4749 Gemcitabine 60750 NSC613327 approved resistant High Pancreatic Cancer cell line (PANC-1)
hsa-mir-4749 Paclitaxel 36314 NSC125973 approved resistant cell line (W1)
hsa-miR-4749-3p Cisplatin 5460033 NSC119875 approved resistant High Hypopharyngeal Cancer cell line (FaDu)
hsa-miR-4749-3p Tamoxifen+Fulvestrant sensitive cell line (LCC9)
hsa-miR-4749-3p Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)
hsa-miR-4749-3p Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (1500 ng/ml)
hsa-miR-4749-3p Cisplatin 5460033 NSC119875 approved resistant cell line (OVSAHO)
hsa-miR-4749-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (TOV-112D)

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