pre-miRNA Information
pre-miRNA hsa-mir-6751   
Genomic Coordinates chr11: 65129916 - 65129978
Description Homo sapiens miR-6751 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-6751-3p
Sequence 43| ACUGAGCCUCUCUCUCUCCAG |63
Evidence Experimental
Experiments Meta-analysis
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSM6795708 8 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs749989972 2 dbSNP
rs1266150108 3 dbSNP
rs1488089412 6 dbSNP
rs1259846893 8 dbSNP
rs3802937 10 dbSNP
rs371083440 12 dbSNP
rs1264909843 13 dbSNP
rs751042478 14 dbSNP
rs757551063 19 dbSNP
Putative Targets

Gene Information
Gene Symbol TBC1D10B   
Synonyms EPI64B, FP2461
Description TBC1 domain family member 10B
Transcript NM_015527   
Expression
Putative miRNA Targets on TBC1D10B
3'UTR of TBC1D10B
(miRNA target sites are highlighted)
>TBC1D10B|NM_015527|3'UTR
   1 CCTCTGCCCTGGGGCTGGACTGCATGGCCCCCCTCTTTCCCTCAGCCAAGAACAGGCCTGGCCCAAGGTGCCACCCCCTA
  81 GCACCTTGTCAGGCTGTCCCTTGCTGGGGAAAGTGGCTTGGTTCCCCATCTCCTCGCCAGCTGCTGATCCCTACACGGGC
 161 AGGACAGATGGGCAGCTGCAAATGAGTCTGGAGCCTCTCATCTCCCATGAGGCTCAGCTGGGGTCTCTGTCGCTCCTGCC
 241 CCAGTTCCCTCTGGGTCCCCTCCTAGGTGCTGTCCTGAATGGCCCGTTGTCATCCCAGGGGTGACTCCTGGTGATGGGAG
 321 TCAGCAGTTTCAGATTCTTACACTCCATAGCTCCCCTTACCATGAGGTGGAGCTGGCTTCCTTTTCCCTGTCTTCAGCCC
 401 TCCCTGTCTCCCCCACTTCCTGGCCAGGGCTCTCATTCTGGACCTGTGTTGTAATTGTGTACAGAGGATGGCGTTGGCCT
 481 GGGGTGGGGGTGCTCGCTTTGTCTTCTGTCCTTTGGTTCTCCTTCCATAATGCTCCTGTACCCAGTTTATTTAAGGGGAC
 561 ATGCACTGGAATAGGAAATGTCCCCCATCTCCCTTCCTGCACCCTGCTGTGCTCCCTCCAAACCCACCTTGCTCTGTGTT
 641 CTCAGGCCCCCCTGCTTTTGTCTCACCAGGACCCATACCTTTCACCTTGTTCCCTTCCACCCCTCCAGTTAGTCCCTATC
 721 TGGGTAAGGGTCTTCCCTTGAGCTCCAGGGGGTGGAACCCAATGTTTACATTCTCTTCTGTCTCTGCCCCCACCCCATGC
 801 AGCGCTTTGAGGAATTGGAAAAGAACCTGCTGTTGTACCTGGGAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
 881 A
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' gaccucucucuCUCCGAGUCa 5'
                     ||||||||| 
Target 5' tcatctcccatGAGGCTCAGc 3'
198 - 218 150.00 -15.10
2
miRNA  3' gaccUCUCUCUCUCCGAGUCa 5'
              :|:|| || ||||::| 
Target 5' tgctGGGGAAAGTGGCTTGGt 3'
102 - 122 129.00 -21.30
3
miRNA  3' gacCUCUCUCUC-UCCGAGUCa 5'
             |:|||  || || :|||| 
Target 5' gatGGGAGTCAGCAGTTTCAGa 3'
313 - 334 114.00 -14.30
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN24436344 1 COSMIC
COSN28865361 28 COSMIC
COSN24313946 39 COSMIC
COSN30528123 39 COSMIC
COSN31490931 43 COSMIC
COSN30111538 136 COSMIC
COSN31557245 157 COSMIC
COSN26678146 160 COSMIC
COSN31588464 325 COSMIC
COSN7304143 339 COSMIC
COSN31591090 493 COSMIC
COSN8497547 508 COSMIC
COSN30166612 647 COSMIC
COSN31515051 823 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1249180355 1 dbSNP
rs769610122 3 dbSNP
rs1481386424 9 dbSNP
rs35844243 10 dbSNP
rs1234983266 14 dbSNP
rs897333527 17 dbSNP
rs1323457472 18 dbSNP
rs183939224 21 dbSNP
rs900278129 22 dbSNP
rs1315243291 24 dbSNP
rs1182282212 26 dbSNP
rs1306335462 28 dbSNP
rs1224566441 31 dbSNP
rs1218470388 32 dbSNP
rs1375722568 33 dbSNP
rs1483160653 34 dbSNP
rs766447131 34 dbSNP
rs1300867082 35 dbSNP
rs763111997 37 dbSNP
rs1406520838 41 dbSNP
rs34209355 42 dbSNP
rs1338679849 43 dbSNP
rs1455552177 46 dbSNP
rs1472550119 58 dbSNP
rs551332251 63 dbSNP
rs777035389 70 dbSNP
rs546873167 75 dbSNP
rs1417371902 77 dbSNP
rs1048147357 99 dbSNP
rs929136900 105 dbSNP
rs1382427436 106 dbSNP
rs1044117370 109 dbSNP
rs1318964968 110 dbSNP
rs920453615 112 dbSNP
rs973274909 118 dbSNP
rs1338100638 120 dbSNP
rs992788364 121 dbSNP
rs142025531 127 dbSNP
rs959421729 131 dbSNP
rs761165757 133 dbSNP
rs866314820 135 dbSNP
rs191642781 136 dbSNP
rs547564839 137 dbSNP
rs970754312 140 dbSNP
rs187107573 155 dbSNP
rs985521231 156 dbSNP
rs1487372426 157 dbSNP
rs1362265075 166 dbSNP
rs1010260840 169 dbSNP
rs1158897267 181 dbSNP
rs1424434004 183 dbSNP
rs1468120299 196 dbSNP
rs958326406 202 dbSNP
rs1338165724 203 dbSNP
rs1406088144 205 dbSNP
rs1445593505 205 dbSNP
rs866882215 207 dbSNP
rs1294084250 213 dbSNP
rs1030046771 218 dbSNP
rs1280456658 220 dbSNP
rs996972651 223 dbSNP
rs998465787 224 dbSNP
rs993885975 231 dbSNP
rs1265094586 233 dbSNP
rs74015006 235 dbSNP
rs1195297477 238 dbSNP
rs1229426580 243 dbSNP
rs543735573 249 dbSNP
rs1005708650 251 dbSNP
rs112155777 252 dbSNP
rs564094794 256 dbSNP
rs1479416932 261 dbSNP
rs1277530631 263 dbSNP
rs1398101571 267 dbSNP
rs1044148917 270 dbSNP
rs948461056 271 dbSNP
rs890141692 272 dbSNP
rs1464688692 275 dbSNP
rs1303241928 276 dbSNP
rs545771039 278 dbSNP
rs1047627478 285 dbSNP
rs929186742 287 dbSNP
rs920543185 290 dbSNP
rs934599828 293 dbSNP
rs924491998 298 dbSNP
rs1037502442 301 dbSNP
rs1424749340 303 dbSNP
rs1403478484 307 dbSNP
rs1170362990 318 dbSNP
rs1157162084 324 dbSNP
rs138039987 341 dbSNP
rs182951776 341 dbSNP
rs1477141666 342 dbSNP
rs762799353 343 dbSNP
rs1271611331 345 dbSNP
rs1199681985 353 dbSNP
rs947224406 357 dbSNP
rs1196531946 360 dbSNP
rs926688649 363 dbSNP
rs910372195 365 dbSNP
rs1201281583 370 dbSNP
rs982213973 375 dbSNP
rs190425627 376 dbSNP
rs1269586293 383 dbSNP
rs1197756089 386 dbSNP
rs970738607 398 dbSNP
rs1374227711 399 dbSNP
rs1462192572 402 dbSNP
rs1162343726 403 dbSNP
rs775232055 414 dbSNP
rs913861168 416 dbSNP
rs1305316080 421 dbSNP
rs1318819817 425 dbSNP
rs954085889 427 dbSNP
rs1328212452 431 dbSNP
rs1257210953 432 dbSNP
rs1216504610 434 dbSNP
rs1314705176 435 dbSNP
rs374753805 444 dbSNP
rs1357528520 448 dbSNP
rs1325592444 451 dbSNP
rs772071014 453 dbSNP
rs1292182780 455 dbSNP
rs769768949 458 dbSNP
rs1485507556 460 dbSNP
rs988175683 465 dbSNP
rs1263748534 466 dbSNP
rs747944854 471 dbSNP
rs961393134 472 dbSNP
rs1328825265 473 dbSNP
rs796966004 474 dbSNP
rs541536129 477 dbSNP
rs1446031284 481 dbSNP
rs1005741167 483 dbSNP
rs1453686931 484 dbSNP
rs370135448 486 dbSNP
rs996961432 495 dbSNP
rs574208706 496 dbSNP
rs185658377 503 dbSNP
rs1432172354 529 dbSNP
rs1380898515 533 dbSNP
rs537368559 535 dbSNP
rs1315488174 538 dbSNP
rs745826375 539 dbSNP
rs890225748 549 dbSNP
rs779149121 554 dbSNP
rs576302438 557 dbSNP
rs1173661388 558 dbSNP
rs1047826634 559 dbSNP
rs1376024203 560 dbSNP
rs1262463662 561 dbSNP
rs1486140737 562 dbSNP
rs1202509584 563 dbSNP
rs1012639557 565 dbSNP
rs993182258 566 dbSNP
rs895518571 589 dbSNP
rs899046159 603 dbSNP
rs1183756746 612 dbSNP
rs776392042 618 dbSNP
rs1418924633 619 dbSNP
rs11935 634 dbSNP
rs1157332115 636 dbSNP
rs1056809179 637 dbSNP
rs998964057 638 dbSNP
rs11552860 641 dbSNP
rs373094734 642 dbSNP
rs1046275423 647 dbSNP
rs947256983 652 dbSNP
rs1372835257 660 dbSNP
rs949474581 663 dbSNP
rs1308814988 670 dbSNP
rs1317480926 672 dbSNP
rs3766 674 dbSNP
rs988512254 675 dbSNP
rs565715288 679 dbSNP
rs547917132 685 dbSNP
rs922712159 703 dbSNP
rs1479427910 718 dbSNP
rs147905713 720 dbSNP
rs1342736033 722 dbSNP
rs564118514 730 dbSNP
rs976860457 743 dbSNP
rs770077017 748 dbSNP
rs1473214372 753 dbSNP
rs13335932 755 dbSNP
rs908526635 763 dbSNP
rs984350748 764 dbSNP
rs964167819 765 dbSNP
rs1354186489 766 dbSNP
rs1460620937 768 dbSNP
rs1127447 773 dbSNP
rs1019712768 774 dbSNP
rs1375702308 775 dbSNP
rs1373714175 780 dbSNP
rs986949979 782 dbSNP
rs1306627332 783 dbSNP
rs1023093794 786 dbSNP
rs1347286435 792 dbSNP
rs1013006589 803 dbSNP
rs1271633766 804 dbSNP
rs1305410802 808 dbSNP
rs1206116734 809 dbSNP
rs758665212 815 dbSNP
rs1483625005 817 dbSNP
rs1035890127 821 dbSNP
rs1267442833 826 dbSNP
rs796403587 827 dbSNP
rs1418807711 830 dbSNP
rs1335501411 839 dbSNP
rs113675707 843 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HeLa
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in Chi_ControlB_2A8_130_50. RNA binding protein: AGO. Condition:HeLa cell Control B ...

- Chi SW; Zang JB; Mele A; Darnell RB, 2009, Nature.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' gaccucucucuCUCCGAGUCa 5'
                     ||||||||| 
Target 5' ---------auGAGGCUCAGc 3'
1 - 12
Article - Chi SW; Zang JB; Mele A; Darnell RB
- Nature, 2009
MicroRNAs (miRNAs) have critical roles in the regulation of gene expression; however, as miRNA activity requires base pairing with only 6-8 nucleotides of messenger RNA, predicting target mRNAs is a major challenge. Recently, high-throughput sequencing of RNAs isolated by crosslinking immunoprecipitation (HITS-CLIP) has identified functional protein-RNA interaction sites. Here we use HITS-CLIP to covalently crosslink native argonaute (Ago, also called Eif2c) protein-RNA complexes in mouse brain. This produced two simultaneous data sets-Ago-miRNA and Ago-mRNA binding sites-that were combined with bioinformatic analysis to identify interaction sites between miRNA and target mRNA. We validated genome-wide interaction maps for miR-124, and generated additional maps for the 20 most abundant miRNAs present in P13 mouse brain. Ago HITS-CLIP provides a general platform for exploring the specificity and range of miRNA action in vivo, and identifies precise sequences for targeting clinically relevant miRNA-mRNA interactions.
LinkOut: [PMID: 19536157]
CLIP-seq Support 1 for dataset Chi_ControlB_2A8_130_50
Method / RBP HITS-CLIP / AGO
Cell line / Condition HeLa / HeLa cell Control B
Location of target site ENST00000409939.3 | 3UTR | AUGAGGCUCAGCUGGGGUCUCU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 19536157 / Chi_HITSCLIP
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
77 hsa-miR-6751-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT130738 GATAD2B GATA zinc finger domain containing 2B 2 4
MIRT134924 CCND2 cyclin D2 2 2
MIRT273034 ZBTB18 zinc finger and BTB domain containing 18 2 2
MIRT276645 KPNA3 karyopherin subunit alpha 3 2 6
MIRT446531 OAS2 2'-5'-oligoadenylate synthetase 2 2 2
MIRT456268 TDRKH tudor and KH domain containing 2 12
MIRT494454 BTG2 BTG anti-proliferation factor 2 2 2
MIRT494965 USP46 ubiquitin specific peptidase 46 2 2
MIRT496689 KREMEN1 kringle containing transmembrane protein 1 2 2
MIRT496697 RGS11 regulator of G protein signaling 11 2 2
MIRT504376 IRF4 interferon regulatory factor 4 2 6
MIRT510980 PFN2 profilin 2 2 6
MIRT512548 MFN2 mitofusin 2 2 6
MIRT513639 TP53INP2 tumor protein p53 inducible nuclear protein 2 2 2
MIRT514016 CAMSAP1 calmodulin regulated spectrin associated protein 1 2 4
MIRT514074 MTRNR2L6 MT-RNR2-like 6 2 2
MIRT515300 C15orf38-AP3S2 C15orf38-AP3S2 readthrough 2 4
MIRT517285 AP3S2 adaptor related protein complex 3 sigma 2 subunit 2 4
MIRT519075 KCNK6 potassium two pore domain channel subfamily K member 6 2 2
MIRT520779 TCF23 transcription factor 23 2 2
MIRT522485 MFSD9 major facilitator superfamily domain containing 9 2 2
MIRT528856 PKP1 plakophilin 1 2 2
MIRT529081 PATE2 prostate and testis expressed 2 2 2
MIRT531209 PLA2G4D phospholipase A2 group IVD 2 2
MIRT533988 TAB3 TGF-beta activated kinase 1 and MAP3K7 binding protein 3 2 2
MIRT537024 GRIN2B glutamate ionotropic receptor NMDA type subunit 2B 2 2
MIRT537498 FAM168B family with sequence similarity 168 member B 2 2
MIRT553125 UBE2Z ubiquitin conjugating enzyme E2 Z 2 2
MIRT555591 PIP5K1C phosphatidylinositol-4-phosphate 5-kinase type 1 gamma 2 2
MIRT556370 LUZP1 leucine zipper protein 1 2 2
MIRT569745 C2orf71 chromosome 2 open reading frame 71 2 2
MIRT570149 DNAJC10 DnaJ heat shock protein family (Hsp40) member C10 2 2
MIRT571243 FADS6 fatty acid desaturase 6 2 2
MIRT573065 TRIB1 tribbles pseudokinase 1 2 2
MIRT575533 Map4 microtubule-associated protein 4 2 2
MIRT575777 Tnfrsf10b tumor necrosis factor receptor superfamily, member 10b 2 2
MIRT616558 ZNF512B zinc finger protein 512B 2 2
MIRT624851 ABI2 abl interactor 2 2 2
MIRT630078 GRWD1 glutamate rich WD repeat containing 1 2 2
MIRT631479 KLHL21 kelch like family member 21 2 2
MIRT632173 CCL22 C-C motif chemokine ligand 22 2 2
MIRT638397 QSOX2 quiescin sulfhydryl oxidase 2 2 4
MIRT641192 ISG20L2 interferon stimulated exonuclease gene 20 like 2 2 2
MIRT642562 TEX9 testis expressed 9 2 2
MIRT642935 KRTAP5-9 keratin associated protein 5-9 2 2
MIRT649703 ZNF175 zinc finger protein 175 2 2
MIRT650437 CPXM2 carboxypeptidase X, M14 family member 2 2 2
MIRT652113 TRUB2 TruB pseudouridine synthase family member 2 2 2
MIRT652273 TOMM20 translocase of outer mitochondrial membrane 20 2 2
MIRT655215 PFKM phosphofructokinase, muscle 2 2
MIRT682778 ZNF852 zinc finger protein 852 2 2
MIRT683001 MUC20 mucin 20, cell surface associated 2 2
MIRT684320 GTF3C4 general transcription factor IIIC subunit 4 2 2
MIRT689435 CYB561 cytochrome b561 2 2
MIRT693847 ZNF107 zinc finger protein 107 2 2
MIRT696715 TAX1BP3 Tax1 binding protein 3 2 2
MIRT698597 TEX261 testis expressed 261 2 2
MIRT699973 RREB1 ras responsive element binding protein 1 2 2
MIRT703310 GFPT1 glutamine--fructose-6-phosphate transaminase 1 2 2
MIRT706796 RAI1 retinoic acid induced 1 2 2
MIRT709004 CD109 CD109 molecule 2 2
MIRT709181 TBC1D10B TBC1 domain family member 10B 2 2
MIRT709835 PAQR7 progestin and adipoQ receptor family member 7 2 2
MIRT711627 CORO1C coronin 1C 2 2
MIRT712634 RNF103-CHMP3 RNF103-CHMP3 readthrough 2 2
MIRT713694 CYB5R4 cytochrome b5 reductase 4 2 2
MIRT713752 SLC9A8 solute carrier family 9 member A8 2 2
MIRT714908 CHMP3 charged multivesicular body protein 3 2 2
MIRT716371 CBLL1 Cbl proto-oncogene like 1 2 2
MIRT718303 XPOT exportin for tRNA 2 2
MIRT718713 ANKRD18A ankyrin repeat domain 18A 2 2
MIRT718740 ATP9A ATPase phospholipid transporting 9A (putative) 2 2
MIRT719441 NPTX2 neuronal pentraxin 2 2 2
MIRT720896 OTUD4 OTU deubiquitinase 4 2 2
MIRT722448 RXFP4 relaxin/insulin like family peptide receptor 4 2 2
MIRT723882 VKORC1 vitamin K epoxide reductase complex subunit 1 2 2
MIRT724586 SYNJ2BP synaptojanin 2 binding protein 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-6751 Cisplatin 5460033 NSC119875 approved sensitive Low Ovarian Cancer cell line (A2780)
hsa-mir-6751 Triptolide 107985 NSC163062 sensitive Low Ovarian Cancer cell line (A2780)

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